RPSAP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.21791556
2maturation of SSU-rRNA (GO:0030490)7.14644434
3viral transcription (GO:0019083)6.95162042
4translational termination (GO:0006415)6.68393989
5ribosomal small subunit biogenesis (GO:0042274)6.40967506
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.80346608
7translational elongation (GO:0006414)5.80129976
8cotranslational protein targeting to membrane (GO:0006613)5.74108366
9protein targeting to ER (GO:0045047)5.68982545
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.45913698
11protein localization to endoplasmic reticulum (GO:0070972)5.38923255
12chaperone-mediated protein transport (GO:0072321)5.38676962
13viral life cycle (GO:0019058)5.20661896
14cellular protein complex disassembly (GO:0043624)5.15386397
15behavioral response to nicotine (GO:0035095)4.92439790
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.87781149
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66000641
18ATP synthesis coupled proton transport (GO:0015986)4.66000641
19water-soluble vitamin biosynthetic process (GO:0042364)4.62611080
20translational initiation (GO:0006413)4.51013412
21protein complex disassembly (GO:0043241)4.41719051
22ribosomal large subunit biogenesis (GO:0042273)4.34370520
23protein complex biogenesis (GO:0070271)4.27342611
24macromolecular complex disassembly (GO:0032984)4.19506651
25substrate-independent telencephalic tangential migration (GO:0021826)4.18306819
26substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.18306819
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15422762
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.15422762
29NADH dehydrogenase complex assembly (GO:0010257)4.15422762
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.15361309
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11541863
32translation (GO:0006412)4.05259823
33protein neddylation (GO:0045116)4.04037869
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01331623
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92818198
36regulation of cilium movement (GO:0003352)3.91022644
37GTP biosynthetic process (GO:0006183)3.89918182
38protein targeting to membrane (GO:0006612)3.88717873
39mitochondrial respiratory chain complex assembly (GO:0033108)3.86068967
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80132003
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80132003
42respiratory electron transport chain (GO:0022904)3.64962308
43electron transport chain (GO:0022900)3.64002433
44cellular component biogenesis (GO:0044085)3.57610180
45termination of RNA polymerase III transcription (GO:0006386)3.53943840
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.53943840
47nuclear-transcribed mRNA catabolic process (GO:0000956)3.52640078
48pattern specification involved in kidney development (GO:0061004)3.44978471
49UTP biosynthetic process (GO:0006228)3.36498466
50pyrimidine nucleotide catabolic process (GO:0006244)3.35050160
51nonmotile primary cilium assembly (GO:0035058)3.33472777
52mRNA catabolic process (GO:0006402)3.33456931
53ribonucleoprotein complex biogenesis (GO:0022613)3.33450570
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26476598
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19430815
56DNA deamination (GO:0045006)3.18268108
57base-excision repair, AP site formation (GO:0006285)3.16080206
58CTP metabolic process (GO:0046036)3.15847142
59CTP biosynthetic process (GO:0006241)3.15847142
60ubiquinone biosynthetic process (GO:0006744)3.14937436
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.14586909
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14009803
63pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12545832
64UTP metabolic process (GO:0046051)3.10292834
65cell proliferation in forebrain (GO:0021846)3.06533109
66RNA catabolic process (GO:0006401)3.02526234
67positive regulation of T cell apoptotic process (GO:0070234)3.00456564
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99810020
69purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97382528
70rRNA processing (GO:0006364)2.86865275
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84532074
