RPSAP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)6.93749315
2behavioral response to nicotine (GO:0035095)6.30709085
3viral transcription (GO:0019083)6.04992514
4chaperone-mediated protein transport (GO:0072321)5.94030443
5translational termination (GO:0006415)5.76271129
6ribosomal small subunit assembly (GO:0000028)5.33792060
7ribosomal small subunit biogenesis (GO:0042274)5.12302251
8response to pheromone (GO:0019236)4.93002853
9translational elongation (GO:0006414)4.89463864
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.81637897
11pattern specification involved in kidney development (GO:0061004)4.76776953
12protein targeting to ER (GO:0045047)4.73035258
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.71821737
14cotranslational protein targeting to membrane (GO:0006613)4.68558034
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66099791
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.52280033
17pyrimidine nucleobase catabolic process (GO:0006208)4.44572222
18viral life cycle (GO:0019058)4.43657974
19protein localization to endoplasmic reticulum (GO:0070972)4.41676498
20cellular protein complex disassembly (GO:0043624)4.39880681
21head development (GO:0060322)4.32485442
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26103975
23ATP synthesis coupled proton transport (GO:0015986)4.26103975
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20285364
25synaptic transmission, cholinergic (GO:0007271)4.04238611
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.95017745
27translational initiation (GO:0006413)3.87800088
28protein complex biogenesis (GO:0070271)3.86137705
29water-soluble vitamin biosynthetic process (GO:0042364)3.84071668
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79848762
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.79848762
32NADH dehydrogenase complex assembly (GO:0010257)3.79848762
33protein complex disassembly (GO:0043241)3.77568222
34GTP biosynthetic process (GO:0006183)3.76009591
35kinetochore assembly (GO:0051382)3.71206081
36mitochondrial respiratory chain complex assembly (GO:0033108)3.63899600
37macromolecular complex disassembly (GO:0032984)3.57604404
38L-serine metabolic process (GO:0006563)3.57415904
39nucleobase catabolic process (GO:0046113)3.54427139
40DNA deamination (GO:0045006)3.44373705
41kinetochore organization (GO:0051383)3.39701805
42startle response (GO:0001964)3.38534312
43UTP biosynthetic process (GO:0006228)3.29520399
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28345383
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28345383
46nonmotile primary cilium assembly (GO:0035058)3.27119251
47protein targeting to membrane (GO:0006612)3.24094959
48negative regulation of telomere maintenance (GO:0032205)3.23288859
49motile cilium assembly (GO:0044458)3.13497954
50ovulation cycle (GO:0042698)3.11926504
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.11445761
52translation (GO:0006412)3.10207054
53kidney morphogenesis (GO:0060993)3.09454875
54ubiquinone biosynthetic process (GO:0006744)3.05465116
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04378461
56UTP metabolic process (GO:0046051)3.02749888
57hypothalamus development (GO:0021854)3.00506625
58CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.99998065
59cellular component biogenesis (GO:0044085)2.98393360
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98259872
61cell proliferation in forebrain (GO:0021846)2.94127647
62mRNA catabolic process (GO:0006402)2.92803849
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89191810
64ribosomal large subunit biogenesis (GO:0042273)2.85102156
65regulation of isotype switching to IgG isotypes (GO:0048302)2.84915594
66segment specification (GO:0007379)2.81750087
67negative regulation of organelle assembly (GO:1902116)2.81519128
68protein neddylation (GO:0045116)2.80645133
69ribonucleoprotein complex biogenesis (GO:0022613)2.80115016
70regulation of telomere maintenance (GO:0032204)2.79764241
71postsynaptic membrane organization (GO:0001941)2.79549796
72protein localization to cilium (GO:0061512)2.79114614
