RPSAP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.75785771
2maturation of SSU-rRNA (GO:0030490)6.97582273
3viral transcription (GO:0019083)6.19308872
4ribosomal small subunit biogenesis (GO:0042274)6.17609525
5establishment of protein localization to mitochondrial membrane (GO:0090151)6.06853412
6translational termination (GO:0006415)6.00020170
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.94297536
8ATP synthesis coupled proton transport (GO:0015986)5.94297536
9chaperone-mediated protein transport (GO:0072321)5.53161494
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.45378071
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.25982946
12cotranslational protein targeting to membrane (GO:0006613)5.19776850
13protein targeting to ER (GO:0045047)5.12682512
14translational elongation (GO:0006414)5.12251006
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.88427923
16viral life cycle (GO:0019058)4.80476159
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.79497635
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.79497635
19NADH dehydrogenase complex assembly (GO:0010257)4.79497635
20protein localization to endoplasmic reticulum (GO:0070972)4.79484354
21protein complex biogenesis (GO:0070271)4.73638484
22cellular protein complex disassembly (GO:0043624)4.53571160
23ribosomal large subunit biogenesis (GO:0042273)4.40395091
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.33075269
25mitochondrial respiratory chain complex assembly (GO:0033108)4.31750739
26translational initiation (GO:0006413)4.20328051
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.15830185
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.15830185
29respiratory electron transport chain (GO:0022904)4.15654612
30electron transport chain (GO:0022900)4.13388134
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07592251
32protein neddylation (GO:0045116)3.98320859
33DNA deamination (GO:0045006)3.90187042
34replication fork processing (GO:0031297)3.88105667
35cellular component biogenesis (GO:0044085)3.83782535
36protein complex disassembly (GO:0043241)3.83036131
37oxygen transport (GO:0015671)3.82856741
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73425317
39translation (GO:0006412)3.71988701
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70506979
41macromolecular complex disassembly (GO:0032984)3.66050806
42ribonucleoprotein complex biogenesis (GO:0022613)3.58234630
43water-soluble vitamin biosynthetic process (GO:0042364)3.47997212
44respiratory chain complex IV assembly (GO:0008535)3.47769368
45chromatin remodeling at centromere (GO:0031055)3.47621919
46proteasome assembly (GO:0043248)3.45063647
47peptidyl-threonine dephosphorylation (GO:0035970)3.42358818
48ncRNA 3-end processing (GO:0043628)3.40128531
49protein targeting to membrane (GO:0006612)3.37054540
50protein-cofactor linkage (GO:0018065)3.34107284
51rRNA modification (GO:0000154)3.33662196
52nuclear-transcribed mRNA catabolic process (GO:0000956)3.30829438
53ATP biosynthetic process (GO:0006754)3.29841265
54regulation of oxidative phosphorylation (GO:0002082)3.28396270
55gas transport (GO:0015669)3.26327685
56intracellular protein transmembrane import (GO:0044743)3.24455337
57hydrogen ion transmembrane transport (GO:1902600)3.22733619
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.18408370
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17681581
60mRNA catabolic process (GO:0006402)3.14100433
61behavioral response to nicotine (GO:0035095)3.13778774
62maturation of 5.8S rRNA (GO:0000460)3.12926201
63rRNA processing (GO:0006364)3.06227775
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05910642
65protein targeting to mitochondrion (GO:0006626)3.03695896
66cytochrome complex assembly (GO:0017004)3.03181550
67rRNA metabolic process (GO:0016072)3.01092733
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00249073
69rRNA catabolic process (GO:0016075)2.98270628
70CENP-A containing nucleosome assembly (GO:0034080)2.95707154
71cellular ketone body metabolic process (GO:0046950)2.95678106
72RNA catabolic process (GO:0006401)2.93467372
