RPSAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.50477754
2maturation of SSU-rRNA (GO:0030490)7.36778187
3viral transcription (GO:0019083)5.97016327
4translational termination (GO:0006415)5.75163674
5ribosomal small subunit biogenesis (GO:0042274)5.35038853
6chaperone-mediated protein transport (GO:0072321)5.13100964
7translational elongation (GO:0006414)4.90191205
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.81102052
9cotranslational protein targeting to membrane (GO:0006613)4.79490755
10water-soluble vitamin biosynthetic process (GO:0042364)4.78292944
11protein targeting to ER (GO:0045047)4.74784469
12DNA deamination (GO:0045006)4.54665182
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.53430863
14protein localization to endoplasmic reticulum (GO:0070972)4.45899627
15viral life cycle (GO:0019058)4.30827250
16cellular protein complex disassembly (GO:0043624)4.28354465
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.19356089
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.16931815
19behavioral response to nicotine (GO:0035095)4.09872491
20ATP synthesis coupled proton transport (GO:0015986)3.96954917
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96954917
22ribosomal large subunit biogenesis (GO:0042273)3.86506046
23piRNA metabolic process (GO:0034587)3.86054863
24translational initiation (GO:0006413)3.85213048
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.73627633
26protein complex disassembly (GO:0043241)3.68653144
27regulation of cilium movement (GO:0003352)3.66643053
28regulation of immunoglobulin secretion (GO:0051023)3.63927393
29nonmotile primary cilium assembly (GO:0035058)3.62705544
30macromolecular complex disassembly (GO:0032984)3.55043809
31protein complex biogenesis (GO:0070271)3.39178198
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35240536
33translation (GO:0006412)3.32998568
34somite development (GO:0061053)3.28940449
35cellular component biogenesis (GO:0044085)3.25315300
36ribonucleoprotein complex biogenesis (GO:0022613)3.25219970
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24501676
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21592959
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.21592959
40NADH dehydrogenase complex assembly (GO:0010257)3.21592959
41detection of light stimulus involved in sensory perception (GO:0050962)3.14600046
42detection of light stimulus involved in visual perception (GO:0050908)3.14600046
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.13942827
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13805245
45regulation of isotype switching to IgG isotypes (GO:0048302)3.12236208
46cell proliferation in forebrain (GO:0021846)3.10348280
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09470942
48protein targeting to membrane (GO:0006612)3.08129954
49pseudouridine synthesis (GO:0001522)3.07298817
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.04746250
51mRNA catabolic process (GO:0006402)3.04709261
52negative regulation of telomere maintenance (GO:0032205)3.00105898
53mitochondrial respiratory chain complex assembly (GO:0033108)2.99723603
54protein-cofactor linkage (GO:0018065)2.99258239
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98072869
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98072869
57tRNA processing (GO:0008033)2.89267634
58ubiquinone biosynthetic process (GO:0006744)2.88793380
59nephron epithelium morphogenesis (GO:0072088)2.88172255
60nephron tubule morphogenesis (GO:0072078)2.88172255
61synapsis (GO:0007129)2.86907809
62GTP biosynthetic process (GO:0006183)2.85389546
63RNA catabolic process (GO:0006401)2.84219749
64regulation of microtubule-based movement (GO:0060632)2.83890616
65tRNA modification (GO:0006400)2.83032101
66estrogen biosynthetic process (GO:0006703)2.78534141
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.76617586
68termination of RNA polymerase III transcription (GO:0006386)2.76617586
69DNA replication checkpoint (GO:0000076)2.75557503
70regulation of mitochondrial translation (GO:0070129)2.72782618
71rRNA metabolic process (GO:0016072)2.72440144
72rRNA processing (GO:0006364)2.71245228
