RPSAP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of nuclear cell cycle DNA replication (GO:0033262)5.29364924
2CENP-A containing nucleosome assembly (GO:0034080)5.28250119
3DNA deamination (GO:0045006)5.22199090
4chromatin remodeling at centromere (GO:0031055)5.13563667
5rRNA modification (GO:0000154)4.89738157
6resolution of meiotic recombination intermediates (GO:0000712)4.53530795
7signal peptide processing (GO:0006465)4.35342941
8histone exchange (GO:0043486)4.33414034
9cullin deneddylation (GO:0010388)4.28860140
10rRNA methylation (GO:0031167)4.23080337
11negative regulation of DNA-dependent DNA replication (GO:2000104)4.21960330
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.16329240
13kinetochore assembly (GO:0051382)4.10490406
14kinetochore organization (GO:0051383)4.10297155
15protein deneddylation (GO:0000338)3.98075250
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94384029
17DNA replication-independent nucleosome assembly (GO:0006336)3.85982431
18DNA replication-independent nucleosome organization (GO:0034724)3.85982431
19replication fork processing (GO:0031297)3.83154352
20regulation of DNA endoreduplication (GO:0032875)3.80351966
21proteasome assembly (GO:0043248)3.78927618
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78907686
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77456998
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75792131
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75792131
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75792131
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74400091
28DNA replication-dependent nucleosome organization (GO:0034723)3.70795556
29DNA replication-dependent nucleosome assembly (GO:0006335)3.70795556
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.69744113
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.69744113
32DNA replication checkpoint (GO:0000076)3.66883050
33protein localization to kinetochore (GO:0034501)3.66709276
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.63707348
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63707348
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63322762
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.56467780
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55325849
39chaperone-mediated protein transport (GO:0072321)3.53985526
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51926426
41synapsis (GO:0007129)3.51844076
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47219291
43DNA catabolic process, exonucleolytic (GO:0000738)3.45694412
44negative regulation of ligase activity (GO:0051352)3.43875616
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43875616
46mitotic metaphase plate congression (GO:0007080)3.41723981
47mitotic sister chromatid segregation (GO:0000070)3.36480414
48pseudouridine synthesis (GO:0001522)3.35888022
49DNA unwinding involved in DNA replication (GO:0006268)3.34085451
50meiotic chromosome segregation (GO:0045132)3.32544693
51water-soluble vitamin biosynthetic process (GO:0042364)3.30981702
52attachment of spindle microtubules to kinetochore (GO:0008608)3.29717711
53regulation of cellular amino acid metabolic process (GO:0006521)3.25407205
54telomere maintenance via semi-conservative replication (GO:0032201)3.24701112
55histone-serine phosphorylation (GO:0035404)3.18197533
56telomere maintenance via recombination (GO:0000722)3.17850853
57mitotic recombination (GO:0006312)3.15955814
58recombinational repair (GO:0000725)3.15090305
59double-strand break repair via homologous recombination (GO:0000724)3.14205563
60DNA strand elongation involved in DNA replication (GO:0006271)3.10531685
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10476149
62spindle checkpoint (GO:0031577)3.09400438
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09220481
64transcription elongation from RNA polymerase I promoter (GO:0006362)3.06399861
65sister chromatid segregation (GO:0000819)3.06325364
66ribosomal small subunit assembly (GO:0000028)3.02577291
67ribosome assembly (GO:0042255)3.01643630
68ATP synthesis coupled proton transport (GO:0015986)2.99737152
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99737152
