ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.60091411
2	ribosomal small subunit biogenesis (GO:0042274)	7.31751447
3	ribosomal small subunit assembly (GO:0000028)	7.28014085
4	translational termination (GO:0006415)	7.26050413
5	maturation of SSU-rRNA (GO:0030490)	6.31800784
6	translational elongation (GO:0006414)	6.12753342
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.97432277
8	protein targeting to ER (GO:0045047)	5.89693233
9	cotranslational protein targeting to membrane (GO:0006613)	5.88718832
10	behavioral response to nicotine (GO:0035095)	5.85765833
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.69013010
12	cellular protein complex disassembly (GO:0043624)	5.55834093
13	protein localization to endoplasmic reticulum (GO:0070972)	5.52825168
14	viral life cycle (GO:0019058)	5.48438342
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.45179286
16	ATP synthesis coupled proton transport (GO:0015986)	5.45179286
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.35792657
18	protein neddylation (GO:0045116)	5.08872137
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.93023928
20	protein complex disassembly (GO:0043241)	4.81396626
21	translational initiation (GO:0006413)	4.79685364
22	ribosomal large subunit biogenesis (GO:0042273)	4.67654218
23	chaperone-mediated protein transport (GO:0072321)	4.64867558
24	macromolecular complex disassembly (GO:0032984)	4.56506531
25	substrate-independent telencephalic tangential migration (GO:0021826)	4.04804793
26	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.04804793
27	protein targeting to membrane (GO:0006612)	3.99914254
28	translation (GO:0006412)	3.91165353
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.84354728
30	ribonucleoprotein complex biogenesis (GO:0022613)	3.83228874
31	GTP biosynthetic process (GO:0006183)	3.77190574
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.75318145
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.66219645
34	spinal cord association neuron differentiation (GO:0021527)	3.65252131
35	respiratory electron transport chain (GO:0022904)	3.53179071
36	pyrimidine nucleobase catabolic process (GO:0006208)	3.53133892
37	electron transport chain (GO:0022900)	3.50288883
38	mRNA catabolic process (GO:0006402)	3.50279672
39	cellular component biogenesis (GO:0044085)	3.47593591
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.44665637
41	positive regulation of growth hormone secretion (GO:0060124)	3.38929842
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.38265723
43	nonmotile primary cilium assembly (GO:0035058)	3.37094179
44	cell proliferation in forebrain (GO:0021846)	3.36125203
45	ATP biosynthetic process (GO:0006754)	3.34394604
46	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.34345438
47	UTP biosynthetic process (GO:0006228)	3.24130736
48	ncRNA 3-end processing (GO:0043628)	3.15371436
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11774331
50	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11774331
51	protein complex biogenesis (GO:0070271)	3.07912688
52	RNA catabolic process (GO:0006401)	3.07113607
53	postsynaptic membrane organization (GO:0001941)	3.05166037
54	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.04207035
55	hydrogen ion transmembrane transport (GO:1902600)	2.98643959
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.98203571
57	NADH dehydrogenase complex assembly (GO:0010257)	2.98203571
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.98203571
59	UTP metabolic process (GO:0046051)	2.97545439
60	neuron fate determination (GO:0048664)	2.96289704
61	nucleobase catabolic process (GO:0046113)	2.95302114
62	synaptic transmission, cholinergic (GO:0007271)	2.95146881
63	establishment of mitochondrion localization (GO:0051654)	2.93200910
64	transmission of nerve impulse (GO:0019226)	2.91270281
65	forebrain neuron differentiation (GO:0021879)	2.87174333
66	pattern specification involved in kidney development (GO:0061004)	2.85940942
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85007749
68	cerebral cortex neuron differentiation (GO:0021895)	2.84625455
69	somite development (GO:0061053)	2.80641859
70	head development (GO:0060322)	2.79278141
71	establishment of protein localization to membrane (GO:0090150)	2.78523897
72	mitochondrion transport along microtubule (GO:0047497)	2.77104774
