

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | viral transcription (GO:0019083) | 8.54506077 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 8.51395596 |
| 3 | translational termination (GO:0006415) | 8.27088645 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 7.90297216 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.27425803 |
| 6 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.18577384 |
| 7 | cotranslational protein targeting to membrane (GO:0006613) | 7.11939503 |
| 8 | protein targeting to ER (GO:0045047) | 7.04065397 |
| 9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.77827766 |
| 10 | ATP synthesis coupled proton transport (GO:0015986) | 6.77827766 |
| 11 | translational elongation (GO:0006414) | 6.75770404 |
| 12 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 6.73968989 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 6.59050029 |
| 14 | maturation of SSU-rRNA (GO:0030490) | 6.30144193 |
| 15 | cellular protein complex disassembly (GO:0043624) | 6.24523738 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.22029464 |
| 17 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 6.16611538 |
| 18 | viral life cycle (GO:0019058) | 6.11377943 |
| 19 | translational initiation (GO:0006413) | 5.88394960 |
| 20 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.33654540 |
| 21 | regulation of mitochondrial translation (GO:0070129) | 5.30987013 |
| 22 | respiratory electron transport chain (GO:0022904) | 5.21215820 |
| 23 | protein complex disassembly (GO:0043241) | 5.21112216 |
| 24 | electron transport chain (GO:0022900) | 5.10764065 |
| 25 | ribosomal large subunit biogenesis (GO:0042273) | 5.06075154 |
| 26 | macromolecular complex disassembly (GO:0032984) | 4.99927246 |
| 27 | protein complex biogenesis (GO:0070271) | 4.94719887 |
| 28 | translation (GO:0006412) | 4.72710609 |
| 29 | chaperone-mediated protein transport (GO:0072321) | 4.72468346 |
| 30 | protein targeting to membrane (GO:0006612) | 4.66009283 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.60571210 |
| 32 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 4.44285361 |
| 33 | mRNA catabolic process (GO:0006402) | 4.17877976 |
| 34 | inner mitochondrial membrane organization (GO:0007007) | 4.17679612 |
| 35 | cytochrome complex assembly (GO:0017004) | 4.15133607 |
| 36 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.08486998 |
| 37 | NADH dehydrogenase complex assembly (GO:0010257) | 4.08486998 |
| 38 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.08486998 |
| 39 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 4.05370080 |
| 40 | ATP biosynthetic process (GO:0006754) | 4.02877116 |
| 41 | rRNA modification (GO:0000154) | 3.99237549 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.79831335 |
| 43 | maturation of 5.8S rRNA (GO:0000460) | 3.78903175 |
| 44 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.76084351 |
| 45 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.75941798 |
| 46 | positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517) | 3.75106970 |
| 47 | RNA catabolic process (GO:0006401) | 3.74997720 |
| 48 | cellular component biogenesis (GO:0044085) | 3.70276362 |
| 49 | protein neddylation (GO:0045116) | 3.66022423 |
| 50 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.61412261 |
| 51 | respiratory chain complex IV assembly (GO:0008535) | 3.50288410 |
| 52 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.50040477 |
| 53 | hydrogen ion transmembrane transport (GO:1902600) | 3.48190790 |
| 54 | RNA localization (GO:0006403) | 3.47491377 |
| 55 | rRNA processing (GO:0006364) | 3.41130457 |
| 56 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.40825215 |
| 57 | sequestering of actin monomers (GO:0042989) | 3.35780824 |
| 58 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.34521892 |
| 59 | rRNA metabolic process (GO:0016072) | 3.31217631 |
| 60 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.25184398 |
| 61 | chromatin remodeling at centromere (GO:0031055) | 3.21918189 |
| 62 | CENP-A containing nucleosome assembly (GO:0034080) | 3.18858297 |
| 63 | establishment of protein localization to membrane (GO:0090150) | 3.18335591 |
| 64 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 3.17658011 |
| 65 | behavioral response to nicotine (GO:0035095) | 3.14679892 |