70positive regulation of ligase activity (GO:0051351)2.99629021
71metaphase plate congression (GO:0051310)2.99489258
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98115857
73termination of RNA polymerase I transcription (GO:0006363)2.97451942
74DNA strand elongation (GO:0022616)2.95762645
75DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93149492
76mitotic spindle checkpoint (GO:0071174)2.91471687
77termination of RNA polymerase III transcription (GO:0006386)2.90540803
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.90540803
79protein K6-linked ubiquitination (GO:0085020)2.87038784
80response to X-ray (GO:0010165)2.86340390
81male meiosis (GO:0007140)2.86134879
82purine nucleobase biosynthetic process (GO:0009113)2.85435013
83protein localization to chromosome, centromeric region (GO:0071459)2.85387073
84nucleobase biosynthetic process (GO:0046112)2.85149013
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84130150
86negative regulation of mitotic sister chromatid separation (GO:2000816)2.83995270
87negative regulation of sister chromatid segregation (GO:0033046)2.83995270
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83995270
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83995270
90negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83995270
91cytidine metabolic process (GO:0046087)2.83822620
92cytidine catabolic process (GO:0006216)2.83822620
93cytidine deamination (GO:0009972)2.83822620
94negative regulation of chromosome segregation (GO:0051985)2.83544230
95spliceosomal snRNP assembly (GO:0000387)2.82201685
96positive regulation of cell cycle arrest (GO:0071158)2.81958913
97protein neddylation (GO:0045116)2.81897843
98ventricular cardiac muscle cell development (GO:0055015)2.79666556
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79520268
100prenylation (GO:0097354)2.77646716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.44142927
2E2F7_22180533_ChIP-Seq_HELA_Human5.15808949
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18788157
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.14230245
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62023945
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.43388874
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.12085802
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.04811338
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02556645
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91785828
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89652876
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86003508
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79623479
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.79073386
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73029472
16ZNF274_21170338_ChIP-Seq_K562_Hela2.61372621
17ELK1_19687146_ChIP-ChIP_HELA_Human2.56113907
18VDR_23849224_ChIP-Seq_CD4+_Human2.48376674
19FOXP3_21729870_ChIP-Seq_TREG_Human2.44676452
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41768793
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.34844943
22VDR_22108803_ChIP-Seq_LS180_Human2.16840639
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09105120
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04501028
25MYC_18940864_ChIP-ChIP_HL60_Human2.00880398
26IGF1R_20145208_ChIP-Seq_DFB_Human2.00023068
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98425071
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94971553
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.92522628
30EWS_26573619_Chip-Seq_HEK293_Human1.84358641
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.82966659
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80932367
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77409661
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76547161
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74453185
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.73336033
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69411819
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.65870518
39AR_21909140_ChIP-Seq_LNCAP_Human1.65517076
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61365232
