RPSAP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.95572039
2ATP synthesis coupled proton transport (GO:0015986)6.95016781
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.95016781
4ribosomal small subunit assembly (GO:0000028)6.93451071
5establishment of protein localization to mitochondrial membrane (GO:0090151)6.09495077
6viral transcription (GO:0019083)5.70577852
7translational termination (GO:0006415)5.55359222
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.52942948
9chaperone-mediated protein transport (GO:0072321)5.38076315
10respiratory electron transport chain (GO:0022904)5.14074710
11protein complex biogenesis (GO:0070271)5.09825066
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08594687
13electron transport chain (GO:0022900)5.06064548
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.05096369
15mitochondrial respiratory chain complex I assembly (GO:0032981)5.05096369
16NADH dehydrogenase complex assembly (GO:0010257)5.05096369
17protein targeting to ER (GO:0045047)4.98929961
18cotranslational protein targeting to membrane (GO:0006613)4.97632589
19ribosomal small subunit biogenesis (GO:0042274)4.87032984
20translational elongation (GO:0006414)4.81944645
21DNA deamination (GO:0045006)4.79271394
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.76634621
23protein localization to endoplasmic reticulum (GO:0070972)4.74867727
24mitochondrial respiratory chain complex assembly (GO:0033108)4.69490089
25ribosomal large subunit biogenesis (GO:0042273)4.60632441
26protein neddylation (GO:0045116)4.34019489
27maturation of SSU-rRNA (GO:0030490)4.33330995
28cellular protein complex disassembly (GO:0043624)4.20170496
29viral life cycle (GO:0019058)4.15544118
30translational initiation (GO:0006413)4.06836130
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.03333217
32translation (GO:0006412)4.00163785
33respiratory chain complex IV assembly (GO:0008535)3.94489295
34ATP biosynthetic process (GO:0006754)3.91787340
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84801378
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.81404034
37hydrogen ion transmembrane transport (GO:1902600)3.74479867
38proteasome assembly (GO:0043248)3.63188042
39GTP biosynthetic process (GO:0006183)3.62679167
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.61317911
41cytochrome complex assembly (GO:0017004)3.56334506
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.54653354
43termination of RNA polymerase III transcription (GO:0006386)3.54653354
44protein complex disassembly (GO:0043241)3.46847925
45cellular component biogenesis (GO:0044085)3.45332721
46water-soluble vitamin biosynthetic process (GO:0042364)3.45329821
47ribonucleoside triphosphate biosynthetic process (GO:0009201)3.39330974
48macromolecular complex disassembly (GO:0032984)3.36074463
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35787362
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35787362
51protein targeting to membrane (GO:0006612)3.34610419
52proton transport (GO:0015992)3.34394341
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33368669
54peptidyl-histidine modification (GO:0018202)3.32156986
55hydrogen transport (GO:0006818)3.28120162
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27062308
57oxidative phosphorylation (GO:0006119)3.18645656
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14750863
59regulation of cellular amino acid metabolic process (GO:0006521)3.07601668
60aldehyde catabolic process (GO:0046185)3.07090702
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.05384829
62UTP metabolic process (GO:0046051)3.04930142
63UTP biosynthetic process (GO:0006228)3.04493477
64deoxyribose phosphate catabolic process (GO:0046386)3.01485913
65ribonucleoprotein complex biogenesis (GO:0022613)2.99994334
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96926340
67intracellular protein transmembrane import (GO:0044743)2.95832921
68nucleoside triphosphate biosynthetic process (GO:0009142)2.94833326
69pyrimidine nucleotide catabolic process (GO:0006244)2.94652600
70mannosylation (GO:0097502)2.93976852
71protein-cofactor linkage (GO:0018065)2.91333051
