ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.93960457
2	ATP synthesis coupled proton transport (GO:0015986)	4.93960457
3	ribosomal small subunit assembly (GO:0000028)	4.77416960
4	chaperone-mediated protein transport (GO:0072321)	4.65110202
5	behavioral response to nicotine (GO:0035095)	4.47312584
6	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.44825291
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.44825291
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.38425274
9	cellular biogenic amine catabolic process (GO:0042402)	4.35501359
10	amine catabolic process (GO:0009310)	4.35501359
11	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.10370422
12	protein neddylation (GO:0045116)	4.05469935
13	DNA deamination (GO:0045006)	4.04432122
14	ribosomal small subunit biogenesis (GO:0042274)	3.85621687
15	peptidyl-histidine modification (GO:0018202)	3.81279362
16	GTP biosynthetic process (GO:0006183)	3.76829575
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.73751653
18	NADH dehydrogenase complex assembly (GO:0010257)	3.73751653
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.73751653
20	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.62026614
21	viral transcription (GO:0019083)	3.58929060
22	protein complex biogenesis (GO:0070271)	3.56971446
23	translational termination (GO:0006415)	3.56266420
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.54960751
25	pseudouridine synthesis (GO:0001522)	3.49330700
26	respiratory electron transport chain (GO:0022904)	3.47839835
27	electron transport chain (GO:0022900)	3.42848871
28	maturation of SSU-rRNA (GO:0030490)	3.42192924
29	thalamus development (GO:0021794)	3.38578502
30	respiratory chain complex IV assembly (GO:0008535)	3.28994612
31	tRNA processing (GO:0008033)	3.28759689
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.28183716
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.27511343
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.26157919
35	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.25619690
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25288868
37	cotranslational protein targeting to membrane (GO:0006613)	3.24210262
38	regulation of immunoglobulin secretion (GO:0051023)	3.21571348
39	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20480591
40	protein targeting to ER (GO:0045047)	3.19128625
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16321737
42	proteasome assembly (GO:0043248)	3.15807218
43	cytochrome complex assembly (GO:0017004)	3.13672241
44	UTP biosynthetic process (GO:0006228)	3.11006377
45	aldehyde catabolic process (GO:0046185)	3.09626633
46	ATP biosynthetic process (GO:0006754)	3.09012855
47	protein localization to endoplasmic reticulum (GO:0070972)	3.05745521
48	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.03050230
49	translational elongation (GO:0006414)	3.01864112
50	negative regulation of response to food (GO:0032096)	2.99373216
51	negative regulation of appetite (GO:0032099)	2.99373216
52	rRNA processing (GO:0006364)	2.96790803
53	indolalkylamine metabolic process (GO:0006586)	2.96113047
54	cellular component biogenesis (GO:0044085)	2.95508839
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.94585323
56	regulation of isotype switching to IgG isotypes (GO:0048302)	2.92398950
57	indole-containing compound catabolic process (GO:0042436)	2.92195637
58	indolalkylamine catabolic process (GO:0046218)	2.92195637
59	tryptophan catabolic process (GO:0006569)	2.92195637
60	translation (GO:0006412)	2.91625432
61	regulation of cellular respiration (GO:0043457)	2.91485020
62	rRNA metabolic process (GO:0016072)	2.90316216
63	ribosomal large subunit biogenesis (GO:0042273)	2.90116545
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86967200
65	kinetochore assembly (GO:0051382)	2.86217258
66	ncRNA 3-end processing (GO:0043628)	2.84646245
67	response to xenobiotic stimulus (GO:0009410)	2.83346565
68	cellular ketone body metabolic process (GO:0046950)	2.80650264
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.80524945
70	negative regulation of telomere maintenance (GO:0032205)	2.80310017
71	tRNA metabolic process (GO:0006399)	2.79635133
72	regulation of mitochondrial translation (GO:0070129)	2.77014999
73	UTP metabolic process (GO:0046051)	2.76979416
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75562547
75	termination of RNA polymerase III transcription (GO:0006386)	2.75562547
76	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.75427854
77	ribonucleoprotein complex biogenesis (GO:0022613)	2.73254895
78	proton transport (GO:0015992)	2.73230270
79	replication fork processing (GO:0031297)	2.73166386
80	negative regulation of B cell apoptotic process (GO:0002903)	2.72245995
81	neural tube formation (GO:0001841)	2.70116086
82	cellular protein complex disassembly (GO:0043624)	2.70020518
83	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.69582749
84	protein targeting to mitochondrion (GO:0006626)	2.68573908
85	hydrogen transport (GO:0006818)	2.68234907
