RPS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.94008680
2ribosomal small subunit assembly (GO:0000028)8.71533851
3* translational termination (GO:0006415)8.61256100
4ribosomal small subunit biogenesis (GO:0042274)7.92550161
5* translational elongation (GO:0006414)7.45686249
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.19524266
7* cotranslational protein targeting to membrane (GO:0006613)7.04954956
8* protein targeting to ER (GO:0045047)7.04874944
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.87684603
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.73422719
11* cellular protein complex disassembly (GO:0043624)6.68027493
12* viral life cycle (GO:0019058)6.66134449
13* protein localization to endoplasmic reticulum (GO:0070972)6.57779342
14* translational initiation (GO:0006413)6.56615034
15* maturation of SSU-rRNA (GO:0030490)6.12678941
16ribosomal large subunit biogenesis (GO:0042273)5.95381711
17* protein complex disassembly (GO:0043241)5.94570123
18* macromolecular complex disassembly (GO:0032984)5.54337402
19* nuclear-transcribed mRNA catabolic process (GO:0000956)5.00117620
20ribonucleoprotein complex biogenesis (GO:0022613)4.76610579
21* mRNA catabolic process (GO:0006402)4.75164556
22* protein targeting to membrane (GO:0006612)4.69693672
23formation of translation preinitiation complex (GO:0001731)4.67121357
24* translation (GO:0006412)4.56694582
25* RNA catabolic process (GO:0006401)4.49701691
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44091048
27DNA unwinding involved in DNA replication (GO:0006268)4.28019056
28chaperone-mediated protein transport (GO:0072321)4.16651798
29ATP synthesis coupled proton transport (GO:0015986)4.15404245
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15404245
31DNA strand elongation involved in DNA replication (GO:0006271)4.03430146
32DNA strand elongation (GO:0022616)3.82176439
33* rRNA processing (GO:0006364)3.80024358
34heterochromatin organization (GO:0070828)3.79768378
35telomere maintenance via semi-conservative replication (GO:0032201)3.78168226
36DNA deamination (GO:0045006)3.69832406
37DNA replication initiation (GO:0006270)3.68295583
38* rRNA metabolic process (GO:0016072)3.67209941
39regulation of mitochondrial translation (GO:0070129)3.58950382
40negative regulation of RNA splicing (GO:0033119)3.50821797
41* protein localization to membrane (GO:0072657)3.45471624
42cellular component biogenesis (GO:0044085)3.42931006
43embryonic skeletal joint morphogenesis (GO:0060272)3.35378107
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.35319575
45establishment of integrated proviral latency (GO:0075713)3.31935466
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31628784
47protein localization to kinetochore (GO:0034501)3.30619295
48ncRNA 3-end processing (GO:0043628)3.24446018
49telomere maintenance via recombination (GO:0000722)3.23415470
50folic acid-containing compound biosynthetic process (GO:0009396)3.22041916
51ribosome biogenesis (GO:0042254)3.17839973
52* establishment of protein localization to membrane (GO:0090150)3.17199131
53spliceosomal snRNP assembly (GO:0000387)3.13781420
54respiratory electron transport chain (GO:0022904)3.10081792
55mitotic recombination (GO:0006312)3.07499911
56ribosome assembly (GO:0042255)3.07249523
57nucleobase biosynthetic process (GO:0046112)3.06171114
58pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.04298421
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02404961
60electron transport chain (GO:0022900)2.99941845
61protein targeting to mitochondrion (GO:0006626)2.99638992
62telomere maintenance via telomere lengthening (GO:0010833)2.98306574
63pseudouridine synthesis (GO:0001522)2.96624022
64* establishment of protein localization to organelle (GO:0072594)2.95713855
65DNA replication checkpoint (GO:0000076)2.95683705
66spliceosomal complex assembly (GO:0000245)2.94845418
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92338103
68nucleotide-excision repair, DNA gap filling (GO:0006297)2.92129339
69pyrimidine nucleotide catabolic process (GO:0006244)2.92041652
70IMP biosynthetic process (GO:0006188)2.91402793
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90542775
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89936848
73* protein localization to organelle (GO:0033365)2.89274717
74DNA replication-dependent nucleosome organization (GO:0034723)2.89200831
75DNA replication-dependent nucleosome assembly (GO:0006335)2.89200831
76* protein targeting (GO:0006605)2.87855877
77mitotic nuclear envelope disassembly (GO:0007077)2.86483788
78protein localization to chromosome, centromeric region (GO:0071459)2.85446345
79mRNA splicing, via spliceosome (GO:0000398)2.78550498
80RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78550498
81RNA splicing, via transesterification reactions (GO:0000375)2.77644102
82chromatin remodeling at centromere (GO:0031055)2.77209354
83CENP-A containing nucleosome assembly (GO:0034080)2.76812487
84establishment of protein localization to mitochondrion (GO:0072655)2.71932274