73protein peptidyl-prolyl isomerization (GO:0000413)2.92407699
74establishment of protein localization to mitochondrion (GO:0072655)2.90421167
75protein localization to mitochondrion (GO:0070585)2.88333933
76negative regulation of telomere maintenance (GO:0032205)2.87865781
77iron-sulfur cluster assembly (GO:0016226)2.87309762
78metallo-sulfur cluster assembly (GO:0031163)2.87309762
79regulation of cellular respiration (GO:0043457)2.85249321
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84786164
81proton transport (GO:0015992)2.84529736
82GTP biosynthetic process (GO:0006183)2.79175915
83hydrogen transport (GO:0006818)2.77921244
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77207608
85regulation of cellular amino acid metabolic process (GO:0006521)2.76395706
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75476273
87DNA damage response, detection of DNA damage (GO:0042769)2.68190058
88rRNA methylation (GO:0031167)2.67938463
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67641166
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67188932
91negative regulation of ligase activity (GO:0051352)2.67188932
92tRNA processing (GO:0008033)2.67018954
93cardiovascular system development (GO:0072358)2.64298060
94RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.62900540
95ketone body metabolic process (GO:1902224)2.61710580
96DNA strand renaturation (GO:0000733)2.61344676
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58422728
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57563564
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.57276374
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52993776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.70133884
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69624267
3EZH2_22144423_ChIP-Seq_EOC_Human4.51020003
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.50018645
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.64015754
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33020420
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27266358
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.18276833
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03647960
10VDR_22108803_ChIP-Seq_LS180_Human2.77277554
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.62383004
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48229644
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40156506
14ZNF274_21170338_ChIP-Seq_K562_Hela2.37670783
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26181555
16VDR_23849224_ChIP-Seq_CD4+_Human2.21825177
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09675338
18ELK1_19687146_ChIP-ChIP_HELA_Human1.98055587
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96040762
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94629347
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88243243
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87797906
23FOXP3_21729870_ChIP-Seq_TREG_Human1.83855785
24GABP_19822575_ChIP-Seq_HepG2_Human1.82513121
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.80241201
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79749027
27XRN2_22483619_ChIP-Seq_HELA_Human1.79401345
28MYC_18940864_ChIP-ChIP_HL60_Human1.78435411
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73728200
30TTF2_22483619_ChIP-Seq_HELA_Human1.70130543
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67540416
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.64323088
33IRF1_19129219_ChIP-ChIP_H3396_Human1.58673002
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56410520
35TP53_22573176_ChIP-Seq_HFKS_Human1.55767265
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54429338
37EWS_26573619_Chip-Seq_HEK293_Human1.53503625
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47773226
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44332109
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43412573
41IGF1R_20145208_ChIP-Seq_DFB_Human1.38194468
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35545791
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.29438494
