RPS7P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.77609380
2ribosomal large subunit biogenesis (GO:0042273)7.05541612
3viral transcription (GO:0019083)6.72838005
4translational termination (GO:0006415)6.52460981
5ribosomal small subunit biogenesis (GO:0042274)6.27982214
6ATP synthesis coupled proton transport (GO:0015986)5.85331615
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85331615
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.53104829
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.51537283
10translational elongation (GO:0006414)5.47813165
11protein targeting to ER (GO:0045047)5.40851101
12cotranslational protein targeting to membrane (GO:0006613)5.40643280
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.17552450
14protein localization to endoplasmic reticulum (GO:0070972)5.05756971
15cellular protein complex disassembly (GO:0043624)4.85420681
16maturation of SSU-rRNA (GO:0030490)4.85174941
17viral life cycle (GO:0019058)4.76828914
18piRNA metabolic process (GO:0034587)4.68530388
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.66158426
20protein neddylation (GO:0045116)4.64007424
21peptidyl-histidine modification (GO:0018202)4.45451914
22response to pheromone (GO:0019236)4.39869284
23translational initiation (GO:0006413)4.37017059
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32768760
25protein complex disassembly (GO:0043241)3.99236755
26respiratory electron transport chain (GO:0022904)3.95201563
27electron transport chain (GO:0022900)3.93657086
28behavioral response to nicotine (GO:0035095)3.91056663
29DNA deamination (GO:0045006)3.90689997
30translation (GO:0006412)3.90171559
31ribonucleoprotein complex biogenesis (GO:0022613)3.89131328
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.80040689
33macromolecular complex disassembly (GO:0032984)3.78616780
34cellular component biogenesis (GO:0044085)3.58293551
35chaperone-mediated protein transport (GO:0072321)3.56150331
36protein targeting to membrane (GO:0006612)3.52651738
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47158376
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47158376
39ATP biosynthetic process (GO:0006754)3.46936453
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.46068585
41negative regulation of mast cell activation (GO:0033004)3.45932584
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43932035
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.43834957
44GTP biosynthetic process (GO:0006183)3.34418044
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33726372
46protein complex biogenesis (GO:0070271)3.27393488
47glycerophospholipid catabolic process (GO:0046475)3.26909909
48mRNA catabolic process (GO:0006402)3.22670617
49termination of RNA polymerase III transcription (GO:0006386)3.19305651
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.19305651
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.18805265
52mitochondrial respiratory chain complex assembly (GO:0033108)3.17214293
53positive regulation of interleukin-17 production (GO:0032740)3.16559770
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16096117
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.16096117
56NADH dehydrogenase complex assembly (GO:0010257)3.16096117
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15820982
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13996348
59hydrogen ion transmembrane transport (GO:1902600)3.12008772
60pyrimidine nucleobase catabolic process (GO:0006208)3.07370294
61rRNA processing (GO:0006364)2.99052701
62male meiosis I (GO:0007141)2.98615794
63RNA catabolic process (GO:0006401)2.92803307
64leukotriene biosynthetic process (GO:0019370)2.91309885
65rRNA metabolic process (GO:0016072)2.89776980
66nonribosomal peptide biosynthetic process (GO:0019184)2.89760121
67respiratory chain complex IV assembly (GO:0008535)2.89751462
68transcription from mitochondrial promoter (GO:0006390)2.89695209
69ribonucleoside triphosphate biosynthetic process (GO:0009201)2.88977245
70proton transport (GO:0015992)2.86365170
71seminiferous tubule development (GO:0072520)2.85938985
72hydrogen transport (GO:0006818)2.78839497
