RPS7P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.97320355
2translational termination (GO:0006415)9.47014412
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.03607797
4translational elongation (GO:0006414)7.98319242
5cotranslational protein targeting to membrane (GO:0006613)7.88967274
6protein targeting to ER (GO:0045047)7.82518489
7ribosomal small subunit assembly (GO:0000028)7.63407143
8establishment of protein localization to endoplasmic reticulum (GO:0072599)7.52296587
9chaperone-mediated protein transport (GO:0072321)7.51679539
10cellular protein complex disassembly (GO:0043624)7.31012509
11protein localization to endoplasmic reticulum (GO:0070972)7.30034587
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.13944595
13viral life cycle (GO:0019058)7.11000827
14translational initiation (GO:0006413)6.49180118
15protein complex disassembly (GO:0043241)6.17486572
16macromolecular complex disassembly (GO:0032984)5.80170225
17translation (GO:0006412)5.49184689
18protein targeting to membrane (GO:0006612)5.30588671
19ribonucleoprotein complex biogenesis (GO:0022613)5.29931981
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23335469
21ATP synthesis coupled proton transport (GO:0015986)5.23335469
22ribosomal large subunit biogenesis (GO:0042273)5.21852756
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10011179
24establishment of protein localization to mitochondrial membrane (GO:0090151)5.05391086
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.95488659
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.90257120
27protein neddylation (GO:0045116)4.79058098
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.78496339
29NADH dehydrogenase complex assembly (GO:0010257)4.78496339
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.78496339
31cellular component biogenesis (GO:0044085)4.70502205
32rRNA processing (GO:0006364)4.61280373
33mRNA catabolic process (GO:0006402)4.61196374
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.58041468
35respiratory electron transport chain (GO:0022904)4.53896047
36protein targeting to mitochondrion (GO:0006626)4.50353115
37electron transport chain (GO:0022900)4.44400081
38rRNA metabolic process (GO:0016072)4.42881819
39pseudouridine synthesis (GO:0001522)4.28127058
40protein complex biogenesis (GO:0070271)4.19019506
41RNA catabolic process (GO:0006401)4.17618172
42embryonic skeletal joint morphogenesis (GO:0060272)4.14486573
43establishment of protein localization to mitochondrion (GO:0072655)4.04556119
44mitochondrial respiratory chain complex assembly (GO:0033108)4.00261365
45pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.96787505
46protein localization to mitochondrion (GO:0070585)3.92910531
47GTP biosynthetic process (GO:0006183)3.91032355
48regulation of mitochondrial translation (GO:0070129)3.86963218
49guanosine-containing compound biosynthetic process (GO:1901070)3.83793907
50termination of RNA polymerase III transcription (GO:0006386)3.76398170
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.76398170
52proteasome assembly (GO:0043248)3.76292331
53pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.75720370
54protein targeting (GO:0006605)3.75577582
55heterochromatin organization (GO:0070828)3.73081746
56substrate-independent telencephalic tangential migration (GO:0021826)3.69910234
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.69910234
58UTP biosynthetic process (GO:0006228)3.66009046
59peptidyl-histidine modification (GO:0018202)3.59463729
60establishment of protein localization to membrane (GO:0090150)3.59028448
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55982417
62establishment of protein localization to organelle (GO:0072594)3.47075774
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.45149076
64ncRNA 3-end processing (GO:0043628)3.43419502
65CTP biosynthetic process (GO:0006241)3.37468345
66CTP metabolic process (GO:0046036)3.37468345
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.37300571
68GMP metabolic process (GO:0046037)3.36524923
69DNA damage response, detection of DNA damage (GO:0042769)3.35854641
70deoxyribose phosphate biosynthetic process (GO:0046385)3.33981147
712-deoxyribonucleotide biosynthetic process (GO:0009265)3.33981147
