RPS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.55947288
2* viral transcription (GO:0019083)8.36076814
3* translational termination (GO:0006415)8.01000598
4ribosomal small subunit biogenesis (GO:0042274)7.50591567
5* translational elongation (GO:0006414)6.92494374
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.82878889
7* cotranslational protein targeting to membrane (GO:0006613)6.69913321
8* protein targeting to ER (GO:0045047)6.68548080
9maturation of SSU-rRNA (GO:0030490)6.39168860
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.37998995
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.31538182
12* protein localization to endoplasmic reticulum (GO:0070972)6.25376635
13* viral life cycle (GO:0019058)6.24635065
14* cellular protein complex disassembly (GO:0043624)6.17451568
15* translational initiation (GO:0006413)5.97496077
16* protein complex disassembly (GO:0043241)5.47807141
17ribosomal large subunit biogenesis (GO:0042273)5.35269958
18* macromolecular complex disassembly (GO:0032984)5.09742452
19* nuclear-transcribed mRNA catabolic process (GO:0000956)4.61465896
20* protein targeting to membrane (GO:0006612)4.42542389
21* mRNA catabolic process (GO:0006402)4.38621480
22* translation (GO:0006412)4.27542299
23ribonucleoprotein complex biogenesis (GO:0022613)4.26461027
24formation of translation preinitiation complex (GO:0001731)4.15400661
25* RNA catabolic process (GO:0006401)4.12136279
26DNA deamination (GO:0045006)3.90748088
27DNA strand elongation involved in DNA replication (GO:0006271)3.81243100
28telomere maintenance via semi-conservative replication (GO:0032201)3.67542130
29DNA strand elongation (GO:0022616)3.63389207
30DNA unwinding involved in DNA replication (GO:0006268)3.54039555
31negative regulation of erythrocyte differentiation (GO:0045647)3.52497077
32rRNA processing (GO:0006364)3.47163487
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39837048
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.39837048
35modulation by symbiont of host immune response (GO:0052553)3.39837048
36positive regulation by symbiont of host defense response (GO:0052509)3.39837048
37modulation by symbiont of host defense response (GO:0052031)3.39837048
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39837048
39rRNA metabolic process (GO:0016072)3.33688129
40telomere maintenance via recombination (GO:0000722)3.19782318
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14777410
42cellular component biogenesis (GO:0044085)3.14251017
43NIK/NF-kappaB signaling (GO:0038061)3.12797056
44DNA replication initiation (GO:0006270)3.10803178
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04508464
46negative regulation of cell killing (GO:0031342)3.04508464
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02804651
48mitotic recombination (GO:0006312)2.96059188
49* establishment of protein localization to membrane (GO:0090150)2.95480058
50negative regulation of RNA splicing (GO:0033119)2.95263982
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95190034
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95190034
53modulation by virus of host process (GO:0019054)2.93654419
54establishment of integrated proviral latency (GO:0075713)2.92456879
55ncRNA 3-end processing (GO:0043628)2.89612509
56positive thymic T cell selection (GO:0045059)2.87919847
57nucleotide-excision repair, DNA gap filling (GO:0006297)2.83860387
583-UTR-mediated mRNA stabilization (GO:0070935)2.83546989
59telomere maintenance via telomere lengthening (GO:0010833)2.82236284
60modulation by symbiont of host cellular process (GO:0044068)2.82230383
61response to peptidoglycan (GO:0032494)2.81947915
62thymic T cell selection (GO:0045061)2.78876329
63myeloid cell homeostasis (GO:0002262)2.78749436
64activation of MAPKKK activity (GO:0000185)2.73186669
65* establishment of protein localization to organelle (GO:0072594)2.70945200
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70219741
67antigen processing and presentation of endogenous antigen (GO:0019883)2.70052370
68spliceosomal snRNP assembly (GO:0000387)2.69212243
69* protein targeting (GO:0006605)2.68839589
70ribosome biogenesis (GO:0042254)2.65248928
71regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64885456
72pinocytosis (GO:0006907)2.64124296
73* protein localization to membrane (GO:0072657)2.63003694
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62656221
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60379553
76nucleobase biosynthetic process (GO:0046112)2.60276486
77detection of bacterium (GO:0016045)2.58845896
78apoptotic process involved in morphogenesis (GO:0060561)2.58250050
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57869850
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57675998
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56100091
82pseudouridine synthesis (GO:0001522)2.55801502
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55499588
84response to muramyl dipeptide (GO:0032495)2.54736133
85positive regulation of T cell apoptotic process (GO:0070234)2.54477826
86negative regulation of ligase activity (GO:0051352)2.54000093
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54000093
88cellular response to virus (GO:0098586)2.53672809
89immunoglobulin mediated immune response (GO:0016064)2.53086232