73pseudouridine synthesis (GO:0001522)2.75290469
74glutathione biosynthetic process (GO:0006750)2.73696403
75indolalkylamine metabolic process (GO:0006586)2.73330013
76positive regulation of mitochondrial fission (GO:0090141)2.72739487
77tRNA processing (GO:0008033)2.67181712
78protein-cofactor linkage (GO:0018065)2.67060927
79UTP biosynthetic process (GO:0006228)2.64050971
80ribosome assembly (GO:0042255)2.62268331
81mitochondrial calcium ion transport (GO:0006851)2.57948226
82proteasome assembly (GO:0043248)2.57427990
83nucleobase catabolic process (GO:0046113)2.56332618
84maturation of 5.8S rRNA (GO:0000460)2.55050572
85protein targeting to mitochondrion (GO:0006626)2.54308538
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52480721
87UTP metabolic process (GO:0046051)2.52025818
88oxidative phosphorylation (GO:0006119)2.51806384
89dopamine transport (GO:0015872)2.51777927
90nucleoside triphosphate biosynthetic process (GO:0009142)2.50389891
91regulation of activation of Janus kinase activity (GO:0010533)2.49443718
92intracellular protein transmembrane import (GO:0044743)2.48273276
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48253454
94protein targeting (GO:0006605)2.46603172
95cytochrome complex assembly (GO:0017004)2.46571064
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.46349239
97negative regulation of telomere maintenance (GO:0032205)2.46113291
98meiosis I (GO:0007127)2.45576961
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44923035
100phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.43506419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.10815666
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09352842
3EZH2_22144423_ChIP-Seq_EOC_Human3.35872898
4ZNF274_21170338_ChIP-Seq_K562_Hela3.20290050
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.12292958
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.08034911
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.03986292
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92782768
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.78409816
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73727848
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42481368
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30325773
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18798293
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17597571
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10746045
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02621034
17FUS_26573619_Chip-Seq_HEK293_Human1.99510686
18IGF1R_20145208_ChIP-Seq_DFB_Human1.97477978
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93500217
20VDR_23849224_ChIP-Seq_CD4+_Human1.86581735
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82712480
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81779541
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.78155516
24EWS_26573619_Chip-Seq_HEK293_Human1.77714041
25ELK1_19687146_ChIP-ChIP_HELA_Human1.76090339
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67023784
27MYC_18940864_ChIP-ChIP_HL60_Human1.63982268
28FOXP3_21729870_ChIP-Seq_TREG_Human1.60920597
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57430190
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.56641028
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.53192740
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.52370251
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46493576
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45826682
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42971246
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41023799
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40641542
38CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.39994264
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.38513217
40NCOR_22424771_ChIP-Seq_293T_Human1.37513996
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36481188
42GBX2_23144817_ChIP-Seq_PC3_Human1.35619868
43NANOG_20526341_ChIP-Seq_ESCs_Human1.33886353
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33072333