73hypothalamus development (GO:0021854)2.69013633
74photoreceptor cell maintenance (GO:0045494)2.68687201
75positive regulation of respiratory burst (GO:0060267)2.68354737
76epithelial cilium movement (GO:0003351)2.65456467
77axonemal dynein complex assembly (GO:0070286)2.63615437
78ubiquinone metabolic process (GO:0006743)2.62218122
79negative regulation of response to food (GO:0032096)2.61502117
80negative regulation of appetite (GO:0032099)2.61502117
81retinal rod cell development (GO:0046548)2.59907044
82cellular ketone body metabolic process (GO:0046950)2.58972724
83glyoxylate metabolic process (GO:0046487)2.57798467
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57320606
85isotype switching (GO:0045190)2.57320606
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57320606
87resolution of meiotic recombination intermediates (GO:0000712)2.56848819
88protein polyglutamylation (GO:0018095)2.56809261
89head development (GO:0060322)2.55416293
90S-adenosylmethionine metabolic process (GO:0046500)2.54045089
91L-fucose catabolic process (GO:0042355)2.52561884
92fucose catabolic process (GO:0019317)2.52561884
93L-fucose metabolic process (GO:0042354)2.52561884
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50492381
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50390342
96DNA methylation involved in gamete generation (GO:0043046)2.50046462
97cardiovascular system development (GO:0072358)2.48201821
98positive regulation of mitochondrial fission (GO:0090141)2.45166524
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.45016483
100electron transport chain (GO:0022900)2.44783595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.07546039
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68161228
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59248610
4EZH2_22144423_ChIP-Seq_EOC_Human3.24891257
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19755041
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04397189
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.95623732
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75194079
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.61640809
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55443000
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.54253798
12IRF1_19129219_ChIP-ChIP_H3396_Human2.53035258
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52674263
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22019453
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.15700875
16VDR_22108803_ChIP-Seq_LS180_Human2.10989113
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07317848
18VDR_23849224_ChIP-Seq_CD4+_Human2.05748523
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03557892
20MYC_18940864_ChIP-ChIP_HL60_Human2.03305583
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.92734741
22TP53_22573176_ChIP-Seq_HFKS_Human1.85130910
23FOXP3_21729870_ChIP-Seq_TREG_Human1.84696554
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83063069
25TTF2_22483619_ChIP-Seq_HELA_Human1.73212204
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68922052
27ELK1_19687146_ChIP-ChIP_HELA_Human1.66848072
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.57963393
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56441687
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54387928
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52670502
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51700565
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51246583
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50451847
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.49610039
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44683870
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43089671
38XRN2_22483619_ChIP-Seq_HELA_Human1.38107055
39EWS_26573619_Chip-Seq_HEK293_Human1.37704592
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37164407
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.31046953
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31046953
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28917828