| 66 | proton transport (GO:0015992) | 3.10447804 |
| 67 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 3.09933441 |
| 68 | spliceosomal snRNP assembly (GO:0000387) | 3.04894208 |
| 69 | hydrogen transport (GO:0006818) | 3.02533687 |
| 70 | intracellular protein transmembrane import (GO:0044743) | 3.01448505 |
| 71 | protein targeting (GO:0006605) | 3.01134655 |
| 72 | establishment of protein localization to organelle (GO:0072594) | 3.00019532 |
| 73 | rRNA methylation (GO:0031167) | 2.94525443 |
| 74 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.93517228 |
| 75 | positive regulation of translational initiation (GO:0045948) | 2.91987486 |
| 76 | GTP biosynthetic process (GO:0006183) | 2.91240594 |
| 77 | termination of RNA polymerase III transcription (GO:0006386) | 2.89051352 |
| 78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.89051352 |
| 79 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 2.88777278 |
| 80 | organelle disassembly (GO:1903008) | 2.87978033 |
| 81 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.86212957 |
| 82 | proteasome assembly (GO:0043248) | 2.83721733 |
| 83 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.77433135 |
| 84 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.77433135 |
| 85 | establishment of protein localization to mitochondrion (GO:0072655) | 2.76270347 |
| 86 | positive regulation of signal transduction by p53 class mediator (GO:1901798) | 2.73335382 |
| 87 | DNA deamination (GO:0045006) | 2.69213378 |
| 88 | otic vesicle formation (GO:0030916) | 2.67198085 |
| 89 | spliceosomal complex assembly (GO:0000245) | 2.65942935 |
| 90 | histone exchange (GO:0043486) | 2.65384821 |
| 91 | oxidative phosphorylation (GO:0006119) | 2.65268179 |
| 92 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.64440880 |
| 93 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.64440880 |
| 94 | peptidyl-histidine modification (GO:0018202) | 2.62771449 |
| 95 | DNA replication checkpoint (GO:0000076) | 2.61168667 |
| 96 | epithelial cilium movement (GO:0003351) | 2.55102091 |
| 97 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.55087524 |
| 98 | signal peptide processing (GO:0006465) | 2.54775581 |
| 99 | protein localization to mitochondrion (GO:0070585) | 2.53663886 |
| 100 | lateral sprouting from an epithelium (GO:0060601) | 2.53645784 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.47876146 |
| 2 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.38435467 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.30720001 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.85196841 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.34041649 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.31122149 |
| 7 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.90952463 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.85742362 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.84628677 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.70717672 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.63713779 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.54216256 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.47996659 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38452726 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.20090947 |
| 16 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.18918556 |
| 17 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.10929711 |
| 18 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.02623849 |
| 19 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.02014305 |
| 20 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.96371012 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.94407354 |
| 22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.92106888 |
| 23 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.85707624 |
| 24 | EWS_26573619_Chip-Seq_HEK293_Human | 1.83966620 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.79644974 |
| 26 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.70827476 |
| 27 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.68604003 |
| 28 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.67799215 |
| 29 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.65756394 |
| 30 | FUS_26573619_Chip-Seq_HEK293_Human | 1.65326738 |