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.30274589
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30274589
47P300_19829295_ChIP-Seq_ESCs_Human1.29913364
48TTF2_22483619_ChIP-Seq_HELA_Human1.27984725
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26887701
50RNF2_27304074_Chip-Seq_NSC_Mouse1.21777340
51SOX2_19829295_ChIP-Seq_ESCs_Human1.21061854
52NANOG_19829295_ChIP-Seq_ESCs_Human1.21061854
53ER_23166858_ChIP-Seq_MCF-7_Human1.19385427
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18913025
55AR_20517297_ChIP-Seq_VCAP_Human1.17863474
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17769188
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.17739348
58TP53_22573176_ChIP-Seq_HFKS_Human1.16136347
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15760105
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.15044385
61CBP_20019798_ChIP-Seq_JUKART_Human1.13994759
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13994759
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12072329
64REST_21632747_ChIP-Seq_MESCs_Mouse1.12065284
65ERA_21632823_ChIP-Seq_H3396_Human1.11436564
66IRF1_19129219_ChIP-ChIP_H3396_Human1.10929104
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09100621
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06344479
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05580646
70MYC_19829295_ChIP-Seq_ESCs_Human1.04876962
71ERG_20517297_ChIP-Seq_VCAP_Human1.04090581
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.03915622
73TAF2_19829295_ChIP-Seq_ESCs_Human1.03677612
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03103501
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02268710
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01903274
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.01678562
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98852196
79TP63_19390658_ChIP-ChIP_HaCaT_Human0.98283932
80BCAT_22108803_ChIP-Seq_LS180_Human0.98052603
81TAF15_26573619_Chip-Seq_HEK293_Human0.97530446
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97448661
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97315915
84EZH2_27294783_Chip-Seq_ESCs_Mouse0.94878005
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93662671
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93122005
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92299822
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91211930
89CTCF_20526341_ChIP-Seq_ESCs_Human0.90841575
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.90241327
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90214040
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89399810
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.88358735
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87909298
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.86489650
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85022356
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84860069
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84785644
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83699465
100HOXB7_26014856_ChIP-Seq_BT474_Human0.83028246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.50724522
2MP0006292_abnormal_olfactory_placode3.47407136
3MP0005646_abnormal_pituitary_gland2.77261998
4MP0004142_abnormal_muscle_tone2.63433569
5MP0002638_abnormal_pupillary_reflex2.55932508
6MP0003195_calcinosis2.54023480
7MP0003646_muscle_fatigue2.49731694
8MP0003787_abnormal_imprinting2.12225664
9MP0002163_abnormal_gland_morphology2.10136492
10MP0002837_dystrophic_cardiac_calcinosis2.05213862
11MP0002102_abnormal_ear_morphology2.05129803
12MP0005645_abnormal_hypothalamus_physiol1.97800170
13MP0001986_abnormal_taste_sensitivity1.94064549
14MP0001968_abnormal_touch/_nociception1.92947397
15MP0005671_abnormal_response_to1.92167464
16MP0001905_abnormal_dopamine_level1.88861233
17MP0003786_premature_aging1.82941493
18MP0008877_abnormal_DNA_methylation1.81749686
19MP0002876_abnormal_thyroid_physiology1.75954242
20MP0008789_abnormal_olfactory_epithelium1.75715481
21MP0008872_abnormal_physiological_respon1.74835132
