ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	8.94048865
2	ribosomal small subunit biogenesis (GO:0042274)	6.50165984
3	ATP synthesis coupled proton transport (GO:0015986)	6.38429061
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.38429061
5	viral transcription (GO:0019083)	6.15799765
6	nucleoside transmembrane transport (GO:1901642)	6.06627181
7	translational termination (GO:0006415)	5.86584594
8	GDP-mannose metabolic process (GO:0019673)	5.84616349
9	translational elongation (GO:0006414)	5.31350069
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.08649083
11	protein targeting to ER (GO:0045047)	5.02604634
12	cotranslational protein targeting to membrane (GO:0006613)	5.00702107
13	DNA deamination (GO:0045006)	4.90550196
14	protein localization to endoplasmic reticulum (GO:0070972)	4.75173288
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.73674289
16	mannose metabolic process (GO:0006013)	4.68921404
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68372872
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.58937183
19	protein complex biogenesis (GO:0070271)	4.54997806
20	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.49162976
21	viral life cycle (GO:0019058)	4.46698277
22	cellular protein complex disassembly (GO:0043624)	4.37905396
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.36343204
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.36343204
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.33725740
26	nucleoside transport (GO:0015858)	4.33599159
27	ribosomal small subunit assembly (GO:0000028)	4.27529628
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.20887139
29	monoubiquitinated protein deubiquitination (GO:0035520)	4.19451763
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.17707559
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.17707559
32	NADH dehydrogenase complex assembly (GO:0010257)	4.17707559
33	ribosomal large subunit biogenesis (GO:0042273)	4.08035718
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.03234497
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95991822
36	cellular component biogenesis (GO:0044085)	3.94132334
37	maturation of SSU-rRNA (GO:0030490)	3.93516085
38	translational initiation (GO:0006413)	3.91911736
39	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.85020549
40	cytochrome complex assembly (GO:0017004)	3.75327040
41	translation (GO:0006412)	3.66852436
42	protein complex disassembly (GO:0043241)	3.64437204
43	ATP biosynthetic process (GO:0006754)	3.63223007
44	protein targeting to membrane (GO:0006612)	3.60330765
45	electron transport chain (GO:0022900)	3.59020578
46	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.58076097
47	respiratory electron transport chain (GO:0022904)	3.56748424
48	response to pheromone (GO:0019236)	3.56684116
49	water-soluble vitamin biosynthetic process (GO:0042364)	3.55192182
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.55155949
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.54233886
52	macromolecular complex disassembly (GO:0032984)	3.45169256
53	ribonucleoprotein complex biogenesis (GO:0022613)	3.43357957
54	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.39772010
55	protein deneddylation (GO:0000338)	3.26744015
56	GTP biosynthetic process (GO:0006183)	3.25768339
57	respiratory chain complex IV assembly (GO:0008535)	3.23058219
58	mRNA catabolic process (GO:0006402)	3.15555097
59	modified amino acid transport (GO:0072337)	3.11161314
60	intracellular protein transmembrane import (GO:0044743)	3.07828606
61	interferon-gamma production (GO:0032609)	3.06760809
62	behavioral response to nicotine (GO:0035095)	3.05408774
63	sulfur compound transport (GO:0072348)	3.02132104
64	positive regulation of T cell apoptotic process (GO:0070234)	2.98722261
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.93963481
66	negative regulation of cAMP-mediated signaling (GO:0043951)	2.92425214
67	pantothenate metabolic process (GO:0015939)	2.91050111
68	positive regulation of fatty acid transport (GO:2000193)	2.89242775
69	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.88414978
70	positive regulation of icosanoid secretion (GO:0032305)	2.88336829
71	cofactor transport (GO:0051181)	2.86863530
72	coenzyme A biosynthetic process (GO:0015937)	2.81930438
73	RNA catabolic process (GO:0006401)	2.79842382
