RPSAP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.18265486
2ribosomal small subunit biogenesis (GO:0042274)7.60334485
3viral transcription (GO:0019083)7.33551250
4translational termination (GO:0006415)7.10607212
5translational elongation (GO:0006414)6.16602729
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.96923286
7cotranslational protein targeting to membrane (GO:0006613)5.87364124
8behavioral response to nicotine (GO:0035095)5.84332192
9protein targeting to ER (GO:0045047)5.81500149
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.63819080
11protein localization to endoplasmic reticulum (GO:0070972)5.43193685
12cellular protein complex disassembly (GO:0043624)5.42398291
13ncRNA 3-end processing (GO:0043628)5.32338479
14viral life cycle (GO:0019058)5.27786303
15maturation of SSU-rRNA (GO:0030490)5.23479609
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.99272857
17protein complex disassembly (GO:0043241)4.62548126
18pyrimidine nucleoside salvage (GO:0043097)4.57743962
19pyrimidine-containing compound salvage (GO:0008655)4.57743962
20translational initiation (GO:0006413)4.43692306
21macromolecular complex disassembly (GO:0032984)4.43016204
22CTP metabolic process (GO:0046036)4.36562059
23CTP biosynthetic process (GO:0006241)4.36562059
24ATP synthesis coupled proton transport (GO:0015986)4.29115581
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29115581
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.28275766
27protein complex biogenesis (GO:0070271)4.25906696
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.25789061
29ribosomal large subunit biogenesis (GO:0042273)4.12930052
30nucleoside salvage (GO:0043174)4.10782839
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.04620465
32NADH dehydrogenase complex assembly (GO:0010257)4.04620465
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.04620465
34mitochondrial respiratory chain complex assembly (GO:0033108)4.01316128
35pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.93358391
36pyrimidine nucleobase catabolic process (GO:0006208)3.87974331
37chaperone-mediated protein transport (GO:0072321)3.85796085
38protein targeting to membrane (GO:0006612)3.83331826
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81265343
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.79308809
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.79308809
42pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.74717691
43translation (GO:0006412)3.62567062
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.60401812
45pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.42505383
46UMP metabolic process (GO:0046049)3.42505383
47pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.42505383
48UMP biosynthetic process (GO:0006222)3.42505383
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.41524465
50pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.34242582
51cell proliferation in forebrain (GO:0021846)3.33741449
52nucleotide salvage (GO:0043173)3.32854422
53respiratory electron transport chain (GO:0022904)3.31473606
54electron transport chain (GO:0022900)3.29841839
55respiratory chain complex IV assembly (GO:0008535)3.28734601
56cellular component biogenesis (GO:0044085)3.24754173
57terpenoid biosynthetic process (GO:0016114)3.22615200
58mRNA catabolic process (GO:0006402)3.19268088
59spinal cord association neuron differentiation (GO:0021527)3.19100143
60nucleobase catabolic process (GO:0046113)3.16090794
61ribonucleoprotein complex biogenesis (GO:0022613)3.15022879
62positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.03304152
63synaptic transmission, cholinergic (GO:0007271)2.98546922
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97834757
65intracellular protein transmembrane import (GO:0044743)2.97380474
66pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96649360
67DNA deamination (GO:0045006)2.94571993
68ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92462851
69pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.90325707
70protein neddylation (GO:0045116)2.88201630
71transmission of nerve impulse (GO:0019226)2.84675661
72pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83930941
73RNA catabolic process (GO:0006401)2.83475483
74cytochrome complex assembly (GO:0017004)2.81194284
75hydrogen ion transmembrane transport (GO:1902600)2.81040940
76somite development (GO:0061053)2.80441929
77GTP biosynthetic process (GO:0006183)2.79334921
78grooming behavior (GO:0007625)2.76504133
79negative regulation of response to food (GO:0032096)2.75518404
80negative regulation of appetite (GO:0032099)2.75518404
81kidney morphogenesis (GO:0060993)2.74035999
82pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.71238620
83protein import into peroxisome matrix (GO:0016558)2.69596156
84establishment of protein localization to membrane (GO:0090150)2.65373963
85tRNA processing (GO:0008033)2.62756392
86water-soluble vitamin biosynthetic process (GO:0042364)2.60793422
87epithelial cilium movement (GO:0003351)2.60273235
88RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.57020122
89regulation of glycogen (starch) synthase activity (GO:2000465)2.53000629
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52989754
91protein targeting (GO:0006605)2.52810642
92nonmotile primary cilium assembly (GO:0035058)2.52789100
93regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.51686291
94proton transport (GO:0015992)2.51504729
95neuron fate determination (GO:0048664)2.51176702
96central nervous system myelination (GO:0022010)2.48804377
97axon ensheathment in central nervous system (GO:0032291)2.48804377
98protein polyglutamylation (GO:0018095)2.46705342
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.46620660
100pyrimidine ribonucleotide metabolic process (GO:0009218)2.46492463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79563497
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.75202081
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.12884170
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12525931
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62762639
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62383837
7ZNF274_21170338_ChIP-Seq_K562_Hela2.56247070
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45139375
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35083189
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30207432
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.27772003
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.12852901
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11402771
14IGF1R_20145208_ChIP-Seq_DFB_Human2.09648103
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.09489778
16VDR_22108803_ChIP-Seq_LS180_Human2.07834557
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.00733066
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.99143457
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96507724
20IRF1_19129219_ChIP-ChIP_H3396_Human1.91755164
21REST_21632747_ChIP-Seq_MESCs_Mouse1.76195370
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.72499162
23RNF2_27304074_Chip-Seq_NSC_Mouse1.65098147
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59892043
25TAF15_26573619_Chip-Seq_HEK293_Human1.59338384
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56705176
27MYC_18940864_ChIP-ChIP_HL60_Human1.53674331
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51650407
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48967512
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45118288
31TP53_22573176_ChIP-Seq_HFKS_Human1.42987857
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42975530
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.42294193
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40429473
35EWS_26573619_Chip-Seq_HEK293_Human1.37629345
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36957985
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36015343
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35191279
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33363106
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33363106
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32521978
42ELK1_19687146_ChIP-ChIP_HELA_Human1.32421761