73epithelial cilium movement (GO:0003351)2.78751866
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77739197
75establishment of mitochondrion localization (GO:0051654)2.76606357
76olfactory bulb development (GO:0021772)2.74969253
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73971230
78positive regulation of neurological system process (GO:0031646)2.72174241
79ubiquinone metabolic process (GO:0006743)2.71446053
80RNA catabolic process (GO:0006401)2.71055833
81intraciliary transport (GO:0042073)2.69276872
82transmission of nerve impulse (GO:0019226)2.68485026
83regulation of female gonad development (GO:2000194)2.64614795
84positive regulation of fatty acid oxidation (GO:0046321)2.63866467
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.63748804
86tyrosine phosphorylation of STAT protein (GO:0007260)2.61727156
87Sertoli cell development (GO:0060009)2.60372092
88axonemal dynein complex assembly (GO:0070286)2.59116811
89regulation of mitochondrial translation (GO:0070129)2.56275724
90CTP biosynthetic process (GO:0006241)2.56028586
91CTP metabolic process (GO:0046036)2.56028586
92isoprenoid biosynthetic process (GO:0008299)2.55528012
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55376159
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55139103
95purine nucleoside triphosphate biosynthetic process (GO:0009145)2.54906971
96regulation of transmission of nerve impulse (GO:0051969)2.52202067
97estrogen biosynthetic process (GO:0006703)2.52004852
98regulation of action potential (GO:0098900)2.51300769
99replication fork processing (GO:0031297)2.50227628
100regulation of autophagic vacuole assembly (GO:2000785)2.49306198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81212389
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.64826559
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88098141
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.80177980
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44788945
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19659327
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01196669
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92971315
9CBX2_27304074_Chip-Seq_ESCs_Mouse1.91349412
10VDR_22108803_ChIP-Seq_LS180_Human1.89686735
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88159085
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.83277414
13EZH2_27294783_Chip-Seq_ESCs_Mouse1.82959109
14REST_21632747_ChIP-Seq_MESCs_Mouse1.80453681
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.79409141
16ZNF274_21170338_ChIP-Seq_K562_Hela1.78073495
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76327136
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.75577075
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72775586
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70747849
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68354202
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62550020
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60028513
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.54052884
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53077904
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51700861
27SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49611244
28TTF2_22483619_ChIP-Seq_HELA_Human1.47629260
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47603380
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.46792235
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43693903
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41121318
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39553525
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39517793
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39290564
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.38818295
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37681085
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37595632
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35102506
40TAF2_19829295_ChIP-Seq_ESCs_Human1.32555781
41MYC_18940864_ChIP-ChIP_HL60_Human1.32195594
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.31776896