74	hydrogen ion transmembrane transport (GO:1902600)	2.75858610
75	cell proliferation in forebrain (GO:0021846)	2.74701270
76	regulation of mitochondrial membrane potential (GO:0051881)	2.73679433
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.71210029
78	prenylation (GO:0097354)	2.70629661
79	protein prenylation (GO:0018342)	2.70629661
80	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.66665417
81	negative regulation of execution phase of apoptosis (GO:1900118)	2.66291815
82	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.64860348
83	indolalkylamine metabolic process (GO:0006586)	2.64834664
84	UTP biosynthetic process (GO:0006228)	2.63761251
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.62794988
86	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.61651740
87	limb bud formation (GO:0060174)	2.61210159
88	nucleoside triphosphate biosynthetic process (GO:0009142)	2.59173712
89	tongue development (GO:0043586)	2.58783858
90	rhodopsin mediated signaling pathway (GO:0016056)	2.58495193
91	proton transport (GO:0015992)	2.55482269
92	peroxisome fission (GO:0016559)	2.53293319
93	guanosine-containing compound biosynthetic process (GO:1901070)	2.53082546
94	deoxyribonucleotide catabolic process (GO:0009264)	2.52570008
95	oxidative demethylation (GO:0070989)	2.52199300
96	glycerophospholipid catabolic process (GO:0046475)	2.51323724
97	hydrogen transport (GO:0006818)	2.50559493
98	short-chain fatty acid metabolic process (GO:0046459)	2.49879675
99	indolalkylamine catabolic process (GO:0046218)	2.48700635
100	tryptophan catabolic process (GO:0006569)	2.48700635

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.63575875
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.60902162
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.13664989
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.91141911
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.71655654
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.46884628
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.41206365
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95647675
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.91586170
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66581806
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.58281246
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.47770204
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44079944
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43542016
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29501882
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06488524
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98366678
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.84755265
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.74356856
20	VDR_22108803_ChIP-Seq_LS180_Human	1.66775123
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60496366
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57741692
23	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.54454631
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53547496
25	EWS_26573619_Chip-Seq_HEK293_Human	1.52975840
26	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52329672
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51424159
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47906259
29	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.46457055
30	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.46425974
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42272017
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.41280233
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41168225
34	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.39526010
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.39118881
36	FUS_26573619_Chip-Seq_HEK293_Human	1.33288293
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33252555
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.33222977
39	PHF8_20622853_ChIP-Seq_HELA_Human	1.30441576
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29211827
41	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.28591704
42	RBPJ_21746931_ChIP-Seq_IB4_Human	1.25258446
43	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24505841
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21220446