73	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.77104774
74	growth hormone secretion (GO:0030252)	2.76089579
75	CTP metabolic process (GO:0046036)	2.73010960
76	CTP biosynthetic process (GO:0006241)	2.73010960
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.72248052
78	rRNA processing (GO:0006364)	2.68707533
79	protein targeting (GO:0006605)	2.63588699
80	rRNA metabolic process (GO:0016072)	2.63275957
81	ganglion development (GO:0061548)	2.62472191
82	DNA deamination (GO:0045006)	2.60537528
83	neurofilament cytoskeleton organization (GO:0060052)	2.59760573
84	regulation of timing of cell differentiation (GO:0048505)	2.58924294
85	axonal fasciculation (GO:0007413)	2.57538092
86	proton transport (GO:0015992)	2.57355187
87	dendritic spine morphogenesis (GO:0060997)	2.57264011
88	positive regulation of gastrulation (GO:2000543)	2.54853397
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.54259923
90	genetic imprinting (GO:0071514)	2.53770829
91	nucleoside triphosphate biosynthetic process (GO:0009142)	2.52906794
92	regulation of synapse structural plasticity (GO:0051823)	2.51217275
93	body morphogenesis (GO:0010171)	2.50553955
94	hydrogen transport (GO:0006818)	2.49380593
95	lens fiber cell development (GO:0070307)	2.45757954
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.44676835
97	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44085262
98	establishment of protein localization to organelle (GO:0072594)	2.44053356
99	tongue development (GO:0043586)	2.42550811
100	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.41479257

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.41256850
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.76860257
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.77430602
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.09311453
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84470652
6	VDR_22108803_ChIP-Seq_LS180_Human	2.61687229
7	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.38907549
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.33648166
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28364066
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25738690
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25505291
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20261133
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.10943324
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.10295233
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.06182849
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.04935887
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.00395285
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97990552
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.93043667
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.88656275
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.87475998
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.83781176
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.75622780
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.71839192
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.66488145
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63384520
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.60158740
28	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.59071293
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.57764385
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57393969
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57393969
32	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.56598841
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56424655
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.53127481
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.52264277
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.52011393
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.50442134
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.49982507
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49755680
40	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49675870
41	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.48660863
42	XRN2_22483619_ChIP-Seq_HELA_Human	1.46915290
43	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.46641818
