RPS9P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.27033324
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.03682567
3cytidine catabolic process (GO:0006216)6.55689049
4cytidine deamination (GO:0009972)6.55689049
5cytidine metabolic process (GO:0046087)6.55689049
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.87578079
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.22436863
8actin nucleation (GO:0045010)4.64014059
9cellular response to interleukin-15 (GO:0071350)4.33208269
10negative regulation of T cell apoptotic process (GO:0070233)4.22482687
11negative T cell selection (GO:0043383)4.05902467
12T cell migration (GO:0072678)3.98409326
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91032246
14positive thymic T cell selection (GO:0045059)3.79932118
15sequestering of actin monomers (GO:0042989)3.75783629
16platelet dense granule organization (GO:0060155)3.75778322
17adenosine metabolic process (GO:0046085)3.71662564
18regulation of B cell receptor signaling pathway (GO:0050855)3.60935753
19negative regulation of stress fiber assembly (GO:0051497)3.57490488
20negative thymic T cell selection (GO:0045060)3.52458460
21regulation of T cell receptor signaling pathway (GO:0050856)3.51848345
22purine deoxyribonucleotide catabolic process (GO:0009155)3.45011167
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43502943
24positive T cell selection (GO:0043368)3.40986166
25sleep (GO:0030431)3.39971999
26positive regulation of uterine smooth muscle contraction (GO:0070474)3.39825067
27positive regulation of calcium-mediated signaling (GO:0050850)3.35870702
28mannosylation (GO:0097502)3.32781080
29positive regulation of T cell mediated cytotoxicity (GO:0001916)3.28630436
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.28543867
31negative regulation of lymphocyte apoptotic process (GO:0070229)3.21270680
32xenobiotic catabolic process (GO:0042178)3.20971981
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16993140
34positive regulation of natural killer cell mediated immunity (GO:0002717)3.10112515
35T cell receptor signaling pathway (GO:0050852)3.09570407
36regulation of T cell mediated cytotoxicity (GO:0001914)3.08833722
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08776823
38regulation of gamma-delta T cell differentiation (GO:0045586)3.08600439
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08526721
40negative regulation of cell killing (GO:0031342)3.08526721
41thymic T cell selection (GO:0045061)3.08056340
42regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07478689
43proteasome assembly (GO:0043248)3.06729322
44cytolysis (GO:0019835)3.06622103
45iron-sulfur cluster assembly (GO:0016226)3.05950603
46metallo-sulfur cluster assembly (GO:0031163)3.05950603
47positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.04172252
48response to interleukin-15 (GO:0070672)3.03596593
49negative regulation of viral genome replication (GO:0045071)2.98370783
50pyrimidine nucleoside catabolic process (GO:0046135)2.97918357
51positive regulation of interleukin-4 production (GO:0032753)2.95107895
52ribosomal small subunit assembly (GO:0000028)2.93684247
53response to interferon-beta (GO:0035456)2.93417100
54negative regulation by host of viral transcription (GO:0043922)2.92890836
55lymphocyte chemotaxis (GO:0048247)2.91064221
56regulation of cellular amino acid metabolic process (GO:0006521)2.90768173
57regulation of activation of Janus kinase activity (GO:0010533)2.90740711
58positive regulation of cell killing (GO:0031343)2.88149821
59positive regulation of prostaglandin secretion (GO:0032308)2.85199318
60protein deneddylation (GO:0000338)2.85097529
61positive regulation of lamellipodium assembly (GO:0010592)2.85039430
62negative regulation of actin filament bundle assembly (GO:0032232)2.84836899
63negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.84412818
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84212280
65ATP synthesis coupled proton transport (GO:0015986)2.84212280
66chaperone mediated protein folding requiring cofactor (GO:0051085)2.83887357
67mast cell activation (GO:0045576)2.83873940
68immunoglobulin mediated immune response (GO:0016064)2.82813310
