ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.64914933
2	viral transcription (GO:0019083)	8.57843516
3	chaperone-mediated protein transport (GO:0072321)	8.52752670
4	translational termination (GO:0006415)	8.18843642
5	ribosomal small subunit assembly (GO:0000028)	8.00770088
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.97767759
7	translational elongation (GO:0006414)	6.92693222
8	cotranslational protein targeting to membrane (GO:0006613)	6.89368107
9	protein targeting to ER (GO:0045047)	6.83504675
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.52314885
11	protein localization to endoplasmic reticulum (GO:0070972)	6.44253913
12	cellular protein complex disassembly (GO:0043624)	6.19150391
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.16221341
14	ATP synthesis coupled proton transport (GO:0015986)	6.16221341
15	viral life cycle (GO:0019058)	5.99276718
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.81545878
17	maturation of SSU-rRNA (GO:0030490)	5.68376885
18	translational initiation (GO:0006413)	5.20731260
19	protein complex disassembly (GO:0043241)	5.12335171
20	macromolecular complex disassembly (GO:0032984)	4.75939946
21	protein targeting to membrane (GO:0006612)	4.73747250
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.66421451
23	ribosomal large subunit biogenesis (GO:0042273)	4.59627692
24	behavioral response to nicotine (GO:0035095)	4.54956798
25	translation (GO:0006412)	4.45570843
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21963213
27	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.14101630
28	ribonucleoprotein complex biogenesis (GO:0022613)	4.13728715
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.09427551
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.09427551
31	cellular component biogenesis (GO:0044085)	4.04325032
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00518004
33	respiratory electron transport chain (GO:0022904)	3.92011490
34	mRNA catabolic process (GO:0006402)	3.89188597
35	electron transport chain (GO:0022900)	3.86685924
36	protein neddylation (GO:0045116)	3.77885254
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.72454170
38	response to misfolded protein (GO:0051788)	3.67610892
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.67438046
40	ATP biosynthetic process (GO:0006754)	3.64886812
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.59564957
42	DNA deamination (GO:0045006)	3.58813987
43	cell proliferation in forebrain (GO:0021846)	3.58609055
44	RNA catabolic process (GO:0006401)	3.50595383
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.48922056
46	protein complex biogenesis (GO:0070271)	3.48407609
47	nucleoside transmembrane transport (GO:1901642)	3.47424856
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45524299
49	NADH dehydrogenase complex assembly (GO:0010257)	3.45524299
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45524299
51	GTP biosynthetic process (GO:0006183)	3.42712417
52	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.36797384
53	substrate-independent telencephalic tangential migration (GO:0021826)	3.36797384
54	protein deneddylation (GO:0000338)	3.31278409
55	protein polyglutamylation (GO:0018095)	3.27546273
56	GDP-mannose metabolic process (GO:0019673)	3.25998934
57	establishment of protein localization to membrane (GO:0090150)	3.22874629
58	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.16478499
59	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.15047148
60	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11160574
61	outer ear morphogenesis (GO:0042473)	3.10554414
62	UTP metabolic process (GO:0046051)	3.09957731
63	nonmotile primary cilium assembly (GO:0035058)	3.09300466
64	mannose metabolic process (GO:0006013)	3.04243860
65	protein targeting (GO:0006605)	3.03603193
66	UTP biosynthetic process (GO:0006228)	3.01629022
67	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.96930118
68	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.96930118
69	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.96910848
70	protein-cofactor linkage (GO:0018065)	2.94741842
71	water-soluble vitamin biosynthetic process (GO:0042364)	2.93102015
72	parturition (GO:0007567)	2.86653033
73	hydrogen ion transmembrane transport (GO:1902600)	2.85561251
74	establishment of protein localization to organelle (GO:0072594)	2.84968489
75	interferon-gamma production (GO:0032609)	2.84070328
76	intracellular protein transmembrane import (GO:0044743)	2.82213492
77	nucleoside triphosphate biosynthetic process (GO:0009142)	2.81402138
78	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81153779
79	nucleoside transport (GO:0015858)	2.75598150
80	transmission of nerve impulse (GO:0019226)	2.73503169
81	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67316003
82	axon ensheathment in central nervous system (GO:0032291)	2.66896380
83	central nervous system myelination (GO:0022010)	2.66896380
84	protein localization to membrane (GO:0072657)	2.66490367
85	pyrimidine nucleotide catabolic process (GO:0006244)	2.64273938