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.41583268
45	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.37683148
46	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34237564
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.33244904
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32202631
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29982297
50	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22349164
51	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.22066289
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.21024333
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20105267
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17232999
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.16151254
56	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16032287
57	CTCF_27219007_Chip-Seq_Bcells_Human	1.15520973
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15472737
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12730221
60	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.12513692
61	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.10864791
62	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09331715
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.08381392
64	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.08181264
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07935740
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07887269
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06885220
68	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.05865737
69	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05508041
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.04949714
71	NCOR_22424771_ChIP-Seq_293T_Human	1.03674528
72	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02969042
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.01788506
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.01692771
75	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.01616627
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.01404822
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99826150
78	ERA_21632823_ChIP-Seq_H3396_Human	0.99607631
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98078998
80	SA1_27219007_Chip-Seq_Bcells_Human	0.98017126
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96901802
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96454233
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96423203
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.96007356
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94885182
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94705443
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.94215750
88	FOXP3_21729870_ChIP-Seq_TREG_Human	0.93231231
89	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.91383382
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91287711
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90473728
92	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.90459509
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89962684
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89292637
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88553581
96	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.88030182
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86683451
98	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86013570
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.85690150
100	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.83702780

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.20474415
2	MP0006292_abnormal_olfactory_placode	3.62873257
3	MP0003122_maternal_imprinting	3.35730336
4	MP0003787_abnormal_imprinting	3.26714822
5	MP0008789_abnormal_olfactory_epithelium	2.84852006
6	MP0003123_paternal_imprinting	2.84110168
7	MP0004142_abnormal_muscle_tone	2.56822591
8	MP0002653_abnormal_ependyma_morphology	2.52860605
9	MP0003121_genomic_imprinting	2.46297307
10	MP0005499_abnormal_olfactory_system	2.39282954
11	MP0005394_taste/olfaction_phenotype	2.39282954
12	MP0008877_abnormal_DNA_methylation	2.33778197
13	MP0002822_catalepsy	2.16485704
14	MP0000778_abnormal_nervous_system	2.12777104
15	MP0001968_abnormal_touch/_nociception	2.09043056
16	MP0004885_abnormal_endolymph	1.96527307