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60847672
42DCP1A_22483619_ChIP-Seq_HELA_Human1.59142242
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57198001
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55558657
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.55260012
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.54871758
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54813707
48FUS_26573619_Chip-Seq_HEK293_Human1.53736528
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53501912
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51450222
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50505183
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50165046
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47468553
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44877211
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43529026
56TTF2_22483619_ChIP-Seq_HELA_Human1.42513107
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42051720
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35936475
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35585454
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31768980
61GABP_19822575_ChIP-Seq_HepG2_Human1.28779876
62XRN2_22483619_ChIP-Seq_HELA_Human1.20247978
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18149253
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16363358
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14845509
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.14553845
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.11038577
68IRF1_19129219_ChIP-ChIP_H3396_Human1.10463684
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09142537
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08458363
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03086418
72P300_19829295_ChIP-Seq_ESCs_Human1.01488398
73EZH2_27294783_Chip-Seq_NPCs_Mouse0.95667288
74SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94949109
75CIITA_25753668_ChIP-Seq_RAJI_Human0.93654678
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91596958
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.90086528
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89081643
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88352962
80BCAT_22108803_ChIP-Seq_LS180_Human0.85735314
81TAF15_26573619_Chip-Seq_HEK293_Human0.84823865
82ELK1_22589737_ChIP-Seq_MCF10A_Human0.84000436
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83544607
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83459515
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82496841
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79853491
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78557569
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77135384
89ER_23166858_ChIP-Seq_MCF-7_Human0.77108057
90TP53_22573176_ChIP-Seq_HFKS_Human0.76953312
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75447800
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74615299
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74346346
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74084487
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73508968
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.73508968
97KDM5A_27292631_Chip-Seq_BREAST_Human0.72411839
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72385999
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71155127
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.70965704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication7.48894941
2MP0002102_abnormal_ear_morphology4.30313608
3MP0000569_abnormal_digit_pigmentation3.69875985
4MP0010094_abnormal_chromosome_stability3.38440926
5MP0008058_abnormal_DNA_repair3.21676253
6MP0003693_abnormal_embryo_hatching2.95449016
7MP0004957_abnormal_blastocyst_morpholog2.92496212
8MP0006292_abnormal_olfactory_placode2.89070035
9MP0003111_abnormal_nucleus_morphology2.81499478
10MP0003077_abnormal_cell_cycle2.64913984
11MP0009697_abnormal_copulation2.55250734
12MP0000372_irregular_coat_pigmentation2.54976751
13MP0003806_abnormal_nucleotide_metabolis2.47124931