69rRNA modification (GO:0000154)2.80891918
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78589442
71regulation of T cell apoptotic process (GO:0070232)2.78254155
72natural killer cell activation (GO:0030101)2.77558779
73positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77467493
74positive regulation of interleukin-8 secretion (GO:2000484)2.77351787
75regulation of chronic inflammatory response (GO:0002676)2.77116178
76positive regulation of tolerance induction (GO:0002645)2.75300052
77lymphocyte migration (GO:0072676)2.75189039
78regulation of cell killing (GO:0031341)2.74855134
79base-excision repair, AP site formation (GO:0006285)2.73050223
80regulation of natural killer cell mediated immunity (GO:0002715)2.72032609
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72032609
82protein complex biogenesis (GO:0070271)2.71477816
83positive regulation of gamma-delta T cell activation (GO:0046645)2.70358941
84regulation of regulatory T cell differentiation (GO:0045589)2.69802687
85GDP-mannose metabolic process (GO:0019673)2.69610290
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68751268
87piRNA metabolic process (GO:0034587)2.66677593
88electron transport chain (GO:0022900)2.64846522
89positive regulation of defense response to virus by host (GO:0002230)2.64488123
90purine deoxyribonucleotide metabolic process (GO:0009151)2.64254042
91mast cell activation involved in immune response (GO:0002279)2.64051934
92mast cell degranulation (GO:0043303)2.64051934
93positive regulation of granulocyte differentiation (GO:0030854)2.63974312
94respiratory electron transport chain (GO:0022904)2.61884580
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61344500
96T cell costimulation (GO:0031295)2.61234640
97positive regulation of T cell cytokine production (GO:0002726)2.58534307
98lymphocyte costimulation (GO:0031294)2.58446014
99antigen receptor-mediated signaling pathway (GO:0050851)2.57729151
100positive regulation of T cell mediated immunity (GO:0002711)2.57357452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.06694497
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.82784338
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.00074458
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.94654198
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70543255
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12093962
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05607780
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.63504080
9MYB_26560356_Chip-Seq_TH2_Human2.59651403
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47345120
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42666633
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.35643291
13RUNX_20019798_ChIP-Seq_JUKART_Human2.34375955
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.33678274
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28505206
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23643182
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10343093
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09416284
19VDR_23849224_ChIP-Seq_CD4+_Human2.07703127
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.07127519
21GATA3_26560356_Chip-Seq_TH2_Human2.00101395
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94638808
23GATA3_27048872_Chip-Seq_THYMUS_Human1.93650343
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93021944
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89802136
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86835373
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73743701
28FOXP3_21729870_ChIP-Seq_TREG_Human1.70846168
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70245797
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.65819779
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64073225
32UTX_26944678_Chip-Seq_JUKART_Human1.57543373
33VDR_22108803_ChIP-Seq_LS180_Human1.55817075
34BCL6_27268052_Chip-Seq_Bcells_Human1.54203012
35ERG_20517297_ChIP-Seq_VCAP_Human1.52641767
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49609038
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.45541380