72rRNA metabolic process (GO:0016072)2.81732173
73pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81381294
74segment specification (GO:0007379)2.79828262
75ubiquinone metabolic process (GO:0006743)2.78986406
76regulation of microtubule-based movement (GO:0060632)2.77719503
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74577610
78guanosine-containing compound biosynthetic process (GO:1901070)2.73470059
79protein deneddylation (GO:0000338)2.73357688
80cullin deneddylation (GO:0010388)2.72911150
81protein targeting to mitochondrion (GO:0006626)2.71717536
82ATP biosynthetic process (GO:0006754)2.71354812
83protein targeting (GO:0006605)2.71224910
84negative regulation of telomere maintenance (GO:0032205)2.68707342
85pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.64972785
86establishment of protein localization to membrane (GO:0090150)2.63772455
87tRNA processing (GO:0008033)2.62742314
88deoxyribonucleotide catabolic process (GO:0009264)2.61558077
89regulation of mitochondrial translation (GO:0070129)2.60884535
90hydrogen ion transmembrane transport (GO:1902600)2.60861687
91establishment of protein localization to mitochondrion (GO:0072655)2.60032427
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59158421
93sequestering of actin monomers (GO:0042989)2.56213956
94ncRNA 3-end processing (GO:0043628)2.56163792
95positive regulation of protein homooligomerization (GO:0032464)2.54209307
96quinone biosynthetic process (GO:1901663)2.54013661
97chromatin remodeling at centromere (GO:0031055)2.49461903
98epithelial cilium movement (GO:0003351)2.49373561
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48091591
100respiratory chain complex IV assembly (GO:0008535)2.48002176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24258479
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.98078547
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87106947
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.55084644
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30008242
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.21037888
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18665473
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.04413029
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71973876
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66476206
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.63280738
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55021213
13VDR_22108803_ChIP-Seq_LS180_Human2.45455484
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32894484
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28692529
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24385674
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17864258
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.13420876
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07314182
20VDR_23849224_ChIP-Seq_CD4+_Human2.04528128
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04417510
22MYC_18940864_ChIP-ChIP_HL60_Human1.99950569
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99332927
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97276246
25ZNF274_21170338_ChIP-Seq_K562_Hela1.89431798
26IRF1_19129219_ChIP-ChIP_H3396_Human1.87956068
27GABP_19822575_ChIP-Seq_HepG2_Human1.83382130
28TTF2_22483619_ChIP-Seq_HELA_Human1.83148390
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81451143
30FOXP3_21729870_ChIP-Seq_TREG_Human1.77930350
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76808605
32XRN2_22483619_ChIP-Seq_HELA_Human1.76576016
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75408404
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73105616
35ELK1_19687146_ChIP-ChIP_HELA_Human1.64742869
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64504557
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59772814
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56849323
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48320110
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43989094
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43683811