72deoxyribonucleotide catabolic process (GO:0009264)2.89456315
73mRNA catabolic process (GO:0006402)2.89353360
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87848224
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87848224
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87848224
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85739373
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85732350
79negative regulation of ligase activity (GO:0051352)2.85732350
80protein targeting to mitochondrion (GO:0006626)2.85576864
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85177091
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85177091
83rRNA processing (GO:0006364)2.82754772
84viral mRNA export from host cell nucleus (GO:0046784)2.82158243
85regulation of mitochondrial translation (GO:0070129)2.82063533
86protein localization to mitochondrion (GO:0070585)2.82017017
87guanosine-containing compound biosynthetic process (GO:1901070)2.81919788
88establishment of protein localization to mitochondrion (GO:0072655)2.81537706
89rRNA metabolic process (GO:0016072)2.76022234
90rRNA modification (GO:0000154)2.75721189
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74288754
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.74288754
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74177064
94platelet dense granule organization (GO:0060155)2.73862611
95RNA catabolic process (GO:0006401)2.73459252
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.72035116
97behavioral response to nicotine (GO:0035095)2.69461612
98base-excision repair, AP site formation (GO:0006285)2.68684917
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67490331
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67351602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.57235847
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.46080744
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38881824
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.86793115
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13933406
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12075518
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.05189944
8VDR_22108803_ChIP-Seq_LS180_Human2.73768374
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69658745
10VDR_23849224_ChIP-Seq_CD4+_Human2.63892110
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.63357849
12EZH2_22144423_ChIP-Seq_EOC_Human2.50085453
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39888850
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37423600
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24304409
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21115926
17ZNF274_21170338_ChIP-Seq_K562_Hela2.16289954
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.13098355
19FOXP3_21729870_ChIP-Seq_TREG_Human2.04578705
20ELK1_19687146_ChIP-ChIP_HELA_Human1.99445514
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99041707
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98514027
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88721141
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82595619
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.70004800
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69645745
27TTF2_22483619_ChIP-Seq_HELA_Human1.66684889
28MYC_18940864_ChIP-ChIP_HL60_Human1.65713859
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63362378
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.63311423
31TP53_22573176_ChIP-Seq_HFKS_Human1.62908363
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61564297
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56511818
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56415304
35IGF1R_20145208_ChIP-Seq_DFB_Human1.56127589
36GABP_19822575_ChIP-Seq_HepG2_Human1.49001500
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.48939598
38EWS_26573619_Chip-Seq_HEK293_Human1.48102453
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43680013
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38681613
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37436828
42IRF1_19129219_ChIP-ChIP_H3396_Human1.36213297