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42471113
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41890622
40MYB_26560356_Chip-Seq_TH1_Human1.41343119
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.40147971
42SPI1_23547873_ChIP-Seq_NB4_Human1.37254330
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.36192856
44AR_20517297_ChIP-Seq_VCAP_Human1.36181016
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35108060
46ZNF274_21170338_ChIP-Seq_K562_Hela1.33501031
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31398255
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29609920
49SCL_19346495_ChIP-Seq_HPC-7_Human1.29071111
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28375848
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27644726
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27410896
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26724180
54NANOG_20526341_ChIP-Seq_ESCs_Human1.26084372
55MAF_26560356_Chip-Seq_TH2_Human1.25217881
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24031741
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23042833
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.23042833
59IGF1R_20145208_ChIP-Seq_DFB_Human1.21850027
60FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21107477
61TP53_22573176_ChIP-Seq_HFKS_Human1.20169630
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19334156
63ERA_21632823_ChIP-Seq_H3396_Human1.19029067
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18771387
65CIITA_25753668_ChIP-Seq_RAJI_Human1.15278962
66MYC_19829295_ChIP-Seq_ESCs_Human1.14429751
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14061764
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.12776881
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09666108
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09383368
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.07843957
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07370754
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07249565
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05529698
75ELK1_19687146_ChIP-ChIP_HELA_Human1.05275034
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.03784649
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03659927
78P300_27268052_Chip-Seq_Bcells_Human1.03598784
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03539778
80CTCF_20526341_ChIP-Seq_ESCs_Human1.03510477
81ER_23166858_ChIP-Seq_MCF-7_Human1.02279010
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01643785
83TAF2_19829295_ChIP-Seq_ESCs_Human1.01083218
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00807801
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.99976764
86MYC_18940864_ChIP-ChIP_HL60_Human0.98559238
87NCOR_22424771_ChIP-Seq_293T_Human0.97548002
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97148043
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95274792
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95266953
91MAF_26560356_Chip-Seq_TH1_Human0.94639482
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94151569
93GATA3_26560356_Chip-Seq_TH1_Human0.93852996
94RAC3_21632823_ChIP-Seq_H3396_Human0.92796157
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91568455
96HOXB7_26014856_ChIP-Seq_BT474_Human0.91246126
97BCOR_27268052_Chip-Seq_Bcells_Human0.89757654
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88734147
99SA1_27219007_Chip-Seq_Bcells_Human0.88273107
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.87903172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.18390620
2MP0001835_abnormal_antigen_presentation3.09716736
3MP0005075_abnormal_melanosome_morpholog3.05825687
4MP0003763_abnormal_thymus_physiology3.01742992
5MP0009785_altered_susceptibility_to2.88427014
6MP0003195_calcinosis2.73206363
7MP0002166_altered_tumor_susceptibility2.70454617
8MP0005000_abnormal_immune_tolerance2.55524282
9MP0002138_abnormal_hepatobiliary_system2.43347354
10MP0006072_abnormal_retinal_apoptosis2.41620859
11MP0005377_hearing/vestibular/ear_phenot2.31418009
12MP0003878_abnormal_ear_physiology2.31418009
13MP0002148_abnormal_hypersensitivity_rea2.20931117
14MP0003724_increased_susceptibility_to2.10888875
