RPS8P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.61289652
2behavioral response to nicotine (GO:0035095)4.94691551
3somite development (GO:0061053)4.91222995
4viral transcription (GO:0019083)4.83797418
5translational termination (GO:0006415)4.68449674
6negative regulation of transcription regulatory region DNA binding (GO:2000678)4.55027466
7base-excision repair, AP site formation (GO:0006285)4.51300905
8ribosomal small subunit assembly (GO:0000028)4.42151808
9ribosomal small subunit biogenesis (GO:0042274)4.31562623
10neuron fate determination (GO:0048664)4.18309176
11dentate gyrus development (GO:0021542)4.15458797
12dopaminergic neuron differentiation (GO:0071542)4.12020867
13chaperone-mediated protein transport (GO:0072321)4.11587645
14ATP synthesis coupled proton transport (GO:0015986)4.02842828
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02842828
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89944725
17translational elongation (GO:0006414)3.87358510
18maturation of SSU-rRNA (GO:0030490)3.81250441
19cotranslational protein targeting to membrane (GO:0006613)3.79179380
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78579146
21regulation of cilium movement (GO:0003352)3.78529202
22protein targeting to ER (GO:0045047)3.73326775
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72951583
24substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.61407834
25substrate-independent telencephalic tangential migration (GO:0021826)3.61407834
26cellular protein complex disassembly (GO:0043624)3.59382618
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56774749
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.56774749
29NADH dehydrogenase complex assembly (GO:0010257)3.56774749
30protein complex biogenesis (GO:0070271)3.55697267
31protein localization to endoplasmic reticulum (GO:0070972)3.54210759
32auditory receptor cell differentiation (GO:0042491)3.47062274
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45811959
34viral life cycle (GO:0019058)3.44073011
35axonemal dynein complex assembly (GO:0070286)3.43812825
36cell proliferation in forebrain (GO:0021846)3.32851044
37detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.30238818
38detection of temperature stimulus involved in sensory perception (GO:0050961)3.30238818
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28841299
40regulation of microtubule-based movement (GO:0060632)3.24597240
41positive regulation of neuroblast proliferation (GO:0002052)3.21891881
42mitochondrial respiratory chain complex assembly (GO:0033108)3.18148282
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15220355
44water-soluble vitamin biosynthetic process (GO:0042364)3.14006646
45intraciliary transport (GO:0042073)3.10675909
46GTP biosynthetic process (GO:0006183)3.10580490
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06070204
48protein complex disassembly (GO:0043241)3.04294807
49postsynaptic membrane organization (GO:0001941)3.03483504
50tongue development (GO:0043586)2.94054416
51radial glial cell differentiation (GO:0060019)2.92775187
52pattern specification involved in kidney development (GO:0061004)2.91595445
53macromolecular complex disassembly (GO:0032984)2.88630036
54intracellular protein transmembrane import (GO:0044743)2.88256793
55myoblast migration (GO:0051451)2.84389453
56pyrimidine nucleotide catabolic process (GO:0006244)2.83970988
57retinal ganglion cell axon guidance (GO:0031290)2.83403824
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83155271
59telencephalon development (GO:0021537)2.80587729
60negative regulation of appetite (GO:0032099)2.79350203
61negative regulation of response to food (GO:0032096)2.79350203
62heart valve formation (GO:0003188)2.78921583
63DNA deamination (GO:0045006)2.78128405
64ganglion development (GO:0061548)2.77612030
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77538060
66regulation of catecholamine metabolic process (GO:0042069)2.75605396
67regulation of dopamine metabolic process (GO:0042053)2.75605396
68epithelial cilium movement (GO:0003351)2.71985867
69protein polyglutamylation (GO:0018095)2.69319950