72UTP metabolic process (GO:0046051)3.33052651
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30736052
74chromatin remodeling at centromere (GO:0031055)3.30037482
75protein deneddylation (GO:0000338)3.26544349
76ncRNA processing (GO:0034470)3.23273486
77pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.22371733
78ribosome biogenesis (GO:0042254)3.21225544
79ribonucleoside triphosphate biosynthetic process (GO:0009201)3.20988062
80ATP biosynthetic process (GO:0006754)3.20332639
81mitochondrial transport (GO:0006839)3.13422424
82spliceosomal snRNP assembly (GO:0000387)3.13171186
83outer ear morphogenesis (GO:0042473)3.12156313
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08802772
85pyrimidine nucleotide catabolic process (GO:0006244)3.04368755
86intracellular protein transmembrane import (GO:0044743)3.00869192
87pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.00384774
88cullin deneddylation (GO:0010388)2.99387717
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95801987
90negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.95249383
91nucleoside triphosphate biosynthetic process (GO:0009142)2.92465191
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.88496768
93RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.88484652
94kinetochore assembly (GO:0051382)2.88465981
95DNA deamination (GO:0045006)2.87420000
96pyrimidine nucleotide biosynthetic process (GO:0006221)2.86896116
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85832187
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85832187
99maturation of SSU-rRNA (GO:0030490)12.5333354
100ribosomal small subunit biogenesis (GO:0042274)11.4876286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.11112494
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.90112490
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92401761
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82310550
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71812342
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.55825055
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.35587781
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11970566
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98879202
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97875937
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92082663
12XRN2_22483619_ChIP-Seq_HELA_Human2.91634075
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86025928
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84838081
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.75481879
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69701430
17TTF2_22483619_ChIP-Seq_HELA_Human2.64868362
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38487569
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28940213
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24215682
21GABP_19822575_ChIP-Seq_HepG2_Human2.05217963
22POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.02979427
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02212219
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97931344
25VDR_23849224_ChIP-Seq_CD4+_Human1.95850019
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.93311483
27DCP1A_22483619_ChIP-Seq_HELA_Human1.92484829
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88877657
29FOXP3_21729870_ChIP-Seq_TREG_Human1.83683126
30KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.79916420
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77047249
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.74311300
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.72429981
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62836164
35EZH2_22144423_ChIP-Seq_EOC_Human1.61992646
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60317109
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.60137661
38ZNF263_19887448_ChIP-Seq_K562_Human1.58613033
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.56805406
40MYC_18940864_ChIP-ChIP_HL60_Human1.56408851
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54634611
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.54054407
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50622955