15MP0002006_tumorigenesis2.04760841
16MP0002420_abnormal_adaptive_immunity2.01033039
17MP0001819_abnormal_immune_cell1.99967727
18MP0002876_abnormal_thyroid_physiology1.99222804
19MP0002723_abnormal_immune_serum1.98643022
20MP0009333_abnormal_splenocyte_physiolog1.92804207
21MP0001800_abnormal_humoral_immune1.90018805
22MP0005646_abnormal_pituitary_gland1.89362753
23MP0001905_abnormal_dopamine_level1.88961061
24MP0005025_abnormal_response_to1.85585347
25MP0003806_abnormal_nucleotide_metabolis1.84908820
26MP0003866_abnormal_defecation1.67004485
27MP0002102_abnormal_ear_morphology1.66854632
28MP0002452_abnormal_antigen_presenting1.66834907
29MP0002405_respiratory_system_inflammati1.64789238
30MP0006082_CNS_inflammation1.62893256
31MP0000685_abnormal_immune_system1.60409186
32MP0008877_abnormal_DNA_methylation1.53825507
33MP0005464_abnormal_platelet_physiology1.51282623
34MP0000716_abnormal_immune_system1.48745243
35MP0002933_joint_inflammation1.46742619
36MP0002837_dystrophic_cardiac_calcinosis1.45443747
37MP0002398_abnormal_bone_marrow1.44560846
38MP0005387_immune_system_phenotype1.40891308
39MP0001790_abnormal_immune_system1.40891308
40MP0003436_decreased_susceptibility_to1.37620797
41MP0000703_abnormal_thymus_morphology1.34855691
42MP0005174_abnormal_tail_pigmentation1.34402922
43MP0005645_abnormal_hypothalamus_physiol1.30571337
44MP0001919_abnormal_reproductive_system1.30475929
45MP0002722_abnormal_immune_system1.30158755
46MP0001845_abnormal_inflammatory_respons1.28102996
47MP0008872_abnormal_physiological_respon1.26284978
48MP0003011_delayed_dark_adaptation1.25470922
49MP0004145_abnormal_muscle_electrophysio1.25054390
50MP0005389_reproductive_system_phenotype1.23552046
51MP0010155_abnormal_intestine_physiology1.22444452
52MP0004381_abnormal_hair_follicle1.19827240
53MP0002419_abnormal_innate_immunity1.17549304
54MP0000689_abnormal_spleen_morphology1.17438828
55MP0001501_abnormal_sleep_pattern1.16866556
56MP0006036_abnormal_mitochondrial_physio1.16691957
57MP0003879_abnormal_hair_cell1.16077532
58MP0002139_abnormal_hepatobiliary_system1.15673291
59MP0005410_abnormal_fertilization1.12057973
60MP0002909_abnormal_adrenal_gland1.12050797
61MP0001873_stomach_inflammation1.11024918
62MP0008875_abnormal_xenobiotic_pharmacok1.10884400
63MP0002429_abnormal_blood_cell1.10730774
64MP0005551_abnormal_eye_electrophysiolog1.09812408
65MP0000372_irregular_coat_pigmentation1.08245740
66MP0005253_abnormal_eye_physiology1.05971980
67MP0005379_endocrine/exocrine_gland_phen1.05643821
68MP0010386_abnormal_urinary_bladder1.04838662
69MP0009384_cardiac_valve_regurgitation1.03035984
70MP0002160_abnormal_reproductive_system1.02725246
71MP0003786_premature_aging1.00823235
72MP0009379_abnormal_foot_pigmentation1.00110191
73MP0009697_abnormal_copulation0.98789990
74MP0000613_abnormal_salivary_gland0.96442052
75MP0002877_abnormal_melanocyte_morpholog0.95666983
76MP0001968_abnormal_touch/_nociception0.95291722
77MP0009643_abnormal_urine_homeostasis0.94671732
78MP0004043_abnormal_pH_regulation0.90596445
79MP0002693_abnormal_pancreas_physiology0.89440540
80MP0001533_abnormal_skeleton_physiology0.88313937
81MP0002736_abnormal_nociception_after0.86902934
82MP0003172_abnormal_lysosome_physiology0.85460809
83MP0005084_abnormal_gallbladder_morpholo0.85386298
84MP0001529_abnormal_vocalization0.83778306
85MP0008469_abnormal_protein_level0.81620934
86MP0003183_abnormal_peptide_metabolism0.80731180
87MP0003646_muscle_fatigue0.79577656
88MP0006276_abnormal_autonomic_nervous0.78702852
89MP0005166_decreased_susceptibility_to0.78549598
90MP0001765_abnormal_ion_homeostasis0.77664543
91MP0005360_urolithiasis0.77359980
92MP0003638_abnormal_response/metabolism_0.77248096
93MP0003045_fibrosis0.76757649
94MP0001764_abnormal_homeostasis0.76194302
95MP0002163_abnormal_gland_morphology0.75054479
96MP0000465_gastrointestinal_hemorrhage0.73637776
97MP0003448_altered_tumor_morphology0.72298419
98MP0004134_abnormal_chest_morphology0.70811482
99MP0005636_abnormal_mineral_homeostasis0.70775456
100MP0002019_abnormal_tumor_incidence0.70662632

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)4.82735265
2Aplastic anemia (HP:0001915)4.50914531
3Abnormality of T cell number (HP:0011839)4.21373278
4T lymphocytopenia (HP:0005403)4.19194610
5Elevated erythrocyte sedimentation rate (HP:0003565)4.01206346
6Abnormality of the prostate (HP:0008775)3.79795356
7IgG deficiency (HP:0004315)3.71232373
8Prostate neoplasm (HP:0100787)3.70112122
9Combined immunodeficiency (HP:0005387)3.67949215
10Mitochondrial inheritance (HP:0001427)3.51744226
11Abnormality of B cell number (HP:0010975)3.44656032
12Thyroiditis (HP:0100646)3.39414803
13Hepatocellular necrosis (HP:0001404)3.37283064
14Autoimmune hemolytic anemia (HP:0001890)3.31528563
15Abnormality of eosinophils (HP:0001879)3.28684368
16Abnormality of T cells (HP:0002843)3.21295153
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17707017
18Abnormal mitochondria in muscle tissue (HP:0008316)3.10780234
19Pigmentary retinal degeneration (HP:0001146)3.10347730
20Hepatic necrosis (HP:0002605)3.10289760
21Hypoproteinemia (HP:0003075)3.09750440
22Acute necrotizing encephalopathy (HP:0006965)3.07489313
23B lymphocytopenia (HP:0010976)3.06433798
24Abnormal albumin level (HP:0012116)2.97032656
25Hypoalbuminemia (HP:0003073)2.97032656
26Mesangial abnormality (HP:0001966)2.89486231
27Renal cortical cysts (HP:0000803)2.81857387
28Type I transferrin isoform profile (HP:0003642)2.80711710
29Amyotrophic lateral sclerosis (HP:0007354)2.74859468
30Increased IgM level (HP:0003496)2.74688516
31Abnormal rod and cone electroretinograms (HP:0008323)2.72425513
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67730989
33Abnormal protein N-linked glycosylation (HP:0012347)2.67730989
34Abnormal protein glycosylation (HP:0012346)2.67730989
35Abnormal glycosylation (HP:0012345)2.67730989
36Autoimmune thrombocytopenia (HP:0001973)2.61387648
37Eosinophilia (HP:0001880)2.60521766
38Increased intramyocellular lipid droplets (HP:0012240)2.59597027
39Increased CSF lactate (HP:0002490)2.58592963
40Progressive macrocephaly (HP:0004481)2.58399331
41Congenital stationary night blindness (HP:0007642)2.51988013
42Aplasia/hypoplasia of the uterus (HP:0008684)2.50018765
43Petechiae (HP:0000967)2.48124775
44Retinal atrophy (HP:0001105)2.45896918
453-Methylglutaconic aciduria (HP:0003535)2.45233474
46Pustule (HP:0200039)2.43990745
47Pancytopenia (HP:0001876)2.43246290
48Joint swelling (HP:0001386)2.41368512
49Stomatitis (HP:0010280)2.38327399
50Acute encephalopathy (HP:0006846)2.37670705
51Hypoplasia of the uterus (HP:0000013)2.35982120
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34142797
53Dicarboxylic aciduria (HP:0003215)2.31971487
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31971487
55Leukocytosis (HP:0001974)2.31857843
56Abolished electroretinogram (ERG) (HP:0000550)2.31436723
57Ketosis (HP:0001946)2.25231107
58Granulocytopenia (HP:0001913)2.24384058
59Chronic diarrhea (HP:0002028)2.23555021
60Increased muscle lipid content (HP:0009058)2.23085609
61Lactic acidosis (HP:0003128)2.20314605
62Renal Fanconi syndrome (HP:0001994)2.15992286
63Generalized aminoaciduria (HP:0002909)2.13728364
64Cerebral edema (HP:0002181)2.13501190
65Abnormality of T cell physiology (HP:0011840)2.13034395
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13005923
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13005923
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12015841
69Hypophosphatemic rickets (HP:0004912)2.09172877
70Opisthotonus (HP:0002179)2.06109238
71Abnormality of male internal genitalia (HP:0000022)2.05291227
72Attenuation of retinal blood vessels (HP:0007843)2.04377388
73Reduced antithrombin III activity (HP:0001976)2.03721348
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02937857
75Abnormality of the renal cortex (HP:0011035)2.02361422
76Myositis (HP:0100614)2.02261395
77Absent thumb (HP:0009777)1.89293099
78Methylmalonic acidemia (HP:0002912)1.85989199
79Pancreatic cysts (HP:0001737)1.85039847
80Abnormality of midbrain morphology (HP:0002418)1.82889977
81Molar tooth sign on MRI (HP:0002419)1.82889977
82Increased serum lactate (HP:0002151)1.80430361
83Lethargy (HP:0001254)1.79598742
84Hypergammaglobulinemia (HP:0010702)1.78505122
85Failure to thrive in infancy (HP:0001531)1.77740076
86Optic disc pallor (HP:0000543)1.76248540