22MP0002272_abnormal_nervous_system1.73593035
23MP0005075_abnormal_melanosome_morpholog1.73193098
24MP0000631_abnormal_neuroendocrine_gland1.72141956
25MP0008995_early_reproductive_senescence1.68511123
26MP0001529_abnormal_vocalization1.66642323
27MP0008875_abnormal_xenobiotic_pharmacok1.64517167
28MP0004133_heterotaxia1.64496748
29MP0006072_abnormal_retinal_apoptosis1.63397478
30MP0002736_abnormal_nociception_after1.60610825
31MP0004147_increased_porphyrin_level1.54572102
32MP0006276_abnormal_autonomic_nervous1.54069654
33MP0005379_endocrine/exocrine_gland_phen1.52834882
34MP0003011_delayed_dark_adaptation1.44682975
35MP0005551_abnormal_eye_electrophysiolog1.42776313
36MP0009745_abnormal_behavioral_response1.41911604
37MP0002733_abnormal_thermal_nociception1.41306153
38MP0009046_muscle_twitch1.38969231
39MP0003880_abnormal_central_pattern1.37579879
40MP0010386_abnormal_urinary_bladder1.28349449
41MP0004742_abnormal_vestibular_system1.26474436
42MP0002572_abnormal_emotion/affect_behav1.25848617
43MP0001970_abnormal_pain_threshold1.25551149
44MP0008775_abnormal_heart_ventricle1.23847482
45MP0009333_abnormal_splenocyte_physiolog1.23160072
46MP0005499_abnormal_olfactory_system1.21558049
47MP0005394_taste/olfaction_phenotype1.21558049
48MP0000372_irregular_coat_pigmentation1.21369298
49MP0001835_abnormal_antigen_presentation1.21139430
50MP0006035_abnormal_mitochondrial_morpho1.21044078
51MP0002735_abnormal_chemical_nociception1.20484196
52MP0003122_maternal_imprinting1.17057992
53MP0004885_abnormal_endolymph1.15521974
54MP0006036_abnormal_mitochondrial_physio1.12092458
55MP0002938_white_spotting1.11259284
56MP0002557_abnormal_social/conspecific_i1.11253987
57MP0005389_reproductive_system_phenotype1.09163417
58MP0000049_abnormal_middle_ear1.08934563
59MP0005084_abnormal_gallbladder_morpholo1.08707394
60MP0001764_abnormal_homeostasis1.07496998
61MP0001501_abnormal_sleep_pattern1.05175741
62MP0003121_genomic_imprinting1.03321166
63MP0004043_abnormal_pH_regulation1.02176846
64MP0005253_abnormal_eye_physiology1.01143095
65MP0005174_abnormal_tail_pigmentation1.00353268
66MP0002234_abnormal_pharynx_morphology0.98074216
67MP0001919_abnormal_reproductive_system0.97837954
68MP0001293_anophthalmia0.96820286
69MP0002210_abnormal_sex_determination0.95894827
70MP0003635_abnormal_synaptic_transmissio0.94295947
71MP0003878_abnormal_ear_physiology0.94240665
72MP0005377_hearing/vestibular/ear_phenot0.94240665
73MP0005670_abnormal_white_adipose0.92240901
74MP0002064_seizures0.90607079
75MP0002229_neurodegeneration0.90467946
76MP0001486_abnormal_startle_reflex0.89552754
77MP0002160_abnormal_reproductive_system0.89195224
78MP0002184_abnormal_innervation0.89018575
79MP0002063_abnormal_learning/memory/cond0.88123311
80MP0005535_abnormal_body_temperature0.87012628
81MP0001324_abnormal_eye_pigmentation0.81572459
82MP0003567_abnormal_fetal_cardiomyocyte0.81349222
83MP0003806_abnormal_nucleotide_metabolis0.81259264
84MP0001502_abnormal_circadian_rhythm0.81190154
85MP0002277_abnormal_respiratory_mucosa0.80996013
86MP0001929_abnormal_gametogenesis0.80874265
87MP0003718_maternal_effect0.77778180
88MP0001485_abnormal_pinna_reflex0.75914013
89MP0008058_abnormal_DNA_repair0.75765721
90MP0003137_abnormal_impulse_conducting0.75256744
91MP0005410_abnormal_fertilization0.74679576
92MP0009785_altered_susceptibility_to0.74217119
93MP0005195_abnormal_posterior_eye0.74046305
94MP0008007_abnormal_cellular_replicative0.73296853
95MP0003283_abnormal_digestive_organ0.72828538
96MP0002138_abnormal_hepatobiliary_system0.72390587
97MP0002752_abnormal_somatic_nervous0.72381007
98MP0001119_abnormal_female_reproductive0.72021901
99MP0003698_abnormal_male_reproductive0.71921648
100MP0003938_abnormal_ear_development0.71523657

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.50511567
2Macrocytic anemia (HP:0001972)4.34336009
3Abnormal mitochondria in muscle tissue (HP:0008316)4.14104115
4Abnormality of cells of the erythroid lineage (HP:0012130)4.00295087
5Reticulocytopenia (HP:0001896)3.99079479
6Acute encephalopathy (HP:0006846)3.84836472
7Mitochondrial inheritance (HP:0001427)3.79552417
8Molar tooth sign on MRI (HP:0002419)3.76711503
