RPSAP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.71017055
2epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.04991987
3viral transcription (GO:0019083)5.04473345
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.91898883
5mitochondrial respiratory chain complex I assembly (GO:0032981)4.91898883
6NADH dehydrogenase complex assembly (GO:0010257)4.91898883
7translational termination (GO:0006415)4.80796723
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66926893
9sequestering of actin monomers (GO:0042989)4.50952684
10translational elongation (GO:0006414)4.48599610
11protein complex biogenesis (GO:0070271)4.47240636
12ATP synthesis coupled proton transport (GO:0015986)4.46367265
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46367265
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40183154
15cotranslational protein targeting to membrane (GO:0006613)4.36734986
16protein targeting to ER (GO:0045047)4.31516406
17platelet dense granule organization (GO:0060155)4.30250315
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09059336
19protein localization to endoplasmic reticulum (GO:0070972)4.03022967
20mitochondrial respiratory chain complex assembly (GO:0033108)4.02310579
21behavioral response to nicotine (GO:0035095)3.95632160
22DNA deamination (GO:0045006)3.80358975
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.76680952
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75841708
25cellular protein complex disassembly (GO:0043624)3.64890697
26mitochondrial calcium ion transport (GO:0006851)3.63127995
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62985142
28translational initiation (GO:0006413)3.60836956
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58510880
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58510880
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57502247
32viral life cycle (GO:0019058)3.54363771
33ribosomal small subunit biogenesis (GO:0042274)3.52066532
34protein K6-linked ubiquitination (GO:0085020)3.48446991
35respiratory electron transport chain (GO:0022904)3.45966232
36maturation of 5.8S rRNA (GO:0000460)3.45950124
37protein-cofactor linkage (GO:0018065)3.39008557
38GMP metabolic process (GO:0046037)3.38128599
39alternative mRNA splicing, via spliceosome (GO:0000380)3.36326485
40electron transport chain (GO:0022900)3.35665038
41chromatin remodeling at centromere (GO:0031055)3.33915778
42inner mitochondrial membrane organization (GO:0007007)3.30404050
43mitochondrial RNA metabolic process (GO:0000959)3.29412697
44folic acid-containing compound biosynthetic process (GO:0009396)3.28753047
45regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.26493504
46cartilage morphogenesis (GO:0060536)3.25619683
47CENP-A containing nucleosome assembly (GO:0034080)3.22710572
48pseudouridine synthesis (GO:0001522)3.20239180
49protein neddylation (GO:0045116)3.19419645
50purine nucleotide salvage (GO:0032261)3.12397351
51negative regulation of transcription regulatory region DNA binding (GO:2000678)3.11864606
52adenosine metabolic process (GO:0046085)3.08632239
53translation (GO:0006412)3.08113015
54maturation of SSU-rRNA (GO:0030490)3.01212875
55respiratory chain complex IV assembly (GO:0008535)2.98877567
56transcription from mitochondrial promoter (GO:0006390)2.94789310
57protein complex disassembly (GO:0043241)2.94561757
58cysteine metabolic process (GO:0006534)2.93809474
59cellular component biogenesis (GO:0044085)2.92769812
60cellular ketone body metabolic process (GO:0046950)2.91803762
61metallo-sulfur cluster assembly (GO:0031163)2.89167274
62iron-sulfur cluster assembly (GO:0016226)2.89167274
63positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.88024506
64forebrain morphogenesis (GO:0048853)2.87493415
65rRNA processing (GO:0006364)2.86322163
66sulfur amino acid catabolic process (GO:0000098)2.85951891
67macromolecular complex disassembly (GO:0032984)2.83138380
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82630634
69peptidyl-histidine modification (GO:0018202)2.82081832
70ncRNA 3-end processing (GO:0043628)2.81643184
71tRNA processing (GO:0008033)2.76018499
