ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	8.72705875
2	ribosomal small subunit assembly (GO:0000028)	8.72388753
3	ribosomal small subunit biogenesis (GO:0042274)	8.63740931
4	viral transcription (GO:0019083)	8.58633065
5	translational termination (GO:0006415)	8.21123361
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.00910321
7	chaperone-mediated protein transport (GO:0072321)	6.93452503
8	cotranslational protein targeting to membrane (GO:0006613)	6.88763669
9	protein targeting to ER (GO:0045047)	6.84549032
10	translational elongation (GO:0006414)	6.79986903
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.58777065
12	protein localization to endoplasmic reticulum (GO:0070972)	6.43377619
13	viral life cycle (GO:0019058)	6.26245541
14	cellular protein complex disassembly (GO:0043624)	6.21254333
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.98675262
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.68188618
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.62363431
18	ATP synthesis coupled proton transport (GO:0015986)	5.62363431
19	translational initiation (GO:0006413)	5.50948420
20	protein neddylation (GO:0045116)	5.19666843
21	protein complex disassembly (GO:0043241)	5.17161607
22	translation (GO:0006412)	5.08429460
23	ribosomal large subunit biogenesis (GO:0042273)	5.00143724
24	macromolecular complex disassembly (GO:0032984)	4.92738588
25	ribonucleoprotein complex biogenesis (GO:0022613)	4.87144320
26	protein targeting to membrane (GO:0006612)	4.57210375
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.51249431
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.48832223
29	behavioral response to nicotine (GO:0035095)	4.44502809
30	cellular component biogenesis (GO:0044085)	4.43348560
31	respiratory electron transport chain (GO:0022904)	4.36001002
32	electron transport chain (GO:0022900)	4.28981021
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.27040938
34	NADH dehydrogenase complex assembly (GO:0010257)	4.27040938
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.27040938
36	proteasome assembly (GO:0043248)	4.22797187
37	protein complex biogenesis (GO:0070271)	4.15671220
38	DNA damage response, detection of DNA damage (GO:0042769)	4.14514940
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.09207525
40	DNA deamination (GO:0045006)	4.01886775
41	regulation of mitochondrial translation (GO:0070129)	3.92697191
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.92160312
43	rRNA processing (GO:0006364)	3.90805456
44	mRNA catabolic process (GO:0006402)	3.85163343
45	rRNA metabolic process (GO:0016072)	3.75594260
46	pseudouridine synthesis (GO:0001522)	3.74805875
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.71021304
48	ribosome biogenesis (GO:0042254)	3.58129208
49	ncRNA 3-end processing (GO:0043628)	3.56089797
50	RNA catabolic process (GO:0006401)	3.52521475
51	GTP biosynthetic process (GO:0006183)	3.51172486
52	ubiquinone biosynthetic process (GO:0006744)	3.44281186
53	peptidyl-histidine modification (GO:0018202)	3.37453760
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.28240454
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.26523077
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.23296626
57	ATP biosynthetic process (GO:0006754)	3.18739053
58	protein targeting to mitochondrion (GO:0006626)	3.17213363
59	protein-cofactor linkage (GO:0018065)	3.16536007
60	hydrogen ion transmembrane transport (GO:1902600)	3.15933252
61	UTP biosynthetic process (GO:0006228)	3.15127561
62	pyrimidine nucleotide catabolic process (GO:0006244)	3.14162257
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.13848822
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.13848822
65	ubiquinone metabolic process (GO:0006743)	3.09358876
66	establishment of protein localization to membrane (GO:0090150)	3.07563922
67	protein targeting (GO:0006605)	3.02130045
68	myoblast migration (GO:0051451)	2.96770063
69	nonmotile primary cilium assembly (GO:0035058)	2.96375521
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.95895432
71	establishment of protein localization to mitochondrion (GO:0072655)	2.93891848
72	chromatin remodeling at centromere (GO:0031055)	2.93812157
73	respiratory chain complex IV assembly (GO:0008535)	2.89841130
74	protein localization to mitochondrion (GO:0070585)	2.87979621
