RPSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ribosomal small subunit assembly (GO:0000028)7.65346452
2* viral transcription (GO:0019083)7.55650116
3* translational termination (GO:0006415)7.28249617
4ribosomal small subunit biogenesis (GO:0042274)6.52347527
5* translational elongation (GO:0006414)6.37645376
6maturation of SSU-rRNA (GO:0030490)6.37263697
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.07133744
8* protein targeting to ER (GO:0045047)5.92081472
9* cotranslational protein targeting to membrane (GO:0006613)5.90570113
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.87891625
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.64185184
12* cellular protein complex disassembly (GO:0043624)5.60965572
13* viral life cycle (GO:0019058)5.59448202
14* translational initiation (GO:0006413)5.54149092
15* protein localization to endoplasmic reticulum (GO:0070972)5.50560479
16ribosomal large subunit biogenesis (GO:0042273)5.05125484
17* protein complex disassembly (GO:0043241)5.05034022
18* macromolecular complex disassembly (GO:0032984)4.71153242
19* nuclear-transcribed mRNA catabolic process (GO:0000956)4.34744250
20DNA unwinding involved in DNA replication (GO:0006268)4.32380614
21DNA strand elongation involved in DNA replication (GO:0006271)4.20396880
22formation of translation preinitiation complex (GO:0001731)4.18574138
23* mRNA catabolic process (GO:0006402)4.14600553
24ribonucleoprotein complex biogenesis (GO:0022613)4.12737864
25DNA strand elongation (GO:0022616)4.00314543
26* RNA catabolic process (GO:0006401)3.99009421
27telomere maintenance via semi-conservative replication (GO:0032201)3.95417557
28* protein targeting to membrane (GO:0006612)3.89123534
29DNA replication initiation (GO:0006270)3.78803484
30establishment of integrated proviral latency (GO:0075713)3.75940612
31* translation (GO:0006412)3.74041712
32telomere maintenance via recombination (GO:0000722)3.45049100
33folic acid-containing compound biosynthetic process (GO:0009396)3.40708951
34protein localization to kinetochore (GO:0034501)3.39090365
35L-serine metabolic process (GO:0006563)3.38238399
36IMP biosynthetic process (GO:0006188)3.35910968
37protein complex localization (GO:0031503)3.32010384
38mitotic recombination (GO:0006312)3.29398208
39* rRNA processing (GO:0006364)3.27786010
40DNA deamination (GO:0045006)3.22129634
41* rRNA metabolic process (GO:0016072)3.17210827
42telomere maintenance via telomere lengthening (GO:0010833)3.15660480
43negative regulation of RNA splicing (GO:0033119)3.08083448
44DNA topological change (GO:0006265)3.07659096
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.05057940
46pore complex assembly (GO:0046931)3.03971533
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02100484
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02100484
49IMP metabolic process (GO:0046040)3.01876511
50nucleobase biosynthetic process (GO:0046112)2.98070916
51mitotic nuclear envelope disassembly (GO:0007077)2.97586695
52proline biosynthetic process (GO:0006561)2.96504804
53DNA replication checkpoint (GO:0000076)2.96283033
54protein localization to chromosome, centromeric region (GO:0071459)2.96227018
55cellular protein complex localization (GO:0034629)2.94907806
56ribosome biogenesis (GO:0042254)2.92604152
57establishment of viral latency (GO:0019043)2.89422329
58peptidyl-arginine omega-N-methylation (GO:0035247)2.86004808
59cellular component biogenesis (GO:0044085)2.85692528
60nucleobase-containing small molecule interconversion (GO:0015949)2.85497207
61histone arginine methylation (GO:0034969)2.85012523
62chromatin remodeling at centromere (GO:0031055)2.83942367
63mitotic sister chromatid cohesion (GO:0007064)2.83793489
64DNA duplex unwinding (GO:0032508)2.83455300
65CENP-A containing nucleosome assembly (GO:0034080)2.81504421
66DNA geometric change (GO:0032392)2.81153640
67spliceosomal tri-snRNP complex assembly (GO:0000244)2.80630463
68regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79905326
69tRNA aminoacylation for protein translation (GO:0006418)2.78554872
70negative regulation of mRNA processing (GO:0050686)2.77670220
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77283644
72* protein targeting (GO:0006605)2.74600928
73chromosome condensation (GO:0030261)2.74153166
74nuclear pore organization (GO:0006999)2.72191235
75nuclear envelope disassembly (GO:0051081)2.72183123
76membrane disassembly (GO:0030397)2.72183123
77DNA replication-dependent nucleosome assembly (GO:0006335)2.71847960
78DNA replication-dependent nucleosome organization (GO:0034723)2.71847960
79antigen processing and presentation of endogenous antigen (GO:0019883)2.71595072
80DNA synthesis involved in DNA repair (GO:0000731)2.71516915
81tRNA aminoacylation (GO:0043039)2.70675380
82amino acid activation (GO:0043038)2.70675380
83serine family amino acid biosynthetic process (GO:0009070)2.69289919
84positive regulation of chromosome segregation (GO:0051984)2.69029593
85pseudouridine synthesis (GO:0001522)2.68065001
86negative regulation of mRNA metabolic process (GO:1903312)2.67636321