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.76155391
88Methylmalonic aciduria (HP:0012120)1.76077515
89IgM deficiency (HP:0002850)1.74868605
90Recurrent bronchitis (HP:0002837)1.73825038
91Alveolar cell carcinoma (HP:0006519)1.73048037
92Abnormality of fatty-acid metabolism (HP:0004359)1.71963866
93Glycosuria (HP:0003076)1.69214804
94Abnormality of urine glucose concentration (HP:0011016)1.69214804
95Cerebral palsy (HP:0100021)1.69029913
96Progressive neurologic deterioration (HP:0002344)1.68647232
97Abnormality of liposaccharide metabolism (HP:0010968)1.67891771
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.67891771
99Abnormality of glycolipid metabolism (HP:0010969)1.67891771
100Conical tooth (HP:0000698)1.65525399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.11410551
2TESK24.56549493
3TXK4.23100225
4TAOK33.38757813
5MUSK3.10406999
6BCKDK2.97231151
7GRK62.89777851
8TESK12.69488641
9VRK22.57216478
10SCYL22.28826813
11TLK12.17562848
12MAP4K12.14037507
13LIMK12.07390346
14ITK1.91113769
15ADRBK21.88202760
16TEC1.86327281
17MAPKAPK31.77348118
18TBK11.76943049
19IKBKE1.74149550
20ZAK1.70233378
21PINK11.68280789
22GRK11.63564748
23MST41.45832806
24MYLK1.40425420
25IKBKB1.38918068
26BTK1.38565270
27MAP3K121.34814248
28ZAP701.32335602
29TNK21.30051038
30KIT1.26417696
31PIK3CG1.22141039
32SYK1.14184296
33NUAK11.13521987
34MAP4K21.12390993
35FRK1.10704440
36VRK11.10138001
37FES1.09307852
38PRKCQ1.06929224
39LCK0.99725020
40LYN0.95207088
41MAP3K140.94013664
42CSF1R0.89839099
43MAP2K20.87093719
44FLT30.86890713
45WNK40.85503357
46ERBB30.85030112
47CSK0.84157624
48PRKD30.83789305
49PIK3CA0.81502278
50DAPK10.79309151
51STK390.74172958
52PASK0.62432283
53JAK10.62349894
54BMPR20.59772114
55OBSCN0.58967359
56MAPKAPK50.56958514
57RPS6KA50.56600005
58MARK30.53956668
59CSNK1G30.53699335
60ARAF0.52741212
61MAP2K70.52069389
62CLK10.50888119
63RPS6KA40.48628032
64PHKG10.47737202
65PHKG20.47737202
66CDK30.47007584
67PIM20.46504529
68ABL10.44187717
69TRPM70.42922142
70PRKG20.42268481
71INSRR0.42002354
72MATK0.40124244
73INSR0.39339806
74MAP3K40.38754876
75JAK30.38167512
76ADRBK10.36866343
77IGF1R0.36172491
78MAPK130.35242087
79PRKD20.34002104
80RPS6KB20.33640810
81PRKCA0.32300281
82HCK0.32128720
83ILK0.31386871
84MAP3K110.30609703
85PKN10.29930713
86GRK70.29822053
87EPHA20.29022835
88NEK60.28726388
89EGFR0.28538017
90PIM10.28525630
91AURKA0.28168075
92HIPK20.28128031
93PRKACA0.25988783
94CSNK1G10.25754626
95PRKCE0.25050402
96MAPKAPK20.24853441
97MAP3K50.22783349
98TIE10.22734685
99PRKCH0.22437916
100DAPK30.22370252

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.06268280
2Proteasome_Homo sapiens_hsa030503.87932671
3Graft-versus-host disease_Homo sapiens_hsa053323.20185387
4Oxidative phosphorylation_Homo sapiens_hsa001903.06865213
5Antigen processing and presentation_Homo sapiens_hsa046122.70741636
6Autoimmune thyroid disease_Homo sapiens_hsa053202.66037055
7Allograft rejection_Homo sapiens_hsa053302.64722849
8Protein export_Homo sapiens_hsa030602.58123523
9Parkinsons disease_Homo sapiens_hsa050122.41994199
10Type I diabetes mellitus_Homo sapiens_hsa049402.40527280
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08476344
12Hematopoietic cell lineage_Homo sapiens_hsa046402.02003321
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.85059032
14T cell receptor signaling pathway_Homo sapiens_hsa046601.82705913
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82632921
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78845828
17Asthma_Homo sapiens_hsa053101.71864697
18RNA polymerase_Homo sapiens_hsa030201.70300874
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68981927
20Phototransduction_Homo sapiens_hsa047441.63595325
21Rheumatoid arthritis_Homo sapiens_hsa053231.63209899
22Ribosome_Homo sapiens_hsa030101.56713234
23Alzheimers disease_Homo sapiens_hsa050101.53747393
24Sulfur metabolism_Homo sapiens_hsa009201.49411680
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46069473
26Huntingtons disease_Homo sapiens_hsa050161.28807160
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.25670053
28Caffeine metabolism_Homo sapiens_hsa002321.22371733
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22354701