86	intracellular protein transmembrane import (GO:0044743)	2.68060413
87	ncRNA processing (GO:0034470)	2.67810616
88	arginine catabolic process (GO:0006527)	2.66690334
89	hydrogen ion transmembrane transport (GO:1902600)	2.64365074
90	kynurenine metabolic process (GO:0070189)	2.63706826
91	viral life cycle (GO:0019058)	2.63660804
92	dopamine transport (GO:0015872)	2.63098403
93	mannosylation (GO:0097502)	2.61686249
94	CTP metabolic process (GO:0046036)	2.61516497
95	CTP biosynthetic process (GO:0006241)	2.61516497
96	cornea development in camera-type eye (GO:0061303)	2.60534338
97	transmission of nerve impulse (GO:0019226)	2.60144046
98	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.59424579
99	tryptophan metabolic process (GO:0006568)	2.57564309
100	maturation of 5.8S rRNA (GO:0000460)	2.56711962

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.13810838
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.09098812
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.85847892
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.54005820
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04809117
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81386094
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.72926240
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.71203483
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70394218
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.61273885
11	VDR_22108803_ChIP-Seq_LS180_Human	2.40394187
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35261384
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.16518783
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.13289099
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10621845
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01988560
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.99797672
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99376272
19	EWS_26573619_Chip-Seq_HEK293_Human	1.86681055
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84836648
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.81243189
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80477594
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80272462
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79987176
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.71199874
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71006033
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64895528
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63418102
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60547388
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60433885
31	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.59796775
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.55303218
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53681709
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49148728
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.44843850
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44287473
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.43324386
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.39684605
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.34440595
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34280725
41	P300_19829295_ChIP-Seq_ESCs_Human	1.31803498
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31465651
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30447680
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27928070
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27871252
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25995372
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25528607
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25528607
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22019780
50	NCOR_22424771_ChIP-Seq_293T_Human	1.20593312
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.18774571
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18356111
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17409304
54	ERA_21632823_ChIP-Seq_H3396_Human	1.12451249
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11290733
56	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10990303
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10564723
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10122231
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09900841
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09746278
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08459780
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.07863965
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07549619
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06401756
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06236411
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.04260370
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03463010
68	AR_20517297_ChIP-Seq_VCAP_Human	1.02982131
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02781980