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27401145
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27331485
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.26870858
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25115630
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24706711
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23992376
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.21236513
51DCP1A_22483619_ChIP-Seq_HELA_Human1.19283855
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18218054
53E2F7_22180533_ChIP-Seq_HELA_Human1.17369180
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13749446
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12669433
56NCOR_22424771_ChIP-Seq_293T_Human1.11224230
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10544736
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10264552
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09856170
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09216689
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06157713
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06157713
63SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04492454
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00342056
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00000481
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97478534
67GATA1_26923725_Chip-Seq_HPCs_Mouse0.95385236
68TAF2_19829295_ChIP-Seq_ESCs_Human0.95286358
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94580992
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92923838
71GATA3_21878914_ChIP-Seq_MCF-7_Human0.92788019
72FUS_26573619_Chip-Seq_HEK293_Human0.91573112
73AR_21572438_ChIP-Seq_LNCaP_Human0.90198464
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90162477
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90040859
76ELK1_22589737_ChIP-Seq_MCF10A_Human0.89321110
77CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88994322
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88604899
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88093565
80SOX2_19829295_ChIP-Seq_ESCs_Human0.88016065
81NANOG_19829295_ChIP-Seq_ESCs_Human0.88016065
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.87414765
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87414765
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86530125
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.86510801
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85931608
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.84553563
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84543974
89PHF8_20622853_ChIP-Seq_HELA_Human0.83635292
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.83537828
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83246430
92P53_21459846_ChIP-Seq_SAOS-2_Human0.83068557
93RNF2_27304074_Chip-Seq_NSC_Mouse0.82797130
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82715832
95ERA_21632823_ChIP-Seq_H3396_Human0.82528831
96STAT1_20625510_ChIP-Seq_HELA_Human0.82363456
97NANOG_20526341_ChIP-Seq_ESCs_Human0.82024660
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81566741
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81188352
100CIITA_25753668_ChIP-Seq_RAJI_Human0.80489548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.35539086
2MP0006292_abnormal_olfactory_placode3.52910791
3MP0001986_abnormal_taste_sensitivity2.93895366
4MP0002138_abnormal_hepatobiliary_system2.89990881
5MP0005377_hearing/vestibular/ear_phenot2.56068293
6MP0003878_abnormal_ear_physiology2.56068293
7MP0004147_increased_porphyrin_level2.44530004
8MP0005645_abnormal_hypothalamus_physiol2.36176703
9MP0008789_abnormal_olfactory_epithelium2.34593739
10MP0002163_abnormal_gland_morphology2.16968855
11MP0004885_abnormal_endolymph1.99133180
12MP0003693_abnormal_embryo_hatching1.98698608
13MP0005394_taste/olfaction_phenotype1.96037175
14MP0005499_abnormal_olfactory_system1.96037175
15MP0008872_abnormal_physiological_respon1.92473550
16MP0008875_abnormal_xenobiotic_pharmacok1.89424959
17MP0003136_yellow_coat_color1.85002333