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42920449
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42012198
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39872980
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37442951
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32813016
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32399160
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30351117
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29064012
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28353770
51TP53_22573176_ChIP-Seq_HFKS_Human1.24999423
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24702661
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23494169
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.20261884
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.20206408
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.19900450
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13364528
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12550681
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.12109001
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10836494
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.10721997
62NCOR_22424771_ChIP-Seq_293T_Human1.09783110
63TAF2_19829295_ChIP-Seq_ESCs_Human1.09314793
64ERA_21632823_ChIP-Seq_H3396_Human1.08839001
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08703268
66RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08649017
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.08283514
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.06272737
69NANOG_20526341_ChIP-Seq_ESCs_Human1.05866873
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05604050
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04768416
72DCP1A_22483619_ChIP-Seq_HELA_Human1.04077690
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02602723
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.01583853
75EWS_26573619_Chip-Seq_HEK293_Human0.98912986
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97951624
77FUS_26573619_Chip-Seq_HEK293_Human0.97565668
78JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97535539
79REST_21632747_ChIP-Seq_MESCs_Mouse0.97184577
80CIITA_25753668_ChIP-Seq_RAJI_Human0.95959234
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94879586
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94373586
83CTCF_20526341_ChIP-Seq_ESCs_Human0.94046912
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92656117
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.92308314
86KDM5A_27292631_Chip-Seq_BREAST_Human0.91101017
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.89794150
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88269724
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88240356
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.87882191
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.86639655
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.86623548
93RNF2_27304074_Chip-Seq_NSC_Mouse0.86596275
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86092063
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84318071
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.84184613
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.84143977
98P53_21459846_ChIP-Seq_SAOS-2_Human0.83623074
99MYC_19829295_ChIP-Seq_ESCs_Human0.80556247
100AR_20517297_ChIP-Seq_VCAP_Human0.80294994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.65590659
2MP0009379_abnormal_foot_pigmentation4.21070970
3MP0003123_paternal_imprinting3.80454021
4MP0003787_abnormal_imprinting3.64769675
5MP0002653_abnormal_ependyma_morphology2.85223952
6MP0008789_abnormal_olfactory_epithelium2.83403855
7MP0008877_abnormal_DNA_methylation2.10063801
8MP0005646_abnormal_pituitary_gland2.06699441
9MP0003121_genomic_imprinting2.04837308
10MP0004142_abnormal_muscle_tone1.98923260
11MP0006276_abnormal_autonomic_nervous1.98330350
12MP0005394_taste/olfaction_phenotype1.96361807
13MP0005499_abnormal_olfactory_system1.96361807
14MP0001968_abnormal_touch/_nociception1.92788485
15MP0005377_hearing/vestibular/ear_phenot1.90480173