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02773714
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02390044
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00509248
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00502324
74	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99756966
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99157478
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99047185
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98671722
78	FUS_26573619_Chip-Seq_HEK293_Human	0.97309780
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.96903093
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96903093
81	GBX2_23144817_ChIP-Seq_PC3_Human	0.96415229
82	STAT1_20625510_ChIP-Seq_HELA_Human	0.95724199
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94422124
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.93607209
85	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93274769
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93153173
87	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92919994
88	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.92388578
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92109415
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91235239
91	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90709826
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89555969
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89555969
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86829493
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86829493
96	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.85980285
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85959947
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.85957007
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85312563
100	DCP1A_22483619_ChIP-Seq_HELA_Human	0.84835434

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.89552056
2	MP0005360_urolithiasis	3.13264796
3	MP0003787_abnormal_imprinting	3.05369885
4	MP0006292_abnormal_olfactory_placode	2.99541875
5	MP0005645_abnormal_hypothalamus_physiol	2.94839464
6	MP0003718_maternal_effect	2.83037983
7	MP0002138_abnormal_hepatobiliary_system	2.78174461
8	MP0008875_abnormal_xenobiotic_pharmacok	2.73675376
9	MP0002163_abnormal_gland_morphology	2.68712503
10	MP0005085_abnormal_gallbladder_physiolo	2.67850271
11	MP0003252_abnormal_bile_duct	2.44471427
12	MP0005083_abnormal_biliary_tract	2.39565055
13	MP0001348_abnormal_lacrimal_gland	2.34315479
14	MP0005646_abnormal_pituitary_gland	2.15873961
15	MP0009379_abnormal_foot_pigmentation	2.04636638
16	MP0008872_abnormal_physiological_respon	1.93159191
17	MP0004142_abnormal_muscle_tone	1.88726109
18	MP0005084_abnormal_gallbladder_morpholo	1.79399527
19	MP0004145_abnormal_muscle_electrophysio	1.79018616
20	MP0008058_abnormal_DNA_repair	1.69833344
21	MP0002736_abnormal_nociception_after	1.64302248
22	MP0003186_abnormal_redox_activity	1.63073474
23	MP0005379_endocrine/exocrine_gland_phen	1.62299148
24	MP0006072_abnormal_retinal_apoptosis	1.56375821
25	MP0002638_abnormal_pupillary_reflex	1.54091336
26	MP0004742_abnormal_vestibular_system	1.52650130
27	MP0003646_muscle_fatigue	1.47438616
28	MP0003195_calcinosis	1.45785890
29	MP0002653_abnormal_ependyma_morphology	1.43948239
30	MP0008789_abnormal_olfactory_epithelium	1.42170981
31	MP0002938_white_spotting	1.37864549
32	MP0001764_abnormal_homeostasis	1.37712084
33	MP0005551_abnormal_eye_electrophysiolog	1.36701595
34	MP0001835_abnormal_antigen_presentation	1.29001432
35	MP0004147_increased_porphyrin_level	1.27101922
36	MP0002095_abnormal_skin_pigmentation	1.26688534
37	MP0003693_abnormal_embryo_hatching	1.25192392
38	MP0000015_abnormal_ear_pigmentation	1.23122294
39	MP0005075_abnormal_melanosome_morpholog	1.22982102
40	MP0001293_anophthalmia	1.21682656
41	MP0001905_abnormal_dopamine_level	1.20586790
42	MP0002876_abnormal_thyroid_physiology	1.19343516
43	MP0002837_dystrophic_cardiac_calcinosis	1.19014231
44	MP0000631_abnormal_neuroendocrine_gland	1.18845367
45	MP0001968_abnormal_touch/_nociception	1.16499214
46	MP0006276_abnormal_autonomic_nervous	1.16185474
47	MP0005253_abnormal_eye_physiology	1.15570705
48	MP0003121_genomic_imprinting	1.09392692
49	MP0010094_abnormal_chromosome_stability	1.07680397
50	MP0001501_abnormal_sleep_pattern	1.07652524
51	MP0005174_abnormal_tail_pigmentation	1.06277164
52	MP0009764_decreased_sensitivity_to	1.04564476
53	MP0005365_abnormal_bile_salt	1.04478860
54	MP0002160_abnormal_reproductive_system	1.02336696
55	MP0003315_abnormal_perineum_morphology	1.01766051
56	MP0000569_abnormal_digit_pigmentation	1.01750796
57	MP0002557_abnormal_social/conspecific_i	1.00810834
58	MP0005670_abnormal_white_adipose	1.00337686
59	MP0001529_abnormal_vocalization	1.00041172
60	MP0004043_abnormal_pH_regulation	0.99573787
61	MP0005377_hearing/vestibular/ear_phenot	0.98940225
62	MP0003878_abnormal_ear_physiology	0.98940225
63	MP0009745_abnormal_behavioral_response	0.98747431