17	MP0006276_abnormal_autonomic_nervous	1.94864357
18	MP0002163_abnormal_gland_morphology	1.90426126
19	MP0005646_abnormal_pituitary_gland	1.87264332
20	MP0003646_muscle_fatigue	1.84322656
21	MP0002733_abnormal_thermal_nociception	1.78901511
22	MP0000049_abnormal_middle_ear	1.74747533
23	MP0005423_abnormal_somatic_nervous	1.66418360
24	MP0004145_abnormal_muscle_electrophysio	1.66179142
25	MP0002095_abnormal_skin_pigmentation	1.65781005
26	MP0009745_abnormal_behavioral_response	1.61847982
27	MP0000631_abnormal_neuroendocrine_gland	1.59517102
28	MP0010030_abnormal_orbit_morphology	1.57116618
29	MP0004147_increased_porphyrin_level	1.51677497
30	MP0002734_abnormal_mechanical_nocicepti	1.49972618
31	MP0001970_abnormal_pain_threshold	1.49853225
32	MP0003879_abnormal_hair_cell	1.49571923
33	MP0001188_hyperpigmentation	1.47004145
34	MP0002272_abnormal_nervous_system	1.46976170
35	MP0002638_abnormal_pupillary_reflex	1.46606834
36	MP0002102_abnormal_ear_morphology	1.44789171
37	MP0000955_abnormal_spinal_cord	1.42195632
38	MP0003635_abnormal_synaptic_transmissio	1.41799148
39	MP0001986_abnormal_taste_sensitivity	1.40574991
40	MP0006072_abnormal_retinal_apoptosis	1.39477467
41	MP0001293_anophthalmia	1.39446284
42	MP0002837_dystrophic_cardiac_calcinosis	1.39334394
43	MP0001485_abnormal_pinna_reflex	1.36731037
44	MP0005377_hearing/vestibular/ear_phenot	1.34540495
45	MP0003878_abnormal_ear_physiology	1.34540495
46	MP0001440_abnormal_grooming_behavior	1.34348419
47	MP0002184_abnormal_innervation	1.34157354
48	MP0004742_abnormal_vestibular_system	1.33823174
49	MP0002063_abnormal_learning/memory/cond	1.33140081
50	MP0009046_muscle_twitch	1.32651152
51	MP0004133_heterotaxia	1.31290780
52	MP0002557_abnormal_social/conspecific_i	1.31234478
53	MP0003136_yellow_coat_color	1.28994859
54	MP0002572_abnormal_emotion/affect_behav	1.26289283
55	MP0000427_abnormal_hair_cycle	1.26148822
56	MP0001905_abnormal_dopamine_level	1.24495389
57	MP0003315_abnormal_perineum_morphology	1.24221227
58	MP0002735_abnormal_chemical_nociception	1.23537566
59	MP0004859_abnormal_synaptic_plasticity	1.21659532
60	MP0002064_seizures	1.21249418
61	MP0002876_abnormal_thyroid_physiology	1.21184286
62	MP0002938_white_spotting	1.19351081
63	MP0000566_synostosis	1.17539908
64	MP0001529_abnormal_vocalization	1.16570281
65	MP0002736_abnormal_nociception_after	1.09885954
66	MP0005551_abnormal_eye_electrophysiolog	1.08319096
67	MP0000026_abnormal_inner_ear	1.07950612
68	MP0002752_abnormal_somatic_nervous	1.07864383
69	MP0005645_abnormal_hypothalamus_physiol	1.05959701
70	MP0002160_abnormal_reproductive_system	1.03694472
71	MP0002067_abnormal_sensory_capabilities	1.02962672
72	MP0001984_abnormal_olfaction	1.02544627
73	MP0002277_abnormal_respiratory_mucosa	1.02098919
74	MP0008872_abnormal_physiological_respon	1.02008462
75	MP0008775_abnormal_heart_ventricle	1.01662447
76	MP0002882_abnormal_neuron_morphology	0.98335060
77	MP0001486_abnormal_startle_reflex	0.96616871
78	MP0003942_abnormal_urinary_system	0.94648958
79	MP0003283_abnormal_digestive_organ	0.94059309
80	MP0005195_abnormal_posterior_eye	0.92065798
81	MP0005379_endocrine/exocrine_gland_phen	0.91221774
82	MP0001502_abnormal_circadian_rhythm	0.90524938
83	MP0004858_abnormal_nervous_system	0.88836848
84	MP0002152_abnormal_brain_morphology	0.88634150
85	MP0003119_abnormal_digestive_system	0.87707075
86	MP0004811_abnormal_neuron_physiology	0.87312020
87	MP0003938_abnormal_ear_development	0.87262078
88	MP0002210_abnormal_sex_determination	0.85783231
89	MP0004270_analgesia	0.84503671
90	MP0005084_abnormal_gallbladder_morpholo	0.82465116
91	MP0003186_abnormal_redox_activity	0.79317740
92	MP0003861_abnormal_nervous_system	0.78336799
93	MP0003880_abnormal_central_pattern	0.74720087
94	MP0005389_reproductive_system_phenotype	0.74548804
95	MP0001348_abnormal_lacrimal_gland	0.74197387
96	MP0001286_abnormal_eye_development	0.73220012
97	MP0003936_abnormal_reproductive_system	0.71559485
98	MP0001963_abnormal_hearing_physiology	0.69775792
99	MP0002233_abnormal_nose_morphology	0.66069705
100	MP0002066_abnormal_motor_capabilities/c	0.65738296

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.49402221
2	Reticulocytopenia (HP:0001896)	4.99883577
3	Abnormal number of erythroid precursors (HP:0012131)	4.29470188
4	Acute necrotizing encephalopathy (HP:0006965)	4.23691622
