RPS8P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.65603640
2ribosomal small subunit biogenesis (GO:0042274)8.61161567
3translational termination (GO:0006415)8.27501814
4maturation of SSU-rRNA (GO:0030490)8.17519298
5chaperone-mediated protein transport (GO:0072321)7.24185151
6ribosomal small subunit assembly (GO:0000028)7.04726783
7translational elongation (GO:0006414)7.00417813
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.84164347
9protein targeting to ER (GO:0045047)6.74611422
10cotranslational protein targeting to membrane (GO:0006613)6.73575130
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.46236919
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.31438399
13protein localization to endoplasmic reticulum (GO:0070972)6.30524934
14cellular protein complex disassembly (GO:0043624)6.28801814
15viral life cycle (GO:0019058)6.23125766
16ATP synthesis coupled proton transport (GO:0015986)5.80290324
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80290324
18translational initiation (GO:0006413)5.47261231
19protein complex disassembly (GO:0043241)5.34195601
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16614794
21activation of MAPKKK activity (GO:0000185)5.12555464
22macromolecular complex disassembly (GO:0032984)5.05385699
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.70252723
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.67816581
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.67816581
26NADH dehydrogenase complex assembly (GO:0010257)4.67816581
27behavioral response to nicotine (GO:0035095)4.63705482
28protein targeting to membrane (GO:0006612)4.55199710
29translation (GO:0006412)4.43061209
30protein complex biogenesis (GO:0070271)4.42522474
31nuclear-transcribed mRNA catabolic process (GO:0000956)4.42471354
32DNA deamination (GO:0045006)4.32756097
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.28697898
34mRNA catabolic process (GO:0006402)4.19164687
35respiratory electron transport chain (GO:0022904)4.18571441
36protein neddylation (GO:0045116)4.16996047
37electron transport chain (GO:0022900)4.16868004
38mitochondrial respiratory chain complex assembly (GO:0033108)4.15808674
39rRNA transcription (GO:0009303)4.02237556
40cellular component biogenesis (GO:0044085)3.98561364
41ribosomal large subunit biogenesis (GO:0042273)3.96368758
42ribonucleoprotein complex biogenesis (GO:0022613)3.96180630
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.92569559
44positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.91100900
45resolution of meiotic recombination intermediates (GO:0000712)3.89042521
46RNA catabolic process (GO:0006401)3.74209597
47pattern specification involved in kidney development (GO:0061004)3.68716859
48rRNA metabolic process (GO:0016072)3.61115274
49leukocyte aggregation (GO:0070486)3.59685587
50pseudouridine synthesis (GO:0001522)3.51872463
51ATP biosynthetic process (GO:0006754)3.46387172
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.45998752
53GTP biosynthetic process (GO:0006183)3.44768754
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38064011
55pyrimidine nucleotide catabolic process (GO:0006244)3.37403511
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33381292
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29207205
58rRNA processing (GO:0006364)3.28389625
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.23889123
60termination of RNA polymerase III transcription (GO:0006386)3.23889123
61water-soluble vitamin biosynthetic process (GO:0042364)3.21854598
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15411280
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.14212368
64substrate-independent telencephalic tangential migration (GO:0021826)3.14212368
65protein targeting (GO:0006605)3.12960098
66establishment of protein localization to membrane (GO:0090150)3.08346265
67myoblast migration (GO:0051451)3.06657560
68ribonucleoside triphosphate biosynthetic process (GO:0009201)3.04344914
69intracellular protein transmembrane import (GO:0044743)3.01646796
70peptidyl-histidine modification (GO:0018202)2.97283749