86	short-term memory (GO:0007614)	2.63431976
87	regulation of cellular respiration (GO:0043457)	2.59831142
88	rRNA processing (GO:0006364)	2.57112139
89	endoderm formation (GO:0001706)	2.56704103
90	platelet dense granule organization (GO:0060155)	2.52541591
91	rRNA metabolic process (GO:0016072)	2.52147004
92	cardiovascular system development (GO:0072358)	2.51969156
93	amine catabolic process (GO:0009310)	2.51318564
94	cellular biogenic amine catabolic process (GO:0042402)	2.51318564
95	hydrogen transport (GO:0006818)	2.51260584
96	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49863947
97	proton transport (GO:0015992)	2.49700539
98	positive regulation of fatty acid transport (GO:2000193)	2.42084277
99	ribosome biogenesis (GO:0042254)	2.41933779
100	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.41818206

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.91758754
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.30404487
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36280192
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.35500350
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.18693205
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60598528
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58792083
8	VDR_22108803_ChIP-Seq_LS180_Human	2.54164522
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.44416397
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.36910107
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.11241440
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09429184
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08135038
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00539533
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.99478568
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.97381416
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.96676305
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.80925130
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.77440971
20	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.75311862
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73072731
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.72305416
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70682222
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68852990
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.68847892
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.64865273
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60757868
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.53085564
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52364908
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51102227
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49676110
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48974811
33	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.46571682
34	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.41775521
35	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.41328549
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40936301
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.39480270
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38726117
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.36186168
40	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.35207464
41	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34141297
42	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.34055069
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33163738
44	FUS_26573619_Chip-Seq_HEK293_Human	1.31865265
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.30593832
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30043170
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.29582038
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26811137
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.26324142
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.25130313
51	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.24180712
52	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.24180712
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24179856
54	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.23965123
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22974829
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.22776468
57	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20562869
58	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19910294
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.17876892
60	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17436817
61	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.17275431
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.17011848
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16088822
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16078872
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14510764
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13374720
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12816496
