ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lactate metabolic process (GO:0006089)	6.10579257
2	behavioral response to nicotine (GO:0035095)	4.98494505
3	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.65029031
4	monoubiquitinated protein deubiquitination (GO:0035520)	4.28120804
5	indolalkylamine metabolic process (GO:0006586)	4.14829237
6	regulation of meiosis I (GO:0060631)	3.97343576
7	adaptation of signaling pathway (GO:0023058)	3.97133945
8	cellular response to interleukin-15 (GO:0071350)	3.90807713
9	replication fork processing (GO:0031297)	3.90492859
10	kynurenine metabolic process (GO:0070189)	3.89186878
11	centriole replication (GO:0007099)	3.77133209
12	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.75967781
13	isotype switching (GO:0045190)	3.75967781
14	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.75967781
15	single strand break repair (GO:0000012)	3.70227182
16	prenylation (GO:0097354)	3.67086158
17	protein prenylation (GO:0018342)	3.67086158
18	serotonin metabolic process (GO:0042428)	3.66732038
19	primary amino compound metabolic process (GO:1901160)	3.64119896
20	cell wall macromolecule catabolic process (GO:0016998)	3.52868704
21	cellular biogenic amine catabolic process (GO:0042402)	3.52695802
22	amine catabolic process (GO:0009310)	3.52695802
23	tryptophan catabolic process (GO:0006569)	3.52289166
24	indole-containing compound catabolic process (GO:0042436)	3.52289166
25	indolalkylamine catabolic process (GO:0046218)	3.52289166
26	blood vessel maturation (GO:0001955)	3.51695425
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.51524061
28	L-fucose metabolic process (GO:0042354)	3.31777617
29	L-fucose catabolic process (GO:0042355)	3.31777617
30	fucose catabolic process (GO:0019317)	3.31777617
31	protein neddylation (GO:0045116)	3.30686035
32	regulation of podosome assembly (GO:0071801)	3.28016508
33	DNA strand renaturation (GO:0000733)	3.27609860
34	transmission of nerve impulse (GO:0019226)	3.20911004
35	indole-containing compound metabolic process (GO:0042430)	3.20085855
36	protein complex biogenesis (GO:0070271)	3.20084631
37	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.19927260
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16137401
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16137401
40	NADH dehydrogenase complex assembly (GO:0010257)	3.16137401
41	protein polyglutamylation (GO:0018095)	3.14585574
42	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.13191537
43	tryptophan metabolic process (GO:0006568)	3.09225676
44	negative regulation of JUN kinase activity (GO:0043508)	3.09154104
45	cell wall macromolecule metabolic process (GO:0044036)	3.07366279
46	peptidyl-lysine trimethylation (GO:0018023)	3.06476134
47	B cell activation involved in immune response (GO:0002312)	2.98238507
48	DNA damage response, detection of DNA damage (GO:0042769)	2.96553716
49	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.90362179
50	mature B cell differentiation (GO:0002335)	2.90168202
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.90091343
52	maturation of SSU-rRNA (GO:0030490)	2.89879895
53	recombinational repair (GO:0000725)	2.86155434
54	DNA deamination (GO:0045006)	2.84309583
55	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.81869807
56	double-strand break repair via homologous recombination (GO:0000724)	2.81672457
57	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.81011441
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78582674
59	meiotic chromosome segregation (GO:0045132)	2.78545451
60	behavioral response to cocaine (GO:0048148)	2.78007266
61	retinal cone cell development (GO:0046549)	2.76632699
62	arginine catabolic process (GO:0006527)	2.73798304
63	chaperone-mediated protein transport (GO:0072321)	2.72983674
64	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.71865686
65	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	2.70903323
66	regulation of catecholamine metabolic process (GO:0042069)	2.70598747
67	regulation of dopamine metabolic process (GO:0042053)	2.70598747
68	synapsis (GO:0007129)	2.69502459
69	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.69018451
70	ER overload response (GO:0006983)	2.68819855
71	positive regulation of hair follicle development (GO:0051798)	2.67542752