87chromatin assembly (GO:0031497)2.66786424
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66592824
89DNA replication-independent nucleosome organization (GO:0034724)2.66326855
90DNA replication-independent nucleosome assembly (GO:0006336)2.66326855
91rRNA transcription (GO:0009303)2.65003172
92viral mRNA export from host cell nucleus (GO:0046784)2.64558745
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63940393
94regulation of translational elongation (GO:0006448)2.63884459
95nuclear pore complex assembly (GO:0051292)2.63668907
96spliceosomal snRNP assembly (GO:0000387)2.61866596
973-UTR-mediated mRNA stabilization (GO:0070935)2.61076787
98regulation of histone H3-K9 methylation (GO:0051570)2.59758311
99kinetochore organization (GO:0051383)2.59590485
100mitotic metaphase plate congression (GO:0007080)2.58339927
101translesion synthesis (GO:0019985)2.57535430
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57397489
103mRNA splicing, via spliceosome (GO:0000398)2.57397489
104purine nucleobase biosynthetic process (GO:0009113)2.56644013
105RNA splicing, via transesterification reactions (GO:0000375)2.56437531
106telomere maintenance (GO:0000723)2.56233773
107T cell apoptotic process (GO:0070231)2.54750181
108telomere organization (GO:0032200)2.54666494
109* establishment of protein localization to membrane (GO:0090150)2.53050379
110mitotic chromosome condensation (GO:0007076)2.51514910
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50377575
112chromatin assembly or disassembly (GO:0006333)2.46977045
113* establishment of protein localization to organelle (GO:0072594)2.46808271
114spliceosomal complex assembly (GO:0000245)2.45187071
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41582153
116termination of RNA polymerase II transcription (GO:0006369)2.40459354
117dosage compensation (GO:0007549)2.40007400
118regulation of protein heterodimerization activity (GO:0043497)2.40004962
119mitotic sister chromatid segregation (GO:0000070)2.39374600
120ribosome assembly (GO:0042255)2.38946545
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.38697617
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38697617
123heterochromatin organization (GO:0070828)2.38084575
124regulation of translational fidelity (GO:0006450)2.37645804
125* ncRNA processing (GO:0034470)2.37407604
126metaphase plate congression (GO:0051310)2.35269023
127* gene expression (GO:0010467)2.34849803
128sister chromatid segregation (GO:0000819)2.34434233
129DNA conformation change (GO:0071103)2.34002734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.92306338
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.10497401
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80119956
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44028409
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09907668
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99046777
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70263161
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70229670
9MYC_22102868_ChIP-Seq_BL_Human2.54638153
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49721830
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48932782
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.48672781
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.39839642
14* XRN2_22483619_ChIP-Seq_HELA_Human2.33341517
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.30567081
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.23994332
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16166516
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11319708
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07337534
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06188270
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03986039
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00653553
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00326455
24VDR_23849224_ChIP-Seq_CD4+_Human1.99202635
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96198709
26VDR_21846776_ChIP-Seq_THP-1_Human1.94891339
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88377522
28FOXP3_21729870_ChIP-Seq_TREG_Human1.84892046
29TTF2_22483619_ChIP-Seq_HELA_Human1.79146697
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78365278
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.76532228
32CIITA_25753668_ChIP-Seq_RAJI_Human1.75234600
33DCP1A_22483619_ChIP-Seq_HELA_Human1.73987946
34ZNF263_19887448_ChIP-Seq_K562_Human1.73475791
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73300659
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65226465
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63057174
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60791978
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58830592
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57471902
41GABP_19822575_ChIP-Seq_HepG2_Human1.54435257
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52906354
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50979512