18MP0005084_abnormal_gallbladder_morpholo1.81668874
19MP0002638_abnormal_pupillary_reflex1.81182259
20MP0003123_paternal_imprinting1.77515482
21MP0002160_abnormal_reproductive_system1.74449832
22MP0004145_abnormal_muscle_electrophysio1.70998068
23MP0001968_abnormal_touch/_nociception1.69447513
24MP0005646_abnormal_pituitary_gland1.65657526
25MP0005083_abnormal_biliary_tract1.65572443
26MP0002938_white_spotting1.60486713
27MP0003787_abnormal_imprinting1.57643764
28MP0003186_abnormal_redox_activity1.55156809
29MP0002735_abnormal_chemical_nociception1.54366210
30MP0002095_abnormal_skin_pigmentation1.53290907
31MP0008877_abnormal_DNA_methylation1.43529583
32MP0002277_abnormal_respiratory_mucosa1.43077975
33MP0001485_abnormal_pinna_reflex1.39601559
34MP0002736_abnormal_nociception_after1.39458728
35MP0000372_irregular_coat_pigmentation1.39258679
36MP0005551_abnormal_eye_electrophysiolog1.38756124
37MP0001529_abnormal_vocalization1.35582165
38MP0003122_maternal_imprinting1.33365439
39MP0002733_abnormal_thermal_nociception1.32501418
40MP0005379_endocrine/exocrine_gland_phen1.30233967
41MP0001905_abnormal_dopamine_level1.29259482
42MP0004957_abnormal_blastocyst_morpholog1.28353396
43MP0005389_reproductive_system_phenotype1.25981490
44MP0004142_abnormal_muscle_tone1.25005810
45MP0004742_abnormal_vestibular_system1.24632194
46MP0001293_anophthalmia1.24070740
47MP0003646_muscle_fatigue1.23925093
48MP0006276_abnormal_autonomic_nervous1.23339254
49MP0000778_abnormal_nervous_system1.21870459
50MP0001440_abnormal_grooming_behavior1.21205001
51MP0003880_abnormal_central_pattern1.20466679
52MP0002822_catalepsy1.20352282
53MP0002234_abnormal_pharynx_morphology1.19112091
54MP0004043_abnormal_pH_regulation1.17896118
55MP0005423_abnormal_somatic_nervous1.17675897
56MP0006036_abnormal_mitochondrial_physio1.17289886
57MP0002272_abnormal_nervous_system1.17141405
58MP0003806_abnormal_nucleotide_metabolis1.16925117
59MP0002653_abnormal_ependyma_morphology1.16762041
60MP0000015_abnormal_ear_pigmentation1.16101511
61MP0009745_abnormal_behavioral_response1.14946741
62MP0002837_dystrophic_cardiac_calcinosis1.12815346
63MP0005636_abnormal_mineral_homeostasis1.07516004
64MP0003718_maternal_effect1.05574354
65MP0000631_abnormal_neuroendocrine_gland1.05133407
66MP0003121_genomic_imprinting1.02760939
67MP0001324_abnormal_eye_pigmentation1.02437410
68MP0006072_abnormal_retinal_apoptosis1.00561277
69MP0001970_abnormal_pain_threshold0.99746707
70MP0001984_abnormal_olfaction0.99209259
71MP0002557_abnormal_social/conspecific_i0.99099080
72MP0001486_abnormal_startle_reflex0.98415788
73MP0008058_abnormal_DNA_repair0.98273358
74MP0003011_delayed_dark_adaptation0.98049335
75MP0002139_abnormal_hepatobiliary_system0.96644518
76MP0004133_heterotaxia0.95798264
77MP0005085_abnormal_gallbladder_physiolo0.94759430
78MP0003315_abnormal_perineum_morphology0.92270396
79MP0005195_abnormal_posterior_eye0.92001454
80MP0000049_abnormal_middle_ear0.91845020
81MP0002210_abnormal_sex_determination0.90134356
82MP0002752_abnormal_somatic_nervous0.89843827
83MP0009697_abnormal_copulation0.89692702
84MP0002233_abnormal_nose_morphology0.88529352
85MP0002928_abnormal_bile_duct0.88258152
86MP0001764_abnormal_homeostasis0.86313485
87MP0000026_abnormal_inner_ear0.86287635
88MP0003786_premature_aging0.83885667
89MP0002102_abnormal_ear_morphology0.78682992
90MP0009046_muscle_twitch0.77999523
91MP0003111_abnormal_nucleus_morphology0.77395171
92MP0001188_hyperpigmentation0.77090595
93MP0000955_abnormal_spinal_cord0.76869401
94MP0001919_abnormal_reproductive_system0.75909887
95MP0002064_seizures0.74905467
96MP0006054_spinal_hemorrhage0.74497960
97MP0003195_calcinosis0.74396603
98MP0003937_abnormal_limbs/digits/tail_de0.73479314
99MP0003635_abnormal_synaptic_transmissio0.72927971
100MP0001881_abnormal_mammary_gland0.70615199

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.43890253
2Acute necrotizing encephalopathy (HP:0006965)5.41653128
3Abnormal hemoglobin (HP:0011902)5.01637041
4Abnormal mitochondria in muscle tissue (HP:0008316)4.96510434
5Acute encephalopathy (HP:0006846)4.59905711