72	positive regulation of hair cycle (GO:0042635)	2.67542752
73	histone H3-K9 methylation (GO:0051567)	2.66978474
74	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.65847414
75	ATP synthesis coupled proton transport (GO:0015986)	2.65847414
76	thalamus development (GO:0021794)	2.65637828
77	pseudouridine synthesis (GO:0001522)	2.64183577
78	pyrimidine dimer repair (GO:0006290)	2.62561881
79	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.62461339
80	resolution of meiotic recombination intermediates (GO:0000712)	2.62344390
81	axoneme assembly (GO:0035082)	2.61576471
82	cellular ketone body metabolic process (GO:0046950)	2.61258627
83	cellular biogenic amine biosynthetic process (GO:0042401)	2.56342674
84	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.54754707
85	respiratory chain complex IV assembly (GO:0008535)	2.54526029
86	retinal rod cell development (GO:0046548)	2.53347407
87	epithelial cilium movement (GO:0003351)	2.52311947
88	rRNA modification (GO:0000154)	2.49968384
89	cilium or flagellum-dependent cell motility (GO:0001539)	2.49007959
90	negative regulation of granulocyte differentiation (GO:0030853)	2.47935105
91	sperm motility (GO:0030317)	2.47056638
92	regulation of action potential (GO:0098900)	2.45905198
93	protein peptidyl-prolyl isomerization (GO:0000413)	2.45067177
94	cullin deneddylation (GO:0010388)	2.44994456
95	regulation of relaxation of muscle (GO:1901077)	2.42699449
96	response to interleukin-15 (GO:0070672)	2.42657739
97	peristalsis (GO:0030432)	2.42026932
98	response to pheromone (GO:0019236)	2.41492091
99	intestinal epithelial cell development (GO:0060576)	2.40820085
100	ATP biosynthetic process (GO:0006754)	2.40554144

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.90658518
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.88723033
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.85999045
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10577037
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97124866
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.87813812
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64945436
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.51826652
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.49837092
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.37869491
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.32505297
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.22131601
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.16769395
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08657352
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.88628740
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.87820168
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84253862
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81960619
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74360375
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73512540
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73041850
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.70210168
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68406199
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65873017
25	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.64133379
26	VDR_22108803_ChIP-Seq_LS180_Human	1.61168589
27	EWS_26573619_Chip-Seq_HEK293_Human	1.60667504
28	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.59542682
29	FUS_26573619_Chip-Seq_HEK293_Human	1.59481968
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58762849
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.57010982
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56050748
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.54238914
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.53467434
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52766490
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.52766490
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.49247030
38	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.48517831
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46853381
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.45859924
41	P300_19829295_ChIP-Seq_ESCs_Human	1.45340052
42	GATA3_26560356_Chip-Seq_TH2_Human	1.43926397
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.42821773