75	cell proliferation in forebrain (GO:0021846)	2.86910772
76	establishment of protein localization to organelle (GO:0072594)	2.79563748
77	cardiovascular system development (GO:0072358)	2.75786954
78	cytochrome complex assembly (GO:0017004)	2.74662038
79	quinone biosynthetic process (GO:1901663)	2.73629717
80	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.72766079
81	UTP metabolic process (GO:0046051)	2.70828098
82	ncRNA processing (GO:0034470)	2.70060199
83	proton transport (GO:0015992)	2.70026203
84	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.69889364
85	CTP metabolic process (GO:0046036)	2.69145394
86	CTP biosynthetic process (GO:0006241)	2.69145394
87	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.66878865
88	hydrogen transport (GO:0006818)	2.62617662
89	negative regulation of telomere maintenance (GO:0032205)	2.59128230
90	termination of RNA polymerase III transcription (GO:0006386)	2.58720977
91	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58720977
92	heart trabecula morphogenesis (GO:0061384)	2.58215922
93	CENP-A containing nucleosome assembly (GO:0034080)	2.57112455
94	spliceosomal complex assembly (GO:0000245)	2.55276497
95	guanosine-containing compound biosynthetic process (GO:1901070)	2.54463265
96	intracellular protein transmembrane import (GO:0044743)	2.53445074
97	embryonic body morphogenesis (GO:0010172)	2.52921925
98	nucleoside triphosphate biosynthetic process (GO:0009142)	2.52867991
99	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.50379741
100	substrate-independent telencephalic tangential migration (GO:0021826)	2.50379741

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.88920647
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.31382690
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.08930956
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94545449
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42768032
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.21961923
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14217893
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06580600
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00961522
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.81462870
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.55102810
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.48504398
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37960640
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.37519579
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30917961
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.14875424
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13595276
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.11462591
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.09699483
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00062573
21	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.87504713
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.86503054
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84183239
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.82473500
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.75714087
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69024056
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65376210
28	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.62787343
29	VDR_22108803_ChIP-Seq_LS180_Human	1.60076079
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.58840136
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.56203454
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.55945193
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.54220079
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53044860
35	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.51907555
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51815598
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.49230615
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.48899882
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47660094
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46536886
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.45030270
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.43556339
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.42491020
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42317416
