RPSAP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.99871281
2DNA deamination (GO:0045006)6.29338250
3cytidine metabolic process (GO:0046087)5.58942309
4cytidine catabolic process (GO:0006216)5.58942309
5cytidine deamination (GO:0009972)5.58942309
6viral transcription (GO:0019083)5.58167080
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.48364065
8translational termination (GO:0006415)5.34353024
9ATP synthesis coupled proton transport (GO:0015986)4.90890106
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90890106
11translational elongation (GO:0006414)4.85791002
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83019485
13pyrimidine ribonucleoside catabolic process (GO:0046133)4.70921446
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69104842
15cotranslational protein targeting to membrane (GO:0006613)4.60821888
16protein targeting to ER (GO:0045047)4.59970958
17ribosomal small subunit biogenesis (GO:0042274)4.45680327
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37908443
19protein localization to endoplasmic reticulum (GO:0070972)4.32782124
20maturation of SSU-rRNA (GO:0030490)4.18526027
21viral life cycle (GO:0019058)4.04015862
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04005778
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03607055
24cellular protein complex disassembly (GO:0043624)4.01280763
25ribosomal large subunit biogenesis (GO:0042273)3.91030360
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.84130538
27respiratory electron transport chain (GO:0022904)3.81797072
28translational initiation (GO:0006413)3.80727619
29electron transport chain (GO:0022900)3.78542829
30chaperone-mediated protein transport (GO:0072321)3.69425958
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.59018152
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58303877
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58303877
34protein complex biogenesis (GO:0070271)3.54524204
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.54210298
36protein neddylation (GO:0045116)3.52483105
37metallo-sulfur cluster assembly (GO:0031163)3.43828319
38iron-sulfur cluster assembly (GO:0016226)3.43828319
39proteasome assembly (GO:0043248)3.42562123
40translation (GO:0006412)3.37766094
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.31719867
42NADH dehydrogenase complex assembly (GO:0010257)3.31719867
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31719867
44actin nucleation (GO:0045010)3.30171153
45response to pheromone (GO:0019236)3.27026123
46protein complex disassembly (GO:0043241)3.26128678
47pyrimidine nucleotide catabolic process (GO:0006244)3.23419989
48behavioral response to nicotine (GO:0035095)3.16603256
49macromolecular complex disassembly (GO:0032984)3.13541420
50GTP biosynthetic process (GO:0006183)3.12808342
51mitochondrial respiratory chain complex assembly (GO:0033108)3.11804906
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11638414
53ncRNA 3-end processing (GO:0043628)3.10446672
54water-soluble vitamin biosynthetic process (GO:0042364)3.07159941
55sequestering of actin monomers (GO:0042989)3.03251003
56base-excision repair, AP site formation (GO:0006285)3.01316130
57pseudouridine synthesis (GO:0001522)2.99794464
58cellular component biogenesis (GO:0044085)2.96710805
59positive regulation of B cell differentiation (GO:0045579)2.96104283
60ubiquinone biosynthetic process (GO:0006744)2.96078209
61respiratory chain complex IV assembly (GO:0008535)2.94158587
62protein targeting to membrane (GO:0006612)2.92786243
63negative regulation of T cell apoptotic process (GO:0070233)2.92376058
64ribonucleoprotein complex biogenesis (GO:0022613)2.92168708
65deoxyribonucleotide catabolic process (GO:0009264)2.89664159
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88111717
67platelet dense granule organization (GO:0060155)2.87797133
68regulation of cellular amino acid metabolic process (GO:0006521)2.85960729
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81564313
70pyrimidine nucleoside catabolic process (GO:0046135)2.81435346
71regulation of activation of Janus kinase activity (GO:0010533)2.80756049