64	MP0003011_delayed_dark_adaptation	0.98601972
65	MP0005636_abnormal_mineral_homeostasis	0.97551740
66	MP0006036_abnormal_mitochondrial_physio	0.97266694
67	MP0002102_abnormal_ear_morphology	0.97200439
68	MP0009046_muscle_twitch	0.96059151
69	MP0005332_abnormal_amino_acid	0.95006425
70	MP0003724_increased_susceptibility_to	0.94203753
71	MP0002272_abnormal_nervous_system	0.94169875
72	MP0001486_abnormal_startle_reflex	0.92989109
73	MP0002277_abnormal_respiratory_mucosa	0.92928564
74	MP0005389_reproductive_system_phenotype	0.90404249
75	MP0001663_abnormal_digestive_system	0.89529511
76	MP0004885_abnormal_endolymph	0.89104752
77	MP0005464_abnormal_platelet_physiology	0.88062578
78	MP0005410_abnormal_fertilization	0.85936902
79	MP0003122_maternal_imprinting	0.85805507
80	MP0003136_yellow_coat_color	0.82015539
81	MP0002184_abnormal_innervation	0.81809353
82	MP0001970_abnormal_pain_threshold	0.80736135
83	MP0001485_abnormal_pinna_reflex	0.79492225
84	MP0001881_abnormal_mammary_gland	0.78143233
85	MP0001919_abnormal_reproductive_system	0.78087999
86	MP0003786_premature_aging	0.77230652
87	MP0008004_abnormal_stomach_pH	0.77097773
88	MP0000653_abnormal_sex_gland	0.77035788
89	MP0000230_abnormal_systemic_arterial	0.76028318
90	MP0001664_abnormal_digestion	0.74556862
91	MP0001986_abnormal_taste_sensitivity	0.72835341
92	MP0002210_abnormal_sex_determination	0.72313445
93	MP0003183_abnormal_peptide_metabolism	0.70239830
94	MP0009697_abnormal_copulation	0.70127233
95	MP0002928_abnormal_bile_duct	0.69984815
96	MP0001119_abnormal_female_reproductive	0.69614938
97	MP0005395_other_phenotype	0.68998617
98	MP0003880_abnormal_central_pattern	0.68900308
99	MP0003959_abnormal_lean_body	0.68802250
100	MP0001873_stomach_inflammation	0.67695893

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.47413084
2	Acute encephalopathy (HP:0006846)	4.03305034
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.99092728
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.61334939
5	Cerebral edema (HP:0002181)	3.57243570
6	Progressive macrocephaly (HP:0004481)	3.54750815
7	Increased CSF lactate (HP:0002490)	3.49725325
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.46676795
9	Mitochondrial inheritance (HP:0001427)	3.46410992
10	Reticulocytopenia (HP:0001896)	3.44926917
11	Abnormal number of erythroid precursors (HP:0012131)	3.40749744
12	Nephronophthisis (HP:0000090)	3.17020315
13	Congenital stationary night blindness (HP:0007642)	3.14726152
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.04789390
15	Abnormality of midbrain morphology (HP:0002418)	2.99598325
16	Molar tooth sign on MRI (HP:0002419)	2.99598325
17	3-Methylglutaconic aciduria (HP:0003535)	2.91045988
18	Hepatic necrosis (HP:0002605)	2.87884275
19	Type II lissencephaly (HP:0007260)	2.86439096
20	Microvesicular hepatic steatosis (HP:0001414)	2.85944797
21	Pancreatic cysts (HP:0001737)	2.85535062
22	Abnormality of the renal medulla (HP:0100957)	2.84444249
23	Hepatocellular necrosis (HP:0001404)	2.78209772
24	Abnormality of the renal cortex (HP:0011035)	2.77031884
25	Pancreatic fibrosis (HP:0100732)	2.75444050
26	Pendular nystagmus (HP:0012043)	2.67762970
27	Colon cancer (HP:0003003)	2.62480974
28	Agitation (HP:0000713)	2.60011560
29	Medial flaring of the eyebrow (HP:0010747)	2.58348143
30	Lactic acidosis (HP:0003128)	2.56664635
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.53175063
32	Optic nerve hypoplasia (HP:0000609)	2.52967237
33	Increased serum lactate (HP:0002151)	2.51566185
34	Optic disc pallor (HP:0000543)	2.46545876
35	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.41387668
36	Septo-optic dysplasia (HP:0100842)	2.40569168
37	Asplenia (HP:0001746)	2.37285945
38	Lipid accumulation in hepatocytes (HP:0006561)	2.35064670
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.33085420
40	Type 2 muscle fiber atrophy (HP:0003554)	2.31937066
41	Macrocytic anemia (HP:0001972)	2.29738226
42	Neoplasm of the adrenal cortex (HP:0100641)	2.27250301
43	Increased hepatocellular lipid droplets (HP:0006565)	2.24041239
44	Methylmalonic aciduria (HP:0012120)	2.18986080
45	Dicarboxylic aciduria (HP:0003215)	2.18051285
46	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.18051285
47	Severe visual impairment (HP:0001141)	2.18025989
48	Stomatitis (HP:0010280)	2.17830193
49	Abnormality of the pons (HP:0007361)	2.15109131
50	Exercise intolerance (HP:0003546)	2.14635990
51	Sclerocornea (HP:0000647)	2.13326243
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.12320855
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.12320855
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09729025
55	True hermaphroditism (HP:0010459)	2.07323737
56	Decreased central vision (HP:0007663)	2.06316626
57	Hypoplasia of the pons (HP:0012110)	2.06159911
58	Attenuation of retinal blood vessels (HP:0007843)	2.03144202
59	Lethargy (HP:0001254)	2.02666712
60	Meckel diverticulum (HP:0002245)	2.02583692
61	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01985713
62	Chromsome breakage (HP:0040012)	1.99763284