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12218449
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.11779488
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10156443
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09466225
72	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.08980685
73	SA1_27219007_Chip-Seq_Bcells_Human	1.07419377
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07184882
75	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06846237
76	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.06648589
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06173325
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05240427
79	NCOR_22424771_ChIP-Seq_293T_Human	1.05222089
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03593646
81	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03387294
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01542845
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01315652
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01185359
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01185359
86	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00067545
87	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.99323744
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98799092
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98308254
90	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98160702
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97867244
92	EWS_26573619_Chip-Seq_HEK293_Human	0.97796899
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97735862
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97096481
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96942768
96	ERA_21632823_ChIP-Seq_H3396_Human	0.96777565
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95358770
98	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92936456
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92883635
100	AR_20517297_ChIP-Seq_VCAP_Human	0.92398985

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.59463604
2	MP0006292_abnormal_olfactory_placode	4.50231275
3	MP0002638_abnormal_pupillary_reflex	4.38532102
4	MP0003011_delayed_dark_adaptation	3.50486779
5	MP0003646_muscle_fatigue	2.59121138
6	MP0001529_abnormal_vocalization	2.32556148
7	MP0006072_abnormal_retinal_apoptosis	2.32021258
8	MP0002163_abnormal_gland_morphology	2.06855574
9	MP0008789_abnormal_olfactory_epithelium	2.05617057
10	MP0004142_abnormal_muscle_tone	2.05115661
11	MP0003787_abnormal_imprinting	2.04777794
12	MP0002837_dystrophic_cardiac_calcinosis	2.01395015
13	MP0003122_maternal_imprinting	1.90220774
14	MP0001905_abnormal_dopamine_level	1.81874324
15	MP0003880_abnormal_central_pattern	1.79289572
16	MP0005253_abnormal_eye_physiology	1.74109083
17	MP0005379_endocrine/exocrine_gland_phen	1.73600743
18	MP0008877_abnormal_DNA_methylation	1.68545710
19	MP0005377_hearing/vestibular/ear_phenot	1.66831107
20	MP0003878_abnormal_ear_physiology	1.66831107
21	MP0001293_anophthalmia	1.65620896
22	MP0005646_abnormal_pituitary_gland	1.63096712
23	MP0005394_taste/olfaction_phenotype	1.61810326
24	MP0005499_abnormal_olfactory_system	1.61810326
25	MP0000049_abnormal_middle_ear	1.57998715
26	MP0002234_abnormal_pharynx_morphology	1.54994323
27	MP0005671_abnormal_response_to	1.49781371
28	MP0002160_abnormal_reproductive_system	1.49526577
29	MP0006276_abnormal_autonomic_nervous	1.46453724
30	MP0002653_abnormal_ependyma_morphology	1.43332063
31	MP0005551_abnormal_eye_electrophysiolog	1.43133491
32	MP0001727_abnormal_embryo_implantation	1.42794622
33	MP0005083_abnormal_biliary_tract	1.41706220
34	MP0005084_abnormal_gallbladder_morpholo	1.41140889
35	MP0000778_abnormal_nervous_system	1.35051046
36	MP0005195_abnormal_posterior_eye	1.32134295
37	MP0005085_abnormal_gallbladder_physiolo	1.32074794
38	MP0001502_abnormal_circadian_rhythm	1.28832126
39	MP0004885_abnormal_endolymph	1.28214363
40	MP0003123_paternal_imprinting	1.27253725
41	MP0002736_abnormal_nociception_after	1.26860206
42	MP0003136_yellow_coat_color	1.24975582
43	MP0009046_muscle_twitch	1.21662617
44	MP0001968_abnormal_touch/_nociception	1.21626665
45	MP0005389_reproductive_system_phenotype	1.21109346
46	MP0004145_abnormal_muscle_electrophysio	1.20492056
47	MP0010030_abnormal_orbit_morphology	1.18503353
48	MP0010386_abnormal_urinary_bladder	1.16943044
49	MP0008875_abnormal_xenobiotic_pharmacok	1.15070711
50	MP0002102_abnormal_ear_morphology	1.14258482
51	MP0003121_genomic_imprinting	1.13957455
52	MP0002272_abnormal_nervous_system	1.09839143
53	MP0000631_abnormal_neuroendocrine_gland	1.07872208
54	MP0005391_vision/eye_phenotype	1.06228758
55	MP0009745_abnormal_behavioral_response	1.06047386
56	MP0005423_abnormal_somatic_nervous	1.04911728
57	MP0002752_abnormal_somatic_nervous	1.02850289
58	MP0002876_abnormal_thyroid_physiology	1.01541131
59	MP0002184_abnormal_innervation	1.00875139
60	MP0008775_abnormal_heart_ventricle	1.00375805
61	MP0009053_abnormal_anal_canal	0.99520365
62	MP0001485_abnormal_pinna_reflex	0.97706191