72nuclear-transcribed mRNA catabolic process (GO:0000956)2.80580079
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80224884
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78972692
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78742230
76cytolysis (GO:0019835)2.77897102
77deoxyribose phosphate catabolic process (GO:0046386)2.77132599
78cytochrome complex assembly (GO:0017004)2.75761072
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75012172
80UTP biosynthetic process (GO:0006228)2.74646844
81pyrimidine ribonucleoside metabolic process (GO:0046131)2.73500507
82positive regulation of T cell apoptotic process (GO:0070234)2.72800140
83hydrogen ion transmembrane transport (GO:1902600)2.72433873
84axoneme assembly (GO:0035082)2.68905305
85UTP metabolic process (GO:0046051)2.68878537
86ATP biosynthetic process (GO:0006754)2.68287750
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67511545
88purine nucleotide salvage (GO:0032261)2.62697375
89aggressive behavior (GO:0002118)2.61513440
90mRNA catabolic process (GO:0006402)2.60248179
91positive regulation of calcium-mediated signaling (GO:0050850)2.60130720
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58357093
93ubiquinone metabolic process (GO:0006743)2.57958275
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57039726
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56909223
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56909223
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56909223
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55549445
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55549445
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54743844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.67377225
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.58106715
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30506845
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16098350
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06863156
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72172715
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72001535
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.68143197
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.67779416
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63526687
11VDR_22108803_ChIP-Seq_LS180_Human2.58791947
12EZH2_22144423_ChIP-Seq_EOC_Human2.51299925
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47315430
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.45487579
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.36428927
16VDR_23849224_ChIP-Seq_CD4+_Human2.33368847
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26578880
18IGF1R_20145208_ChIP-Seq_DFB_Human2.14083443
19ZNF274_21170338_ChIP-Seq_K562_Hela2.04227694
20FOXP3_21729870_ChIP-Seq_TREG_Human2.02018043
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00709203
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.87252169
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70416717
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69738477
25MYC_18940864_ChIP-ChIP_HL60_Human1.65554169
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.60557071
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.59621936
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59198454
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57999151
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.57435273
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57344796
32EWS_26573619_Chip-Seq_HEK293_Human1.53982306
33TP53_22573176_ChIP-Seq_HFKS_Human1.51359111
34ELK1_19687146_ChIP-ChIP_HELA_Human1.46875909
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43986982
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42355636
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41683713
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40839616
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.40839616
40NANOG_20526341_ChIP-Seq_ESCs_Human1.40835309
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36185751
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36143228
43MYB_26560356_Chip-Seq_TH2_Human1.35978784