85termination of RNA polymerase II transcription (GO:0006369)2.70005506
86mitotic chromosome condensation (GO:0007076)2.69075211
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.68881280
88ribonucleoprotein complex assembly (GO:0022618)2.68829734
89UTP biosynthetic process (GO:0006228)2.67832224
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67765672
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.67476611
92termination of RNA polymerase III transcription (GO:0006386)2.67476611
93* gene expression (GO:0010467)2.67185698
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.65755713
95NADH dehydrogenase complex assembly (GO:0010257)2.65755713
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65755713
97DNA replication-independent nucleosome organization (GO:0034724)2.64002649
98DNA replication-independent nucleosome assembly (GO:0006336)2.64002649
99DNA topological change (GO:0006265)2.63461460
100myeloid cell homeostasis (GO:0002262)2.63333546
101* ncRNA processing (GO:0034470)2.63180455
102negative regulation of mRNA processing (GO:0050686)2.63134301
103IMP metabolic process (GO:0046040)2.62718920
104membrane disassembly (GO:0030397)2.62240323
105nuclear envelope disassembly (GO:0051081)2.62240323
106guanosine-containing compound biosynthetic process (GO:1901070)2.62166531
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62072634
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61602015
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59541077
110nucleobase-containing small molecule interconversion (GO:0015949)2.58749973
111purine nucleobase biosynthetic process (GO:0009113)2.58597909
112transcription-coupled nucleotide-excision repair (GO:0006283)2.57700074
113regulation of protein heterodimerization activity (GO:0043497)2.57132481
114* cellular component disassembly (GO:0022411)2.56718805
115protein localization to mitochondrion (GO:0070585)2.55246507
116kinetochore organization (GO:0051383)2.54697060
117ribonucleoprotein complex subunit organization (GO:0071826)2.53559890
118DNA duplex unwinding (GO:0032508)2.52121968
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51990049
120mitotic metaphase plate congression (GO:0007080)2.51350789
121chromatin assembly or disassembly (GO:0006333)2.51093804
122negative regulation of ligase activity (GO:0051352)2.50269721
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50269721
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49288359
125DNA geometric change (GO:0032392)2.49184614
126* ncRNA metabolic process (GO:0034660)2.49120316
127establishment of viral latency (GO:0019043)2.48588541
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48108239
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47879828
130pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.47528043
131proteasome assembly (GO:0043248)2.47388685
132regulation of histone H3-K9 methylation (GO:0051570)2.47052028
133regulation of translational fidelity (GO:0006450)2.46787246
134histone mRNA metabolic process (GO:0008334)2.46582642
135mitochondrial respiratory chain complex assembly (GO:0033108)2.45404335
136chromatin assembly (GO:0031497)2.44242214
137CTP biosynthetic process (GO:0006241)2.43350784
138CTP metabolic process (GO:0046036)2.43350784
139DNA-templated transcription, termination (GO:0006353)2.40952575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89827697
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.63424165
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08738633
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.43138064
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24463477
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.15691111
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01248344
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.88662510
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79684015
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.78003429
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76315899
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.69116572
13* XRN2_22483619_ChIP-Seq_HELA_Human2.63119519
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61991701
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43956163
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41504600
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40997850
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35856099
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22648400
20MYC_22102868_ChIP-Seq_BL_Human2.18444681
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16426720
22VDR_23849224_ChIP-Seq_CD4+_Human2.14110842
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09424841
24* TTF2_22483619_ChIP-Seq_HELA_Human2.03026210
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99908194
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94140068
27FOXP3_21729870_ChIP-Seq_TREG_Human1.89872982
28* DCP1A_22483619_ChIP-Seq_HELA_Human1.87629655
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.86516349
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85604705