63	Cerebellar dysplasia (HP:0007033)	1.97213713
64	Abnormality of the ileum (HP:0001549)	1.96971534
65	Muscle fiber atrophy (HP:0100295)	1.95081990
66	Respiratory failure (HP:0002878)	1.94923102
67	Polydipsia (HP:0001959)	1.94199644
68	Abnormal drinking behavior (HP:0030082)	1.94199644
69	Type I transferrin isoform profile (HP:0003642)	1.93376736
70	Pachygyria (HP:0001302)	1.91189089
71	Tubular atrophy (HP:0000092)	1.90468056
72	Stenosis of the external auditory canal (HP:0000402)	1.86555630
73	Ketosis (HP:0001946)	1.84634771
74	Leukodystrophy (HP:0002415)	1.84531612
75	Absent thumb (HP:0009777)	1.84060075
76	Increased intramyocellular lipid droplets (HP:0012240)	1.83875587
77	Generalized aminoaciduria (HP:0002909)	1.83765312
78	Chronic hepatic failure (HP:0100626)	1.82636881
79	Pallor (HP:0000980)	1.81063539
80	Renal cortical cysts (HP:0000803)	1.78431010
81	Abnormality of the renal collecting system (HP:0004742)	1.77699723
82	Bile duct proliferation (HP:0001408)	1.75075025
83	Abnormal biliary tract physiology (HP:0012439)	1.75075025
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74164241
85	Increased corneal curvature (HP:0100692)	1.73969856
86	Keratoconus (HP:0000563)	1.73969856
87	Lissencephaly (HP:0001339)	1.73012921
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.72949844
89	Renal Fanconi syndrome (HP:0001994)	1.71202504
90	Polyuria (HP:0000103)	1.69868216
91	Abnormality of the preputium (HP:0100587)	1.69161814
92	Exertional dyspnea (HP:0002875)	1.69155840
93	Abnormality of urine glucose concentration (HP:0011016)	1.67954021
94	Glycosuria (HP:0003076)	1.67954021
95	Horseshoe kidney (HP:0000085)	1.67353583
96	Rib fusion (HP:0000902)	1.67126829
97	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.65604599
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.65604599
99	Abnormal protein glycosylation (HP:0012346)	1.65604599
100	Abnormal glycosylation (HP:0012345)	1.65604599

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.52122088
2	ZAK	3.26702811
3	VRK2	2.74588624
4	ARAF	2.65001064
5	BMPR1B	2.38590615
6	GRK1	2.34030061
7	WNK4	2.09954629
8	PIM2	2.09868683
9	TEC	2.08080088
10	BRAF	2.08068915
11	NEK1	2.00226962
12	ADRBK2	1.97511770
13	SRPK1	1.92028557
14	NUAK1	1.87383364
15	FRK	1.78131770
16	DYRK2	1.77104226
17	BCKDK	1.64905736
18	AKT3	1.54046830
19	TXK	1.52813554
20	STK39	1.44714271
21	NME1	1.43798252
22	VRK1	1.39033938
23	PLK4	1.30843717
24	PBK	1.28362779
25	TNK2	1.25979989
26	FLT3	1.22694059
27	PLK3	1.18908648
28	OXSR1	1.15417221
29	MARK1	1.14817229
30	IKBKB	1.13591711
31	TIE1	1.10226336
32	TAOK3	1.09617625
33	EIF2AK1	1.05593752
34	ACVR1B	1.04710892
35	PDK2	1.03519558
36	PHKG2	1.01475140
37	PHKG1	1.01475140
38	TAF1	1.00517395
39	WNK3	0.99882420
40	MAP4K2	0.99458379
41	TSSK6	0.97887064
42	TLK1	0.97304383
43	PAK3	0.97234962
44	NME2	0.95373132
45	TGFBR1	0.92473587
46	CDC7	0.87656326
47	TRIM28	0.87246116
48	MAPK13	0.85939604
49	PTK2B	0.85626705
50	CDK8	0.85429404
51	PRKCG	0.85129355
52	ADRBK1	0.84328682
53	PLK1	0.81428557
54	GRK5	0.81148767
55	PRKCI	0.80136196
56	DYRK3	0.80028065
57	CSNK1G2	0.78813000
58	MUSK	0.78776161
59	MKNK2	0.78330454
60	CSNK1G3	0.75455011
61	RPS6KA5	0.75115669
62	LMTK2	0.68008591
63	ICK	0.67606512
64	GRK7	0.67398668
65	RPS6KA6	0.67116251
66	MAPKAPK5	0.66556417
67	INSRR	0.65955112
68	EPHA4	0.65924068
69	MKNK1	0.65441030
70	ITK	0.63965630
71	CSNK1G1	0.63393639
72	ABL2	0.63207468
73	PIK3CG	0.61887028
74	PRKCQ	0.61842199
75	CHEK2	0.61740209
76	CSNK1A1L	0.60943558
77	PLK2	0.60855956
78	ATR	0.60331453
79	MST4	0.58439461
80	PINK1	0.52693937
81	PKN1	0.51370992
82	MAPKAPK3	0.51003068
83	RPS6KL1	0.50997481
84	RPS6KC1	0.50997481
85	KDR	0.50901089
86	DMPK	0.49657579
87	MAP3K4	0.47048784
88	PIK3CA	0.45633437
89	BUB1	0.44544669
90	CAMKK2	0.44448905
91	TNIK	0.44027540
92	CDK19	0.43873300
93	MAP4K1	0.43206100
94	AURKB	0.41517239
95	CSNK2A1	0.40899453
96	CCNB1	0.40869088
97	WNK1	0.40624366
98	PRKACA	0.40537579
99	PRKCE	0.40306940
100	CSNK2A2	0.39878656

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.62773476
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.32534180
3	Parkinsons disease_Homo sapiens_hsa05012	2.87674633
4	Proteasome_Homo sapiens_hsa03050	2.73067132
5	Asthma_Homo sapiens_hsa05310	2.65434696
6	RNA polymerase_Homo sapiens_hsa03020	2.46218843
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29211374
8	Homologous recombination_Homo sapiens_hsa03440	2.28495890
9	Protein export_Homo sapiens_hsa03060	2.28416950
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26663261
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95753131
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95701396
13	Caffeine metabolism_Homo sapiens_hsa00232	1.94396321
14	Huntingtons disease_Homo sapiens_hsa05016	1.91247051
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90169240
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.82513938
17	Peroxisome_Homo sapiens_hsa04146	1.74624781
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71284106
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71255010