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50390550
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46311531
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41180006
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.38503230
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.37220979
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.36495962
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35688453
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31528091
52KDM5A_27292631_Chip-Seq_BREAST_Human1.31489153
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31298181
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30184696
55CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27868297
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27351067
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.25851910
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25378987
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24239824
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21585625
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.20841858
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20026925
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17743924
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.17586135
65ELK1_19687146_ChIP-ChIP_HELA_Human1.15050341
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12866860
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11714099
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11207420
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09811910
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08896570
71CTCF_20526341_ChIP-Seq_ESCs_Human1.06652723
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04632471
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03784164
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03482022
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.02212206
76VDR_21846776_ChIP-Seq_THP-1_Human1.01858913
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98149118
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97759556
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97735818
80OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94726533
81RNF2_27304074_Chip-Seq_NSC_Mouse0.94288327
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94196997
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92964858
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91575470
85BCL6_27268052_Chip-Seq_Bcells_Human0.90992733
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90814216
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90442484
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89746205
89TP53_22573176_ChIP-Seq_HFKS_Human0.88422532
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87892829
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87469241
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87469241
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87257323
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85714812
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85279686
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.85258830
97TAF2_19829295_ChIP-Seq_ESCs_Human0.84871251
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84813994
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84500270
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83499193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.27900746
2MP0006292_abnormal_olfactory_placode5.01229372
3MP0003123_paternal_imprinting4.62941366
4MP0002163_abnormal_gland_morphology3.16253170
5MP0000049_abnormal_middle_ear2.77779308
6MP0009053_abnormal_anal_canal2.73103224
7MP0003693_abnormal_embryo_hatching2.43732655
8MP0000678_abnormal_parathyroid_gland2.41680757
9MP0002160_abnormal_reproductive_system2.39885701
10MP0008789_abnormal_olfactory_epithelium2.14551553
11MP0002234_abnormal_pharynx_morphology2.03942845
12MP0003186_abnormal_redox_activity1.92678090
13MP0002837_dystrophic_cardiac_calcinosis1.90483842
14MP0004858_abnormal_nervous_system1.90278112
15MP0005646_abnormal_pituitary_gland1.90254836
16MP0009250_abnormal_appendicular_skeleto1.88648787