31VDR_21846776_ChIP-Seq_THP-1_Human1.75287366
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71104880
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70701439
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.68732745
35CIITA_25753668_ChIP-Seq_RAJI_Human1.65630283
36GABP_19822575_ChIP-Seq_HepG2_Human1.65090045
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62320948
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.61779829
39ELK1_19687146_ChIP-ChIP_HELA_Human1.61108530
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59618521
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57250038
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56127510
43AR_21909140_ChIP-Seq_LNCAP_Human1.52603831
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51225711
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51202343
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49744756
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49526373
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44149675
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41197880
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41086749
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38250441
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38228090
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35637266
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33536013
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32672453
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32327858
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31527096
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.31098360
59* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30423465
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.29515228
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28807207
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28287589
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26046539
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23206231
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20159478
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18935928
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18291785
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.16461491
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16257433
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16102891
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16067699
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15863717
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14802242
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14286714
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12912110
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12366141
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.11625196
78SPI1_23547873_ChIP-Seq_NB4_Human1.09998329
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08615070
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.08433220
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.08116627
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07860864
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.07053321
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04107283
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.02035177
86TFEB_21752829_ChIP-Seq_HELA_Human1.01926994
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01866761
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00412215
89ZNF263_19887448_ChIP-Seq_K562_Human1.00104295
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98938726
91MYC_18940864_ChIP-ChIP_HL60_Human0.98713811
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98541510
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98165117
94* UTX_26944678_Chip-Seq_JUKART_Human0.96415593
95MAF_26560356_Chip-Seq_TH1_Human0.96134216
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95808128
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94565592
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94408029
99CHD1_26751641_Chip-Seq_LNCaP_Human0.93870093
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93850087
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93610374
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93575705
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93006509
104* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92931531
105MAF_26560356_Chip-Seq_TH2_Human0.92833938
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92646335
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92646335
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92646335
109* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91513325
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91184418
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90645974
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89456422
113SCL_19346495_ChIP-Seq_HPC-7_Human0.88533361
114LXR_22292898_ChIP-Seq_THP-1_Human0.88418719
115* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87943811
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87607912