| 31 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.63741996 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.62777459 |
| 33 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.62042617 |
| 34 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.57988450 |
| 35 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.53952355 |
| 36 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.46684753 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.45913316 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.45879740 |
| 39 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.44225106 |
| 40 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.43660732 |
| 41 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.42787781 |
| 42 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.42163823 |
| 43 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.36943198 |
| 44 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.36836111 |
| 45 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.36238943 |
| 46 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.35363679 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31349943 |
| 48 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.29122581 |
| 49 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.28525988 |
| 50 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.26015167 |
| 51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.24718746 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.24442335 |
| 53 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.23510578 |
| 54 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.23125184 |
| 55 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.21493123 |
| 56 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20509071 |
| 57 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.20458083 |
| 58 | P300_19829295_ChIP-Seq_ESCs_Human | 1.18539124 |
| 59 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.17362488 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.17152703 |
| 61 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.10664665 |
| 62 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.09895723 |
| 63 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.08379288 |
| 64 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.06065051 |
| 65 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06065051 |
| 66 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05937302 |
| 67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05325856 |
| 68 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.05074953 |
| 69 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.01297667 |
| 70 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.00660113 |
| 71 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.99553198 |
| 72 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.98036141 |
| 73 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.97797584 |
| 74 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97250618 |
| 75 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.95410306 |
| 76 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94161029 |
| 77 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93514070 |
| 78 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93514070 |
| 79 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.91964308 |
| 80 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.91212216 |
| 81 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.90930651 |
| 82 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.90168870 |
| 83 | NCOR_22424771_ChIP-Seq_293T_Human | 0.89436555 |
| 84 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.89298807 |
| 85 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.87806764 |
| 86 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.87266899 |
| 87 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.87225253 |
| 88 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.85707970 |
| 89 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.85111630 |
| 90 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.84449518 |
| 91 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.83904478 |
| 92 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.83492211 |
| 93 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.83403967 |