9Abnormality of midbrain morphology (HP:0002418)3.76711503
10Progressive macrocephaly (HP:0004481)3.66059066
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.54909063
123-Methylglutaconic aciduria (HP:0003535)3.54410262
13Congenital stationary night blindness (HP:0007642)3.51389112
14Increased CSF lactate (HP:0002490)3.41048841
15Abnormal hemoglobin (HP:0011902)3.38225200
16Pancreatic fibrosis (HP:0100732)3.35333692
17Abnormal rod and cone electroretinograms (HP:0008323)3.35015135
18Abnormal number of erythroid precursors (HP:0012131)3.23252165
19Chronic hepatic failure (HP:0100626)3.14615520
20Central scotoma (HP:0000603)3.13954703
21Pancreatic cysts (HP:0001737)3.12915858
22Abnormal biliary tract physiology (HP:0012439)3.01011623
23Bile duct proliferation (HP:0001408)3.01011623
24Pallor (HP:0000980)3.00746252
25True hermaphroditism (HP:0010459)2.96527224
26Cerebral edema (HP:0002181)2.88700033
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83844755
28Abnormality of alanine metabolism (HP:0010916)2.83844755
29Hyperalaninemia (HP:0003348)2.83844755
30Increased hepatocellular lipid droplets (HP:0006565)2.81361133
31Absent/shortened dynein arms (HP:0200106)2.79433664
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.79433664
33Optic disc pallor (HP:0000543)2.74867459
34Triphalangeal thumb (HP:0001199)2.64395304
35Abolished electroretinogram (ERG) (HP:0000550)2.55298170
36Lipid accumulation in hepatocytes (HP:0006561)2.52760695
37Abnormality of homocysteine metabolism (HP:0010919)2.42949192
38Homocystinuria (HP:0002156)2.42949192
39Renal Fanconi syndrome (HP:0001994)2.42050936
40Dyschromatopsia (HP:0007641)2.39466828
41Hepatocellular necrosis (HP:0001404)2.38142435
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37331406
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37331406
44Increased intramyocellular lipid droplets (HP:0012240)2.33198813
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31702086
46Increased serum lactate (HP:0002151)2.25119723
47Abnormal drinking behavior (HP:0030082)2.24603952
48Polydipsia (HP:0001959)2.24603952
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.23616350
50Pendular nystagmus (HP:0012043)2.23527713
51Stomatitis (HP:0010280)2.21989820
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21916409
53Nephronophthisis (HP:0000090)2.20380864
54Constricted visual fields (HP:0001133)2.20164595
55Decreased central vision (HP:0007663)2.19569228
56Lactic acidosis (HP:0003128)2.19145288
57Supernumerary spleens (HP:0009799)2.15580515
58Attenuation of retinal blood vessels (HP:0007843)2.15354013
59Optic nerve coloboma (HP:0000588)2.14558286
60Anencephaly (HP:0002323)2.12688281
61Brushfield spots (HP:0001088)2.11960792
62Severe visual impairment (HP:0001141)2.11839086
63Meckel diverticulum (HP:0002245)2.11784370
64Hepatic necrosis (HP:0002605)2.11439099
65Leukodystrophy (HP:0002415)2.10157605
66Abnormality of the ileum (HP:0001549)2.10035940
67Medial flaring of the eyebrow (HP:0010747)2.09830242
68Lethargy (HP:0001254)2.08452050
69Stenosis of the external auditory canal (HP:0000402)2.07431163
70Elevated erythrocyte sedimentation rate (HP:0003565)2.06338162
71Cystic liver disease (HP:0006706)2.04339721
72Absent thumb (HP:0009777)2.01667808
73Microvesicular hepatic steatosis (HP:0001414)2.00161363
74Abnormality of the renal cortex (HP:0011035)1.99509989
75Congenital hepatic fibrosis (HP:0002612)1.96445728
76Depressed nasal ridge (HP:0000457)1.96252277
77Abnormality of the preputium (HP:0100587)1.93566648
78Exertional dyspnea (HP:0002875)1.92705306
79Abnormality of serum amino acid levels (HP:0003112)1.92480937
80Congenital, generalized hypertrichosis (HP:0004540)1.91410169
81Abnormality of the renal medulla (HP:0100957)1.88674298
82Sclerocornea (HP:0000647)1.86788790
83Increased muscle lipid content (HP:0009058)1.86563435
84Respiratory failure (HP:0002878)1.86548855
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85661869
86Hyperglycinuria (HP:0003108)1.85414496
87IgG deficiency (HP:0004315)1.84385046
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81163342