71positive regulation of signal transduction by p53 class mediator (GO:1901798)2.97214975
72cell proliferation in forebrain (GO:0021846)2.96701773
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95481560
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95481560
75meiotic chromosome segregation (GO:0045132)2.93280577
76UTP biosynthetic process (GO:0006228)2.91964770
77establishment of protein localization to organelle (GO:0072594)2.89073430
78segment specification (GO:0007379)2.88391226
79protein targeting to mitochondrion (GO:0006626)2.87774424
80glycoprotein catabolic process (GO:0006516)2.81515920
81hydrogen ion transmembrane transport (GO:1902600)2.81286948
82establishment of protein localization to mitochondrion (GO:0072655)2.75965528
83pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75570244
84positive regulation of vascular permeability (GO:0043117)2.74559160
85nonmotile primary cilium assembly (GO:0035058)2.73611122
86UTP metabolic process (GO:0046051)2.72712147
87protein-cofactor linkage (GO:0018065)2.72169743
88ubiquinone biosynthetic process (GO:0006744)2.70949978
89ncRNA 3-end processing (GO:0043628)2.66651967
90iron-sulfur cluster assembly (GO:0016226)2.66076983
91metallo-sulfur cluster assembly (GO:0031163)2.66076983
92cardiovascular system development (GO:0072358)2.65317068
93reciprocal DNA recombination (GO:0035825)2.64785425
94reciprocal meiotic recombination (GO:0007131)2.64785425
95inner mitochondrial membrane organization (GO:0007007)2.63191442
96epithelial cilium movement (GO:0003351)2.62404465
97male meiosis I (GO:0007141)2.61217053
98nucleoside triphosphate biosynthetic process (GO:0009142)2.61050324
99spinal cord development (GO:0021510)2.60472555
100positive regulation of defense response to virus by host (GO:0002230)2.59549240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19130742
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51397969
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.35162731
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28381843
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99593847
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.97115027
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.88332038
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81150439
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69029122
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.49811010
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34502308
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25200397
13YY1_21170310_ChIP-Seq_MESCs_Mouse2.23796503
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19796576
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19223788
16XRN2_22483619_ChIP-Seq_HELA_Human2.08354538
17VDR_22108803_ChIP-Seq_LS180_Human2.05595661
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01075038
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97026342
20TTF2_22483619_ChIP-Seq_HELA_Human1.83230044
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82214444
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81465668
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79555753
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.79208147
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77990584
26FOXP3_21729870_ChIP-Seq_TREG_Human1.69810576
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61696032
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59510538
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.59470129
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.56103887
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54660654
32VDR_23849224_ChIP-Seq_CD4+_Human1.52395070
33GABP_19822575_ChIP-Seq_HepG2_Human1.51765378
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.47471578
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46249577
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45699080
37ZNF274_21170338_ChIP-Seq_K562_Hela1.45126887
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44674549
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40302501
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38710565