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.87380912
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87357141
119* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86014492
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85445878
121* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84564696
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84246951
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83049761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58036404
2MP0004957_abnormal_blastocyst_morpholog3.87683480
3MP0006292_abnormal_olfactory_placode3.66009095
4MP0009379_abnormal_foot_pigmentation3.44007316
5MP0010094_abnormal_chromosome_stability3.30201428
6MP0003111_abnormal_nucleus_morphology3.28637267
7MP0003077_abnormal_cell_cycle3.24164568
8MP0008057_abnormal_DNA_replication2.71105550
9MP0002396_abnormal_hematopoietic_system2.67336905
10MP0002163_abnormal_gland_morphology2.66758611
11MP0010352_gastrointestinal_tract_polyps2.34698751
12MP0008058_abnormal_DNA_repair2.20650713
13MP0008007_abnormal_cellular_replicative2.14675368
14MP0008932_abnormal_embryonic_tissue2.05306394
15MP0000490_abnormal_crypts_of2.00088286
16MP0004808_abnormal_hematopoietic_stem1.95377955
17MP0001730_embryonic_growth_arrest1.92088055
18MP0000350_abnormal_cell_proliferation1.88974107
19MP0003123_paternal_imprinting1.88240821
20MP0000678_abnormal_parathyroid_gland1.86109125
21MP0000049_abnormal_middle_ear1.83466735
22MP0002160_abnormal_reproductive_system1.80655259
23MP0009333_abnormal_splenocyte_physiolog1.75920546
24MP0003763_abnormal_thymus_physiology1.75248512
25MP0000566_synostosis1.67781505
26MP0003786_premature_aging1.61431038
27MP0004858_abnormal_nervous_system1.58578061
28MP0002249_abnormal_larynx_morphology1.55482505
29MP0006054_spinal_hemorrhage1.52584139
30MP0003567_abnormal_fetal_cardiomyocyte1.51320189
31MP0005397_hematopoietic_system_phenotyp1.49477360
32MP0001545_abnormal_hematopoietic_system1.49477360
33MP0003942_abnormal_urinary_system1.48896839
34MP0010030_abnormal_orbit_morphology1.47013229
35MP0002398_abnormal_bone_marrow1.43550451
36MP0002019_abnormal_tumor_incidence1.42564402
37MP0009250_abnormal_appendicular_skeleto1.42062666
38MP0000703_abnormal_thymus_morphology1.41819452
39MP0001697_abnormal_embryo_size1.39606176
40MP0000537_abnormal_urethra_morphology1.39412108
41MP0002080_prenatal_lethality1.37496845
42MP0002722_abnormal_immune_system1.35254472
43MP0008995_early_reproductive_senescence1.32731952
44MP0000313_abnormal_cell_death1.31302360
45MP0004197_abnormal_fetal_growth/weight/1.30617853
46MP0000685_abnormal_immune_system1.29929237
47MP0001672_abnormal_embryogenesis/_devel1.29577765
48MP0005380_embryogenesis_phenotype1.29577765
49MP0009278_abnormal_bone_marrow1.28263200
50MP0003937_abnormal_limbs/digits/tail_de1.27383793
51MP0002085_abnormal_embryonic_tissue1.23645194
52MP0000465_gastrointestinal_hemorrhage1.21589586
53MP0000689_abnormal_spleen_morphology1.21358247
54MP0003941_abnormal_skin_development1.21288753
55MP0010307_abnormal_tumor_latency1.21283498
56MP0002697_abnormal_eye_size1.20677586
57MP0002084_abnormal_developmental_patter1.20605830
58MP0001286_abnormal_eye_development1.20142100
59MP0002086_abnormal_extraembryonic_tissu1.19489834
60MP0005379_endocrine/exocrine_gland_phen1.18137993
61MP0003186_abnormal_redox_activity1.17415227
62MP0003984_embryonic_growth_retardation1.17214464
63MP0002088_abnormal_embryonic_growth/wei1.16426294
64MP0005501_abnormal_skin_physiology1.13653606
65MP0001800_abnormal_humoral_immune1.12722807
66MP0002429_abnormal_blood_cell1.12591476
67MP0003136_yellow_coat_color1.12489823
68MP0001188_hyperpigmentation1.11944554
69MP0000858_altered_metastatic_potential1.10364359
70MP0005174_abnormal_tail_pigmentation1.09940787
71MP0000428_abnormal_craniofacial_morphol1.07008375
72MP0005023_abnormal_wound_healing1.05413222
73MP0001853_heart_inflammation1.04967840
74MP0000716_abnormal_immune_system1.04764268
75MP0002166_altered_tumor_susceptibility1.04133976
76MP0002092_abnormal_eye_morphology1.03440812
77MP0003315_abnormal_perineum_morphology1.02057526
78MP0005389_reproductive_system_phenotype1.01639472
79MP0001835_abnormal_antigen_presentation1.01468979
80MP0003705_abnormal_hypodermis_morpholog1.01193651
81MP0005076_abnormal_cell_differentiation1.01094177
82MP0003938_abnormal_ear_development1.00385214
83MP0001873_stomach_inflammation0.99204043
84MP0002132_abnormal_respiratory_system0.98410428
85MP0002420_abnormal_adaptive_immunity0.97964483
86MP0002009_preneoplasia0.97211797
87MP0004185_abnormal_adipocyte_glucose0.96935471
88MP0003566_abnormal_cell_adhesion0.96633034
89MP0000631_abnormal_neuroendocrine_gland0.96619588
90MP0001819_abnormal_immune_cell0.95621036
91MP0003385_abnormal_body_wall0.93972802
92MP0001293_anophthalmia0.93803773
93MP0002452_abnormal_antigen_presenting0.93741756
94MP0005408_hypopigmentation0.93412389
95MP0002405_respiratory_system_inflammati0.93033296
96MP0002932_abnormal_joint_morphology0.92376301
97MP0010234_abnormal_vibrissa_follicle0.92224326
98MP0010155_abnormal_intestine_physiology0.90625111