45	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20956115
46	NCOR_22424771_ChIP-Seq_293T_Human	1.20314260
47	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.19896759
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.18321159
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17046010
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17046010
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16446933
52	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13903187
53	AR_20517297_ChIP-Seq_VCAP_Human	1.13685356
54	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.13623245
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.13456616
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.11554630
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11554630
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10381857
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10375657
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09119378
61	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.08051234
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06476574
63	E2F1_20622854_ChIP-Seq_HELA_Human	1.06430058
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06172168
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.05733183
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05440099
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05440099
68	P300_19829295_ChIP-Seq_ESCs_Human	1.04428113
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04030313
70	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03046810
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02884871
72	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.02221606
73	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.01971432
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00745942
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00698652
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00579353
77	IGF1R_20145208_ChIP-Seq_DFB_Human	1.00553695
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98668731
79	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98160250
80	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97638657
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97561387
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.97512354
83	NFYA_21822215_ChIP-Seq_K562_Human	0.96529308
84	NFYB_21822215_ChIP-Seq_K562_Human	0.96348074
85	KDM5A_27292631_Chip-Seq_BREAST_Human	0.95793784
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94875667
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.94544278
88	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.94406686
89	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94240881
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.93879600
91	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.93231840
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93049685
93	XRN2_22483619_ChIP-Seq_HELA_Human	0.91926870
94	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91561059
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.91214784
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90951860
97	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.89611507
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.89578148
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89332518
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87986177

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.67474906
2	MP0009379_abnormal_foot_pigmentation	4.24623187
3	MP0006292_abnormal_olfactory_placode	3.74862749
4	MP0002638_abnormal_pupillary_reflex	3.65799012
5	MP0001529_abnormal_vocalization	3.30969487
6	MP0008875_abnormal_xenobiotic_pharmacok	3.06388470
7	MP0006072_abnormal_retinal_apoptosis	2.99592570
8	MP0005671_abnormal_response_to	2.31047848
9	MP0002837_dystrophic_cardiac_calcinosis	2.28263771
10	MP0002653_abnormal_ependyma_morphology	2.27167405
11	MP0008789_abnormal_olfactory_epithelium	2.19353375
12	MP0003880_abnormal_central_pattern	2.05624310
13	MP0004133_heterotaxia	1.96124004
14	MP0002234_abnormal_pharynx_morphology	1.89963974
15	MP0001293_anophthalmia	1.87768727
16	MP0002102_abnormal_ear_morphology	1.84853273
17	MP0002736_abnormal_nociception_after	1.80458191
18	MP0004043_abnormal_pH_regulation	1.61399299