30Peroxisome_Homo sapiens_hsa041461.10965202
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09469531
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09405494
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08163397
34Fatty acid elongation_Homo sapiens_hsa000621.07968358
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05799718
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01179733
37Cardiac muscle contraction_Homo sapiens_hsa042600.99856460
38Chemical carcinogenesis_Homo sapiens_hsa052040.99258312
39Propanoate metabolism_Homo sapiens_hsa006400.97156510
40Measles_Homo sapiens_hsa051620.95153637
41Butanoate metabolism_Homo sapiens_hsa006500.91981580
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90598958
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90381713
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90375103
45Collecting duct acid secretion_Homo sapiens_hsa049660.84657670
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82167849
47Linoleic acid metabolism_Homo sapiens_hsa005910.81064094
48Viral myocarditis_Homo sapiens_hsa054160.79371622
49Olfactory transduction_Homo sapiens_hsa047400.77529167
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76942154
51Tryptophan metabolism_Homo sapiens_hsa003800.76875646
52Fanconi anemia pathway_Homo sapiens_hsa034600.76782535
53Purine metabolism_Homo sapiens_hsa002300.75878255
54Basal transcription factors_Homo sapiens_hsa030220.75115668
55Arachidonic acid metabolism_Homo sapiens_hsa005900.74552906
56Pyrimidine metabolism_Homo sapiens_hsa002400.74466263
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73000023
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.72812984
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71134174
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70232829
61N-Glycan biosynthesis_Homo sapiens_hsa005100.69957099
62Herpes simplex infection_Homo sapiens_hsa051680.68949062
63Shigellosis_Homo sapiens_hsa051310.67311159
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.66628590
65Nitrogen metabolism_Homo sapiens_hsa009100.65978781
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65546115
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64281436
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63902374
69Homologous recombination_Homo sapiens_hsa034400.62159275
70Malaria_Homo sapiens_hsa051440.61742282
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.56351362
72Retinol metabolism_Homo sapiens_hsa008300.56350496
73Base excision repair_Homo sapiens_hsa034100.55940413
74Salmonella infection_Homo sapiens_hsa051320.54840000
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52001828
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51843548
77Lysosome_Homo sapiens_hsa041420.51633143
78Metabolic pathways_Homo sapiens_hsa011000.50819507
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50760135
80Regulation of autophagy_Homo sapiens_hsa041400.50675653
81Glutathione metabolism_Homo sapiens_hsa004800.50604510
82Sulfur relay system_Homo sapiens_hsa041220.48742402
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47873717
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46338384
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45085333
86RNA degradation_Homo sapiens_hsa030180.43180170
87Phenylalanine metabolism_Homo sapiens_hsa003600.42486448
88Tyrosine metabolism_Homo sapiens_hsa003500.37556502
89Ovarian steroidogenesis_Homo sapiens_hsa049130.36607174
90Taste transduction_Homo sapiens_hsa047420.34794329
91Salivary secretion_Homo sapiens_hsa049700.33530106
92Selenocompound metabolism_Homo sapiens_hsa004500.32749098
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32319079
94Leishmaniasis_Homo sapiens_hsa051400.31871191
95Legionellosis_Homo sapiens_hsa051340.29542886
96Systemic lupus erythematosus_Homo sapiens_hsa053220.29292996
97Ether lipid metabolism_Homo sapiens_hsa005650.27902381
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27625246
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27503206
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21008574

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