89Abnormality of urine glucose concentration (HP:0011016)1.80266522
90Glycosuria (HP:0003076)1.80266522
91Abnormal respiratory motile cilium morphology (HP:0005938)1.80244930
92Abnormal respiratory epithelium morphology (HP:0012253)1.80244930
93Asplenia (HP:0001746)1.78702657
94Clubbing of toes (HP:0100760)1.78495141
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.78170330
96Abnormality of macular pigmentation (HP:0008002)1.77361507
97Keratoconus (HP:0000563)1.77101057
98Increased corneal curvature (HP:0100692)1.77101057
99Scotoma (HP:0000575)1.74440558
100Myokymia (HP:0002411)1.74347018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.68388562
2MAP4K23.00692729
3CDK192.73997773
4ADRBK22.51228375
5NUAK12.46230864
6TLK12.38145157
7ZAK2.30885247
8TIE12.15982091
9BCKDK2.11225473
10GRK12.04582096
11DAPK21.95765713
12TEC1.95348708
13TRIM281.95205887
14KDR1.94123655
15WNK31.88113936
16MAP3K121.82559663
17NME21.80043144
18DYRK21.79899792
19CAMKK21.75997919
20TNK21.70171838
21WNK41.61335772
22MAP2K61.55052833
23LIMK11.53568858
24MAP3K111.42505100
25VRK11.38954624
26TXK1.38051666
27FRK1.37270017
28VRK21.31659553
29RPS6KB21.31080925
30INSRR1.22299209
31BMPR1B1.21468382
32MINK11.21297311
33TAOK31.20495863
34DAPK11.20341905
35OXSR11.16657813
36CSF1R1.16000960
37MAP4K11.11446972
38STK161.10890435
39ITK1.09264035
40PLK41.03131513
41KIT1.01930539
42CDC71.01488575
43DAPK30.99325883
44CAMKK10.97923516
45CDK80.97426827
46BUB10.94618667
47STK390.94006254
48MAPK130.93756783
49ACVR1B0.93186517
50CSNK1G20.92032905
51FES0.90158312
52NTRK30.86015743
53CSNK1G30.85229699
54EPHA40.82058811
55IKBKB0.81220861
56PASK0.76785261
57PRKCG0.75875550
58PHKG10.75808383
59PHKG20.75808383
60ADRBK10.75722067
61RPS6KA60.73799405
62CASK0.73472731
63SYK0.73441780
64PRKCQ0.71556457
65MKNK10.70045661
66TAF10.68779426
67MST40.66158720
68PAK60.65849781
69CAMK10.64664981
70CSNK1G10.63125394
71RPS6KL10.59869376
72RPS6KC10.59869376
73CDK30.58156529
74RPS6KB10.57522787
75CSNK2A20.57088417
76PRKCE0.56895375
77CAMK2A0.56344259
78RPS6KA50.55104505
79BTK0.55006683
80TYRO30.51823329
81PIK3CA0.51254208
82MAP2K70.50108278
83PRKCH0.49883074
84ILK0.49192601
85CSNK1A1L0.48601960
86MAP3K50.47693560
87PRKG20.46894048
88PRKG10.46736245
89TGFBR10.46695255
90MAPKAPK50.45818498
91LRRK20.45668473
92RPS6KA40.45611274
93NTRK20.44632942
94PRKACA0.44210527
95ABL20.43609357
96PIK3CG0.43192759
97NME10.42569765
98CSNK1A10.42180036
99OBSCN0.41603191
100LCK0.41271429

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.61799420
2Oxidative phosphorylation_Homo sapiens_hsa001904.10364396
3Parkinsons disease_Homo sapiens_hsa050123.43551512
4Proteasome_Homo sapiens_hsa030502.65372150
5Asthma_Homo sapiens_hsa053102.54376927
6Selenocompound metabolism_Homo sapiens_hsa004502.52984371
7Alzheimers disease_Homo sapiens_hsa050102.31947792
8Huntingtons disease_Homo sapiens_hsa050162.21384941
9RNA polymerase_Homo sapiens_hsa030202.14294572
10Cardiac muscle contraction_Homo sapiens_hsa042602.13804583
11Allograft rejection_Homo sapiens_hsa053302.11068992
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06904489
13One carbon pool by folate_Homo sapiens_hsa006702.06281233
14Linoleic acid metabolism_Homo sapiens_hsa005911.98149864
15Graft-versus-host disease_Homo sapiens_hsa053321.97507950
16Autoimmune thyroid disease_Homo sapiens_hsa053201.96273318
17Phototransduction_Homo sapiens_hsa047441.95910726
18Type I diabetes mellitus_Homo sapiens_hsa049401.95073348
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89779126
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.87178185
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70860539
22Protein export_Homo sapiens_hsa030601.63314592
23Regulation of autophagy_Homo sapiens_hsa041401.43087418
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41089336
25RNA degradation_Homo sapiens_hsa030181.40804071
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35721956
27Fanconi anemia pathway_Homo sapiens_hsa034601.35140076
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33329209
29Peroxisome_Homo sapiens_hsa041461.29123662
30Caffeine metabolism_Homo sapiens_hsa002321.23748380
31Primary immunodeficiency_Homo sapiens_hsa053401.22684112