| 94 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.82149410 |
| 95 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.81895525 |
| 96 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81856474 |
| 97 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81856474 |
| 98 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.81637942 |
| 99 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.81147115 |
| 100 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.80843901 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 5.92132213 |
| 2 | MP0006292_abnormal_olfactory_placode | 4.53078749 |
| 3 | MP0003136_yellow_coat_color | 3.15798742 |
| 4 | MP0002938_white_spotting | 3.11340341 |
| 5 | MP0003011_delayed_dark_adaptation | 2.71258600 |
| 6 | MP0001293_anophthalmia | 2.22268676 |
| 7 | MP0005084_abnormal_gallbladder_morpholo | 2.19270838 |
| 8 | MP0002277_abnormal_respiratory_mucosa | 2.17344428 |
| 9 | MP0004142_abnormal_muscle_tone | 2.10924770 |
| 10 | MP0002102_abnormal_ear_morphology | 2.03323042 |
| 11 | MP0008058_abnormal_DNA_repair | 2.01766753 |
| 12 | MP0000566_synostosis | 1.97947151 |
| 13 | MP0010030_abnormal_orbit_morphology | 1.94656627 |
| 14 | MP0002163_abnormal_gland_morphology | 1.92502752 |
| 15 | MP0002638_abnormal_pupillary_reflex | 1.88235721 |
| 16 | MP0003646_muscle_fatigue | 1.81697521 |
| 17 | MP0000372_irregular_coat_pigmentation | 1.72228861 |
| 18 | MP0001529_abnormal_vocalization | 1.71313705 |
| 19 | MP0003938_abnormal_ear_development | 1.62616519 |
| 20 | MP0004957_abnormal_blastocyst_morpholog | 1.58550587 |
| 21 | MP0003186_abnormal_redox_activity | 1.57051791 |
| 22 | MP0000049_abnormal_middle_ear | 1.51745443 |
| 23 | MP0008995_early_reproductive_senescence | 1.47021967 |
| 24 | MP0004145_abnormal_muscle_electrophysio | 1.46433740 |
| 25 | MP0000631_abnormal_neuroendocrine_gland | 1.44466183 |
| 26 | MP0002736_abnormal_nociception_after | 1.42129980 |
| 27 | MP0005551_abnormal_eye_electrophysiolog | 1.41209297 |
| 28 | MP0003718_maternal_effect | 1.40348766 |
| 29 | MP0006072_abnormal_retinal_apoptosis | 1.39554574 |
| 30 | MP0003941_abnormal_skin_development | 1.38648335 |
| 31 | MP0002822_catalepsy | 1.36985097 |
| 32 | MP0003937_abnormal_limbs/digits/tail_de | 1.32879818 |
| 33 | MP0003880_abnormal_central_pattern | 1.32787778 |
| 34 | MP0008877_abnormal_DNA_methylation | 1.32062717 |
| 35 | MP0003890_abnormal_embryonic-extraembry | 1.31859961 |
| 36 | MP0001485_abnormal_pinna_reflex | 1.30079685 |
| 37 | MP0004885_abnormal_endolymph | 1.27213638 |
| 38 | MP0004133_heterotaxia | 1.27047929 |
| 39 | MP0003693_abnormal_embryo_hatching | 1.22197543 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.20230418 |
| 41 | MP0009745_abnormal_behavioral_response | 1.19121761 |
| 42 | MP0008789_abnormal_olfactory_epithelium | 1.17631605 |
| 43 | MP0002735_abnormal_chemical_nociception | 1.15398592 |
| 44 | MP0008875_abnormal_xenobiotic_pharmacok | 1.14977580 |
| 45 | MP0001286_abnormal_eye_development | 1.12403717 |
| 46 | MP0006035_abnormal_mitochondrial_morpho | 1.09474396 |
| 47 | MP0005253_abnormal_eye_physiology | 1.07777876 |
| 48 | MP0001968_abnormal_touch/_nociception | 1.06232257 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.05797981 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 1.05266008 |
| 51 | MP0003567_abnormal_fetal_cardiomyocyte | 1.04285060 |
| 52 | MP0005379_endocrine/exocrine_gland_phen | 1.04184981 |
| 53 | MP0003806_abnormal_nucleotide_metabolis | 1.02738835 |
| 54 | MP0003315_abnormal_perineum_morphology | 1.02366459 |
| 55 | MP0009250_abnormal_appendicular_skeleto | 1.02255445 |
| 56 | MP0002160_abnormal_reproductive_system | 1.02249230 |
| 57 | MP0002234_abnormal_pharynx_morphology | 1.02011606 |
| 58 | MP0004742_abnormal_vestibular_system | 1.00582199 |
| 59 | MP0005187_abnormal_penis_morphology | 0.99651503 |
| 60 | MP0002210_abnormal_sex_determination | 0.99442753 |
| 61 | MP0002653_abnormal_ependyma_morphology | 0.96159987 |
| 62 | MP0000778_abnormal_nervous_system | 0.95927805 |
| 63 | MP0005410_abnormal_fertilization | 0.94000858 |
| 64 | MP0002697_abnormal_eye_size | 0.93371038 |
| 65 | MP0001984_abnormal_olfaction | 0.91452559 |
| 66 | MP0005391_vision/eye_phenotype | 0.89221724 |
| 67 | MP0000026_abnormal_inner_ear | 0.87535210 |