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32774493
44DCP1A_22483619_ChIP-Seq_HELA_Human1.31207774
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27891819
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27840735
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.27548060
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27442878
49XRN2_22483619_ChIP-Seq_HELA_Human1.26260277
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.24592793
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24592793
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24558646
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22614237
54FUS_26573619_Chip-Seq_HEK293_Human1.21820817
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19372366
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17871807
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.16944354
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15706755
59NANOG_20526341_ChIP-Seq_ESCs_Human1.14991380
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13758007
61TAF2_19829295_ChIP-Seq_ESCs_Human1.13680245
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13568849
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12825597
64FOXH1_21741376_ChIP-Seq_EPCs_Human1.12622446
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12581135
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.11685967
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11051170
68AR_20517297_ChIP-Seq_VCAP_Human1.09578690
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08849180
70CIITA_25753668_ChIP-Seq_RAJI_Human1.06397821
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05802559
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05678116
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04991592
74NCOR_22424771_ChIP-Seq_293T_Human1.04422195
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03722881
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03699690
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.03582202
78SOX2_19829295_ChIP-Seq_ESCs_Human1.03571435
79NANOG_19829295_ChIP-Seq_ESCs_Human1.03571435
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01136937
81MYC_19829295_ChIP-Seq_ESCs_Human1.00323396
82TAF15_26573619_Chip-Seq_HEK293_Human0.99535375
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98558738
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97812535
85ERG_20517297_ChIP-Seq_VCAP_Human0.97215342
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.95545537
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93749517
88ER_23166858_ChIP-Seq_MCF-7_Human0.92166015
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91615906
90P300_19829295_ChIP-Seq_ESCs_Human0.90804545
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90016284
92ERA_21632823_ChIP-Seq_H3396_Human0.89995843
93GATA3_26560356_Chip-Seq_TH2_Human0.88799426
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88129839
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87923477
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87896399
97P53_21459846_ChIP-Seq_SAOS-2_Human0.87313268
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87178299
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87112330
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87086436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.39512897
2MP0006292_abnormal_olfactory_placode3.09644035
3MP0001835_abnormal_antigen_presentation3.07535785
4MP0005671_abnormal_response_to2.97247926
5MP0002102_abnormal_ear_morphology2.64891943
6MP0004142_abnormal_muscle_tone2.61010861
7MP0002138_abnormal_hepatobiliary_system2.37102470
8MP0000372_irregular_coat_pigmentation2.31645182
9MP0003646_muscle_fatigue2.28959917
10MP0003806_abnormal_nucleotide_metabolis2.26100842
11MP0002837_dystrophic_cardiac_calcinosis2.16947904
12MP0005360_urolithiasis2.05895437
13MP0008872_abnormal_physiological_respon2.03780405
14MP0004145_abnormal_muscle_electrophysio1.99916343
15MP0006072_abnormal_retinal_apoptosis1.98710416
16MP0002163_abnormal_gland_morphology1.91786935
17MP0003880_abnormal_central_pattern1.90791826
18MP0002876_abnormal_thyroid_physiology1.84444291