72hydrogen ion transmembrane transport (GO:1902600)2.74715657
73nuclear-transcribed mRNA catabolic process (GO:0000956)2.74261070
74protein targeting to membrane (GO:0006612)2.72704896
75rRNA metabolic process (GO:0016072)2.72538428
76cytochrome complex assembly (GO:0017004)2.72251775
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67131914
78mannosylation (GO:0097502)2.65793507
79cellular protein complex localization (GO:0034629)2.64987768
80cochlea development (GO:0090102)2.63677235
81cullin deneddylation (GO:0010388)2.63485772
82negative regulation of telomere maintenance (GO:0032205)2.62326614
83mRNA catabolic process (GO:0006402)2.62169652
84negative regulation of epidermal cell differentiation (GO:0045605)2.61179289
85bone trabecula formation (GO:0060346)2.58469295
86positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.58365748
87ribonucleoprotein complex biogenesis (GO:0022613)2.57619100
88purine-containing compound salvage (GO:0043101)2.56973169
89ATP biosynthetic process (GO:0006754)2.55043672
90tRNA modification (GO:0006400)2.55020589
91pteridine-containing compound biosynthetic process (GO:0042559)2.54616718
92establishment of protein localization to mitochondrion (GO:0072655)2.54588128
93T cell migration (GO:0072678)2.54313986
94ribosomal large subunit biogenesis (GO:0042273)2.53999453
95formation of translation preinitiation complex (GO:0001731)2.53342093
96axoneme assembly (GO:0035082)2.53070048
97purine nucleobase biosynthetic process (GO:0009113)2.52901926
98purine nucleoside triphosphate biosynthetic process (GO:0009145)2.52891297
99ketone body metabolic process (GO:1902224)2.51906551
100positive regulation of meiosis (GO:0045836)2.51053246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.31392106
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00242434
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.36707642
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35228406
5EZH2_22144423_ChIP-Seq_EOC_Human3.21723516
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10600888
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06662869
8VDR_22108803_ChIP-Seq_LS180_Human2.80896747
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.72992510
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71771483
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70709111
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.63472599
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54592981
14ELK1_19687146_ChIP-ChIP_HELA_Human2.53885121
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53641926
16VDR_23849224_ChIP-Seq_CD4+_Human2.41301220
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37496893
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.33435885
19IGF1R_20145208_ChIP-Seq_DFB_Human2.15946643
20E2F7_22180533_ChIP-Seq_HELA_Human2.15127271
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07676953
22FOXP3_21729870_ChIP-Seq_TREG_Human2.05204131
23EWS_26573619_Chip-Seq_HEK293_Human2.00064033
24TTF2_22483619_ChIP-Seq_HELA_Human1.96090375
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95296161
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95106123
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.94346606
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85358101
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83117100
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.75815679
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72290748
32FUS_26573619_Chip-Seq_HEK293_Human1.71595152
33TP53_22573176_ChIP-Seq_HFKS_Human1.69107459
34XRN2_22483619_ChIP-Seq_HELA_Human1.61169297
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59114245
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58121485
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57542918
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.54642520
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48399342
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48212575
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47674302
42CIITA_25753668_ChIP-Seq_RAJI_Human1.47671303
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46170023