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.38692251
42MYC_18940864_ChIP-ChIP_HL60_Human1.38244351
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.37744359
44TAF2_19829295_ChIP-Seq_ESCs_Human1.35872593
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34919449
46TP53_22573176_ChIP-Seq_HFKS_Human1.34336675
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.33002124
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31136298
49STAT1_20625510_ChIP-Seq_HELA_Human1.28119089
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27916719
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24246096
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23252501
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23012521
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.20826530
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19762552
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19742078
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.19022046
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.16597787
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16164575
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15814561
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15789686
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14311399
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13056070
64REST_21632747_ChIP-Seq_MESCs_Mouse1.11370491
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10214058
66CIITA_25753668_ChIP-Seq_RAJI_Human1.09128811
67ELK1_19687146_ChIP-ChIP_HELA_Human1.08916592
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08689316
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08346805
70ERA_21632823_ChIP-Seq_H3396_Human1.08340012
71E2F1_20622854_ChIP-Seq_HELA_Human1.05725291
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.04727846
73SA1_27219007_Chip-Seq_Bcells_Human1.04296748
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02413352
75KDM5A_27292631_Chip-Seq_BREAST_Human1.02399100
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01926656
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01402868
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.00486614
79NANOG_20526341_ChIP-Seq_ESCs_Human0.99908667
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99528208
81EWS_26573619_Chip-Seq_HEK293_Human0.99411573
82RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99141238
83NCOR_22424771_ChIP-Seq_293T_Human0.98966531
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98307524
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.97920574
86RNF2_27304074_Chip-Seq_ESCs_Mouse0.97668462
87AR_20517297_ChIP-Seq_VCAP_Human0.96966921
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96747897
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96396460
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96384984
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96177586
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95940287
93RNF2_27304074_Chip-Seq_NSC_Mouse0.93324366
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.93238759
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.92160335
96CTCF_27219007_Chip-Seq_Bcells_Human0.91790049
97P53_21459846_ChIP-Seq_SAOS-2_Human0.90621783
98P68_20966046_ChIP-Seq_HELA_Human0.90551665
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90218063
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90026339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.34605258
2MP0006292_abnormal_olfactory_placode4.65227677
3MP0005623_abnormal_meninges_morphology4.25364396
4MP0003136_yellow_coat_color2.62559530
5MP0002938_white_spotting2.61020961
6MP0004142_abnormal_muscle_tone2.47212986
7MP0002163_abnormal_gland_morphology2.32149557
8MP0000750_abnormal_muscle_regeneration2.29969640
9MP0003787_abnormal_imprinting2.21106315
10MP0005646_abnormal_pituitary_gland2.15865432
11MP0002638_abnormal_pupillary_reflex2.14371554
12MP0003123_paternal_imprinting2.03273002
13MP0003122_maternal_imprinting1.96545588
14MP0000566_synostosis1.92806710
15MP0000049_abnormal_middle_ear1.92642416
16MP0002837_dystrophic_cardiac_calcinosis1.83463090