19	MP0008872_abnormal_physiological_respon	1.60961162
20	MP0005646_abnormal_pituitary_gland	1.53763481
21	MP0005085_abnormal_gallbladder_physiolo	1.52828845
22	MP0005499_abnormal_olfactory_system	1.51516380
23	MP0005394_taste/olfaction_phenotype	1.51516380
24	MP0001968_abnormal_touch/_nociception	1.51390185
25	MP0000778_abnormal_nervous_system	1.46720662
26	MP0005645_abnormal_hypothalamus_physiol	1.45605706
27	MP0000372_irregular_coat_pigmentation	1.45578780
28	MP0005389_reproductive_system_phenotype	1.43200023
29	MP0001542_abnormal_bone_strength	1.42800002
30	MP0002163_abnormal_gland_morphology	1.41409111
31	MP0003806_abnormal_nucleotide_metabolis	1.38640006
32	MP0005195_abnormal_posterior_eye	1.36120242
33	MP0000049_abnormal_middle_ear	1.33876083
34	MP0003787_abnormal_imprinting	1.33432952
35	MP0002160_abnormal_reproductive_system	1.31528081
36	MP0002938_white_spotting	1.31074701
37	MP0005084_abnormal_gallbladder_morpholo	1.31032898
38	MP0005551_abnormal_eye_electrophysiolog	1.27711876
39	MP0003136_yellow_coat_color	1.25145426
40	MP0005377_hearing/vestibular/ear_phenot	1.22723082
41	MP0003878_abnormal_ear_physiology	1.22723082
42	MP0000631_abnormal_neuroendocrine_gland	1.18298999
43	MP0003890_abnormal_embryonic-extraembry	1.18212600
44	MP0005253_abnormal_eye_physiology	1.16078932
45	MP0004142_abnormal_muscle_tone	1.15731603
46	MP0001485_abnormal_pinna_reflex	1.14084007
47	MP0004885_abnormal_endolymph	1.11459192
48	MP0008877_abnormal_DNA_methylation	1.09469507
49	MP0009250_abnormal_appendicular_skeleto	1.08447267
50	MP0001919_abnormal_reproductive_system	1.05987962
51	MP0004147_increased_porphyrin_level	1.05648552
52	MP0003693_abnormal_embryo_hatching	1.04360241
53	MP0003567_abnormal_fetal_cardiomyocyte	1.03909492
54	MP0003186_abnormal_redox_activity	1.02379632
55	MP0005332_abnormal_amino_acid	1.00334161
56	MP0000678_abnormal_parathyroid_gland	0.99767844
57	MP0001970_abnormal_pain_threshold	0.99333508
58	MP0003937_abnormal_limbs/digits/tail_de	0.98904792
59	MP0003252_abnormal_bile_duct	0.98164498
60	MP0003122_maternal_imprinting	0.97849854
61	MP0002557_abnormal_social/conspecific_i	0.97003631
62	MP0002735_abnormal_chemical_nociception	0.94750635
63	MP0003195_calcinosis	0.92030454
64	MP0009764_decreased_sensitivity_to	0.91996486
65	MP0001501_abnormal_sleep_pattern	0.91862245
66	MP0008775_abnormal_heart_ventricle	0.91739207
67	MP0002733_abnormal_thermal_nociception	0.91287860
68	MP0002210_abnormal_sex_determination	0.89906387
69	MP0002752_abnormal_somatic_nervous	0.88191861
70	MP0005391_vision/eye_phenotype	0.85743832
71	MP0002184_abnormal_innervation	0.84793063
72	MP0001905_abnormal_dopamine_level	0.80246601
73	MP0002572_abnormal_emotion/affect_behav	0.77082310
74	MP0000647_abnormal_sebaceous_gland	0.76797506
75	MP0002734_abnormal_mechanical_nocicepti	0.76666061
76	MP0004924_abnormal_behavior	0.76529971
77	MP0005386_behavior/neurological_phenoty	0.76529971
78	MP0003011_delayed_dark_adaptation	0.76357008
79	MP0001929_abnormal_gametogenesis	0.75231767
80	MP0000653_abnormal_sex_gland	0.74742293
81	MP0002233_abnormal_nose_morphology	0.74731108
82	MP0001145_abnormal_male_reproductive	0.74579541
83	MP0009053_abnormal_anal_canal	0.74330322
84	MP0002249_abnormal_larynx_morphology	0.74110720
85	MP0009333_abnormal_splenocyte_physiolog	0.73572325
86	MP0002272_abnormal_nervous_system	0.73131699
87	MP0001286_abnormal_eye_development	0.72886700
88	MP0009745_abnormal_behavioral_response	0.71202347
89	MP0005408_hypopigmentation	0.70225837
90	MP0001119_abnormal_female_reproductive	0.69396147
91	MP0006036_abnormal_mitochondrial_physio	0.69251870
92	MP0003698_abnormal_male_reproductive	0.68443319
93	MP0005448_abnormal_energy_balance	0.68249136
94	MP0003755_abnormal_palate_morphology	0.67446516
95	MP0002095_abnormal_skin_pigmentation	0.67387147
96	MP0005360_urolithiasis	0.66883573
97	MP0003936_abnormal_reproductive_system	0.64996252
98	MP0000026_abnormal_inner_ear	0.64887734
99	MP0001764_abnormal_homeostasis	0.64819265
100	MP0000955_abnormal_spinal_cord	0.63588278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	5.27828899
2	Acute necrotizing encephalopathy (HP:0006965)	4.36328603
3	Mitochondrial inheritance (HP:0001427)	4.20320261
4	Hepatocellular necrosis (HP:0001404)	4.17304654
5	Hypobetalipoproteinemia (HP:0003563)	4.15906732
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.92915683