43FUS_26573619_Chip-Seq_HEK293_Human1.32077706
44NCOR_22424771_ChIP-Seq_293T_Human1.31687380
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.31366909
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30191412
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29045117
48ERA_21632823_ChIP-Seq_H3396_Human1.25519022
49BCAT_22108803_ChIP-Seq_LS180_Human1.23816326
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.23577868
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22997116
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18862934
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18596825
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18350704
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17408009
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16532270
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16280604
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15859890
59VDR_23849224_ChIP-Seq_CD4+_Human1.15473584
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15019187
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.14809912
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.14364589
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13606180
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09194735
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09194735
66P300_19829295_ChIP-Seq_ESCs_Human1.08117363
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07869493
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07712074
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07667584
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05658709
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05553853
72TTF2_22483619_ChIP-Seq_HELA_Human1.04956099
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04589175
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04253056
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04098093
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03309343
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01946838
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01343065
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.00480987
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99304724
81NANOG_20526341_ChIP-Seq_ESCs_Human0.98153046
82XRN2_22483619_ChIP-Seq_HELA_Human0.97698156
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95635195
84CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95590774
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95521711
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.95432572
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94664352
88FOXP3_21729870_ChIP-Seq_TREG_Human0.94032284
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.92431149
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92431149
91MYC_19829295_ChIP-Seq_ESCs_Human0.92375979
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91878338
93RING1B_27294783_Chip-Seq_ESCs_Mouse0.89676653
94HTT_18923047_ChIP-ChIP_STHdh_Human0.89240822
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88622551
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88059674
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.87953711
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86637595
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.85727757
100MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85100396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.54011524
2MP0003787_abnormal_imprinting3.81327254
3MP0009379_abnormal_foot_pigmentation3.71648904
4MP0002163_abnormal_gland_morphology3.05676702
5MP0003121_genomic_imprinting3.04937877
6MP0003122_maternal_imprinting2.74961472
7MP0008877_abnormal_DNA_methylation2.56080183
8MP0002638_abnormal_pupillary_reflex2.45752805
9MP0001873_stomach_inflammation2.31586481
10MP0005499_abnormal_olfactory_system2.27547494
11MP0005394_taste/olfaction_phenotype2.27547494
12MP0003011_delayed_dark_adaptation2.24399372
13MP0003646_muscle_fatigue2.22357550
14MP0003123_paternal_imprinting2.21140814
15MP0008789_abnormal_olfactory_epithelium2.15133447
16MP0002735_abnormal_chemical_nociception2.06933090
17MP0001348_abnormal_lacrimal_gland1.95974274
18MP0006276_abnormal_autonomic_nervous1.89254416
19MP0003879_abnormal_hair_cell1.82512654
20MP0005646_abnormal_pituitary_gland1.77157500
21MP0002653_abnormal_ependyma_morphology1.76404109
22MP0004133_heterotaxia1.75234149
23MP0005551_abnormal_eye_electrophysiolog1.74773720
24MP0006082_CNS_inflammation1.72580499
25MP0003880_abnormal_central_pattern1.71349506
26MP0002102_abnormal_ear_morphology1.66578743
27MP0004142_abnormal_muscle_tone1.66072575
28MP0004145_abnormal_muscle_electrophysio1.64040463
29MP0002837_dystrophic_cardiac_calcinosis1.61304264
30MP0008875_abnormal_xenobiotic_pharmacok1.60787344
31MP0001968_abnormal_touch/_nociception1.60731134
32MP0001440_abnormal_grooming_behavior1.59083594
33MP0005379_endocrine/exocrine_gland_phen1.58371178
34MP0004742_abnormal_vestibular_system1.48304058
35MP0002272_abnormal_nervous_system1.43894564
36MP0008872_abnormal_physiological_respon1.43759648
37MP0001970_abnormal_pain_threshold1.39054519
38MP0002736_abnormal_nociception_after1.38037818
39MP0004510_myositis1.36809115
40MP0000631_abnormal_neuroendocrine_gland1.36738777
41MP0002733_abnormal_thermal_nociception1.35159513
42MP0002938_white_spotting1.34459319
43MP0002234_abnormal_pharynx_morphology1.31144967
44MP0004885_abnormal_endolymph1.30488534
45MP0000778_abnormal_nervous_system1.30245898
46MP0005645_abnormal_hypothalamus_physiol1.29457801
47MP0009745_abnormal_behavioral_response1.29038000
48MP0001293_anophthalmia1.26104237
49MP0005084_abnormal_gallbladder_morpholo1.24761208
50MP0001905_abnormal_dopamine_level1.20912566
51MP0002557_abnormal_social/conspecific_i1.18857778
52MP0002160_abnormal_reproductive_system1.17171364
53MP0003136_yellow_coat_color1.16371201
54MP0006072_abnormal_retinal_apoptosis1.11063460
55MP0001727_abnormal_embryo_implantation1.10677727
56MP0002876_abnormal_thyroid_physiology1.09398408
57MP0001986_abnormal_taste_sensitivity1.07644230
58MP0002184_abnormal_innervation1.07560373
59MP0003195_calcinosis1.07073921
60MP0005389_reproductive_system_phenotype1.06211608
61MP0001485_abnormal_pinna_reflex1.05028524
62MP0005423_abnormal_somatic_nervous1.03706555
63MP0003635_abnormal_synaptic_transmissio1.02147111
64MP0002572_abnormal_emotion/affect_behav1.01940945
65MP0008995_early_reproductive_senescence1.01411109
66MP0000026_abnormal_inner_ear1.01269532
67MP0005075_abnormal_melanosome_morpholog1.00885976
68MP0002752_abnormal_somatic_nervous1.00439655
69MP0002095_abnormal_skin_pigmentation0.99267624
70MP0005195_abnormal_posterior_eye0.98182656
71MP0003938_abnormal_ear_development0.97358934
72MP0000049_abnormal_middle_ear0.96493978
73MP0001663_abnormal_digestive_system0.96304152
74MP0001919_abnormal_reproductive_system0.91623051
75MP0001529_abnormal_vocalization0.91285415
76MP0002734_abnormal_mechanical_nocicepti0.87375492
77MP0005377_hearing/vestibular/ear_phenot0.86016073
78MP0003878_abnormal_ear_physiology0.86016073
79MP0005253_abnormal_eye_physiology0.85604936
80MP0010386_abnormal_urinary_bladder0.84613860
81MP0002063_abnormal_learning/memory/cond0.84088661
82MP0000372_irregular_coat_pigmentation0.83024237
83MP0002822_catalepsy0.82194287
84MP0002064_seizures0.81549286
85MP0001963_abnormal_hearing_physiology0.79051755
86MP0001486_abnormal_startle_reflex0.78249719
87MP0003119_abnormal_digestive_system0.76921452
88MP0002067_abnormal_sensory_capabilities0.75673038
89MP0001502_abnormal_circadian_rhythm0.75341325
90MP0005448_abnormal_energy_balance0.70958547
91MP0002277_abnormal_respiratory_mucosa0.70197030
92MP0002210_abnormal_sex_determination0.70120059
93MP0003567_abnormal_fetal_cardiomyocyte0.70081102
94MP0000955_abnormal_spinal_cord0.69274174
95MP0002882_abnormal_neuron_morphology0.68653069
96MP0009046_muscle_twitch0.68478070
97MP0003186_abnormal_redox_activity0.67320927
98MP0001984_abnormal_olfaction0.66143207
99MP0003942_abnormal_urinary_system0.66074839
100MP0001286_abnormal_eye_development0.65921338

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.32835517
2Abnormality of cells of the erythroid lineage (HP:0012130)4.21163004
3Abnormal number of erythroid precursors (HP:0012131)3.69286455
4Acute necrotizing encephalopathy (HP:0006965)3.62379653
5Asplenia (HP:0001746)3.61690245
6Abnormality of macular pigmentation (HP:0008002)3.54724112
7Aplasia/Hypoplasia of the spleen (HP:0010451)3.53962126
8Lipid accumulation in hepatocytes (HP:0006561)3.40104852
9Constricted visual fields (HP:0001133)3.39842178
10Mitochondrial inheritance (HP:0001427)3.27457012
11Abnormal mitochondria in muscle tissue (HP:0008316)3.18342681
12Increased hepatocellular lipid droplets (HP:0006565)3.17524419
13Pancreatic fibrosis (HP:0100732)3.13152306
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11980489
15Acute encephalopathy (HP:0006846)3.08476645
16Abnormality of the labia minora (HP:0012880)3.07796556
17Progressive macrocephaly (HP:0004481)2.96390182
18Macrocytic anemia (HP:0001972)2.91424268
19Increased CSF lactate (HP:0002490)2.90736984
20Volvulus (HP:0002580)2.89252449
21Renal Fanconi syndrome (HP:0001994)2.89040272
22Hyperglycinemia (HP:0002154)2.85040203
23Supernumerary spleens (HP:0009799)2.80045071
24Optic disc pallor (HP:0000543)2.77954253
25Congenital stationary night blindness (HP:0007642)2.73073798
26Molar tooth sign on MRI (HP:0002419)2.72591234
27Abnormality of midbrain morphology (HP:0002418)2.72591234
28Nephronophthisis (HP:0000090)2.70326222
29Attenuation of retinal blood vessels (HP:0007843)2.69143001
30Pancreatic cysts (HP:0001737)2.67157530
31Medial flaring of the eyebrow (HP:0010747)2.65883315
32Abnormal rod and cone electroretinograms (HP:0008323)2.64161992
33Hepatocellular necrosis (HP:0001404)2.62775028
34Pendular nystagmus (HP:0012043)2.62263420
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60808139
36Septo-optic dysplasia (HP:0100842)2.59165140
37Hip dysplasia (HP:0001385)2.44619629
38True hermaphroditism (HP:0010459)2.44269902
39Abnormality of the renal medulla (HP:0100957)2.41347617
40Decreased muscle mass (HP:0003199)2.38979444
41Hypoplasia of the pons (HP:0012110)2.35169221
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34665327
43Cerebral edema (HP:0002181)2.34476255
44Poor suck (HP:0002033)2.34380718
45Colon cancer (HP:0003003)2.32541485
46Pallor (HP:0000980)2.30612022
47Cone-rod dystrophy (HP:0000548)2.26799696
48Hepatic necrosis (HP:0002605)2.26577781
49Abnormality of renal resorption (HP:0011038)2.25216093
50Striae distensae (HP:0001065)2.24050367
51Abnormal drinking behavior (HP:0030082)2.23748699
52Polydipsia (HP:0001959)2.23748699
53Parakeratosis (HP:0001036)2.17913357
54Gait imbalance (HP:0002141)2.16486486
55Myokymia (HP:0002411)2.15431769
56Adrenal hypoplasia (HP:0000835)2.14876053
57Abnormality of the pons (HP:0007361)2.14419798
58Absent thumb (HP:0009777)2.12132516
59Metaphyseal cupping (HP:0003021)2.10583637
603-Methylglutaconic aciduria (HP:0003535)2.10033402
61Increased intramyocellular lipid droplets (HP:0012240)2.08558691
62Hyperthyroidism (HP:0000836)2.08330015
63Congenital, generalized hypertrichosis (HP:0004540)2.07940913
64Anomalous pulmonary venous return (HP:0010772)2.06831862
65Agitation (HP:0000713)2.03977581
66Tubular atrophy (HP:0000092)2.02700210
67Dyskinesia (HP:0100660)1.99378490
68Congenital primary aphakia (HP:0007707)1.98685886
69Abnormality of the metopic suture (HP:0005556)1.97466146
70Polyuria (HP:0000103)1.97234738
71Concave nail (HP:0001598)1.96280351
72Increased muscle lipid content (HP:0009058)1.95908555
73Enlarged kidneys (HP:0000105)1.94916787
74Nephrogenic diabetes insipidus (HP:0009806)1.94291753
75Increased serum lactate (HP:0002151)1.91480916
76Hip contracture (HP:0003273)1.89761351
77Abnormal biliary tract physiology (HP:0012439)1.89741914
78Bile duct proliferation (HP:0001408)1.89741914
79Round ear (HP:0100830)1.88301611
80Small hand (HP:0200055)1.87298027
81Abnormality of the renal cortex (HP:0011035)1.86640507
82Exertional dyspnea (HP:0002875)1.86282976
83Anencephaly (HP:0002323)1.81530262
84Abnormality of the pulmonary veins (HP:0011718)1.78991644
85Prominent metopic ridge (HP:0005487)1.78932227
86Sclerocornea (HP:0000647)1.77302351
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75216806
88Decreased central vision (HP:0007663)1.75175445
89Retinitis pigmentosa (HP:0000510)1.72553108
90Exercise intolerance (HP:0003546)1.71687680
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71232911
92Male pseudohermaphroditism (HP:0000037)1.71087655
93Abnormality of serine family amino acid metabolism (HP:0010894)1.70537534
94Abnormality of glycine metabolism (HP:0010895)1.70537534
95Lactic acidosis (HP:0003128)1.70522910
96Tubulointerstitial fibrosis (HP:0005576)1.70285750
97Abnormal respiratory motile cilium physiology (HP:0012261)1.69555990
98Hyperphosphatemia (HP:0002905)1.67150420
99Abnormal ciliary motility (HP:0012262)1.66878898
100Abnormality of DNA repair (HP:0003254)1.66756681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.07941405
2BMPR1B2.69067763
3KIT2.51614924
4WNK42.42412685
5ADRBK22.41157814
6BCKDK2.40661203
7FRK2.38106863
8LIMK12.34337374
9DYRK22.28518024
10ZAK2.04407744
11GRK11.89673704
12CASK1.87129514
13NUAK11.77379097
14CDK191.72631784
15PINK11.67389951
16VRK21.59383598
17TNIK1.57329105
18WNK31.56992403
19TEC1.56527208
20STK161.50246600
21PRKCG1.48510389
22STK241.45082427
23FES1.43555090
24TXK1.43334998
25TYRO31.41747797
26PIK3CA1.40283857
27TAOK31.33430735
28STK391.26643076
29NTRK21.26188145
30MARK11.22002664
31PLK21.18888339
32MKNK21.15530952
33MAP2K71.14291672
34VRK11.14239078
35NME11.13696961
36MAP4K11.12045487
37MINK11.08714548
38SIK21.08111289
39CDC71.07048523
40TIE11.06001876
41MAP3K41.04852535
42PAK31.04112768
43PASK0.96004624
44LRRK20.95801016
45PRKCQ0.94982878
46ADRBK10.94083608
47IKBKB0.90213196
48INSRR0.87275385
49PDK20.87122096
50TLK10.84053392
51MAP2K60.83116619
52NLK0.82318522
53ABL20.81807028
54OXSR10.81283335
55DAPK20.79608762
56CAMKK20.79531631
57PRKACA0.78786861
58DYRK30.76710527
59CSNK2A20.76005991
60PHKG20.75780793
61PHKG10.75780793
62STK110.74383886
63DYRK1A0.69886520
64PLK10.68760110
65TGFBR10.67549914
66TRIM280.67311106
67TAF10.66573622
68SGK2230.65658171
69SGK4940.65658171
70RPS6KA50.64936859
71MKNK10.64716524
72PLK30.63786295
73EPHA40.62924457
74SGK20.62807571
75AURKA0.62326271
76RPS6KA60.61884989
77CSNK1A10.60799907
78BCR0.60394976
79OBSCN0.57924113
80PRKCA0.57393492
81ITK0.56948406
82CAMK10.56890175
83PRKCE0.56534422
84DAPK30.56370405
85CAMKK10.55537470
86CSNK2A10.55481576
87CSK0.54402186
88CSNK1E0.53356815
89CAMK2A0.53277191
90CSNK1G10.52814649
91MAPK130.52085859
92PRKCI0.48524779
93PKN10.46950376
94SYK0.42811511
95RPS6KL10.42502153
96RPS6KC10.42502153
97MAPK150.42070516
98CSNK1G20.41775148
99BTK0.41532469
100CDK50.41142264

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.19516432
2Oxidative phosphorylation_Homo sapiens_hsa001904.19132693
3Parkinsons disease_Homo sapiens_hsa050123.46967846
4Sulfur relay system_Homo sapiens_hsa041222.56800071
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48355808
6Huntingtons disease_Homo sapiens_hsa050162.42013282
7Cardiac muscle contraction_Homo sapiens_hsa042602.39135573
8Alzheimers disease_Homo sapiens_hsa050102.38349443
9Phototransduction_Homo sapiens_hsa047442.31144052
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30016785
11Protein export_Homo sapiens_hsa030602.15567911
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99877412
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83076713
14Proteasome_Homo sapiens_hsa030501.79345128
15Nicotine addiction_Homo sapiens_hsa050331.62115808
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58809016
17RNA polymerase_Homo sapiens_hsa030201.52199674
18Linoleic acid metabolism_Homo sapiens_hsa005911.44640199
19Butanoate metabolism_Homo sapiens_hsa006501.43561171
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.40172136
21Pyrimidine metabolism_Homo sapiens_hsa002401.33158676
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31607605
23Peroxisome_Homo sapiens_hsa041461.26797154
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24477443
25Tryptophan metabolism_Homo sapiens_hsa003801.22270658
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20874801
27Steroid biosynthesis_Homo sapiens_hsa001001.20503772
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17451583
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14567124
30Asthma_Homo sapiens_hsa053101.09801097
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09479602
32Olfactory transduction_Homo sapiens_hsa047401.06210538
33Nitrogen metabolism_Homo sapiens_hsa009101.03958624
34Glycerolipid metabolism_Homo sapiens_hsa005611.03837284
35One carbon pool by folate_Homo sapiens_hsa006701.01022813
36beta-Alanine metabolism_Homo sapiens_hsa004101.00745468
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00697867
38Propanoate metabolism_Homo sapiens_hsa006400.99009734
39RNA degradation_Homo sapiens_hsa030180.97492076
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.92255878
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.91835936
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.90764260
43Basal transcription factors_Homo sapiens_hsa030220.89222594
44Primary immunodeficiency_Homo sapiens_hsa053400.88123193
45Arginine and proline metabolism_Homo sapiens_hsa003300.84800211
46Allograft rejection_Homo sapiens_hsa053300.80392718
47Arachidonic acid metabolism_Homo sapiens_hsa005900.78636464
48Fat digestion and absorption_Homo sapiens_hsa049750.78345307
49Morphine addiction_Homo sapiens_hsa050320.77137016
50Metabolic pathways_Homo sapiens_hsa011000.77008908
51Basal cell carcinoma_Homo sapiens_hsa052170.76675652
52Pyruvate metabolism_Homo sapiens_hsa006200.76523863
53Autoimmune thyroid disease_Homo sapiens_hsa053200.75247692
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.74277782
55Ether lipid metabolism_Homo sapiens_hsa005650.73712024
56Hematopoietic cell lineage_Homo sapiens_hsa046400.72290801
57Ovarian steroidogenesis_Homo sapiens_hsa049130.71719741
58Purine metabolism_Homo sapiens_hsa002300.70420297
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68739774
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68588102
61Type I diabetes mellitus_Homo sapiens_hsa049400.68390800
62Fanconi anemia pathway_Homo sapiens_hsa034600.67920039
63Homologous recombination_Homo sapiens_hsa034400.67642999
64Retinol metabolism_Homo sapiens_hsa008300.67560133
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66312739
66Chemical carcinogenesis_Homo sapiens_hsa052040.65282274
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63687280
68Insulin secretion_Homo sapiens_hsa049110.63064915
69Fatty acid degradation_Homo sapiens_hsa000710.62830811
70Taste transduction_Homo sapiens_hsa047420.62613151
71Serotonergic synapse_Homo sapiens_hsa047260.62600734
72DNA replication_Homo sapiens_hsa030300.62460732
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60660778
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59518605
75Hedgehog signaling pathway_Homo sapiens_hsa043400.59006130
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56911150
77Base excision repair_Homo sapiens_hsa034100.56573095
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56067084
79GABAergic synapse_Homo sapiens_hsa047270.54628175
80Sulfur metabolism_Homo sapiens_hsa009200.52605023
81Caffeine metabolism_Homo sapiens_hsa002320.51850511
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.50626242
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49096350
84Glutamatergic synapse_Homo sapiens_hsa047240.45793099
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45613795
86Starch and sucrose metabolism_Homo sapiens_hsa005000.45327419
87Mineral absorption_Homo sapiens_hsa049780.44078357
88Mismatch repair_Homo sapiens_hsa034300.42619701
89Selenocompound metabolism_Homo sapiens_hsa004500.40956929
90Nucleotide excision repair_Homo sapiens_hsa034200.40892049
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37079122
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37041154
93Cocaine addiction_Homo sapiens_hsa050300.36696918
94Graft-versus-host disease_Homo sapiens_hsa053320.34286345
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31854578
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.31561570
97Fatty acid biosynthesis_Homo sapiens_hsa000610.31537947
98Collecting duct acid secretion_Homo sapiens_hsa049660.30152032
99Histidine metabolism_Homo sapiens_hsa003400.29863072
100Dopaminergic synapse_Homo sapiens_hsa047280.29241135

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