14MP0009379_abnormal_foot_pigmentation2.22977276
15MP0002163_abnormal_gland_morphology2.05589289
16MP0003718_maternal_effect1.89399032
17MP0008877_abnormal_DNA_methylation1.82696036
18MP0002876_abnormal_thyroid_physiology1.80408890
19MP0006072_abnormal_retinal_apoptosis1.79941839
20MP0002938_white_spotting1.75340165
21MP0005671_abnormal_response_to1.72513288
22MP0005075_abnormal_melanosome_morpholog1.72304783
23MP0001873_stomach_inflammation1.71737970
24MP0008932_abnormal_embryonic_tissue1.68314688
25MP0004885_abnormal_endolymph1.60002738
26MP0002736_abnormal_nociception_after1.52014915
27MP0003878_abnormal_ear_physiology1.49895277
28MP0005377_hearing/vestibular/ear_phenot1.49895277
29MP0009333_abnormal_splenocyte_physiolog1.45808658
30MP0005083_abnormal_biliary_tract1.41793416
31MP0001835_abnormal_antigen_presentation1.36816627
32MP0006035_abnormal_mitochondrial_morpho1.35889713
33MP0003786_premature_aging1.34714873
34MP0003186_abnormal_redox_activity1.33738018
35MP0000685_abnormal_immune_system1.30910379
36MP0008007_abnormal_cellular_replicative1.30356586
37MP0002210_abnormal_sex_determination1.29790732
38MP0002095_abnormal_skin_pigmentation1.27217441
39MP0001529_abnormal_vocalization1.26967376
40MP0004145_abnormal_muscle_electrophysio1.26436407
41MP0010030_abnormal_orbit_morphology1.26100609
42MP0008872_abnormal_physiological_respon1.24002888
43MP0001929_abnormal_gametogenesis1.23685417
44MP0004147_increased_porphyrin_level1.23157295
45MP0002277_abnormal_respiratory_mucosa1.18898946
46MP0004133_heterotaxia1.12008542
47MP0010307_abnormal_tumor_latency1.11213421
48MP0003136_yellow_coat_color1.10284555
49MP0005174_abnormal_tail_pigmentation1.07884243
50MP0005379_endocrine/exocrine_gland_phen1.07545289
51MP0003646_muscle_fatigue1.06910223
52MP0001293_anophthalmia1.04094585
53MP0001905_abnormal_dopamine_level1.03060261
54MP0001968_abnormal_touch/_nociception1.02631502
55MP0006036_abnormal_mitochondrial_physio1.01963435
56MP0001119_abnormal_female_reproductive1.01676035
57MP0003252_abnormal_bile_duct0.98620262
58MP0001697_abnormal_embryo_size0.97844552
59MP0000653_abnormal_sex_gland0.97686631
60MP0000015_abnormal_ear_pigmentation0.95395577
61MP0001188_hyperpigmentation0.91711550
62MP0005266_abnormal_metabolism0.90792198
63MP0001145_abnormal_male_reproductive0.90706572
64MP0000350_abnormal_cell_proliferation0.90647178
65MP0002160_abnormal_reproductive_system0.89530987
66MP0001346_abnormal_lacrimal_gland0.88924240
67MP0002166_altered_tumor_susceptibility0.88343464
68MP0002751_abnormal_autonomic_nervous0.86308305
69MP0002006_tumorigenesis0.81391695
70MP0008875_abnormal_xenobiotic_pharmacok0.78083330
71MP0005253_abnormal_eye_physiology0.75122610
72MP0005084_abnormal_gallbladder_morpholo0.74909461
73MP0010368_abnormal_lymphatic_system0.74450562
74MP0005647_abnormal_sex_gland0.72391766
75MP0001286_abnormal_eye_development0.72384184
76MP0005389_reproductive_system_phenotype0.68871739
77MP0000631_abnormal_neuroendocrine_gland0.67936321
78MP0001348_abnormal_lacrimal_gland0.67065523
79MP0002019_abnormal_tumor_incidence0.66093959
80MP0000647_abnormal_sebaceous_gland0.65715402
81MP0000313_abnormal_cell_death0.64450876
82MP0002396_abnormal_hematopoietic_system0.63608495
83MP0001324_abnormal_eye_pigmentation0.62591248
84MP0005171_absent_coat_pigmentation0.62321930
85MP0003137_abnormal_impulse_conducting0.61950490
86MP0002148_abnormal_hypersensitivity_rea0.61919042
87MP0003698_abnormal_male_reproductive0.60182174
88MP0004197_abnormal_fetal_growth/weight/0.59114457
89MP0003941_abnormal_skin_development0.59072076
90MP0000358_abnormal_cell_content/0.58019850
91MP0002138_abnormal_hepatobiliary_system0.56764790
92MP0002234_abnormal_pharynx_morphology0.55698348
93MP0001177_atelectasis0.55394681
94MP0005085_abnormal_gallbladder_physiolo0.55102538
95MP0005408_hypopigmentation0.54805247
96MP0001730_embryonic_growth_arrest0.54556513
97MP0000371_diluted_coat_color0.53843803
98MP0003195_calcinosis0.52175780
99MP0004742_abnormal_vestibular_system0.50825098
100MP0003943_abnormal_hepatobiliary_system0.49360500

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)5.40431610
2Degeneration of anterior horn cells (HP:0002398)5.40431610
