RPSAP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.54506077
2ribosomal small subunit assembly (GO:0000028)8.51395596
3translational termination (GO:0006415)8.27088645
4ribosomal small subunit biogenesis (GO:0042274)7.90297216
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.27425803
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.18577384
7cotranslational protein targeting to membrane (GO:0006613)7.11939503
8protein targeting to ER (GO:0045047)7.04065397
9energy coupled proton transport, down electrochemical gradient (GO:0015985)6.77827766
10ATP synthesis coupled proton transport (GO:0015986)6.77827766
11translational elongation (GO:0006414)6.75770404
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.73968989
13protein localization to endoplasmic reticulum (GO:0070972)6.59050029
14maturation of SSU-rRNA (GO:0030490)6.30144193
15cellular protein complex disassembly (GO:0043624)6.24523738
16establishment of protein localization to mitochondrial membrane (GO:0090151)6.22029464
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.16611538
18viral life cycle (GO:0019058)6.11377943
19translational initiation (GO:0006413)5.88394960
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.33654540
21regulation of mitochondrial translation (GO:0070129)5.30987013
22respiratory electron transport chain (GO:0022904)5.21215820
23protein complex disassembly (GO:0043241)5.21112216
24electron transport chain (GO:0022900)5.10764065
25ribosomal large subunit biogenesis (GO:0042273)5.06075154
26macromolecular complex disassembly (GO:0032984)4.99927246
27protein complex biogenesis (GO:0070271)4.94719887
28translation (GO:0006412)4.72710609
29chaperone-mediated protein transport (GO:0072321)4.72468346
30protein targeting to membrane (GO:0006612)4.66009283
31mitochondrial respiratory chain complex assembly (GO:0033108)4.60571210
32nuclear-transcribed mRNA catabolic process (GO:0000956)4.44285361
33mRNA catabolic process (GO:0006402)4.17877976
34inner mitochondrial membrane organization (GO:0007007)4.17679612
35cytochrome complex assembly (GO:0017004)4.15133607
36mitochondrial respiratory chain complex I assembly (GO:0032981)4.08486998
37NADH dehydrogenase complex assembly (GO:0010257)4.08486998
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08486998
39negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.05370080
40ATP biosynthetic process (GO:0006754)4.02877116
41rRNA modification (GO:0000154)3.99237549
42pseudouridine synthesis (GO:0001522)3.79831335
43maturation of 5.8S rRNA (GO:0000460)3.78903175
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.76084351
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.75941798
46positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.75106970
47RNA catabolic process (GO:0006401)3.74997720
48cellular component biogenesis (GO:0044085)3.70276362
49protein neddylation (GO:0045116)3.66022423
50water-soluble vitamin biosynthetic process (GO:0042364)3.61412261
51respiratory chain complex IV assembly (GO:0008535)3.50288410
52ribonucleoprotein complex biogenesis (GO:0022613)3.50040477
53hydrogen ion transmembrane transport (GO:1902600)3.48190790
54RNA localization (GO:0006403)3.47491377
55rRNA processing (GO:0006364)3.41130457
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40825215
57sequestering of actin monomers (GO:0042989)3.35780824
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34521892
59rRNA metabolic process (GO:0016072)3.31217631
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.25184398
61chromatin remodeling at centromere (GO:0031055)3.21918189
62CENP-A containing nucleosome assembly (GO:0034080)3.18858297
63establishment of protein localization to membrane (GO:0090150)3.18335591
64regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.17658011
65behavioral response to nicotine (GO:0035095)3.14679892
66proton transport (GO:0015992)3.10447804
67negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.09933441
68spliceosomal snRNP assembly (GO:0000387)3.04894208
69hydrogen transport (GO:0006818)3.02533687
70intracellular protein transmembrane import (GO:0044743)3.01448505
71protein targeting (GO:0006605)3.01134655
72establishment of protein localization to organelle (GO:0072594)3.00019532
73rRNA methylation (GO:0031167)2.94525443
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93517228
75positive regulation of translational initiation (GO:0045948)2.91987486
76GTP biosynthetic process (GO:0006183)2.91240594
77termination of RNA polymerase III transcription (GO:0006386)2.89051352
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.89051352
79regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.88777278
80organelle disassembly (GO:1903008)2.87978033
81nucleoside triphosphate biosynthetic process (GO:0009142)2.86212957
82proteasome assembly (GO:0043248)2.83721733
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77433135
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77433135
85establishment of protein localization to mitochondrion (GO:0072655)2.76270347
86positive regulation of signal transduction by p53 class mediator (GO:1901798)2.73335382
87DNA deamination (GO:0045006)2.69213378
88otic vesicle formation (GO:0030916)2.67198085
89spliceosomal complex assembly (GO:0000245)2.65942935
90histone exchange (GO:0043486)2.65384821
91oxidative phosphorylation (GO:0006119)2.65268179
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.64440880
93purine nucleoside monophosphate biosynthetic process (GO:0009127)2.64440880
94peptidyl-histidine modification (GO:0018202)2.62771449
95DNA replication checkpoint (GO:0000076)2.61168667
96epithelial cilium movement (GO:0003351)2.55102091
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55087524
98signal peptide processing (GO:0006465)2.54775581
99protein localization to mitochondrion (GO:0070585)2.53663886
100lateral sprouting from an epithelium (GO:0060601)2.53645784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47876146
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.38435467
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30720001
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85196841
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.34041649
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.31122149
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.90952463
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.85742362
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84628677
10VDR_22108803_ChIP-Seq_LS180_Human2.70717672
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63713779
12ELK1_19687146_ChIP-ChIP_HELA_Human2.54216256
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47996659
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38452726
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20090947
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18918556
17ZNF274_21170338_ChIP-Seq_K562_Hela2.10929711
18MYC_18940864_ChIP-ChIP_HL60_Human2.02623849
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.02014305
20TTF2_22483619_ChIP-Seq_HELA_Human1.96371012
21VDR_23849224_ChIP-Seq_CD4+_Human1.94407354
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.92106888
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85707624
24EWS_26573619_Chip-Seq_HEK293_Human1.83966620
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.79644974
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70827476
27XRN2_22483619_ChIP-Seq_HELA_Human1.68604003
28EZH2_22144423_ChIP-Seq_EOC_Human1.67799215
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65756394
30FUS_26573619_Chip-Seq_HEK293_Human1.65326738
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63741996
32FOXP3_21729870_ChIP-Seq_TREG_Human1.62777459
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62042617
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57988450
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53952355
36RNF2_27304074_Chip-Seq_NSC_Mouse1.46684753
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45913316
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.45879740
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44225106
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.43660732
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42787781
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.42163823
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.36943198
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36836111
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36238943
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35363679
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31349943
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29122581
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28525988
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26015167
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24718746
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.24442335
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.23510578
54IGF1R_20145208_ChIP-Seq_DFB_Human1.23125184
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21493123
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20509071
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20458083