7	3-Methylglutaconic aciduria (HP:0003535)	3.88170467
8	Increased CSF lactate (HP:0002490)	3.85280477
9	Progressive macrocephaly (HP:0004481)	3.71041316
10	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.59624311
11	Hepatic necrosis (HP:0002605)	3.56857619
12	Acute encephalopathy (HP:0006846)	3.52665937
13	Hypoplasia of the pons (HP:0012110)	3.45827961
14	Abnormality of the pons (HP:0007361)	3.21532613
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.20522850
16	Reticulocytopenia (HP:0001896)	3.09627743
17	Increased hepatocellular lipid droplets (HP:0006565)	3.03304808
18	Congenital stationary night blindness (HP:0007642)	3.01645242
19	Patent foramen ovale (HP:0001655)	2.96241618
20	Dyskinesia (HP:0100660)	2.91919972
21	Hyperglycinemia (HP:0002154)	2.80975294
22	Neurodegeneration (HP:0002180)	2.80193838
23	Lipid accumulation in hepatocytes (HP:0006561)	2.79352879
24	Increased serum lactate (HP:0002151)	2.76317846
25	Methylmalonic acidemia (HP:0002912)	2.72270112
26	Macrocytic anemia (HP:0001972)	2.68453660
27	Cerebral edema (HP:0002181)	2.63077508
28	Type II lissencephaly (HP:0007260)	2.62916248
29	Acanthocytosis (HP:0001927)	2.62308928
30	Microretrognathia (HP:0000308)	2.58701172
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.53211145
32	CNS demyelination (HP:0007305)	2.52539243
33	Dysphonia (HP:0001618)	2.52287799
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.49865790
35	Renal Fanconi syndrome (HP:0001994)	2.49134271
36	Pallor (HP:0000980)	2.39884242
37	Abnormality of alanine metabolism (HP:0010916)	2.37450323
38	Hyperalaninemia (HP:0003348)	2.37450323
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.37450323
40	Lactic acidosis (HP:0003128)	2.35407567
41	Tubulointerstitial nephritis (HP:0001970)	2.35096913
42	Impulsivity (HP:0100710)	2.34313004
43	Delayed epiphyseal ossification (HP:0002663)	2.33150860
44	Methylmalonic aciduria (HP:0012120)	2.29642209
45	Ketoacidosis (HP:0001993)	2.28845111
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.26636441
47	Exertional dyspnea (HP:0002875)	2.26620400
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25578813
49	Akinesia (HP:0002304)	2.24177906
50	Hypoproteinemia (HP:0003075)	2.21661017
51	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.19976160
52	Septo-optic dysplasia (HP:0100842)	2.18261460
53	Congenital, generalized hypertrichosis (HP:0004540)	2.15930191
54	Opisthotonus (HP:0002179)	2.15468263
55	Leukodystrophy (HP:0002415)	2.15224343
56	Cerebellar dysplasia (HP:0007033)	2.14855486
57	Hypoplasia of the uterus (HP:0000013)	2.13283105
58	Pancreatic fibrosis (HP:0100732)	2.12139378
59	True hermaphroditism (HP:0010459)	2.11481843
60	Abnormal number of erythroid precursors (HP:0012131)	2.10114884
61	Abnormality of midbrain morphology (HP:0002418)	2.09599124
62	Molar tooth sign on MRI (HP:0002419)	2.09599124
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07999787
64	Medial flaring of the eyebrow (HP:0010747)	2.06697835
65	Increased intramyocellular lipid droplets (HP:0012240)	2.06599910
66	Absent thumb (HP:0009777)	2.06456979
67	Short femoral neck (HP:0100864)	2.06151682
68	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05621870
69	Respiratory failure (HP:0002878)	2.05496447
70	Abnormality of the 2nd finger (HP:0004100)	2.05068666
71	Elevated erythrocyte sedimentation rate (HP:0003565)	2.01707727
72	Agitation (HP:0000713)	1.99332677
73	Stenosis of the external auditory canal (HP:0000402)	1.96134888
74	Restlessness (HP:0000711)	1.94229495
75	Nephronophthisis (HP:0000090)	1.93148054
76	Abnormality of renal resorption (HP:0011038)	1.90896246
77	Generalized aminoaciduria (HP:0002909)	1.90498986
78	11 pairs of ribs (HP:0000878)	1.90360532
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.89413715
80	Abnormality of glycine metabolism (HP:0010895)	1.89413715
81	Abnormality of the middle phalanges of the toes (HP:0010183)	1.89369738
82	Optic disc pallor (HP:0000543)	1.88472471
83	Pancreatic cysts (HP:0001737)	1.88342481
84	Hypoplasia of the ulna (HP:0003022)	1.88206896
85	Poor suck (HP:0002033)	1.87715185
86	Abnormality of serum amino acid levels (HP:0003112)	1.86714274
87	Craniofacial dystonia (HP:0012179)	1.85519738
88	Respiratory difficulties (HP:0002880)	1.85347214
89	Irregular epiphyses (HP:0010582)	1.84993978
90	Diminished movement (HP:0002374)	1.84207527