99MP0002796_impaired_skin_barrier0.90612688
100MP0001145_abnormal_male_reproductive0.89844111
101MP0002006_tumorigenesis0.88795493
102MP0001881_abnormal_mammary_gland0.88782004
103MP0002877_abnormal_melanocyte_morpholog0.85703982
104MP0000477_abnormal_intestine_morphology0.85425204
105MP0002723_abnormal_immune_serum0.84058006
106MP0003866_abnormal_defecation0.83754145
107MP0008789_abnormal_olfactory_epithelium0.81640879
108MP0006036_abnormal_mitochondrial_physio0.81284618
109MP0005187_abnormal_penis_morphology0.80530026
110MP0002095_abnormal_skin_pigmentation0.79919619
111MP0005671_abnormal_response_to0.79590807
112MP0009053_abnormal_anal_canal0.79068720
113MP0009672_abnormal_birth_weight0.78130597
114MP0002114_abnormal_axial_skeleton0.77968176
115MP0005499_abnormal_olfactory_system0.77543560
116MP0005394_taste/olfaction_phenotype0.77543560
117MP0005025_abnormal_response_to0.77073942
118MP0002116_abnormal_craniofacial_bone0.76776253
119MP0002111_abnormal_tail_morphology0.76741687
120MP0001849_ear_inflammation0.76461781
121MP0001216_abnormal_epidermal_layer0.76209318
122MP0001346_abnormal_lacrimal_gland0.76138316
123MP0000762_abnormal_tongue_morphology0.75950327
124MP0000534_abnormal_ureter_morphology0.74675719
125MP0005075_abnormal_melanosome_morpholog0.74392515
126MP0000681_abnormal_thyroid_gland0.74321928
127MP0000358_abnormal_cell_content/0.73330723
128MP0003436_decreased_susceptibility_to0.72953419
129MP0003121_genomic_imprinting0.72615785
130MP0003861_abnormal_nervous_system0.72124050
131MP0000653_abnormal_sex_gland0.71678964
132MP0003755_abnormal_palate_morphology0.71361155
133MP0000750_abnormal_muscle_regeneration0.71160885
134MP0002938_white_spotting0.70425690
135MP0002233_abnormal_nose_morphology0.69828791
136MP0001727_abnormal_embryo_implantation0.69683383
137MP0005000_abnormal_immune_tolerance0.69289218
138MP0000733_abnormal_muscle_development0.67643134
139MP0003718_maternal_effect0.67348664
140MP0009931_abnormal_skin_appearance0.66689986
141MP0006035_abnormal_mitochondrial_morpho0.66365779
142MP0004947_skin_inflammation0.65721616
143MP0003119_abnormal_digestive_system0.65417212
144MP0004133_heterotaxia0.65357425
145MP0002060_abnormal_skin_morphology0.65086510
146MP0001270_distended_abdomen0.64629679
147MP0001919_abnormal_reproductive_system0.64306345
148MP0001915_intracranial_hemorrhage0.64167957
149MP0002210_abnormal_sex_determination0.64061295
150MP0003448_altered_tumor_morphology0.63605681
151MP0008770_decreased_survivor_rate0.63546231
152MP0005623_abnormal_meninges_morphology0.63133863

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.06286307
2Abnormal number of erythroid precursors (HP:0012131)8.01728821
3Reticulocytopenia (HP:0001896)7.57741058
4Macrocytic anemia (HP:0001972)5.64079314
5Pallor (HP:0000980)5.38213758
6Thrombocytosis (HP:0001894)3.97287967
7Colon cancer (HP:0003003)3.89520985
8Acute necrotizing encephalopathy (HP:0006965)3.43001557
9Abnormal mitochondria in muscle tissue (HP:0008316)3.39251677
10Aplastic anemia (HP:0001915)3.32203655
11Broad distal phalanx of finger (HP:0009836)3.17935843
12Selective tooth agenesis (HP:0001592)3.11548270
13Oral leukoplakia (HP:0002745)3.10003007
143-Methylglutaconic aciduria (HP:0003535)2.98114663
1511 pairs of ribs (HP:0000878)2.97770123
16Absent thumb (HP:0009777)2.93807112
17Acute encephalopathy (HP:0006846)2.87320101
18Short middle phalanx of the 5th finger (HP:0004220)2.83687788
19Abnormality of reticulocytes (HP:0004312)2.81112619
20Birth length less than 3rd percentile (HP:0003561)2.79155963
21Mitochondrial inheritance (HP:0001427)2.76535310
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76160699
23Multiple enchondromatosis (HP:0005701)2.73572894
24Trismus (HP:0000211)2.71465107
25Microvesicular hepatic steatosis (HP:0001414)2.63882354
26Increased CSF lactate (HP:0002490)2.61652369
27IgM deficiency (HP:0002850)2.60078056
28Progressive macrocephaly (HP:0004481)2.52327993
29Asplenia (HP:0001746)2.49327357
30Breast hypoplasia (HP:0003187)2.48681072
31Stenosis of the external auditory canal (HP:0000402)2.45903167
32Basal cell carcinoma (HP:0002671)2.45714255
33Microretrognathia (HP:0000308)2.42169171
34Hepatocellular necrosis (HP:0001404)2.40521615
35Depressed nasal ridge (HP:0000457)2.38714828
36Abnormal hemoglobin (HP:0011902)2.35001399
37Rough bone trabeculation (HP:0100670)2.34629257
38Increased intramyocellular lipid droplets (HP:0012240)2.34035780
39Carpal bone hypoplasia (HP:0001498)2.33747938
40Abnormality of the phalanges of the hallux (HP:0010057)2.32426064
41Abnormal number of incisors (HP:0011064)2.31925888
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.28287638
43Cerebral edema (HP:0002181)2.27045711
44Abnormality of the 4th metacarpal (HP:0010012)2.25295922
45Myelodysplasia (HP:0002863)2.25154164
46Hepatic necrosis (HP:0002605)2.24320364
47Missing ribs (HP:0000921)2.23984046
48Duplication of thumb phalanx (HP:0009942)2.22666852
49Ectopic kidney (HP:0000086)2.20824245
50Lipid accumulation in hepatocytes (HP:0006561)2.19962106
51Neoplasm of the pancreas (HP:0002894)2.18900376
52Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.17702797
53Ependymoma (HP:0002888)2.16943026
54Atresia of the external auditory canal (HP:0000413)2.16611083
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15105016
56Glossoptosis (HP:0000162)2.15079983
57Patellar aplasia (HP:0006443)2.14970523
58Abnormality of the parietal bone (HP:0002696)2.13819229
59Thick lower lip vermilion (HP:0000179)2.13655977
60Increased serum lactate (HP:0002151)2.08638631
61Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08314576
62Migraine (HP:0002076)2.07907798
63Aplasia/Hypoplasia of the patella (HP:0006498)2.06158963
64Truncus arteriosus (HP:0001660)2.04756098
65Hypoplasia of the radius (HP:0002984)2.03925320
66Hyperthyroidism (HP:0000836)2.01695400
67Squamous cell carcinoma (HP:0002860)2.01289516
68Increased muscle lipid content (HP:0009058)2.00643048
69Proximal placement of thumb (HP:0009623)1.99234115
70Pseudobulbar signs (HP:0002200)1.97702656
71Deep palmar crease (HP:0006191)1.96550092
72Petechiae (HP:0000967)1.93455699
73Medulloblastoma (HP:0002885)1.93151809
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93138189
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93138189
76Congenital, generalized hypertrichosis (HP:0004540)1.90166157
77Abnormality of cochlea (HP:0000375)1.89951401
78Spinal cord lesions (HP:0100561)1.89871521
79Syringomyelia (HP:0003396)1.89871521
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.89560152
81Triphalangeal thumb (HP:0001199)1.89192868
82Poikiloderma (HP:0001029)1.88836935
83Cellular immunodeficiency (HP:0005374)1.88500109
84Deviation of the thumb (HP:0009603)1.87157204
85Premature graying of hair (HP:0002216)1.86664164
86Cleft eyelid (HP:0000625)1.86640868
87Exercise intolerance (HP:0003546)1.86391186
88Chronic otitis media (HP:0000389)1.86002088
89Short 5th finger (HP:0009237)1.84606271
90Transposition of the great arteries (HP:0001669)1.84224637
91Abnormal connection of the cardiac segments (HP:0011545)1.84224637
92Abnormal ventriculo-arterial connection (HP:0011563)1.84224637
93Amaurosis fugax (HP:0100576)1.81224177
94Abnormality of the fetal cardiovascular system (HP:0010948)1.81028569
95Abnormal umbilical cord blood vessels (HP:0011403)1.81028569
96Single umbilical artery (HP:0001195)1.81028569
97Lactic acidosis (HP:0003128)1.80488997
98Premature ovarian failure (HP:0008209)1.80239528
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79451455
100Lymphoma (HP:0002665)1.78951668
101Abnormality of the preputium (HP:0100587)1.78428449
102Woolly hair (HP:0002224)1.76389401
103Down-sloping shoulders (HP:0200021)1.75755588
104Bicuspid aortic valve (HP:0001647)1.75540545
105Dysphonia (HP:0001618)1.75274865
106Tracheoesophageal fistula (HP:0002575)1.74610618
107Abnormality of the middle phalanges of the toes (HP:0010183)1.74474295
108Degeneration of anterior horn cells (HP:0002398)1.73150999
109Abnormality of the anterior horn cell (HP:0006802)1.73150999
110Elevated erythrocyte sedimentation rate (HP:0003565)1.72946435
111Renal Fanconi syndrome (HP:0001994)1.71397336
112Forearm undergrowth (HP:0009821)1.71058568
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71022478
114Facial cleft (HP:0002006)1.70397932
115Horseshoe kidney (HP:0000085)1.68488263
116Agnosia (HP:0010524)1.67641531
117Pancytopenia (HP:0001876)1.67087688
118Septate vagina (HP:0001153)1.67050407
119Meckel diverticulum (HP:0002245)1.66686589
120Testicular atrophy (HP:0000029)1.66184007
121Abnormality of DNA repair (HP:0003254)1.65821846
122Hypoparathyroidism (HP:0000829)1.65274841
123Septo-optic dysplasia (HP:0100842)1.64912558
124Recurrent bronchitis (HP:0002837)1.63286332
125Absent radius (HP:0003974)1.62118419
126Abnormality of the ileum (HP:0001549)1.60883829
127Abnormal trabecular bone morphology (HP:0100671)1.59928769
128Mesangial abnormality (HP:0001966)1.59204914
129Increased hepatocellular lipid droplets (HP:0006565)1.59084857
130Sparse eyelashes (HP:0000653)1.58997755
131Progressive muscle weakness (HP:0003323)1.56282664
132Exertional dyspnea (HP:0002875)1.55834402
133Bone marrow hypocellularity (HP:0005528)1.55249683
134Acute lymphatic leukemia (HP:0006721)1.55095607
135Rectal prolapse (HP:0002035)1.54332991
136Pili torti (HP:0003777)1.54314003
137Angiofibromas (HP:0010615)1.53597241
138Adenoma sebaceum (HP:0009720)1.53597241
139Neoplasm of the colon (HP:0100273)1.53118029
140Short thumb (HP:0009778)1.52748192
141Abnormality of T cell physiology (HP:0011840)1.52517671
142Respiratory difficulties (HP:0002880)1.52398578
143Chromsome breakage (HP:0040012)1.52312447
144Partial duplication of thumb phalanx (HP:0009944)1.51226385
145Slender long bone (HP:0003100)1.50514353
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.50297585
147Rhabdomyosarcoma (HP:0002859)1.50213835
148Aplasia/Hypoplasia of the thymus (HP:0010515)1.49948646
149Abnormality of T cells (HP:0002843)1.49858117
150Partial duplication of the phalanx of hand (HP:0009999)1.49630086
151Muscle fiber atrophy (HP:0100295)1.48428380
152Sparse lateral eyebrow (HP:0005338)1.47983521