58P300_19829295_ChIP-Seq_ESCs_Human1.18539124
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17362488
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17152703
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.10664665
62DCP1A_22483619_ChIP-Seq_HELA_Human1.09895723
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08379288
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06065051
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06065051
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05937302
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05325856
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05074953
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.01297667
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00660113
71SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99553198
72ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98036141
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97797584
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97250618
75SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95410306
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94161029
77SOX2_19829295_ChIP-Seq_ESCs_Human0.93514070
78NANOG_19829295_ChIP-Seq_ESCs_Human0.93514070
79TAF15_26573619_Chip-Seq_HEK293_Human0.91964308
80AR_21572438_ChIP-Seq_LNCaP_Human0.91212216
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90930651
82GABP_19822575_ChIP-Seq_HepG2_Human0.90168870
83NCOR_22424771_ChIP-Seq_293T_Human0.89436555
84TP53_22573176_ChIP-Seq_HFKS_Human0.89298807
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.87806764
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87266899
87RBPJ_21746931_ChIP-Seq_IB4_Human0.87225253
88ETV1_20927104_ChIP-Seq_GIST48_Human0.85707970
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85111630
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.84449518
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83904478
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83492211
93PHF8_20622853_ChIP-Seq_HELA_Human0.83403967
94IRF1_19129219_ChIP-ChIP_H3396_Human0.82149410
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81895525
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.81856474
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81856474
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81637942
99ER_23166858_ChIP-Seq_MCF-7_Human0.81147115
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.80843901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.92132213
2MP0006292_abnormal_olfactory_placode4.53078749
3MP0003136_yellow_coat_color3.15798742
4MP0002938_white_spotting3.11340341
5MP0003011_delayed_dark_adaptation2.71258600
6MP0001293_anophthalmia2.22268676
7MP0005084_abnormal_gallbladder_morpholo2.19270838
8MP0002277_abnormal_respiratory_mucosa2.17344428
9MP0004142_abnormal_muscle_tone2.10924770
10MP0002102_abnormal_ear_morphology2.03323042
11MP0008058_abnormal_DNA_repair2.01766753
12MP0000566_synostosis1.97947151
13MP0010030_abnormal_orbit_morphology1.94656627
14MP0002163_abnormal_gland_morphology1.92502752
15MP0002638_abnormal_pupillary_reflex1.88235721
16MP0003646_muscle_fatigue1.81697521
17MP0000372_irregular_coat_pigmentation1.72228861
18MP0001529_abnormal_vocalization1.71313705
19MP0003938_abnormal_ear_development1.62616519
20MP0004957_abnormal_blastocyst_morpholog1.58550587
21MP0003186_abnormal_redox_activity1.57051791
22MP0000049_abnormal_middle_ear1.51745443
23MP0008995_early_reproductive_senescence1.47021967
24MP0004145_abnormal_muscle_electrophysio1.46433740
25MP0000631_abnormal_neuroendocrine_gland1.44466183
26MP0002736_abnormal_nociception_after1.42129980
27MP0005551_abnormal_eye_electrophysiolog1.41209297
28MP0003718_maternal_effect1.40348766
29MP0006072_abnormal_retinal_apoptosis1.39554574
30MP0003941_abnormal_skin_development1.38648335
31MP0002822_catalepsy1.36985097
32MP0003937_abnormal_limbs/digits/tail_de1.32879818
33MP0003880_abnormal_central_pattern1.32787778
34MP0008877_abnormal_DNA_methylation1.32062717
35MP0003890_abnormal_embryonic-extraembry1.31859961
36MP0001485_abnormal_pinna_reflex1.30079685
37MP0004885_abnormal_endolymph1.27213638
38MP0004133_heterotaxia1.27047929
39MP0003693_abnormal_embryo_hatching1.22197543
40MP0002837_dystrophic_cardiac_calcinosis1.20230418
41MP0009745_abnormal_behavioral_response1.19121761
42MP0008789_abnormal_olfactory_epithelium1.17631605
43MP0002735_abnormal_chemical_nociception1.15398592
44MP0008875_abnormal_xenobiotic_pharmacok1.14977580
45MP0001286_abnormal_eye_development1.12403717
46MP0006035_abnormal_mitochondrial_morpho1.09474396