17MP0005499_abnormal_olfactory_system1.82568543
18MP0005394_taste/olfaction_phenotype1.82568543
19MP0004142_abnormal_muscle_tone1.80441137
20MP0003122_maternal_imprinting1.73034843
21MP0005379_endocrine/exocrine_gland_phen1.67639549
22MP0005389_reproductive_system_phenotype1.65925045
23MP0000537_abnormal_urethra_morphology1.57188376
24MP0004145_abnormal_muscle_electrophysio1.53479479
25MP0000631_abnormal_neuroendocrine_gland1.52503295
26MP0001293_anophthalmia1.52225746
27MP0002249_abnormal_larynx_morphology1.50554748
28MP0005187_abnormal_penis_morphology1.50160401
29MP0001529_abnormal_vocalization1.48594105
30MP0006036_abnormal_mitochondrial_physio1.45032289
31MP0003942_abnormal_urinary_system1.43329967
32MP0002638_abnormal_pupillary_reflex1.40283386
33MP0003121_genomic_imprinting1.39698363
34MP0001188_hyperpigmentation1.37567132
35MP0008932_abnormal_embryonic_tissue1.32492600
36MP0005084_abnormal_gallbladder_morpholo1.31013304
37MP0003938_abnormal_ear_development1.30251360
38MP0001919_abnormal_reproductive_system1.26410183
39MP0002938_white_spotting1.25366602
40MP0003646_muscle_fatigue1.25136139
41MP0003937_abnormal_limbs/digits/tail_de1.24505609
42MP0003941_abnormal_skin_development1.21943657
43MP0001270_distended_abdomen1.20651037
44MP0004885_abnormal_endolymph1.19757356
45MP0001905_abnormal_dopamine_level1.19598146
46MP0002233_abnormal_nose_morphology1.17563088
47MP0002132_abnormal_respiratory_system1.14414321
48MP0009046_muscle_twitch1.13562801
49MP0002102_abnormal_ear_morphology1.13335197
50MP0002177_abnormal_outer_ear1.07274886
51MP0010030_abnormal_orbit_morphology1.06639119
52MP0005083_abnormal_biliary_tract1.06451233
53MP0002736_abnormal_nociception_after1.02510877
54MP0003786_premature_aging1.00296607
55MP0006276_abnormal_autonomic_nervous0.99725598
56MP0003567_abnormal_fetal_cardiomyocyte0.95660615
57MP0009384_cardiac_valve_regurgitation0.95641751
58MP0000778_abnormal_nervous_system0.95024170
59MP0001485_abnormal_pinna_reflex0.92321459
60MP0003787_abnormal_imprinting0.91956015
61MP0003119_abnormal_digestive_system0.90759177
62MP0003315_abnormal_perineum_morphology0.89654058
63MP0002277_abnormal_respiratory_mucosa0.88014935
64MP0001286_abnormal_eye_development0.87911128
65MP0002116_abnormal_craniofacial_bone0.83462509
66MP0000681_abnormal_thyroid_gland0.82846920
67MP0009745_abnormal_behavioral_response0.82835332
68MP0004957_abnormal_blastocyst_morpholog0.82309411
69MP0006072_abnormal_retinal_apoptosis0.81752457
70MP0001968_abnormal_touch/_nociception0.80585348
71MP0000026_abnormal_inner_ear0.79823595
72MP0005623_abnormal_meninges_morphology0.79402143
73MP0008058_abnormal_DNA_repair0.78593498
74MP0003755_abnormal_palate_morphology0.78566525
75MP0002932_abnormal_joint_morphology0.78565766
76MP0002876_abnormal_thyroid_physiology0.78263014
77MP0002210_abnormal_sex_determination0.77685327
78MP0003111_abnormal_nucleus_morphology0.76723466
79MP0003880_abnormal_central_pattern0.75795335
80MP0002184_abnormal_innervation0.75040422
81MP0001502_abnormal_circadian_rhythm0.74762099
82MP0000534_abnormal_ureter_morphology0.73633941
83MP0003283_abnormal_digestive_organ0.73453601
84MP0002092_abnormal_eye_morphology0.73080960
85MP0002095_abnormal_skin_pigmentation0.73068083
86MP0003137_abnormal_impulse_conducting0.72908073
87MP0008775_abnormal_heart_ventricle0.71090214
88MP0005195_abnormal_posterior_eye0.70365272
89MP0001963_abnormal_hearing_physiology0.69942944
90MP0005551_abnormal_eye_electrophysiolog0.67990719
91MP0008875_abnormal_xenobiotic_pharmacok0.67092809
92MP0000343_altered_response_to0.66668455
93MP0001986_abnormal_taste_sensitivity0.66238016
94MP0002109_abnormal_limb_morphology0.66233190
95MP0000955_abnormal_spinal_cord0.66178099
96MP0002752_abnormal_somatic_nervous0.65490361
97MP0003011_delayed_dark_adaptation0.65328309
98MP0006035_abnormal_mitochondrial_morpho0.64961308
99MP0004130_abnormal_muscle_cell0.63133425
100MP0005391_vision/eye_phenotype0.61093876

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.77951416
2Acute necrotizing encephalopathy (HP:0006965)5.25002138
3Macrocytic anemia (HP:0001972)5.11144332
4Abnormality of cells of the erythroid lineage (HP:0012130)4.78928231
5Abnormal mitochondria in muscle tissue (HP:0008316)4.76204206