63	MP0003567_abnormal_fetal_cardiomyocyte	0.97666342
64	MP0002557_abnormal_social/conspecific_i	0.96142970
65	MP0002572_abnormal_emotion/affect_behav	0.93479584
66	MP0003879_abnormal_hair_cell	0.93192961
67	MP0000026_abnormal_inner_ear	0.92411086
68	MP0006082_CNS_inflammation	0.91782987
69	MP0004133_heterotaxia	0.91705236
70	MP0005360_urolithiasis	0.89571151
71	MP0001970_abnormal_pain_threshold	0.87558832
72	MP0003937_abnormal_limbs/digits/tail_de	0.87067871
73	MP0002733_abnormal_thermal_nociception	0.86820174
74	MP0004742_abnormal_vestibular_system	0.85844350
75	MP0000955_abnormal_spinal_cord	0.84803271
76	MP0001542_abnormal_bone_strength	0.84332607
77	MP0001440_abnormal_grooming_behavior	0.84011658
78	MP0001919_abnormal_reproductive_system	0.81101757
79	MP0000678_abnormal_parathyroid_gland	0.81003968
80	MP0008872_abnormal_physiological_respon	0.79979029
81	MP0003186_abnormal_redox_activity	0.79854848
82	MP0009250_abnormal_appendicular_skeleto	0.78115226
83	MP0001286_abnormal_eye_development	0.76858302
84	MP0002210_abnormal_sex_determination	0.76418904
85	MP0002928_abnormal_bile_duct	0.76089819
86	MP0002233_abnormal_nose_morphology	0.74514899
87	MP0001188_hyperpigmentation	0.74424847
88	MP0004043_abnormal_pH_regulation	0.73547611
89	MP0001348_abnormal_lacrimal_gland	0.72457434
90	MP0001486_abnormal_startle_reflex	0.71620070
91	MP0004924_abnormal_behavior	0.69899016
92	MP0005386_behavior/neurological_phenoty	0.69899016
93	MP0002095_abnormal_skin_pigmentation	0.69251279
94	MP0002938_white_spotting	0.69170687
95	MP0002138_abnormal_hepatobiliary_system	0.68281008
96	MP0003195_calcinosis	0.68077156
97	MP0003938_abnormal_ear_development	0.67979106
98	MP0001986_abnormal_taste_sensitivity	0.67852292
99	MP0001963_abnormal_hearing_physiology	0.66444722
100	MP0002277_abnormal_respiratory_mucosa	0.66100353

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.06547828
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.98289089
3	Macrocytic anemia (HP:0001972)	4.40382053
4	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.93537649
5	Acute necrotizing encephalopathy (HP:0006965)	3.80116491
6	Abnormality of midbrain morphology (HP:0002418)	3.60829620
7	Molar tooth sign on MRI (HP:0002419)	3.60829620
8	Abnormal number of erythroid precursors (HP:0012131)	3.58532749
9	Mitochondrial inheritance (HP:0001427)	3.47417159
10	3-Methylglutaconic aciduria (HP:0003535)	3.44149065
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42682465
12	Pallor (HP:0000980)	3.40347030
13	Increased CSF lactate (HP:0002490)	3.16557409
14	Progressive macrocephaly (HP:0004481)	3.09648743
15	Acute encephalopathy (HP:0006846)	3.07466064
16	Patent foramen ovale (HP:0001655)	2.95319268
17	Septo-optic dysplasia (HP:0100842)	2.93138077
18	Stenosis of the external auditory canal (HP:0000402)	2.88760965
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88286440
20	Congenital stationary night blindness (HP:0007642)	2.84819126
21	Hyperglycinemia (HP:0002154)	2.78752135
22	Absent thumb (HP:0009777)	2.76489516
23	Hepatocellular necrosis (HP:0001404)	2.73746511
24	Renal Fanconi syndrome (HP:0001994)	2.69494882
25	Dyskinesia (HP:0100660)	2.62683611
26	Maternal diabetes (HP:0009800)	2.58623113
27	Global brain atrophy (HP:0002283)	2.58355075
28	Hepatic necrosis (HP:0002605)	2.56617746
29	Increased hepatocellular lipid droplets (HP:0006565)	2.56274060
30	Nephronophthisis (HP:0000090)	2.56011873
31	Myokymia (HP:0002411)	2.53944753
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.51892380
33	Pancreatic fibrosis (HP:0100732)	2.51039456
34	Congenital, generalized hypertrichosis (HP:0004540)	2.50614334
35	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.48797823
36	Pancreatic cysts (HP:0001737)	2.48080499
37	True hermaphroditism (HP:0010459)	2.43141486
38	Medial flaring of the eyebrow (HP:0010747)	2.39986436
39	Partial duplication of the phalanx of hand (HP:0009999)	2.32850839
40	Microretrognathia (HP:0000308)	2.29528585
41	Lipid accumulation in hepatocytes (HP:0006561)	2.28634299
42	Sclerocornea (HP:0000647)	2.28212451
43	Dysphonia (HP:0001618)	2.24721096
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.19429587
45	Adrenal hypoplasia (HP:0000835)	2.19003091
46	Abolished electroretinogram (ERG) (HP:0000550)	2.18385857
47	Cerebral edema (HP:0002181)	2.18102874
48	Anencephaly (HP:0002323)	2.16578521
49	Optic disc pallor (HP:0000543)	2.13816220
50	Increased serum lactate (HP:0002151)	2.11189727
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09824126
52	Rib fusion (HP:0000902)	2.09038949
53	Pendular nystagmus (HP:0012043)	2.07901528
54	Agitation (HP:0000713)	2.07617105
55	Increased intramyocellular lipid droplets (HP:0012240)	2.06090548
56	Depressed nasal ridge (HP:0000457)	2.05266192
57	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.04436731
58	Type II lissencephaly (HP:0007260)	2.03616660
59	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.03114175
60	Akinesia (HP:0002304)	1.99985987
61	Hypobetalipoproteinemia (HP:0003563)	1.98655839
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98580240