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41513458
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41198056
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.38858648
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36242990
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28970087
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28933758
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28239707
52	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.27916378
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26370190
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25368187
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24554682
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22226313
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.20695260
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.20465337
59	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.16151874
60	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.14782273
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13895019
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11584819
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10670165
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09059660
65	CTCF_20526341_ChIP-Seq_ESCs_Human	1.08837383
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.04720763
67	NCOR_22424771_ChIP-Seq_293T_Human	1.04663244
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02974606
69	ERA_21632823_ChIP-Seq_H3396_Human	1.02456542
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00517074
71	KDM5A_27292631_Chip-Seq_BREAST_Human	1.00479630
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99158967
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98631628
74	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.97350393
75	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.97175345
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96305233
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95629882
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95581937
79	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95488480
80	FUS_26573619_Chip-Seq_HEK293_Human	0.94816776
81	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92251196
82	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91526120
83	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.91518548
84	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.91076659
85	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.91076659
86	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.91051343
87	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89457168
88	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.89297574
89	EWS_26573619_Chip-Seq_HEK293_Human	0.89192472
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.89000946
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88791562
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88677340
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.87604851
94	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.87072622
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86946575
96	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.85359420
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.84474686
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.83774236
99	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.83600020
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.83168447

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.26679707
2	MP0006292_abnormal_olfactory_placode	4.28076404
3	MP0002163_abnormal_gland_morphology	3.79887118
4	MP0004145_abnormal_muscle_electrophysio	2.75073015
5	MP0003646_muscle_fatigue	2.45111819
6	MP0005646_abnormal_pituitary_gland	2.34210493
7	MP0004142_abnormal_muscle_tone	2.31074043
8	MP0002876_abnormal_thyroid_physiology	2.31061715
9	MP0005379_endocrine/exocrine_gland_phen	2.25270034
10	MP0002102_abnormal_ear_morphology	2.16636213
11	MP0001346_abnormal_lacrimal_gland	1.86844391
12	MP0006072_abnormal_retinal_apoptosis	1.80672446
13	MP0002160_abnormal_reproductive_system	1.77242443
14	MP0001440_abnormal_grooming_behavior	1.76418552
15	MP0005671_abnormal_response_to	1.71883785
16	MP0002095_abnormal_skin_pigmentation	1.69708219
17	MP0003567_abnormal_fetal_cardiomyocyte	1.68451789
18	MP0002837_dystrophic_cardiac_calcinosis	1.61386838