43ERA_21632823_ChIP-Seq_H3396_Human1.31598824
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31302774
45NANOG_20526341_ChIP-Seq_ESCs_Human1.28996108
46TP53_22573176_ChIP-Seq_HFKS_Human1.28860845
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28513702
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.27805403
49RNF2_27304074_Chip-Seq_NSC_Mouse1.27435923
50GABP_19822575_ChIP-Seq_HepG2_Human1.25722564
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25671009
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25446611
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25312120
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.25285775
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25162728
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25031644
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23094042
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.21203290
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20114460
60CTCF_27219007_Chip-Seq_Bcells_Human1.19142637
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17578370
62BCL6_27268052_Chip-Seq_Bcells_Human1.16449510
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15048615
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14212032
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12810802
66NCOR_22424771_ChIP-Seq_293T_Human1.12557937
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10313636
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09065461
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08955967
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08328433
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07517532
72TP53_22127205_ChIP-Seq_IMR90_Human1.06187981
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05569776
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05569776
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.04311669
76P53_21459846_ChIP-Seq_SAOS-2_Human1.02901086
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01464276
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.01179214
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01166854
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99921880
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99859139
82VDR_23849224_ChIP-Seq_CD4+_Human0.98555530
83NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98492276
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97393162
85FOXP3_21729870_ChIP-Seq_TREG_Human0.97045103
86P300_19829295_ChIP-Seq_ESCs_Human0.96381555
87E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96081769
88CTCF_20526341_ChIP-Seq_ESCs_Human0.95998506
89STAT1_20625510_ChIP-Seq_HELA_Human0.95669632
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.95115620
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.94651034
92SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93522828
93P68_20966046_ChIP-Seq_HELA_Human0.93459087
94E2F1_20622854_ChIP-Seq_HELA_Human0.93030683
95SA1_27219007_Chip-Seq_Bcells_Human0.93011672
96CBP_20019798_ChIP-Seq_JUKART_Human0.91734304
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91734304
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91262720
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90808362
100ER_23166858_ChIP-Seq_MCF-7_Human0.90279203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.83180569
2MP0003122_maternal_imprinting4.03620950
3MP0003646_muscle_fatigue3.11088928
4MP0005646_abnormal_pituitary_gland3.09227199
5MP0003787_abnormal_imprinting2.86775590
6MP0004885_abnormal_endolymph2.79539934
7MP0006292_abnormal_olfactory_placode2.75202423
8MP0008877_abnormal_DNA_methylation2.72455507
9MP0004142_abnormal_muscle_tone2.68373673
10MP0003121_genomic_imprinting2.67712267
11MP0005377_hearing/vestibular/ear_phenot2.66304235
12MP0003878_abnormal_ear_physiology2.66304235
13MP0001529_abnormal_vocalization2.59617619
14MP0006276_abnormal_autonomic_nervous2.38597025
15MP0003136_yellow_coat_color2.36156568
16MP0003879_abnormal_hair_cell2.33664543
17MP0001348_abnormal_lacrimal_gland2.07226460
18MP0002102_abnormal_ear_morphology2.02416213