63	Triphalangeal thumb (HP:0001199)	1.95356026
64	Methylmalonic acidemia (HP:0002912)	1.94184074
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.93760133
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.93760133
67	Morphological abnormality of the pyramidal tract (HP:0002062)	1.91918287
68	Cerebellar dysplasia (HP:0007033)	1.91446699
69	Lactic acidosis (HP:0003128)	1.91373307
70	Hypoplasia of the ulna (HP:0003022)	1.91145866
71	Colon cancer (HP:0003003)	1.90876669
72	Optic nerve hypoplasia (HP:0000609)	1.90814026
73	Generalized aminoaciduria (HP:0002909)	1.90349115
74	Decreased muscle mass (HP:0003199)	1.90231793
75	Gait imbalance (HP:0002141)	1.89533073
76	Chronic bronchitis (HP:0004469)	1.89401616
77	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88242926
78	Abnormality of the renal medulla (HP:0100957)	1.87955197
79	Abnormality of magnesium homeostasis (HP:0004921)	1.87893572
80	Abnormality of renal resorption (HP:0011038)	1.86875854
81	Anophthalmia (HP:0000528)	1.86563749
82	Congenital primary aphakia (HP:0007707)	1.86212405
83	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.86177816
84	Poor suck (HP:0002033)	1.85496308
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85020696
86	Focal dystonia (HP:0004373)	1.84602413
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.83316007
88	Hypoplasia of the radius (HP:0002984)	1.82582859
89	Abnormality of alanine metabolism (HP:0010916)	1.82473781
90	Hyperalaninemia (HP:0003348)	1.82473781
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.82473781
92	Asplenia (HP:0001746)	1.81667994
93	Craniofacial dystonia (HP:0012179)	1.81198861
94	Leukodystrophy (HP:0002415)	1.80532003
95	Recurrent gram-negative bacterial infections (HP:0005420)	1.80037216
96	Male pseudohermaphroditism (HP:0000037)	1.79712555
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78019569
98	Porencephaly (HP:0002132)	1.74993553
99	Elevated erythrocyte sedimentation rate (HP:0003565)	1.73775441
100	Glycosuria (HP:0003076)	1.72898758

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CA	3.06674609
2	NME1	2.65242956
3	STK16	2.55672694
4	CDK19	2.53770077
5	PRKCH	2.46026834
6	ZAK	2.41934152
7	NME2	2.38357669
8	DYRK2	2.25896036
9	NUAK1	2.17693201
10	GRK1	2.12518521
11	TXK	2.01644244
12	ADRBK2	1.96430806
13	BCKDK	1.94981209
14	TIE1	1.92185436
15	WNK4	1.86589383
16	TLK1	1.78367255
17	MAP2K6	1.60938729
18	PDK2	1.58335438
19	PBK	1.56159396
20	LIMK1	1.44269677
21	PIM2	1.41537203
22	FRK	1.38423140
23	EPHA4	1.36846740
24	PASK	1.29258877
25	PINK1	1.26839684
26	WNK3	1.26175370
27	PRKCQ	1.25910154
28	MAP2K7	1.18688230
29	PRKCG	1.18358650
30	ABL2	1.18057115
31	LRRK2	1.17776617
32	INSRR	1.15604548
33	MAP4K1	1.14306290
34	TEC	1.13175732
35	ADRBK1	1.06075891
36	OXSR1	1.05717435
37	MAP4K2	1.01847046
38	ITK	0.99288018
39	NTRK2	0.97365646
40	BRAF	0.95940901
41	RPS6KA6	0.95810137
42	CAMK1	0.93508823
43	MAP3K9	0.93290370
44	MAP3K11	0.93106891
45	BMPR1B	0.92606957
46	ARAF	0.91910975
47	MAPK13	0.88968968
48	PIM1	0.85734370
49	AURKA	0.85009265
50	NTRK3	0.83195662
51	OBSCN	0.82376770
52	CDC7	0.80600160
53	PRKACA	0.80329493
54	LCK	0.79971457
55	DYRK3	0.79432649
56	PLK4	0.76521758
57	RPS6KC1	0.74414892
58	RPS6KL1	0.74414892
59	AKT2	0.72354604
60	MAP2K4	0.70549735
61	CAMK2A	0.70523903
62	MAP3K4	0.70479915
63	RPS6KA5	0.70415507
64	FES	0.69925923
65	CAMK2D	0.69327611
66	TAOK3	0.69165159
67	TYRO3	0.68185638
68	PRKCD	0.67349011
69	MAP3K6	0.66687246
70	MINK1	0.66241365
71	RPS6KA2	0.63098437
72	VRK1	0.62203799
73	CSNK2A2	0.61752236
74	PHKG2	0.61619688
75	PHKG1	0.61619688
76	KDR	0.57989664
77	TGFBR1	0.57911909
78	STK11	0.57628113
79	CSNK1G2	0.57264209
80	STK39	0.56952445
81	IKBKB	0.56890107
82	CSNK2A1	0.55584932
83	PRKCA	0.53303931
84	CAMK2G	0.52668252
85	PIK3CG	0.52181960
86	DYRK1B	0.51064411
87	PLK1	0.50810792
88	PKN1	0.50198864
89	SGK223	0.49975487
90	SGK494	0.49975487
91	EPHB2	0.49763830
92	ATR	0.47823437
93	CSNK1G3	0.47432834
94	BTK	0.45741375
95	DMPK	0.45609354
96	CAMKK2	0.44766538
97	MAP2K2	0.44251431
98	MAPK15	0.43632822
99	RPS6KA1	0.43460982
100	DAPK3	0.43313263

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.10673805
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.25319867
3	Parkinsons disease_Homo sapiens_hsa05012	3.66558447
4	RNA polymerase_Homo sapiens_hsa03020	2.93932404
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.57453340
6	Huntingtons disease_Homo sapiens_hsa05016	2.52170247
7	Alzheimers disease_Homo sapiens_hsa05010	2.45873173
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.43755220
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26008729
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05053066
11	Sulfur relay system_Homo sapiens_hsa04122	1.98883130
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.92548331
13	Asthma_Homo sapiens_hsa05310	1.90619497
14	Allograft rejection_Homo sapiens_hsa05330	1.89198260
15	Protein export_Homo sapiens_hsa03060	1.72642674
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71968592
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.55920278