17MP0003121_genomic_imprinting1.82661334
18MP0009384_cardiac_valve_regurgitation1.73480783
19MP0001485_abnormal_pinna_reflex1.69513410
20MP0008789_abnormal_olfactory_epithelium1.67756335
21MP0003786_premature_aging1.65662649
22MP0006276_abnormal_autonomic_nervous1.65127336
23MP0003646_muscle_fatigue1.58187976
24MP0002653_abnormal_ependyma_morphology1.56876358
25MP0001293_anophthalmia1.53691036
26MP0008877_abnormal_DNA_methylation1.53425279
27MP0004145_abnormal_muscle_electrophysio1.44748162
28MP0005379_endocrine/exocrine_gland_phen1.44707871
29MP0000631_abnormal_neuroendocrine_gland1.40138074
30MP0002277_abnormal_respiratory_mucosa1.40040558
31MP0005551_abnormal_eye_electrophysiolog1.38338531
32MP0009046_muscle_twitch1.33827919
33MP0005499_abnormal_olfactory_system1.30841008
34MP0005394_taste/olfaction_phenotype1.30841008
35MP0002234_abnormal_pharynx_morphology1.29346943
36MP0004147_increased_porphyrin_level1.29261235
37MP0001968_abnormal_touch/_nociception1.28360390
38MP0004885_abnormal_endolymph1.28143124
39MP0010030_abnormal_orbit_morphology1.26997418
40MP0000762_abnormal_tongue_morphology1.25319888
41MP0000778_abnormal_nervous_system1.23539589
42MP0002272_abnormal_nervous_system1.19201639
43MP0001986_abnormal_taste_sensitivity1.17611960
44MP0002067_abnormal_sensory_capabilities1.16979765
45MP0002736_abnormal_nociception_after1.16403338
46MP0005195_abnormal_posterior_eye1.15449624
47MP0003938_abnormal_ear_development1.15091528
48MP0003385_abnormal_body_wall1.14617747
49MP0002876_abnormal_thyroid_physiology1.11098398
50MP0004742_abnormal_vestibular_system1.10805718
51MP0008058_abnormal_DNA_repair1.10554688
52MP0002184_abnormal_innervation1.10139287
53MP0005389_reproductive_system_phenotype1.08143568
54MP0002160_abnormal_reproductive_system1.06489127
55MP0003315_abnormal_perineum_morphology1.06144179
56MP0008872_abnormal_physiological_respon1.04382372
57MP0009745_abnormal_behavioral_response1.01131294
58MP0008775_abnormal_heart_ventricle1.00588646
59MP0001970_abnormal_pain_threshold0.99611690
60MP0000026_abnormal_inner_ear0.99066090
61MP0002752_abnormal_somatic_nervous0.98323582
62MP0002733_abnormal_thermal_nociception0.98052062
63MP0005084_abnormal_gallbladder_morpholo0.98040901
64MP0003186_abnormal_redox_activity0.96294513
65MP0002572_abnormal_emotion/affect_behav0.96129349
66MP0003879_abnormal_hair_cell0.94579160
67MP0003878_abnormal_ear_physiology0.93816302
68MP0005377_hearing/vestibular/ear_phenot0.93816302
69MP0003755_abnormal_palate_morphology0.93701195
70MP0000955_abnormal_spinal_cord0.93374833
71MP0001905_abnormal_dopamine_level0.92030529
72MP0003567_abnormal_fetal_cardiomyocyte0.91598923
73MP0002177_abnormal_outer_ear0.91308347
74MP0002063_abnormal_learning/memory/cond0.90049431
75MP0000613_abnormal_salivary_gland0.89568561
76MP0002735_abnormal_chemical_nociception0.89142500
77MP0008875_abnormal_xenobiotic_pharmacok0.88861885
78MP0003635_abnormal_synaptic_transmissio0.88390822
79MP0001919_abnormal_reproductive_system0.87566952
80MP0003693_abnormal_embryo_hatching0.87504149
81MP0002210_abnormal_sex_determination0.87471709
82MP0002095_abnormal_skin_pigmentation0.87132255
83MP0002249_abnormal_larynx_morphology0.84869131
84MP0005645_abnormal_hypothalamus_physiol0.84656651
85MP0009053_abnormal_anal_canal0.84199295
86MP0009250_abnormal_appendicular_skeleto0.83632812
87MP0003890_abnormal_embryonic-extraembry0.83207526
88MP0001529_abnormal_vocalization0.82003251
89MP0000013_abnormal_adipose_tissue0.80666912
90MP0002102_abnormal_ear_morphology0.78700286
91MP0005083_abnormal_biliary_tract0.74842341
92MP0005423_abnormal_somatic_nervous0.74711319
93MP0002557_abnormal_social/conspecific_i0.72446658
94MP0002064_seizures0.71432452
95MP0002882_abnormal_neuron_morphology0.70810517
96MP0003137_abnormal_impulse_conducting0.70682592
97MP0002152_abnormal_brain_morphology0.70109951
98MP0001188_hyperpigmentation0.68911827
99MP0004133_heterotaxia0.68729784
100MP0002138_abnormal_hepatobiliary_system0.68555791

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)7.47251936
2Cerebellar dysplasia (HP:0007033)7.26318183
3Retinal atrophy (HP:0001105)6.10169607
4Hypoplasia of the pons (HP:0012110)5.83120982