19MP0001440_abnormal_grooming_behavior1.95236504
20MP0001873_stomach_inflammation1.94069918
21MP0001485_abnormal_pinna_reflex1.91165965
22MP0001188_hyperpigmentation1.85352312
23MP0000049_abnormal_middle_ear1.85341062
24MP0002138_abnormal_hepatobiliary_system1.84358300
25MP0003567_abnormal_fetal_cardiomyocyte1.79023535
26MP0004742_abnormal_vestibular_system1.77992098
27MP0000778_abnormal_nervous_system1.73960151
28MP0008875_abnormal_xenobiotic_pharmacok1.69954487
29MP0008789_abnormal_olfactory_epithelium1.63843832
30MP0002557_abnormal_social/conspecific_i1.60155857
31MP0000631_abnormal_neuroendocrine_gland1.58912330
32MP0003315_abnormal_perineum_morphology1.49834807
33MP0008872_abnormal_physiological_respon1.47906102
34MP0002653_abnormal_ependyma_morphology1.44516886
35MP0005499_abnormal_olfactory_system1.43226530
36MP0005394_taste/olfaction_phenotype1.43226530
37MP0005551_abnormal_eye_electrophysiolog1.38617506
38MP0001968_abnormal_touch/_nociception1.27776760
39MP0004145_abnormal_muscle_electrophysio1.26306827
40MP0005386_behavior/neurological_phenoty1.26299980
41MP0004924_abnormal_behavior1.26299980
42MP0001984_abnormal_olfaction1.25334921
43MP0004133_heterotaxia1.24478114
44MP0002272_abnormal_nervous_system1.22907189
45MP0009745_abnormal_behavioral_response1.19447880
46MP0005084_abnormal_gallbladder_morpholo1.18961762
47MP0002063_abnormal_learning/memory/cond1.18125494
48MP0002938_white_spotting1.17954439
49MP0000613_abnormal_salivary_gland1.15345367
50MP0005423_abnormal_somatic_nervous1.12019866
51MP0001970_abnormal_pain_threshold1.11640888
52MP0000566_synostosis1.11211767
53MP0002733_abnormal_thermal_nociception1.10171304
54MP0000026_abnormal_inner_ear1.08974454
55MP0002638_abnormal_pupillary_reflex1.08676670
56MP0001963_abnormal_hearing_physiology1.05260633
57MP0003195_calcinosis1.04944839
58MP0001293_anophthalmia1.04676944
59MP0003880_abnormal_central_pattern1.03535803
60MP0003123_paternal_imprinting1.01452510
61MP0005408_hypopigmentation1.00686703
62MP0003635_abnormal_synaptic_transmissio1.00340632
63MP0002572_abnormal_emotion/affect_behav0.99700907
64MP0002876_abnormal_thyroid_physiology0.99530407
65MP0005389_reproductive_system_phenotype0.97420735
66MP0004147_increased_porphyrin_level0.96190706
67MP0001663_abnormal_digestive_system0.94956804
68MP0001486_abnormal_startle_reflex0.93736549
69MP0005167_abnormal_blood-brain_barrier0.93700041
70MP0002735_abnormal_chemical_nociception0.92259125
71MP0002067_abnormal_sensory_capabilities0.92129729
72MP0002184_abnormal_innervation0.91481783
73MP0005195_abnormal_posterior_eye0.91314444
74MP0008775_abnormal_heart_ventricle0.90521878
75MP0001905_abnormal_dopamine_level0.89704787
76MP0002234_abnormal_pharynx_morphology0.89067540
77MP0002064_seizures0.87861664
78MP0002736_abnormal_nociception_after0.87295411
79MP0009046_muscle_twitch0.86626549
80MP0000955_abnormal_spinal_cord0.85504243
81MP0005187_abnormal_penis_morphology0.85438659
82MP0002752_abnormal_somatic_nervous0.83401894
83MP0005670_abnormal_white_adipose0.83365100
84MP0003119_abnormal_digestive_system0.83234388
85MP0001919_abnormal_reproductive_system0.81438314
86MP0004859_abnormal_synaptic_plasticity0.79838042
87MP0009053_abnormal_anal_canal0.79624374
88MP0004043_abnormal_pH_regulation0.78552107
89MP0002163_abnormal_gland_morphology0.77686447
90MP0003942_abnormal_urinary_system0.77504327
91MP0002160_abnormal_reproductive_system0.77244526
92MP0002837_dystrophic_cardiac_calcinosis0.76653119
93MP0005645_abnormal_hypothalamus_physiol0.76538759
94MP0003937_abnormal_limbs/digits/tail_de0.76288134
95MP0008058_abnormal_DNA_repair0.74696602
96MP0002210_abnormal_sex_determination0.72271299
97MP0002734_abnormal_mechanical_nocicepti0.72026623
98MP0003011_delayed_dark_adaptation0.71434244
99MP0006035_abnormal_mitochondrial_morpho0.67792924
100MP0002152_abnormal_brain_morphology0.64393940

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.02358555
2Septo-optic dysplasia (HP:0100842)4.24042409
3Acute necrotizing encephalopathy (HP:0006965)3.59131377
4Lipid accumulation in hepatocytes (HP:0006561)3.48370879
5Aplasia/Hypoplasia of the spleen (HP:0010451)3.37625884