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35463311
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.34601720
46FUS_26573619_Chip-Seq_HEK293_Human1.33964275
47AR_20517297_ChIP-Seq_VCAP_Human1.33850894
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33480962
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32908241
50NCOR_22424771_ChIP-Seq_293T_Human1.32885697
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31739313
52TAF2_19829295_ChIP-Seq_ESCs_Human1.29629782
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29474713
54TTF2_22483619_ChIP-Seq_HELA_Human1.24593303
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23951209
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.23213409
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22864638
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.21306377
59BCL6_27268052_Chip-Seq_Bcells_Human1.19618579
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19019553
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14770193
62IRF1_19129219_ChIP-ChIP_H3396_Human1.14029565
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13237289
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12993419
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.12906834
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.12905242
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12480102
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11890437
69P53_21459846_ChIP-Seq_SAOS-2_Human1.10191436
70NANOG_19829295_ChIP-Seq_ESCs_Human1.09445208
71SOX2_19829295_ChIP-Seq_ESCs_Human1.09445208
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08898935
73MYC_19829295_ChIP-Seq_ESCs_Human1.08074375
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08022035
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08011427
76HTT_18923047_ChIP-ChIP_STHdh_Human1.07291119
77ERG_20517297_ChIP-Seq_VCAP_Human1.07268646
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06522912
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06219292
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04477213
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03958547
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03470914
83GATA3_26560356_Chip-Seq_TH2_Human1.03234906
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03181827
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02758799
86XRN2_22483619_ChIP-Seq_HELA_Human1.02129445
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01274349
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00951558
89P300_27268052_Chip-Seq_Bcells_Human0.98915049
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98654039
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98189871
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97005921
93ERA_21632823_ChIP-Seq_H3396_Human0.96247991
94GABP_19822575_ChIP-Seq_HepG2_Human0.95542110
95RUNX_20019798_ChIP-Seq_JUKART_Human0.93102351
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.90846811
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89534028
98GATA3_27048872_Chip-Seq_THYMUS_Human0.89351979
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89259579
100CBP_20019798_ChIP-Seq_JUKART_Human0.87555892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.67348879
2MP0005671_abnormal_response_to3.79893473
3MP0006292_abnormal_olfactory_placode3.10653568
4MP0005646_abnormal_pituitary_gland2.32619037
5MP0001873_stomach_inflammation2.11302723
6MP0003878_abnormal_ear_physiology2.11041091
7MP0005377_hearing/vestibular/ear_phenot2.11041091
8MP0009785_altered_susceptibility_to2.08025884
9MP0009333_abnormal_splenocyte_physiolog2.06052552
10MP0001835_abnormal_antigen_presentation2.05456756
11MP0004147_increased_porphyrin_level2.04174616
12MP0002102_abnormal_ear_morphology1.96186268
13MP0005645_abnormal_hypothalamus_physiol1.88141514
14MP0003646_muscle_fatigue1.87890673
15MP0001764_abnormal_homeostasis1.86170829
16MP0002160_abnormal_reproductive_system1.80234159
17MP0003763_abnormal_thymus_physiology1.80061529
18MP0008872_abnormal_physiological_respon1.77687432
19MP0002138_abnormal_hepatobiliary_system1.76188019
20MP0005084_abnormal_gallbladder_morpholo1.75651739