5	Macrocytic anemia (HP:0001972)	4.19184033
6	Abnormality of the labia minora (HP:0012880)	3.92394294
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.76715027
8	Molar tooth sign on MRI (HP:0002419)	3.64735867
9	Abnormality of midbrain morphology (HP:0002418)	3.64735867
10	Acute encephalopathy (HP:0006846)	3.62836978
11	Stenosis of the external auditory canal (HP:0000402)	3.58524021
12	Pallor (HP:0000980)	3.50851050
13	Septo-optic dysplasia (HP:0100842)	3.48461660
14	Mitochondrial inheritance (HP:0001427)	3.40084879
15	Progressive macrocephaly (HP:0004481)	3.34780620
16	Abnormal hemoglobin (HP:0011902)	3.28276646
17	Pancreatic fibrosis (HP:0100732)	3.23548593
18	Myokymia (HP:0002411)	3.12298109
19	3-Methylglutaconic aciduria (HP:0003535)	2.97384023
20	Increased CSF lactate (HP:0002490)	2.94449901
21	True hermaphroditism (HP:0010459)	2.87197489
22	Pancreatic cysts (HP:0001737)	2.78506736
23	Polyphagia (HP:0002591)	2.69049373
24	Nephronophthisis (HP:0000090)	2.68191617
25	Medial flaring of the eyebrow (HP:0010747)	2.64680024
26	Absent septum pellucidum (HP:0001331)	2.59779786
27	Absent thumb (HP:0009777)	2.53902165
28	Abnormality of alanine metabolism (HP:0010916)	2.53052711
29	Hyperalaninemia (HP:0003348)	2.53052711
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.53052711
31	Cerebral edema (HP:0002181)	2.51703410
32	Type II lissencephaly (HP:0007260)	2.50595627
33	Sclerocornea (HP:0000647)	2.47803374
34	Optic disc pallor (HP:0000543)	2.47639271
35	Increased hepatocellular lipid droplets (HP:0006565)	2.45640989
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45427054
37	Abnormality of DNA repair (HP:0003254)	2.43128950
38	Gait imbalance (HP:0002141)	2.41379551
39	Colon cancer (HP:0003003)	2.36937173
40	Lipid accumulation in hepatocytes (HP:0006561)	2.35598252
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.33081210
42	Renal Fanconi syndrome (HP:0001994)	2.31592822
43	Depressed nasal ridge (HP:0000457)	2.31540474
44	Asplenia (HP:0001746)	2.30969669
45	Anencephaly (HP:0002323)	2.27862500
46	Sleep apnea (HP:0010535)	2.26405077
47	Congenital stationary night blindness (HP:0007642)	2.25411114
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.23189085
49	Hepatocellular necrosis (HP:0001404)	2.22127039
50	Lissencephaly (HP:0001339)	2.21987150
51	Maternal diabetes (HP:0009800)	2.21051252
52	Pendular nystagmus (HP:0012043)	2.17060915
53	Chronic hepatic failure (HP:0100626)	2.16891289
54	Abnormality of the renal medulla (HP:0100957)	2.14132221
55	Optic nerve hypoplasia (HP:0000609)	2.13573126
56	Hypoplasia of the radius (HP:0002984)	2.13036309
57	Agitation (HP:0000713)	2.12919322
58	Palpebral edema (HP:0100540)	2.03483124
59	Increased intramyocellular lipid droplets (HP:0012240)	2.03363101
60	Congenital primary aphakia (HP:0007707)	2.03075517
61	Pachygyria (HP:0001302)	2.02664168
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98271702
63	Hypoplasia of the uterus (HP:0000013)	1.97544712
64	Increased serum lactate (HP:0002151)	1.95695060
65	Nephrogenic diabetes insipidus (HP:0009806)	1.93190150
66	Hepatic necrosis (HP:0002605)	1.92969116
67	Abnormality of the septum pellucidum (HP:0007375)	1.90546543
68	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90250099
69	Cerebellar dysplasia (HP:0007033)	1.88416889
70	Partial agenesis of the corpus callosum (HP:0001338)	1.88008944
71	Abnormality of magnesium homeostasis (HP:0004921)	1.87400865
72	Male pseudohermaphroditism (HP:0000037)	1.87316626
73	Hyperthyroidism (HP:0000836)	1.87316238
74	Lactic acidosis (HP:0003128)	1.85471829
75	Cystic liver disease (HP:0006706)	1.85210470
76	Oligodactyly (hands) (HP:0001180)	1.84314397
77	Hyperglycinemia (HP:0002154)	1.82772154
78	Vaginal atresia (HP:0000148)	1.81369439
79	Anophthalmia (HP:0000528)	1.80217951
80	Genital tract atresia (HP:0001827)	1.80142904
81	Narrow forehead (HP:0000341)	1.78878885
82	Optic nerve coloboma (HP:0000588)	1.78567469
83	Abnormal eating behavior (HP:0100738)	1.77963871
84	Severe muscular hypotonia (HP:0006829)	1.76960219
85	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.74507185
86	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.74507185
87	Poor coordination (HP:0002370)	1.73589093
88	Lethargy (HP:0001254)	1.73119847
89	Poor suck (HP:0002033)	1.72277097
90	Oligomenorrhea (HP:0000876)	1.72074142