6Increased hepatocellular lipid droplets (HP:0006565)3.37123957
7Abnormality of DNA repair (HP:0003254)3.31265275
8Papilledema (HP:0001085)3.26931076
9Pancreatic fibrosis (HP:0100732)3.24633752
10Optic nerve hypoplasia (HP:0000609)3.22214282
11Abnormal mitochondria in muscle tissue (HP:0008316)3.21364662
12Asplenia (HP:0001746)3.16360265
13Acute encephalopathy (HP:0006846)3.09893479
14Abnormality of the labia minora (HP:0012880)3.07493958
15Ectopic kidney (HP:0000086)2.95050607
16Mitochondrial inheritance (HP:0001427)2.94523352
17Pancreatic cysts (HP:0001737)2.90077142
18Type II lissencephaly (HP:0007260)2.89406834
19Progressive macrocephaly (HP:0004481)2.87560245
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84357997
21Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.82322192
22Renal Fanconi syndrome (HP:0001994)2.79187620
23Macrocytic anemia (HP:0001972)2.74137402
24Growth hormone deficiency (HP:0000824)2.72984949
25Increased CSF lactate (HP:0002490)2.70483515
26Maternal diabetes (HP:0009800)2.70384665
27Lissencephaly (HP:0001339)2.65663504
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.64289481
29Absent/shortened dynein arms (HP:0200106)2.64289481
30Pachygyria (HP:0001302)2.60565407
31Abnormality of midbrain morphology (HP:0002418)2.57682206
32Molar tooth sign on MRI (HP:0002419)2.57682206
33Absent thumb (HP:0009777)2.45099223
34Rib fusion (HP:0000902)2.44978612
35Nephronophthisis (HP:0000090)2.44112458
36Abnormality of cells of the erythroid lineage (HP:0012130)2.43536256
37Increased intramyocellular lipid droplets (HP:0012240)2.42628659
38Hypoplasia of the radius (HP:0002984)2.41193480
39Pendular nystagmus (HP:0012043)2.39557231
40Anophthalmia (HP:0000528)2.39332591
41Morphological abnormality of the inner ear (HP:0011390)2.37251489
42Horseshoe kidney (HP:0000085)2.36517469
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36073495
44True hermaphroditism (HP:0010459)2.34480054
45Absent septum pellucidum (HP:0001331)2.32796512
46Optic disc pallor (HP:0000543)2.26852408
47Cerebellar dysplasia (HP:0007033)2.23477246
48Increased muscle lipid content (HP:0009058)2.23040730
49Failure to thrive in infancy (HP:0001531)2.22363356
50Abnormality of cochlea (HP:0000375)2.22157320
51Pallor (HP:0000980)2.21629819
52Forearm undergrowth (HP:0009821)2.18276884
53Abnormality of the renal medulla (HP:0100957)2.18165287
54Abnormal respiratory epithelium morphology (HP:0012253)2.16603705
55Abnormal respiratory motile cilium morphology (HP:0005938)2.16603705
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15868928
57Increased serum lactate (HP:0002151)2.14393914
58Abnormal biliary tract physiology (HP:0012439)2.13541150
59Bile duct proliferation (HP:0001408)2.13541150
60Colon cancer (HP:0003003)2.10469072
61Hepatocellular necrosis (HP:0001404)2.10127608
62Medial flaring of the eyebrow (HP:0010747)2.07256715
63Oligodactyly (HP:0012165)2.05533697
64Hypoplastic pelvis (HP:0008839)2.04805350
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04408143
66Congenital stationary night blindness (HP:0007642)2.04238747
67Hyperventilation (HP:0002883)2.04042375
68Progressive cerebellar ataxia (HP:0002073)2.03712078
69Hepatic necrosis (HP:0002605)2.02322456
70Hypoplasia of the ulna (HP:0003022)2.01719275
71Partial agenesis of the corpus callosum (HP:0001338)2.01697863
72Exertional dyspnea (HP:0002875)2.00849231
73Abnormal rod and cone electroretinograms (HP:0008323)1.99094166
74Abnormal ciliary motility (HP:0012262)1.98701993
75Poor suck (HP:0002033)1.97448439
76Polyphagia (HP:0002591)1.97445468
77Anosmia (HP:0000458)1.96659133
78Abnormal number of incisors (HP:0011064)1.94196690
79Gait imbalance (HP:0002141)1.94188033
80Abnormality of the septum pellucidum (HP:0007375)1.93903737
81Oligodactyly (hands) (HP:0001180)1.93628679
82Abnormal drinking behavior (HP:0030082)1.93499791
83Polydipsia (HP:0001959)1.93499791
84Supernumerary spleens (HP:0009799)1.92635994
85Anencephaly (HP:0002323)1.86546236
86Decreased muscle mass (HP:0003199)1.85751229
87Hyperthyroidism (HP:0000836)1.85087377
88Abnormality of the renal cortex (HP:0011035)1.83364684