18	RNA degradation_Homo sapiens_hsa03018	1.44914941
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41212383
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40921887
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36315045
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33825881
23	Phototransduction_Homo sapiens_hsa04744	1.33778166
24	Proteasome_Homo sapiens_hsa03050	1.32261549
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32098862
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29751294
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22322297
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.07296240
29	Sulfur metabolism_Homo sapiens_hsa00920	1.06879808
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.06751015
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.04665665
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04041749
33	One carbon pool by folate_Homo sapiens_hsa00670	1.03286516
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00885751
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00503093
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.00121482
37	Basal transcription factors_Homo sapiens_hsa03022	0.98187725
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93813026
39	Purine metabolism_Homo sapiens_hsa00230	0.93704042
40	Homologous recombination_Homo sapiens_hsa03440	0.93039758
41	Mismatch repair_Homo sapiens_hsa03430	0.89554858
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.87142176
43	Retinol metabolism_Homo sapiens_hsa00830	0.83486505
44	Regulation of autophagy_Homo sapiens_hsa04140	0.83091912
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81468115
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79548598
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.76857795
48	Olfactory transduction_Homo sapiens_hsa04740	0.76844060
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.74364820
50	Butanoate metabolism_Homo sapiens_hsa00650	0.74108035
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73458956
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71083151
53	Viral myocarditis_Homo sapiens_hsa05416	0.71076957
54	Metabolic pathways_Homo sapiens_hsa01100	0.68873754
55	Caffeine metabolism_Homo sapiens_hsa00232	0.68245549
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68195059
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.66956862
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66773567
59	Nicotine addiction_Homo sapiens_hsa05033	0.64832976
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64660915
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63279658
62	Morphine addiction_Homo sapiens_hsa05032	0.62564631
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61956432
64	DNA replication_Homo sapiens_hsa03030	0.58944268
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57452471
66	Spliceosome_Homo sapiens_hsa03040	0.57037127
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53795134
68	Folate biosynthesis_Homo sapiens_hsa00790	0.53469187
69	Peroxisome_Homo sapiens_hsa04146	0.52851025
70	Base excision repair_Homo sapiens_hsa03410	0.52300341
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49698191
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49303175
73	Malaria_Homo sapiens_hsa05144	0.48705295
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46742219
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44375421
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44237991
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43537754
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43295088
79	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.43026767
80	Taste transduction_Homo sapiens_hsa04742	0.38664271
81	Fatty acid elongation_Homo sapiens_hsa00062	0.37792223
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37078932
83	Glutathione metabolism_Homo sapiens_hsa00480	0.35453665
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.34729302
85	GABAergic synapse_Homo sapiens_hsa04727	0.34049319
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33743536
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31010418
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30790160
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.29815410
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29207639
91	Propanoate metabolism_Homo sapiens_hsa00640	0.29152079
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28614463
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28149874
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28026134
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27270710
96	Serotonergic synapse_Homo sapiens_hsa04726	0.27194418
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.26449919
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.25831952
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24715538
100	Insulin secretion_Homo sapiens_hsa04911	0.23308983

RPS7P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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