70pyrimidine nucleobase catabolic process (GO:0006208)2.68759869
71neuron recognition (GO:0008038)2.68546126
72presynaptic membrane assembly (GO:0097105)2.67953466
73translational initiation (GO:0006413)2.67545857
74spinal cord development (GO:0021510)2.66985138
75platelet dense granule organization (GO:0060155)2.64176196
76ubiquinone metabolic process (GO:0006743)2.63141294
77mechanosensory behavior (GO:0007638)2.62550809
78nephron tubule morphogenesis (GO:0072078)2.61626574
79nephron epithelium morphogenesis (GO:0072088)2.61626574
80regulation of neuroblast proliferation (GO:1902692)2.61483335
81positive regulation of gastrulation (GO:2000543)2.61317393
82behavioral defense response (GO:0002209)2.60711575
83behavioral fear response (GO:0001662)2.60711575
84cerebral cortex radially oriented cell migration (GO:0021799)2.56302264
85UTP metabolic process (GO:0046051)2.56301986
86axon extension (GO:0048675)2.55158738
87axonal fasciculation (GO:0007413)2.52947141
88thalamus development (GO:0021794)2.52461749
89protein targeting to membrane (GO:0006612)2.51575581
90adaptation of signaling pathway (GO:0023058)2.51428510
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50853692
92neuronal stem cell maintenance (GO:0097150)2.49497210
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.48438034
94ubiquinone biosynthetic process (GO:0006744)2.48242658
95smoothened signaling pathway (GO:0007224)2.48153295
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.48107753
97synaptic transmission, cholinergic (GO:0007271)2.47961248
98epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47715585
99regulation of transcription regulatory region DNA binding (GO:2000677)2.47259878
100detection of temperature stimulus (GO:0016048)2.46989607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.15365799
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.89702847
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.86870537
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.92008350
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.21080817
6CBX2_27304074_Chip-Seq_ESCs_Mouse3.00969240
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83974335
8VDR_22108803_ChIP-Seq_LS180_Human2.72764485
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59299310
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.38889722
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38063013
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.28783490
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14801658
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14773281
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14394396
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10705686
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.05949605
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01641662
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01641662
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01423827
21RNF2_27304074_Chip-Seq_NSC_Mouse2.00092984
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99963877
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98042998
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.96821242
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88575532
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.87759161
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86568228
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.86428955
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79813498
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73530096
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.62655794
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57324912
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56837343
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56773330
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.55119575
36MYC_18940864_ChIP-ChIP_HL60_Human1.54394185
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53815913
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50319716
39REST_21632747_ChIP-Seq_MESCs_Mouse1.44862736
40EWS_26573619_Chip-Seq_HEK293_Human1.43858658
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43503933
42XRN2_22483619_ChIP-Seq_HELA_Human1.42825908
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42198505
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38374321
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36470331
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.35958467
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.35347054
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33755362
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30507088
50NANOG_20526341_ChIP-Seq_ESCs_Human1.29063207
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28928246
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27939639
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26116008
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20150885
55TP53_22573176_ChIP-Seq_HFKS_Human1.18142313
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16600175
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15896555
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15896555
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13276582
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13264506
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.13023607
62ERA_21632823_ChIP-Seq_H3396_Human1.12797918
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.08932949
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07766491
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.04161036
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03849175
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01873169
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00948754
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00866873
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00024509
71AR_21572438_ChIP-Seq_LNCaP_Human0.99233969
72ELK1_19687146_ChIP-ChIP_HELA_Human0.98986970
73NOTCH1_21737748_ChIP-Seq_TLL_Human0.98514488
74REST_18959480_ChIP-ChIP_MESCs_Mouse0.97868605
75CTCF_27219007_Chip-Seq_Bcells_Human0.97490943
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96021749
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95589483
78TTF2_22483619_ChIP-Seq_HELA_Human0.94342759
79P300_19829295_ChIP-Seq_ESCs_Human0.93450505
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92830506
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92543449
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92515385
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92324178
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.91717816
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90866832
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87790055
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85313325
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85002619
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.84063549
90IRF1_19129219_ChIP-ChIP_H3396_Human0.82427952
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81896484
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.81458276
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81223295
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80901417
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80308904
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79327194
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77997356
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77993703
99TAF2_19829295_ChIP-Seq_ESCs_Human0.76786308
100FUS_26573619_Chip-Seq_HEK293_Human0.76537161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.55098681
2MP0002822_catalepsy4.23471325
3MP0006292_abnormal_olfactory_placode4.03290938
4MP0010030_abnormal_orbit_morphology3.26573478
5MP0000566_synostosis3.10213624
6MP0004145_abnormal_muscle_electrophysio3.09050045
7MP0002938_white_spotting2.90620688
8MP0008789_abnormal_olfactory_epithelium2.68306379
9MP0003880_abnormal_central_pattern2.37606995
10MP0001485_abnormal_pinna_reflex2.32222995
11MP0002234_abnormal_pharynx_morphology2.16348922
12MP0000778_abnormal_nervous_system2.10612855
13MP0003123_paternal_imprinting2.08019639
14MP0005394_taste/olfaction_phenotype2.00501011
15MP0005499_abnormal_olfactory_system2.00501011
16MP0000049_abnormal_middle_ear1.96256429
17MP0004742_abnormal_vestibular_system1.94953718
18MP0001529_abnormal_vocalization1.94916056
19MP0003938_abnormal_ear_development1.81107241
20MP0004885_abnormal_endolymph1.78083547
21MP0002163_abnormal_gland_morphology1.76463673
22MP0002733_abnormal_thermal_nociception1.74463688
23MP0003787_abnormal_imprinting1.74446245
24MP0001905_abnormal_dopamine_level1.68504398
25MP0000631_abnormal_neuroendocrine_gland1.59268023
26MP0000026_abnormal_inner_ear1.56699077
27MP0005551_abnormal_eye_electrophysiolog1.56466854
28MP0002653_abnormal_ependyma_morphology1.55845402
29MP0009745_abnormal_behavioral_response1.52650445
30MP0003878_abnormal_ear_physiology1.48008341
31MP0005377_hearing/vestibular/ear_phenot1.48008341
32MP0003119_abnormal_digestive_system1.47133227
33MP0001293_anophthalmia1.45729952
34MP0009053_abnormal_anal_canal1.42861965
35MP0002557_abnormal_social/conspecific_i1.42810444
36MP0001879_abnormal_lymphatic_vessel1.39205934
37MP0002184_abnormal_innervation1.38617905
38MP0004142_abnormal_muscle_tone1.37916141
39MP0003121_genomic_imprinting1.36049214
40MP0002102_abnormal_ear_morphology1.34964806
41MP0001970_abnormal_pain_threshold1.34766611
42MP0005174_abnormal_tail_pigmentation1.31956134
43MP0006276_abnormal_autonomic_nervous1.30870691
44MP0002272_abnormal_nervous_system1.27986672
45MP0003635_abnormal_synaptic_transmissio1.26303991
46MP0006072_abnormal_retinal_apoptosis1.25918099
47MP0002572_abnormal_emotion/affect_behav1.25403998
48MP0002736_abnormal_nociception_after1.24745440
49MP0004133_heterotaxia1.24093481
50MP0002233_abnormal_nose_morphology1.21407894
51MP0005085_abnormal_gallbladder_physiolo1.20019904
52MP0001486_abnormal_startle_reflex1.19176809
53MP0003136_yellow_coat_color1.18900130
54MP0005367_renal/urinary_system_phenotyp1.18577700
55MP0000516_abnormal_urinary_system1.18577700
56MP0005195_abnormal_posterior_eye1.17582590
57MP0008875_abnormal_xenobiotic_pharmacok1.16578592
58MP0001968_abnormal_touch/_nociception1.15322138
59MP0005423_abnormal_somatic_nervous1.13387715
60MP0008872_abnormal_physiological_respon1.12002439
61MP0003942_abnormal_urinary_system1.09769607
62MP0000955_abnormal_spinal_cord1.08513944
63MP0002837_dystrophic_cardiac_calcinosis1.07189211
64MP0002752_abnormal_somatic_nervous1.06972140
65MP0002063_abnormal_learning/memory/cond1.06926891
66MP0001986_abnormal_taste_sensitivity1.05658800
67MP0000372_irregular_coat_pigmentation1.03432498
68MP0004147_increased_porphyrin_level1.03118745
69MP0004859_abnormal_synaptic_plasticity1.02545681
70MP0008877_abnormal_DNA_methylation1.01626170
71MP0003937_abnormal_limbs/digits/tail_de1.01464082
72MP0001963_abnormal_hearing_physiology1.00746775
73MP0008775_abnormal_heart_ventricle0.99717218
74MP0010368_abnormal_lymphatic_system0.99013761
75MP0002067_abnormal_sensory_capabilities0.92919154
76MP0003755_abnormal_palate_morphology0.92469564
77MP0002249_abnormal_larynx_morphology0.91483815
78MP0001348_abnormal_lacrimal_gland0.91479933
79MP0003861_abnormal_nervous_system0.90296227
80MP0002095_abnormal_skin_pigmentation0.89405954
81MP0003879_abnormal_hair_cell0.88878221
82MP0000427_abnormal_hair_cycle0.87502450
83MP0003137_abnormal_impulse_conducting0.86633995
84MP0002928_abnormal_bile_duct0.86627484
85MP0001919_abnormal_reproductive_system0.84993177
86MP0002116_abnormal_craniofacial_bone0.81924602
87MP0004811_abnormal_neuron_physiology0.80999934
88MP0000537_abnormal_urethra_morphology0.79721067
89MP0002882_abnormal_neuron_morphology0.79310808
90MP0000534_abnormal_ureter_morphology0.78438777
91MP0002160_abnormal_reproductive_system0.77241734
92MP0000750_abnormal_muscle_regeneration0.75465513
93MP0002152_abnormal_brain_morphology0.75397968
94MP0001873_stomach_inflammation0.75233796
95MP0009384_cardiac_valve_regurgitation0.74922942
96MP0005389_reproductive_system_phenotype0.74396217
97MP0009250_abnormal_appendicular_skeleto0.72199789
98MP0000230_abnormal_systemic_arterial0.71606009
99MP0001286_abnormal_eye_development0.71044285
100MP0005646_abnormal_pituitary_gland0.70588258

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.20935462
2Congenital, generalized hypertrichosis (HP:0004540)3.85888491
3Septo-optic dysplasia (HP:0100842)3.56273935
4True hermaphroditism (HP:0010459)3.49910999
5Nephronophthisis (HP:0000090)3.25234310
6Sclerocornea (HP:0000647)3.11523442
7Pancreatic fibrosis (HP:0100732)3.10311326
8Anophthalmia (HP:0000528)3.03577036
9Abnormal respiratory motile cilium morphology (HP:0005938)2.97636775
10Abnormal respiratory epithelium morphology (HP:0012253)2.97636775
11Hyperventilation (HP:0002883)2.96333570
12Reticulocytopenia (HP:0001896)2.92748718
13Acute necrotizing encephalopathy (HP:0006965)2.91223444
14Mitochondrial inheritance (HP:0001427)2.86112428
15Pancreatic cysts (HP:0001737)2.78264254
16Maternal diabetes (HP:0009800)2.76616351
17Molar tooth sign on MRI (HP:0002419)2.75984733
18Abnormality of midbrain morphology (HP:0002418)2.75984733
19Constricted visual fields (HP:0001133)2.73015682
20Aplasia/Hypoplasia of the spleen (HP:0010451)2.71498837
21Abnormality of the renal medulla (HP:0100957)2.69990891
22Hemiparesis (HP:0001269)2.67612743
23Asplenia (HP:0001746)2.67388082
2411 pairs of ribs (HP:0000878)2.64418555
25Abnormal respiratory motile cilium physiology (HP:0012261)2.63758039
26Congenital stationary night blindness (HP:0007642)2.56811426
27Anencephaly (HP:0002323)2.54205284
28Myokymia (HP:0002411)2.53870875
29Abnormal ciliary motility (HP:0012262)2.52947391
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49348752
31Abnormal mitochondria in muscle tissue (HP:0008316)2.46448491
32Chorioretinal atrophy (HP:0000533)2.45690018
33Acute encephalopathy (HP:0006846)2.44453287
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.43584883
35Agitation (HP:0000713)2.43577934
36Increased hepatocellular lipid droplets (HP:0006565)2.41373431
37Polyphagia (HP:0002591)2.38421025
38Abnormal rod and cone electroretinograms (HP:0008323)2.36678377
39Oligodactyly (hands) (HP:0001180)2.33964980
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33459619
41Adrenal hypoplasia (HP:0000835)2.30079878
42Stenosis of the external auditory canal (HP:0000402)2.29803865
43Increased CSF lactate (HP:0002490)2.29144138
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28898483
45Gait imbalance (HP:0002141)2.28744723
46Type II lissencephaly (HP:0007260)2.27944379
47Pachygyria (HP:0001302)2.27868888
48Palpebral edema (HP:0100540)2.25325585
49Large for gestational age (HP:0001520)2.25252980
50Polyuria (HP:0000103)2.24089075
51Lipid accumulation in hepatocytes (HP:0006561)2.23218326
52Bilateral microphthalmos (HP:0007633)2.21522877
53Pendular nystagmus (HP:0012043)2.20925888
54Amblyopia (HP:0000646)2.20422348
55Progressive macrocephaly (HP:0004481)2.18891527
56Concave nail (HP:0001598)2.17884089
57Fibular hypoplasia (HP:0003038)2.17737883
58Postaxial foot polydactyly (HP:0001830)2.16785709
59Exertional dyspnea (HP:0002875)2.16109532
60Hypoplastic pelvis (HP:0008839)2.14416874
61Supernumerary spleens (HP:0009799)2.11196800
62Medial flaring of the eyebrow (HP:0010747)2.11072614
63Epileptic encephalopathy (HP:0200134)2.10686324
64Absent septum pellucidum (HP:0001331)2.10362224
65Abnormality of cells of the erythroid lineage (HP:0012130)2.08955019
66Optic nerve hypoplasia (HP:0000609)2.08881377
67Macrocytic anemia (HP:0001972)2.07835520
68Oligodactyly (HP:0012165)2.05622664
69Limb dystonia (HP:0002451)2.04746468
70Abnormality of the diencephalon (HP:0010662)2.02291603
71Absent/shortened dynein arms (HP:0200106)2.01014880
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.01014880
73Cystic liver disease (HP:0006706)2.00888391
74Down-sloping shoulders (HP:0200021)1.94590505
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93644668
76Pigmentary retinal degeneration (HP:0001146)1.91472335
77Rib fusion (HP:0000902)1.91447424
78Holoprosencephaly (HP:0001360)1.90203664
79Porencephaly (HP:0002132)1.89241505
80Optic disc pallor (HP:0000543)1.89047490
81Progressive microcephaly (HP:0000253)1.88882825
823-Methylglutaconic aciduria (HP:0003535)1.86341596
83Optic nerve coloboma (HP:0000588)1.86297436
84Opisthotonus (HP:0002179)1.85191024
85Renal dysplasia (HP:0000110)1.83196683
86Anterior segment dysgenesis (HP:0007700)1.81761698
87Congenital malformation of the right heart (HP:0011723)1.81242633
88Double outlet right ventricle (HP:0001719)1.81242633
89Short tibia (HP:0005736)1.80025393
90Hypoplasia of the ulna (HP:0003022)1.79829121
91Renal Fanconi syndrome (HP:0001994)1.79239628
92Aplasia/Hypoplasia of the fibula (HP:0006492)1.79158771
93Esophageal atresia (HP:0002032)1.78138193
94Polydipsia (HP:0001959)1.77285011
95Abnormal drinking behavior (HP:0030082)1.77285011
96Rhinitis (HP:0012384)1.76169544
97Abnormal urine output (HP:0012590)1.74707379
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73803994
99Short 4th metacarpal (HP:0010044)1.73803994
100Preaxial hand polydactyly (HP:0001177)1.73587532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.33030493
2STK164.20371754
3CASK3.80586749
4TAF13.56554934
5MAPK153.12677579
6PNCK3.08583033
7NUAK12.61746888
8MARK12.50079863
9DYRK22.44891114
10MAPK132.43603068
11MAP3K102.35357123
12PHKG22.10798442
13PHKG12.10798442
14VRK12.07201454
15WNK32.01352419
16WNK41.75891412
17PRKD31.66648310
18ADRBK21.64553877
19EPHB21.63683043
20BMPR1B1.56548969
21CDC71.50201732
22CDK81.49260215
23NTRK31.45455214
24DYRK1B1.43852975
25EIF2AK21.41289376
26PAK31.36834336
27NEK11.24675859
28CAMKK21.23366652
29CSNK1G21.20449770
30TIE11.20171825
31NTRK21.18505479
32TNIK1.14395367
33EPHA31.11832010
34STK38L1.11479054
35WEE11.02949995
36ABL21.00849410
37MAP2K71.00775794
38DAPK21.00559520
39PIK3CA1.00036598
40CSNK1G30.98462067
41GRK50.97566085
42TAOK30.94777903
43CSNK1A1L0.94631067
44MKNK20.92497933
45TLK10.88090218
46SMG10.88033456
47PKN10.87684134
48PRKCG0.86994758
49CHEK20.79912811
50CSNK1G10.79090400
51BCKDK0.78466799
52PAK60.77476946
53PRKCI0.76696004
54NME10.76363751
55GRK10.70968621
56MAP2K20.70376686
57MAPKAPK50.69372202
58PLK40.69263755
59TXK0.65687329
60ADRBK10.64504346
61CAMK10.59552831
62MAPK120.59529859
63TSSK60.55595966
64WNK10.55530400
65MINK10.55037552
66SRPK10.54861293
67NME20.52153741
68PLK30.51004610
69DYRK1A0.50811570
70STK390.49111683
71AURKA0.48839580
72DAPK30.48753857
73NLK0.48214132
74LIMK10.48153257
75GSK3A0.47684273
76MST40.47021352
77DAPK10.46058514
78EPHA40.42104915
79CCNB10.41099523
80CDK190.39708814
81ATR0.38054035
82PRKCE0.36286147
83RPS6KA40.36285905
84TRIB30.35104701
85MAP4K20.34949942
86CDK30.34113410
87MUSK0.32102070
88TGFBR10.31628557
89MARK20.31229882
90CDK50.30982984
91HIPK20.29712375
92BRAF0.29144918
93CDK11A0.28839722
94ILK0.27796661
95CAMK1D0.27624092
96RPS6KA50.27470635
97CAMK2A0.26932729
98OBSCN0.26905761
99CAMKK10.26905685
100STK30.26561620

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.52690145
2Oxidative phosphorylation_Homo sapiens_hsa001903.88868803
3Parkinsons disease_Homo sapiens_hsa050122.96177149
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.82689155
5Cardiac muscle contraction_Homo sapiens_hsa042602.53515130
6Alzheimers disease_Homo sapiens_hsa050102.41860022
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31858120
8Huntingtons disease_Homo sapiens_hsa050162.23571679
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20437794
10Collecting duct acid secretion_Homo sapiens_hsa049662.15202108
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11815241
12Steroid biosynthesis_Homo sapiens_hsa001002.11449667
13Protein export_Homo sapiens_hsa030602.10264598
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92674187
15RNA polymerase_Homo sapiens_hsa030201.84542380
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83243815
17Nicotine addiction_Homo sapiens_hsa050331.77073882
18Proteasome_Homo sapiens_hsa030501.63903301
19Selenocompound metabolism_Homo sapiens_hsa004501.61395895
20Phototransduction_Homo sapiens_hsa047441.61195365
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55443241
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45841983
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44994498
24Asthma_Homo sapiens_hsa053101.44255407
25Hedgehog signaling pathway_Homo sapiens_hsa043401.37626585
26Homologous recombination_Homo sapiens_hsa034401.35704227
27Nucleotide excision repair_Homo sapiens_hsa034201.33793914
28Basal cell carcinoma_Homo sapiens_hsa052171.32279274
29Linoleic acid metabolism_Homo sapiens_hsa005911.31144391
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29763953
31Basal transcription factors_Homo sapiens_hsa030221.28051757
32Morphine addiction_Homo sapiens_hsa050321.27191063
33Vitamin B6 metabolism_Homo sapiens_hsa007501.19095793
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.10012739
35Fanconi anemia pathway_Homo sapiens_hsa034601.09486831
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.94414640
37Notch signaling pathway_Homo sapiens_hsa043300.91289277
38Peroxisome_Homo sapiens_hsa041460.88833007
39RNA degradation_Homo sapiens_hsa030180.88314954
40Regulation of autophagy_Homo sapiens_hsa041400.85688785
41Sulfur relay system_Homo sapiens_hsa041220.84564378
42Oxytocin signaling pathway_Homo sapiens_hsa049210.78257871
43Spliceosome_Homo sapiens_hsa030400.77828390
44GABAergic synapse_Homo sapiens_hsa047270.77342137
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.74389059
46Pyrimidine metabolism_Homo sapiens_hsa002400.74342750
47Cholinergic synapse_Homo sapiens_hsa047250.74235582
48Salivary secretion_Homo sapiens_hsa049700.73670426
49Cocaine addiction_Homo sapiens_hsa050300.71607768
50Axon guidance_Homo sapiens_hsa043600.71418179
51Caffeine metabolism_Homo sapiens_hsa002320.69714482
52Arachidonic acid metabolism_Homo sapiens_hsa005900.69042469
53Purine metabolism_Homo sapiens_hsa002300.68816750
54Base excision repair_Homo sapiens_hsa034100.66245118
55Mismatch repair_Homo sapiens_hsa034300.65919511
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64442681
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.64199244
58Circadian entrainment_Homo sapiens_hsa047130.62601565
59Insulin secretion_Homo sapiens_hsa049110.62584749
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.61318122
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60705325
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.59826078
63Renin secretion_Homo sapiens_hsa049240.57452431
64Olfactory transduction_Homo sapiens_hsa047400.54638584
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54073017
66Long-term depression_Homo sapiens_hsa047300.53807836
67DNA replication_Homo sapiens_hsa030300.53448631
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.51096133
69Butanoate metabolism_Homo sapiens_hsa006500.50642182
70Chemical carcinogenesis_Homo sapiens_hsa052040.50557123
71Wnt signaling pathway_Homo sapiens_hsa043100.49651506
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49115730
73Metabolic pathways_Homo sapiens_hsa011000.48973748
74Dopaminergic synapse_Homo sapiens_hsa047280.47727441
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47072485
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46894610
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44549983
78Glutamatergic synapse_Homo sapiens_hsa047240.44124698
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43129461
80Tryptophan metabolism_Homo sapiens_hsa003800.42472898
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40993716
82Gastric acid secretion_Homo sapiens_hsa049710.40809778
83Taste transduction_Homo sapiens_hsa047420.40392121
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39136943
85Dilated cardiomyopathy_Homo sapiens_hsa054140.38868622
86cAMP signaling pathway_Homo sapiens_hsa040240.37288298
87Serotonergic synapse_Homo sapiens_hsa047260.36706030
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35765539
89Dorso-ventral axis formation_Homo sapiens_hsa043200.34787197
90Fat digestion and absorption_Homo sapiens_hsa049750.33722214
91Calcium signaling pathway_Homo sapiens_hsa040200.33701674
92Amphetamine addiction_Homo sapiens_hsa050310.30609479
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30392269
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30121870
95Retinol metabolism_Homo sapiens_hsa008300.30091811
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29487471
97Nitrogen metabolism_Homo sapiens_hsa009100.29301621
98Hippo signaling pathway_Homo sapiens_hsa043900.29226808
99Autoimmune thyroid disease_Homo sapiens_hsa053200.28746431
100Glutathione metabolism_Homo sapiens_hsa004800.28148208

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