20	Mismatch repair_Homo sapiens_hsa03430	1.69496101
21	Alzheimers disease_Homo sapiens_hsa05010	1.66017235
22	Allograft rejection_Homo sapiens_hsa05330	1.61237833
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57730561
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57048972
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56893131
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54541335
27	Butanoate metabolism_Homo sapiens_hsa00650	1.52676224
28	RNA degradation_Homo sapiens_hsa03018	1.50085945
29	Propanoate metabolism_Homo sapiens_hsa00640	1.50004455
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.48015571
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41288196
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.38053155
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34511386
34	Fatty acid degradation_Homo sapiens_hsa00071	1.33039920
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.30614964
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.29889099
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.29148528
38	Sulfur relay system_Homo sapiens_hsa04122	1.28874135
39	Phototransduction_Homo sapiens_hsa04744	1.26173570
40	DNA replication_Homo sapiens_hsa03030	1.26062763
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.23137754
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19422407
43	Basal transcription factors_Homo sapiens_hsa03022	1.18517927
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15029986
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.14155213
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13795171
47	Graft-versus-host disease_Homo sapiens_hsa05332	1.10173034
48	Fatty acid elongation_Homo sapiens_hsa00062	1.03634466
49	Base excision repair_Homo sapiens_hsa03410	1.01341344
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.99159788
51	Purine metabolism_Homo sapiens_hsa00230	0.98540674
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98404033
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95842742
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95515093
55	One carbon pool by folate_Homo sapiens_hsa00670	0.92370800
56	Retinol metabolism_Homo sapiens_hsa00830	0.91821845
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89198887
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.88352748
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87735878
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87420729
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84510575
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.82967021
63	RNA transport_Homo sapiens_hsa03013	0.81527137
64	Metabolic pathways_Homo sapiens_hsa01100	0.79583199
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79505833
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78094299
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.72227085
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70163162
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69578550
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68331561
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67277744
72	Sulfur metabolism_Homo sapiens_hsa00920	0.66773172
73	Olfactory transduction_Homo sapiens_hsa04740	0.66734822
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65696765
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64893739
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64842777
77	Spliceosome_Homo sapiens_hsa03040	0.62107559
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60066489
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57563330
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56659527
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55890426
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55162286
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53425720
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53318356
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46269111
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.44952354
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43001776
88	Serotonergic synapse_Homo sapiens_hsa04726	0.41895951
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38235525
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34455404
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34169978
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.32952753
93	Glutathione metabolism_Homo sapiens_hsa00480	0.32009112
94	Morphine addiction_Homo sapiens_hsa05032	0.31511381
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.31266684
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27463541
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.27055792
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.24279146
99	Nicotine addiction_Homo sapiens_hsa05033	0.21013875
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.18310994

RPS7P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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