47MP0005253_abnormal_eye_physiology1.07777876
48MP0001968_abnormal_touch/_nociception1.06232257
49MP0006276_abnormal_autonomic_nervous1.05797981
50MP0006036_abnormal_mitochondrial_physio1.05266008
51MP0003567_abnormal_fetal_cardiomyocyte1.04285060
52MP0005379_endocrine/exocrine_gland_phen1.04184981
53MP0003806_abnormal_nucleotide_metabolis1.02738835
54MP0003315_abnormal_perineum_morphology1.02366459
55MP0009250_abnormal_appendicular_skeleto1.02255445
56MP0002160_abnormal_reproductive_system1.02249230
57MP0002234_abnormal_pharynx_morphology1.02011606
58MP0004742_abnormal_vestibular_system1.00582199
59MP0005187_abnormal_penis_morphology0.99651503
60MP0002210_abnormal_sex_determination0.99442753
61MP0002653_abnormal_ependyma_morphology0.96159987
62MP0000778_abnormal_nervous_system0.95927805
63MP0005410_abnormal_fertilization0.94000858
64MP0002697_abnormal_eye_size0.93371038
65MP0001984_abnormal_olfaction0.91452559
66MP0005391_vision/eye_phenotype0.89221724
67MP0000026_abnormal_inner_ear0.87535210
68MP0003787_abnormal_imprinting0.87374029
69MP0003878_abnormal_ear_physiology0.87334370
70MP0005377_hearing/vestibular/ear_phenot0.87334370
71MP0003283_abnormal_digestive_organ0.86040202
72MP0008872_abnormal_physiological_respon0.85984217
73MP0003122_maternal_imprinting0.85895974
74MP0002557_abnormal_social/conspecific_i0.85669365
75MP0002928_abnormal_bile_duct0.85602357
76MP0003786_premature_aging0.85226684
77MP0005389_reproductive_system_phenotype0.85206292
78MP0005195_abnormal_posterior_eye0.85127688
79MP0000653_abnormal_sex_gland0.84887927
80MP0001905_abnormal_dopamine_level0.84313356
81MP0002876_abnormal_thyroid_physiology0.84167072
82MP0002184_abnormal_innervation0.83886753
83MP0002752_abnormal_somatic_nervous0.82793404
84MP0002282_abnormal_trachea_morphology0.82465759
85MP0002233_abnormal_nose_morphology0.81007816
86MP0003936_abnormal_reproductive_system0.80322241
87MP0002734_abnormal_mechanical_nocicepti0.80092732
88MP0002095_abnormal_skin_pigmentation0.79796682
89MP0001881_abnormal_mammary_gland0.79327668
90MP0003119_abnormal_digestive_system0.78841538
91MP0005394_taste/olfaction_phenotype0.77892388
92MP0005499_abnormal_olfactory_system0.77892388
93MP0003121_genomic_imprinting0.77782269
94MP0001486_abnormal_startle_reflex0.77533686
95MP0004147_increased_porphyrin_level0.77383141
96MP0001970_abnormal_pain_threshold0.77056328
97MP0001145_abnormal_male_reproductive0.76707800
98MP0002272_abnormal_nervous_system0.76108341
99MP0003195_calcinosis0.73580993
100MP0003942_abnormal_urinary_system0.73173639

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.34833537
2Acute necrotizing encephalopathy (HP:0006965)5.18404221
3Abnormality of cells of the erythroid lineage (HP:0012130)4.77518789
4Macrocytic anemia (HP:0001972)4.54747801
5Abnormal number of erythroid precursors (HP:0012131)4.52574411
6Increased hepatocellular lipid droplets (HP:0006565)4.47867168
7Abnormal mitochondria in muscle tissue (HP:0008316)4.39459578
8Mitochondrial inheritance (HP:0001427)4.37532091
9Acute encephalopathy (HP:0006846)4.35047529
10Progressive macrocephaly (HP:0004481)4.28421836
11Lipid accumulation in hepatocytes (HP:0006561)4.03197065
12Increased CSF lactate (HP:0002490)3.87179394
13Renal Fanconi syndrome (HP:0001994)3.60196949
14Septo-optic dysplasia (HP:0100842)3.46488859
15Cerebral edema (HP:0002181)3.43829785
16Congenital, generalized hypertrichosis (HP:0004540)3.34406582
17Hepatocellular necrosis (HP:0001404)3.29291703
18Pallor (HP:0000980)3.23627990
19Colon cancer (HP:0003003)3.17182968
20Aplastic anemia (HP:0001915)3.14778062
21Hepatic necrosis (HP:0002605)2.99104516
22Concave nail (HP:0001598)2.93538544
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89512701
243-Methylglutaconic aciduria (HP:0003535)2.87798467
25Exertional dyspnea (HP:0002875)2.82910099
26Pancreatic fibrosis (HP:0100732)2.71251736
27Stenosis of the external auditory canal (HP:0000402)2.70091257
28Increased intramyocellular lipid droplets (HP:0012240)2.64165785
29Optic disc pallor (HP:0000543)2.63991570
30Abnormality of renal resorption (HP:0011038)2.51862939
31Pancreatic cysts (HP:0001737)2.47222512
32Oral leukoplakia (HP:0002745)2.47146355
33Partial duplication of thumb phalanx (HP:0009944)2.46950711
34Leukodystrophy (HP:0002415)2.42888275
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41505715
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41505715
37Abnormality of midbrain morphology (HP:0002418)2.40874754
38Molar tooth sign on MRI (HP:0002419)2.40874754
39Methylmalonic acidemia (HP:0002912)2.40728395
40True hermaphroditism (HP:0010459)2.37960929