| 68 | MP0003787_abnormal_imprinting | 0.87374029 |
| 69 | MP0003878_abnormal_ear_physiology | 0.87334370 |
| 70 | MP0005377_hearing/vestibular/ear_phenot | 0.87334370 |
| 71 | MP0003283_abnormal_digestive_organ | 0.86040202 |
| 72 | MP0008872_abnormal_physiological_respon | 0.85984217 |
| 73 | MP0003122_maternal_imprinting | 0.85895974 |
| 74 | MP0002557_abnormal_social/conspecific_i | 0.85669365 |
| 75 | MP0002928_abnormal_bile_duct | 0.85602357 |
| 76 | MP0003786_premature_aging | 0.85226684 |
| 77 | MP0005389_reproductive_system_phenotype | 0.85206292 |
| 78 | MP0005195_abnormal_posterior_eye | 0.85127688 |
| 79 | MP0000653_abnormal_sex_gland | 0.84887927 |
| 80 | MP0001905_abnormal_dopamine_level | 0.84313356 |
| 81 | MP0002876_abnormal_thyroid_physiology | 0.84167072 |
| 82 | MP0002184_abnormal_innervation | 0.83886753 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.82793404 |
| 84 | MP0002282_abnormal_trachea_morphology | 0.82465759 |
| 85 | MP0002233_abnormal_nose_morphology | 0.81007816 |
| 86 | MP0003936_abnormal_reproductive_system | 0.80322241 |
| 87 | MP0002734_abnormal_mechanical_nocicepti | 0.80092732 |
| 88 | MP0002095_abnormal_skin_pigmentation | 0.79796682 |
| 89 | MP0001881_abnormal_mammary_gland | 0.79327668 |
| 90 | MP0003119_abnormal_digestive_system | 0.78841538 |
| 91 | MP0005394_taste/olfaction_phenotype | 0.77892388 |
| 92 | MP0005499_abnormal_olfactory_system | 0.77892388 |
| 93 | MP0003121_genomic_imprinting | 0.77782269 |
| 94 | MP0001486_abnormal_startle_reflex | 0.77533686 |
| 95 | MP0004147_increased_porphyrin_level | 0.77383141 |
| 96 | MP0001970_abnormal_pain_threshold | 0.77056328 |
| 97 | MP0001145_abnormal_male_reproductive | 0.76707800 |
| 98 | MP0002272_abnormal_nervous_system | 0.76108341 |
| 99 | MP0003195_calcinosis | 0.73580993 |
| 100 | MP0003942_abnormal_urinary_system | 0.73173639 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 5.34833537 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.18404221 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.77518789 |
| 4 | Macrocytic anemia (HP:0001972) | 4.54747801 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 4.52574411 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.47867168 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.39459578 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.37532091 |
| 9 | Acute encephalopathy (HP:0006846) | 4.35047529 |
| 10 | Progressive macrocephaly (HP:0004481) | 4.28421836 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.03197065 |
| 12 | Increased CSF lactate (HP:0002490) | 3.87179394 |
| 13 | Renal Fanconi syndrome (HP:0001994) | 3.60196949 |
| 14 | Septo-optic dysplasia (HP:0100842) | 3.46488859 |
| 15 | Cerebral edema (HP:0002181) | 3.43829785 |
| 16 | Congenital, generalized hypertrichosis (HP:0004540) | 3.34406582 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.29291703 |
| 18 | Pallor (HP:0000980) | 3.23627990 |
| 19 | Colon cancer (HP:0003003) | 3.17182968 |
| 20 | Aplastic anemia (HP:0001915) | 3.14778062 |
| 21 | Hepatic necrosis (HP:0002605) | 2.99104516 |
| 22 | Concave nail (HP:0001598) | 2.93538544 |
| 23 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.89512701 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 2.87798467 |
| 25 | Exertional dyspnea (HP:0002875) | 2.82910099 |
| 26 | Pancreatic fibrosis (HP:0100732) | 2.71251736 |
| 27 | Stenosis of the external auditory canal (HP:0000402) | 2.70091257 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.64165785 |
| 29 | Optic disc pallor (HP:0000543) | 2.63991570 |
| 30 | Abnormality of renal resorption (HP:0011038) | 2.51862939 |
| 31 | Pancreatic cysts (HP:0001737) | 2.47222512 |
| 32 | Oral leukoplakia (HP:0002745) | 2.47146355 |
| 33 | Partial duplication of thumb phalanx (HP:0009944) | 2.46950711 |
| 34 | Leukodystrophy (HP:0002415) | 2.42888275 |
| 35 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.41505715 |
| 36 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.41505715 |
| 37 | Abnormality of midbrain morphology (HP:0002418) | 2.40874754 |
| 38 | Molar tooth sign on MRI (HP:0002419) | 2.40874754 |
| 39 | Methylmalonic acidemia (HP:0002912) | 2.40728395 |
| 40 | True hermaphroditism (HP:0010459) | 2.37960929 |
| 41 | Pendular nystagmus (HP:0012043) | 2.36878551 |
| 42 | Absent septum pellucidum (HP:0001331) | 2.36008226 |