3Neoplasm of the adrenal cortex (HP:0100641)4.18035135
4Acute necrotizing encephalopathy (HP:0006965)3.99542860
5Acute encephalopathy (HP:0006846)3.90012455
6Increased hepatocellular lipid droplets (HP:0006565)3.55169098
7Increased CSF lactate (HP:0002490)3.50702738
8Mitochondrial inheritance (HP:0001427)3.38688160
9Abnormal mitochondria in muscle tissue (HP:0008316)3.35921214
10Progressive macrocephaly (HP:0004481)3.34991421
11Lipid accumulation in hepatocytes (HP:0006561)3.10909023
12Neoplasm of the adrenal gland (HP:0100631)3.05667145
13Progressive inability to walk (HP:0002505)2.98942592
14Abnormal lung lobation (HP:0002101)2.93242133
15Volvulus (HP:0002580)2.87660508
16Intestinal atresia (HP:0011100)2.84781497
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82338846
18Hypoplasia of the pons (HP:0012110)2.75434152
19Autoimmune hemolytic anemia (HP:0001890)2.74620773
20Increased serum lactate (HP:0002151)2.73497026
21Congenital, generalized hypertrichosis (HP:0004540)2.73458062
22Upper motor neuron abnormality (HP:0002127)2.69722232
23Abnormality of the ileum (HP:0001549)2.64787069
24Cerebral edema (HP:0002181)2.62890294
25Abnormality of the pons (HP:0007361)2.62126264
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.62125608
27Duodenal stenosis (HP:0100867)2.60189212
28Small intestinal stenosis (HP:0012848)2.60189212
29Meckel diverticulum (HP:0002245)2.56986654
30Hepatocellular necrosis (HP:0001404)2.56965900
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52524422
32Chromsome breakage (HP:0040012)2.52488560
33Renal Fanconi syndrome (HP:0001994)2.45602521
34Hypomagnesemia (HP:0002917)2.45320995
35Abnormality of the labia minora (HP:0012880)2.45054213
36Neoplasm of the colon (HP:0100273)2.44767437
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43157973
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.43020415
39Birth length less than 3rd percentile (HP:0003561)2.42264649
40Autoimmune thrombocytopenia (HP:0001973)2.40345458
41Abnormality of the duodenum (HP:0002246)2.39340904
42Increased IgM level (HP:0003496)2.33703642
43Abnormality of chromosome stability (HP:0003220)2.31772136
44Leukodystrophy (HP:0002415)2.31589344
45Amyotrophic lateral sclerosis (HP:0007354)2.31346761
46Impaired proprioception (HP:0010831)2.23425069
47Colon cancer (HP:0003003)2.21579512
48Limb hypertonia (HP:0002509)2.20946226
49Conjunctival telangiectasia (HP:0000524)2.19715257
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18558366
51Myelodysplasia (HP:0002863)2.17679928
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17256754
53Exertional dyspnea (HP:0002875)2.15705195
54Abnormality of DNA repair (HP:0003254)2.15679996
55Optic disc pallor (HP:0000543)2.15582180
56Abnormality of the preputium (HP:0100587)2.15068129
57Abnormality of serum amino acid levels (HP:0003112)2.13504416
58Lactic acidosis (HP:0003128)2.12950983
59Inability to walk (HP:0002540)2.11698705
60Hepatic necrosis (HP:0002605)2.11412477
61Abnormality of B cell number (HP:0010975)2.10185653
62Increased intramyocellular lipid droplets (HP:0012240)2.09751545
63Abnormality of magnesium homeostasis (HP:0004921)2.07294800
64Microvesicular hepatic steatosis (HP:0001414)2.03121456
65Abnormality of the lower motor neuron (HP:0002366)2.03050784
66Pancytopenia (HP:0001876)2.02411255
67Nephroblastoma (Wilms tumor) (HP:0002667)2.02406886
68Clubbing of toes (HP:0100760)2.01834143
69Abnormal hair whorl (HP:0010721)2.01135332
70Respiratory difficulties (HP:0002880)2.00989032
71Ependymoma (HP:0002888)2.00078387
72Embryonal renal neoplasm (HP:0011794)1.95603478
73Sloping forehead (HP:0000340)1.94836369
74Retinal dysplasia (HP:0007973)1.93639885
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.91970901
76Gaze-evoked nystagmus (HP:0000640)1.90170344
77Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90098871
78Increased nuchal translucency (HP:0010880)1.89803970
79Septo-optic dysplasia (HP:0100842)1.89340312
80Attenuation of retinal blood vessels (HP:0007843)1.88101609
81Glioma (HP:0009733)1.87655422
82Reticulocytopenia (HP:0001896)1.86714619
83Small hand (HP:0200055)1.86646753
84Decreased central vision (HP:0007663)1.85293817
85Asplenia (HP:0001746)1.85073208