91	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.71978419
92	Failure to thrive in infancy (HP:0001531)	1.71842109
93	Horseshoe kidney (HP:0000085)	1.69765745
94	Increased muscle lipid content (HP:0009058)	1.69489665
95	Aganglionic megacolon (HP:0002251)	1.67950931
96	Adrenal hypoplasia (HP:0000835)	1.67052801
97	Abnormality of renal resorption (HP:0011038)	1.66895143
98	Triphalangeal thumb (HP:0001199)	1.66417238
99	Respiratory failure (HP:0002878)	1.66105692
100	Abnormal hair whorl (HP:0010721)	1.65788711

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.66941849
2	WNK4	3.27840011
3	INSRR	2.71852111
4	DYRK2	2.69127371
5	MARK1	2.34119828
6	NME2	2.27278134
7	WNK3	2.08043746
8	CASK	2.04155112
9	EPHB2	1.93892424
10	PHKG2	1.83235613
11	PHKG1	1.83235613
12	MAP4K2	1.81236427
13	PNCK	1.81075690
14	PRKD3	1.80112367
15	PINK1	1.78670922
16	ADRBK2	1.73720331
17	NTRK2	1.66736599
18	GRK1	1.66234095
19	CAMKK2	1.63597796
20	PIK3CA	1.57966238
21	BCKDK	1.54350201
22	MAP3K11	1.44071835
23	NUAK1	1.43914550
24	CDC7	1.43235555
25	PRKCG	1.39817161
26	PAK6	1.35151475
27	CAMK1D	1.35132954
28	CAMKK1	1.33457484
29	CDK19	1.30348138
30	CAMK1G	1.28347926
31	TLK1	1.27147065
32	TNIK	1.25919545
33	MAPK13	1.20655306
34	BMPR1B	1.19165158
35	VRK2	1.17538523
36	MINK1	1.12410754
37	TYRO3	1.11784605
38	MAP3K9	1.08887228
39	DYRK1B	1.06659937
40	CAMK1	1.04453360
41	PDK2	1.02451003
42	STK11	0.93704392
43	NTRK1	0.91753274
44	LIMK1	0.90894048
45	FRK	0.90736792
46	ABL2	0.90069057
47	WNK1	0.89491220
48	AURKA	0.86283019
49	CSNK1G2	0.85764582
50	LRRK2	0.83803919
51	RPS6KA6	0.82826725
52	ZAK	0.82305763
53	PRKCH	0.81095273
54	SIK2	0.81069602
55	NTRK3	0.80873513
56	MAP3K12	0.75945869
57	EPHA4	0.73630523
58	SGK494	0.73200305
59	SGK223	0.73200305
60	RPS6KA2	0.69927914
61	CDK8	0.69762860
62	DAPK3	0.67969202
63	TIE1	0.67652023
64	CHEK2	0.67632094
65	MAP2K7	0.67426037
66	CSNK2A2	0.67286385
67	PLK4	0.67144978
68	NEK2	0.66155126
69	ADRBK1	0.65299677
70	VRK1	0.64382436
71	PRKCQ	0.63477215
72	MAPK15	0.63173856
73	PRKACA	0.62523562
74	PAK3	0.61512505
75	BUB1	0.61264790
76	MOS	0.60816344
77	STK39	0.59337841
78	BRAF	0.59192025
79	ILK	0.58762565
80	PRKCZ	0.57570522
81	CSNK1E	0.56280100
82	RPS6KC1	0.55446772
83	RPS6KL1	0.55446772
84	FGFR2	0.53282365
85	OBSCN	0.53236039
86	RPS6KA5	0.51556282
87	CSNK2A1	0.50939764
88	CDK14	0.50783935
89	ARAF	0.49968905
90	MAPKAPK5	0.48884754
91	CAMK2A	0.48868476
92	PRKCI	0.48556068
93	CSNK1A1	0.48069019
94	DYRK1A	0.46511330
95	DMPK	0.46281861
96	CSNK1G3	0.44553044
97	SGK1	0.42927834
98	CDK5	0.42877585
99	PRKDC	0.41792816
100	AURKB	0.41477153

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.06409928
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.37736933
3	Parkinsons disease_Homo sapiens_hsa05012	3.85851485
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.11123946
5	Huntingtons disease_Homo sapiens_hsa05016	2.77159716
6	Alzheimers disease_Homo sapiens_hsa05010	2.65183524
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.33209901
8	Nicotine addiction_Homo sapiens_hsa05033	2.04959324
9	Sulfur relay system_Homo sapiens_hsa04122	2.01955789
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92585454
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82066365
12	One carbon pool by folate_Homo sapiens_hsa00670	1.81447268
13	RNA polymerase_Homo sapiens_hsa03020	1.78832893
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77440784
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74808883
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56847478
17	Proteasome_Homo sapiens_hsa03050	1.40501366
18	Protein export_Homo sapiens_hsa03060	1.39696271
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.33118232
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29690858
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28355535
22	Homologous recombination_Homo sapiens_hsa03440	1.28007867
23	RNA degradation_Homo sapiens_hsa03018	1.23686306
24	Basal transcription factors_Homo sapiens_hsa03022	1.23299839
25	Morphine addiction_Homo sapiens_hsa05032	1.19979936
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.14795849
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13122736
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.10406429
29	Phototransduction_Homo sapiens_hsa04744	1.09326402