44MYC_18940864_ChIP-ChIP_HL60_Human1.45630742
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44686340
46DCP1A_22483619_ChIP-Seq_HELA_Human1.44521751
47ZNF274_21170338_ChIP-Seq_K562_Hela1.41191612
48HTT_18923047_ChIP-ChIP_STHdh_Human1.39560555
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39452490
50NCOR_22424771_ChIP-Seq_293T_Human1.36817641
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36426060
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30056879
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28111019
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24873162
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.24440994
56GABP_19822575_ChIP-Seq_HepG2_Human1.20428017
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20343957
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20036960
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18949862
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18412895
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.15613702
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15097459
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14447590
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14129677
65ER_23166858_ChIP-Seq_MCF-7_Human1.12694914
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09446941
67P300_19829295_ChIP-Seq_ESCs_Human1.08927681
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08836223
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08284011
70RNF2_27304074_Chip-Seq_NSC_Mouse1.08069489
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05867560
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05587293
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05276285
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04624200
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.04305435
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03984598
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03130875
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02172653
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.01879363
80RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99146357
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.98640087
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98640087
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98517406
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97116406
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95868186
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95473722
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94274692
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93529028
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93310239
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92063933
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89937022
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.86865781
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86674933
94PHF8_20622853_ChIP-Seq_HELA_Human0.86287355
95TAF15_26573619_Chip-Seq_HEK293_Human0.86000344
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83281417
97TAF2_19829295_ChIP-Seq_ESCs_Human0.83206507
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82409012
99NANOG_20526341_ChIP-Seq_ESCs_Human0.81947460
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80640275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence2.78085256
2MP0003283_abnormal_digestive_organ2.77885311
3MP0001764_abnormal_homeostasis2.62063360
4MP0006292_abnormal_olfactory_placode2.52665651
5MP0005084_abnormal_gallbladder_morpholo2.49116991
6MP0002938_white_spotting2.47954225
7MP0002009_preneoplasia2.37347892
8MP0005646_abnormal_pituitary_gland2.35383699
9MP0003315_abnormal_perineum_morphology2.30618952
10MP0009379_abnormal_foot_pigmentation2.20147651
11MP0005671_abnormal_response_to2.06746468
12MP0002653_abnormal_ependyma_morphology2.00958971
13MP0002928_abnormal_bile_duct1.97320578
14MP0003880_abnormal_central_pattern1.91377279
15MP0004145_abnormal_muscle_electrophysio1.85699293
16MP0003786_premature_aging1.85115131
17MP0002006_tumorigenesis1.82095308
18MP0002102_abnormal_ear_morphology1.77345645