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.63404185
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.63404185
8Abnormal number of erythroid precursors (HP:0012131)4.33931657
9Acute encephalopathy (HP:0006846)4.29727710
103-Methylglutaconic aciduria (HP:0003535)4.23031114
11Progressive macrocephaly (HP:0004481)4.20692719
12Mitochondrial inheritance (HP:0001427)4.10294758
13Microretrognathia (HP:0000308)3.96393742
14Increased CSF lactate (HP:0002490)3.91511551
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.63562914
16Pallor (HP:0000980)3.54132675
17Cerebral edema (HP:0002181)3.17563301
18Cleft eyelid (HP:0000625)3.17437654
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.12203638
20Abnormality of alanine metabolism (HP:0010916)3.12203638
21Hyperalaninemia (HP:0003348)3.12203638
22Hepatocellular necrosis (HP:0001404)3.04104955
23Hepatic necrosis (HP:0002605)3.00553545
24Abnormality of the phalanges of the hallux (HP:0010057)2.99788639
25Increased serum lactate (HP:0002151)2.79374162
26Increased hepatocellular lipid droplets (HP:0006565)2.67977247
27Molar tooth sign on MRI (HP:0002419)2.66461629
28Abnormality of midbrain morphology (HP:0002418)2.66461629
29Testicular atrophy (HP:0000029)2.62391433
30Double outlet right ventricle (HP:0001719)2.61547784
31Congenital malformation of the right heart (HP:0011723)2.61547784
32Progressive microcephaly (HP:0000253)2.58325878
33Respiratory failure (HP:0002878)2.57674810
34Broad distal phalanx of finger (HP:0009836)2.57525359
35Abnormal rod and cone electroretinograms (HP:0008323)2.56996845
36Increased intramyocellular lipid droplets (HP:0012240)2.54344137
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52935008
38Abnormality of the middle phalanges of the toes (HP:0010183)2.51085052
39Hypoplasia of the radius (HP:0002984)2.49488287
40Lactic acidosis (HP:0003128)2.49452215
41Renal Fanconi syndrome (HP:0001994)2.44197861
42Triphalangeal thumb (HP:0001199)2.43328393
43Abnormal number of incisors (HP:0011064)2.42840546
44Absent thumb (HP:0009777)2.40100013
45Down-sloping shoulders (HP:0200021)2.38779767
46Short middle phalanx of the 5th finger (HP:0004220)2.35429268
47Occipital encephalocele (HP:0002085)2.31496788
48Lipid accumulation in hepatocytes (HP:0006561)2.28513928
49Degeneration of anterior horn cells (HP:0002398)2.28267772
50Abnormality of the anterior horn cell (HP:0006802)2.28267772
51Respiratory difficulties (HP:0002880)2.27088145
52Abnormality of the 4th metacarpal (HP:0010012)2.26712318
53Type II lissencephaly (HP:0007260)2.26082001
54Ectopic kidney (HP:0000086)2.25128412
55Renal dysplasia (HP:0000110)2.23484891
56Congenital stationary night blindness (HP:0007642)2.21925188
57Esophageal atresia (HP:0002032)2.21602484
58Leukodystrophy (HP:0002415)2.20601124
59Rectal prolapse (HP:0002035)2.18895197
60Partial duplication of thumb phalanx (HP:0009944)2.17354754
61Myokymia (HP:0002411)2.15717098
62Patent foramen ovale (HP:0001655)2.14729357
63Partial duplication of the phalanx of hand (HP:0009999)2.13434020
64Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.12637036
65Exercise intolerance (HP:0003546)2.08898365
66Abnormal ventriculo-arterial connection (HP:0011563)2.08855883
67Transposition of the great arteries (HP:0001669)2.08855883
68Abnormal connection of the cardiac segments (HP:0011545)2.08855883
69Depressed nasal ridge (HP:0000457)2.07297303
70Absent/shortened dynein arms (HP:0200106)2.07125889
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.07125889
72Hyperglycinemia (HP:0002154)2.05663586
73Abnormality of the phalanges of the 5th finger (HP:0004213)2.05556882
74Anencephaly (HP:0002323)2.05081802
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05059041
76Increased muscle lipid content (HP:0009058)2.04860475
77Abnormality of urine glucose concentration (HP:0011016)2.01874116
78Glycosuria (HP:0003076)2.01874116
79Pancreatic fibrosis (HP:0100732)1.96722039
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95338494
81Symphalangism affecting the phalanges of the hand (HP:0009773)1.94249258
82Porencephaly (HP:0002132)1.93654918
83Birth length less than 3rd percentile (HP:0003561)1.93527568
84Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93283050