19	MP0003938_abnormal_ear_development	1.54152650
20	MP0008789_abnormal_olfactory_epithelium	1.53909576
21	MP0002653_abnormal_ependyma_morphology	1.52170414
22	MP0001529_abnormal_vocalization	1.52111504
23	MP0001293_anophthalmia	1.51792865
24	MP0003122_maternal_imprinting	1.51164752
25	MP0004885_abnormal_endolymph	1.50610922
26	MP0006036_abnormal_mitochondrial_physio	1.50281270
27	MP0000049_abnormal_middle_ear	1.49448225
28	MP0003186_abnormal_redox_activity	1.47612199
29	MP0005083_abnormal_biliary_tract	1.38814204
30	MP0008872_abnormal_physiological_respon	1.37547030
31	MP0001968_abnormal_touch/_nociception	1.37473931
32	MP0005551_abnormal_eye_electrophysiolog	1.35065831
33	MP0001905_abnormal_dopamine_level	1.34859422
34	MP0002277_abnormal_respiratory_mucosa	1.30710185
35	MP0010030_abnormal_orbit_morphology	1.28223164
36	MP0005389_reproductive_system_phenotype	1.27316104
37	MP0005670_abnormal_white_adipose	1.26562111
38	MP0001986_abnormal_taste_sensitivity	1.21845746
39	MP0002733_abnormal_thermal_nociception	1.20862884
40	MP0002272_abnormal_nervous_system	1.19461040
41	MP0005195_abnormal_posterior_eye	1.18396847
42	MP0003786_premature_aging	1.16798556
43	MP0009046_muscle_twitch	1.13987877
44	MP0003693_abnormal_embryo_hatching	1.13970521
45	MP0006276_abnormal_autonomic_nervous	1.12452979
46	MP0003878_abnormal_ear_physiology	1.09682796
47	MP0005377_hearing/vestibular/ear_phenot	1.09682796
48	MP0009053_abnormal_anal_canal	1.08354704
49	MP0005084_abnormal_gallbladder_morpholo	1.08293025
50	MP0005499_abnormal_olfactory_system	1.08214870
51	MP0005394_taste/olfaction_phenotype	1.08214870
52	MP0002234_abnormal_pharynx_morphology	1.07711481
53	MP0009745_abnormal_behavioral_response	1.07380275
54	MP0002557_abnormal_social/conspecific_i	1.05158608
55	MP0008877_abnormal_DNA_methylation	1.05113064
56	MP0000778_abnormal_nervous_system	1.04848096
57	MP0002938_white_spotting	1.03830315
58	MP0000631_abnormal_neuroendocrine_gland	1.03676649
59	MP0009384_cardiac_valve_regurgitation	1.02960446
60	MP0003136_yellow_coat_color	1.02510604
61	MP0009250_abnormal_appendicular_skeleto	1.01813337
62	MP0001286_abnormal_eye_development	1.00230642
63	MP0009333_abnormal_splenocyte_physiolog	0.98828897
64	MP0005365_abnormal_bile_salt	0.98364236
65	MP0002736_abnormal_nociception_after	0.97820054
66	MP0001502_abnormal_circadian_rhythm	0.97764883
67	MP0005645_abnormal_hypothalamus_physiol	0.97756315
68	MP0004742_abnormal_vestibular_system	0.97068654
69	MP0005085_abnormal_gallbladder_physiolo	0.96936127
70	MP0001485_abnormal_pinna_reflex	0.95645581
71	MP0008995_early_reproductive_senescence	0.94347937
72	MP0001970_abnormal_pain_threshold	0.93586275
73	MP0000026_abnormal_inner_ear	0.93097559
74	MP0003183_abnormal_peptide_metabolism	0.92504932
75	MP0005360_urolithiasis	0.90911150
76	MP0000372_irregular_coat_pigmentation	0.90312190
77	MP0002233_abnormal_nose_morphology	0.90267813
78	MP0002752_abnormal_somatic_nervous	0.89974119
79	MP0002210_abnormal_sex_determination	0.89833623
80	MP0003880_abnormal_central_pattern	0.87707742
81	MP0005253_abnormal_eye_physiology	0.86772919
82	MP0008875_abnormal_xenobiotic_pharmacok	0.85966562
83	MP0005391_vision/eye_phenotype	0.85421901
84	MP0002138_abnormal_hepatobiliary_system	0.84256410
85	MP0000015_abnormal_ear_pigmentation	0.84024188
86	MP0001486_abnormal_startle_reflex	0.82944940
87	MP0001984_abnormal_olfaction	0.82426768
88	MP0002063_abnormal_learning/memory/cond	0.81614261
89	MP0002638_abnormal_pupillary_reflex	0.80648541
90	MP0006035_abnormal_mitochondrial_morpho	0.79541230
91	MP0002572_abnormal_emotion/affect_behav	0.77533659
92	MP0010094_abnormal_chromosome_stability	0.77023020
93	MP0002064_seizures	0.76836126
94	MP0003937_abnormal_limbs/digits/tail_de	0.75266734
95	MP0003942_abnormal_urinary_system	0.75025611
96	MP0000537_abnormal_urethra_morphology	0.74952008
97	MP0001663_abnormal_digestive_system	0.74551415
98	MP0004019_abnormal_vitamin_homeostasis	0.72222742
99	MP0003635_abnormal_synaptic_transmissio	0.69934149
100	MP0000955_abnormal_spinal_cord	0.69409582

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.28249712
2	Acute necrotizing encephalopathy (HP:0006965)	5.09434837
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.90559596
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.53875676
5	Macrocytic anemia (HP:0001972)	4.38820370