86B lymphocytopenia (HP:0010976)1.85071127
87Abnormal number of incisors (HP:0011064)1.84965671
88Exercise intolerance (HP:0003546)1.84945664
89Abolished electroretinogram (ERG) (HP:0000550)1.84109370
90Gastrointestinal atresia (HP:0002589)1.83018948
91Absent thumb (HP:0009777)1.82996802
923-Methylglutaconic aciduria (HP:0003535)1.81011062
93Melanoma (HP:0002861)1.80588365
94Pancreatic cysts (HP:0001737)1.80089332
95Pancreatic fibrosis (HP:0100732)1.78981157
96Abnormality of the carotid arteries (HP:0005344)1.76921272
97Abnormal number of erythroid precursors (HP:0012131)1.75603451
98Triphalangeal thumb (HP:0001199)1.73365820
99Abnormality of T cell physiology (HP:0011840)1.71391696
100Supernumerary spleens (HP:0009799)1.70792545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.87037288
2BUB13.74763523
3WEE13.26894752
4VRK22.98083293
5TAF12.95087663
6VRK12.84888880
7TLK12.83736876
8EIF2AK32.79364780
9EIF2AK12.52557134
10TSSK62.50626562
11TRIM282.48804294
12PLK32.34939606
13MST42.34458892
14TTK2.29372973
15CDC72.17136883
16PINK12.14480875
17NEK12.12867210
18BCR2.00477544
19WNK41.94709342
20PNCK1.93843680
21PLK11.56327999
22BMPR1B1.55855560
23ATR1.49758876
24PLK41.48478380
25EIF2AK21.43661721
26WNK31.43250204
27BRSK21.39760534
28FRK1.39370296
29MKNK21.37505911
30KDR1.32140627
31STK38L1.26042579
32ERBB41.21739720
33TNIK1.13469009
34PDK21.07887744
35PLK21.06028348
36CDK41.05678536
37PASK1.03570799
38AURKB1.03025445
39NUAK11.02356039
40STK31.02342927
41OXSR11.00071145
42STK390.99419240
43ACVR1B0.98739324
44ADRBK20.97582058
45CHEK20.95210290
46TYRO30.92076548
47MKNK10.91972721
48PBK0.90748336
49GRK10.90510399
50DAPK30.89345349
51NME10.88892527
52MAPKAPK50.85608390
53CDK60.80293904
54SRPK10.79995340
55AURKA0.75101772
56ATM0.74638009
57BRSK10.69530877
58STK40.67063367
59CSNK1G10.64710787
60CSNK1G30.63753739
61KIT0.63511021
62PAK30.63493252
63CSNK1G20.61873312
64TXK0.58363172
65GRK50.56523985
66PIM10.55177891
67CDK190.54879705
68CHEK10.53947518
69DYRK20.53460449
70TGFBR10.52613733
71NME20.50432480
72CDK70.49869263
73PRKCI0.47867604
74MST1R0.47733713
75STK240.45894713
76STK160.45410820
77ERBB30.45278433
78CDK80.43328727
79CSNK2A10.42324572
80DAPK10.42212034
81PRKCG0.42168208
82INSRR0.40693575
83CSNK2A20.39690369
84MAPKAPK20.39198707
85NEK60.38571538
86SIK30.36373581
87SMG10.33275247
88TGFBR20.31287354
89PRKDC0.29206560
90RPS6KA50.28856462
91MAP3K120.26889646
92MELK0.25708731
93RPS6KA40.25357915
94MAP2K60.24943148
95CSNK1A10.24676972
96BMPR20.24523523
97FER0.24309295
98RPS6KB10.23933766
99FGFR10.23602628
100MATK0.23365631

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76286958
2Mismatch repair_Homo sapiens_hsa034303.26163354
3Protein export_Homo sapiens_hsa030603.23052455
4DNA replication_Homo sapiens_hsa030302.85990502
5Non-homologous end-joining_Homo sapiens_hsa034502.82144004
6Ribosome_Homo sapiens_hsa030102.70590290
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65239020
8Homologous recombination_Homo sapiens_hsa034402.62701337
9RNA polymerase_Homo sapiens_hsa030202.55839329
10Asthma_Homo sapiens_hsa053102.45698466
11Fanconi anemia pathway_Homo sapiens_hsa034602.34084964
12Oxidative phosphorylation_Homo sapiens_hsa001902.28289406
13Parkinsons disease_Homo sapiens_hsa050122.15111862
14Basal transcription factors_Homo sapiens_hsa030222.09609074
15Nucleotide excision repair_Homo sapiens_hsa034202.08233341
16Allograft rejection_Homo sapiens_hsa053302.07673147
17One carbon pool by folate_Homo sapiens_hsa006702.01211733
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93807482
19Cell cycle_Homo sapiens_hsa041101.84857136
20Autoimmune thyroid disease_Homo sapiens_hsa053201.82007731
21Type I diabetes mellitus_Homo sapiens_hsa049401.75805063
22Graft-versus-host disease_Homo sapiens_hsa053321.74990216
23RNA degradation_Homo sapiens_hsa030181.73593374
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71815887
25Propanoate metabolism_Homo sapiens_hsa006401.68414595
26Vitamin B6 metabolism_Homo sapiens_hsa007501.62249380
27Base excision repair_Homo sapiens_hsa034101.57848030
28RNA transport_Homo sapiens_hsa030131.49079491
29Huntingtons disease_Homo sapiens_hsa050161.48214924