90leukocyte aggregation (GO:0070486)2.53025155
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52077276
92transcription-coupled nucleotide-excision repair (GO:0006283)2.51596372
93spliceosomal complex assembly (GO:0000245)2.50088436
94regulation of protein heterodimerization activity (GO:0043497)2.49153307
95protein localization to kinetochore (GO:0034501)2.48391501
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48314687
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48314687
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.47974283
99negative regulation of DNA-templated transcription, elongation (GO:0032785)2.47864543
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47358233
101detection of other organism (GO:0098543)2.46815574
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46804243
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45967691
104transcription elongation from RNA polymerase III promoter (GO:0006385)2.45888962
105termination of RNA polymerase III transcription (GO:0006386)2.45888962
106IMP biosynthetic process (GO:0006188)2.45113029
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45108863
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45108863
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45108863
110mRNA splicing, via spliceosome (GO:0000398)2.44433508
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.44433508
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44341543
113pentose-phosphate shunt (GO:0006098)2.44134358
114ncRNA processing (GO:0034470)2.43973896
115RNA splicing, via transesterification reactions (GO:0000375)2.43810636
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43117638
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.42706206
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.42706206
119proteasome assembly (GO:0043248)2.41653611
120CENP-A containing nucleosome assembly (GO:0034080)2.41301307
121establishment of viral latency (GO:0019043)2.41017894
122positive regulation of gamma-delta T cell activation (GO:0046645)2.40611532
123* gene expression (GO:0010467)2.40305373
124regulation of gamma-delta T cell activation (GO:0046643)2.39974350
125positive regulation of lymphocyte apoptotic process (GO:0070230)2.39645331
126mannose metabolic process (GO:0006013)2.38848161
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.38556298
128negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37815933
129pentose metabolic process (GO:0019321)2.36774075
130termination of RNA polymerase II transcription (GO:0006369)2.35830969
131negative regulation of interleukin-12 production (GO:0032695)2.35647472
132respiratory burst (GO:0045730)2.35507537
133lymphocyte apoptotic process (GO:0070227)2.35460310
134positive regulation of B cell differentiation (GO:0045579)2.34912579
135DNA replication checkpoint (GO:0000076)2.34148536
136chromatin remodeling at centromere (GO:0031055)2.34119007
137viral protein processing (GO:0019082)2.34016564
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.33395224
139viral mRNA export from host cell nucleus (GO:0046784)2.33043906
140T cell apoptotic process (GO:0070231)2.32995308
141heterochromatin organization (GO:0070828)2.32754244
142histone mRNA metabolic process (GO:0008334)2.31627231
143T cell selection (GO:0045058)2.29810337
144leukocyte apoptotic process (GO:0071887)2.29332975
145positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.29162026
146B cell receptor signaling pathway (GO:0050853)2.28816994
147ribonucleoprotein complex assembly (GO:0022618)2.28693516
148ribosome assembly (GO:0042255)2.28331723
149DNA replication-independent nucleosome assembly (GO:0006336)2.28268652
150DNA replication-independent nucleosome organization (GO:0034724)2.28268652
151IMP metabolic process (GO:0046040)2.27130814
152* cellular component disassembly (GO:0022411)2.26975406
153negative thymic T cell selection (GO:0045060)2.26724232
154regulation of interleukin-2 biosynthetic process (GO:0045076)2.26076458
155negative regulation of innate immune response (GO:0045824)2.25949986
156GDP-mannose metabolic process (GO:0019673)2.25273171
157myeloid dendritic cell differentiation (GO:0043011)2.24169060
158T cell migration (GO:0072678)2.22838521
159regulation of superoxide anion generation (GO:0032928)2.21167462
160regulation of dendritic cell antigen processing and presentation (GO:0002604)2.20524262
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.18679783
162peptidyl-arginine omega-N-methylation (GO:0035247)2.18475920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.29540235
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.11051662
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86223157
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68433520
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97900511
6* EST1_17652178_ChIP-ChIP_JURKAT_Human2.89429205
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.86486438
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77194677
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66328080
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.66122774
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60157351
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52024057
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.51805511