6	Acute encephalopathy (HP:0006846)	4.27712750
7	Progressive macrocephaly (HP:0004481)	4.01045037
8	Mitochondrial inheritance (HP:0001427)	3.79076121
9	3-Methylglutaconic aciduria (HP:0003535)	3.74965172
10	Abnormal number of erythroid precursors (HP:0012131)	3.73265956
11	Increased CSF lactate (HP:0002490)	3.66024911
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.50035708
13	Pallor (HP:0000980)	3.41578023
14	Cerebral edema (HP:0002181)	3.32923203
15	Myokymia (HP:0002411)	3.14986275
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.14479149
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.14479149
18	Pendular nystagmus (HP:0012043)	2.90410156
19	Hepatocellular necrosis (HP:0001404)	2.83310269
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.80621984
21	True hermaphroditism (HP:0010459)	2.79171897
22	Pancreatic fibrosis (HP:0100732)	2.79107325
23	Absent thumb (HP:0009777)	2.75664969
24	Abnormality of midbrain morphology (HP:0002418)	2.75067423
25	Molar tooth sign on MRI (HP:0002419)	2.75067423
26	Pancreatic cysts (HP:0001737)	2.72790171
27	Hepatic necrosis (HP:0002605)	2.71620858
28	Stenosis of the external auditory canal (HP:0000402)	2.70978953
29	Increased serum lactate (HP:0002151)	2.70315726
30	Increased serum pyruvate (HP:0003542)	2.59114788
31	Abnormality of alanine metabolism (HP:0010916)	2.51220085
32	Hyperalaninemia (HP:0003348)	2.51220085
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51220085
34	Optic disc pallor (HP:0000543)	2.47030334
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.45475520
36	Increased hepatocellular lipid droplets (HP:0006565)	2.44574106
37	Abnormality of the anterior horn cell (HP:0006802)	2.44326562
38	Degeneration of anterior horn cells (HP:0002398)	2.44326562
39	Leukodystrophy (HP:0002415)	2.39947049
40	Lipid accumulation in hepatocytes (HP:0006561)	2.34666037
41	Maternal diabetes (HP:0009800)	2.30314884
42	Renal Fanconi syndrome (HP:0001994)	2.26107656
43	Colon cancer (HP:0003003)	2.25509461
44	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.24624566
45	Hypoplasia of the radius (HP:0002984)	2.24309064
46	Lactic acidosis (HP:0003128)	2.20901837
47	Increased IgM level (HP:0003496)	2.17118383
48	Anencephaly (HP:0002323)	2.13870216
49	Hyperglycinemia (HP:0002154)	2.13434250
50	Increased intramyocellular lipid droplets (HP:0012240)	2.11376471
51	Septo-optic dysplasia (HP:0100842)	2.08940403
52	Lethargy (HP:0001254)	2.08827237
53	Abnormality of the renal collecting system (HP:0004742)	2.08823929
54	Oligodactyly (hands) (HP:0001180)	2.08689482
55	Nephronophthisis (HP:0000090)	2.08199357
56	Medial flaring of the eyebrow (HP:0010747)	2.07485735
57	Abnormality of the labia minora (HP:0012880)	2.06194766
58	Cleft eyelid (HP:0000625)	2.05217114
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03384170
60	Poor head control (HP:0002421)	2.02343689
61	Depressed nasal ridge (HP:0000457)	2.01888289
62	Rib fusion (HP:0000902)	2.01758223
63	Oligodactyly (HP:0012165)	1.99367909
64	Exertional dyspnea (HP:0002875)	1.98795993
65	Respiratory failure (HP:0002878)	1.97912713
66	Decreased central vision (HP:0007663)	1.96721914
67	Progressive microcephaly (HP:0000253)	1.96667553
68	Hyperthyroidism (HP:0000836)	1.95739037
69	Exercise intolerance (HP:0003546)	1.95656312
70	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.92815190
71	Ectopic kidney (HP:0000086)	1.91082464
72	Short tibia (HP:0005736)	1.88734199
73	Hypoplasia of the ulna (HP:0003022)	1.88298260
74	Absent/shortened dynein arms (HP:0200106)	1.86395847
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86395847
76	Abolished electroretinogram (ERG) (HP:0000550)	1.85200932
77	Abnormality of the renal medulla (HP:0100957)	1.84767945
78	Forearm undergrowth (HP:0009821)	1.84247493
79	Duplicated collecting system (HP:0000081)	1.83771164
80	Sclerocornea (HP:0000647)	1.82448884
81	Respiratory difficulties (HP:0002880)	1.80441773
82	Abnormality of renal resorption (HP:0011038)	1.80148454
83	Cystic liver disease (HP:0006706)	1.79867157
84	Congenital stationary night blindness (HP:0007642)	1.78552705
85	X-linked dominant inheritance (HP:0001423)	1.78438120
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78175762
87	Male pseudohermaphroditism (HP:0000037)	1.76957617
88	Cerebral hypomyelination (HP:0006808)	1.76494927
89	Poor suck (HP:0002033)	1.76354831