6Mitochondrial inheritance (HP:0001427)4.44099126
7Progressive macrocephaly (HP:0004481)4.41085224
8Hepatocellular necrosis (HP:0001404)4.22139267
9Pancreatic fibrosis (HP:0100732)4.22101376
10Increased CSF lactate (HP:0002490)4.03935621
11Abnormality of cells of the erythroid lineage (HP:0012130)3.73920382
12True hermaphroditism (HP:0010459)3.71690859
13Hepatic necrosis (HP:0002605)3.71520301
14Pallor (HP:0000980)3.67763119
15Pancreatic cysts (HP:0001737)3.57968187
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.33856059
17Abnormality of midbrain morphology (HP:0002418)3.29032387
18Molar tooth sign on MRI (HP:0002419)3.29032387
19Septo-optic dysplasia (HP:0100842)3.26415343
20Cerebral edema (HP:0002181)3.15144773
21Macrocytic anemia (HP:0001972)3.14144637
22Anencephaly (HP:0002323)3.01528331
23Abnormal number of erythroid precursors (HP:0012131)2.96582380
24Abnormality of DNA repair (HP:0003254)2.86385960
25Increased hepatocellular lipid droplets (HP:0006565)2.81405965
26Nephronophthisis (HP:0000090)2.72001898
27Lipid accumulation in hepatocytes (HP:0006561)2.68668620
28Leukodystrophy (HP:0002415)2.63532761
29Bile duct proliferation (HP:0001408)2.62339511
30Abnormal biliary tract physiology (HP:0012439)2.62339511
31Sclerocornea (HP:0000647)2.60372370
32Cystic liver disease (HP:0006706)2.58857647
33Congenital, generalized hypertrichosis (HP:0004540)2.56221601
34Renal Fanconi syndrome (HP:0001994)2.51497256
35Optic disc pallor (HP:0000543)2.43539501
36Increased serum lactate (HP:0002151)2.42343105
37Tubular atrophy (HP:0000092)2.41637568
38Congenital hepatic fibrosis (HP:0002612)2.41177438
39Abnormality of the renal cortex (HP:0011035)2.41127095
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37325179
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37325179
42Abnormality of the anterior horn cell (HP:0006802)2.35860106
43Degeneration of anterior horn cells (HP:0002398)2.35860106
44Medial flaring of the eyebrow (HP:0010747)2.35701849
45Pendular nystagmus (HP:0012043)2.30130518
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29994804
47Abnormality of alanine metabolism (HP:0010916)2.29994804
48Hyperalaninemia (HP:0003348)2.29994804
49Respiratory failure (HP:0002878)2.28349895
50Lactic acidosis (HP:0003128)2.27981849
51Postaxial foot polydactyly (HP:0001830)2.27782455
52Abnormality of the renal medulla (HP:0100957)2.27727700
53Male pseudohermaphroditism (HP:0000037)2.22790653
54Increased intramyocellular lipid droplets (HP:0012240)2.17330895
55Congenital stationary night blindness (HP:0007642)2.13906245
56Exercise intolerance (HP:0003546)2.13718042
57Adrenal hypoplasia (HP:0000835)2.13212301
58Abnormal rod and cone electroretinograms (HP:0008323)2.12553794
59Increased serum pyruvate (HP:0003542)2.11570708
60Abnormal drinking behavior (HP:0030082)2.08421839
61Polydipsia (HP:0001959)2.08421839
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07829960
63Absent septum pellucidum (HP:0001331)2.07215772
64Colon cancer (HP:0003003)2.06875473
65Abnormal number of incisors (HP:0011064)2.05453513
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99242871
67Exertional dyspnea (HP:0002875)1.98470500
68Myokymia (HP:0002411)1.97414846
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.97029209
70Absent thumb (HP:0009777)1.94108758
71Chronic hepatic failure (HP:0100626)1.93351602
72Abnormality of the labia minora (HP:0012880)1.91940685
73Holoprosencephaly (HP:0001360)1.91514030
74Rib fusion (HP:0000902)1.88229113
75Abnormality of reticulocytes (HP:0004312)1.88076023
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.87491729
77Optic nerve hypoplasia (HP:0000609)1.87289030
78Lethargy (HP:0001254)1.87233129
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84995615
80Increased muscle lipid content (HP:0009058)1.84732016
81Maternal diabetes (HP:0009800)1.84299555
82Hypoplasia of the uterus (HP:0000013)1.83859948
83Hyperglycinemia (HP:0002154)1.83621491
84Abnormality of renal resorption (HP:0011038)1.82925653
85CNS demyelination (HP:0007305)1.80431575
86Renal cortical cysts (HP:0000803)1.79341680
87Respiratory difficulties (HP:0002880)1.78386014