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27065618
45GABP_19822575_ChIP-Seq_HepG2_Human1.26412178
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26201686
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25558728
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24581059
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20267915
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20177534
51AR_20517297_ChIP-Seq_VCAP_Human1.19754485
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.19139199
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17419124
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17298461
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17022615
56ERA_21632823_ChIP-Seq_H3396_Human1.16134305
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15897328
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15272727
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12335230
60NANOG_20526341_ChIP-Seq_ESCs_Human1.11827507
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10337141
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09973733
63TAF2_19829295_ChIP-Seq_ESCs_Human1.08195211
64NCOR_22424771_ChIP-Seq_293T_Human1.03247371
65HOXB7_26014856_ChIP-Seq_BT474_Human1.02895424
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01670225
67RNF2_27304074_Chip-Seq_NSC_Mouse1.00584106
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00128263
69REST_21632747_ChIP-Seq_MESCs_Mouse0.98880173
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98501770
71POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97415850
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96856332
73MYC_19829295_ChIP-Seq_ESCs_Human0.96210680
74P300_19829295_ChIP-Seq_ESCs_Human0.95886795
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95556455
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95360863
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.94885789
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93789599
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93522329
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91021473
81THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90732997
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90728175
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88407839
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88299135
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88175539
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88084110
87WDR5_24793694_ChIP-Seq_LNCAP_Human0.87889585
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.87598876
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.87427143
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86373805
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.85980752
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.85764589
93SOX2_19829295_ChIP-Seq_ESCs_Human0.85762817
94NANOG_19829295_ChIP-Seq_ESCs_Human0.85762817
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.85598406
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85285281
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.84752090
98E2F1_20622854_ChIP-Seq_HELA_Human0.81990534
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81492418
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81396342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.67804484
2MP0006292_abnormal_olfactory_placode4.66880601
3MP0008877_abnormal_DNA_methylation2.98008107
4MP0006072_abnormal_retinal_apoptosis2.72803588
5MP0003011_delayed_dark_adaptation2.50771231
6MP0001348_abnormal_lacrimal_gland2.50216666
7MP0008872_abnormal_physiological_respon2.20940489
8MP0001293_anophthalmia2.08353505
9MP0008875_abnormal_xenobiotic_pharmacok2.07681818
10MP0001873_stomach_inflammation1.98212880
11MP0004142_abnormal_muscle_tone1.97463613
12MP0001968_abnormal_touch/_nociception1.96591441
13MP0002653_abnormal_ependyma_morphology1.96004678
14MP0003878_abnormal_ear_physiology1.88233797
15MP0005377_hearing/vestibular/ear_phenot1.88233797
16MP0004885_abnormal_endolymph1.88116524
17MP0005551_abnormal_eye_electrophysiolog1.82701400
18MP0001986_abnormal_taste_sensitivity1.72218339