21MP0008877_abnormal_DNA_methylation1.74383702
22MP0002837_dystrophic_cardiac_calcinosis1.69639857
23MP0006072_abnormal_retinal_apoptosis1.67356071
24MP0000372_irregular_coat_pigmentation1.61278627
25MP0001800_abnormal_humoral_immune1.60105983
26MP0005075_abnormal_melanosome_morpholog1.57153469
27MP0005389_reproductive_system_phenotype1.57126113
28MP0001485_abnormal_pinna_reflex1.56184063
29MP0005551_abnormal_eye_electrophysiolog1.55855353
30MP0002736_abnormal_nociception_after1.55218659
31MP0008995_early_reproductive_senescence1.52366292
32MP0001968_abnormal_touch/_nociception1.50697197
33MP0001188_hyperpigmentation1.46767809
34MP0002095_abnormal_skin_pigmentation1.44898805
35MP0002163_abnormal_gland_morphology1.41151219
36MP0005000_abnormal_immune_tolerance1.38043306
37MP0004885_abnormal_endolymph1.37594490
38MP0003806_abnormal_nucleotide_metabolis1.34604328
39MP0002148_abnormal_hypersensitivity_rea1.34480129
40MP0002876_abnormal_thyroid_physiology1.34202823
41MP0002420_abnormal_adaptive_immunity1.32675517
42MP0001905_abnormal_dopamine_level1.32256094
43MP0001790_abnormal_immune_system1.31229082
44MP0005387_immune_system_phenotype1.31229082
45MP0003567_abnormal_fetal_cardiomyocyte1.30789150
46MP0002723_abnormal_immune_serum1.30237414
47MP0002653_abnormal_ependyma_morphology1.29086231
48MP0001819_abnormal_immune_cell1.27837873
49MP0002638_abnormal_pupillary_reflex1.26763182
50MP0003786_premature_aging1.26323439
51MP0002132_abnormal_respiratory_system1.24461740
52MP0005025_abnormal_response_to1.24338792
53MP0001919_abnormal_reproductive_system1.23064784
54MP0002166_altered_tumor_susceptibility1.21344308
55MP0004142_abnormal_muscle_tone1.21020997
56MP0008875_abnormal_xenobiotic_pharmacok1.19771721
57MP0000678_abnormal_parathyroid_gland1.16563280
58MP0008789_abnormal_olfactory_epithelium1.15621097
59MP0002398_abnormal_bone_marrow1.15073103
60MP0000716_abnormal_immune_system1.13525153
61MP0000685_abnormal_immune_system1.11525515
62MP0006276_abnormal_autonomic_nervous1.11118004
63MP0003787_abnormal_imprinting1.10943741
64MP0001986_abnormal_taste_sensitivity1.09260656
65MP0002006_tumorigenesis1.08635695
66MP0010155_abnormal_intestine_physiology1.01216236
67MP0005253_abnormal_eye_physiology0.99718333
68MP0002452_abnormal_antigen_presenting0.98790196
69MP0002272_abnormal_nervous_system0.98244741
70MP0000689_abnormal_spleen_morphology0.97562840
71MP0003123_paternal_imprinting0.94990625
72MP0001293_anophthalmia0.93196828
73MP0004742_abnormal_vestibular_system0.91838238
74MP0001529_abnormal_vocalization0.91530579
75MP0000703_abnormal_thymus_morphology0.91442081
76MP0005636_abnormal_mineral_homeostasis0.91403194
77MP0000049_abnormal_middle_ear0.90657460
78MP0002429_abnormal_blood_cell0.90140887
79MP0006036_abnormal_mitochondrial_physio0.90073965
80MP0002405_respiratory_system_inflammati0.87806344
81MP0002277_abnormal_respiratory_mucosa0.87240175
82MP0002722_abnormal_immune_system0.87130529
83MP0001348_abnormal_lacrimal_gland0.85295088
84MP0005410_abnormal_fertilization0.84879716
85MP0005379_endocrine/exocrine_gland_phen0.84247734
86MP0000631_abnormal_neuroendocrine_gland0.84168447
87MP0003866_abnormal_defecation0.82738308
88MP0005464_abnormal_platelet_physiology0.81438460
89MP0004145_abnormal_muscle_electrophysio0.80450778
90MP0001963_abnormal_hearing_physiology0.79816282
91MP0005085_abnormal_gallbladder_physiolo0.78925296
92MP0005360_urolithiasis0.78690323
93MP0001845_abnormal_inflammatory_respons0.76918362
94MP0001661_extended_life_span0.75989846
95MP0003880_abnormal_central_pattern0.73902144
96MP0000026_abnormal_inner_ear0.73830445
97MP0001663_abnormal_digestive_system0.71951009
98MP0000681_abnormal_thyroid_gland0.71832207
99MP0002933_joint_inflammation0.71764470
100MP0002693_abnormal_pancreas_physiology0.70822775

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.03550451
2Mitochondrial inheritance (HP:0001427)4.00146209
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.80627835
4Congenital stationary night blindness (HP:0007642)3.75485019
5Increased hepatocellular lipid droplets (HP:0006565)3.72210968
6Reticulocytopenia (HP:0001896)3.67961470
7Abnormal mitochondria in muscle tissue (HP:0008316)3.64854384