88X-linked dominant inheritance (HP:0001423)1.78334895
89Neonatal respiratory distress (HP:0002643)1.77403914
90Opisthotonus (HP:0002179)1.74793483
91Asplenia (HP:0001746)1.74772461
92Gait imbalance (HP:0002141)1.73022327
93Dry hair (HP:0011359)1.72086620
94Tetany (HP:0001281)1.70482313
95Enlarged kidneys (HP:0000105)1.68534996
96Hyperphosphatemia (HP:0002905)1.67878618
97Depressed nasal ridge (HP:0000457)1.67555607
98Narrow forehead (HP:0000341)1.66066887
99Abnormality of urine glucose concentration (HP:0011016)1.65944120
100Glycosuria (HP:0003076)1.65944120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.41106746
2VRK23.29593277
3TRIM283.14559636
4TAOK32.76657000
5WNK42.65497185
6NUAK12.55788245
7NEK12.50227299
8CDC72.46052244
9TAF12.35405334
10PDK22.23214916
11ZAK2.18723099
12VRK12.08918055
13PLK42.08878315
14PNCK1.99174083
15ADRBK21.82583046
16DYRK21.80956643
17TLK11.78638934
18GRK11.71621711
19MAP3K41.70808419
20MUSK1.65522869
21STK391.60761693
22PLK31.56308587
23NME11.54500946
24STK161.52236398
25EIF2AK11.50868133
26PLK21.50646944
27PHKG11.43031176
28PHKG21.43031176
29TSSK61.39374838
30PINK11.36696927
31MST41.24792982
32WEE11.21686342
33DYRK31.16047802
34ABL21.11951676
35WNK31.11407250
36BCKDK1.09954673
37STK31.07269050
38MAP2K71.06189411
39CDK191.05482899
40LRRK21.04963037
41OXSR11.04261005
42NME20.99592392
43CASK0.93330885
44PLK10.87904539
45CSNK1G20.85443192
46STK38L0.84319658
47BUB10.83181375
48ATR0.83062108
49EPHA40.81178880
50PRKCQ0.79775088
51PRKCG0.79502976
52TXK0.76550732
53PRKCI0.76046456
54PASK0.75657450
55CSNK2A20.73365403
56CHEK20.72699078
57CSNK1G30.68496685
58TTK0.67855171
59PBK0.65716577
60INSRR0.65190649
61AURKB0.64189266
62BRSK20.63506142
63NEK20.63459143
64ADRBK10.63143516
65MINK10.62878928
66BRSK10.61232971
67CSNK2A10.61199736
68MAPK150.60497488
69EIF2AK30.58627367
70TNIK0.57936569
71PRKACA0.57256130
72AURKA0.56399451
73STK240.56274748
74BMPR20.54744601
75ERBB20.54595213
76DMPK0.53978095
77BCR0.53447080
78IKBKB0.53352628
79CSNK1A1L0.51234284
80CDK140.50836427
81DAPK30.49363759
82MKNK20.49226610
83MAPKAPK50.47968458
84DYRK1A0.47325532
85NTRK30.46663703
86CSNK1E0.46242421
87DAPK10.46132557
88PTK2B0.45793067
89CSNK1A10.44078213
90RPS6KA50.43748701
91CDK11A0.43710102
92ATM0.43176689
93TIE10.41345180
94MARK30.40814850
95CDK180.40680493
96MAP3K80.40427885
97CDK150.40027893
98PRKDC0.38723526
99EPHB20.38533621
100TYRO30.38476755

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.17240946
2Oxidative phosphorylation_Homo sapiens_hsa001904.22230093
3Parkinsons disease_Homo sapiens_hsa050123.60061529
4Proteasome_Homo sapiens_hsa030503.52711779
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.67877975
6Protein export_Homo sapiens_hsa030602.64832313
7Huntingtons disease_Homo sapiens_hsa050162.54429595
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35758629
9Alzheimers disease_Homo sapiens_hsa050102.33621281
10One carbon pool by folate_Homo sapiens_hsa006702.17370667
11Cardiac muscle contraction_Homo sapiens_hsa042602.08663726
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03305189
13RNA degradation_Homo sapiens_hsa030181.92401519
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85194069
15Mismatch repair_Homo sapiens_hsa034301.82188715
16DNA replication_Homo sapiens_hsa030301.80641293
17Steroid biosynthesis_Homo sapiens_hsa001001.80049921
18RNA polymerase_Homo sapiens_hsa030201.74959348
19Folate biosynthesis_Homo sapiens_hsa007901.70158688
20Homologous recombination_Homo sapiens_hsa034401.65546327
21Nucleotide excision repair_Homo sapiens_hsa034201.57838801
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52650813
23Phototransduction_Homo sapiens_hsa047441.48055321
24Base excision repair_Homo sapiens_hsa034101.43621027
25Fanconi anemia pathway_Homo sapiens_hsa034601.41914015
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36318370
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32029898
28RNA transport_Homo sapiens_hsa030131.26234163
29Sulfur relay system_Homo sapiens_hsa041221.19591952
30Pyruvate metabolism_Homo sapiens_hsa006201.19395413
31Peroxisome_Homo sapiens_hsa041461.17895825
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17566460
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17458659
34Basal transcription factors_Homo sapiens_hsa030221.15092195
35Nitrogen metabolism_Homo sapiens_hsa009101.14947516
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13754434
37Linoleic acid metabolism_Homo sapiens_hsa005911.12659772
38Fat digestion and absorption_Homo sapiens_hsa049751.11104395
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03552669
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03182203
41Asthma_Homo sapiens_hsa053101.02367048
42Spliceosome_Homo sapiens_hsa030401.01681828
43Purine metabolism_Homo sapiens_hsa002301.01632122
44Butanoate metabolism_Homo sapiens_hsa006501.00391498
45Propanoate metabolism_Homo sapiens_hsa006400.99940563
46Sulfur metabolism_Homo sapiens_hsa009200.99619269
47Pyrimidine metabolism_Homo sapiens_hsa002400.97846131
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.95792061
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92526362
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87453548
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.85934616
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83719611
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82684204
54Metabolic pathways_Homo sapiens_hsa011000.81782909
55Vitamin B6 metabolism_Homo sapiens_hsa007500.81184632
56Tryptophan metabolism_Homo sapiens_hsa003800.79917815
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.79401694
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.74937416
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73837701
60Ether lipid metabolism_Homo sapiens_hsa005650.70167698
61Graft-versus-host disease_Homo sapiens_hsa053320.69542881
62Selenocompound metabolism_Homo sapiens_hsa004500.67627717
63Collecting duct acid secretion_Homo sapiens_hsa049660.66745015
64Arginine and proline metabolism_Homo sapiens_hsa003300.65560075
65Nicotine addiction_Homo sapiens_hsa050330.65283645
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63460099
67Chemical carcinogenesis_Homo sapiens_hsa052040.56471586
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54725914
69Fatty acid degradation_Homo sapiens_hsa000710.52677849
70Allograft rejection_Homo sapiens_hsa053300.51665281
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51657637
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51539915
73Type I diabetes mellitus_Homo sapiens_hsa049400.50703148
74Systemic lupus erythematosus_Homo sapiens_hsa053220.48691222
75Olfactory transduction_Homo sapiens_hsa047400.48632856
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48344400
77Glutathione metabolism_Homo sapiens_hsa004800.45965289
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44171063
79Autoimmune thyroid disease_Homo sapiens_hsa053200.44070878
80Fatty acid elongation_Homo sapiens_hsa000620.42952667
81Glycerolipid metabolism_Homo sapiens_hsa005610.41387029
82Arachidonic acid metabolism_Homo sapiens_hsa005900.38875030
83Morphine addiction_Homo sapiens_hsa050320.38451538
84Basal cell carcinoma_Homo sapiens_hsa052170.35598968
85Retinol metabolism_Homo sapiens_hsa008300.33459047
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30054829
87GABAergic synapse_Homo sapiens_hsa047270.28970192
88Carbon metabolism_Homo sapiens_hsa012000.27141306
89Regulation of autophagy_Homo sapiens_hsa041400.26980681
90N-Glycan biosynthesis_Homo sapiens_hsa005100.22507574
91Non-homologous end-joining_Homo sapiens_hsa034500.21910894
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21372443
93Epstein-Barr virus infection_Homo sapiens_hsa051690.21217564
94beta-Alanine metabolism_Homo sapiens_hsa004100.19137839
95Fatty acid metabolism_Homo sapiens_hsa012120.17078758
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.16789526
97Pancreatic secretion_Homo sapiens_hsa049720.14909778
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14624012
99Rheumatoid arthritis_Homo sapiens_hsa053230.13892223
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13186977

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