153Esophageal atresia (HP:0002032)1.47887462
154Abnormal lung lobation (HP:0002101)1.47814483
155Abnormality of chromosome stability (HP:0003220)1.47740922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.38704486
2EEF2K3.58730278
3BUB13.47830986
4WEE13.38484391
5RPS6KB22.95813303
6CDC72.81360124
7SMG12.78936564
8LRRK22.43278269
9VRK22.37718921
10PDK22.37000485
11MAP4K12.18131745
12TLK12.14967820
13NEK22.12692966
14MAP3K102.09134711
15PKN22.05690632
16TGFBR12.04485953
17PASK1.93606246
18SRPK11.85287832
19TSSK61.74229436
20EIF2AK11.72465264
21IRAK31.64979500
22PIM21.64364418
23DYRK31.64289302
24VRK11.63546568
25ICK1.60369134
26STK161.51457557
27RPS6KA41.50754516
28CDK71.50644177
29ARAF1.45808747
30AURKB1.44071053
31MKNK11.43134888
32TESK21.39485733
33STK101.37773051
34EIF2AK31.34645474
35MAP3K81.32333299
36TRIB31.29788820
37MAP2K31.29045445
38FLT31.25518052
39CDK41.24909819
40BRAF1.24625875
41ILK1.23279964
42PAK41.23149129
43MAPKAPK31.22786575
44ACVR1B1.21401472
45TAF11.21122998
46TTK1.21081840
47PRPF4B1.20939730
48SCYL21.20600570
49PLK11.19046453
50EPHA21.16522144
51BRSK21.15583343
52ATR1.12693359
53BTK1.11846980
54KDR1.10669908
55CDK121.04887618
56PIM11.04801540
57MST41.00641871
58PBK1.00368962
59GRK60.97463360
60ZAP700.90110655
61AURKA0.87190956
62PLK40.83848020
63STK40.83463470
64CHEK10.82597305
65SIK10.82374785
66MAP3K30.82151658
67NEK10.80687850
68NME10.78053738
69CSNK2A20.77194695
70MKNK20.76592806
71CDK190.76162734
72DYRK20.75808219
73PAK20.75653078
74KIT0.74702259
75MAP3K130.74127684
76RPS6KA50.71431328
77ALK0.70406324
78ZAK0.69828459
79PAK10.68969663
80TYK20.68677134
81MAP3K110.68239722
82CHEK20.67726102
83CDK60.67526447
84IRAK20.66192381
85TEC0.65375111
86ABL20.64441602
87EPHB20.64216022
88IRAK40.60544782
89MAP2K20.60192061
90CCNB10.59223203
91BLK0.59023281
92JAK30.58691739
93CSNK2A10.57117164
94CDK20.56763157
95CDK80.55844223
96STK240.54997036
97WNK40.54777363
98CSF1R0.54631163
99TYRO30.54592314
100CLK10.53994915
101ERN10.53300837
102BCKDK0.52703455
103CSNK1E0.51991461
104ATM0.49334589
105DMPK0.49236209
106BRD40.49023081
107PLK30.48877943
108IKBKB0.48445538
109DYRK1B0.48084157
110SYK0.47266498
111BRSK10.45700412
112MARK30.44604857
113AKT20.44355224
114TESK10.43012005
115MAPK150.42749881
116PRKCI0.42465564
117RPS6KL10.40372588
118RPS6KC10.40372588
119CAMK1G0.40342614
120RPS6KA60.39616100
121DAPK30.39102902
122AKT10.37523762
123CAMK1D0.36797679
124LCK0.36223483
125TTN0.36109432
126MAP3K90.35806628
127NLK0.35570972
128MTOR0.34743343
129RPS6KB10.33779431
130PRKDC0.33676972
131MAPKAPK20.33222561
132CDK30.32941106
133RAF10.32762962
134RPS6KA10.32216629
135PNCK0.32178921
136KSR20.31971454
137PTK60.31213868
138WNK10.30322009
139CDK10.29368651

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.00173703
2DNA replication_Homo sapiens_hsa030304.35581385
3Mismatch repair_Homo sapiens_hsa034303.54084181
4Spliceosome_Homo sapiens_hsa030403.32991433
5Proteasome_Homo sapiens_hsa030503.06296482
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98143700
7RNA polymerase_Homo sapiens_hsa030202.97362820
8RNA transport_Homo sapiens_hsa030132.60896554
9Base excision repair_Homo sapiens_hsa034102.54241643
10Nucleotide excision repair_Homo sapiens_hsa034202.46720507
11Homologous recombination_Homo sapiens_hsa034402.35810791
12Pyrimidine metabolism_Homo sapiens_hsa002402.25379006
13One carbon pool by folate_Homo sapiens_hsa006702.09322108
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04674304
15Cell cycle_Homo sapiens_hsa041101.98230181
16RNA degradation_Homo sapiens_hsa030181.59485021
17Non-homologous end-joining_Homo sapiens_hsa034501.52225275
18Fanconi anemia pathway_Homo sapiens_hsa034601.51994875
19p53 signaling pathway_Homo sapiens_hsa041151.39588129
20Systemic lupus erythematosus_Homo sapiens_hsa053221.38952378
21mRNA surveillance pathway_Homo sapiens_hsa030151.38522053
22Basal transcription factors_Homo sapiens_hsa030221.30399200
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23801733
24Cardiac muscle contraction_Homo sapiens_hsa042601.19095180
25Epstein-Barr virus infection_Homo sapiens_hsa051691.15421653
26Parkinsons disease_Homo sapiens_hsa050121.10895818
27Antigen processing and presentation_Homo sapiens_hsa046121.10890211
28Primary immunodeficiency_Homo sapiens_hsa053401.10524405
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01769063
30Purine metabolism_Homo sapiens_hsa002301.01634803
31Protein export_Homo sapiens_hsa030601.01591860
32Herpes simplex infection_Homo sapiens_hsa051680.98810907
33Sulfur relay system_Homo sapiens_hsa041220.97818966
34Huntingtons disease_Homo sapiens_hsa050160.95483232
35Viral carcinogenesis_Homo sapiens_hsa052030.92989874
36Oxidative phosphorylation_Homo sapiens_hsa001900.90456175
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85650751
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.85465461
39HTLV-I infection_Homo sapiens_hsa051660.82633191
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82066231
41Small cell lung cancer_Homo sapiens_hsa052220.77361127
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74240919