8Abnormality of B cell number (HP:0010975)3.57744449
9Increased CSF lactate (HP:0002490)3.43741137
10Aplastic anemia (HP:0001915)3.39367195
11Abnormal rod and cone electroretinograms (HP:0008323)3.36265237
12B lymphocytopenia (HP:0010976)3.33093843
13Acute encephalopathy (HP:0006846)3.30332346
14Increased intramyocellular lipid droplets (HP:0012240)3.29574646
15Hepatocellular necrosis (HP:0001404)3.29157086
16Lipid accumulation in hepatocytes (HP:0006561)3.28525355
17Renal Fanconi syndrome (HP:0001994)3.24689950
18Progressive macrocephaly (HP:0004481)3.21377153
19Abnormality of cells of the erythroid lineage (HP:0012130)3.21067054
20Severe combined immunodeficiency (HP:0004430)3.15843159
21Elevated erythrocyte sedimentation rate (HP:0003565)3.09945224
22Hepatic necrosis (HP:0002605)2.99756922
23Macrocytic anemia (HP:0001972)2.92033011
24Hypoproteinemia (HP:0003075)2.87788010
25IgG deficiency (HP:0004315)2.85671542
26Cerebral edema (HP:0002181)2.82139149
27Pancreatic cysts (HP:0001737)2.80944104
28Pancreatic fibrosis (HP:0100732)2.75641883
29Abnormal number of erythroid precursors (HP:0012131)2.73499851
30Molar tooth sign on MRI (HP:0002419)2.73201287
31Abnormality of midbrain morphology (HP:0002418)2.73201287
32True hermaphroditism (HP:0010459)2.70202509
33Increased muscle lipid content (HP:0009058)2.68034451
34Constricted visual fields (HP:0001133)2.65023192
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63019349
36Exertional dyspnea (HP:0002875)2.61723152
37Asplenia (HP:0001746)2.60502905
38T lymphocytopenia (HP:0005403)2.57996240
39Abolished electroretinogram (ERG) (HP:0000550)2.57381222
40Pallor (HP:0000980)2.56548941
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.54812312
42Optic disc pallor (HP:0000543)2.53228284
43Thyroiditis (HP:0100646)2.52369272
44Abnormality of T cell number (HP:0011839)2.51412097
45Combined immunodeficiency (HP:0005387)2.41347295
46Increased serum lactate (HP:0002151)2.41222655
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38786884
48Attenuation of retinal blood vessels (HP:0007843)2.37059404
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33784372
503-Methylglutaconic aciduria (HP:0003535)2.33228080
51Absent/shortened dynein arms (HP:0200106)2.33054745
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.33054745
53Glycosuria (HP:0003076)2.32591490
54Abnormality of urine glucose concentration (HP:0011016)2.32591490
55Medial flaring of the eyebrow (HP:0010747)2.32327620
56Reduced antithrombin III activity (HP:0001976)2.31897777
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31403683
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31403683
59Agammaglobulinemia (HP:0004432)2.28752219
60Hyperglycinemia (HP:0002154)2.28256717
61Stenosis of the external auditory canal (HP:0000402)2.28168312
62Lactic acidosis (HP:0003128)2.28071653
63Decreased central vision (HP:0007663)2.23902429
64Increased IgM level (HP:0003496)2.23507192
65Abnormal ciliary motility (HP:0012262)2.19654066
66Abnormal respiratory motile cilium morphology (HP:0005938)2.17787548
67Abnormal respiratory epithelium morphology (HP:0012253)2.17787548
68Chronic sinusitis (HP:0011109)2.16989075
69Panhypogammaglobulinemia (HP:0003139)2.14871017
70Lethargy (HP:0001254)2.13741921
71Hyperphosphaturia (HP:0003109)2.11679905
72Absent thumb (HP:0009777)2.11611008
73Pancytopenia (HP:0001876)2.11285382
74Abnormality of DNA repair (HP:0003254)2.10282774
75Autoimmune hemolytic anemia (HP:0001890)2.09101439
76Abnormality of renal resorption (HP:0011038)2.05837544
77Methylmalonic acidemia (HP:0002912)2.05528479
78Abnormality of the renal collecting system (HP:0004742)2.04803654
79Respiratory difficulties (HP:0002880)2.03052255
80Congenital primary aphakia (HP:0007707)2.02241036
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.01772325
82Pendular nystagmus (HP:0012043)2.00470544
83Abnormality of eosinophils (HP:0001879)1.98409651
84Hypoplasia of the thymus (HP:0000778)1.97581513
85Abnormal protein glycosylation (HP:0012346)1.97167593
86Abnormal glycosylation (HP:0012345)1.97167593
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97167593