| 43 | Abnormality of the labia minora (HP:0012880) | 2.34687706 |
| 44 | Supernumerary spleens (HP:0009799) | 2.32040043 |
| 45 | Respiratory difficulties (HP:0002880) | 2.31942963 |
| 46 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.31346359 |
| 47 | Congenital stationary night blindness (HP:0007642) | 2.31069993 |
| 48 | Glycosuria (HP:0003076) | 2.29711997 |
| 49 | Abnormality of urine glucose concentration (HP:0011016) | 2.29711997 |
| 50 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.28645298 |
| 51 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.28645298 |
| 52 | Abnormal ciliary motility (HP:0012262) | 2.26442236 |
| 53 | Respiratory failure (HP:0002878) | 2.22666157 |
| 54 | Medial flaring of the eyebrow (HP:0010747) | 2.22400055 |
| 55 | Absent/shortened dynein arms (HP:0200106) | 2.22041817 |
| 56 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.22041817 |
| 57 | Increased serum lactate (HP:0002151) | 2.21763340 |
| 58 | Nephronophthisis (HP:0000090) | 2.20423808 |
| 59 | Exercise intolerance (HP:0003546) | 2.20056352 |
| 60 | Partial duplication of the phalanx of hand (HP:0009999) | 2.18672707 |
| 61 | Lactic acidosis (HP:0003128) | 2.17733161 |
| 62 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.10952062 |
| 63 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.10417127 |
| 64 | Lethargy (HP:0001254) | 2.07580006 |
| 65 | Increased muscle lipid content (HP:0009058) | 2.07202955 |
| 66 | Abnormal number of incisors (HP:0011064) | 2.06955012 |
| 67 | Depressed nasal ridge (HP:0000457) | 2.03863929 |
| 68 | Hyperglycinemia (HP:0002154) | 2.02722991 |
| 69 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.02081787 |
| 70 | Maternal diabetes (HP:0009800) | 2.01890053 |
| 71 | Methylmalonic aciduria (HP:0012120) | 2.00297127 |
| 72 | Hyperphosphaturia (HP:0003109) | 1.98615915 |
| 73 | Triphalangeal thumb (HP:0001199) | 1.97655948 |
| 74 | Myokymia (HP:0002411) | 1.96014100 |
| 75 | Abnormality of the septum pellucidum (HP:0007375) | 1.93620579 |
| 76 | Rhinitis (HP:0012384) | 1.91616878 |
| 77 | Anencephaly (HP:0002323) | 1.87174909 |
| 78 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.85025645 |
| 79 | Anophthalmia (HP:0000528) | 1.83237509 |
| 80 | Abnormality of the renal medulla (HP:0100957) | 1.82515155 |
| 81 | Absent thumb (HP:0009777) | 1.82186803 |
| 82 | Optic nerve hypoplasia (HP:0000609) | 1.81045431 |
| 83 | Esophageal atresia (HP:0002032) | 1.81031689 |
| 84 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.80402554 |
| 85 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.80280963 |
| 86 | Cerebral hypomyelination (HP:0006808) | 1.79149220 |
| 87 | Bilateral microphthalmos (HP:0007633) | 1.77717086 |
| 88 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.76286758 |
| 89 | Degeneration of anterior horn cells (HP:0002398) | 1.75215664 |
| 90 | Abnormality of the anterior horn cell (HP:0006802) | 1.75215664 |
| 91 | Hypoplasia of the radius (HP:0002984) | 1.75057548 |
| 92 | Asplenia (HP:0001746) | 1.74222702 |
| 93 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.73461234 |
| 94 | Sclerocornea (HP:0000647) | 1.70541904 |
| 95 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.70487031 |
| 96 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.70487031 |
| 97 | Abnormality of the pons (HP:0007361) | 1.69444504 |
| 98 | Pancytopenia (HP:0001876) | 1.67914265 |
| 99 | Hypoplasia of the pons (HP:0012110) | 1.65910502 |
| 100 | Cleft eyelid (HP:0000625) | 1.63764428 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.65856556 |
| 2 | STK16 | 2.59451998 |
| 3 | TAF1 | 2.56189737 |
| 4 | ZAK | 2.55245460 |
| 5 | RIPK1 | 2.43345396 |
| 6 | BMPR1B | 2.37728780 |
| 7 | VRK1 | 2.36177969 |
| 8 | PASK | 2.35616469 |
| 9 | CDC7 | 2.27585479 |
| 10 | TNIK | 2.22993655 |
| 11 | MAP4K2 | 2.15489237 |
| 12 | BUB1 | 2.14074341 |
| 13 | NEK1 | 2.13676111 |
| 14 | DYRK2 | 2.13501625 |
| 15 | STK24 | 2.03189791 |
| 16 | NME1 | 1.94364552 |
| 17 | WNK3 | 1.89811928 |
| 18 | GRK1 | 1.88685977 |
| 19 | PNCK | 1.85625212 |
| 20 | ADRBK2 | 1.76990292 |
| 21 | DYRK3 | 1.75400180 |
| 22 | NUAK1 | 1.70347675 |
| 23 | PRKCI | 1.69549673 |
| 24 | PBK | 1.67047698 |
| 25 | WNK4 | 1.65645157 |
| 26 | PLK3 | 1.60344770 |
| 27 | PRKCG | 1.50155811 |
| 28 | EIF2AK3 | 1.47058764 |