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72159528
44Thyroid cancer_Homo sapiens_hsa052160.71611203
45Pentose phosphate pathway_Homo sapiens_hsa000300.70758867
46Pyruvate metabolism_Homo sapiens_hsa006200.69094782
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68090415
48Hematopoietic cell lineage_Homo sapiens_hsa046400.64318412
49Chronic myeloid leukemia_Homo sapiens_hsa052200.61317996
50Acute myeloid leukemia_Homo sapiens_hsa052210.61114714
51Apoptosis_Homo sapiens_hsa042100.60333385
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57154005
53Folate biosynthesis_Homo sapiens_hsa007900.56892907
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56176233
55MicroRNAs in cancer_Homo sapiens_hsa052060.54903024
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54754609
57Measles_Homo sapiens_hsa051620.53913422
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.53426449
59Carbon metabolism_Homo sapiens_hsa012000.53018980
60Alcoholism_Homo sapiens_hsa050340.52759748
61Notch signaling pathway_Homo sapiens_hsa043300.52615321
62Alzheimers disease_Homo sapiens_hsa050100.52489318
63Legionellosis_Homo sapiens_hsa051340.52366059
64Basal cell carcinoma_Homo sapiens_hsa052170.52234285
65N-Glycan biosynthesis_Homo sapiens_hsa005100.50377307
66B cell receptor signaling pathway_Homo sapiens_hsa046620.47828257
67Shigellosis_Homo sapiens_hsa051310.47614324
68Hepatitis B_Homo sapiens_hsa051610.47235854
69Bladder cancer_Homo sapiens_hsa052190.45840876
70Metabolic pathways_Homo sapiens_hsa011000.45172513
71Vitamin B6 metabolism_Homo sapiens_hsa007500.43907695
72Biosynthesis of amino acids_Homo sapiens_hsa012300.42927492
73Glutathione metabolism_Homo sapiens_hsa004800.41853162
74Colorectal cancer_Homo sapiens_hsa052100.41188558
75Oocyte meiosis_Homo sapiens_hsa041140.39370100
76Pathways in cancer_Homo sapiens_hsa052000.38562820
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.38528833
78HIF-1 signaling pathway_Homo sapiens_hsa040660.38292154
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38130610
80TGF-beta signaling pathway_Homo sapiens_hsa043500.37677786
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.37021493
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.36787929
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35001186
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34449331
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.34076668
86Pancreatic cancer_Homo sapiens_hsa052120.33312290
87Leishmaniasis_Homo sapiens_hsa051400.32559557
88Wnt signaling pathway_Homo sapiens_hsa043100.32060198
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.31701439
90Melanoma_Homo sapiens_hsa052180.30486866
91Viral myocarditis_Homo sapiens_hsa054160.30347638
92Selenocompound metabolism_Homo sapiens_hsa004500.29902065
93T cell receptor signaling pathway_Homo sapiens_hsa046600.29462553
94Toxoplasmosis_Homo sapiens_hsa051450.29361980
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.28404364
96Hippo signaling pathway_Homo sapiens_hsa043900.28103580
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28061343
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28044168
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26789896
100Influenza A_Homo sapiens_hsa051640.26510357
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26318526
102Non-small cell lung cancer_Homo sapiens_hsa052230.26175352
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25652792
104Asthma_Homo sapiens_hsa053100.25520063
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24873985
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24855097
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24619843
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23932760
109Hedgehog signaling pathway_Homo sapiens_hsa043400.23432054
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22031281
111Platelet activation_Homo sapiens_hsa046110.21919630
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21453380
113Arginine and proline metabolism_Homo sapiens_hsa003300.21119860
114Vitamin digestion and absorption_Homo sapiens_hsa049770.20989682
115Proteoglycans in cancer_Homo sapiens_hsa052050.20642066
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20180757
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20031322
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19339357
119Galactose metabolism_Homo sapiens_hsa000520.17527031
120Prostate cancer_Homo sapiens_hsa052150.13837297
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13488781
122mTOR signaling pathway_Homo sapiens_hsa041500.12699008
123Endometrial cancer_Homo sapiens_hsa052130.10757596
124Tyrosine metabolism_Homo sapiens_hsa003500.09090386
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09085621
126Lysine degradation_Homo sapiens_hsa003100.08941359
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08490838
128Renal cell carcinoma_Homo sapiens_hsa052110.08166844
129VEGF signaling pathway_Homo sapiens_hsa043700.07752632
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07214641

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