91	Focal dystonia (HP:0004373)	1.83401960
92	Partial duplication of the phalanx of hand (HP:0009999)	1.83013830
93	Type I transferrin isoform profile (HP:0003642)	1.80432622
94	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79235237
95	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79235237
96	Brushfield spots (HP:0001088)	1.78695627
97	Ketosis (HP:0001946)	1.78471615
98	Abnormality of DNA repair (HP:0003254)	1.76639497
99	Abolished electroretinogram (ERG) (HP:0000550)	1.75903420
100	Hypolipoproteinemia (HP:0010981)	1.74452992

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	3.71055122
2	TIE1	3.51571572
3	TAOK3	3.27313804
4	TLK1	2.93244392
5	NUAK1	2.61128794
6	ZAK	2.46308872
7	WNK4	2.45636386
8	CDK19	2.33174422
9	FRK	2.30195125
10	ERN1	2.26395728
11	GRK1	2.24215676
12	TNIK	2.11691367
13	PDK2	1.93394868
14	VRK1	1.87719456
15	PIK3CA	1.77994449
16	TAOK1	1.69022652
17	OXSR1	1.67799693
18	INSRR	1.66986303
19	VRK2	1.60589368
20	PASK	1.55950845
21	ADRBK2	1.53450242
22	MAP4K2	1.46522357
23	MARK3	1.45752501
24	STK39	1.35091720
25	BMPR1B	1.33353094
26	MAP4K1	1.31968484
27	KDR	1.25784914
28	DYRK2	1.24998512
29	MAPK15	1.24257245
30	BCKDK	1.16624036
31	MST4	1.16463063
32	PLK2	1.15940447
33	CAMK1D	1.12835867
34	PINK1	1.04634686
35	STK16	1.02179785
36	MAPK13	1.02134591
37	MAP2K6	0.99843136
38	NME2	0.97953572
39	SRPK1	0.92998131
40	NME1	0.92501623
41	AURKA	0.85634992
42	NTRK2	0.85152692
43	WNK3	0.83881948
44	TGFBR1	0.82435854
45	MAP3K12	0.80446675
46	PHKG2	0.79869491
47	PHKG1	0.79869491
48	PLK3	0.78668495
49	MINK1	0.77594722
50	ADRBK1	0.75787186
51	TEC	0.75626728
52	DAPK3	0.73764086
53	PRKCG	0.72550759
54	GRK5	0.70056657
55	STK38	0.69876069
56	STK11	0.69605063
57	RIPK1	0.68911236
58	BMPR2	0.68574019
59	GRK7	0.66697567
60	LCK	0.66320459
61	BUB1	0.64650204
62	OBSCN	0.62766968
63	PRKCQ	0.62683576
64	CAMKK2	0.61253742
65	MAP3K4	0.60906135
66	AKT2	0.60370565
67	PKN1	0.60117294
68	CAMK1G	0.57424136
69	CDK8	0.57276705
70	CCNB1	0.55722208
71	RPS6KA5	0.54669983
72	PIK3CG	0.53036034
73	NEK1	0.52842359
74	PRKCI	0.50318276
75	DAPK2	0.48131400
76	RPS6KB1	0.46798445
77	CSF1R	0.46414090
78	EPHB2	0.45831170
79	CSNK1A1	0.45349776
80	PRKCD	0.44646454
81	ATR	0.44307488
82	PRKCA	0.44240594
83	IKBKB	0.43794708
84	PRKACA	0.43558424
85	NEK2	0.43352788
86	CSNK2A2	0.43048723
87	CAMK1	0.42318883
88	RPS6KB2	0.41583250
89	AURKB	0.40589955
90	CSNK2A1	0.40014554
91	PLK1	0.39411652
92	CDC7	0.39390764
93	PIM1	0.39119091
94	LRRK2	0.39004734
95	CAMK2A	0.36836204
96	ATM	0.36231728
97	PDK1	0.36185321
98	IKBKE	0.35279342
99	EIF2AK1	0.34024867
100	STK3	0.33754497

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.40488174
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.74099748
3	Parkinsons disease_Homo sapiens_hsa05012	3.13791499
4	Caffeine metabolism_Homo sapiens_hsa00232	2.91362637
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.76984730
6	Asthma_Homo sapiens_hsa05310	2.73624518
7	Phototransduction_Homo sapiens_hsa04744	2.41102064
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.25194396
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22602196
10	Alzheimers disease_Homo sapiens_hsa05010	2.12494322
11	Proteasome_Homo sapiens_hsa03050	2.09712917
12	One carbon pool by folate_Homo sapiens_hsa00670	2.09502623
13	Huntingtons disease_Homo sapiens_hsa05016	2.01275026
14	Allograft rejection_Homo sapiens_hsa05330	2.00988937
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89560573
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.89507781
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.86744424
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78129957
19	Sulfur metabolism_Homo sapiens_hsa00920	1.72427166
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66737012
21	RNA polymerase_Homo sapiens_hsa03020	1.66409252
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.64591830
23	RNA degradation_Homo sapiens_hsa03018	1.62226138
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.60313161
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.52879572
26	Protein export_Homo sapiens_hsa03060	1.50025705
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.42133479
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.37040968
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.31445859
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28581801