| 29 | TLK1 | 1.40341124 |
| 30 | PINK1 | 1.33203736 |
| 31 | PDK2 | 1.32481144 |
| 32 | PLK4 | 1.32427824 |
| 33 | EPHB2 | 1.31120590 |
| 34 | SRPK1 | 1.30806977 |
| 35 | WEE1 | 1.29660187 |
| 36 | TTK | 1.27916324 |
| 37 | FRK | 1.22855712 |
| 38 | MAP3K12 | 1.11485332 |
| 39 | FGFR2 | 1.10631224 |
| 40 | BCKDK | 1.06202313 |
| 41 | TIE1 | 1.03461149 |
| 42 | MST4 | 1.02261038 |
| 43 | TXK | 1.00314697 |
| 44 | NME2 | 0.99588634 |
| 45 | BRSK2 | 0.98094364 |
| 46 | NLK | 0.97324017 |
| 47 | TSSK6 | 0.95815182 |
| 48 | CDK19 | 0.94921858 |
| 49 | TGFBR1 | 0.90941196 |
| 50 | PLK1 | 0.90573401 |
| 51 | DAPK3 | 0.90560097 |
| 52 | TAOK3 | 0.90378468 |
| 53 | INSRR | 0.89950568 |
| 54 | ACVR1B | 0.84567172 |
| 55 | MKNK1 | 0.82240736 |
| 56 | PRKCE | 0.78325625 |
| 57 | MKNK2 | 0.77444001 |
| 58 | STK38L | 0.76308809 |
| 59 | TRIM28 | 0.76107682 |
| 60 | CDK8 | 0.75246367 |
| 61 | CSNK2A2 | 0.73656658 |
| 62 | EPHA4 | 0.73419094 |
| 63 | AURKB | 0.72876110 |
| 64 | LRRK2 | 0.72720326 |
| 65 | CHEK2 | 0.72320159 |
| 66 | STK4 | 0.72301676 |
| 67 | BRSK1 | 0.68649959 |
| 68 | FGFR1 | 0.67218615 |
| 69 | CSNK2A1 | 0.64621580 |
| 70 | ADRBK1 | 0.63205356 |
| 71 | ILK | 0.62978909 |
| 72 | CASK | 0.60047119 |
| 73 | MAP3K4 | 0.59844917 |
| 74 | PAK3 | 0.56398563 |
| 75 | MAP2K7 | 0.53041597 |
| 76 | OBSCN | 0.52856927 |
| 77 | FLT3 | 0.52796673 |
| 78 | CAMK1 | 0.52668541 |
| 79 | MAP4K1 | 0.51789018 |
| 80 | PRKCQ | 0.50133486 |
| 81 | MAPK15 | 0.46110661 |
| 82 | ATR | 0.44742864 |
| 83 | PRKCD | 0.43032236 |
| 84 | PRKACA | 0.42946022 |
| 85 | STK39 | 0.41406760 |
| 86 | MARK1 | 0.41103401 |
| 87 | OXSR1 | 0.40604650 |
| 88 | STK3 | 0.38413030 |
| 89 | CSNK1E | 0.37596842 |
| 90 | AURKA | 0.36279715 |
| 91 | MAP3K9 | 0.35650072 |
| 92 | RPS6KA5 | 0.34533428 |
| 93 | DYRK1A | 0.33792384 |
| 94 | TEC | 0.33432083 |
| 95 | WNK1 | 0.33203802 |
| 96 | CSNK1A1 | 0.31690376 |
| 97 | CSNK1G1 | 0.31050809 |
| 98 | PLK2 | 0.30816873 |
| 99 | ATM | 0.29693402 |
| 100 | PRKG1 | 0.28076585 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 6.82129041 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.94161259 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.30587181 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.16895529 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 3.13894096 |
| 6 | Alzheimers disease_Homo sapiens_hsa05010 | 2.86815801 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.74284708 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.66057558 |
| 9 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.52919813 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.28036862 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 1.96670589 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 1.80951083 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 1.80338848 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.76294700 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.61651109 |
| 16 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.60858401 |
| 17 | DNA replication_Homo sapiens_hsa03030 | 1.59586597 |
| 18 | Spliceosome_Homo sapiens_hsa03040 | 1.49080529 |
| 19 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.41665180 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.41388539 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.35780222 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.23351597 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.15877015 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11844058 |
| 25 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.09813584 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.05661007 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.05634184 |
| 28 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.04147167 |
| 29 | Phototransduction_Homo sapiens_hsa04744 | 1.03249576 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.02642957 |
| 31 | Nicotine addiction_Homo sapiens_hsa05033 | 1.00556259 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.96587759 |
| 33 | Sulfur relay system_Homo sapiens_hsa04122 | 0.94885049 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 0.94466463 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.90118967 |
| 36 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.89149305 |