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50203054
45* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49258950
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48532803
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44195304
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43461636
49SCL_19346495_ChIP-Seq_HPC-7_Human1.43094747
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42653039
51* ELK1_19687146_ChIP-ChIP_HELA_Human1.42313059
52* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41437787
53AR_21909140_ChIP-Seq_LNCAP_Human1.40921769
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40180631
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38435379
56SPI1_23547873_ChIP-Seq_NB4_Human1.36475536
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36107741
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35611465
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33635894
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.31326825
61KDM5A_27292631_Chip-Seq_BREAST_Human1.30754187
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30564530
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29229571
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.29066112
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27147022
66* MAF_26560356_Chip-Seq_TH1_Human1.26495643
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24634106
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24221751
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23507234
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22802602
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21162843
72* UTX_26944678_Chip-Seq_JUKART_Human1.20525151
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19975578
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16675398
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16201122
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13663893
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.13248809
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11695749
79TFEB_21752829_ChIP-Seq_HELA_Human1.11521259
80MYB_26560356_Chip-Seq_TH2_Human1.11346432
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11337200
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10329822
83TCF7_22412390_ChIP-Seq_EML_Mouse1.09722404
84VDR_24763502_ChIP-Seq_THP-1_Human1.09711258
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08631819
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08455734
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.07655187
88* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07538444
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07152323
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06395449
91MYB_26560356_Chip-Seq_TH1_Human1.06323096
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05560582
93MAF_26560356_Chip-Seq_TH2_Human1.05166765
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.04486579
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03726935
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01929319
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01751748
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01448188
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00646271
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00100338
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99933862
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99916627
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.99213697
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.99000283
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98606983
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98482248
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97502271
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97494291
109* CHD1_26751641_Chip-Seq_LNCaP_Human0.97246240
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.97027012
111* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96583901
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96555387
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96377519
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.93884237
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93785893
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93106532
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93106532
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93106532
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93072893
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92444849
121RACK7_27058665_Chip-Seq_MCF-7_Human0.92194196
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.92100151
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91025873
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90234107
125MYC_18940864_ChIP-ChIP_HL60_Human0.90105235
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89682213
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.89544092
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89161036
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88231757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.92527136