19MP0005253_abnormal_eye_physiology1.71650658
20MP0003693_abnormal_embryo_hatching1.70657915
21MP0005551_abnormal_eye_electrophysiolog1.69892381
22MP0000049_abnormal_middle_ear1.65729235
23MP0001188_hyperpigmentation1.64198819
24MP0002163_abnormal_gland_morphology1.60803725
25MP0002234_abnormal_pharynx_morphology1.58080411
26MP0002138_abnormal_hepatobiliary_system1.54780492
27MP0001919_abnormal_reproductive_system1.53740410
28MP0000566_synostosis1.53261066
29MP0003937_abnormal_limbs/digits/tail_de1.46810299
30MP0003646_muscle_fatigue1.46517572
31MP0004885_abnormal_endolymph1.45266067
32MP0002166_altered_tumor_susceptibility1.45070109
33MP0009053_abnormal_anal_canal1.43942280
34MP0005389_reproductive_system_phenotype1.41584840
35MP0003942_abnormal_urinary_system1.41022593
36MP0002160_abnormal_reproductive_system1.37826534
37MP0001661_extended_life_span1.36197168
38MP0005379_endocrine/exocrine_gland_phen1.34161749
39MP0001986_abnormal_taste_sensitivity1.33516676
40MP0005423_abnormal_somatic_nervous1.33043471
41MP0005187_abnormal_penis_morphology1.32667515
42MP0001293_anophthalmia1.31847416
43MP0002282_abnormal_trachea_morphology1.30587055
44MP0000647_abnormal_sebaceous_gland1.25929466
45MP0004957_abnormal_blastocyst_morpholog1.25819121
46MP0000631_abnormal_neuroendocrine_gland1.25307981
47MP0009250_abnormal_appendicular_skeleto1.23379307
48MP0002638_abnormal_pupillary_reflex1.20620868
49MP0001286_abnormal_eye_development1.19510630
50MP0006072_abnormal_retinal_apoptosis1.19415202
51MP0003011_delayed_dark_adaptation1.16978543
52MP0001529_abnormal_vocalization1.15479912
53MP0005391_vision/eye_phenotype1.12828520
54MP0003186_abnormal_redox_activity1.11371442
55MP0002210_abnormal_sex_determination1.10140912
56MP0001968_abnormal_touch/_nociception1.09211985
57MP0001873_stomach_inflammation1.07584024
58MP0004142_abnormal_muscle_tone1.06861322
59MP0004134_abnormal_chest_morphology1.04396495
60MP0005645_abnormal_hypothalamus_physiol1.04215832
61MP0002736_abnormal_nociception_after1.03849068
62MP0002837_dystrophic_cardiac_calcinosis1.03385967
63MP0003183_abnormal_peptide_metabolism1.03116191
64MP0008872_abnormal_physiological_respon1.00922798
65MP0000653_abnormal_sex_gland1.00677379
66MP0001119_abnormal_female_reproductive1.00036733
67MP0003111_abnormal_nucleus_morphology0.98170082
68MP0003567_abnormal_fetal_cardiomyocyte0.96439805
69MP0001348_abnormal_lacrimal_gland0.94975671
70MP0003806_abnormal_nucleotide_metabolis0.93650623
71MP0008961_abnormal_basal_metabolism0.93381879
72MP0003936_abnormal_reproductive_system0.92427033
73MP0000026_abnormal_inner_ear0.91346283
74MP0004147_increased_porphyrin_level0.90984766
75MP0002095_abnormal_skin_pigmentation0.90800161
76MP0001944_abnormal_pancreas_morphology0.89693836
77MP0000613_abnormal_salivary_gland0.88767133
78MP0003698_abnormal_male_reproductive0.88600195
79MP0008877_abnormal_DNA_methylation0.87909499
80MP0002249_abnormal_larynx_morphology0.86253103
81MP0002693_abnormal_pancreas_physiology0.85897017
82MP0001145_abnormal_male_reproductive0.85891541
83MP0009333_abnormal_splenocyte_physiolog0.84324169
84MP0000537_abnormal_urethra_morphology0.83881254
85MP0005195_abnormal_posterior_eye0.83536237
86MP0004742_abnormal_vestibular_system0.82315226
87MP0010030_abnormal_orbit_morphology0.81137512
88MP0002184_abnormal_innervation0.80177375
89MP0001929_abnormal_gametogenesis0.78315175
90MP0002752_abnormal_somatic_nervous0.77223169
91MP0000778_abnormal_nervous_system0.76994702
92MP0003755_abnormal_palate_morphology0.76505905
93MP0003943_abnormal_hepatobiliary_system0.75708214
94MP0000678_abnormal_parathyroid_gland0.74555827
95MP0000372_irregular_coat_pigmentation0.73136133
96MP0002127_abnormal_cardiovascular_syste0.70727393
97MP0003077_abnormal_cell_cycle0.70374486
98MP0004133_heterotaxia0.70106286
99MP0001270_distended_abdomen0.69696069
100MP0001486_abnormal_startle_reflex0.68627243

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.56100008
2Hyperalaninemia (HP:0003348)4.56100008
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.56100008
4Aplastic anemia (HP:0001915)3.83245417
5Acute necrotizing encephalopathy (HP:0006965)3.75291058