90	Limb dystonia (HP:0002451)	1.76244038
91	Sensory axonal neuropathy (HP:0003390)	1.75812844
92	Abnormality of glycolysis (HP:0004366)	1.75651188
93	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.75123343
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75057191
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.74094401
96	Increased muscle lipid content (HP:0009058)	1.73160345
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.72608197
98	Patent foramen ovale (HP:0001655)	1.72577554
99	Type II lissencephaly (HP:0007260)	1.72373904
100	Increased corneal curvature (HP:0100692)	1.72267527

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	4.22400968
2	WNK4	3.89152809
3	NME2	3.67987555
4	STK16	3.47217141
5	TLK1	3.44334607
6	BCKDK	2.73049286
7	PLK4	2.58347998
8	ADRBK2	2.45633354
9	BUB1	2.21035133
10	TIE1	2.10059230
11	GRK1	2.09035258
12	NEK1	2.01930149
13	PRKD3	1.89214857
14	CAMKK2	1.85468393
15	DYRK2	1.85220699
16	VRK2	1.65798162
17	PINK1	1.65344787
18	STK39	1.63205548
19	ZAK	1.61244256
20	NUAK1	1.57656107
21	PIK3CA	1.54542047
22	SRPK1	1.46596406
23	VRK1	1.43224735
24	BRSK1	1.30212336
25	CDK19	1.25971234
26	CCNB1	1.18755059
27	EPHA4	1.18412688
28	EPHB2	1.14745594
29	BCR	1.04507332
30	AURKB	1.01905489
31	LRRK2	1.00235886
32	PASK	0.99800152
33	WNK1	0.97840120
34	TXK	0.95469602
35	PLK3	0.94134682
36	ADRBK1	0.93470134
37	PRKCG	0.92981008
38	PLK2	0.92815045
39	DAPK3	0.90434678
40	AURKA	0.84041885
41	CAMK1	0.82923168
42	CAMKK1	0.81025372
43	ILK	0.80156185
44	CSNK2A2	0.78792292
45	PHKG2	0.77229452
46	PHKG1	0.77229452
47	PRKCQ	0.77166370
48	PIK3CG	0.75116716
49	INSRR	0.74660608
50	CSNK1E	0.74252655
51	PRKACA	0.74205074
52	CSNK2A1	0.69833603
53	GRK5	0.68108199
54	PIM1	0.66744535
55	TEC	0.66740100
56	ABL2	0.66646249
57	CDC7	0.63792018
58	DAPK1	0.60723640
59	CAMK2A	0.60644019
60	BMPR1B	0.59958591
61	IKBKB	0.59757553
62	WNK3	0.59314992
63	PLK1	0.59230939
64	MAP2K7	0.57939494
65	PRKCD	0.57733176
66	ATR	0.57022127
67	MAPK15	0.56883662
68	MAP3K9	0.56155444
69	STK11	0.52577434
70	RPS6KA6	0.49789578
71	MUSK	0.49766719
72	MAPK13	0.49003755
73	CDK4	0.48741052
74	RPS6KA5	0.48236468
75	OBSCN	0.47168333
76	MAP4K2	0.45874673
77	MARK1	0.45108278
78	CAMK2D	0.44727338
79	PRKCE	0.44386301
80	BRSK2	0.44126082
81	CHEK1	0.43857700
82	PRKG1	0.42920192
83	PRKCA	0.42705300
84	RIPK4	0.40937774
85	MINK1	0.39938797
86	NTRK1	0.38955947
87	MARK3	0.38888743
88	PAK3	0.38788545
89	MAP3K11	0.38698854
90	PRKCH	0.38185034
91	PIM2	0.37947733
92	TGFBR2	0.37751782
93	CAMK2B	0.37236824
94	EIF2AK1	0.36865706
95	DYRK1B	0.36386956
96	BMPR2	0.36372922
97	NTRK2	0.36003627
98	GRK6	0.35745992
99	CAMK2G	0.35361356
100	MAP2K6	0.34906217

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.48328569
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.31593919
3	Parkinsons disease_Homo sapiens_hsa05012	3.78541169
4	Sulfur relay system_Homo sapiens_hsa04122	2.59515496
5	One carbon pool by folate_Homo sapiens_hsa00670	2.55106951
6	Proteasome_Homo sapiens_hsa03050	2.54947369
7	Alzheimers disease_Homo sapiens_hsa05010	2.49800308
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.48186033
9	Huntingtons disease_Homo sapiens_hsa05016	2.47488169
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37442090
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.29139874
12	Protein export_Homo sapiens_hsa03060	1.92945111
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76534706
14	RNA polymerase_Homo sapiens_hsa03020	1.66309869
15	Homologous recombination_Homo sapiens_hsa03440	1.61886295
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57083456
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53243729
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51392206
19	Mismatch repair_Homo sapiens_hsa03430	1.41978408
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.40381293
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32935882
22	DNA replication_Homo sapiens_hsa03030	1.30617957
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27278731
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19701362
25	Asthma_Homo sapiens_hsa05310	1.15944721
26	Peroxisome_Homo sapiens_hsa04146	1.15927492
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14790352
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.12097661
29	Spliceosome_Homo sapiens_hsa03040	1.06572955
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.06122939