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.39308808
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.37793782
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.37738685
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.35029490
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.33573457
49	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.33050619
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31119351
51	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.31105412
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30986461
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30986461
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.28540796
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28377311
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27991332
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27167065
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26723601
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25346153
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25346153
61	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23815157
62	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.23556498
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22113304
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21616931
65	PHF8_20622853_ChIP-Seq_HELA_Human	1.19932898
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.19574392
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.19457400
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18905853
69	NFYB_21822215_ChIP-Seq_K562_Human	1.15747782
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.15615510
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14733984
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14719049
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13998971
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13335373
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.12705551
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11928806
77	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.11701995
78	TTF2_22483619_ChIP-Seq_HELA_Human	1.11690708
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11151549
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11151549
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09485158
82	NCOR_22424771_ChIP-Seq_293T_Human	1.09003743
83	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06049977
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03746119
85	STAT3_23295773_ChIP-Seq_U87_Human	1.02569529
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02395072
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01963137
88	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01387995
89	GABP_19822575_ChIP-Seq_HepG2_Human	1.00150110
90	AR_25329375_ChIP-Seq_VCAP_Human	1.00132355
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99425224
92	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98405515
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97136926
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97017849
95	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.96821304
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96321115
97	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95827691
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94670516
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93538807
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.93044172

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.29876528
2	MP0003787_abnormal_imprinting	3.60069996
3	MP0003950_abnormal_plasma_membrane	3.32934652
4	MP0005670_abnormal_white_adipose	2.94132622
5	MP0006292_abnormal_olfactory_placode	2.92006011
6	MP0001835_abnormal_antigen_presentation	2.86121343
7	MP0001968_abnormal_touch/_nociception	2.79306266
8	MP0002736_abnormal_nociception_after	2.61399651
9	MP0002102_abnormal_ear_morphology	2.46275431
10	MP0005410_abnormal_fertilization	2.43874362
11	MP0002234_abnormal_pharynx_morphology	2.39608448
12	MP0005551_abnormal_eye_electrophysiolog	2.34250877
13	MP0005647_abnormal_sex_gland	2.31082624
14	MP0005671_abnormal_response_to	2.12555133
15	MP0008007_abnormal_cellular_replicative	2.03421585
16	MP0001764_abnormal_homeostasis	1.91104660
17	MP0010094_abnormal_chromosome_stability	1.90329820