6Mitochondrial inheritance (HP:0001427)3.57056485
73-Methylglutaconic aciduria (HP:0003535)3.56671734
8True hermaphroditism (HP:0010459)3.45320840
9Concave nail (HP:0001598)3.33921338
10Increased CSF lactate (HP:0002490)3.31772690
11Increased hepatocellular lipid droplets (HP:0006565)3.28020827
12Abnormal mitochondria in muscle tissue (HP:0008316)3.23372609
13Progressive macrocephaly (HP:0004481)3.17844253
14Pancreatic cysts (HP:0001737)3.14090158
15Cerebral edema (HP:0002181)3.11327715
16Reticulocytopenia (HP:0001896)3.02886293
17Acute encephalopathy (HP:0006846)3.01760266
18Hepatocellular necrosis (HP:0001404)2.98111843
19Pendular nystagmus (HP:0012043)2.93266261
20Pancreatic fibrosis (HP:0100732)2.92064109
21Constricted visual fields (HP:0001133)2.91139351
22Optic disc pallor (HP:0000543)2.82263592
23Lipid accumulation in hepatocytes (HP:0006561)2.81993338
24Abnormality of cells of the erythroid lineage (HP:0012130)2.79324870
25High anterior hairline (HP:0009890)2.76897265
26Increased serum lactate (HP:0002151)2.74684653
27Abnormal number of erythroid precursors (HP:0012131)2.73718383
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72032904
29Renal Fanconi syndrome (HP:0001994)2.59430153
30Congenital stationary night blindness (HP:0007642)2.59006402
31Hepatic necrosis (HP:0002605)2.51792719
32Abnormal lung lobation (HP:0002101)2.49033386
33Amyotrophic lateral sclerosis (HP:0007354)2.47427394
34Lactic acidosis (HP:0003128)2.46976134
35Macrocytic anemia (HP:0001972)2.46369126
36Abnormal rod and cone electroretinograms (HP:0008323)2.45599421
37Attenuation of retinal blood vessels (HP:0007843)2.42995844
38Pigmentary retinal degeneration (HP:0001146)2.42262984
39Abnormality of the fetal cardiovascular system (HP:0010948)2.41852666
40Abnormal umbilical cord blood vessels (HP:0011403)2.41852666
41Single umbilical artery (HP:0001195)2.41852666
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38356415
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.37988339
44Abnormality of midbrain morphology (HP:0002418)2.36571855
45Molar tooth sign on MRI (HP:0002419)2.36571855
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36090174
47Abnormality of the 4th metacarpal (HP:0010012)2.35122983
48Limb hypertonia (HP:0002509)2.34456442
49Abnormality of the phalanges of the 5th finger (HP:0004213)2.30191797
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.30136526
51Asplenia (HP:0001746)2.29368303
52Short middle phalanx of the 5th finger (HP:0004220)2.29065794
53Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.28493624
54Hypoplasia of the uterus (HP:0000013)2.25494797
55Sclerocornea (HP:0000647)2.24903794
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21298815
57Abnormality of serum amino acid levels (HP:0003112)2.20569445
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19631389
59Short 4th metacarpal (HP:0010044)2.19631389
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16619491
61Confusion (HP:0001289)2.15901867
62Aplasia/hypoplasia of the uterus (HP:0008684)2.14370857
63Supernumerary spleens (HP:0009799)2.13012444
64Anencephaly (HP:0002323)2.06767567
65Triphalangeal thumb (HP:0001199)2.06020215
66Increased intramyocellular lipid droplets (HP:0012240)1.98828878
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98788595
68Postaxial foot polydactyly (HP:0001830)1.97921369
69Oral leukoplakia (HP:0002745)1.96708773
70Absent thumb (HP:0009777)1.96531953
71Pallor (HP:0000980)1.90766291
72Pheochromocytoma (HP:0002666)1.87113119
73Chronic hepatic failure (HP:0100626)1.85144581
74Abnormality of homocysteine metabolism (HP:0010919)1.84109639
75Homocystinuria (HP:0002156)1.84109639
76Lethargy (HP:0001254)1.82949923
77Abnormality of the parietal bone (HP:0002696)1.80229200
78Oligodactyly (HP:0012165)1.80185517
79Male pseudohermaphroditism (HP:0000037)1.79447370
80Tetany (HP:0001281)1.73983170
81Decreased central vision (HP:0007663)1.73560727
82Cerebellar dysplasia (HP:0007033)1.72988974
83Short 5th finger (HP:0009237)1.70765651
84Rib fusion (HP:0000902)1.69381583
85Gonadal dysgenesis (HP:0000133)1.69222739
86Hypomagnesemia (HP:0002917)1.69016330