85Forearm undergrowth (HP:0009821)1.91958221
86Aplasia/hypoplasia of the uterus (HP:0008684)1.91244368
87Pancreatic cysts (HP:0001737)1.90173321
88Optic disc pallor (HP:0000543)1.86938260
89Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86635703
90Abnormality of magnesium homeostasis (HP:0004921)1.86349425
91Gout (HP:0001997)1.85022413
92Exertional dyspnea (HP:0002875)1.84116138
93Abnormal hemoglobin (HP:0011902)1.80013534
94Hypoplasia of the uterus (HP:0000013)1.79138117
95Short thumb (HP:0009778)1.77515832
96Facial hemangioma (HP:0000329)1.75323654
97Absent phalangeal crease (HP:0006109)1.75097814
98X-linked dominant inheritance (HP:0001423)1.74927831
99Lethargy (HP:0001254)1.74209000
100Hyperphosphaturia (HP:0003109)1.73436163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.57309065
2PDK24.79348160
3BUB13.48678575
4ARAF2.94078724
5LRRK22.87651153
6STK162.86716624
7TLK12.65255210
8IRAK32.54380539
9WNK42.16960095
10PIM22.13454346
11ICK2.11722312
12EPHB21.96802904
13CDC71.81382586
14BCKDK1.69918539
15NEK11.69792841
16CAMKK21.67662439
17ADRBK21.58732217
18MAP3K111.57580829
19GRK11.53584436
20SRPK11.50953862
21DYRK21.50391126
22CDK191.49824045
23TESK21.48028934
24EIF2AK11.42332906
25CCNB11.40999960
26ABL21.29473437
27PASK1.26744874
28LIMK11.22864221
29PLK41.18464424
30AURKA1.18255060
31PIK3CA1.12461358
32RPS6KA41.10369397
33RPS6KA51.02778980
34PLK10.99709924
35AURKB0.99411198
36CAMK10.96564803
37BRAF0.95505248
38MAP3K90.93733810
39EPHA40.90636367
40WNK30.89996025
41BMPR1B0.89325261
42CSNK2A20.82503214
43CSNK2A10.80629310
44IRAK40.80467675
45PRKCI0.78775261
46RPS6KA60.78756764
47MAP2K70.77448150
48PINK10.72821184
49CAMK1G0.72511621
50TIE10.72303657
51MAP4K20.69821172
52BRSK10.66592183
53CAMK1D0.66554568
54RPS6KC10.66216314
55RPS6KL10.66216314
56MOS0.64114134
57PIM10.63533686
58STK110.63395956
59MUSK0.61668219
60NUAK10.61419554
61CSNK1G30.60519842
62INSRR0.60227493
63IRAK20.58907809
64DMPK0.58362306
65PRKCG0.55256372
66CAMKK10.54351162
67TGFBR10.53528742
68ILK0.51817682
69OBSCN0.51492619
70PRKACA0.49185851
71TXK0.48279998
72IKBKB0.45543008
73ADRBK10.44019131
74CSNK1E0.42976249
75WEE10.41741400
76CHEK10.41333703
77WNK10.39687616
78VRK20.37706306
79CSNK1G20.36774871
80MKNK20.36544918
81RPS6KA10.36198635
82MINK10.34734744
83STK40.34694546
84TEC0.34515385
85PRKCQ0.34129452
86IKBKE0.32574672
87MAPK150.32077421
88NME10.31920678
89CDK40.31162708
90TRIM280.30684906
91CSNK1G10.29666410
92CHEK20.29236158
93DAPK30.29072044
94ZAK0.28020095
95PAK10.27852490
96TYRO30.27700120
97CDK20.27245080
98DYRK30.27090154
99CSNK1A10.25522748
100NTRK20.24672505

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.78604988
2Oxidative phosphorylation_Homo sapiens_hsa001904.66723159
3Parkinsons disease_Homo sapiens_hsa050123.93483930
4One carbon pool by folate_Homo sapiens_hsa006703.11790880
5RNA polymerase_Homo sapiens_hsa030203.01882036
6Huntingtons disease_Homo sapiens_hsa050162.97106051
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.95081602
8Alzheimers disease_Homo sapiens_hsa050102.74086233
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61214776
10Sulfur relay system_Homo sapiens_hsa041222.45785227
11Cardiac muscle contraction_Homo sapiens_hsa042602.10561279
12Pyrimidine metabolism_Homo sapiens_hsa002402.03624188
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96103305
14DNA replication_Homo sapiens_hsa030301.79212506
15Spliceosome_Homo sapiens_hsa030401.71058203
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70222954
17Vitamin B6 metabolism_Homo sapiens_hsa007501.65344369
18Protein export_Homo sapiens_hsa030601.58131048
19Proteasome_Homo sapiens_hsa030501.52820626
20Homologous recombination_Homo sapiens_hsa034401.39295624
21RNA degradation_Homo sapiens_hsa030181.33258852
22Fanconi anemia pathway_Homo sapiens_hsa034601.30311052
23RNA transport_Homo sapiens_hsa030131.19041374
24Purine metabolism_Homo sapiens_hsa002301.10473434
25Mismatch repair_Homo sapiens_hsa034301.09222352
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06175793
27Linoleic acid metabolism_Homo sapiens_hsa005911.04798511
28Nitrogen metabolism_Homo sapiens_hsa009101.01715745
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96923613