19MP0004147_increased_porphyrin_level1.71971980
20MP0008789_abnormal_olfactory_epithelium1.70114201
21MP0002102_abnormal_ear_morphology1.66606640
22MP0001529_abnormal_vocalization1.66128034
23MP0001485_abnormal_pinna_reflex1.65480706
24MP0002736_abnormal_nociception_after1.64950577
25MP0005253_abnormal_eye_physiology1.63303247
26MP0010030_abnormal_orbit_morphology1.61839877
27MP0006276_abnormal_autonomic_nervous1.61737483
28MP0003646_muscle_fatigue1.57055786
29MP0003136_yellow_coat_color1.56340564
30MP0005167_abnormal_blood-brain_barrier1.46291371
31MP0005646_abnormal_pituitary_gland1.44037336
32MP0005389_reproductive_system_phenotype1.43927960
33MP0004145_abnormal_muscle_electrophysio1.43640973
34MP0002938_white_spotting1.42252135
35MP0005174_abnormal_tail_pigmentation1.40697546
36MP0004043_abnormal_pH_regulation1.39471857
37MP0002160_abnormal_reproductive_system1.37168484
38MP0002277_abnormal_respiratory_mucosa1.34834416
39MP0004742_abnormal_vestibular_system1.33405116
40MP0003122_maternal_imprinting1.32704028
41MP0002272_abnormal_nervous_system1.31795004
42MP0002210_abnormal_sex_determination1.25867746
43MP0001919_abnormal_reproductive_system1.25073086
44MP0002095_abnormal_skin_pigmentation1.19525989
45MP0001440_abnormal_grooming_behavior1.15165079
46MP0008775_abnormal_heart_ventricle1.15137252
47MP0000569_abnormal_digit_pigmentation1.12446522
48MP0005084_abnormal_gallbladder_morpholo1.12381950
49MP0002163_abnormal_gland_morphology1.11067800
50MP0006035_abnormal_mitochondrial_morpho1.09918910
51MP0003315_abnormal_perineum_morphology1.08368249
52MP0002557_abnormal_social/conspecific_i1.08313820
53MP0005394_taste/olfaction_phenotype1.08116771
54MP0005499_abnormal_olfactory_system1.08116771
55MP0005195_abnormal_posterior_eye1.07897787
56MP0002735_abnormal_chemical_nociception1.07676341
57MP0002928_abnormal_bile_duct1.06293830
58MP0003186_abnormal_redox_activity1.06149957
59MP0005085_abnormal_gallbladder_physiolo1.06017561
60MP0000778_abnormal_nervous_system1.04425800
61MP0001905_abnormal_dopamine_level1.04199182
62MP0009745_abnormal_behavioral_response1.03428239
63MP0005379_endocrine/exocrine_gland_phen1.02774421
64MP0002138_abnormal_hepatobiliary_system1.00893248
65MP0008058_abnormal_DNA_repair1.00668530
66MP0001929_abnormal_gametogenesis1.00087761
67MP0005645_abnormal_hypothalamus_physiol0.99180820
68MP0001145_abnormal_male_reproductive0.96002907
69MP0005391_vision/eye_phenotype0.95843514
70MP0002733_abnormal_thermal_nociception0.94305427
71MP0000653_abnormal_sex_gland0.93444806
72MP0000427_abnormal_hair_cycle0.93004296
73MP0001970_abnormal_pain_threshold0.90994248
74MP0000049_abnormal_middle_ear0.90550188
75MP0005671_abnormal_response_to0.89708320
76MP0002752_abnormal_somatic_nervous0.88122598
77MP0000026_abnormal_inner_ear0.88109254
78MP0003252_abnormal_bile_duct0.87737484
79MP0001486_abnormal_startle_reflex0.87617096
80MP0003938_abnormal_ear_development0.87020939
81MP0003787_abnormal_imprinting0.86047166
82MP0003718_maternal_effect0.85985305
83MP0001963_abnormal_hearing_physiology0.85267763
84MP0003195_calcinosis0.84935052
85MP0003119_abnormal_digestive_system0.83691354
86MP0003693_abnormal_embryo_hatching0.83199897
87MP0002282_abnormal_trachea_morphology0.80464681
88MP0000631_abnormal_neuroendocrine_gland0.79661827
89MP0001502_abnormal_circadian_rhythm0.78864497
90MP0003698_abnormal_male_reproductive0.78677515
91MP0002572_abnormal_emotion/affect_behav0.77896736
92MP0003937_abnormal_limbs/digits/tail_de0.76617925
93MP0006036_abnormal_mitochondrial_physio0.75905614
94MP0002837_dystrophic_cardiac_calcinosis0.75393092
95MP0002734_abnormal_mechanical_nocicepti0.75095269
96MP0005410_abnormal_fertilization0.74630656
97MP0003936_abnormal_reproductive_system0.73997015
98MP0000372_irregular_coat_pigmentation0.73914057
99MP0003880_abnormal_central_pattern0.73666615
100MP0005408_hypopigmentation0.72616433

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.49803855
2Increased hepatocellular lipid droplets (HP:0006565)3.97881762
3Lipid accumulation in hepatocytes (HP:0006561)3.78149635
4Pancreatic fibrosis (HP:0100732)3.74549347
5Pancreatic cysts (HP:0001737)3.65239410