18	MP0003195_calcinosis	1.87452262
19	MP0008058_abnormal_DNA_repair	1.87353382
20	MP0003646_muscle_fatigue	1.84776207
21	MP0002163_abnormal_gland_morphology	1.75138792
22	MP0001800_abnormal_humoral_immune	1.70812445
23	MP0008789_abnormal_olfactory_epithelium	1.68909447
24	MP0008872_abnormal_physiological_respon	1.68704784
25	MP0008057_abnormal_DNA_replication	1.61890263
26	MP0000569_abnormal_digit_pigmentation	1.61044402
27	MP0002653_abnormal_ependyma_morphology	1.59055496
28	MP0005423_abnormal_somatic_nervous	1.57475711
29	MP0006276_abnormal_autonomic_nervous	1.48667527
30	MP0000685_abnormal_immune_system	1.48583999
31	MP0005174_abnormal_tail_pigmentation	1.36761994
32	MP0006036_abnormal_mitochondrial_physio	1.35914481
33	MP0009333_abnormal_splenocyte_physiolog	1.35613988
34	MP0008775_abnormal_heart_ventricle	1.32616122
35	MP0004145_abnormal_muscle_electrophysio	1.32352928
36	MP0008875_abnormal_xenobiotic_pharmacok	1.30129996
37	MP0005389_reproductive_system_phenotype	1.29521302
38	MP0002638_abnormal_pupillary_reflex	1.29068023
39	MP0009697_abnormal_copulation	1.27817591
40	MP0005084_abnormal_gallbladder_morpholo	1.26603249
41	MP0000372_irregular_coat_pigmentation	1.25607906
42	MP0004043_abnormal_pH_regulation	1.23577380
43	MP0000015_abnormal_ear_pigmentation	1.20384338
44	MP0001986_abnormal_taste_sensitivity	1.17342058
45	MP0009764_decreased_sensitivity_to	1.13546055
46	MP0002095_abnormal_skin_pigmentation	1.10899649
47	MP0001905_abnormal_dopamine_level	1.08907083
48	MP0001929_abnormal_gametogenesis	1.08562355
49	MP0002160_abnormal_reproductive_system	1.08339953
50	MP0005253_abnormal_eye_physiology	1.08046682
51	MP0003077_abnormal_cell_cycle	1.07890826
52	MP0001919_abnormal_reproductive_system	1.07759485
53	MP0005499_abnormal_olfactory_system	1.07539448
54	MP0005394_taste/olfaction_phenotype	1.07539448
55	MP0003186_abnormal_redox_activity	1.07494190
56	MP0010030_abnormal_orbit_morphology	1.04409196
57	MP0001501_abnormal_sleep_pattern	1.01881710
58	MP0000427_abnormal_hair_cycle	1.01554958
59	MP0005075_abnormal_melanosome_morpholog	1.01485426
60	MP0002148_abnormal_hypersensitivity_rea	0.99547172
61	MP0001790_abnormal_immune_system	0.98459962
62	MP0005387_immune_system_phenotype	0.98459962
63	MP0000371_diluted_coat_color	0.98142784
64	MP0002210_abnormal_sex_determination	0.93397872
65	MP0001119_abnormal_female_reproductive	0.90002558
66	MP0005000_abnormal_immune_tolerance	0.89690501
67	MP0002452_abnormal_antigen_presenting	0.89610954
68	MP0002723_abnormal_immune_serum	0.89366931
69	MP0001293_anophthalmia	0.88500225
70	MP0003698_abnormal_male_reproductive	0.87917126
71	MP0010307_abnormal_tumor_latency	0.87699023
72	MP0006035_abnormal_mitochondrial_morpho	0.87647897
73	MP0002928_abnormal_bile_duct	0.87424357
74	MP0003878_abnormal_ear_physiology	0.86751469
75	MP0005377_hearing/vestibular/ear_phenot	0.86751469
76	MP0002006_tumorigenesis	0.86097240
77	MP0000653_abnormal_sex_gland	0.83426716
78	MP0008995_early_reproductive_senescence	0.83228937
79	MP0001486_abnormal_startle_reflex	0.82527666
80	MP0003121_genomic_imprinting	0.80080303
81	MP0003718_maternal_effect	0.79895330
82	MP0001853_heart_inflammation	0.78993737
83	MP0002136_abnormal_kidney_physiology	0.77936142
84	MP0009379_abnormal_foot_pigmentation	0.76768864
85	MP0003252_abnormal_bile_duct	0.76126695
86	MP0003786_premature_aging	0.74647666
87	MP0009785_altered_susceptibility_to	0.72669399
88	MP0009745_abnormal_behavioral_response	0.72376178
89	MP0004782_abnormal_surfactant_physiolog	0.70818102
90	MP0002420_abnormal_adaptive_immunity	0.70454890
91	MP0000613_abnormal_salivary_gland	0.68398704
92	MP0004142_abnormal_muscle_tone	0.68323876
93	MP0004808_abnormal_hematopoietic_stem	0.68245654
94	MP0001819_abnormal_immune_cell	0.67059823
95	MP0000689_abnormal_spleen_morphology	0.66901100
96	MP0003567_abnormal_fetal_cardiomyocyte	0.66736608
97	MP0005167_abnormal_blood-brain_barrier	0.66277988
98	MP0001145_abnormal_male_reproductive	0.65993888
99	MP0009643_abnormal_urine_homeostasis	0.65310189
100	MP0001661_extended_life_span	0.63962960

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	4.33309831
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.30821406
3	Pancreatic cysts (HP:0001737)	4.28501651
4	Oligodactyly (hands) (HP:0001180)	4.11905212