16MP0003878_abnormal_ear_physiology1.90480173
17MP0002138_abnormal_hepatobiliary_system1.83753756
18MP0001293_anophthalmia1.82723270
19MP0001529_abnormal_vocalization1.75024620
20MP0003122_maternal_imprinting1.74483792
21MP0002163_abnormal_gland_morphology1.72491793
22MP0002736_abnormal_nociception_after1.64414378
23MP0002160_abnormal_reproductive_system1.63788685
24MP0002272_abnormal_nervous_system1.62397155
25MP0000372_irregular_coat_pigmentation1.62331163
26MP0000049_abnormal_middle_ear1.62008387
27MP0004885_abnormal_endolymph1.61754962
28MP0001986_abnormal_taste_sensitivity1.59097743
29MP0001984_abnormal_olfaction1.57238668
30MP0001485_abnormal_pinna_reflex1.50784329
31MP0008875_abnormal_xenobiotic_pharmacok1.49852357
32MP0003646_muscle_fatigue1.44181288
33MP0005389_reproductive_system_phenotype1.43922228
34MP0003880_abnormal_central_pattern1.41132967
35MP0008872_abnormal_physiological_respon1.40283188
36MP0000631_abnormal_neuroendocrine_gland1.40206471
37MP0010030_abnormal_orbit_morphology1.39345098
38MP0001905_abnormal_dopamine_level1.39059335
39MP0005551_abnormal_eye_electrophysiolog1.38754190
40MP0002938_white_spotting1.38559239
41MP0004133_heterotaxia1.31575790
42MP0002837_dystrophic_cardiac_calcinosis1.29279044
43MP0000778_abnormal_nervous_system1.28764616
44MP0002557_abnormal_social/conspecific_i1.28700606
45MP0004147_increased_porphyrin_level1.27595772
46MP0002876_abnormal_thyroid_physiology1.23016998
47MP0004145_abnormal_muscle_electrophysio1.22665330
48MP0003186_abnormal_redox_activity1.19647075
49MP0005084_abnormal_gallbladder_morpholo1.19411048
50MP0009745_abnormal_behavioral_response1.19345740
51MP0002102_abnormal_ear_morphology1.17931666
52MP0003136_yellow_coat_color1.16780577
53MP0001873_stomach_inflammation1.14914500
54MP0006072_abnormal_retinal_apoptosis1.13718143
55MP0005360_urolithiasis1.12081165
56MP0001440_abnormal_grooming_behavior1.11757378
57MP0000026_abnormal_inner_ear1.10769685
58MP0002733_abnormal_thermal_nociception1.08179451
59MP0002572_abnormal_emotion/affect_behav1.05410931
60MP0001970_abnormal_pain_threshold1.05406851
61MP0002184_abnormal_innervation1.04901593
62MP0000955_abnormal_spinal_cord1.04716701
63MP0005645_abnormal_hypothalamus_physiol1.03461386
64MP0008775_abnormal_heart_ventricle1.03396073
65MP0005423_abnormal_somatic_nervous1.02945327
66MP0002095_abnormal_skin_pigmentation1.01215637
67MP0003315_abnormal_perineum_morphology1.01048581
68MP0002233_abnormal_nose_morphology1.00757694
69MP0002210_abnormal_sex_determination0.99592652
70MP0005379_endocrine/exocrine_gland_phen0.97595051
71MP0001919_abnormal_reproductive_system0.97276434
72MP0009046_muscle_twitch0.96451724
73MP0003119_abnormal_digestive_system0.95829534
74MP0001486_abnormal_startle_reflex0.95662337
75MP0009053_abnormal_anal_canal0.93677479
76MP0002752_abnormal_somatic_nervous0.93393064
77MP0005195_abnormal_posterior_eye0.93192984
78MP0003718_maternal_effect0.92559334
79MP0008058_abnormal_DNA_repair0.89734817
80MP0003937_abnormal_limbs/digits/tail_de0.86845230
81MP0001963_abnormal_hearing_physiology0.86401949
82MP0000613_abnormal_salivary_gland0.85767223
83MP0002063_abnormal_learning/memory/cond0.83497378
84MP0002638_abnormal_pupillary_reflex0.81302099
85MP0004742_abnormal_vestibular_system0.81268440
86MP0003635_abnormal_synaptic_transmissio0.80492252
87MP0003786_premature_aging0.80386758
88MP0009250_abnormal_appendicular_skeleto0.80274443
89MP0002234_abnormal_pharynx_morphology0.79626687
90MP0000427_abnormal_hair_cycle0.77915007
91MP0003942_abnormal_urinary_system0.77661229
92MP0005636_abnormal_mineral_homeostasis0.75305647
93MP0002735_abnormal_chemical_nociception0.75299085
94MP0002067_abnormal_sensory_capabilities0.73778390
95MP0000230_abnormal_systemic_arterial0.71944814
96MP0001145_abnormal_male_reproductive0.70460485
97MP0000653_abnormal_sex_gland0.69074828
98MP0002882_abnormal_neuron_morphology0.67897387
99MP0006036_abnormal_mitochondrial_physio0.67442424
100MP0003936_abnormal_reproductive_system0.67083141

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.93556055
2Acute necrotizing encephalopathy (HP:0006965)4.46621558
3Abnormality of cells of the erythroid lineage (HP:0012130)4.28400472