2MP0010094_abnormal_chromosome_stability3.35431956
3MP0002396_abnormal_hematopoietic_system3.28662174
4MP0004957_abnormal_blastocyst_morpholog3.26650178
5MP0003111_abnormal_nucleus_morphology3.10285573
6MP0003077_abnormal_cell_cycle3.08660888
7MP0008057_abnormal_DNA_replication2.57923698
8MP0010030_abnormal_orbit_morphology2.46900981
9MP0004808_abnormal_hematopoietic_stem2.42700891
10MP0009379_abnormal_foot_pigmentation2.39353472
11MP0010352_gastrointestinal_tract_polyps2.35918162
12MP0003763_abnormal_thymus_physiology2.31102037
13MP0008007_abnormal_cellular_replicative2.27677865
14MP0008058_abnormal_DNA_repair2.27351283
15MP0000490_abnormal_crypts_of2.19355900
16MP0001835_abnormal_antigen_presentation2.07227058
17MP0000685_abnormal_immune_system2.01760862
18MP0005397_hematopoietic_system_phenotyp1.95524657
19MP0001545_abnormal_hematopoietic_system1.95524657
20MP0009333_abnormal_splenocyte_physiolog1.93647985
21MP0002398_abnormal_bone_marrow1.89398489
22MP0000350_abnormal_cell_proliferation1.72339609
23MP0000703_abnormal_thymus_morphology1.68767404
24MP0001730_embryonic_growth_arrest1.67832623
25MP0010307_abnormal_tumor_latency1.66277994
26MP0001800_abnormal_humoral_immune1.66072042
27MP0002722_abnormal_immune_system1.64239534
28MP0006292_abnormal_olfactory_placode1.63847913
29MP0008932_abnormal_embryonic_tissue1.61648816
30MP0009278_abnormal_bone_marrow1.60445973
31MP0009672_abnormal_birth_weight1.57103783
32MP0004185_abnormal_adipocyte_glucose1.56508045
33MP0000689_abnormal_spleen_morphology1.56011053
34MP0002166_altered_tumor_susceptibility1.53741325
35MP0002019_abnormal_tumor_incidence1.53415789
36MP0002163_abnormal_gland_morphology1.52767767
37MP0005671_abnormal_response_to1.50508545
38MP0003123_paternal_imprinting1.48586779
39MP0004233_abnormal_muscle_weight1.48509829
40MP0009053_abnormal_anal_canal1.47594646
41MP0002420_abnormal_adaptive_immunity1.47512189
42MP0002452_abnormal_antigen_presenting1.46710307
43MP0000716_abnormal_immune_system1.45773134
44* MP0002429_abnormal_blood_cell1.45365088
45MP0001819_abnormal_immune_cell1.45001387
46MP0000566_synostosis1.40528247
47MP0002697_abnormal_eye_size1.38934434
48MP0002796_impaired_skin_barrier1.37895595
49MP0000313_abnormal_cell_death1.37170993
50MP0001873_stomach_inflammation1.36846281
51MP0010234_abnormal_vibrissa_follicle1.36236510
52MP0003786_premature_aging1.35677344
53MP0010155_abnormal_intestine_physiology1.34347134
54MP0006054_spinal_hemorrhage1.34328070
55MP0000858_altered_metastatic_potential1.33938318
56MP0005174_abnormal_tail_pigmentation1.32319476
57MP0002723_abnormal_immune_serum1.31952221
58MP0000465_gastrointestinal_hemorrhage1.28693048
59MP0009785_altered_susceptibility_to1.27144395
60MP0002405_respiratory_system_inflammati1.25051808
61MP0002006_tumorigenesis1.24916061
62MP0005025_abnormal_response_to1.24906550
63* MP0002080_prenatal_lethality1.22374651
64MP0001697_abnormal_embryo_size1.21409573
65MP0003567_abnormal_fetal_cardiomyocyte1.21224680
66MP0003436_decreased_susceptibility_to1.19523718
67MP0005000_abnormal_immune_tolerance1.19327572
68MP0003937_abnormal_limbs/digits/tail_de1.18942398
69MP0000428_abnormal_craniofacial_morphol1.18658625
70MP0003941_abnormal_skin_development1.18373186
71MP0005076_abnormal_cell_differentiation1.16881019
72MP0000678_abnormal_parathyroid_gland1.16613250
73MP0001672_abnormal_embryogenesis/_devel1.16463130
74MP0005380_embryogenesis_phenotype1.16463130
75MP0002086_abnormal_extraembryonic_tissu1.14567828
76MP0001849_ear_inflammation1.14054592
77MP0005387_immune_system_phenotype1.12696406
78MP0001790_abnormal_immune_system1.12696406
79MP0000358_abnormal_cell_content/1.11498316
80MP0005464_abnormal_platelet_physiology1.10541828
81MP0001348_abnormal_lacrimal_gland1.10450264
82MP0003984_embryonic_growth_retardation1.10304198
83MP0001346_abnormal_lacrimal_gland1.09875007
84MP0002088_abnormal_embryonic_growth/wei1.08437462
85MP0006035_abnormal_mitochondrial_morpho1.08308954
86MP0003866_abnormal_defecation1.06394771
87MP0001853_heart_inflammation1.05995414
88MP0002111_abnormal_tail_morphology1.05711625
89* MP0004197_abnormal_fetal_growth/weight/1.02192387
90MP0002085_abnormal_embryonic_tissue1.01613065
91MP0005023_abnormal_wound_healing0.99818831
92MP0002084_abnormal_developmental_patter0.99466572
93MP0001661_extended_life_span0.99217250
94MP0003300_gastrointestinal_ulcer0.98902586
95MP0004858_abnormal_nervous_system0.98374637
96MP0002095_abnormal_skin_pigmentation0.98032360
97MP0002089_abnormal_postnatal_growth/wei0.96964840
98MP0003566_abnormal_cell_adhesion0.96087938
99MP0001145_abnormal_male_reproductive0.95702967
100MP0002148_abnormal_hypersensitivity_rea0.95313592
101MP0002092_abnormal_eye_morphology0.94786095
102MP0002009_preneoplasia0.93494334
103MP0003718_maternal_effect0.93074360
104MP0001286_abnormal_eye_development0.91665464
105MP0000477_abnormal_intestine_morphology0.91320890
106MP0005451_abnormal_body_composition0.91051510
107MP0003890_abnormal_embryonic-extraembry0.90962723
108MP0003806_abnormal_nucleotide_metabolis0.90229430