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.28364426
32	Sulfur relay system_Homo sapiens_hsa04122	1.26023633
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22704737
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15940501
35	Propanoate metabolism_Homo sapiens_hsa00640	1.15287972
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03133786
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99889975
38	Ether lipid metabolism_Homo sapiens_hsa00565	0.99851842
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.96006699
40	Steroid biosynthesis_Homo sapiens_hsa00100	0.86691886
41	Purine metabolism_Homo sapiens_hsa00230	0.85071427
42	Butanoate metabolism_Homo sapiens_hsa00650	0.84534745
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83990663
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78742166
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76762428
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76640897
47	Peroxisome_Homo sapiens_hsa04146	0.75590189
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74931799
49	Metabolic pathways_Homo sapiens_hsa01100	0.73965145
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.71527346
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71516992
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69995301
53	Basal transcription factors_Homo sapiens_hsa03022	0.69381527
54	Regulation of autophagy_Homo sapiens_hsa04140	0.67994026
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65770829
56	Viral myocarditis_Homo sapiens_hsa05416	0.64948759
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63993143
58	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.61461814
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60961270
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60886991
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60270071
62	Olfactory transduction_Homo sapiens_hsa04740	0.58974788
63	Glutathione metabolism_Homo sapiens_hsa00480	0.58339102
64	Mismatch repair_Homo sapiens_hsa03430	0.54794621
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.51884643
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51301943
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.50837030
68	Retinol metabolism_Homo sapiens_hsa00830	0.50536741
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49644430
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48471904
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48183798
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.48103741
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44143819
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43316490
75	DNA replication_Homo sapiens_hsa03030	0.42744183
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42678695
77	Base excision repair_Homo sapiens_hsa03410	0.42301533
78	Spliceosome_Homo sapiens_hsa03040	0.42236561
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42232089
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41460386
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41215425
82	Fatty acid degradation_Homo sapiens_hsa00071	0.40792166
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39069659
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38861548
85	Homologous recombination_Homo sapiens_hsa03440	0.37874048
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.37789706
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.37064493
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36864973
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.36403097
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35852429
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31506974
92	Alcoholism_Homo sapiens_hsa05034	0.30745872
93	Nicotine addiction_Homo sapiens_hsa05033	0.30152902
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29336099
95	RNA transport_Homo sapiens_hsa03013	0.27652464
96	Serotonergic synapse_Homo sapiens_hsa04726	0.25827979
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22398103
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21629264
99	Taste transduction_Homo sapiens_hsa04742	0.21233945
100	Morphine addiction_Homo sapiens_hsa05032	0.20629907

RPS7P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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