4Mitochondrial inheritance (HP:0001427)3.97556917
5Abnormal mitochondria in muscle tissue (HP:0008316)3.93803449
6Pancreatic fibrosis (HP:0100732)3.85007943
7Type II lissencephaly (HP:0007260)3.78796320
8Acute encephalopathy (HP:0006846)3.77223758
9Progressive macrocephaly (HP:0004481)3.61335148
10Increased CSF lactate (HP:0002490)3.61011242
11Macrocytic anemia (HP:0001972)3.52032128
12Abnormal number of erythroid precursors (HP:0012131)3.49190542
13Abnormality of midbrain morphology (HP:0002418)3.40652737
14Molar tooth sign on MRI (HP:0002419)3.40652737
15Pancreatic cysts (HP:0001737)3.29190990
16Hepatic necrosis (HP:0002605)3.29058499
17Hepatocellular necrosis (HP:0001404)3.28105970
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.27898353
19Increased hepatocellular lipid droplets (HP:0006565)3.10888876
20Adrenal hypoplasia (HP:0000835)3.03128220
21Colon cancer (HP:0003003)2.99243548
22Pendular nystagmus (HP:0012043)2.96663554
23True hermaphroditism (HP:0010459)2.90125340
24Lipid accumulation in hepatocytes (HP:0006561)2.87104588
25Medial flaring of the eyebrow (HP:0010747)2.83822983
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80054003
27Cerebral edema (HP:0002181)2.75625253
28Myokymia (HP:0002411)2.75216444
29Abnormal rod and cone electroretinograms (HP:0008323)2.70912748
30Rib fusion (HP:0000902)2.62945736
31Renal Fanconi syndrome (HP:0001994)2.55888728
32Stenosis of the external auditory canal (HP:0000402)2.55665041
33Absent thumb (HP:0009777)2.50378578
34Pallor (HP:0000980)2.47749904
35Sclerocornea (HP:0000647)2.47142457
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.46505602
37Asplenia (HP:0001746)2.45757657
38Optic disc pallor (HP:0000543)2.44852283
39Anencephaly (HP:0002323)2.44173730
40Gait imbalance (HP:0002141)2.44111890
41Increased serum lactate (HP:0002151)2.43932549
42Congenital primary aphakia (HP:0007707)2.43197396
43Congenital stationary night blindness (HP:0007642)2.38111906
44Hyperglycinemia (HP:0002154)2.34744936
45Cerebellar dysplasia (HP:0007033)2.31269559
46Nephrogenic diabetes insipidus (HP:0009806)2.30844250
47Abnormality of alanine metabolism (HP:0010916)2.30630754
48Hyperalaninemia (HP:0003348)2.30630754
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30630754
50Nephronophthisis (HP:0000090)2.29114721
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28117460
52Abnormality of DNA repair (HP:0003254)2.27375696
53Lactic acidosis (HP:0003128)2.24919174
54Retinal dysplasia (HP:0007973)2.24487072
55Septo-optic dysplasia (HP:0100842)2.23920390
56Lissencephaly (HP:0001339)2.18089812
573-Methylglutaconic aciduria (HP:0003535)2.17195689
58Abnormality of the labia minora (HP:0012880)2.16264988
59Increased intramyocellular lipid droplets (HP:0012240)2.11281891
60Cystic liver disease (HP:0006706)2.08497915
61Anophthalmia (HP:0000528)2.08446679
62Pachygyria (HP:0001302)2.08149392
63Postaxial foot polydactyly (HP:0001830)2.06797819
64Type 2 muscle fiber atrophy (HP:0003554)2.05133605
65Renal cortical cysts (HP:0000803)2.05041473
66Exertional dyspnea (HP:0002875)2.02486294
67Abnormality of urine glucose concentration (HP:0011016)1.99663214
68Glycosuria (HP:0003076)1.99663214
69Generalized aminoaciduria (HP:0002909)1.99494977
70Respiratory difficulties (HP:0002880)1.99431604
71Exercise intolerance (HP:0003546)1.98756421
72Abnormal respiratory motile cilium morphology (HP:0005938)1.96098884
73Abnormal respiratory epithelium morphology (HP:0012253)1.96098884
74Depressed nasal ridge (HP:0000457)1.95116951
75Abolished electroretinogram (ERG) (HP:0000550)1.95081716
76Respiratory failure (HP:0002878)1.92554510
77Abnormality of the renal medulla (HP:0100957)1.92319633
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.89969768
79Preaxial hand polydactyly (HP:0001177)1.89548591
80Aplastic anemia (HP:0001915)1.88409910
81Abnormality of magnesium homeostasis (HP:0004921)1.88159040
82Anterior segment dysgenesis (HP:0007700)1.87731615
83Attenuation of retinal blood vessels (HP:0007843)1.84819019
84Leukodystrophy (HP:0002415)1.84816866
85Hyperphosphaturia (HP:0003109)1.83377258
86Muscle fiber atrophy (HP:0100295)1.81426550