5Retinal dysplasia (HP:0007973)5.82516643
6Abnormality of the pons (HP:0007361)5.30356249
7Reticulocytopenia (HP:0001896)4.52378070
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.49885749
9Acute necrotizing encephalopathy (HP:0006965)4.14190804
10Abnormality of cells of the erythroid lineage (HP:0012130)3.86281229
11Buphthalmos (HP:0000557)3.82323183
12Abnormal mitochondria in muscle tissue (HP:0008316)3.76013916
13Abnormality of midbrain morphology (HP:0002418)3.65738538
14Molar tooth sign on MRI (HP:0002419)3.65738538
15Abolished electroretinogram (ERG) (HP:0000550)3.61088789
16Pallor (HP:0000980)3.60563794
17Acute encephalopathy (HP:0006846)3.50307335
18Macrocytic anemia (HP:0001972)3.38745104
19Progressive macrocephaly (HP:0004481)3.33231837
20Fatigue (HP:0012378)3.32575677
21Mitochondrial inheritance (HP:0001427)3.31165028
22Abnormality of DNA repair (HP:0003254)3.21053978
23Aplasia/Hypoplasia affecting the retina (HP:0008061)3.17906036
24Lissencephaly (HP:0001339)3.12004215
25Severe muscular hypotonia (HP:0006829)3.08586467
26Abnormal number of erythroid precursors (HP:0012131)3.04908053
27Increased CSF lactate (HP:0002490)2.96032732
28Pancreatic fibrosis (HP:0100732)2.84005691
29Pachygyria (HP:0001302)2.74196576
30Pancreatic cysts (HP:0001737)2.58718674
313-Methylglutaconic aciduria (HP:0003535)2.56489641
32Cerebral edema (HP:0002181)2.54880369
33Nephronophthisis (HP:0000090)2.49410776
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48032993
35Meningocele (HP:0002435)2.45823687
36True hermaphroditism (HP:0010459)2.41166519
37Entropion (HP:0000621)2.36134897
38Stenosis of the external auditory canal (HP:0000402)2.36065543
39Congenital glaucoma (HP:0001087)2.35913302
40Difficulty climbing stairs (HP:0003551)2.35702710
41Lipid accumulation in hepatocytes (HP:0006561)2.30346037
42Hepatocellular necrosis (HP:0001404)2.27909572
43Septo-optic dysplasia (HP:0100842)2.27671634
44Increased hepatocellular lipid droplets (HP:0006565)2.27383288
45Absent thumb (HP:0009777)2.26094283
46Hypoplasia of the brainstem (HP:0002365)2.24125376
47Aplasia/Hypoplasia of the brainstem (HP:0007362)2.24125376
48Absent/shortened dynein arms (HP:0200106)2.22250792
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.22250792
50Megalocornea (HP:0000485)2.20833293
51Holoprosencephaly (HP:0001360)2.18820789
52Renal Fanconi syndrome (HP:0001994)2.15354603
53Colon cancer (HP:0003003)2.14573936
54Generalized hypotonia (HP:0001290)2.13924203
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12565098
56Chronic hepatic failure (HP:0100626)2.09172460
57Medial flaring of the eyebrow (HP:0010747)2.06664052
58Sclerocornea (HP:0000647)2.06166859
59Abnormality of the labia minora (HP:0012880)2.05096781
60Non-midline cleft lip (HP:0100335)2.04445421
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.04403886
62Hypoplasia of the radius (HP:0002984)2.04213083
63Hepatic necrosis (HP:0002605)2.03766238
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03357398
65Asplenia (HP:0001746)2.00779557
66Poikiloderma (HP:0001029)1.96516219
67Intellectual disability, profound (HP:0002187)1.95714226
68Abnormality of the renal medulla (HP:0100957)1.95463664
69Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.94883950
70Partial duplication of thumb phalanx (HP:0009944)1.93313598
71Increased intramyocellular lipid droplets (HP:0012240)1.90893873
72Pendular nystagmus (HP:0012043)1.88760943
73Polydipsia (HP:0001959)1.88741049
74Abnormal drinking behavior (HP:0030082)1.88741049
75Respiratory failure (HP:0002878)1.88318503
76Decreased subcutaneous fat (HP:0001002)1.88121064
77Hyperglycinemia (HP:0002154)1.87040084
78Esophageal atresia (HP:0002032)1.85279088
79Optic disc pallor (HP:0000543)1.84834534
80Severe global developmental delay (HP:0011344)1.82028820
81Cystic liver disease (HP:0006706)1.80812914
82Abnormality of the vitreous humor (HP:0004327)1.78892793
83Fragile nails (HP:0001808)1.77222734
84Myokymia (HP:0002411)1.74611204
85Increased serum lactate (HP:0002151)1.74326524
86Dandy-Walker malformation (HP:0001305)1.74276871
87Anencephaly (HP:0002323)1.73673616