6Abnormality of cells of the erythroid lineage (HP:0012130)3.48598540
7Colon cancer (HP:0003003)3.27840957
8Decreased electroretinogram (ERG) amplitude (HP:0000654)3.20629101
9Molar tooth sign on MRI (HP:0002419)3.15272717
10Abnormality of midbrain morphology (HP:0002418)3.15272717
11Pendular nystagmus (HP:0012043)3.13772445
12Absent thumb (HP:0009777)3.01985056
13Rib fusion (HP:0000902)2.94562555
14Aplasia/Hypoplasia of the spleen (HP:0010451)2.93041445
15Decreased central vision (HP:0007663)2.87918723
16Abnormal number of erythroid precursors (HP:0012131)2.86251847
17Macrocytic anemia (HP:0001972)2.85778093
18Septo-optic dysplasia (HP:0100842)2.83056259
19Increased intramyocellular lipid droplets (HP:0012240)2.80351469
20Asplenia (HP:0001746)2.78352137
21Abolished electroretinogram (ERG) (HP:0000550)2.72419223
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70974973
23True hermaphroditism (HP:0010459)2.70231625
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69662162
25Supernumerary spleens (HP:0009799)2.67971613
26Increased CSF lactate (HP:0002490)2.66524572
27Abnormal biliary tract physiology (HP:0012439)2.65596258
28Bile duct proliferation (HP:0001408)2.65596258
29Mitochondrial inheritance (HP:0001427)2.64402064
30Renal Fanconi syndrome (HP:0001994)2.64234007
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63229338
32Pallor (HP:0000980)2.60892136
33Increased serum lactate (HP:0002151)2.59629946
34Acute necrotizing encephalopathy (HP:0006965)2.59115978
35Large for gestational age (HP:0001520)2.56966778
36Chorioretinal atrophy (HP:0000533)2.55699937
373-Methylglutaconic aciduria (HP:0003535)2.55276115
38Abnormal rod and cone electroretinograms (HP:0008323)2.44638485
39Anophthalmia (HP:0000528)2.42888234
40Medial flaring of the eyebrow (HP:0010747)2.42035314
41Type II lissencephaly (HP:0007260)2.41471076
42Abnormal mitochondria in muscle tissue (HP:0008316)2.39752867
43Sclerocornea (HP:0000647)2.38451722
44Cystic liver disease (HP:0006706)2.37999718
45Congenital stationary night blindness (HP:0007642)2.34865586
46Increased muscle lipid content (HP:0009058)2.34149760
47Bilateral microphthalmos (HP:0007633)2.32364175
48Abnormality of the labia minora (HP:0012880)2.32258231
49Abnormality of DNA repair (HP:0003254)2.31752751
50Nephronophthisis (HP:0000090)2.24847872
51Abnormality of the renal collecting system (HP:0004742)2.22259085
52Acute encephalopathy (HP:0006846)2.20268420
53Abnormality of the renal medulla (HP:0100957)2.19742616
54Duplicated collecting system (HP:0000081)2.16482073
55Abnormality of alanine metabolism (HP:0010916)2.14475001
56Hyperalaninemia (HP:0003348)2.14475001
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14475001
58Ectopic kidney (HP:0000086)2.13961703
59Abnormality of cochlea (HP:0000375)2.13663749
60Optic disc pallor (HP:0000543)2.12156476
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.08960341
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08199256
63Abnormality of the aortic arch (HP:0012303)2.06757375
64Exertional dyspnea (HP:0002875)2.05478049
65Respiratory difficulties (HP:0002880)2.04512928
66Cerebellar dysplasia (HP:0007033)2.03876081
67Hypoplasia of the ulna (HP:0003022)2.03769830
68Progressive macrocephaly (HP:0004481)2.01641893
69Optic nerve hypoplasia (HP:0000609)2.01407548
70Chromsome breakage (HP:0040012)2.00068888
71Abnormality of the diencephalon (HP:0010662)1.99751010
72Tubular atrophy (HP:0000092)1.98581033
73Lactic acidosis (HP:0003128)1.96909998
74Oligodactyly (HP:0012165)1.96397112
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95789871
76Attenuation of retinal blood vessels (HP:0007843)1.93442283
77Short tibia (HP:0005736)1.92766800
78Anencephaly (HP:0002323)1.92411070
79Abnormal drinking behavior (HP:0030082)1.91328263
80Polydipsia (HP:0001959)1.91328263
81IgG deficiency (HP:0004315)1.90406936
82Hypoplasia of the pons (HP:0012110)1.89834091
83Hyperglycinemia (HP:0002154)1.88333371
84Abnormality of the pons (HP:0007361)1.88085174
85Aplasia/Hypoplasia of the ulna (HP:0006495)1.87604686
86Methylmalonic aciduria (HP:0012120)1.87534265
87Ketosis (HP:0001946)1.86019642