87Median cleft lip (HP:0000161)1.80356212
88Severe muscular hypotonia (HP:0006829)1.79701333
89Forearm undergrowth (HP:0009821)1.78533416
90Lethargy (HP:0001254)1.77889364
91Hypoplasia of the radius (HP:0002984)1.77869740
92Hypoplasia of the ulna (HP:0003022)1.77689472
93Poor coordination (HP:0002370)1.74378924
94Holoprosencephaly (HP:0001360)1.73947771
95Abnormality of the renal cortex (HP:0011035)1.73686840
96Horseshoe kidney (HP:0000085)1.72846948
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.72095446
98Congenital hepatic fibrosis (HP:0002612)1.71467617
99Vaginal atresia (HP:0000148)1.71251587
100Methylmalonic acidemia (HP:0002912)1.69998397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.85175915
2WNK43.16834361
3ZAK3.02600891
4ARAF2.80133346
5NME22.75049655
6CDK192.64851034
7STK162.63717983
8TLK12.51281769
9BCKDK2.34753998
10LIMK12.22436298
11DYRK22.21648350
12FRK2.18176009
13PIM22.14453229
14TIE11.95891433
15ADRBK21.94936750
16TAF11.79873509
17VRK11.77470250
18PDK21.70076544
19GRK11.65417895
20NUAK11.59501322
21MAP4K21.49782370
22TRIM281.49599987
23TXK1.42980119
24EPHB21.38745617
25PIK3CA1.38487318
26MAP2K71.38048007
27BRAF1.36719306
28CASK1.31852274
29PHKG11.31451349
30PHKG21.31451349
31TESK21.27081676
32STK391.26591715
33AURKA1.23209970
34LRRK21.22873477
35BMPR1B1.20346632
36MAP3K111.11639070
37TESK11.06087992
38INSRR1.00356000
39NME10.99345289
40TNIK0.98108768
41CDK80.97871442
42CSNK1G20.97383848
43CDC70.93836019
44PLK10.90915123
45CSNK1G30.89057427
46NEK10.87779902
47PRKCG0.87681569
48PLK30.86392311
49PINK10.85941611
50WNK10.85238184
51EPHA40.84711870
52CHEK20.82525448
53RPS6KA50.78109261
54DAPK30.77718506
55ADRBK10.77512177
56PRKCI0.77087870
57DAPK20.73433956
58TNK20.72279629
59CSNK1G10.70507431
60DAPK10.70099406
61NTRK20.67191861
62AURKB0.65744717
63CSNK1A1L0.63981921
64MINK10.61772410
65CAMK10.61638274
66GRK50.60769569
67WNK30.60529927
68MAP3K90.59962013
69ABL20.59597978
70CSNK2A20.59102305
71SRPK10.57827544
72PASK0.54817248
73PLK20.54124841
74STK110.50233359
75CSNK2A10.49634878
76OXSR10.47897506
77PRKACA0.47489844
78BUB10.46740572
79ATR0.46640838
80EPHA20.46291645
81RPS6KA60.46108386
82TGFBR10.46080453
83MST40.45871223
84PRKCQ0.45618522
85MAP2K60.45233769
86TAOK30.44518163
87MOS0.44010988
88TYRO30.43359361
89CAMKK20.42014358
90LMTK20.41841124
91DYRK30.41693576
92MAP3K40.39214614
93MAP3K120.38217477
94OBSCN0.36117188
95PIM10.35754901
96CAMK40.35335816
97PLK40.34178691
98DYRK1B0.33609152
99MUSK0.33146569
100RPS6KC10.31760410

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.34642645
2Oxidative phosphorylation_Homo sapiens_hsa001904.05967311
3Parkinsons disease_Homo sapiens_hsa050123.43577890
4RNA polymerase_Homo sapiens_hsa030203.19456188
5Proteasome_Homo sapiens_hsa030503.09930734
6Huntingtons disease_Homo sapiens_hsa050162.57787099
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37769558
8Cardiac muscle contraction_Homo sapiens_hsa042602.30093897
9Alzheimers disease_Homo sapiens_hsa050102.26529484
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01314511
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.00847375
12Pyrimidine metabolism_Homo sapiens_hsa002401.93116617
13Mismatch repair_Homo sapiens_hsa034301.85531501
14Protein export_Homo sapiens_hsa030601.79621440
15Sulfur relay system_Homo sapiens_hsa041221.79493741
16Homologous recombination_Homo sapiens_hsa034401.77668177
17Basal transcription factors_Homo sapiens_hsa030221.73043992
18Nucleotide excision repair_Homo sapiens_hsa034201.70667524
19Phototransduction_Homo sapiens_hsa047441.63198764
20DNA replication_Homo sapiens_hsa030301.57295074
21One carbon pool by folate_Homo sapiens_hsa006701.50084717
22Base excision repair_Homo sapiens_hsa034101.48623842
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43574216
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42445034
25RNA degradation_Homo sapiens_hsa030181.40382009
26Folate biosynthesis_Homo sapiens_hsa007901.27660942
27Linoleic acid metabolism_Homo sapiens_hsa005911.26570534
28Purine metabolism_Homo sapiens_hsa002301.24473698
29Fanconi anemia pathway_Homo sapiens_hsa034601.22697832
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15683745