109MP0002132_abnormal_respiratory_system0.90150632
110MP0005075_abnormal_melanosome_morpholog0.89700127
111MP0000049_abnormal_middle_ear0.89532619
112MP0002877_abnormal_melanocyte_morpholog0.87532819
113MP0000762_abnormal_tongue_morphology0.86926619
114MP0003705_abnormal_hypodermis_morpholog0.86010796
115MP0003861_abnormal_nervous_system0.85443487
116MP0001293_anophthalmia0.84598865
117MP0004264_abnormal_extraembryonic_tissu0.83922419
118MP0002160_abnormal_reproductive_system0.82736765
119MP0003303_peritoneal_inflammation0.82310203
120MP0003385_abnormal_body_wall0.81333406
121MP0003448_altered_tumor_morphology0.80261238
122MP0002419_abnormal_innate_immunity0.79222841
123MP0003942_abnormal_urinary_system0.78018314
124MP0003136_yellow_coat_color0.77948763
125MP0005384_cellular_phenotype0.76895135
126MP0004947_skin_inflammation0.76888815
127MP0001845_abnormal_inflammatory_respons0.76572631
128MP0002249_abnormal_larynx_morphology0.76522217
129MP0002938_white_spotting0.75906124
130MP0001929_abnormal_gametogenesis0.74948890
131MP0000653_abnormal_sex_gland0.73860651
132MP0009703_decreased_birth_body0.73835015
133MP0001915_intracranial_hemorrhage0.71698172
134MP0000733_abnormal_muscle_development0.70506558
135MP0003453_abnormal_keratinocyte_physiol0.69836930
136MP0003755_abnormal_palate_morphology0.69267454
137MP0008260_abnormal_autophagy0.68489413
138MP0002114_abnormal_axial_skeleton0.67301929
139MP0005501_abnormal_skin_physiology0.67210287
140MP0000537_abnormal_urethra_morphology0.66774185
141MP0000432_abnormal_head_morphology0.66756227
142MP0005257_abnormal_intraocular_pressure0.66658073
143MP0003315_abnormal_perineum_morphology0.66598258
144MP0003943_abnormal_hepatobiliary_system0.66521701
145MP0008877_abnormal_DNA_methylation0.65982278
146MP0002233_abnormal_nose_morphology0.65553235
147MP0002933_joint_inflammation0.64148552
148MP0003121_genomic_imprinting0.62215033
149MP0002210_abnormal_sex_determination0.58514287
150MP0005621_abnormal_cell_physiology0.58079694
151MP0003186_abnormal_redox_activity0.56358245
152MP0009931_abnormal_skin_appearance0.56096188

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.93246921
2Abnormality of cells of the erythroid lineage (HP:0012130)6.74195087
3Abnormal number of erythroid precursors (HP:0012131)6.25641707
4Pallor (HP:0000980)4.40196451
5Macrocytic anemia (HP:0001972)4.38917484
6Colon cancer (HP:0003003)3.94733635
7* Thrombocytosis (HP:0001894)3.68025897
8Aplastic anemia (HP:0001915)3.49800514
911 pairs of ribs (HP:0000878)3.17896535
10IgM deficiency (HP:0002850)3.08053470
11Microvesicular hepatic steatosis (HP:0001414)3.00931791
12Progressive muscle weakness (HP:0003323)2.89772171
13Absent thumb (HP:0009777)2.76140105
14Abnormality of reticulocytes (HP:0004312)2.71659327
15Duplication of thumb phalanx (HP:0009942)2.67364439
16Myelodysplasia (HP:0002863)2.67132538
17Selective tooth agenesis (HP:0001592)2.66989653
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63305740
19Elevated erythrocyte sedimentation rate (HP:0003565)2.63134551
20Chronic otitis media (HP:0000389)2.60018378
21Basal cell carcinoma (HP:0002671)2.58314347
22Recurrent bronchitis (HP:0002837)2.56397795
23Oral leukoplakia (HP:0002745)2.55414100
24Birth length less than 3rd percentile (HP:0003561)2.51627360
25Petechiae (HP:0000967)2.48858952
26Amaurosis fugax (HP:0100576)2.48856944
27Horseshoe kidney (HP:0000085)2.40606187
28Abnormality of T cells (HP:0002843)2.38758031
29Chromsome breakage (HP:0040012)2.36867106
30Abnormality of T cell physiology (HP:0011840)2.36824053
31Medulloblastoma (HP:0002885)2.35116979
32Poikiloderma (HP:0001029)2.34116474
33Progressive external ophthalmoplegia (HP:0000590)2.33755763
34Ependymoma (HP:0002888)2.30420718
35Missing ribs (HP:0000921)2.30133663
36Broad distal phalanx of finger (HP:0009836)2.29384108
37Recurrent viral infections (HP:0004429)2.28850925
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.26865952
39Lymphoma (HP:0002665)2.26686503
40High anterior hairline (HP:0009890)2.24400427
41Multiple enchondromatosis (HP:0005701)2.18725687
42Abnormality of chromosome stability (HP:0003220)2.14183846
43Ectopic kidney (HP:0000086)2.13306457
44Insomnia (HP:0100785)2.12720989
45Abnormality of the fingertips (HP:0001211)2.10991134
46Deep palmar crease (HP:0006191)2.10287384
47Abnormal hemoglobin (HP:0011902)2.08323532
48Partial duplication of thumb phalanx (HP:0009944)2.07406649
49Cellulitis (HP:0100658)2.07385698
50Microretrognathia (HP:0000308)2.06187489
51Facial cleft (HP:0002006)2.05075151
52Short middle phalanx of the 5th finger (HP:0004220)2.04915060
53Neoplasm of the pancreas (HP:0002894)2.04141238
54T lymphocytopenia (HP:0005403)2.03744922
55Long palpebral fissure (HP:0000637)2.02932361
56Abnormality of the preputium (HP:0100587)2.02578149
57Trismus (HP:0000211)2.02382574
58Panhypogammaglobulinemia (HP:0003139)2.02265729
59Nasal polyposis (HP:0100582)2.00347614
60Overriding aorta (HP:0002623)1.98735872
61Agnosia (HP:0010524)1.98556005
62Abnormality of cells of the lymphoid lineage (HP:0012140)1.97698711
63Squamous cell carcinoma (HP:0002860)1.94722716