5	Pancreatic fibrosis (HP:0100732)	4.05219200
6	Chronic hepatic failure (HP:0100626)	3.55909747
7	True hermaphroditism (HP:0010459)	3.43406992
8	Duplicated collecting system (HP:0000081)	3.38731387
9	Abnormality of the renal collecting system (HP:0004742)	3.34262336
10	Chronic sinusitis (HP:0011109)	3.34099378
11	Abnormality of chromosome stability (HP:0003220)	3.05732911
12	Wide intermamillary distance (HP:0006610)	2.98818098
13	Cystic liver disease (HP:0006706)	2.83447988
14	Tubulointerstitial fibrosis (HP:0005576)	2.79387670
15	Shawl scrotum (HP:0000049)	2.76077558
16	Oligodactyly (HP:0012165)	2.75142808
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71095598
18	Tubular atrophy (HP:0000092)	2.67809107
19	Abnormality of the ileum (HP:0001549)	2.66570621
20	Thyroiditis (HP:0100646)	2.66532596
21	Tubulointerstitial abnormality (HP:0001969)	2.66178736
22	Meckel diverticulum (HP:0002245)	2.65042088
23	Recurrent sinusitis (HP:0011108)	2.64531344
24	Agammaglobulinemia (HP:0004432)	2.57084519
25	3-Methylglutaconic aciduria (HP:0003535)	2.56887994
26	Reticulocytopenia (HP:0001896)	2.56466185
27	Increased CSF lactate (HP:0002490)	2.55456159
28	Volvulus (HP:0002580)	2.52464165
29	Supernumerary spleens (HP:0009799)	2.44049265
30	Enlarged kidneys (HP:0000105)	2.39296691
31	Acute necrotizing encephalopathy (HP:0006965)	2.36760746
32	Lipid accumulation in hepatocytes (HP:0006561)	2.36166853
33	Clumsiness (HP:0002312)	2.35852470
34	Chronic diarrhea (HP:0002028)	2.35832986
35	Severe combined immunodeficiency (HP:0004430)	2.34902521
36	Mitochondrial inheritance (HP:0001427)	2.33635226
37	Molar tooth sign on MRI (HP:0002419)	2.32690250
38	Abnormality of midbrain morphology (HP:0002418)	2.32690250
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30378487
40	Carpal bone hypoplasia (HP:0001498)	2.29952266
41	Ureteral duplication (HP:0000073)	2.26735600
42	Methylmalonic acidemia (HP:0002912)	2.25730574
43	Fair hair (HP:0002286)	2.24069642
44	Sloping forehead (HP:0000340)	2.24028889
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20699321
46	Abnormality of the pons (HP:0007361)	2.20308528
47	Hypoproteinemia (HP:0003075)	2.17423937
48	Absent speech (HP:0001344)	2.16251370
49	Neutropenia (HP:0001875)	2.15999699
50	Attenuation of retinal blood vessels (HP:0007843)	2.13431829
51	Progressive macrocephaly (HP:0004481)	2.12838754
52	Asplenia (HP:0001746)	2.12115027
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11165646
54	Absent/shortened dynein arms (HP:0200106)	2.11165646
55	Opisthotonus (HP:0002179)	2.09953618
56	Methylmalonic aciduria (HP:0012120)	2.07373588
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06583423
58	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.06175366
59	Abnormality of macular pigmentation (HP:0008002)	2.05668972
60	Abnormality of the labia minora (HP:0012880)	2.05301641
61	Acute encephalopathy (HP:0006846)	2.04961208
62	Abnormality of pyrimidine metabolism (HP:0004353)	2.04349373
63	Male pseudohermaphroditism (HP:0000037)	2.01499069
64	Absent thumb (HP:0009777)	2.01393513
65	Abnormality of the preputium (HP:0100587)	1.99776596
66	Small hand (HP:0200055)	1.99543777
67	Nausea (HP:0002018)	1.99219488
68	Renal Fanconi syndrome (HP:0001994)	1.99045216
69	Abnormal ciliary motility (HP:0012262)	1.98975981
70	Abnormality of cells of the erythroid lineage (HP:0012130)	1.98662480
71	Abnormal number of erythroid precursors (HP:0012131)	1.98447870
72	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.97618429
73	Type II lissencephaly (HP:0007260)	1.97317336
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96830183
75	B lymphocytopenia (HP:0010976)	1.93196892
76	Increased hepatocellular lipid droplets (HP:0006565)	1.93056465
77	Combined immunodeficiency (HP:0005387)	1.92511321
78	Optic disc pallor (HP:0000543)	1.92118762
79	Tubulointerstitial nephritis (HP:0001970)	1.88846880
80	Pancytopenia (HP:0001876)	1.88346476
81	Abnormality of DNA repair (HP:0003254)	1.88104931
82	Protruding tongue (HP:0010808)	1.86868864
83	Anophthalmia (HP:0000528)	1.85072566
84	Congenital hepatic fibrosis (HP:0002612)	1.84872350
85	Anencephaly (HP:0002323)	1.83365107
86	Congenital stationary night blindness (HP:0007642)	1.82528876
87	Hyperventilation (HP:0002883)	1.81683440
88	Polydipsia (HP:0001959)	1.81400445
89	Abnormal drinking behavior (HP:0030082)	1.81400445