| 37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.86390872 |
| 38 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.86279281 |
| 39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.85112000 |
| 40 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82398008 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.82201195 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.81558743 |
| 43 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.79160989 |
| 44 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.74717218 |
| 45 | Mineral absorption_Homo sapiens_hsa04978 | 0.73712530 |
| 46 | Olfactory transduction_Homo sapiens_hsa04740 | 0.73471521 |
| 47 | Metabolic pathways_Homo sapiens_hsa01100 | 0.73073790 |
| 48 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.72996830 |
| 49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.72762350 |
| 50 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.72254864 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.71036370 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.70187239 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69953685 |
| 54 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.68767104 |
| 55 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67434675 |
| 56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.66215025 |
| 57 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.65710789 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.65534850 |
| 59 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.63659254 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.61419172 |
| 61 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.59792448 |
| 62 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.59542528 |
| 63 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59073776 |
| 64 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.58464193 |
| 65 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.57070365 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.56913563 |
| 67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.55758942 |
| 68 | Taste transduction_Homo sapiens_hsa04742 | 0.55592463 |
| 69 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.49184248 |
| 70 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.46774955 |
| 71 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45144637 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.43986502 |
| 73 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.42975259 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41907003 |
| 75 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41780173 |
| 76 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38891920 |
| 77 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37621830 |
| 78 | Morphine addiction_Homo sapiens_hsa05032 | 0.36658988 |
| 79 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.35942806 |
| 80 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.34560577 |
| 81 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.32597335 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.31794620 |
| 83 | Cell cycle_Homo sapiens_hsa04110 | 0.30310823 |
| 84 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.29293261 |
| 85 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.28627749 |
| 86 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.25712015 |
| 87 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.24233915 |
| 88 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.23357421 |
| 89 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22950107 |
| 90 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.22069897 |
| 91 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.21877011 |
| 92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.21131800 |
| 93 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.18921272 |
| 94 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.17284594 |
| 95 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.16453213 |
| 96 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.16115163 |
| 97 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.15478691 |
| 98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.14778299 |
| 99 | GABAergic synapse_Homo sapiens_hsa04727 | 0.14752549 |
| 100 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.14175429 |