88Optic nerve coloboma (HP:0000588)1.73314823
89Lactic acidosis (HP:0003128)1.72380176
90Maternal diabetes (HP:0009800)1.71564353
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68997426
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68997426
93Abnormal rod and cone electroretinograms (HP:0008323)1.68246629
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67582195
95Rib fusion (HP:0000902)1.67399489
96Tubular atrophy (HP:0000092)1.67320238
97Generalized muscle weakness (HP:0003324)1.66361091
98Increased muscle lipid content (HP:0009058)1.66353323
99Depressed nasal ridge (HP:0000457)1.65128578
100IgG deficiency (HP:0004315)1.65034238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.21938355
2STK104.31834935
3STK163.27943418
4WNK43.15639721
5DYRK22.43995966
6NME22.40386857
7BCKDK2.32057234
8STK112.32043898
9PIM12.21674663
10TLK12.14515958
11NUAK11.96709453
12CDK191.94289588
13TXK1.87951065
14PINK11.87440894
15WNK31.85225113
16ADRBK21.83613513
17GRK11.72874547
18TIE11.66656908
19CDC71.66441889
20VRK21.65399631
21PDK21.45601883
22STK391.43172364
23FRK1.40125456
24LRRK21.39341093
25NME11.36198349
26EPHB21.34917134
27CAMKK21.34316526
28CASK1.34126154
29PRKCH1.32399873
30WNK11.30983636
31PTK2B1.26805147
32NTRK21.26769187
33PLK41.23315592
34BMPR1B1.21775467
35OXSR11.16340756
36MAP3K111.14711658
37PRKCG1.13766706
38TNIK1.13210115
39TYRO31.09801199
40BUB10.99704146
41ABL20.98844275
42MAP2K20.97641769
43PRKD30.94213030
44MAP4K20.92705997
45SIK20.91605647
46ZAK0.85281788
47PIK3CA0.83470177
48NEK20.79666924
49AURKA0.79617748
50VRK10.74895326
51PRKCI0.72861287
52NEK10.72006934
53CAMK10.71347692
54CSNK2A20.71122690
55FGFR20.66901831
56RPS6KA50.66145288
57PIM20.61786201
58PHKG10.61343040
59PHKG20.61343040
60ADRBK10.61285764
61IKBKB0.61195906
62CSNK1E0.60124396
63DAPK30.58601003
64TAF10.57403899
65EIF2AK10.56752798
66PLK10.55734400
67NLK0.54970264
68MAP4K10.54906528
69TAOK30.54780132
70TEC0.54185915
71MINK10.54083173
72CAMK1D0.53959737
73MARK10.53406886
74PRKACA0.52623892
75RPS6KA60.52151833
76CSNK2A10.51366584
77AURKB0.49638179
78CSNK1G30.48576237
79INSRR0.47828201
80CSNK1G20.47261579
81PTK60.43913735
82CHEK20.43194429
83CAMKK10.42931238
84PRKCQ0.41891126
85MAP2K70.41860832
86PASK0.40453775
87DYRK1B0.37895947
88PAK30.37563284
89PRKCE0.37391501
90NTRK30.37233083
91OBSCN0.37161775
92TGFBR10.35408517
93CSNK1A10.34933750
94ITK0.34374089
95PRKCZ0.33965067
96ATR0.33921764
97CDK80.33540595
98PKN10.32861193
99STK40.32376500
100PRKCD0.32042877

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.48950754
2Oxidative phosphorylation_Homo sapiens_hsa001904.64876612
3Parkinsons disease_Homo sapiens_hsa050123.98770268
4Huntingtons disease_Homo sapiens_hsa050162.99906349
5RNA polymerase_Homo sapiens_hsa030202.84879797
6Cardiac muscle contraction_Homo sapiens_hsa042602.77065846
7Alzheimers disease_Homo sapiens_hsa050102.75191271
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55712370
9Sulfur relay system_Homo sapiens_hsa041222.27586491
10Proteasome_Homo sapiens_hsa030502.02969796
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92102479
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.85831897
13Homologous recombination_Homo sapiens_hsa034401.67634512
14Pyrimidine metabolism_Homo sapiens_hsa002401.61262252
15Linoleic acid metabolism_Homo sapiens_hsa005911.57361682
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56244960
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56133177
18Nucleotide excision repair_Homo sapiens_hsa034201.49393360
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49046446
20RNA degradation_Homo sapiens_hsa030181.43421640
21Fanconi anemia pathway_Homo sapiens_hsa034601.41870936
22Basal transcription factors_Homo sapiens_hsa030221.40161626
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39651180
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38992565
25One carbon pool by folate_Homo sapiens_hsa006701.37634260
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37238710
27Protein export_Homo sapiens_hsa030601.24816652
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16875355
29Mismatch repair_Homo sapiens_hsa034301.15664552