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96530937
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95262595
32Base excision repair_Homo sapiens_hsa034100.91916855
33Fat digestion and absorption_Homo sapiens_hsa049750.90939274
34Drug metabolism - other enzymes_Homo sapiens_hsa009830.86207464
35Nucleotide excision repair_Homo sapiens_hsa034200.84625616
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.83892986
37Metabolic pathways_Homo sapiens_hsa011000.81485931
38Pyruvate metabolism_Homo sapiens_hsa006200.77762235
39Sulfur metabolism_Homo sapiens_hsa009200.76428344
40Basal transcription factors_Homo sapiens_hsa030220.75971596
41Arginine and proline metabolism_Homo sapiens_hsa003300.74657714
42Collecting duct acid secretion_Homo sapiens_hsa049660.73715108
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65475938
44Folate biosynthesis_Homo sapiens_hsa007900.61381471
45Phenylalanine metabolism_Homo sapiens_hsa003600.60101443
46Tyrosine metabolism_Homo sapiens_hsa003500.57922429
47Arachidonic acid metabolism_Homo sapiens_hsa005900.57509002
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52656583
49Basal cell carcinoma_Homo sapiens_hsa052170.50758815
50Peroxisome_Homo sapiens_hsa041460.49060061
51Asthma_Homo sapiens_hsa053100.44475447
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43833493
53Phototransduction_Homo sapiens_hsa047440.43209985
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42367162
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42327671
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41988450
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.41455489
58Nicotine addiction_Homo sapiens_hsa050330.40354622
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39977631
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39316618
61p53 signaling pathway_Homo sapiens_hsa041150.39254525
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38696320
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37399121
64Retinol metabolism_Homo sapiens_hsa008300.36089488
65Steroid biosynthesis_Homo sapiens_hsa001000.35530383
66Glutathione metabolism_Homo sapiens_hsa004800.33530598
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32920011
68Chemical carcinogenesis_Homo sapiens_hsa052040.32691397
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31952322
70Cell cycle_Homo sapiens_hsa041100.30379108
71Hedgehog signaling pathway_Homo sapiens_hsa043400.30003119
72Fatty acid degradation_Homo sapiens_hsa000710.29611933
73Selenocompound metabolism_Homo sapiens_hsa004500.28587904
74Systemic lupus erythematosus_Homo sapiens_hsa053220.28407703
75Tryptophan metabolism_Homo sapiens_hsa003800.26919539
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.26653747
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24176580
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23943719
79Ether lipid metabolism_Homo sapiens_hsa005650.23515959
80Caffeine metabolism_Homo sapiens_hsa002320.22110554
81beta-Alanine metabolism_Homo sapiens_hsa004100.20847860
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19357277
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.18449108
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.16374499
85Pancreatic secretion_Homo sapiens_hsa049720.13972482
86Fatty acid elongation_Homo sapiens_hsa000620.13634437
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13235765
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12503521
89Olfactory transduction_Homo sapiens_hsa047400.12482566
90Arginine biosynthesis_Homo sapiens_hsa002200.12111657
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12027613
92Carbon metabolism_Homo sapiens_hsa012000.11135928
93Glycerolipid metabolism_Homo sapiens_hsa005610.10449495
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07376137
95Allograft rejection_Homo sapiens_hsa053300.06001023
96Regulation of autophagy_Homo sapiens_hsa041400.05955965
97Epstein-Barr virus infection_Homo sapiens_hsa051690.04356319
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04260766
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04032617
100Autoimmune thyroid disease_Homo sapiens_hsa053200.03685252

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