88Absent/shortened dynein arms (HP:0200106)1.84709327
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.84709327
90Hypomagnesemia (HP:0002917)1.84005843
91Congenital primary aphakia (HP:0007707)1.82397976
92Abnormality of the renal cortex (HP:0011035)1.81724975
93Forearm undergrowth (HP:0009821)1.81443922
94Posterior subcapsular cataract (HP:0007787)1.80406180
95Gait imbalance (HP:0002141)1.78929400
96Absent septum pellucidum (HP:0001331)1.78235531
97Polyuria (HP:0000103)1.77600676
98Postaxial foot polydactyly (HP:0001830)1.77365959
99Abnormal lung lobation (HP:0002101)1.76935729
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76858284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.28862226
2TLK14.18891787
3ZAK3.53002378
4ADRBK22.97566103
5NUAK12.73109087
6TIE12.66169353
7PBK2.64310652
8FRK2.59241698
9BCKDK2.51055368
10VRK22.31998159
11WNK32.15097364
12GRK12.09915712
13TXK2.00780477
14PASK1.98315488
15VRK11.77540857
16PINK11.66509045
17TSSK61.65233642
18BUB11.58885279
19CDK81.53908400
20CDK191.53178051
21STK391.48365377
22PIK3CA1.43764256
23STK161.38402874
24DYRK21.31879026
25EPHB21.27931799
26TYRO31.24141659
27MAPK151.19430098
28PLK31.18369894
29EPHA41.14742250
30PRKD31.08406294
31BMPR1B1.06498848
32FES1.03953204
33OXSR11.03706767
34CDC71.02954931
35TAF10.94640100
36MAP2K20.88034072
37NEK20.87987170
38WEE10.87447768
39SIK20.85043850
40MKNK20.84043750
41IKBKB0.83570844
42LRRK20.82470774
43RPS6KA50.80469573
44IRAK10.78514801
45IRAK40.78390175
46CASK0.75863962
47PRKCG0.73369585
48RPS6KA60.71794430
49ADRBK10.70443236
50STK40.70331706
51NEK10.70219287
52ATR0.70208401
53MAP2K70.67479784
54ALK0.66423396
55PRKCQ0.65823391
56MAP4K10.65499572
57MAP2K60.64891420
58PLK10.64425959
59TNIK0.64044767
60MAPKAPK50.63870477
61STK240.62505018
62PLK20.60631793
63MAP3K110.60313081
64NTRK20.59764915
65AURKB0.59552219
66ITK0.59109353
67MST40.56056537
68INSRR0.53308701
69PIK3CG0.52996133
70PLK40.52594239
71SRPK10.52016410
72CHEK20.50907992
73MAPKAPK30.50538425
74CAMK10.49914879
75PNCK0.49259554
76BRD40.48824640
77RPS6KL10.48607602
78RPS6KC10.48607602
79PIM10.48467105
80AURKA0.48232297
81PAK60.47835476
82MAP3K40.47524527
83CAMKK10.46924268
84STK110.42964658
85CSNK2A20.41694414
86CSNK1E0.40990758
87STK38L0.40244997
88PRKCE0.40076625
89PRKACA0.39715524
90RPS6KA20.39708753
91ATM0.39428399
92TEC0.38508975
93ERBB20.37991996
94GRK50.37880217
95CSNK2A10.37425017
96PHKG10.36660021
97PHKG20.36660021
98CSNK1G20.36565649
99MINK10.35160116
100TGFBR10.35070399

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.22919302
2Oxidative phosphorylation_Homo sapiens_hsa001902.73412943
3RNA polymerase_Homo sapiens_hsa030202.72451750
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49325809
5Parkinsons disease_Homo sapiens_hsa050122.33412097
6One carbon pool by folate_Homo sapiens_hsa006702.28992214
7Homologous recombination_Homo sapiens_hsa034402.01678345
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98215121
9Phototransduction_Homo sapiens_hsa047441.93339608
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93042753
11Proteasome_Homo sapiens_hsa030501.86666852
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81111545
13Sulfur relay system_Homo sapiens_hsa041221.78267868
14Nitrogen metabolism_Homo sapiens_hsa009101.77353847
15Protein export_Homo sapiens_hsa030601.76751977
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.72238285
17Linoleic acid metabolism_Homo sapiens_hsa005911.71252230
18Asthma_Homo sapiens_hsa053101.67765316
19Mismatch repair_Homo sapiens_hsa034301.67325820
20Huntingtons disease_Homo sapiens_hsa050161.61980207
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61234264
22Basal transcription factors_Homo sapiens_hsa030221.61201957
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59702072
24Cardiac muscle contraction_Homo sapiens_hsa042601.58285448
25RNA degradation_Homo sapiens_hsa030181.57689766
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.52151445
27DNA replication_Homo sapiens_hsa030301.52091438
28Peroxisome_Homo sapiens_hsa041461.42931830
29Fanconi anemia pathway_Homo sapiens_hsa034601.41950635
30Nucleotide excision repair_Homo sapiens_hsa034201.40915460