32Basal transcription factors_Homo sapiens_hsa030221.21791901
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18713192
34Homologous recombination_Homo sapiens_hsa034401.13757870
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13383204
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07125630
37Nicotine addiction_Homo sapiens_hsa050331.06752361
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04049886
39Pyrimidine metabolism_Homo sapiens_hsa002401.02846241
40Nitrogen metabolism_Homo sapiens_hsa009101.02435352
41Tryptophan metabolism_Homo sapiens_hsa003800.97838207
42Ether lipid metabolism_Homo sapiens_hsa005650.94869279
43Rheumatoid arthritis_Homo sapiens_hsa053230.93460804
44Purine metabolism_Homo sapiens_hsa002300.89522614
45Arachidonic acid metabolism_Homo sapiens_hsa005900.87331679
46Propanoate metabolism_Homo sapiens_hsa006400.83068940
47Retinol metabolism_Homo sapiens_hsa008300.79686955
48RNA transport_Homo sapiens_hsa030130.78370196
49Antigen processing and presentation_Homo sapiens_hsa046120.77976806
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77438182
51Olfactory transduction_Homo sapiens_hsa047400.76791949
52Sulfur relay system_Homo sapiens_hsa041220.75730586
53Fat digestion and absorption_Homo sapiens_hsa049750.73026439
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68013920
55Collecting duct acid secretion_Homo sapiens_hsa049660.66560026
56Hematopoietic cell lineage_Homo sapiens_hsa046400.66503718
57Dorso-ventral axis formation_Homo sapiens_hsa043200.65712646
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.64275013
59Butanoate metabolism_Homo sapiens_hsa006500.63811563
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.63132011
61Taste transduction_Homo sapiens_hsa047420.62478356
62Chemical carcinogenesis_Homo sapiens_hsa052040.62145340
63Ovarian steroidogenesis_Homo sapiens_hsa049130.56672411
64Metabolic pathways_Homo sapiens_hsa011000.56628661
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55654497
66Systemic lupus erythematosus_Homo sapiens_hsa053220.55519860
67Serotonergic synapse_Homo sapiens_hsa047260.55496275
68Nucleotide excision repair_Homo sapiens_hsa034200.53576072
69Folate biosynthesis_Homo sapiens_hsa007900.53189307
70Morphine addiction_Homo sapiens_hsa050320.52375450
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52081279
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.49669257
73beta-Alanine metabolism_Homo sapiens_hsa004100.49358650
74Viral myocarditis_Homo sapiens_hsa054160.48229452
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47818099
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.46005153
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40438986
78Mismatch repair_Homo sapiens_hsa034300.39755605
79GABAergic synapse_Homo sapiens_hsa047270.38943974
80Salivary secretion_Homo sapiens_hsa049700.38911744
81Staphylococcus aureus infection_Homo sapiens_hsa051500.36357750
82Glycerolipid metabolism_Homo sapiens_hsa005610.34870680
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34620765
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33062326
85Glutamatergic synapse_Homo sapiens_hsa047240.32859240
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32605323
87Circadian entrainment_Homo sapiens_hsa047130.29889004
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29323573
89T cell receptor signaling pathway_Homo sapiens_hsa046600.27554204
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27317409
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27267044
92Spliceosome_Homo sapiens_hsa030400.26461647
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25834001
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24311276
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24204484
96Insulin secretion_Homo sapiens_hsa049110.23735818
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22434116
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21492340
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18395419
100Dopaminergic synapse_Homo sapiens_hsa047280.17885674

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