88Abnormal protein N-linked glycosylation (HP:0012347)1.97167593
89Abnormality of the phalanges of the 5th finger (HP:0004213)1.97011779
90Gait imbalance (HP:0002141)1.95768622
91Abnormal respiratory motile cilium physiology (HP:0012261)1.95623165
92Nephronophthisis (HP:0000090)1.95200791
93Nephrogenic diabetes insipidus (HP:0009806)1.93949558
94Methylmalonic aciduria (HP:0012120)1.93430379
95Exercise intolerance (HP:0003546)1.92674508
96Type 2 muscle fiber atrophy (HP:0003554)1.91537536
97Abnormality of T cells (HP:0002843)1.91027344
98Generalized aminoaciduria (HP:0002909)1.88256829
99Dyschromatopsia (HP:0007641)1.87471091
100Abnormality of macular pigmentation (HP:0008002)1.83514178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.99083167
2TESK23.86428904
3BCKDK3.37942888
4TXK3.08905874
5VRK23.02750043
6CDK192.89907350
7GRK12.74142007
8ZAK2.68779595
9MAP4K12.64458755
10ADRBK22.39549643
11MAP3K112.33768123
12TAOK32.08171339
13MAP4K22.04012690
14STK161.90134341
15TIE11.86492375
16NUAK11.82928657
17VRK11.81685987
18TLK11.76772549
19ITK1.65274579
20PASK1.63885235
21TAF11.48363305
22TEC1.46859067
23SCYL21.32089995
24SYK1.30088293
25MAP3K121.26844809
26WNK41.21406458
27PINK11.18676322
28DYRK21.18636477
29GRK61.17387291
30PRKCQ1.17248209
31LIMK11.16322996
32BMPR1B1.10652122
33PIK3CA0.99953096
34TNK20.99151159
35NME20.98582338
36BTK0.96334632
37EIF2AK30.93744362
38PLK40.91655544
39NME10.91456893
40IKBKE0.85727241
41FRK0.84750587
42PBK0.83984759
43ADRBK10.83779879
44WNK30.83305552
45LCK0.82341824
46MAP2K60.80928506
47INSRR0.79675020
48DAPK10.79057594
49RPS6KA40.77840612
50ACVR1B0.77606903
51MST40.76898410
52PIM20.73778973
53FES0.73070349
54AURKA0.69947591
55RPS6KA50.69367274
56MUSK0.68441858
57PIK3CG0.67440142
58LYN0.64388712
59KIT0.62539759
60CDC70.62103893
61PIM10.61734379
62MAP2K70.60565081
63IKBKB0.60375680
64STK390.59309908
65CSNK1G10.57950220
66DAPK30.55355647
67DAPK20.53365947
68CSNK2A20.52976260
69OBSCN0.52532924
70ZAP700.51862333
71PRKCH0.51203013
72CSF1R0.50875371
73CSNK1G30.50547463
74CSNK2A10.49868682
75CDK30.49683580
76MAP3K50.49411339
77GRK70.47987258
78MAPKAPK30.46839462
79PLK10.46185428
80PRKACA0.44391879
81PRKCA0.44036899
82LRRK20.43810316
83NLK0.43451432
84RPS6KB20.40631693
85CSNK1G20.40286656
86BUB10.38853370
87AURKB0.38356961
88OXSR10.37915494
89RPS6KA60.37074675
90PRKCD0.35831581
91CSK0.35525187
92ATR0.33811953
93JAK30.33479242
94MAP3K40.33114780
95PRKCG0.31754189
96TESK10.30745981
97CSNK1A10.30744822
98PRKCE0.30478293
99TBK10.29690716
100IGF1R0.29637361

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.91456532
2Primary immunodeficiency_Homo sapiens_hsa053403.83264987
3Proteasome_Homo sapiens_hsa030503.82009242
4Oxidative phosphorylation_Homo sapiens_hsa001903.80855181
5Parkinsons disease_Homo sapiens_hsa050123.18877369
6RNA polymerase_Homo sapiens_hsa030202.39510765
7Huntingtons disease_Homo sapiens_hsa050162.14430616
8Alzheimers disease_Homo sapiens_hsa050102.06214644
9Phototransduction_Homo sapiens_hsa047442.03598110
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98580157
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85748688
12Cardiac muscle contraction_Homo sapiens_hsa042601.81597869
13Allograft rejection_Homo sapiens_hsa053301.79415333
14Graft-versus-host disease_Homo sapiens_hsa053321.73887883
15Autoimmune thyroid disease_Homo sapiens_hsa053201.71082687
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67284766
17Linoleic acid metabolism_Homo sapiens_hsa005911.65225871
18Antigen processing and presentation_Homo sapiens_hsa046121.59045558
19Pyrimidine metabolism_Homo sapiens_hsa002401.55428753
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54303481
21Protein export_Homo sapiens_hsa030601.53862961
22Homologous recombination_Homo sapiens_hsa034401.50726278
23Hematopoietic cell lineage_Homo sapiens_hsa046401.50428753
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48424156
25Asthma_Homo sapiens_hsa053101.47493508
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43940567
27Fanconi anemia pathway_Homo sapiens_hsa034601.41467875
28Type I diabetes mellitus_Homo sapiens_hsa049401.40093355
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.33685367