19MP0002638_abnormal_pupillary_reflex1.77967629
20MP0001968_abnormal_touch/_nociception1.75378832
21MP0009333_abnormal_splenocyte_physiolog1.67371739
22MP0006036_abnormal_mitochondrial_physio1.64989551
23MP0004043_abnormal_pH_regulation1.62111430
24MP0005645_abnormal_hypothalamus_physiol1.60489563
25MP0003186_abnormal_redox_activity1.59364676
26MP0005084_abnormal_gallbladder_morpholo1.58576758
27MP0001986_abnormal_taste_sensitivity1.56928433
28MP0002938_white_spotting1.54729681
29MP0001905_abnormal_dopamine_level1.51953765
30MP0005379_endocrine/exocrine_gland_phen1.47354000
31MP0003787_abnormal_imprinting1.46080254
32MP0005551_abnormal_eye_electrophysiolog1.45117343
33MP0005646_abnormal_pituitary_gland1.43629003
34MP0001529_abnormal_vocalization1.42714504
35MP0008877_abnormal_DNA_methylation1.42193967
36MP0001348_abnormal_lacrimal_gland1.41172611
37MP0001873_stomach_inflammation1.39820677
38MP0008875_abnormal_xenobiotic_pharmacok1.39714673
39MP0008058_abnormal_DNA_repair1.39643910
40MP0002277_abnormal_respiratory_mucosa1.38875519
41MP0003878_abnormal_ear_physiology1.36983863
42MP0005377_hearing/vestibular/ear_phenot1.36983863
43MP0008789_abnormal_olfactory_epithelium1.35849769
44MP0001800_abnormal_humoral_immune1.35163268
45MP0002234_abnormal_pharynx_morphology1.29571544
46MP0005075_abnormal_melanosome_morpholog1.29126170
47MP0002736_abnormal_nociception_after1.25573172
48MP0002095_abnormal_skin_pigmentation1.25015000
49MP0004885_abnormal_endolymph1.23948429
50MP0006276_abnormal_autonomic_nervous1.23380150
51MP0002272_abnormal_nervous_system1.22308238
52MP0001919_abnormal_reproductive_system1.19055664
53MP0002166_altered_tumor_susceptibility1.16123113
54MP0005670_abnormal_white_adipose1.11693335
55MP0001970_abnormal_pain_threshold1.10103110
56MP0002733_abnormal_thermal_nociception1.09952504
57MP0001440_abnormal_grooming_behavior1.09418253
58MP0005253_abnormal_eye_physiology1.08102003
59MP0009745_abnormal_behavioral_response1.06965534
60MP0009785_altered_susceptibility_to1.05053331
61MP0003693_abnormal_embryo_hatching1.03841482
62MP0002006_tumorigenesis1.01697019
63MP0005387_immune_system_phenotype1.00023106
64MP0001790_abnormal_immune_system1.00023106
65MP0003136_yellow_coat_color0.96997873
66MP0004147_increased_porphyrin_level0.96490194
67MP0002148_abnormal_hypersensitivity_rea0.96344037
68MP0005389_reproductive_system_phenotype0.95800650
69MP0000685_abnormal_immune_system0.95100406
70MP0001485_abnormal_pinna_reflex0.92805886
71MP0003786_premature_aging0.92185936
72MP0003121_genomic_imprinting0.87579661
73MP0006035_abnormal_mitochondrial_morpho0.86491215
74MP0003123_paternal_imprinting0.86441222
75MP0001984_abnormal_olfaction0.85630313
76MP0005394_taste/olfaction_phenotype0.85236288
77MP0005499_abnormal_olfactory_system0.85236288
78MP0009764_decreased_sensitivity_to0.83315414
79MP0005332_abnormal_amino_acid0.82004841
80MP0003195_calcinosis0.81495440
81MP0005000_abnormal_immune_tolerance0.80994900
82MP0002735_abnormal_chemical_nociception0.80960471
83MP0000631_abnormal_neuroendocrine_gland0.80791000
84MP0001486_abnormal_startle_reflex0.80675263
85MP0008775_abnormal_heart_ventricle0.80406302
86MP0003718_maternal_effect0.77477059
87MP0003567_abnormal_fetal_cardiomyocyte0.77094686
88MP0010094_abnormal_chromosome_stability0.75397726
89MP0004133_heterotaxia0.74956490
90MP0002723_abnormal_immune_serum0.73981842
91MP0002653_abnormal_ependyma_morphology0.73649215
92MP0005174_abnormal_tail_pigmentation0.72827269
93MP0001188_hyperpigmentation0.71800681
94MP0005636_abnormal_mineral_homeostasis0.71533967
95MP0009046_muscle_twitch0.69946475
96MP0001661_extended_life_span0.68191023
97MP0002452_abnormal_antigen_presenting0.68118921
98MP0001293_anophthalmia0.67390172
99MP0000049_abnormal_middle_ear0.66837122
100MP0001764_abnormal_homeostasis0.65977998

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.86342277
2Abnormal mitochondria in muscle tissue (HP:0008316)5.24969232
3Mitochondrial inheritance (HP:0001427)5.21640946
4Acute encephalopathy (HP:0006846)4.86094005
5Progressive macrocephaly (HP:0004481)4.79231389
6Increased CSF lactate (HP:0002490)4.76255730