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04620804
32	Basal transcription factors_Homo sapiens_hsa03022	1.02688044
33	Folate biosynthesis_Homo sapiens_hsa00790	0.99873829
34	RNA degradation_Homo sapiens_hsa03018	0.98967811
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94816378
36	Pyruvate metabolism_Homo sapiens_hsa00620	0.94101213
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92425753
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.91845605
39	Retinol metabolism_Homo sapiens_hsa00830	0.88293940
40	Graft-versus-host disease_Homo sapiens_hsa05332	0.87698082
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86454989
42	Allograft rejection_Homo sapiens_hsa05330	0.86343998
43	RNA transport_Homo sapiens_hsa03013	0.85911385
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82962400
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.82714542
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.78423587
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75645178
48	Metabolic pathways_Homo sapiens_hsa01100	0.74530066
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73204659
50	Butanoate metabolism_Homo sapiens_hsa00650	0.72948321
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72902627
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72392885
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71447134
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.70044190
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69901241
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69813221
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69422322
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.68492008
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66811170
60	Nicotine addiction_Homo sapiens_hsa05033	0.65103655
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63445671
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62952832
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.62574032
64	Purine metabolism_Homo sapiens_hsa00230	0.61704663
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61556655
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59874298
67	Sulfur metabolism_Homo sapiens_hsa00920	0.55017167
68	Fatty acid degradation_Homo sapiens_hsa00071	0.54404278
69	Olfactory transduction_Homo sapiens_hsa04740	0.52901253
70	Phototransduction_Homo sapiens_hsa04744	0.51846236
71	Glutathione metabolism_Homo sapiens_hsa00480	0.50828051
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49810859
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49259087
74	Base excision repair_Homo sapiens_hsa03410	0.47436399
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45668021
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44971194
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44105479
78	Propanoate metabolism_Homo sapiens_hsa00640	0.43514490
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42996454
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42850448
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41437042
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.40306924
83	p53 signaling pathway_Homo sapiens_hsa04115	0.35330576
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.35288192
85	Caffeine metabolism_Homo sapiens_hsa00232	0.33935152
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33151835
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.32875704
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32003264
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31546796
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30759660
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29827496
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.29735280
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27924242
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.27880782
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27420764
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26235801
97	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25825598
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23320614
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23221522
100	Taste transduction_Homo sapiens_hsa04742	0.23004674

RPS7P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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