87Horseshoe kidney (HP:0000085)1.68686698
88Hyperphosphaturia (HP:0003109)1.68340428
89Respiratory difficulties (HP:0002880)1.67378216
90Abolished electroretinogram (ERG) (HP:0000550)1.67341077
91Median cleft lip (HP:0000161)1.67319189
92Respiratory failure (HP:0002878)1.66136978
93Birth length less than 3rd percentile (HP:0003561)1.65357894
94Keratoconus (HP:0000563)1.65002221
95Increased corneal curvature (HP:0100692)1.65002221
96Abnormality of the labia minora (HP:0012880)1.62882794
97Abnormality of the umbilical cord (HP:0010881)1.62267920
98Pancytopenia (HP:0001876)1.61847652
99Abnormality of magnesium homeostasis (HP:0004921)1.61386698
100Exertional dyspnea (HP:0002875)1.60796389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.63918451
2BUB13.42435766
3NUAK13.00842206
4CDK192.90528823
5EIF2AK32.87972923
6EPHB22.60620659
7NLK2.58909228
8STK162.49428793
9BCKDK2.40524292
10WEE12.23885792
11PRKD32.15244569
12PASK2.02200144
13TXK1.98405714
14VRK11.92660146
15MUSK1.92626191
16TESK21.90740413
17ZAK1.84561635
18MAP4K21.77760562
19MAP4K11.58313863
20KDR1.54704858
21TLK11.53098591
22WNK31.52471010
23MAP3K121.52071023
24MAP3K111.49899727
25TAF11.48437976
26CDK31.47452881
27MAPK131.47101529
28ADRBK21.40431021
29GRK11.30381346
30NEK21.25740344
31RPS6KA41.22089857
32PLK41.21069564
33PNCK1.15676939
34PINK11.07894791
35BMPR1B1.05980273
36MAP3K101.01701313
37STK31.01586146
38CSNK1G10.99443892
39CLK10.99286656
40CDC70.98266836
41SGK20.96054349
42TGFBR10.93686002
43NEK10.91515694
44WNK40.87044465
45SYK0.86774533
46EIF2AK20.81462610
47TNK20.81362341
48CHEK20.81188839
49PIK3CG0.79372920
50PRKCH0.77064263
51IRAK40.76534776
52ITK0.76513355
53PLK30.74031462
54STK390.71570052
55MAP3K50.71527439
56SGK2230.66244303
57SGK4940.66244303
58CCNB10.61643177
59DYRK30.61484700
60DYRK20.61465589
61CDK80.60474279
62PRKCG0.59045107
63CDK90.57186902
64EIF2AK10.56001649
65FRK0.55773902
66ATR0.55017835
67CDK40.54536894
68MAPK70.52739035
69EPHA40.51105735
70PIM20.50247373
71MARK10.50137487
72PLK10.49790079
73PRKCQ0.48145087
74AURKA0.47483323
75CAMK10.47225722
76NEK90.46442838
77TNIK0.46095040
78UHMK10.43817626
79MAP2K70.43100731
80BTK0.42906473
81SRPK10.41791765
82STK38L0.41618626
83NTRK20.41126766
84CSNK2A10.40948151
85CDK70.39902864
86YES10.36713429
87IKBKE0.35292936
88AURKB0.34933602
89ADRBK10.34391215
90BRSK20.32220728
91BLK0.31057208
92MAPKAPK50.28922220
93CSNK1A10.26643475
94PAK10.26591496
95MAP2K40.26463408
96CSNK2A20.26266289
97CAMK2D0.25452754
98SGK30.22945726
99RPS6KB10.22578974
100PKN10.22197218

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.73766732
2Oxidative phosphorylation_Homo sapiens_hsa001903.91663893
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43282026
4Parkinsons disease_Homo sapiens_hsa050123.08769864
5Proteasome_Homo sapiens_hsa030502.79185751
6One carbon pool by folate_Homo sapiens_hsa006702.75216961
7Protein export_Homo sapiens_hsa030602.54909918
8DNA replication_Homo sapiens_hsa030302.44607985
9Sulfur relay system_Homo sapiens_hsa041222.26277049
10Huntingtons disease_Homo sapiens_hsa050162.17565189
11Mismatch repair_Homo sapiens_hsa034302.04832253
12RNA degradation_Homo sapiens_hsa030182.02505340
13RNA polymerase_Homo sapiens_hsa030201.95690757
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94331021
15Primary immunodeficiency_Homo sapiens_hsa053401.93812881
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93473302
17Alzheimers disease_Homo sapiens_hsa050101.92116375
18Homologous recombination_Homo sapiens_hsa034401.84553431
19Nucleotide excision repair_Homo sapiens_hsa034201.80284669
20Phototransduction_Homo sapiens_hsa047441.74150094
21Butanoate metabolism_Homo sapiens_hsa006501.67175870
22Spliceosome_Homo sapiens_hsa030401.65928722
23Basal transcription factors_Homo sapiens_hsa030221.64553251
24Folate biosynthesis_Homo sapiens_hsa007901.60775314
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59164170
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.51657067
27Cardiac muscle contraction_Homo sapiens_hsa042601.44547958
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42567847
29Steroid biosynthesis_Homo sapiens_hsa001001.34816118