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.47019276
31Pyrimidine metabolism_Homo sapiens_hsa002401.43447632
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.42196956
33Systemic lupus erythematosus_Homo sapiens_hsa053221.42177930
34Spliceosome_Homo sapiens_hsa030401.33804749
35p53 signaling pathway_Homo sapiens_hsa041151.27598007
36Pyruvate metabolism_Homo sapiens_hsa006201.17320366
37Purine metabolism_Homo sapiens_hsa002301.16696748
38Alzheimers disease_Homo sapiens_hsa050101.16501165
39Antigen processing and presentation_Homo sapiens_hsa046121.15584394
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98609015
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97907944
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97515485
43Folate biosynthesis_Homo sapiens_hsa007900.93902408
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87561013
45Fatty acid elongation_Homo sapiens_hsa000620.84227933
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84087382
47Steroid biosynthesis_Homo sapiens_hsa001000.83137787
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82578049
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82418622
50Phototransduction_Homo sapiens_hsa047440.82355111
51Rheumatoid arthritis_Homo sapiens_hsa053230.79575998
52Sulfur relay system_Homo sapiens_hsa041220.78043561
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76533442
54Primary immunodeficiency_Homo sapiens_hsa053400.76113985
55Oocyte meiosis_Homo sapiens_hsa041140.75826310
56Epstein-Barr virus infection_Homo sapiens_hsa051690.70433932
57Sulfur metabolism_Homo sapiens_hsa009200.68029809
58Regulation of autophagy_Homo sapiens_hsa041400.66961852
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63386629
60Hematopoietic cell lineage_Homo sapiens_hsa046400.61813235
61Caffeine metabolism_Homo sapiens_hsa002320.61531516
62Glutathione metabolism_Homo sapiens_hsa004800.60058817
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58659022
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58363093
65Peroxisome_Homo sapiens_hsa041460.55984397
66Cardiac muscle contraction_Homo sapiens_hsa042600.54792080
67Viral myocarditis_Homo sapiens_hsa054160.54647149
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54139914
69Selenocompound metabolism_Homo sapiens_hsa004500.53658215
70Metabolic pathways_Homo sapiens_hsa011000.50486552
71Alcoholism_Homo sapiens_hsa050340.49448579
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48865258
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48272375
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47000983
75Butanoate metabolism_Homo sapiens_hsa006500.46594786
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44141430
77Tryptophan metabolism_Homo sapiens_hsa003800.43921613
78Herpes simplex infection_Homo sapiens_hsa051680.42859837
79Linoleic acid metabolism_Homo sapiens_hsa005910.42282700
80Tyrosine metabolism_Homo sapiens_hsa003500.40863560
81Nitrogen metabolism_Homo sapiens_hsa009100.40537516
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40213844
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39388313
84mRNA surveillance pathway_Homo sapiens_hsa030150.37875415
85beta-Alanine metabolism_Homo sapiens_hsa004100.33224181
86N-Glycan biosynthesis_Homo sapiens_hsa005100.31979506
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31908901
88Carbon metabolism_Homo sapiens_hsa012000.26345266
89TGF-beta signaling pathway_Homo sapiens_hsa043500.24326488
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.22720901
91HTLV-I infection_Homo sapiens_hsa051660.21881229
92Fat digestion and absorption_Homo sapiens_hsa049750.20762564
93Olfactory transduction_Homo sapiens_hsa047400.20088305
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19196778
95Staphylococcus aureus infection_Homo sapiens_hsa051500.19169747
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.18751817
97Collecting duct acid secretion_Homo sapiens_hsa049660.16996039
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14012477
99Ether lipid metabolism_Homo sapiens_hsa005650.13894093
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13546283

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