7Hepatocellular necrosis (HP:0001404)4.58259123
8Hepatic necrosis (HP:0002605)4.15774397
9Increased hepatocellular lipid droplets (HP:0006565)4.07594824
10Cerebral edema (HP:0002181)3.88136531
11Lipid accumulation in hepatocytes (HP:0006561)3.84960780
123-Methylglutaconic aciduria (HP:0003535)3.70322322
13Reticulocytopenia (HP:0001896)3.34331000
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.27740753
15Increased serum lactate (HP:0002151)3.23225570
16Renal Fanconi syndrome (HP:0001994)3.22486243
17Optic disc pallor (HP:0000543)3.18548521
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16122070
19Lactic acidosis (HP:0003128)2.95085276
20Leukodystrophy (HP:0002415)2.92173337
21Respiratory failure (HP:0002878)2.90499368
22B lymphocytopenia (HP:0010976)2.89337138
23Exertional dyspnea (HP:0002875)2.85039570
24Increased intramyocellular lipid droplets (HP:0012240)2.83435308
25Pancreatic cysts (HP:0001737)2.82636259
26Abnormality of midbrain morphology (HP:0002418)2.81690372
27Molar tooth sign on MRI (HP:0002419)2.81690372
28Abnormal rod and cone electroretinograms (HP:0008323)2.73450478
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72479291
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72479291
31Abnormality of cells of the erythroid lineage (HP:0012130)2.69307486
32Macrocytic anemia (HP:0001972)2.66069556
33Abnormality of B cell number (HP:0010975)2.61595641
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58271651
35Exercise intolerance (HP:0003546)2.52787576
36Congenital, generalized hypertrichosis (HP:0004540)2.50521013
37Nephronophthisis (HP:0000090)2.46814488
38Lethargy (HP:0001254)2.43618798
39Increased muscle lipid content (HP:0009058)2.42895219
40Pancreatic fibrosis (HP:0100732)2.38999745
41Hypoproteinemia (HP:0003075)2.36958486
42True hermaphroditism (HP:0010459)2.33455323
43Aplastic anemia (HP:0001915)2.30295981
44Abolished electroretinogram (ERG) (HP:0000550)2.29623561
45Type II lissencephaly (HP:0007260)2.28963924
46Congenital stationary night blindness (HP:0007642)2.28644162
47Abnormality of urine glucose concentration (HP:0011016)2.26139615
48Glycosuria (HP:0003076)2.26139615
49Abnormal number of erythroid precursors (HP:0012131)2.25650727
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.25314886
51Absent/shortened dynein arms (HP:0200106)2.25314886
52Abnormality of renal resorption (HP:0011038)2.23893541
53Panhypogammaglobulinemia (HP:0003139)2.21679274
54Respiratory difficulties (HP:0002880)2.20833970
55Pallor (HP:0000980)2.20597401
56IgG deficiency (HP:0004315)2.19790983
57CNS demyelination (HP:0007305)2.18166682
58Methylmalonic aciduria (HP:0012120)2.17893661
59Constricted visual fields (HP:0001133)2.11192887
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.02565406
61Asplenia (HP:0001746)2.01978945
62Severe combined immunodeficiency (HP:0004430)2.01732896
63Elevated erythrocyte sedimentation rate (HP:0003565)2.00603757
64Parakeratosis (HP:0001036)1.99839674
65Medial flaring of the eyebrow (HP:0010747)1.99738836
66Methylmalonic acidemia (HP:0002912)1.99204528
67Chronic sinusitis (HP:0011109)1.98521499
68Abnormal respiratory motile cilium morphology (HP:0005938)1.98156727
69Abnormal respiratory epithelium morphology (HP:0012253)1.98156727
70Cleft eyelid (HP:0000625)1.96551635
71Abnormality of the renal medulla (HP:0100957)1.93752585
72Absent thumb (HP:0009777)1.91937912
73Type 2 muscle fiber atrophy (HP:0003554)1.88877661
74Aplasia/hypoplasia of the uterus (HP:0008684)1.87671014
75Progressive microcephaly (HP:0000253)1.86830056
76Supernumerary spleens (HP:0009799)1.86728518
77Failure to thrive in infancy (HP:0001531)1.86367331
78Generalized aminoaciduria (HP:0002909)1.82285971
79Thyroiditis (HP:0100646)1.82051396
80Delayed CNS myelination (HP:0002188)1.81212527
81Microvesicular hepatic steatosis (HP:0001414)1.80725743
82Pendular nystagmus (HP:0012043)1.79881423
83Abnormal ciliary motility (HP:0012262)1.78849039
84Abnormal respiratory motile cilium physiology (HP:0012261)1.78323145
85Cerebellar dysplasia (HP:0007033)1.75272770
86Attenuation of retinal blood vessels (HP:0007843)1.75137832
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74794075
88Dicarboxylic aciduria (HP:0003215)1.74443040
89Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74443040
90Hypomagnesemia (HP:0002917)1.73416568
91Cerebral hypomyelination (HP:0006808)1.73116078
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72800807
93Abnormality of magnesium homeostasis (HP:0004921)1.71126312
94Polydipsia (HP:0001959)1.70568287
95Abnormal drinking behavior (HP:0030082)1.70568287
96Abnormality of the renal cortex (HP:0011035)1.68434820
97X-linked dominant inheritance (HP:0001423)1.67169880
98Hyperphosphaturia (HP:0003109)1.66815111
99Emotional lability (HP:0000712)1.66792680
100Sclerocornea (HP:0000647)1.64650450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.45223126
2MAP3K123.20944627
3ZAK3.10713358
4CDK193.07957659
5BMPR1B2.67197247
6STK162.52178846
7VRK22.22896832
8ADRBK22.16980643
9BCKDK2.09521923
10TXK2.08031173
11WNK42.01866551
12DYRK21.92088125
13CDK81.91165676
14GRK11.85558642
15BMPR21.81694023
16MAP4K21.80975097
17NUAK11.69654585
18VRK11.65456999
19CDC71.65072783
20WNK31.59130798
21EIF2AK31.58792205
22TAOK31.52677139
23NME11.44995715
24FRK1.31297347
25PIK3CG1.27339473
26TRIM281.27227711
27BUB11.25872559
28PINK11.25430563
29MYLK1.25412014
30PLK41.24960014
31OXSR11.23524051
32MAP4K11.21676385
33SCYL21.21326428
34ILK1.18603388
35MST41.17741925
36KDR1.12550010
37DAPK31.12541698
38NME21.09118677
39NEK11.05903711
40TEC1.04180054
41LIMK11.01788158
42SRPK11.01409196
43ITK1.00466191
44DAPK10.91182823
45PHKG10.90721286
46PHKG20.90721286
47ABL20.90361229
48STK390.89968664
49TNIK0.86588706
50TAF10.85648353
51MAP3K40.85572847
52TGFBR10.84817148
53PRKCG0.76405311
54SYK0.76238143
55RPS6KA50.75199975
56CSF1R0.71100653
57INSRR0.71030786
58TESK20.70384323
59ADRBK10.68873742
60ATR0.68177207
61MAPK130.67939333
62PRKCQ0.67084848
63RPS6KA40.66722561
64PLK30.65322858
65GRK60.63834158
66BCR0.63236141
67PASK0.61111796
68CSNK2A20.59837584
69CSNK1G20.59475651
70PRKCE0.58244703
71MKNK20.57843321
72DYRK30.57470255
73MINK10.56527470
74EIF2AK10.56495267
75EIF2AK20.56071592
76MAP2K60.55901929
77BTK0.55803228
78MKNK10.55670283
79AURKB0.54223475
80TSSK60.53607603
81ERBB30.51552397
82CSNK2A10.50643797
83DAPK20.50059038
84PBK0.48901047
85PLK10.48874265
86CSNK1G30.47640847
87RIPK40.47603806
88LYN0.47521738
89CASK0.45124716
90MAP2K70.44522945
91FLT30.44244883
92MARK10.43914949
93CAMK10.43673849
94MUSK0.43354007
95PRKACA0.42524655
96KIT0.41621708
97IKBKB0.41523536
98OBSCN0.40952862
99PKN10.39769008
100LCK0.39450894

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54760479
2Oxidative phosphorylation_Homo sapiens_hsa001904.37363186
3Proteasome_Homo sapiens_hsa030503.81705203
4Parkinsons disease_Homo sapiens_hsa050123.79420267
5Asthma_Homo sapiens_hsa053103.41591590
6Protein export_Homo sapiens_hsa030602.78572244
7Allograft rejection_Homo sapiens_hsa053302.67413011
8RNA polymerase_Homo sapiens_hsa030202.61016028
9Alzheimers disease_Homo sapiens_hsa050102.49037834
10Huntingtons disease_Homo sapiens_hsa050162.48025314
11Autoimmune thyroid disease_Homo sapiens_hsa053202.44164894
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.40154330
13Graft-versus-host disease_Homo sapiens_hsa053322.20817607
14Type I diabetes mellitus_Homo sapiens_hsa049402.17813246
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13270429
16Cardiac muscle contraction_Homo sapiens_hsa042602.04975967
17Homologous recombination_Homo sapiens_hsa034401.71992816
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60105973
19DNA replication_Homo sapiens_hsa030301.43634041
20Pyrimidine metabolism_Homo sapiens_hsa002401.40801276
21Phototransduction_Homo sapiens_hsa047441.38022960
22RNA degradation_Homo sapiens_hsa030181.35390370
23One carbon pool by folate_Homo sapiens_hsa006701.32172721
24Primary immunodeficiency_Homo sapiens_hsa053401.29625245
25Antigen processing and presentation_Homo sapiens_hsa046121.24126069
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22526535
27Mismatch repair_Homo sapiens_hsa034301.15805759
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15610238
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10475595
30Rheumatoid arthritis_Homo sapiens_hsa053231.09314884
31Linoleic acid metabolism_Homo sapiens_hsa005911.07914902
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07097469
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05897998
34Fanconi anemia pathway_Homo sapiens_hsa034601.03917423
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03436945
36Purine metabolism_Homo sapiens_hsa002300.97896925
37Non-homologous end-joining_Homo sapiens_hsa034500.97426730
38Regulation of autophagy_Homo sapiens_hsa041400.95960236
39Spliceosome_Homo sapiens_hsa030400.95924217
40Basal transcription factors_Homo sapiens_hsa030220.93825785
41Nucleotide excision repair_Homo sapiens_hsa034200.93149280
42Base excision repair_Homo sapiens_hsa034100.91914114
43Sulfur relay system_Homo sapiens_hsa041220.91162595
44RNA transport_Homo sapiens_hsa030130.90921758
45Systemic lupus erythematosus_Homo sapiens_hsa053220.87208874
46Collecting duct acid secretion_Homo sapiens_hsa049660.84172126
47Propanoate metabolism_Homo sapiens_hsa006400.81086968
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79435771
49Viral myocarditis_Homo sapiens_hsa054160.79262135
50Sulfur metabolism_Homo sapiens_hsa009200.78191758
51Peroxisome_Homo sapiens_hsa041460.74114327
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74090363
53Olfactory transduction_Homo sapiens_hsa047400.73197515
54Caffeine metabolism_Homo sapiens_hsa002320.66767773
55Metabolic pathways_Homo sapiens_hsa011000.64342670
56Arachidonic acid metabolism_Homo sapiens_hsa005900.63952469
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62528701
58Hematopoietic cell lineage_Homo sapiens_hsa046400.62112250
59Nitrogen metabolism_Homo sapiens_hsa009100.59254417
60Tryptophan metabolism_Homo sapiens_hsa003800.58571385
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.57885934
62Butanoate metabolism_Homo sapiens_hsa006500.51960654
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.51915818
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51624838
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51307649
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50706619
67Staphylococcus aureus infection_Homo sapiens_hsa051500.48958262
68Glutathione metabolism_Homo sapiens_hsa004800.48506680
69Nicotine addiction_Homo sapiens_hsa050330.48112795
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46749084
71Morphine addiction_Homo sapiens_hsa050320.46636471
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44754725
73Folate biosynthesis_Homo sapiens_hsa007900.44091417
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43997134
75Pyruvate metabolism_Homo sapiens_hsa006200.42703363
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41971195
77Fat digestion and absorption_Homo sapiens_hsa049750.41864608
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40896915
79Ether lipid metabolism_Homo sapiens_hsa005650.39672875
80Chemical carcinogenesis_Homo sapiens_hsa052040.39376477
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36607191
82Retinol metabolism_Homo sapiens_hsa008300.34023358
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32965097
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32953842
85Taste transduction_Homo sapiens_hsa047420.32621327
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30200275
87Leishmaniasis_Homo sapiens_hsa051400.28807072
88Selenocompound metabolism_Homo sapiens_hsa004500.27650581
89GABAergic synapse_Homo sapiens_hsa047270.27170164
90Fatty acid elongation_Homo sapiens_hsa000620.26502504
91Epstein-Barr virus infection_Homo sapiens_hsa051690.25679871
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.25662505
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.25280885
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.24123971
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22647185
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20198740
97Fatty acid degradation_Homo sapiens_hsa000710.19546059
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18418782
99beta-Alanine metabolism_Homo sapiens_hsa004100.18153742
100Arginine and proline metabolism_Homo sapiens_hsa003300.17809944

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