64Abnormality of T cell number (HP:0011839)1.94156223
65Prolonged bleeding time (HP:0003010)1.92800912
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92537393
67Acute lymphatic leukemia (HP:0006721)1.91493826
68Partial duplication of the phalanx of hand (HP:0009999)1.91370056
69Depressed nasal ridge (HP:0000457)1.91246690
70Abnormal number of incisors (HP:0011064)1.90242910
71Meckel diverticulum (HP:0002245)1.88878724
72Rectal prolapse (HP:0002035)1.88870386
73Abnormality of the nasal mucosa (HP:0000433)1.88089010
74Abnormality of cochlea (HP:0000375)1.86969140
75Lymphopenia (HP:0001888)1.85587640
76Proximal placement of thumb (HP:0009623)1.84986300
77Rhabdomyosarcoma (HP:0002859)1.84951469
78Pancytopenia (HP:0001876)1.84947791
79High pitched voice (HP:0001620)1.84346932
80Premature graying of hair (HP:0002216)1.84346299
81Gastrointestinal inflammation (HP:0004386)1.84226479
82Deviation of the thumb (HP:0009603)1.84001257
83Abnormality of DNA repair (HP:0003254)1.83265740
84Thick lower lip vermilion (HP:0000179)1.83086434
85Degeneration of anterior horn cells (HP:0002398)1.82679656
86Abnormality of the anterior horn cell (HP:0006802)1.82679656
87Patellar aplasia (HP:0006443)1.82505686
88Absent radius (HP:0003974)1.82040356
89Migraine (HP:0002076)1.80574186
90Rough bone trabeculation (HP:0100670)1.80030346
91Ankyloglossia (HP:0010296)1.80000218
92Atresia of the external auditory canal (HP:0000413)1.79930156
93Recurrent fungal infections (HP:0002841)1.79510516
94Abnormality of the ileum (HP:0001549)1.77771458
95Bone marrow hypocellularity (HP:0005528)1.77594486
96Cutaneous melanoma (HP:0012056)1.75451244
97Abnormality of the calcaneus (HP:0008364)1.75443668
98Premature ovarian failure (HP:0008209)1.74473045
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.74026066
100Premature skin wrinkling (HP:0100678)1.73876295
101Myositis (HP:0100614)1.73870772
102Cortical dysplasia (HP:0002539)1.73436930
103Entropion (HP:0000621)1.73089648
104Aplasia/Hypoplasia of the thymus (HP:0010515)1.72709703
105Aplasia/Hypoplasia of the patella (HP:0006498)1.72454264
106Cleft eyelid (HP:0000625)1.72299397
107Tracheoesophageal fistula (HP:0002575)1.71478217
108Abnormality of the phalanges of the hallux (HP:0010057)1.70490939
109Glossoptosis (HP:0000162)1.70332092
110Increased nuchal translucency (HP:0010880)1.70324836
111Cafe-au-lait spot (HP:0000957)1.70167607
112Optic nerve coloboma (HP:0000588)1.69646537
113Abnormality of the umbilical cord (HP:0010881)1.69543810
114Breast hypoplasia (HP:0003187)1.69434808
115Abnormality of B cell number (HP:0010975)1.69230323
116B lymphocytopenia (HP:0010976)1.69230323
117Increased density of long bones (HP:0006392)1.68847183
118Triphalangeal thumb (HP:0001199)1.68417215
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.68219169
120Aplasia involving forearm bones (HP:0009822)1.68041321
121Absent forearm bone (HP:0003953)1.68041321
122Abnormal platelet volume (HP:0011876)1.68002358
123Renal duplication (HP:0000075)1.67760787
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67758637
125Hyperacusis (HP:0010780)1.67664157
126Microglossia (HP:0000171)1.67262906
127Stenosis of the external auditory canal (HP:0000402)1.65596772
128Cellular immunodeficiency (HP:0005374)1.65312176
129Ragged-red muscle fibers (HP:0003200)1.65050219
130Metaphyseal cupping (HP:0003021)1.64736002
131Acute myeloid leukemia (HP:0004808)1.64539848
132Small intestinal stenosis (HP:0012848)1.64408341
133Duodenal stenosis (HP:0100867)1.64408341
134Papilloma (HP:0012740)1.64363406
135Verrucae (HP:0200043)1.64363406
136Inflammation of the large intestine (HP:0002037)1.62819570
137Abnormality of the carotid arteries (HP:0005344)1.62763964
138Agammaglobulinemia (HP:0004432)1.62101111
139Carpal bone hypoplasia (HP:0001498)1.61986415
140Prominent nose (HP:0000448)1.61465537
141Abnormal lung lobation (HP:0002101)1.61393027
142Choanal atresia (HP:0000453)1.61053841
143Nephroblastoma (Wilms tumor) (HP:0002667)1.60234450
144Hypoplastic pelvis (HP:0008839)1.58817560
145Short thumb (HP:0009778)1.58648058
146Duplicated collecting system (HP:0000081)1.58432031
147Elfin facies (HP:0004428)1.58416212
148Hypoplasia of the radius (HP:0002984)1.55056549
149Gout (HP:0001997)1.54078260
150Abnormality of the parietal bone (HP:0002696)1.53826509
151Syringomyelia (HP:0003396)1.53313199
152Spinal cord lesions (HP:0100561)1.53313199
153Abdominal situs inversus (HP:0003363)1.52876972
154Abnormality of abdominal situs (HP:0011620)1.52876972
155Respiratory difficulties (HP:0002880)1.52272547
156Disproportionate tall stature (HP:0001519)1.50002597
157Abnormality of the thoracic spine (HP:0100711)1.45873328
158Abnormality of the renal collecting system (HP:0004742)1.45291583
159Overlapping toe (HP:0001845)1.44541150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.82740126
2NME23.78909702
3EEF2K3.72242999
4CDC72.94504570
5MAP4K12.87626463
6PBK2.84527821
7WEE12.60498342
8PKN22.58198549
9TLK12.45642015
10RPS6KB22.39764819
11NEK22.33129427
12PASK2.31705737
13BUB12.31513200
14VRK22.27691739
15TGFBR12.24989972