90	Nephronophthisis (HP:0000090)	1.81050321
91	Absent radius (HP:0003974)	1.80679558
92	Abnormality of the carotid arteries (HP:0005344)	1.80191354
93	Increased serum lactate (HP:0002151)	1.79938479
94	Horseshoe kidney (HP:0000085)	1.78629678
95	Abnormality of B cell number (HP:0010975)	1.78444738
96	Cerebral edema (HP:0002181)	1.77185407
97	Birth length less than 3rd percentile (HP:0003561)	1.75401410
98	Abnormality of alanine metabolism (HP:0010916)	1.74963257
99	Hyperalaninemia (HP:0003348)	1.74963257
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74963257

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	9.10951725
2	TRIM28	3.29174349
3	MST4	3.10807570
4	ACVR1B	3.06714439
5	MAPKAPK3	2.67603283
6	FRK	2.61383232
7	BRSK2	2.24129662
8	EIF2AK3	2.01791072
9	NEK6	1.96654255
10	CASK	1.64863573
11	EIF2AK1	1.61793616
12	CDK19	1.54940414
13	TLK1	1.50159932
14	TEC	1.46226760
15	MARK3	1.44992551
16	IRAK1	1.42830820
17	GRK1	1.41207702
18	WNK4	1.33883034
19	NME1	1.28257289
20	CAMK1D	1.27438270
21	TNIK	1.26423365
22	MAP3K2	1.24876110
23	OXSR1	1.17857168
24	TXK	1.10090819
25	WNK1	1.08491376
26	ADRBK2	1.00223850
27	FLT3	0.97168297
28	TAOK3	0.97164619
29	CAMK1G	0.95937733
30	BMPR1B	0.95814184
31	MAPK7	0.93330099
32	PLK4	0.91453037
33	MAPK12	0.90213715
34	MAP2K2	0.89413600
35	OBSCN	0.88426536
36	WEE1	0.85893644
37	JAK3	0.85115863
38	PKN1	0.84958825
39	BTK	0.84934771
40	ITK	0.83845990
41	PLK2	0.83055215
42	MAPK13	0.80489692
43	PTK2B	0.78979331
44	ERBB3	0.76041688
45	GRK7	0.75885475
46	MKNK2	0.75542495
47	BRSK1	0.71001104
48	HCK	0.70443583
49	ZAK	0.66253619
50	NUAK1	0.66197422
51	MAP3K12	0.65584773
52	PLK1	0.65080081
53	NTRK2	0.61761251
54	MAP3K5	0.61304959
55	TTK	0.60155410
56	MAP4K1	0.58965836
57	IKBKB	0.55837273
58	PRKCI	0.55620573
59	MAP2K6	0.53908559
60	SYK	0.53755373
61	CAMK1	0.53707839
62	JAK1	0.53463368
63	SCYL2	0.53038152
64	ATM	0.50317562
65	MINK1	0.50192398
66	HIPK2	0.49860761
67	CDK3	0.49253530
68	TRPM7	0.48096668
69	PLK3	0.46733462
70	SRPK1	0.46595192
71	STK16	0.45231545
72	DYRK1A	0.44524268
73	TSSK6	0.42556715
74	NTRK3	0.42131909
75	PRKCQ	0.41982143
76	PDK1	0.41418984
77	AURKB	0.40313426
78	PRKAA1	0.40185308
79	PKN2	0.39982881
80	ABL1	0.39147733
81	PINK1	0.38845958
82	PNCK	0.38572457
83	CSF1R	0.37493128
84	TAOK2	0.36437855
85	ATR	0.36356801
86	EIF2AK2	0.36329974
87	PIK3CG	0.35509450
88	DYRK3	0.34828339
89	STK39	0.34803082
90	PRKACB	0.34444285
91	TYK2	0.33186625
92	PRKAA2	0.32863802
93	PRKCE	0.31380941
94	MAPK14	0.31185767
95	IKBKE	0.30655910
96	CHEK1	0.30620972
97	CDK2	0.29660775
98	CSNK2A1	0.29645109
99	PIK3CA	0.29534673
100	EPHB2	0.29317098

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.03862690
2	Asthma_Homo sapiens_hsa05310	3.33090587
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.67549865
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62696811
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.44654667
6	Protein export_Homo sapiens_hsa03060	2.40652356
7	RNA polymerase_Homo sapiens_hsa03020	2.27890492
8	Parkinsons disease_Homo sapiens_hsa05012	2.26774810
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.26478136
10	Allograft rejection_Homo sapiens_hsa05330	2.26138643
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.17520783
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.12311930
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.91946534
14	Proteasome_Homo sapiens_hsa03050	1.90432854
15	One carbon pool by folate_Homo sapiens_hsa00670	1.89976011
16	Propanoate metabolism_Homo sapiens_hsa00640	1.87618689
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82270378
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.80607959
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80460910
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.80292875
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.79898466
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70298685
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.68953459
24	Huntingtons disease_Homo sapiens_hsa05016	1.56937534
25	Phototransduction_Homo sapiens_hsa04744	1.55792565
26	Mismatch repair_Homo sapiens_hsa03430	1.54408949
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49131159
28	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.49029066
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48680257