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50106799
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48736506
16* XRN2_22483619_ChIP-Seq_HELA_Human2.46340214
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40479060
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39830787
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35740488
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33920253
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33645345
22* VDR_23849224_ChIP-Seq_CD4+_Human2.20888243
23MYC_22102868_ChIP-Seq_BL_Human2.20625967
24LXR_22292898_ChIP-Seq_THP-1_Human2.20612529
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.17204932
26* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14861050
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02252693
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.01327797
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99427889
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95802325
31FOXP3_21729870_ChIP-Seq_TREG_Human1.94863918
32* TTF2_22483619_ChIP-Seq_HELA_Human1.91065494
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86627005
34* VDR_21846776_ChIP-Seq_THP-1_Human1.86443476
35DCP1A_22483619_ChIP-Seq_HELA_Human1.82172967
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78846347
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77375967
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76489730
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.75540977
40ELK1_19687146_ChIP-ChIP_HELA_Human1.75506102
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75349358
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74726153
43CIITA_25753668_ChIP-Seq_RAJI_Human1.73720596
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68626033
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68169017
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65903408
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.63400355
48TCF7_22412390_ChIP-Seq_EML_Mouse1.60555540
49KDM2B_26808549_Chip-Seq_DND41_Human1.59413173
50GABP_19822575_ChIP-Seq_HepG2_Human1.58841723
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58680300
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58497702
53RACK7_27058665_Chip-Seq_MCF-7_Human1.58425369
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.54660942
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54541514
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53593321
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.52792685
58SPI1_23547873_ChIP-Seq_NB4_Human1.52527318
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50060536
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46196953
61SCL_19346495_ChIP-Seq_HPC-7_Human1.44494050
62P68_20966046_ChIP-Seq_HELA_Human1.44349505
63ZNF263_19887448_ChIP-Seq_K562_Human1.42969809
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42945314
65* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42839388
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41783663
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40186863
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39821838
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38499540
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.37581752
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.37159723
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.36169797
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35412417
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.31849888
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30166314
76* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29803807
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29458108
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.29355462
79* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29192066
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.28990671
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28849815
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28023598
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27622113
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27155757
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.27045104
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26849426
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26086358
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23824640
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22262185
90* MAF_26560356_Chip-Seq_TH1_Human1.22059723
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21594776
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.20860689
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20458774
94MYB_26560356_Chip-Seq_TH2_Human1.18340980
95AR_21909140_ChIP-Seq_LNCAP_Human1.18293966
96UTX_26944678_Chip-Seq_JUKART_Human1.17128812
97* NCOR1_26117541_ChIP-Seq_K562_Human1.16651876
98BCOR_27268052_Chip-Seq_Bcells_Human1.16650731
99BCL6_27268052_Chip-Seq_Bcells_Human1.16139896
100KDM5A_27292631_Chip-Seq_BREAST_Human1.15788929
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.15399540
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14036996
103VDR_24763502_ChIP-Seq_THP-1_Human1.12895501
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12537092