30DNA replication_Homo sapiens_hsa030301.13117981
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.04016327
32Spliceosome_Homo sapiens_hsa030401.00036561
33Peroxisome_Homo sapiens_hsa041460.99462732
34Purine metabolism_Homo sapiens_hsa002300.96484581
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92987284
36Sulfur metabolism_Homo sapiens_hsa009200.91591874
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87172731
38Fat digestion and absorption_Homo sapiens_hsa049750.83346848
39Nicotine addiction_Homo sapiens_hsa050330.83026632
40Asthma_Homo sapiens_hsa053100.82477377
41Base excision repair_Homo sapiens_hsa034100.81913974
42Butanoate metabolism_Homo sapiens_hsa006500.80287735
43RNA transport_Homo sapiens_hsa030130.79910617
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79469101
45Metabolic pathways_Homo sapiens_hsa011000.76462519
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72782666
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.70599994
48Propanoate metabolism_Homo sapiens_hsa006400.66328025
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64265220
50Phototransduction_Homo sapiens_hsa047440.63394016
51Ether lipid metabolism_Homo sapiens_hsa005650.62492198
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60560683
53Fatty acid degradation_Homo sapiens_hsa000710.59931517
54Arachidonic acid metabolism_Homo sapiens_hsa005900.58634495
55Basal cell carcinoma_Homo sapiens_hsa052170.57237612
56Caffeine metabolism_Homo sapiens_hsa002320.55947648
57Retinol metabolism_Homo sapiens_hsa008300.55465289
58Collecting duct acid secretion_Homo sapiens_hsa049660.54852893
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53954726
60Folate biosynthesis_Homo sapiens_hsa007900.51842353
61Chemical carcinogenesis_Homo sapiens_hsa052040.50748767
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.49320127
63Hedgehog signaling pathway_Homo sapiens_hsa043400.48771997
64Insulin secretion_Homo sapiens_hsa049110.48228901
65Nitrogen metabolism_Homo sapiens_hsa009100.48115714
66Tryptophan metabolism_Homo sapiens_hsa003800.47727054
67Olfactory transduction_Homo sapiens_hsa047400.45882174
68beta-Alanine metabolism_Homo sapiens_hsa004100.43761463
69Arginine and proline metabolism_Homo sapiens_hsa003300.43002147
70Glycerolipid metabolism_Homo sapiens_hsa005610.42731384
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41260849
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38181015
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37745938
74Steroid biosynthesis_Homo sapiens_hsa001000.37460791
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36369504
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36282075
77Allograft rejection_Homo sapiens_hsa053300.35421824
78Primary immunodeficiency_Homo sapiens_hsa053400.34050653
79Autoimmune thyroid disease_Homo sapiens_hsa053200.33964585
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33751856
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31620869
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31256302
83Fatty acid metabolism_Homo sapiens_hsa012120.31113459
84Regulation of autophagy_Homo sapiens_hsa041400.30650694
85Taste transduction_Homo sapiens_hsa047420.27085584
86Morphine addiction_Homo sapiens_hsa050320.26424892
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.26249435
88p53 signaling pathway_Homo sapiens_hsa041150.26202549
89Mineral absorption_Homo sapiens_hsa049780.25833560
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25302191
91Graft-versus-host disease_Homo sapiens_hsa053320.24057621
92Pyruvate metabolism_Homo sapiens_hsa006200.22644848
93Tyrosine metabolism_Homo sapiens_hsa003500.21436815
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21334304
95Type I diabetes mellitus_Homo sapiens_hsa049400.19771751
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.19656098
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.19322338
98Serotonergic synapse_Homo sapiens_hsa047260.17154886
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.16674762
100Thyroid hormone synthesis_Homo sapiens_hsa049180.14191939

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