30	Alzheimers disease_Homo sapiens_hsa05010	1.41833729
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.40355486
32	Olfactory transduction_Homo sapiens_hsa04740	1.40016027
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.37572402
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32915531
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29007469
36	Regulation of autophagy_Homo sapiens_hsa04140	1.28028032
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27292725
38	Basal transcription factors_Homo sapiens_hsa03022	1.26619632
39	RNA degradation_Homo sapiens_hsa03018	1.26442392
40	Ribosome_Homo sapiens_hsa03010	1.25786156
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23471573
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.21459166
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15359248
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.13747162
45	Fatty acid metabolism_Homo sapiens_hsa01212	1.12957853
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.09704428
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97034478
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.96302385
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96146865
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95993514
51	Spliceosome_Homo sapiens_hsa03040	0.94429049
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.90961433
53	DNA replication_Homo sapiens_hsa03030	0.85197339
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.81451806
55	Fatty acid elongation_Homo sapiens_hsa00062	0.80913835
56	Caffeine metabolism_Homo sapiens_hsa00232	0.80738373
57	Purine metabolism_Homo sapiens_hsa00230	0.79167385
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75166174
59	PPAR signaling pathway_Homo sapiens_hsa03320	0.74924733
60	Peroxisome_Homo sapiens_hsa04146	0.69805870
61	Viral myocarditis_Homo sapiens_hsa05416	0.68594239
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68029845
63	Leishmaniasis_Homo sapiens_hsa05140	0.65797677
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65376535
65	RNA transport_Homo sapiens_hsa03013	0.65219831
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64186220
67	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64108293
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63345823
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61195746
70	Butanoate metabolism_Homo sapiens_hsa00650	0.60451949
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60404674
72	Metabolic pathways_Homo sapiens_hsa01100	0.55702675
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55480856
74	Legionellosis_Homo sapiens_hsa05134	0.50276012
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49257808
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47986648
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47042687
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46698899
79	Tuberculosis_Homo sapiens_hsa05152	0.45383838
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44672225
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43869224
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43190709
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.43146871
84	Fatty acid degradation_Homo sapiens_hsa00071	0.42095685
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41797500
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41615090
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40937109
88	Taste transduction_Homo sapiens_hsa04742	0.38736068
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38380697
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37866150
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34190089
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33159758
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.32906556
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32323840
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.32107922
96	African trypanosomiasis_Homo sapiens_hsa05143	0.32037967
97	Base excision repair_Homo sapiens_hsa03410	0.29953917
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29030806
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27452704
100	Circadian rhythm_Homo sapiens_hsa04710	0.27425964

RPSAP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »