ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.49134807
2	DNA deamination (GO:0045006)	5.91700181
3	viral transcription (GO:0019083)	5.69802496
4	translational termination (GO:0006415)	5.48268821
5	translational elongation (GO:0006414)	4.90117778
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.74057112
7	maturation of SSU-rRNA (GO:0030490)	4.68507537
8	cotranslational protein targeting to membrane (GO:0006613)	4.67589259
9	protein targeting to ER (GO:0045047)	4.66092652
10	chaperone-mediated protein transport (GO:0072321)	4.56359013
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.43521377
12	protein localization to endoplasmic reticulum (GO:0070972)	4.42458103
13	ribosomal small subunit biogenesis (GO:0042274)	4.41325857
14	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.40656169
15	ribosomal large subunit biogenesis (GO:0042273)	4.31049263
16	ATP synthesis coupled proton transport (GO:0015986)	4.28077713
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28077713
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.21417409
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.19469205
20	NADH dehydrogenase complex assembly (GO:0010257)	4.19260688
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.19260688
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.19260688
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.14669948
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.14669948
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.10769491
26	cellular protein complex disassembly (GO:0043624)	4.08488167
27	pseudouridine synthesis (GO:0001522)	4.07499449
28	translational initiation (GO:0006413)	4.06080334
29	viral life cycle (GO:0019058)	4.03054913
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91381545
31	protein complex biogenesis (GO:0070271)	3.90153176
32	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.84815575
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56472122
34	translation (GO:0006412)	3.53176451
35	cytidine catabolic process (GO:0006216)	3.51954457
36	cytidine deamination (GO:0009972)	3.51954457
37	cytidine metabolic process (GO:0046087)	3.51954457
38	pyrimidine nucleotide catabolic process (GO:0006244)	3.49638168
39	purine nucleotide salvage (GO:0032261)	3.48975297
40	rRNA transcription (GO:0009303)	3.46905157
41	respiratory electron transport chain (GO:0022904)	3.41949668
42	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.41805361
43	termination of RNA polymerase III transcription (GO:0006386)	3.41805361
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.41040843
45	electron transport chain (GO:0022900)	3.40736581
46	positive regulation of defense response to virus by host (GO:0002230)	3.39327537
47	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.38584454
48	protein complex disassembly (GO:0043241)	3.35414979
49	ncRNA 3-end processing (GO:0043628)	3.32253953
50	cellular component biogenesis (GO:0044085)	3.31136723
51	leukocyte aggregation (GO:0070486)	3.28591757
52	macromolecular complex disassembly (GO:0032984)	3.21515123
53	ribonucleoprotein complex biogenesis (GO:0022613)	3.14998648
54	iron-sulfur cluster assembly (GO:0016226)	3.13498465
55	metallo-sulfur cluster assembly (GO:0031163)	3.13498465
56	GTP biosynthetic process (GO:0006183)	3.10750392
57	response to pheromone (GO:0019236)	3.06367190
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.05868066
59	rRNA modification (GO:0000154)	3.03006175
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02844673
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99125700
62	aggressive behavior (GO:0002118)	2.98879786
63	rRNA metabolic process (GO:0016072)	2.97250480
64	transcription from mitochondrial promoter (GO:0006390)	2.97158904
65	base-excision repair, AP site formation (GO:0006285)	2.94301089
66	protein targeting to membrane (GO:0006612)	2.93328656
67	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.89698968
68	forebrain morphogenesis (GO:0048853)	2.88428876
69	positive regulation of prostaglandin secretion (GO:0032308)	2.85976799
70	mRNA catabolic process (GO:0006402)	2.85857062
71	deoxyribonucleotide catabolic process (GO:0009264)	2.85732340
72	proteasome assembly (GO:0043248)	2.85091399
73	male meiosis I (GO:0007141)	2.83013722
74	positive regulation of B cell differentiation (GO:0045579)	2.81071347
75	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.78908427
76	rRNA processing (GO:0006364)	2.78592999
77	intracellular protein transmembrane import (GO:0044743)	2.77910525
78	UTP biosynthetic process (GO:0006228)	2.75674210
79	protein targeting to mitochondrion (GO:0006626)	2.74999086
80	aldehyde catabolic process (GO:0046185)	2.74539192
81	protein neddylation (GO:0045116)	2.72836804
82	deoxyribose phosphate catabolic process (GO:0046386)	2.71895892
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.71453826
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.69224893
85	UTP metabolic process (GO:0046051)	2.69201566
86	grooming behavior (GO:0007625)	2.67910677
87	behavioral response to nicotine (GO:0035095)	2.63865296
88	RNA catabolic process (GO:0006401)	2.60864465
89	GMP metabolic process (GO:0046037)	2.58456767
90	establishment of protein localization to mitochondrion (GO:0072655)	2.57453397
91	purine-containing compound salvage (GO:0043101)	2.57370516
92	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.56576866
93	ATP biosynthetic process (GO:0006754)	2.56111577
94	guanosine-containing compound biosynthetic process (GO:1901070)	2.55446329
95	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.54492306
96	activation of MAPKKK activity (GO:0000185)	2.54173689
97	peptidyl-histidine modification (GO:0018202)	2.53550536
98	tRNA processing (GO:0008033)	2.51051609
99	ubiquinone biosynthetic process (GO:0006744)	2.50862922
100	protein-cofactor linkage (GO:0018065)	2.49947519

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90816065
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58760217
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.44657604
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23403310
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04381435
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.00167707
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.94369777
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.83573875
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75815697
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72193892
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.44273704
12	VDR_22108803_ChIP-Seq_LS180_Human	2.41210251
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.39359305
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.36124622
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30443359
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.28713313
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25652812
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.23497040
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.20281794
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.03910914
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90711820
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90121189
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86577909
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.82560019
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.79895223
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79135212
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77166740
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.75317666
29	EWS_26573619_Chip-Seq_HEK293_Human	1.74466175
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.70939204
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67544701
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.66332324
33	FUS_26573619_Chip-Seq_HEK293_Human	1.63336181
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63070629
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.57135529
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.54072331
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.53977190
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53254869
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.46000108
40	NCOR_22424771_ChIP-Seq_293T_Human	1.43454301
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42691536
42	AR_20517297_ChIP-Seq_VCAP_Human	1.42347715
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.40820770
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40482994
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40482994
46	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.32032143
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.29942950
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28955162
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28847594
50	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.27581277
51	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.27502690
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27173669
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25851089
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23672331
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22434163
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21590407
57	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21430968
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.21411208
59	EZH2_22144423_ChIP-Seq_EOC_Human	1.21245126
60	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.20714369
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18909495
62	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.15088295
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14954288
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14705302
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13180351
66	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.12631204
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11142649
68	MYB_26560356_Chip-Seq_TH2_Human	1.10525133
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09026944
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.08990605
71	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08936295
72	STAT1_20625510_ChIP-Seq_HELA_Human	1.07791520
73	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05101977
74	GATA3_26560356_Chip-Seq_TH2_Human	1.04234680
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03554529
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03441523
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02973085
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02973085
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01835726
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00557962
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00265033
82	ERG_20517297_ChIP-Seq_VCAP_Human	0.98728888
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98425737
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97597695
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97019584
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96401931
87	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.96227381
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95388186
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.95056036
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93965569
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92151702
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92051610
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91400856
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.90353904
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90335582
96	ERA_21632823_ChIP-Seq_H3396_Human	0.90320809
97	DCP1A_22483619_ChIP-Seq_HELA_Human	0.90103651
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89911929
99	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89452738
100	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88399946

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.02490325
2	MP0006292_abnormal_olfactory_placode	3.53746773
3	MP0005671_abnormal_response_to	3.35171088
4	MP0000013_abnormal_adipose_tissue	2.49637006
5	MP0002138_abnormal_hepatobiliary_system	2.48223750
6	MP0005623_abnormal_meninges_morphology	2.37338088
7	MP0005646_abnormal_pituitary_gland	2.37285877
8	MP0005084_abnormal_gallbladder_morpholo	2.16613324
9	MP0001873_stomach_inflammation	2.15206047
10	MP0002132_abnormal_respiratory_system	2.09435503
11	MP0005551_abnormal_eye_electrophysiolog	2.09084740
12	MP0001835_abnormal_antigen_presentation	2.01871311
13	MP0002163_abnormal_gland_morphology	1.95181346
14	MP0004147_increased_porphyrin_level	1.94601371
15	MP0003786_premature_aging	1.91747634
16	MP0009333_abnormal_splenocyte_physiolog	1.80900043
17	MP0002837_dystrophic_cardiac_calcinosis	1.78373317
18	MP0006072_abnormal_retinal_apoptosis	1.71979661
19	MP0002160_abnormal_reproductive_system	1.68827660
20	MP0003806_abnormal_nucleotide_metabolis	1.60622186
21	MP0000372_irregular_coat_pigmentation	1.60204805
22	MP0001968_abnormal_touch/_nociception	1.56052507
23	MP0003763_abnormal_thymus_physiology	1.53764165
24	MP0009785_altered_susceptibility_to	1.53105677
25	MP0008872_abnormal_physiological_respon	1.51798417
26	MP0004142_abnormal_muscle_tone	1.49981962
27	MP0001764_abnormal_homeostasis	1.48979233
28	MP0003567_abnormal_fetal_cardiomyocyte	1.48975840
29	MP0009384_cardiac_valve_regurgitation	1.48066365
30	MP0004145_abnormal_muscle_electrophysio	1.47725038
31	MP0002102_abnormal_ear_morphology	1.47077369
32	MP0002938_white_spotting	1.46741565
33	MP0008058_abnormal_DNA_repair	1.40510120
34	MP0005379_endocrine/exocrine_gland_phen	1.40400655
35	MP0005389_reproductive_system_phenotype	1.40182403
36	MP0000678_abnormal_parathyroid_gland	1.39893783
37	MP0002638_abnormal_pupillary_reflex	1.35707359
38	MP0001800_abnormal_humoral_immune	1.35594300
39	MP0001905_abnormal_dopamine_level	1.32790693
40	MP0002653_abnormal_ependyma_morphology	1.30649343
41	MP0002148_abnormal_hypersensitivity_rea	1.29532058
42	MP0008875_abnormal_xenobiotic_pharmacok	1.28861563
43	MP0003186_abnormal_redox_activity	1.25857113
44	MP0006276_abnormal_autonomic_nervous	1.25412670
45	MP0005645_abnormal_hypothalamus_physiol	1.24719185
46	MP0008877_abnormal_DNA_methylation	1.23688100
47	MP0006036_abnormal_mitochondrial_physio	1.23594210
48	MP0005410_abnormal_fertilization	1.20717482
49	MP0002736_abnormal_nociception_after	1.20286170
50	MP0002234_abnormal_pharynx_morphology	1.16070377
51	MP0000631_abnormal_neuroendocrine_gland	1.15222788
52	MP0005075_abnormal_melanosome_morpholog	1.14684586
53	MP0001790_abnormal_immune_system	1.14293373
54	MP0005387_immune_system_phenotype	1.14293373
55	MP0000049_abnormal_middle_ear	1.11543336
56	MP0004885_abnormal_endolymph	1.11113291
57	MP0008995_early_reproductive_senescence	1.10802731
58	MP0002876_abnormal_thyroid_physiology	1.03964543
59	MP0005253_abnormal_eye_physiology	1.03669018
60	MP0002420_abnormal_adaptive_immunity	1.02849799
61	MP0002095_abnormal_skin_pigmentation	1.02453389
62	MP0005000_abnormal_immune_tolerance	1.01032262
63	MP0002277_abnormal_respiratory_mucosa	1.00921800
64	MP0001188_hyperpigmentation	1.00509231
65	MP0002006_tumorigenesis	0.99950022
66	MP0001819_abnormal_immune_cell	0.99133533
67	MP0002723_abnormal_immune_serum	0.98641704
68	MP0009764_decreased_sensitivity_to	0.95015853
69	MP0003718_maternal_effect	0.93676084
70	MP0002166_altered_tumor_susceptibility	0.89142564
71	MP0003011_delayed_dark_adaptation	0.89133978
72	MP0001529_abnormal_vocalization	0.88961596
73	MP0000689_abnormal_spleen_morphology	0.86674158
74	MP0003646_muscle_fatigue	0.86305648
75	MP0005332_abnormal_amino_acid	0.86166000
76	MP0002398_abnormal_bone_marrow	0.85778270
77	MP0009697_abnormal_copulation	0.85701687
78	MP0002452_abnormal_antigen_presenting	0.83008337
79	MP0001986_abnormal_taste_sensitivity	0.82991690
80	MP0000716_abnormal_immune_system	0.82857288
81	MP0002822_catalepsy	0.82198068
82	MP0000681_abnormal_thyroid_gland	0.79123166
83	MP0003137_abnormal_impulse_conducting	0.78526172
84	MP0005025_abnormal_response_to	0.78049162
85	MP0005464_abnormal_platelet_physiology	0.76069726
86	MP0002210_abnormal_sex_determination	0.75909007
87	MP0001485_abnormal_pinna_reflex	0.75495076
88	MP0002272_abnormal_nervous_system	0.74945357
89	MP0002405_respiratory_system_inflammati	0.74082327
90	MP0001661_extended_life_span	0.73752746
91	MP0008789_abnormal_olfactory_epithelium	0.72619244
92	MP0009250_abnormal_appendicular_skeleto	0.72533450
93	MP0002722_abnormal_immune_system	0.71751164
94	MP0002735_abnormal_chemical_nociception	0.71654950
95	MP0002928_abnormal_bile_duct	0.71325081
96	MP0006035_abnormal_mitochondrial_morpho	0.71114742
97	MP0001929_abnormal_gametogenesis	0.71007081
98	MP0003252_abnormal_bile_duct	0.70954714
99	MP0001663_abnormal_digestive_system	0.68464517
100	MP0000703_abnormal_thymus_morphology	0.68277253

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.08288119
2	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.84779155
3	Cerebellar dysplasia (HP:0007033)	4.67055041
4	Retinal dysplasia (HP:0007973)	4.42394262
5	Acute necrotizing encephalopathy (HP:0006965)	4.08730595
6	Abolished electroretinogram (ERG) (HP:0000550)	4.02559229
7	Hypoplasia of the pons (HP:0012110)	3.81035478
8	Mitochondrial inheritance (HP:0001427)	3.78026533
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.63395487
10	Abnormality of the pons (HP:0007361)	3.62359183
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.58541914
12	Acute encephalopathy (HP:0006846)	3.54522281
13	Retinal atrophy (HP:0001105)	3.42848861
14	Increased CSF lactate (HP:0002490)	3.37279476
15	Progressive macrocephaly (HP:0004481)	3.33094132
16	Abnormality of midbrain morphology (HP:0002418)	3.29798866
17	Molar tooth sign on MRI (HP:0002419)	3.29798866
18	Renal Fanconi syndrome (HP:0001994)	3.26007248
19	Pancreatic cysts (HP:0001737)	3.13549601
20	Hepatocellular necrosis (HP:0001404)	3.13270430
21	Lipid accumulation in hepatocytes (HP:0006561)	3.12448577
22	Increased hepatocellular lipid droplets (HP:0006565)	3.08061434
23	True hermaphroditism (HP:0010459)	3.06549020
24	Reticulocytopenia (HP:0001896)	2.95306617
25	Hepatic necrosis (HP:0002605)	2.91323275
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.86856024
27	Congenital stationary night blindness (HP:0007642)	2.85538217
28	Pancreatic fibrosis (HP:0100732)	2.83863291
29	Pallor (HP:0000980)	2.83264254
30	Aplastic anemia (HP:0001915)	2.83138191
31	Cerebral edema (HP:0002181)	2.83006428
32	IgG deficiency (HP:0004315)	2.80450540
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.77627228
34	Increased intramyocellular lipid droplets (HP:0012240)	2.63264155
35	Panhypogammaglobulinemia (HP:0003139)	2.62562513
36	Optic disc pallor (HP:0000543)	2.59784805
37	Constricted visual fields (HP:0001133)	2.58449742
38	Abnormality of DNA repair (HP:0003254)	2.58031518
39	Fatigue (HP:0012378)	2.54235408
40	Elevated erythrocyte sedimentation rate (HP:0003565)	2.51564529
41	B lymphocytopenia (HP:0010976)	2.45283460
42	3-Methylglutaconic aciduria (HP:0003535)	2.44803556
43	Increased IgM level (HP:0003496)	2.44425380
44	Abnormality of B cell number (HP:0010975)	2.44217666
45	Abnormal number of erythroid precursors (HP:0012131)	2.43890898
46	Increased serum lactate (HP:0002151)	2.42985861
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41474321
48	Abnormality of alanine metabolism (HP:0010916)	2.41474321
49	Hyperalaninemia (HP:0003348)	2.41474321
50	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.38878871
51	Increased muscle lipid content (HP:0009058)	2.33286970
52	Severe combined immunodeficiency (HP:0004430)	2.33236613
53	Nephronophthisis (HP:0000090)	2.31932981
54	Generalized aminoaciduria (HP:0002909)	2.30397970
55	Attenuation of retinal blood vessels (HP:0007843)	2.29949265
56	Stenosis of the external auditory canal (HP:0000402)	2.29864734
57	Lactic acidosis (HP:0003128)	2.28303144
58	Macrocytic anemia (HP:0001972)	2.23874444
59	Asplenia (HP:0001746)	2.21671679
60	Abnormality of urine glucose concentration (HP:0011016)	2.20445370
61	Glycosuria (HP:0003076)	2.20445370
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18270218
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14111109
64	Abnormality of renal resorption (HP:0011038)	2.11847547
65	Hypoproteinemia (HP:0003075)	2.10673584
66	Absent/shortened dynein arms (HP:0200106)	2.08519053
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08519053
68	Respiratory failure (HP:0002878)	2.08111455
69	Pancytopenia (HP:0001876)	2.03449298
70	Encephalitis (HP:0002383)	2.03273656
71	Lethargy (HP:0001254)	2.02589874
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02200790
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02200790
74	Hyperglycinemia (HP:0002154)	1.99610163
75	Severe muscular hypotonia (HP:0006829)	1.96451726
76	Colon cancer (HP:0003003)	1.95737601
77	Entropion (HP:0000621)	1.94618354
78	Decreased central vision (HP:0007663)	1.94490864
79	Exertional dyspnea (HP:0002875)	1.94264636
80	Hypoplasia of the uterus (HP:0000013)	1.92349348
81	Abnormality of the renal collecting system (HP:0004742)	1.92145667
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.92143703
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92143703
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91126156
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91039429
86	Poikiloderma (HP:0001029)	1.89587396
87	Abnormality of the prostate (HP:0008775)	1.89554479
88	Agammaglobulinemia (HP:0004432)	1.89488888
89	Medial flaring of the eyebrow (HP:0010747)	1.88674859
90	Cystic liver disease (HP:0006706)	1.88453596
91	Abnormality of eosinophils (HP:0001879)	1.88250848
92	Respiratory difficulties (HP:0002880)	1.83582978
93	Sclerocornea (HP:0000647)	1.82764581
94	Eosinophilia (HP:0001880)	1.80544157
95	Absent thumb (HP:0009777)	1.79836134
96	Severe global developmental delay (HP:0011344)	1.78473408
97	Exercise intolerance (HP:0003546)	1.77746281
98	T lymphocytopenia (HP:0005403)	1.77624766
99	Abnormal drinking behavior (HP:0030082)	1.77490758
100	Polydipsia (HP:0001959)	1.77490758

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.58910778
2	TXK	3.24018475
3	VRK2	2.80180490
4	TLK1	2.78233459
5	ZAK	2.75695310
6	BCKDK	2.74781761
7	MAP4K2	2.49516090
8	ADRBK2	2.44929496
9	KDR	2.38097198
10	GRK1	2.36855361
11	NUAK1	2.33467246
12	MARK3	2.31329239
13	VRK1	2.24706999
14	TAOK3	2.23197169
15	BMPR1B	2.17480647
16	STK10	1.92602224
17	MAP4K1	1.92567350
18	STK16	1.86906453
19	TESK2	1.68067332
20	KIT	1.62638429
21	TIE1	1.52141440
22	NME2	1.43812333
23	TEC	1.42264127
24	SCYL2	1.37172015
25	PIM1	1.37127039
26	PBK	1.32257687
27	SYK	1.23542714
28	FLT3	1.22267436
29	DYRK2	1.17471150
30	PRKCQ	1.15324978
31	WNK4	1.11557314
32	ITK	1.10116066
33	CSF1R	0.97853986
34	PINK1	0.96130434
35	TAF1	0.95523250
36	EIF2AK3	0.93553653
37	MAP2K7	0.90453541
38	TNK2	0.88540920
39	CSNK1G1	0.88071784
40	PASK	0.86828248
41	PRKG2	0.84774104
42	IKBKB	0.84447703
43	FRK	0.83725186
44	PLK4	0.83423014
45	BUB1	0.82859180
46	CAMKK2	0.82298933
47	RPS6KA4	0.81914239
48	CSNK1G3	0.80380053
49	PRKCH	0.78815125
50	CDK8	0.77761019
51	RPS6KA5	0.77196118
52	IKBKE	0.75979873
53	MST4	0.72693681
54	INSRR	0.72297840
55	MAP3K11	0.72143851
56	STK11	0.69035764
57	TGFBR1	0.68966318
58	WNK3	0.68083663
59	LCK	0.65488220
60	CSNK1G2	0.62037203
61	PIK3CG	0.61282356
62	PRKCE	0.61180988
63	RPS6KB2	0.60922002
64	LMTK2	0.60862186
65	LIMK1	0.58469487
66	CDK3	0.58006636
67	GRK7	0.57751050
68	MAPK13	0.56307883
69	DAPK1	0.56048267
70	AURKA	0.55764644
71	ADRBK1	0.54692301
72	PIM2	0.53423908
73	BTK	0.52778736
74	PTK2B	0.52162569
75	MKNK1	0.51872322
76	NME1	0.50474476
77	OXSR1	0.48298244
78	CDC7	0.48101742
79	NLK	0.47457920
80	CSNK2A2	0.47170167
81	EIF2AK2	0.47093659
82	PLK1	0.47048314
83	CCNB1	0.46536945
84	LYN	0.45945710
85	STK39	0.45311938
86	CSNK2A1	0.43888721
87	PLK3	0.43642826
88	OBSCN	0.43568104
89	MAPKAPK5	0.43072236
90	FES	0.42952060
91	MKNK2	0.42083019
92	CSNK1A1L	0.41880206
93	PRKACA	0.39506961
94	PRKCD	0.39337647
95	CSNK1A1	0.39319677
96	ATR	0.39258692
97	PRKCA	0.36364692
98	PRKD2	0.35366931
99	CHEK2	0.35210877
100	DYRK1A	0.34900229

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.18694513
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.50769188
3	Proteasome_Homo sapiens_hsa03050	3.39957209
4	Parkinsons disease_Homo sapiens_hsa05012	3.05052532
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.73521297
6	RNA polymerase_Homo sapiens_hsa03020	2.71163502
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.07752461
8	Huntingtons disease_Homo sapiens_hsa05016	1.97718849
9	Alzheimers disease_Homo sapiens_hsa05010	1.97552119
10	Allograft rejection_Homo sapiens_hsa05330	1.94525308
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.84631615
12	Asthma_Homo sapiens_hsa05310	1.81223584
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.78334912
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73126636
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67822323
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63316163
17	Homologous recombination_Homo sapiens_hsa03440	1.62431201
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.61026694
19	Protein export_Homo sapiens_hsa03060	1.59867004
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.59429548
21	Phototransduction_Homo sapiens_hsa04744	1.56472391
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53260291
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53137888
24	One carbon pool by folate_Homo sapiens_hsa00670	1.49982732
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.49615876
26	Sulfur relay system_Homo sapiens_hsa04122	1.47042181
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39066352
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38711982
29	RNA degradation_Homo sapiens_hsa03018	1.36683080
30	Peroxisome_Homo sapiens_hsa04146	1.36140600
31	Sulfur metabolism_Homo sapiens_hsa00920	1.29088844
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.28725020
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27992404
34	DNA replication_Homo sapiens_hsa03030	1.20023432
35	Base excision repair_Homo sapiens_hsa03410	1.16566147
36	Basal transcription factors_Homo sapiens_hsa03022	1.14466661
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14370407
38	Purine metabolism_Homo sapiens_hsa00230	1.13046494
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.10991142
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10100330
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08086039
42	Propanoate metabolism_Homo sapiens_hsa00640	1.05493504
43	Mismatch repair_Homo sapiens_hsa03430	1.04581716
44	Olfactory transduction_Homo sapiens_hsa04740	1.04214297
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03142334
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.96633325
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.93548655
48	Caffeine metabolism_Homo sapiens_hsa00232	0.93077741
49	Retinol metabolism_Homo sapiens_hsa00830	0.89196891
50	RNA transport_Homo sapiens_hsa03013	0.88860688
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87398890
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87372177
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.85827918
54	Spliceosome_Homo sapiens_hsa03040	0.85333532
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84151757
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82901717
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82018086
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81069809
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79509733
60	Regulation of autophagy_Homo sapiens_hsa04140	0.75869794
61	Butanoate metabolism_Homo sapiens_hsa00650	0.73294164
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72841588
63	Metabolic pathways_Homo sapiens_hsa01100	0.72461906
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.71584731
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66284201
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66224288
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65598569
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65109139
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62820696
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62443991
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62349456
72	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.61294895
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60976245
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60590180
75	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60103637
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55016976
77	Fatty acid degradation_Homo sapiens_hsa00071	0.53604732
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52000631
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51750141
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51705656
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51186601
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49524445
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.49151760
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.47454508
85	Nicotine addiction_Homo sapiens_hsa05033	0.45649207
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43291785
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42195824
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.42021395
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41403507
90	Taste transduction_Homo sapiens_hsa04742	0.40691473
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38692179
92	Glutathione metabolism_Homo sapiens_hsa00480	0.34912161
93	Herpes simplex infection_Homo sapiens_hsa05168	0.33569732
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30461447
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27986807
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26471616
97	Leishmaniasis_Homo sapiens_hsa05140	0.25772487
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.25514059
99	Viral myocarditis_Homo sapiens_hsa05416	0.24694932
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.23866386

RPSAP19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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