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11938176
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11369465
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10287630
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10272093
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09441876
110* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09069054
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08854679
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08517103
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08218477
114MAF_26560356_Chip-Seq_TH2_Human1.07818849
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07156459
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.06648372
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06350074
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05990691
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05285369
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05114873
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04531708
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03706545
123MYB_26560356_Chip-Seq_TH1_Human1.03399492
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03268778
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02655836
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.02427507
127TFEB_21752829_ChIP-Seq_HELA_Human1.01540841
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.01010024
129* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00647371
130CTCF_21964334_Chip-Seq_Bcells_Human0.98860018
131SMC4_20622854_ChIP-Seq_HELA_Human0.98475049
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97576569
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96843806
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96392664
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95911349
136MYC_18940864_ChIP-ChIP_HL60_Human0.94900504
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94724630
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93501158
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92202878
140* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91306813
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90521182
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89069556
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88743940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.68855409
2MP0002396_abnormal_hematopoietic_system3.06793318
3MP0009379_abnormal_foot_pigmentation2.96922871
4MP0004957_abnormal_blastocyst_morpholog2.94407167
5MP0010094_abnormal_chromosome_stability2.71454075
6MP0003077_abnormal_cell_cycle2.67886267
7MP0001835_abnormal_antigen_presentation2.57522106
8MP0003763_abnormal_thymus_physiology2.51133474
9MP0003111_abnormal_nucleus_morphology2.44230228
10MP0008057_abnormal_DNA_replication2.32895217
11MP0000685_abnormal_immune_system2.30611138
12MP0003705_abnormal_hypodermis_morpholog2.29125049
13MP0009333_abnormal_splenocyte_physiolog2.25937075
14MP0005058_abnormal_lysosome_morphology2.25375657
15MP0000490_abnormal_crypts_of2.14004053
16MP0005451_abnormal_body_composition2.11665961
17MP0004808_abnormal_hematopoietic_stem2.04790138
18MP0008007_abnormal_cellular_replicative2.02246231
19MP0001800_abnormal_humoral_immune2.02018980
20MP0002398_abnormal_bone_marrow2.00327483
21MP0005671_abnormal_response_to1.96078302
22MP0008058_abnormal_DNA_repair1.91595254
23MP0009785_altered_susceptibility_to1.86928693
24MP0004185_abnormal_adipocyte_glucose1.83595127
25MP0002452_abnormal_antigen_presenting1.79149247
26MP0002420_abnormal_adaptive_immunity1.78445738
27MP0001819_abnormal_immune_cell1.75700930
28MP0002722_abnormal_immune_system1.74357545
29MP0000689_abnormal_spleen_morphology1.68982248
30MP0002723_abnormal_immune_serum1.67535685
31MP0010352_gastrointestinal_tract_polyps1.67273136
32MP0005397_hematopoietic_system_phenotyp1.67185239
33MP0001545_abnormal_hematopoietic_system1.67185239
34MP0005025_abnormal_response_to1.67059664
35MP0005000_abnormal_immune_tolerance1.66471536
36MP0000716_abnormal_immune_system1.65767033
37MP0000703_abnormal_thymus_morphology1.64816361
38MP0002166_altered_tumor_susceptibility1.63287428
39MP0005174_abnormal_tail_pigmentation1.59536893
40MP0009840_abnormal_foam_cell1.59472787
41MP0002429_abnormal_blood_cell1.59229753
42MP0000465_gastrointestinal_hemorrhage1.57986899
43MP0002148_abnormal_hypersensitivity_rea1.57012162
44MP0008932_abnormal_embryonic_tissue1.56174276
45MP0008260_abnormal_autophagy1.55830434
46MP0001790_abnormal_immune_system1.55076982
47MP0005387_immune_system_phenotype1.55076982
48MP0006054_spinal_hemorrhage1.54757544
49MP0002405_respiratory_system_inflammati1.52432640
50MP0003436_decreased_susceptibility_to1.51161042
51MP0010155_abnormal_intestine_physiology1.48381813
52MP0000350_abnormal_cell_proliferation1.44459966
53MP0001853_heart_inflammation1.43986504
54MP0002019_abnormal_tumor_incidence1.42052684
55MP0001873_stomach_inflammation1.41391923
56MP0002796_impaired_skin_barrier1.40556464
57MP0003866_abnormal_defecation1.35438608
58MP0005075_abnormal_melanosome_morpholog1.34452598
59MP0002132_abnormal_respiratory_system1.33952955
60MP0001730_embryonic_growth_arrest1.33438870
61MP0002006_tumorigenesis1.33227916
62MP0003786_premature_aging1.32488986
63MP0009278_abnormal_bone_marrow1.31915416
64MP0004858_abnormal_nervous_system1.27679347
65MP0000678_abnormal_parathyroid_gland1.26268287
66MP0003453_abnormal_keratinocyte_physiol1.24631265
67MP0001849_ear_inflammation1.22416001
68MP0005464_abnormal_platelet_physiology1.21641364
69MP0000313_abnormal_cell_death1.20854441
70MP0000858_altered_metastatic_potential1.20228548
71MP0002163_abnormal_gland_morphology1.19408170
72MP0002095_abnormal_skin_pigmentation1.18307900
73MP0005076_abnormal_cell_differentiation1.18296091
74MP0003567_abnormal_fetal_cardiomyocyte1.16760317
75MP0003191_abnormal_cellular_cholesterol1.15941199
76MP0002419_abnormal_innate_immunity1.14431996
77MP0006082_CNS_inflammation1.10587862
78MP0002998_abnormal_bone_remodeling1.04503901
79MP0003806_abnormal_nucleotide_metabolis1.04441978
80MP0005666_abnormal_adipose_tissue1.00743230
81MP0001845_abnormal_inflammatory_respons0.99099218
82MP0004947_skin_inflammation0.97979637
83MP0002080_prenatal_lethality0.97343377
84MP0003724_increased_susceptibility_to0.96448649
85MP0004510_myositis0.93423904
86MP0001697_abnormal_embryo_size0.92475103
87MP0002877_abnormal_melanocyte_morpholog0.92374002
88MP0010307_abnormal_tumor_latency0.92317251
89MP0002254_reproductive_system_inflammat0.91598902
90MP0002938_white_spotting0.90730196
91MP0000477_abnormal_intestine_morphology0.86978194
92MP0000750_abnormal_muscle_regeneration0.86687037
93MP0003315_abnormal_perineum_morphology0.85473090
94MP0003186_abnormal_redox_activity0.85336545
95MP0004381_abnormal_hair_follicle0.83695113
96MP0005023_abnormal_wound_healing0.83459993
97MP0002933_joint_inflammation0.82786593
98MP0000343_altered_response_to0.81832734
99MP0009053_abnormal_anal_canal0.81220402
100MP0001672_abnormal_embryogenesis/_devel0.80198314
101MP0005380_embryogenesis_phenotype0.80198314
102MP0005501_abnormal_skin_physiology0.80135549
103MP0001348_abnormal_lacrimal_gland0.76145445
104MP0003123_paternal_imprinting0.75786353
105MP0005390_skeleton_phenotype0.75732107
106MP0003984_embryonic_growth_retardation0.75416908
107MP0005310_abnormal_salivary_gland0.75054477
108MP0005381_digestive/alimentary_phenotyp0.74920059
109MP0002088_abnormal_embryonic_growth/wei0.74107272
110MP0003448_altered_tumor_morphology0.74090535
111MP0002085_abnormal_embryonic_tissue0.74049666
112MP0002086_abnormal_extraembryonic_tissu0.73979066
113MP0002138_abnormal_hepatobiliary_system0.73665676
114MP0003172_abnormal_lysosome_physiology0.72417855
115MP0001727_abnormal_embryo_implantation0.71025528
116MP0004197_abnormal_fetal_growth/weight/0.68967917
117MP0001216_abnormal_epidermal_layer0.67979667
118MP0004264_abnormal_extraembryonic_tissu0.66730880
119MP0001293_anophthalmia0.66090439
120MP0009764_decreased_sensitivity_to0.64125281
121MP0002084_abnormal_developmental_patter0.63903424
122MP0002089_abnormal_postnatal_growth/wei0.63177018
123MP0009931_abnormal_skin_appearance0.62823709
124MP0010030_abnormal_orbit_morphology0.60474726
125MP0003300_gastrointestinal_ulcer0.58761928
126MP0008469_abnormal_protein_level0.58086981
127MP0000358_abnormal_cell_content/0.57942621
128MP0000372_irregular_coat_pigmentation0.56844732
129MP0001533_abnormal_skeleton_physiology0.55396954
130MP0003566_abnormal_cell_adhesion0.54961027
131MP0003303_peritoneal_inflammation0.54656002
132MP0001663_abnormal_digestive_system0.54444679
133MP0002277_abnormal_respiratory_mucosa0.54376888

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.77774385
2Abnormal number of erythroid precursors (HP:0012131)7.01908743
3Reticulocytopenia (HP:0001896)6.93104436
4Macrocytic anemia (HP:0001972)4.98606013
5Pallor (HP:0000980)4.81764485
6Thrombocytosis (HP:0001894)4.21575933
7IgM deficiency (HP:0002850)3.55742475
8Aplastic anemia (HP:0001915)3.48949423
9Colon cancer (HP:0003003)3.25420122
10Gastrointestinal stroma tumor (HP:0100723)3.10051004
11Elevated erythrocyte sedimentation rate (HP:0003565)3.09847247
12Abnormality of macrophages (HP:0004311)3.05275852
13Chronic otitis media (HP:0000389)3.02064911
14Mediastinal lymphadenopathy (HP:0100721)2.98571668
15Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97496346
1611 pairs of ribs (HP:0000878)2.96734217
17Increased IgE level (HP:0003212)2.88246529
18Colitis (HP:0002583)2.80012013
19Recurrent bronchitis (HP:0002837)2.74257651
20Hypertensive crisis (HP:0100735)2.61353164
21Petechiae (HP:0000967)2.58570009
22Hyperacusis (HP:0010780)2.54036940
23Oral leukoplakia (HP:0002745)2.51350113
24Multiple enchondromatosis (HP:0005701)2.48360239
25Panhypogammaglobulinemia (HP:0003139)2.47247837
26Recurrent viral infections (HP:0004429)2.45608895
27Absent thumb (HP:0009777)2.45563659
28Progressive muscle weakness (HP:0003323)2.44130087
29Abnormality of T cells (HP:0002843)2.41744589
30Deep palmar crease (HP:0006191)2.41320468
31Polygenic inheritance (HP:0010982)2.39350662
32Selective tooth agenesis (HP:0001592)2.35694279
33Abnormality of T cell physiology (HP:0011840)2.33930804
34Birth length less than 3rd percentile (HP:0003561)2.31585496
35Lymphoma (HP:0002665)2.30867399
36Trismus (HP:0000211)2.30659642
37Abnormality of reticulocytes (HP:0004312)2.28886078
38Thoracic kyphosis (HP:0002942)2.25459461
39Cellulitis (HP:0100658)2.23937901
40Asplenia (HP:0001746)2.23681876
41Achilles tendon contracture (HP:0001771)2.23075589
42T lymphocytopenia (HP:0005403)2.23031475
43Myositis (HP:0100614)2.22614905
44Recurrent abscess formation (HP:0002722)2.22046996
45Poikiloderma (HP:0001029)2.21622908
46Myelodysplasia (HP:0002863)2.20014603
47Increased cerebral lipofuscin (HP:0011813)2.19540361
48Emphysema (HP:0002097)2.17323203
49B lymphocytopenia (HP:0010976)2.16112195
50Abnormality of B cell number (HP:0010975)2.16112195
51Agammaglobulinemia (HP:0004432)2.15966750
52Depressed nasal ridge (HP:0000457)2.15721734
53Recurrent skin infections (HP:0001581)2.15668862
54Urticaria (HP:0001025)2.15071181
55Abnormality of T cell number (HP:0011839)2.13711904
56Segmental peripheral demyelination/remyelination (HP:0003481)2.13493447
57Basal cell carcinoma (HP:0002671)2.12733729
58Ragged-red muscle fibers (HP:0003200)2.12374608
59Vertebral compression fractures (HP:0002953)2.10421663
60IgG deficiency (HP:0004315)2.09725655
61Abnormality of the thoracic spine (HP:0100711)2.09160316
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.08413054
63Microretrognathia (HP:0000308)2.07632328
64Long palpebral fissure (HP:0000637)2.07631325
65Stenosis of the external auditory canal (HP:0000402)2.05675758
66Vasculitis (HP:0002633)2.05597986
67Chronic mucocutaneous candidiasis (HP:0002728)2.04901526
68Recurrent cutaneous fungal infections (HP:0011370)2.04901526
69Lymphopenia (HP:0001888)2.03530035
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.02739964
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.01248681
72Recurrent fungal infections (HP:0002841)2.01242146
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.00842974
74Rough bone trabeculation (HP:0100670)2.00809179
75Pustule (HP:0200039)2.00202702
76Broad distal phalanx of finger (HP:0009836)1.99422843
77Increased IgM level (HP:0003496)1.98222927
78Meningitis (HP:0001287)1.96390711
79Abnormal hemoglobin (HP:0011902)1.95537840
80Recurrent gram-negative bacterial infections (HP:0005420)1.94194765
81Partial duplication of thumb phalanx (HP:0009944)1.94087182
82Carpal bone hypoplasia (HP:0001498)1.93870598
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93845386
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93845386
85Amaurosis fugax (HP:0100576)1.93652067
86Exertional dyspnea (HP:0002875)1.93087240
87Migraine (HP:0002076)1.93044663
88Glossoptosis (HP:0000162)1.92740779
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.92047198
90Granulocytopenia (HP:0001913)1.90233680
91Prolonged bleeding time (HP:0003010)1.87021631
92Congenital, generalized hypertrichosis (HP:0004540)1.86902758
93Encephalitis (HP:0002383)1.84988682
94Gastrointestinal inflammation (HP:0004386)1.84877893
95Recurrent bacterial skin infections (HP:0005406)1.84614983
96Thick lower lip vermilion (HP:0000179)1.84179985
97Increased serum ferritin (HP:0003281)1.83716948
98Abnormal number of incisors (HP:0011064)1.83343260
99Abnormality of the Achilles tendon (HP:0005109)1.83175199
100Seborrheic dermatitis (HP:0001051)1.81634012
101Microvesicular hepatic steatosis (HP:0001414)1.81515012
102Increased muscle lipid content (HP:0009058)1.81439593
103Breast hypoplasia (HP:0003187)1.79974622
104Nasal polyposis (HP:0100582)1.79870334
105Pancytopenia (HP:0001876)1.78599578
106Premature graying of hair (HP:0002216)1.78493000
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78245021
108Severe combined immunodeficiency (HP:0004430)1.77608165
109Patellar aplasia (HP:0006443)1.76967905
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76807354
111Cellular immunodeficiency (HP:0005374)1.76469560
112Cleft eyelid (HP:0000625)1.76332457
113Viral hepatitis (HP:0006562)1.76203292
114Combined immunodeficiency (HP:0005387)1.76109632
115Type I transferrin isoform profile (HP:0003642)1.75970551
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.75614099
117Hypergammaglobulinemia (HP:0010702)1.75555651
118Progressive external ophthalmoplegia (HP:0000590)1.75532681
119Hypoplasia of the radius (HP:0002984)1.75345049
120Neoplasm of the pancreas (HP:0002894)1.75204251
121Thin bony cortex (HP:0002753)1.74893407
122Verrucae (HP:0200043)1.74743064
123Papilloma (HP:0012740)1.74743064
124Partial duplication of the phalanx of hand (HP:0009999)1.74478558
125Gingivitis (HP:0000230)1.74460944
126Inflammation of the large intestine (HP:0002037)1.74016589
127Degeneration of anterior horn cells (HP:0002398)1.73683615
128Abnormality of the anterior horn cell (HP:0006802)1.73683615
129Triphalangeal thumb (HP:0001199)1.71941488
130Increased hepatocellular lipid droplets (HP:0006565)1.71528523
131Muscle fiber atrophy (HP:0100295)1.71504224
132Disproportionate tall stature (HP:0001519)1.71114127
133Spinal cord lesions (HP:0100561)1.70987578
134Syringomyelia (HP:0003396)1.70987578
135Abnormality of liposaccharide metabolism (HP:0010968)1.70842474
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.70842474
137Abnormality of glycolipid metabolism (HP:0010969)1.70842474
138Agnosia (HP:0010524)1.70568356
139Restrictive lung disease (HP:0002091)1.70516049
140Increased intramyocellular lipid droplets (HP:0012240)1.69819664
141Abnormality of the nasal mucosa (HP:0000433)1.69743199
142Orchitis (HP:0100796)1.68539630
143Bone marrow hypocellularity (HP:0005528)1.68387344
144Aplasia/Hypoplasia of the patella (HP:0006498)1.68287430
145Gastrointestinal infarctions (HP:0005244)1.68132068
146Acute lymphatic leukemia (HP:0006721)1.67642015
147Obstructive lung disease (HP:0006536)1.67434481
148Chronic obstructive pulmonary disease (HP:0006510)1.67434481
149Eczematoid dermatitis (HP:0000976)1.66284522
150Eosinophilia (HP:0001880)1.66189890
151Missing ribs (HP:0000921)1.65850141
152Recurrent lower respiratory tract infections (HP:0002783)1.65534230
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.64867938
154Skin ulcer (HP:0200042)1.64646222
155Abnormality of the preputium (HP:0100587)1.64642277
156Respiratory difficulties (HP:0002880)1.63846698
157Purpura (HP:0000979)1.62649766
158IgA deficiency (HP:0002720)1.61754677
159Squamous cell carcinoma (HP:0002860)1.61615233
160Hyperparathyroidism (HP:0000843)1.58987150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.34694407
2SMG13.87295619
3MAP4K13.25481690
4PRPF4B3.20378097
5EEF2K3.19536060
6BUB12.96330041
7WEE12.72825609
8RPS6KB22.43580318
9LRRK22.23087890
10TGFBR12.21234968
11VRK21.99797605
12PIM21.98493204
13STK161.97880083
14PASK1.88077024
15CDC71.82306718
16ICK1.75009687
17RIPK41.74387269
18ARAF1.73928197
19BTK1.69667166
20MAP3K101.68532765
21FLT31.67419307
22DYRK31.65995376
23VRK11.64270469
24MST41.61941290
25SIK11.61699711
26MAP3K131.60320221
27TESK21.59974424
28SRPK11.56623894
29EIF2AK11.56551183
30KIT1.55894341
31RPS6KA41.55510693
32NEK21.55392673
33STK101.53136255
34BLK1.49141200
35ZAP701.46816847
36TEC1.41587274
37TSSK61.39559625
38TAOK21.38791319
39TLK11.35560794
40MAP2K31.34025619
41ACVR1B1.31997023
42PKN21.30742821
43MKNK11.27433786
44BRAF1.25425614
45CSF1R1.24091696
46EIF2AK31.23400414
47CDK121.21046621
48PIM11.20554824
49TYK21.18737440
50MAP3K141.18600914
51KDR1.18361462
52CLK11.17401051
53JAK31.15518737
54CDK71.14983443
55MAPKAPK31.14557056
56GRK61.13230308
57AURKB1.13032568
58BRSK21.11105028
59TXK1.10630059
60IKBKB1.05733176
61FGFR41.05484366
62PAK41.04613339
63ILK1.03489413
64MAP3K81.01592357
65CSK0.99548746
66ATR0.98073014
67IRAK40.97050176
68TBK10.96715103
69SYK0.95693001
70CDK40.94935610
71STK40.93830635
72PTK60.87734749
73NLK0.86917124
74IRAK20.83286211
75DAPK30.82289949
76FES0.79754514
77ITK0.79422161
78PLK10.79291974
79MAP3K10.79261983
80LCK0.78753956
81RIPK10.76925225
82IKBKE0.75080555
83CDK190.74490466
84LYN0.71672049
85SCYL20.71280407
86RPS6KA50.70969168
87PDPK10.69843865
88HIPK20.69218427
89MAP3K110.65269281
90CDC42BPA0.64379488
91TYRO30.63037971
92TTK0.62488765
93CSNK2A20.61247862
94MARK20.60740701
95RPS6KA20.59635235
96TAOK10.59526751
97MAP2K20.59172705
98TAF10.58728591
99MAP3K30.57523781
100CDK80.56876405
101MAPK110.56617800
102MTOR0.55733081
103ABL20.54786559
104PLK40.53636787
105PRKD20.53300023
106AURKA0.52039567
107CHEK10.51613816
108MOS0.51399329
109PAK10.51212692
110CSNK2A10.50969033
111TESK10.50713531
112DYRK1B0.49949715
113KSR20.49762173
114EPHB20.49291863
115RPS6KA10.48926085
116TGFBR20.48447353
117RPS6KA60.47575406
118HCK0.47080379
119NME10.46343992
120TTN0.46198255
121MAPKAPK20.45674630
122TRIB30.44884190
123CDK60.43013092
124CHUK0.42257626
125RPS6KL10.41876531
126RPS6KC10.41876531
127PAK20.41069925
128MARK30.41044271
129SIK20.40993750
130MKNK20.40963783
131CDK90.40460604
132MATK0.40348265
133PDK10.39423727
134CAMKK10.38519996
135PRKD30.38443433
136CHEK20.38061162
137MAPKAPK50.37691680
138BMX0.37601083
139EPHA20.34970575
140IRAK30.33871943
141ERN10.33399390
142BRSK10.32968910
143CDK20.31629730
144MAP2K60.30691976
145TRPM70.30515216

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.47128473
2DNA replication_Homo sapiens_hsa030303.97282442
3Mismatch repair_Homo sapiens_hsa034303.27433845
4Proteasome_Homo sapiens_hsa030503.06248913
5Spliceosome_Homo sapiens_hsa030402.92769876
6RNA polymerase_Homo sapiens_hsa030202.82965968
7Base excision repair_Homo sapiens_hsa034102.51148184
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32276241
9Homologous recombination_Homo sapiens_hsa034402.30717762
10Nucleotide excision repair_Homo sapiens_hsa034202.27803846
11Pyrimidine metabolism_Homo sapiens_hsa002402.12997772
12RNA transport_Homo sapiens_hsa030132.05840790
13Primary immunodeficiency_Homo sapiens_hsa053402.02656680
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77610424
15Non-homologous end-joining_Homo sapiens_hsa034501.73609224
16Cell cycle_Homo sapiens_hsa041101.65348744
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53439822
18One carbon pool by folate_Homo sapiens_hsa006701.52655455
19RNA degradation_Homo sapiens_hsa030181.42026755
20Protein export_Homo sapiens_hsa030601.41181642
21Antigen processing and presentation_Homo sapiens_hsa046121.38472637
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38366408
23Fanconi anemia pathway_Homo sapiens_hsa034601.35401235
24Bladder cancer_Homo sapiens_hsa052191.34915110
25p53 signaling pathway_Homo sapiens_hsa041151.29108398
26Epstein-Barr virus infection_Homo sapiens_hsa051691.20587183
27Herpes simplex infection_Homo sapiens_hsa051681.20356832
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19790740
29Basal transcription factors_Homo sapiens_hsa030221.18980690
30Hematopoietic cell lineage_Homo sapiens_hsa046401.14054146
31Type I diabetes mellitus_Homo sapiens_hsa049401.12376191
32Non-small cell lung cancer_Homo sapiens_hsa052231.11607584
33VEGF signaling pathway_Homo sapiens_hsa043701.11221760
34Staphylococcus aureus infection_Homo sapiens_hsa051501.10133339
35Parkinsons disease_Homo sapiens_hsa050121.09779479
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.07940312
37Measles_Homo sapiens_hsa051621.06440689
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.04631467
39Pancreatic cancer_Homo sapiens_hsa052121.03707977
40Systemic lupus erythematosus_Homo sapiens_hsa053221.00773464
41mRNA surveillance pathway_Homo sapiens_hsa030150.98998167
42Galactose metabolism_Homo sapiens_hsa000520.98414042
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96543337
44Purine metabolism_Homo sapiens_hsa002300.96260353
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93873460
46Leishmaniasis_Homo sapiens_hsa051400.93809909
47Oxidative phosphorylation_Homo sapiens_hsa001900.90770773
48Legionellosis_Homo sapiens_hsa051340.90697828
49B cell receptor signaling pathway_Homo sapiens_hsa046620.87862173
50Viral carcinogenesis_Homo sapiens_hsa052030.86741099
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.85085071
52Fructose and mannose metabolism_Homo sapiens_hsa000510.84863824
53Huntingtons disease_Homo sapiens_hsa050160.84350256
54Sulfur relay system_Homo sapiens_hsa041220.83772847
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81115638
56Allograft rejection_Homo sapiens_hsa053300.79382736
57Pentose phosphate pathway_Homo sapiens_hsa000300.78049255
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76673450
59HTLV-I infection_Homo sapiens_hsa051660.76317307
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75874861
61Shigellosis_Homo sapiens_hsa051310.75850549
62Apoptosis_Homo sapiens_hsa042100.75512282
63Biosynthesis of amino acids_Homo sapiens_hsa012300.74752433
64Prion diseases_Homo sapiens_hsa050200.74289247
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71623530
66Chemokine signaling pathway_Homo sapiens_hsa040620.71006833
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.70105036
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.67335128
69Endometrial cancer_Homo sapiens_hsa052130.66903290
70Small cell lung cancer_Homo sapiens_hsa052220.66726899
71T cell receptor signaling pathway_Homo sapiens_hsa046600.65483875
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.65090092
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63904118
74Rheumatoid arthritis_Homo sapiens_hsa053230.63664570
75Asthma_Homo sapiens_hsa053100.63599630
76Acute myeloid leukemia_Homo sapiens_hsa052210.63440966
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59813040
78Hepatitis B_Homo sapiens_hsa051610.59440830
79Lysosome_Homo sapiens_hsa041420.59253743
80Thyroid cancer_Homo sapiens_hsa052160.57032369
81Chronic myeloid leukemia_Homo sapiens_hsa052200.55542944
82Influenza A_Homo sapiens_hsa051640.54987186
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.54810776
84Notch signaling pathway_Homo sapiens_hsa043300.54343445
85Folate biosynthesis_Homo sapiens_hsa007900.52552136
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52543736
87Toxoplasmosis_Homo sapiens_hsa051450.52514049
88Viral myocarditis_Homo sapiens_hsa054160.52473176
89Renal cell carcinoma_Homo sapiens_hsa052110.51653354
90Alzheimers disease_Homo sapiens_hsa050100.51380422
91Osteoclast differentiation_Homo sapiens_hsa043800.50957532
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50333069
93Graft-versus-host disease_Homo sapiens_hsa053320.50122230
94Glutathione metabolism_Homo sapiens_hsa004800.49889936
95N-Glycan biosynthesis_Homo sapiens_hsa005100.49790509
96Phagosome_Homo sapiens_hsa041450.49296938
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48638059
98Pertussis_Homo sapiens_hsa051330.45220178
99mTOR signaling pathway_Homo sapiens_hsa041500.44988052
100Other glycan degradation_Homo sapiens_hsa005110.44826302
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.43789776
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43539992
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42666502
104Prolactin signaling pathway_Homo sapiens_hsa049170.42341787
105Prostate cancer_Homo sapiens_hsa052150.41893232
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41826605
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.40245690
108Malaria_Homo sapiens_hsa051440.39111487
109Autoimmune thyroid disease_Homo sapiens_hsa053200.38109897
110MicroRNAs in cancer_Homo sapiens_hsa052060.37979366
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36866887
112Insulin signaling pathway_Homo sapiens_hsa049100.36499302
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.36021515
114Colorectal cancer_Homo sapiens_hsa052100.34588362
115Platelet activation_Homo sapiens_hsa046110.34429870
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31958258
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31468133
118Pathways in cancer_Homo sapiens_hsa052000.31357000
119HIF-1 signaling pathway_Homo sapiens_hsa040660.28628857
120Arachidonic acid metabolism_Homo sapiens_hsa005900.28401620
121Salmonella infection_Homo sapiens_hsa051320.26995793
122TNF signaling pathway_Homo sapiens_hsa046680.25987402
123Hepatitis C_Homo sapiens_hsa051600.25499166
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24962340
125Alcoholism_Homo sapiens_hsa050340.24954463
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24550776
127Tuberculosis_Homo sapiens_hsa051520.22339207

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