16MAP3K102.15077205
17LRRK22.03902868
18RPS6KA41.93805318
19FLT31.87784869
20ICK1.83111847
21EIF2AK11.80058908
22PRPF4B1.78397212
23TAF11.70463256
24TSSK61.69774027
25TRIB31.57649229
26BRAF1.46929207
27SRPK11.44389068
28BTK1.44267791
29STK101.44129976
30DYRK31.42113059
31CDK41.40602794
32AURKB1.37920214
33CDK71.37821444
34SCYL21.37713758
35PIM21.34429031
36ATR1.34258806
37JAK31.31697409
38PIM11.28771278
39VRK11.26339872
40IRAK31.23550627
41ACVR1B1.22809405
42MAP3K81.22135572
43MKNK11.21942966
44BRSK21.20846007
45MAP2K31.20550435
46ARAF1.19272108
47ZAP701.18645886
48PLK11.13576282
49TTK1.12787692
50KIT1.12330709
51STK41.10326756
52CDK121.05278945
53ILK1.00399940
54TESK21.00330832
55TEC0.98499853
56GRK60.98316199
57CLK10.98116978
58PAK40.97852264
59BLK0.95107630
60CSF1R0.91300332
61STK160.87543441
62TYK20.85807522
63ZAK0.85801260
64NME10.85135835
65ALK0.84526697
66LMTK20.84264500
67IKBKB0.84060611
68CDK190.82924419
69CHEK10.81325120
70MKNK20.79787121
71NEK10.77679528
72EIF2AK30.76608269
73KSR20.76519369
74TBK10.75028063
75LATS20.73911198
76CDK60.71523800
77TXK0.68999476
78MAPKAPK30.68294392
79MAP3K90.67829829
80SYK0.66859603
81CHEK20.66389614
82SIK10.65343944
83CDK80.64549465
84RPS6KA50.63064642
85MST1R0.62934324
86STK240.62577803
87MAP3K110.61773124
88CSNK2A20.61548304
89AURKA0.61365956
90TYRO30.61105632
91MTOR0.61065722
92AKT20.59475697
93ATM0.59386923
94LCK0.59000878
95CDK20.58633536
96RPS6KA60.58309005
97PTK60.58008914
98BRSK10.57287177
99RPS6KL10.55724980
100RPS6KC10.55724980
101PAK20.55598667
102KDR0.54421971
103NEK90.53349664
104IKBKE0.53194857
105CDK10.52514603
106BMX0.52512026
107MST40.51551559
108CHUK0.49991767
109FGFR40.49597075
110NLK0.49072495
111PRKD30.47921453
112TAOK20.47134313
113IRAK40.46762905
114LYN0.46276422
115STK30.46038117
116EPHA20.45997998
117CSNK2A10.44572542
118PAK10.44448096
119CDK11A0.43242734
120PLK40.43057010
121ITK0.41918350
122TTN0.41499699
123RPS6KA10.40664940
124MAPKAPK20.40601928
125PLK30.40193937
126CDK90.39791307
127BRD40.39557565
128RAF10.39337733
129HCK0.39243047
130ERN10.38682154
131PRKCI0.38661734
132MAP2K20.38589639
133DAPK30.38008187
134MELK0.37160956
135RPS6KB10.33264896
136PDGFRA0.31836179
137ERBB40.29816743
138IRAK20.29336807

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.67739061
2DNA replication_Homo sapiens_hsa030304.59340702
3Mismatch repair_Homo sapiens_hsa034303.71699888
4Spliceosome_Homo sapiens_hsa030402.93608464
5Base excision repair_Homo sapiens_hsa034102.79843683
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67492764
7Homologous recombination_Homo sapiens_hsa034402.58212893
8Nucleotide excision repair_Homo sapiens_hsa034202.42177864
9One carbon pool by folate_Homo sapiens_hsa006702.38330515
10RNA transport_Homo sapiens_hsa030132.35278656
11RNA polymerase_Homo sapiens_hsa030202.18382328
12Proteasome_Homo sapiens_hsa030502.11309777
13Cell cycle_Homo sapiens_hsa041102.09154440
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02621578
15Pyrimidine metabolism_Homo sapiens_hsa002401.95402089
16Non-homologous end-joining_Homo sapiens_hsa034501.88759961
17Primary immunodeficiency_Homo sapiens_hsa053401.70733223
18Fanconi anemia pathway_Homo sapiens_hsa034601.65935543
19Antigen processing and presentation_Homo sapiens_hsa046121.54322037
20RNA degradation_Homo sapiens_hsa030181.53895391
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50000484
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48877702
23p53 signaling pathway_Homo sapiens_hsa041151.43787719
24mRNA surveillance pathway_Homo sapiens_hsa030151.37620840
25Herpes simplex infection_Homo sapiens_hsa051681.35343642
26Systemic lupus erythematosus_Homo sapiens_hsa053221.34893036
27Carbon metabolism_Homo sapiens_hsa012001.31209609
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.29666376
29Basal transcription factors_Homo sapiens_hsa030221.17080376
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16262325
31Epstein-Barr virus infection_Homo sapiens_hsa051691.12535355
32Viral carcinogenesis_Homo sapiens_hsa052031.08066160
33Measles_Homo sapiens_hsa051621.05110371
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.03684879
35HTLV-I infection_Homo sapiens_hsa051660.98084433
36Sulfur relay system_Homo sapiens_hsa041220.93310306
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91090278
38Small cell lung cancer_Homo sapiens_hsa052220.89629329
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89409412
40Purine metabolism_Homo sapiens_hsa002300.89201858
41Legionellosis_Homo sapiens_hsa051340.88684103
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.88124406
43B cell receptor signaling pathway_Homo sapiens_hsa046620.87971419
44Hematopoietic cell lineage_Homo sapiens_hsa046400.87759701
45Apoptosis_Homo sapiens_hsa042100.87699267
46Chronic myeloid leukemia_Homo sapiens_hsa052200.87469046
47Vitamin B6 metabolism_Homo sapiens_hsa007500.87326539
48Acute myeloid leukemia_Homo sapiens_hsa052210.83382237
49Huntingtons disease_Homo sapiens_hsa050160.83123918
50Leishmaniasis_Homo sapiens_hsa051400.82473838
51Pyruvate metabolism_Homo sapiens_hsa006200.77560926