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08708409
31	Folate biosynthesis_Homo sapiens_hsa00790	1.07664565
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.05389957
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01835557
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00580018
35	Insulin secretion_Homo sapiens_hsa04911	1.00184670
36	Butanoate metabolism_Homo sapiens_hsa00650	0.97392683
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94286062
38	Basal cell carcinoma_Homo sapiens_hsa05217	0.94208122
39	GABAergic synapse_Homo sapiens_hsa04727	0.90673402
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90477693
41	Mismatch repair_Homo sapiens_hsa03430	0.85569502
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.84242053
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82153705
44	Peroxisome_Homo sapiens_hsa04146	0.81106419
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74848631
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74644698
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74017442
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70201199
49	Metabolic pathways_Homo sapiens_hsa01100	0.69941285
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.69539367
51	Regulation of autophagy_Homo sapiens_hsa04140	0.67805823
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67115581
53	Base excision repair_Homo sapiens_hsa03410	0.66899747
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66855335
55	Spliceosome_Homo sapiens_hsa03040	0.65054840
56	Cocaine addiction_Homo sapiens_hsa05030	0.64565950
57	RNA transport_Homo sapiens_hsa03013	0.63706816
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.63493523
59	Purine metabolism_Homo sapiens_hsa00230	0.62745503
60	Propanoate metabolism_Homo sapiens_hsa00640	0.61545031
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60688320
62	Mineral absorption_Homo sapiens_hsa04978	0.59591388
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59502365
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59487997
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.58881706
66	Olfactory transduction_Homo sapiens_hsa04740	0.58679485
67	DNA replication_Homo sapiens_hsa03030	0.58639873
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58443537
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56136942
70	Caffeine metabolism_Homo sapiens_hsa00232	0.55371431
71	Taste transduction_Homo sapiens_hsa04742	0.53616466
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51025351
73	Circadian entrainment_Homo sapiens_hsa04713	0.50870738
74	Serotonergic synapse_Homo sapiens_hsa04726	0.47672538
75	Cholinergic synapse_Homo sapiens_hsa04725	0.47170420
76	Axon guidance_Homo sapiens_hsa04360	0.46791324
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.46228508
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46072008
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.45382164
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44718554
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43378640
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43058545
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42736447
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40155150
85	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.39351547
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36316371
87	Salivary secretion_Homo sapiens_hsa04970	0.36134317
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36123749
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35994130
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.34641075
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32158394
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31948117
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.30550303
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30257545
95	Gastric acid secretion_Homo sapiens_hsa04971	0.29035997
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29030470
97	Retinol metabolism_Homo sapiens_hsa00830	0.28281649
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.27281783
99	Fatty acid degradation_Homo sapiens_hsa00071	0.26454730
100	Pancreatic secretion_Homo sapiens_hsa04972	0.26343651

RPS8P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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