89Abnormality of renal resorption (HP:0011038)1.80463648
90Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80457527
91Tubular atrophy (HP:0000092)1.80101647
92Cystic liver disease (HP:0006706)1.79341632
93Stenosis of the external auditory canal (HP:0000402)1.78978162
94Myokymia (HP:0002411)1.78948109
95Cerebral edema (HP:0002181)1.77769122
96Agitation (HP:0000713)1.77747502
97Oligomenorrhea (HP:0000876)1.76714568
98Abolished electroretinogram (ERG) (HP:0000550)1.76683561
99Hypogonadotrophic hypogonadism (HP:0000044)1.76582867
100Respiratory difficulties (HP:0002880)1.75793054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.38259391
2STK164.69741413
3DYRK23.28913596
4EPHB22.55040975
5NME12.54110487
6WNK42.52915927
7GRK12.41959338
8TNIK2.25919101
9BMPR1B2.21371722
10NUAK12.04983161
11PAK62.00389909
12CASK1.99299701
13TAOK31.95541773
14VRK21.87701828
15CAMK1D1.84314242
16PIK3CA1.69551665
17BCKDK1.65310131
18ADRBK21.56259774
19PIM21.41192165
20TAF11.40406262
21CAMKK21.38848957
22TYRO31.27265585
23STK391.17882361
24MARK11.15280093
25TGFBR11.13916461
26DAPK31.12159354
27DYRK1B1.11877528
28CAMK1G1.10918668
29NTRK21.09048546
30PDK21.07398967
31MAPK131.03824091
32EIF2AK11.01503247
33MAP4K21.00841298
34DAPK20.98388195
35PBK0.98255360
36CAMK10.97435472
37PAK30.96970918
38CDK80.94972547
39PRKCG0.91691235
40TXK0.91075555
41CDK190.89457171
42TSSK60.89338503
43CDC70.86755629
44MINK10.84803379
45NEK10.84605985
46PRKD30.83081401
47PLK20.81273259
48OBSCN0.81268760
49PHKG20.80789526
50PHKG10.80789526
51WNK30.72236876
52PRKCQ0.71698231
53OXSR10.70575460
54CCNB10.68237128
55PASK0.67748511
56PINK10.66947872
57FRK0.62635025
58PRKCI0.62228786
59LIMK10.61950710
60STK110.61655546
61EIF2AK20.60927890
62PLK30.59620770
63TEC0.57374554
64PRKCH0.56936786
65ALK0.56432031
66VRK10.56367089
67INSRR0.54708701
68PTK60.53766656
69SGK2230.51925333
70SGK4940.51925333
71LRRK20.50807527
72CSNK1E0.50699420
73TLK10.50204620
74SIK20.50197962
75AURKB0.48665920
76PLK10.48663489
77ERBB20.48415126
78WEE10.48391242
79SGK10.47858164
80CAMK2A0.46775837
81CSNK2A20.46535282
82CAMKK10.45610295
83FES0.45494994
84MAP2K70.45397904
85AURKA0.43745497
86MKNK20.43535439
87ZAK0.42615314
88RPS6KA60.41032589
89PRKCZ0.40938727
90AKT30.40877978
91CAMK40.39591403
92CHEK10.38885115
93PRKACA0.38671950
94ROCK10.38295354
95WNK10.38106430
96PKN10.37930787
97DMPK0.36706804
98ATR0.36175660
99KIT0.35914731
100PIK3CG0.35803159

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.77008684
2Oxidative phosphorylation_Homo sapiens_hsa001903.25139421
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.96734744
4Parkinsons disease_Homo sapiens_hsa050122.79435141
5Cardiac muscle contraction_Homo sapiens_hsa042602.58276196
6RNA degradation_Homo sapiens_hsa030182.11691224
7Fanconi anemia pathway_Homo sapiens_hsa034602.07735238
8Huntingtons disease_Homo sapiens_hsa050162.07636832
9Sulfur relay system_Homo sapiens_hsa041221.99401456
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93747714
11RNA polymerase_Homo sapiens_hsa030201.92916914
12Asthma_Homo sapiens_hsa053101.91970396
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91758471
14Alzheimers disease_Homo sapiens_hsa050101.80425364
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79231455
16Steroid biosynthesis_Homo sapiens_hsa001001.78216855
17Homologous recombination_Homo sapiens_hsa034401.74241825
18Nicotine addiction_Homo sapiens_hsa050331.70785310
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.64623836
20Peroxisome_Homo sapiens_hsa041461.62637587
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60235732
22Fatty acid degradation_Homo sapiens_hsa000711.55467063
23Linoleic acid metabolism_Homo sapiens_hsa005911.55226644
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53292992
25Nucleotide excision repair_Homo sapiens_hsa034201.49601708
26Protein export_Homo sapiens_hsa030601.45922593
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.44006505
28Butanoate metabolism_Homo sapiens_hsa006501.38489825
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37763414
30Tryptophan metabolism_Homo sapiens_hsa003801.37173415
31Phototransduction_Homo sapiens_hsa047441.36253735
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35202515
33Propanoate metabolism_Homo sapiens_hsa006401.33013499
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26954259
35Dorso-ventral axis formation_Homo sapiens_hsa043201.26566530
36Fat digestion and absorption_Homo sapiens_hsa049751.23224209
37Basal transcription factors_Homo sapiens_hsa030221.22652355
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13117829
39Autoimmune thyroid disease_Homo sapiens_hsa053201.12986737
40Allograft rejection_Homo sapiens_hsa053301.11591221
41Basal cell carcinoma_Homo sapiens_hsa052171.04522520
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00722828
43Ether lipid metabolism_Homo sapiens_hsa005651.00579129
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00575727
45beta-Alanine metabolism_Homo sapiens_hsa004101.00570238
46Nitrogen metabolism_Homo sapiens_hsa009100.99825884
47Pyrimidine metabolism_Homo sapiens_hsa002400.99112271
48Olfactory transduction_Homo sapiens_hsa047400.94999059
49Glycerolipid metabolism_Homo sapiens_hsa005610.92410284
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90873441
51Proteasome_Homo sapiens_hsa030500.90540729
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87288855
53DNA replication_Homo sapiens_hsa030300.84348570
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83964629
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83391433
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.81196499
57Chemical carcinogenesis_Homo sapiens_hsa052040.81139481
58Sulfur metabolism_Homo sapiens_hsa009200.80891979
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79350972
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77566393
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77356909
62Morphine addiction_Homo sapiens_hsa050320.74112119
63Arginine and proline metabolism_Homo sapiens_hsa003300.73291496
64Retinol metabolism_Homo sapiens_hsa008300.73164324
65Mismatch repair_Homo sapiens_hsa034300.72273879
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72101970
67Starch and sucrose metabolism_Homo sapiens_hsa005000.68695119
68Caffeine metabolism_Homo sapiens_hsa002320.67363441
69Ovarian steroidogenesis_Homo sapiens_hsa049130.66609162
70Pyruvate metabolism_Homo sapiens_hsa006200.64251042
71RNA transport_Homo sapiens_hsa030130.63578743
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62641612
73Purine metabolism_Homo sapiens_hsa002300.62461878
74Metabolic pathways_Homo sapiens_hsa011000.61250610
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.57845923
76Hippo signaling pathway_Homo sapiens_hsa043900.53832239
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52327473
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49273135
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47976542
80Fatty acid metabolism_Homo sapiens_hsa012120.47360137
81Hedgehog signaling pathway_Homo sapiens_hsa043400.45713441
82Axon guidance_Homo sapiens_hsa043600.45296509
83Arachidonic acid metabolism_Homo sapiens_hsa005900.43660697
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43424614
85Insulin secretion_Homo sapiens_hsa049110.40527428
86Mineral absorption_Homo sapiens_hsa049780.40226068
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38114900
88GABAergic synapse_Homo sapiens_hsa047270.37559367
89Salivary secretion_Homo sapiens_hsa049700.37464864
90Primary immunodeficiency_Homo sapiens_hsa053400.32799931
91Synaptic vesicle cycle_Homo sapiens_hsa047210.27901754
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27723434
93Hematopoietic cell lineage_Homo sapiens_hsa046400.27402152
94Serotonergic synapse_Homo sapiens_hsa047260.26030807
95Melanoma_Homo sapiens_hsa052180.24952152
96Glutamatergic synapse_Homo sapiens_hsa047240.23715398
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.22538305
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22200780
99Selenocompound metabolism_Homo sapiens_hsa004500.18944686
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.18943293

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