30Peroxisome_Homo sapiens_hsa041461.30117584
31RNA degradation_Homo sapiens_hsa030181.22842674
32Caffeine metabolism_Homo sapiens_hsa002321.20437747
33DNA replication_Homo sapiens_hsa030301.08710927
34Nitrogen metabolism_Homo sapiens_hsa009101.08278779
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06671034
36Olfactory transduction_Homo sapiens_hsa047401.05145310
37Base excision repair_Homo sapiens_hsa034101.04346461
38Butanoate metabolism_Homo sapiens_hsa006501.02958422
39Purine metabolism_Homo sapiens_hsa002301.02211819
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00582161
41Selenocompound metabolism_Homo sapiens_hsa004500.99965125
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.95741506
43Ether lipid metabolism_Homo sapiens_hsa005650.95427523
44Retinol metabolism_Homo sapiens_hsa008300.94428923
45One carbon pool by folate_Homo sapiens_hsa006700.92081319
46Fat digestion and absorption_Homo sapiens_hsa049750.91908689
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91763209
48T cell receptor signaling pathway_Homo sapiens_hsa046600.88444513
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86898471
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86080927
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.85740380
52Nucleotide excision repair_Homo sapiens_hsa034200.84324590
53Chemical carcinogenesis_Homo sapiens_hsa052040.83888737
54Arachidonic acid metabolism_Homo sapiens_hsa005900.82915618
55Mismatch repair_Homo sapiens_hsa034300.81931300
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80373433
57Basal transcription factors_Homo sapiens_hsa030220.76333993
58Rheumatoid arthritis_Homo sapiens_hsa053230.74002429
59Propanoate metabolism_Homo sapiens_hsa006400.73375286
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.73088782
61Metabolic pathways_Homo sapiens_hsa011000.71946788
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71829986
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71825598
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71603695
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71517619
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67737516
67RNA transport_Homo sapiens_hsa030130.66407755
68Spliceosome_Homo sapiens_hsa030400.63685524
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62210052
70Tryptophan metabolism_Homo sapiens_hsa003800.61675736
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60473721
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.57488495
73Sulfur relay system_Homo sapiens_hsa041220.57279170
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56866667
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.56352672
76Systemic lupus erythematosus_Homo sapiens_hsa053220.53893633
77Sulfur metabolism_Homo sapiens_hsa009200.52631474
78Nicotine addiction_Homo sapiens_hsa050330.51730936
79Collecting duct acid secretion_Homo sapiens_hsa049660.51565137
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47981837
81Taste transduction_Homo sapiens_hsa047420.43732751
82Vitamin digestion and absorption_Homo sapiens_hsa049770.43280120
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41612950
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40740521
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39636703
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38369012
87Regulation of autophagy_Homo sapiens_hsa041400.34342105
88Glutathione metabolism_Homo sapiens_hsa004800.33892671
89Measles_Homo sapiens_hsa051620.33080153
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.31137910
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30676149
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.28701943
93Malaria_Homo sapiens_hsa051440.27203958
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25598118
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24891869
96Glycerolipid metabolism_Homo sapiens_hsa005610.23693345
97Ovarian steroidogenesis_Homo sapiens_hsa049130.23179495
98Fatty acid degradation_Homo sapiens_hsa000710.20801139
99Serotonergic synapse_Homo sapiens_hsa047260.20199860
100Pyruvate metabolism_Homo sapiens_hsa006200.18796392

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