RPSAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.35523585
2viral transcription (GO:0019083)7.51015369
3translational termination (GO:0006415)7.14633011
4translational elongation (GO:0006414)6.14645842
5NADH metabolic process (GO:0006734)5.89309836
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.80677300
7protein targeting to ER (GO:0045047)5.74171173
8cotranslational protein targeting to membrane (GO:0006613)5.72444898
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.60680109
10viral life cycle (GO:0019058)5.57065474
11cellular protein complex disassembly (GO:0043624)5.52111400
12ribosomal large subunit biogenesis (GO:0042273)5.48893177
13protein localization to endoplasmic reticulum (GO:0070972)5.40736659
14behavioral response to nicotine (GO:0035095)5.36867035
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.32007455
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.03425235
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.61192643
18protein complex disassembly (GO:0043241)4.59373940
19ribonucleoprotein complex biogenesis (GO:0022613)4.47927552
20translational initiation (GO:0006413)4.38277513
21protein import into peroxisome matrix (GO:0016558)4.35076950
22water-soluble vitamin biosynthetic process (GO:0042364)4.30093797
23macromolecular complex disassembly (GO:0032984)4.27373268
24ATP synthesis coupled proton transport (GO:0015986)4.22676318
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.22676318
26DNA deamination (GO:0045006)4.02029780
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00753839
28positive regulation of Notch signaling pathway (GO:0045747)3.97235670
29cellular component biogenesis (GO:0044085)3.91905543
30negative regulation of Ras GTPase activity (GO:0034261)3.90497004
31regulation of G0 to G1 transition (GO:0070316)3.86273156
32protein targeting to membrane (GO:0006612)3.79272069
33protein neddylation (GO:0045116)3.77498947
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74378447
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.74378447
36NADH dehydrogenase complex assembly (GO:0010257)3.74378447
37RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.73470830
38respiratory electron transport chain (GO:0022904)3.64462421
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61879230
40electron transport chain (GO:0022900)3.60279626
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.53684032
42activated T cell proliferation (GO:0050798)3.50516858
43regulation of rhodopsin mediated signaling pathway (GO:0022400)3.45457182
44translation (GO:0006412)3.39361999
45protein complex biogenesis (GO:0070271)3.37095708
46GMP metabolic process (GO:0046037)3.35590247
47mRNA catabolic process (GO:0006402)3.34705136
48phosphorylated carbohydrate dephosphorylation (GO:0046838)3.34549985
49inositol phosphate dephosphorylation (GO:0046855)3.34549985
502-oxoglutarate metabolic process (GO:0006103)3.33834352
51protein polyglutamylation (GO:0018095)3.31311250
52regulation of sister chromatid cohesion (GO:0007063)3.26360496
53maturation of SSU-rRNA (GO:0030490)3.25046816
54primary alcohol catabolic process (GO:0034310)3.24795893
55kidney morphogenesis (GO:0060993)3.17957328
56mitochondrial respiratory chain complex assembly (GO:0033108)3.15278297
57rhodopsin mediated signaling pathway (GO:0016056)3.13892654
58regulation of energy homeostasis (GO:2000505)3.13469174
59inositol phosphate catabolic process (GO:0071545)3.10002169
60RNA catabolic process (GO:0006401)3.03971879
61transmission of nerve impulse (GO:0019226)2.99330293
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89894259
63positive regulation of RNA splicing (GO:0033120)2.85044163
64rRNA processing (GO:0006364)2.84524306
65negative regulation of reactive oxygen species metabolic process (GO:2000378)2.79789856
66purine-containing compound salvage (GO:0043101)2.76944183
67rRNA metabolic process (GO:0016072)2.76565221
68hydrogen ion transmembrane transport (GO:1902600)2.64825831
69establishment of protein localization to membrane (GO:0090150)2.64468216
70negative regulation of response to food (GO:0032096)2.62941557
71negative regulation of appetite (GO:0032099)2.62941557
72nonmotile primary cilium assembly (GO:0035058)2.61812492
73intracellular protein transmembrane import (GO:0044743)2.60551093
74response to muscle activity (GO:0014850)2.59974337
75pseudouridine synthesis (GO:0001522)2.59764381
76negative regulation of phagocytosis (GO:0050765)2.55950541
77heart trabecula morphogenesis (GO:0061384)2.55698440
78protein targeting to peroxisome (GO:0006625)2.54528557
79establishment of protein localization to peroxisome (GO:0072663)2.54528557
80protein localization to peroxisome (GO:0072662)2.54528557
81T cell migration (GO:0072678)2.52849050
82histone H4 deacetylation (GO:0070933)2.51441024
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.49688232
84glyoxylate metabolic process (GO:0046487)2.46555199
85DNA synthesis involved in DNA repair (GO:0000731)2.45004076
86adaptation of signaling pathway (GO:0023058)2.44837810
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44010273
88protein targeting (GO:0006605)2.43258711
89detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43082978
90positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.43024673
91positive regulation of natural killer cell mediated immunity (GO:0002717)2.42180648
92kynurenine metabolic process (GO:0070189)2.40255470
93regulation of cholesterol biosynthetic process (GO:0045540)2.37218819
94RNA phosphodiester bond hydrolysis (GO:0090501)2.35430123
95histone H3 deacetylation (GO:0070932)2.33053904
96prostanoid biosynthetic process (GO:0046457)2.32044714
97prostaglandin biosynthetic process (GO:0001516)2.32044714
98brown fat cell differentiation (GO:0050873)2.30146005
99ribosomal small subunit biogenesis (GO:0042274)11.6299507
100ncRNA 3-end processing (GO:0043628)10.0584180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.94417181
2EZH2_22144423_ChIP-Seq_EOC_Human6.23129536
3VDR_22108803_ChIP-Seq_LS180_Human3.33427154
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.07992539
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.43770572
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.27327025
7ZNF274_21170338_ChIP-Seq_K562_Hela2.22252416
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.13686822
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09932403
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02281925
11POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.96160562
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92946456
13IRF1_19129219_ChIP-ChIP_H3396_Human1.91895069
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91719351
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89373990
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82832428
17RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75010511
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70053106
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69006296
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66334792
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.66112639
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.63393361
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62723057
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.58509352
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56934572
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51471052
27ERA_21632823_ChIP-Seq_H3396_Human1.50497371
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45898976
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43304494
30HTT_18923047_ChIP-ChIP_STHdh_Human1.42420301
31NANOG_20526341_ChIP-Seq_ESCs_Human1.41831511
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40657802
33EWS_26573619_Chip-Seq_HEK293_Human1.40503442
34REST_21632747_ChIP-Seq_MESCs_Mouse1.39014529
35TP53_22573176_ChIP-Seq_HFKS_Human1.38945006
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38632501
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.38627249
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38244786
39NCOR_22424771_ChIP-Seq_293T_Human1.37575099
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36113216
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36113216
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34079896
43TAF2_19829295_ChIP-Seq_ESCs_Human1.29447200
44CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26954632
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25063561
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24953863
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24726376
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24413840
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23812672
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22901513
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22738161
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21583690
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.20977884
54EGR1_19032775_ChIP-ChIP_M12_Human1.20568350
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20095043
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17913476
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.17913476
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16528953
59VDR_23849224_ChIP-Seq_CD4+_Human1.11861738
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11709321
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11612926
62RNF2_27304074_Chip-Seq_NSC_Mouse1.10118675
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09418236
64P53_21459846_ChIP-Seq_SAOS-2_Human1.08738227
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.08596662
66FUS_26573619_Chip-Seq_HEK293_Human1.07746602
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05406662
68MYC_19829295_ChIP-Seq_ESCs_Human1.01740256
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00401870
70CTCF_20526341_ChIP-Seq_ESCs_Human1.00363529
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99892074
72GATA3_21878914_ChIP-Seq_MCF-7_Human0.99741921
73BCL6_27268052_Chip-Seq_Bcells_Human0.99535308
74MYC_18555785_ChIP-Seq_MESCs_Mouse0.99441155
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98830140
76P300_19829295_ChIP-Seq_ESCs_Human0.98765560
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.98761074
78BCAT_22108803_ChIP-Seq_LS180_Human0.97927020
79RAC3_21632823_ChIP-Seq_H3396_Human0.97897031
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97273862
81E2F1_20622854_ChIP-Seq_HELA_Human0.96692636
82HOXB7_26014856_ChIP-Seq_BT474_Human0.96558227
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95003654
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.94688558
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94073071
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93278888
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.92729310
88CTCF_27219007_Chip-Seq_Bcells_Human0.91815611
89P300_27268052_Chip-Seq_Bcells_Human0.91663871
90MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91541991
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89725639
92MYC_18940864_ChIP-ChIP_HL60_Human0.88825743
93PHF8_20622854_ChIP-Seq_HELA_Human0.87879034
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87584827
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87230253
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.86832039
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85338119
98SOX2_21211035_ChIP-Seq_LN229_Human0.85029003
99OCT4_19829295_ChIP-Seq_ESCs_Human0.84987789
100GATA3_21867929_ChIP-Seq_TH1_Mouse0.84950378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis5.48199862
2MP0001873_stomach_inflammation4.26832292
3MP0006082_CNS_inflammation3.64745643
4MP0003121_genomic_imprinting3.44601305
5MP0006292_abnormal_olfactory_placode3.28915731
6MP0009379_abnormal_foot_pigmentation3.08062553
7MP0003879_abnormal_hair_cell2.90211282
8MP0002163_abnormal_gland_morphology2.62077426
9MP0003646_muscle_fatigue2.52384789
10MP0008877_abnormal_DNA_methylation2.48136988
11MP0001727_abnormal_embryo_implantation2.27750184
12MP0002837_dystrophic_cardiac_calcinosis2.01393583
13MP0002876_abnormal_thyroid_physiology1.95210270
14MP0003787_abnormal_imprinting1.87667313
15MP0009780_abnormal_chondrocyte_physiolo1.87126863
16MP0003195_calcinosis1.85255834
17MP0005379_endocrine/exocrine_gland_phen1.82896135
18MP0001968_abnormal_touch/_nociception1.80051073
19MP0001986_abnormal_taste_sensitivity1.76550325
20MP0002102_abnormal_ear_morphology1.69581218
21MP0005551_abnormal_eye_electrophysiolog1.62877291
22MP0002933_joint_inflammation1.59971151
23MP0003122_maternal_imprinting1.59014924
24MP0005671_abnormal_response_to1.56717503
25MP0001663_abnormal_digestive_system1.55784270
26MP0004142_abnormal_muscle_tone1.53498097
27MP0000566_synostosis1.50197135
28MP0006072_abnormal_retinal_apoptosis1.44866057
29MP0004133_heterotaxia1.44143490
30MP0008789_abnormal_olfactory_epithelium1.40727558
31MP0005646_abnormal_pituitary_gland1.40461933
32MP0005174_abnormal_tail_pigmentation1.38579033
33MP0000631_abnormal_neuroendocrine_gland1.37456892
34MP0002272_abnormal_nervous_system1.35630206
35MP0001905_abnormal_dopamine_level1.34982083
36MP0001348_abnormal_lacrimal_gland1.34981772
37MP0002736_abnormal_nociception_after1.34497194
38MP0004145_abnormal_muscle_electrophysio1.32451740
39MP0003123_paternal_imprinting1.25726977
40MP0004742_abnormal_vestibular_system1.21425504
41MP0008875_abnormal_xenobiotic_pharmacok1.16039493
42MP0002938_white_spotting1.15731873
43MP0008872_abnormal_physiological_respon1.12984774
44MP0003693_abnormal_embryo_hatching1.12644230
45MP0005381_digestive/alimentary_phenotyp1.12598936
46MP0009745_abnormal_behavioral_response1.12342010
47MP0001970_abnormal_pain_threshold1.10964559
48MP0002277_abnormal_respiratory_mucosa1.09506364
49MP0003011_delayed_dark_adaptation1.09488484
50MP0002735_abnormal_chemical_nociception1.09460015
51MP0009333_abnormal_splenocyte_physiolog1.05954476
52MP0002572_abnormal_emotion/affect_behav1.02039535
53MP0003136_yellow_coat_color1.01895960
54MP0002734_abnormal_mechanical_nocicepti1.01064467
55MP0002733_abnormal_thermal_nociception1.00321851
56MP0005075_abnormal_melanosome_morpholog0.98295317
57MP0003880_abnormal_central_pattern0.96412180
58MP0005377_hearing/vestibular/ear_phenot0.95814195
59MP0003878_abnormal_ear_physiology0.95814195
60MP0003938_abnormal_ear_development0.95062604
61MP0005195_abnormal_posterior_eye0.94254998
62MP0000026_abnormal_inner_ear0.93028619
63MP0005083_abnormal_biliary_tract0.89209911
64MP0005410_abnormal_fertilization0.88835771
65MP0002928_abnormal_bile_duct0.88272465
66MP0004885_abnormal_endolymph0.86668907
67MP0002752_abnormal_somatic_nervous0.86471004
68MP0009785_altered_susceptibility_to0.86196790
69MP0003635_abnormal_synaptic_transmissio0.86150790
70MP0004043_abnormal_pH_regulation0.86069705
71MP0000049_abnormal_middle_ear0.85513643
72MP0002822_catalepsy0.85468904
73MP0001440_abnormal_grooming_behavior0.84678862
74MP0002095_abnormal_skin_pigmentation0.84437526
75MP0002064_seizures0.82070145
76MP0002638_abnormal_pupillary_reflex0.81890706
77MP0005394_taste/olfaction_phenotype0.81028445
78MP0005499_abnormal_olfactory_system0.81028445
79MP0000372_irregular_coat_pigmentation0.79971624
80MP0001529_abnormal_vocalization0.79363039
81MP0001485_abnormal_pinna_reflex0.76517839
82MP0002063_abnormal_learning/memory/cond0.75949353
83MP0002210_abnormal_sex_determination0.74695217
84MP0005084_abnormal_gallbladder_morpholo0.73910912
85MP0005389_reproductive_system_phenotype0.73829728
86MP0003937_abnormal_limbs/digits/tail_de0.72034525
87MP0002160_abnormal_reproductive_system0.71480468
88MP0005085_abnormal_gallbladder_physiolo0.71080236
89MP0001800_abnormal_humoral_immune0.70668637
90MP0003183_abnormal_peptide_metabolism0.70665901
91MP0004130_abnormal_muscle_cell0.70277961
92MP0001293_anophthalmia0.68953847
93MP0005310_abnormal_salivary_gland0.68380158
94MP0003283_abnormal_digestive_organ0.67885477
95MP0000778_abnormal_nervous_system0.67868063
96MP0005253_abnormal_eye_physiology0.66737721
97MP0006276_abnormal_autonomic_nervous0.66417859
98MP0001984_abnormal_olfaction0.65668994
99MP0002653_abnormal_ependyma_morphology0.65213413
100MP0002184_abnormal_innervation0.64474644

Predicted human phenotypes

RankGene SetZ-score
1Striae distensae (HP:0001065)6.32560056
2Constricted visual fields (HP:0001133)6.20799372
3Metaphyseal cupping (HP:0003021)6.20282262
4Volvulus (HP:0002580)6.06452642
5Abnormality of macular pigmentation (HP:0008002)5.93604934
6Round ear (HP:0100830)5.47218296
7Cupped ribs (HP:0000887)5.09131639
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.65024949
9Attenuation of retinal blood vessels (HP:0007843)4.45402235
10Cone-rod dystrophy (HP:0000548)4.43189026
11Septo-optic dysplasia (HP:0100842)4.09938290
12Toxemia of pregnancy (HP:0100603)3.97442272
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.83757751
14Reticulocytopenia (HP:0001896)3.76893690
15Optic disc pallor (HP:0000543)3.34791315
16Oligodontia (HP:0000677)3.15940278
17Abnormality of the labia minora (HP:0012880)3.02897922
18Abnormality of cells of the erythroid lineage (HP:0012130)3.01385153
19Small hand (HP:0200055)2.97498813
20Decreased muscle mass (HP:0003199)2.91481821
21Acute necrotizing encephalopathy (HP:0006965)2.90474917
22Hyperthyroidism (HP:0000836)2.89391085
23Tibial bowing (HP:0002982)2.86226849
24Abnormal rod and cone electroretinograms (HP:0008323)2.84955072
25Broad nasal tip (HP:0000455)2.75003427
26Molar tooth sign on MRI (HP:0002419)2.73202066
27Abnormality of midbrain morphology (HP:0002418)2.73202066
28Hyperglycinemia (HP:0002154)2.70033240
29Lack of skin elasticity (HP:0100679)2.63054403
30Asplenia (HP:0001746)2.58981328
31Aplasia/Hypoplasia of the spleen (HP:0010451)2.56771162
32Absent septum pellucidum (HP:0001331)2.56098957
33Large earlobe (HP:0009748)2.54266857
34Type II lissencephaly (HP:0007260)2.53241955
35Macrocytic anemia (HP:0001972)2.52984915
36Congenital, generalized hypertrichosis (HP:0004540)2.50612244
37Abnormal number of erythroid precursors (HP:0012131)2.48664594
38Concave nail (HP:0001598)2.47375291
393-Methylglutaconic aciduria (HP:0003535)2.45999437
40Progressive macrocephaly (HP:0004481)2.42410809
41Acute encephalopathy (HP:0006846)2.40513143
42Abnormal mitochondria in muscle tissue (HP:0008316)2.38584701
43Brushfield spots (HP:0001088)2.37644285
44Aplastic anemia (HP:0001915)2.37034880
45Mitochondrial inheritance (HP:0001427)2.36790921
46Congenital stationary night blindness (HP:0007642)2.30308776
47Ovoid vertebral bodies (HP:0003300)2.28003655
48Pallor (HP:0000980)2.23172832
49Hypoplastic ischia (HP:0003175)2.20501138
50Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18225577
51Femoral bowing (HP:0002980)2.17814680
52Hepatocellular necrosis (HP:0001404)2.16626035
53Pancreatic fibrosis (HP:0100732)2.13502016
54Increased CSF lactate (HP:0002490)2.12519673
55True hermaphroditism (HP:0010459)2.08925570
56Cerebral edema (HP:0002181)2.07288106
57Pancreatic cysts (HP:0001737)2.00404603
58Severe visual impairment (HP:0001141)1.99126582
59Absent thumb (HP:0009777)1.93357232
60Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92196538
61Abnormality of the septum pellucidum (HP:0007375)1.89991079
62Horseshoe kidney (HP:0000085)1.89888825
63Cerebellar dysplasia (HP:0007033)1.89124148
64Rib fusion (HP:0000902)1.86322051
65Abnormality of the renal collecting system (HP:0004742)1.85386911
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84509656
67Hypoplastic ilia (HP:0000946)1.84013865
68Hepatic necrosis (HP:0002605)1.82075122
69Abolished electroretinogram (ERG) (HP:0000550)1.81773814
70Retinitis pigmentosa (HP:0000510)1.80036193
71Prominent supraorbital ridges (HP:0000336)1.78599897
72Methylmalonic aciduria (HP:0012120)1.78344087
73Methylmalonic acidemia (HP:0002912)1.77876296
74Postnatal growth retardation (HP:0008897)1.77648208
75Sclerocornea (HP:0000647)1.76228425
76Decreased testicular size (HP:0008734)1.75492544
77Pendular nystagmus (HP:0012043)1.72743838
78Medial flaring of the eyebrow (HP:0010747)1.71298651
79Multicystic kidney dysplasia (HP:0000003)1.68588200
80Renal Fanconi syndrome (HP:0001994)1.68104389
81Melanoma (HP:0002861)1.68039691
82Vitreoretinal degeneration (HP:0000655)1.66941793
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66464242
84Duplicated collecting system (HP:0000081)1.65817796
85Recurrent otitis media (HP:0000403)1.65182744
86Abnormality of the ischium (HP:0003174)1.65121496
87Widely spaced teeth (HP:0000687)1.64353218
88Limited elbow extension (HP:0001377)1.64294971
89Coxa vara (HP:0002812)1.64146915
90Prenatal maternal abnormality (HP:0002686)1.63825580
91Aplasia/Hypoplasia of the nipples (HP:0006709)1.63139539
92Female pseudohermaphroditism (HP:0010458)1.62954712
93Photophobia (HP:0000613)1.62804289
94Increased hepatocellular lipid droplets (HP:0006565)1.59847447
95Aplasia/Hypoplasia of the patella (HP:0006498)1.59772393
96Cystic liver disease (HP:0006706)1.59171133
97Emotional lability (HP:0000712)1.58505283
98Patellar aplasia (HP:0006443)1.57848188
99Furrowed tongue (HP:0000221)1.56847253
100Pancytopenia (HP:0001876)1.56114846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT6.36362910
2FES4.12846589
3BCKDK3.15480265
4ZAK3.07635768
5TYRO32.99985530
6TEC2.97168131
7WNK42.89433645
8ADRBK22.59903156
9CDK192.48418322
10TLK12.47268078
11MAP4K12.09468584
12WNK32.01420638
13TESK21.98171000
14GRK11.71688115
15LRRK21.71020299
16VRK11.65565954
17TXK1.60998658
18SYK1.59568470
19TESK11.58574936
20TNK21.53237367
21IKBKB1.48281195
22DYRK21.45486987
23PINK11.44092745
24PLK41.36941591
25FRK1.36524243
26STK161.35339932
27PAK31.21669709
28NEK21.20277107
29SIK21.18185903
30CSK1.11477562
31PASK1.10041558
32KDR1.09439085
33NUAK11.01756439
34PRKCQ1.00718653
35CDK31.00605903
36STK391.00174195
37MINK10.98685087
38RPS6KA40.89020539
39ADRBK10.89003288
40MAPK150.87901810
41VRK20.82689493
42OXSR10.81681988
43MAP2K70.78367484
44RPS6KB20.74212437
45CDC70.73269723
46PRKACA0.71659656
47ABL20.69563664
48INSRR0.68915563
49TIE10.68866713
50FGR0.68543618
51TAOK30.67676076
52PRKCG0.67520802
53NTRK20.65100728
54INSR0.62085061
55IRAK40.61777944
56LYN0.60978801
57CSF1R0.59743237
58LCK0.59583037
59CSNK1A10.56420656
60BTK0.54461735
61RPS6KA50.52467706
62CSNK1D0.52310321
63CAMK10.51914394
64PLK30.51897444
65LIMK10.51807843
66RET0.50542092
67OBSCN0.50108061
68MAPK130.49961043
69PIK3CA0.49850095
70PRKCA0.46985998
71MAP3K110.46745569
72TAOK10.45807051
73CAMK2A0.45788898
74EPHB20.45111795
75IKBKE0.43712016
76SRC0.43003010
77CASK0.42011997
78NME20.41295664
79ITK0.39936192
80PKN10.39100003
81PLK10.38618597
82MARK10.38589527
83GRK50.37263631
84AURKA0.36679497
85ABL10.36142076
86CSNK1E0.34960689
87CDK80.34715815
88TSSK60.33039167
89PIM10.32669890
90PRKCD0.32598201
91CSNK2A20.32214751
92PRKDC0.30476964
93WNK10.30412671
94STK110.30329612
95MATK0.29543065
96CHEK20.29367707
97PRKCB0.28872525
98MAPKAPK50.28843055
99PRKCZ0.27433847
100NME10.27064138

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.44310659
2Oxidative phosphorylation_Homo sapiens_hsa001904.54668094
3Parkinsons disease_Homo sapiens_hsa050123.30483946
4Phototransduction_Homo sapiens_hsa047442.78228027
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74362711
6Alzheimers disease_Homo sapiens_hsa050102.36237342
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27558301
8Huntingtons disease_Homo sapiens_hsa050162.16993963
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06612817
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.98235604
11Tryptophan metabolism_Homo sapiens_hsa003801.96367920
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86423481
13Proteasome_Homo sapiens_hsa030501.83154648
14Mismatch repair_Homo sapiens_hsa034301.83148656
15Cardiac muscle contraction_Homo sapiens_hsa042601.76571222
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70996332
17Nitrogen metabolism_Homo sapiens_hsa009101.70926182
18Nicotine addiction_Homo sapiens_hsa050331.62813610
19One carbon pool by folate_Homo sapiens_hsa006701.61825109
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61806216
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49385901
22Sulfur relay system_Homo sapiens_hsa041221.47679315
23Graft-versus-host disease_Homo sapiens_hsa053321.36898463
24Linoleic acid metabolism_Homo sapiens_hsa005911.34254513
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30201163
26Olfactory transduction_Homo sapiens_hsa047401.26992531
27Primary immunodeficiency_Homo sapiens_hsa053401.25690190
28Arachidonic acid metabolism_Homo sapiens_hsa005901.19789410
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19276933
30Histidine metabolism_Homo sapiens_hsa003401.13846474
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13119998
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.10290222
33DNA replication_Homo sapiens_hsa030301.09311151
34Autoimmune thyroid disease_Homo sapiens_hsa053201.08567720
35Homologous recombination_Homo sapiens_hsa034401.03982180
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01500250
37Peroxisome_Homo sapiens_hsa041461.00837400
38Allograft rejection_Homo sapiens_hsa053301.00704472
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96211914
40Type I diabetes mellitus_Homo sapiens_hsa049400.91390357
41Pyruvate metabolism_Homo sapiens_hsa006200.90548302
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87466557
43Glycerolipid metabolism_Homo sapiens_hsa005610.87414827
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86388008
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85677260
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85152536
47Arginine and proline metabolism_Homo sapiens_hsa003300.82610127
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.82447020
49Nucleotide excision repair_Homo sapiens_hsa034200.82213834
50RNA degradation_Homo sapiens_hsa030180.79212529
51Protein export_Homo sapiens_hsa030600.72103934
52Asthma_Homo sapiens_hsa053100.71663073
53beta-Alanine metabolism_Homo sapiens_hsa004100.69704535
54Morphine addiction_Homo sapiens_hsa050320.68651108
55Fanconi anemia pathway_Homo sapiens_hsa034600.68625572
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68561380
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68486717
58RNA polymerase_Homo sapiens_hsa030200.67831919
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67599964
60Taste transduction_Homo sapiens_hsa047420.67517429
61Pyrimidine metabolism_Homo sapiens_hsa002400.65684918
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.65597772
63Purine metabolism_Homo sapiens_hsa002300.65407268
64Alcoholism_Homo sapiens_hsa050340.64016353
65Metabolic pathways_Homo sapiens_hsa011000.63137214
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61575244
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60118350
68Tyrosine metabolism_Homo sapiens_hsa003500.59564377
69Systemic lupus erythematosus_Homo sapiens_hsa053220.55531736
70Steroid biosynthesis_Homo sapiens_hsa001000.54947405
71Propanoate metabolism_Homo sapiens_hsa006400.53561593
72Rheumatoid arthritis_Homo sapiens_hsa053230.51920621
73Antigen processing and presentation_Homo sapiens_hsa046120.51295236
74Butanoate metabolism_Homo sapiens_hsa006500.51098050
75Serotonergic synapse_Homo sapiens_hsa047260.49798904
76Fat digestion and absorption_Homo sapiens_hsa049750.48719103
77Fatty acid degradation_Homo sapiens_hsa000710.47583156
78Caffeine metabolism_Homo sapiens_hsa002320.45669192
79Glutamatergic synapse_Homo sapiens_hsa047240.45570292
80Retinol metabolism_Homo sapiens_hsa008300.45097545
81Hematopoietic cell lineage_Homo sapiens_hsa046400.44919409
82Basal cell carcinoma_Homo sapiens_hsa052170.44618540
83Chemical carcinogenesis_Homo sapiens_hsa052040.42817759
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.42147207
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40783664
86Synaptic vesicle cycle_Homo sapiens_hsa047210.39566866
87RNA transport_Homo sapiens_hsa030130.37993546
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37675880
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31681168
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30371198
91Sulfur metabolism_Homo sapiens_hsa009200.28291981
92Ovarian steroidogenesis_Homo sapiens_hsa049130.28186931
93Ether lipid metabolism_Homo sapiens_hsa005650.26372915
94Collecting duct acid secretion_Homo sapiens_hsa049660.23555426
95Malaria_Homo sapiens_hsa051440.22793177
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.22576802
97Calcium signaling pathway_Homo sapiens_hsa040200.22082770
98GABAergic synapse_Homo sapiens_hsa047270.22046922
99Melanoma_Homo sapiens_hsa052180.21649864
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21386764

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