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77036776
53Hepatitis B_Homo sapiens_hsa051610.76976133
54Thyroid cancer_Homo sapiens_hsa052160.76476376
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74802491
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73442645
57Pentose phosphate pathway_Homo sapiens_hsa000300.72646609
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72193686
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71002529
60Shigellosis_Homo sapiens_hsa051310.69678697
61Parkinsons disease_Homo sapiens_hsa050120.68794007
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.67340012
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.66740561
64Galactose metabolism_Homo sapiens_hsa000520.66666387
65MicroRNAs in cancer_Homo sapiens_hsa052060.64762091
66Hippo signaling pathway_Homo sapiens_hsa043900.63868199
67Fructose and mannose metabolism_Homo sapiens_hsa000510.63030988
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61896937
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61570593
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61201712
71Influenza A_Homo sapiens_hsa051640.61152409
72Prostate cancer_Homo sapiens_hsa052150.60073339
73T cell receptor signaling pathway_Homo sapiens_hsa046600.59894707
74Allograft rejection_Homo sapiens_hsa053300.59679393
75Notch signaling pathway_Homo sapiens_hsa043300.59317158
76Colorectal cancer_Homo sapiens_hsa052100.57202438
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57080924
78N-Glycan biosynthesis_Homo sapiens_hsa005100.56056710
79Toxoplasmosis_Homo sapiens_hsa051450.55640560
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54787079
81Folate biosynthesis_Homo sapiens_hsa007900.54368418
82Protein export_Homo sapiens_hsa030600.53973499
83Endometrial cancer_Homo sapiens_hsa052130.53689596
84Glutathione metabolism_Homo sapiens_hsa004800.53658585
85Viral myocarditis_Homo sapiens_hsa054160.52496932
86Hedgehog signaling pathway_Homo sapiens_hsa043400.52248498
87Wnt signaling pathway_Homo sapiens_hsa043100.52148534
88Selenocompound metabolism_Homo sapiens_hsa004500.51053642
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51029049
90Non-small cell lung cancer_Homo sapiens_hsa052230.50714751
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50043766
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.50023864
93Oxidative phosphorylation_Homo sapiens_hsa001900.47577580
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47442710
95Melanoma_Homo sapiens_hsa052180.46622081
96Osteoclast differentiation_Homo sapiens_hsa043800.46006773
97Alcoholism_Homo sapiens_hsa050340.45040851
98Bladder cancer_Homo sapiens_hsa052190.44754902
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44666922
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44645907
101Pancreatic cancer_Homo sapiens_hsa052120.42271974
102Platelet activation_Homo sapiens_hsa046110.42167937
103HIF-1 signaling pathway_Homo sapiens_hsa040660.40626782
104Asthma_Homo sapiens_hsa053100.40074797
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.39909114
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39765253
107Adherens junction_Homo sapiens_hsa045200.39552883
108Lysine degradation_Homo sapiens_hsa003100.39013700
109Pathways in cancer_Homo sapiens_hsa052000.38704134
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38421478
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37705811
112TNF signaling pathway_Homo sapiens_hsa046680.37184110
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36905989
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36606164
115ErbB signaling pathway_Homo sapiens_hsa040120.36309314
116Graft-versus-host disease_Homo sapiens_hsa053320.36172718
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36166358
118VEGF signaling pathway_Homo sapiens_hsa043700.34803460
119Biosynthesis of amino acids_Homo sapiens_hsa012300.34555610
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33598707
121Basal cell carcinoma_Homo sapiens_hsa052170.32833539
122mTOR signaling pathway_Homo sapiens_hsa041500.32266525
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30494291
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30372393
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30242911
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30183475
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29995553
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29708809
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.29253302
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28512883
131Arginine and proline metabolism_Homo sapiens_hsa003300.28275054
132Renal cell carcinoma_Homo sapiens_hsa052110.27876123
133Oocyte meiosis_Homo sapiens_hsa041140.27441630
134Metabolic pathways_Homo sapiens_hsa011000.27140318
135Pertussis_Homo sapiens_hsa051330.26513308
136Proteoglycans in cancer_Homo sapiens_hsa052050.26468918
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25785991
138Alzheimers disease_Homo sapiens_hsa050100.24545094

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