31Primary immunodeficiency_Homo sapiens_hsa053401.39420015
32Propanoate metabolism_Homo sapiens_hsa006401.35055081
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32669511
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31321316
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29641413
36Fatty acid biosynthesis_Homo sapiens_hsa000611.26456138
37Butanoate metabolism_Homo sapiens_hsa006501.25429858
38Allograft rejection_Homo sapiens_hsa053301.24003237
39Alzheimers disease_Homo sapiens_hsa050101.23618926
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21658997
41Autoimmune thyroid disease_Homo sapiens_hsa053201.21265677
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18910680
43Pyrimidine metabolism_Homo sapiens_hsa002401.18734230
44RNA transport_Homo sapiens_hsa030131.18185327
45Steroid biosynthesis_Homo sapiens_hsa001001.12781183
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11973385
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09653972
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09565234
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08611929
50Tryptophan metabolism_Homo sapiens_hsa003801.06361083
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06279708
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01413504
53Arachidonic acid metabolism_Homo sapiens_hsa005900.99789179
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94631637
55Purine metabolism_Homo sapiens_hsa002300.91214077
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.89288482
57Systemic lupus erythematosus_Homo sapiens_hsa053220.86889323
58Ether lipid metabolism_Homo sapiens_hsa005650.83500567
59Olfactory transduction_Homo sapiens_hsa047400.80549877
60Spliceosome_Homo sapiens_hsa030400.80097570
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.77819437
62Metabolic pathways_Homo sapiens_hsa011000.77126363
63Fatty acid metabolism_Homo sapiens_hsa012120.76566968
64Caffeine metabolism_Homo sapiens_hsa002320.75146554
65Base excision repair_Homo sapiens_hsa034100.72978732
66Fat digestion and absorption_Homo sapiens_hsa049750.71064846
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69489901
68Chemical carcinogenesis_Homo sapiens_hsa052040.66329956
69Retinol metabolism_Homo sapiens_hsa008300.66010869
70Basal cell carcinoma_Homo sapiens_hsa052170.62678064
71Sulfur metabolism_Homo sapiens_hsa009200.62654858
72Nicotine addiction_Homo sapiens_hsa050330.62403849
73Pyruvate metabolism_Homo sapiens_hsa006200.60588738
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60376794
75Ovarian steroidogenesis_Homo sapiens_hsa049130.59907735
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55881216
77Folate biosynthesis_Homo sapiens_hsa007900.55570823
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55076474
79Hedgehog signaling pathway_Homo sapiens_hsa043400.54690217
80Arginine and proline metabolism_Homo sapiens_hsa003300.54386619
81Mineral absorption_Homo sapiens_hsa049780.52056097
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51852425
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48074147
84Vitamin digestion and absorption_Homo sapiens_hsa049770.47778365
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46162626
86Starch and sucrose metabolism_Homo sapiens_hsa005000.45896322
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45893852
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45123304
89beta-Alanine metabolism_Homo sapiens_hsa004100.44100007
90Fatty acid degradation_Homo sapiens_hsa000710.43761202
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38466915
92Glycerolipid metabolism_Homo sapiens_hsa005610.35024456
93Morphine addiction_Homo sapiens_hsa050320.34458034
94Graft-versus-host disease_Homo sapiens_hsa053320.34335785
95Insulin secretion_Homo sapiens_hsa049110.34323211
96Fatty acid elongation_Homo sapiens_hsa000620.34101378
97Taste transduction_Homo sapiens_hsa047420.32448443
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32275375
99Glutathione metabolism_Homo sapiens_hsa004800.31388654
100Type I diabetes mellitus_Homo sapiens_hsa049400.26922141

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