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12691558
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08079337
33Butanoate metabolism_Homo sapiens_hsa006501.06234632
34Peroxisome_Homo sapiens_hsa041461.04236916
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02958074
36Nicotine addiction_Homo sapiens_hsa050331.00661919
37Asthma_Homo sapiens_hsa053100.99872944
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.99260230
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94352295
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92100053
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89637900
42Nitrogen metabolism_Homo sapiens_hsa009100.84425454
43RNA transport_Homo sapiens_hsa030130.83899814
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81868439
45Metabolic pathways_Homo sapiens_hsa011000.77976588
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.77502456
47Basal cell carcinoma_Homo sapiens_hsa052170.76763362
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75922683
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74259713
50Propanoate metabolism_Homo sapiens_hsa006400.73677667
51Hedgehog signaling pathway_Homo sapiens_hsa043400.73456925
52Glutathione metabolism_Homo sapiens_hsa004800.72983689
53Olfactory transduction_Homo sapiens_hsa047400.72731058
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71181854
55Spliceosome_Homo sapiens_hsa030400.70557611
56Pyruvate metabolism_Homo sapiens_hsa006200.69440249
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.68944142
58Steroid biosynthesis_Homo sapiens_hsa001000.66717776
59Arachidonic acid metabolism_Homo sapiens_hsa005900.63197974
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.60722707
61Fatty acid elongation_Homo sapiens_hsa000620.58984256
62Chemical carcinogenesis_Homo sapiens_hsa052040.57029749
63Tryptophan metabolism_Homo sapiens_hsa003800.56754312
64Collecting duct acid secretion_Homo sapiens_hsa049660.56608743
65p53 signaling pathway_Homo sapiens_hsa041150.56428623
66Fat digestion and absorption_Homo sapiens_hsa049750.55035925
67Caffeine metabolism_Homo sapiens_hsa002320.54509949
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54450667
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53281416
70Ether lipid metabolism_Homo sapiens_hsa005650.53137307
71Arginine and proline metabolism_Homo sapiens_hsa003300.52894954
72Salivary secretion_Homo sapiens_hsa049700.52672827
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52169886
74Regulation of autophagy_Homo sapiens_hsa041400.50013482
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49353526
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49228097
77Allograft rejection_Homo sapiens_hsa053300.49083382
78Retinol metabolism_Homo sapiens_hsa008300.48505317
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.44568028
80Selenocompound metabolism_Homo sapiens_hsa004500.44217291
81Autoimmune thyroid disease_Homo sapiens_hsa053200.43954222
82Taste transduction_Homo sapiens_hsa047420.40530611
83Morphine addiction_Homo sapiens_hsa050320.38858989
84Insulin secretion_Homo sapiens_hsa049110.37438244
85Biosynthesis of amino acids_Homo sapiens_hsa012300.36394454
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36214469
87Carbon metabolism_Homo sapiens_hsa012000.33981434
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33787139
89beta-Alanine metabolism_Homo sapiens_hsa004100.33687175
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33286000
91Synaptic vesicle cycle_Homo sapiens_hsa047210.32146607
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31906949
93Type I diabetes mellitus_Homo sapiens_hsa049400.28215145
94Hippo signaling pathway_Homo sapiens_hsa043900.26006544
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.23690447
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20525689
97Wnt signaling pathway_Homo sapiens_hsa043100.20417233
98GABAergic synapse_Homo sapiens_hsa047270.19648977
99Primary immunodeficiency_Homo sapiens_hsa053400.18392606
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16751884

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