30Base excision repair_Homo sapiens_hsa034101.30683108
31Pyrimidine metabolism_Homo sapiens_hsa002401.26669763
32Caffeine metabolism_Homo sapiens_hsa002321.26367063
33Nitrogen metabolism_Homo sapiens_hsa009101.24343065
34Hedgehog signaling pathway_Homo sapiens_hsa043401.22572023
35Purine metabolism_Homo sapiens_hsa002301.16875276
36Olfactory transduction_Homo sapiens_hsa047401.10771528
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09483717
38RNA transport_Homo sapiens_hsa030131.09014221
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.00523509
40Linoleic acid metabolism_Homo sapiens_hsa005911.00399781
41Fanconi anemia pathway_Homo sapiens_hsa034600.99498277
42Basal cell carcinoma_Homo sapiens_hsa052170.98593713
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98189282
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97267189
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96121732
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96064746
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90191212
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89201064
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87416599
50Nicotine addiction_Homo sapiens_hsa050330.84936005
51Propanoate metabolism_Homo sapiens_hsa006400.82086805
52Cell cycle_Homo sapiens_hsa041100.80498801
53T cell receptor signaling pathway_Homo sapiens_hsa046600.78997145
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78979560
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75340502
56Sulfur metabolism_Homo sapiens_hsa009200.74850461
57Vitamin digestion and absorption_Homo sapiens_hsa049770.74711833
58Antigen processing and presentation_Homo sapiens_hsa046120.70456315
59Collecting duct acid secretion_Homo sapiens_hsa049660.60575705
60Selenocompound metabolism_Homo sapiens_hsa004500.60244155
61Metabolic pathways_Homo sapiens_hsa011000.59197367
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.56180645
63Taste transduction_Homo sapiens_hsa047420.55490590
64Peroxisome_Homo sapiens_hsa041460.54810998
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.53273277
66Hematopoietic cell lineage_Homo sapiens_hsa046400.50932003
67Tryptophan metabolism_Homo sapiens_hsa003800.50730854
68Circadian entrainment_Homo sapiens_hsa047130.49119060
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48713626
70Autoimmune thyroid disease_Homo sapiens_hsa053200.47999602
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47869136
72Retinol metabolism_Homo sapiens_hsa008300.47182412
73Pyruvate metabolism_Homo sapiens_hsa006200.45439998
74p53 signaling pathway_Homo sapiens_hsa041150.43921212
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43753981
76mRNA surveillance pathway_Homo sapiens_hsa030150.42305657
77Amphetamine addiction_Homo sapiens_hsa050310.41896295
78Wnt signaling pathway_Homo sapiens_hsa043100.39201874
79Allograft rejection_Homo sapiens_hsa053300.37947236
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35593389
81Serotonergic synapse_Homo sapiens_hsa047260.34239336
82Morphine addiction_Homo sapiens_hsa050320.33754816
83Oocyte meiosis_Homo sapiens_hsa041140.30919731
84Hippo signaling pathway_Homo sapiens_hsa043900.29381178
85Ether lipid metabolism_Homo sapiens_hsa005650.28924944
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27651048
87HTLV-I infection_Homo sapiens_hsa051660.27304777
88Chemical carcinogenesis_Homo sapiens_hsa052040.26029566
89Cholinergic synapse_Homo sapiens_hsa047250.25837985
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25131192
91Fatty acid elongation_Homo sapiens_hsa000620.24664056
92Type I diabetes mellitus_Homo sapiens_hsa049400.24094583
93Regulation of autophagy_Homo sapiens_hsa041400.23882567
94Dopaminergic synapse_Homo sapiens_hsa047280.22576816
95N-Glycan biosynthesis_Homo sapiens_hsa005100.22001981
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21297277
97Fat digestion and absorption_Homo sapiens_hsa049750.19187770
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18671869
99Melanogenesis_Homo sapiens_hsa049160.17574649
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15788699

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