41Pendular nystagmus (HP:0012043)2.36878551
42Absent septum pellucidum (HP:0001331)2.36008226
43Abnormality of the labia minora (HP:0012880)2.34687706
44Supernumerary spleens (HP:0009799)2.32040043
45Respiratory difficulties (HP:0002880)2.31942963
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31346359
47Congenital stationary night blindness (HP:0007642)2.31069993
48Glycosuria (HP:0003076)2.29711997
49Abnormality of urine glucose concentration (HP:0011016)2.29711997
50Abnormal respiratory epithelium morphology (HP:0012253)2.28645298
51Abnormal respiratory motile cilium morphology (HP:0005938)2.28645298
52Abnormal ciliary motility (HP:0012262)2.26442236
53Respiratory failure (HP:0002878)2.22666157
54Medial flaring of the eyebrow (HP:0010747)2.22400055
55Absent/shortened dynein arms (HP:0200106)2.22041817
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.22041817
57Increased serum lactate (HP:0002151)2.21763340
58Nephronophthisis (HP:0000090)2.20423808
59Exercise intolerance (HP:0003546)2.20056352
60Partial duplication of the phalanx of hand (HP:0009999)2.18672707
61Lactic acidosis (HP:0003128)2.17733161
62Abnormal respiratory motile cilium physiology (HP:0012261)2.10952062
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10417127
64Lethargy (HP:0001254)2.07580006
65Increased muscle lipid content (HP:0009058)2.07202955
66Abnormal number of incisors (HP:0011064)2.06955012
67Depressed nasal ridge (HP:0000457)2.03863929
68Hyperglycinemia (HP:0002154)2.02722991
69Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02081787
70Maternal diabetes (HP:0009800)2.01890053
71Methylmalonic aciduria (HP:0012120)2.00297127
72Hyperphosphaturia (HP:0003109)1.98615915
73Triphalangeal thumb (HP:0001199)1.97655948
74Myokymia (HP:0002411)1.96014100
75Abnormality of the septum pellucidum (HP:0007375)1.93620579
76Rhinitis (HP:0012384)1.91616878
77Anencephaly (HP:0002323)1.87174909
78Abnormal rod and cone electroretinograms (HP:0008323)1.85025645
79Anophthalmia (HP:0000528)1.83237509
80Abnormality of the renal medulla (HP:0100957)1.82515155
81Absent thumb (HP:0009777)1.82186803
82Optic nerve hypoplasia (HP:0000609)1.81045431
83Esophageal atresia (HP:0002032)1.81031689
84Abnormality of the middle phalanges of the toes (HP:0010183)1.80402554
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80280963
86Cerebral hypomyelination (HP:0006808)1.79149220
87Bilateral microphthalmos (HP:0007633)1.77717086
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.76286758
89Degeneration of anterior horn cells (HP:0002398)1.75215664
90Abnormality of the anterior horn cell (HP:0006802)1.75215664
91Hypoplasia of the radius (HP:0002984)1.75057548
92Asplenia (HP:0001746)1.74222702
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73461234
94Sclerocornea (HP:0000647)1.70541904
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.70487031
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70487031
97Abnormality of the pons (HP:0007361)1.69444504
98Pancytopenia (HP:0001876)1.67914265
99Hypoplasia of the pons (HP:0012110)1.65910502
100Cleft eyelid (HP:0000625)1.63764428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.65856556
2STK162.59451998
3TAF12.56189737
4ZAK2.55245460
5RIPK12.43345396
6BMPR1B2.37728780
7VRK12.36177969
8PASK2.35616469
9CDC72.27585479
10TNIK2.22993655
11MAP4K22.15489237
12BUB12.14074341
13NEK12.13676111
14DYRK22.13501625
15STK242.03189791
16NME11.94364552
17WNK31.89811928
18GRK11.88685977
19PNCK1.85625212
20ADRBK21.76990292
21DYRK31.75400180
22NUAK11.70347675
23PRKCI1.69549673
24PBK1.67047698
25WNK41.65645157
26PLK31.60344770
27PRKCG1.50155811
28EIF2AK31.47058764
29TLK11.40341124
30PINK11.33203736
31PDK21.32481144
32PLK41.32427824
33EPHB21.31120590
34SRPK11.30806977
35WEE11.29660187
36TTK1.27916324
37FRK1.22855712
38MAP3K121.11485332
39FGFR21.10631224
40BCKDK1.06202313
41TIE11.03461149
42MST41.02261038
43TXK1.00314697
44NME20.99588634
45BRSK20.98094364
46NLK0.97324017
47TSSK60.95815182
48CDK190.94921858
49TGFBR10.90941196
50PLK10.90573401
51DAPK30.90560097
52TAOK30.90378468
53INSRR0.89950568
54ACVR1B0.84567172
55MKNK10.82240736
56PRKCE0.78325625
57MKNK20.77444001
58STK38L0.76308809
59TRIM280.76107682
60CDK80.75246367
61CSNK2A20.73656658
62EPHA40.73419094
63AURKB0.72876110
64LRRK20.72720326
65CHEK20.72320159
66STK40.72301676
67BRSK10.68649959
68FGFR10.67218615
69CSNK2A10.64621580
70ADRBK10.63205356
71ILK0.62978909
72CASK0.60047119
73MAP3K40.59844917
74PAK30.56398563
75MAP2K70.53041597
76OBSCN0.52856927
77FLT30.52796673
78CAMK10.52668541
79MAP4K10.51789018
80PRKCQ0.50133486
81MAPK150.46110661
82ATR0.44742864
83PRKCD0.43032236
84PRKACA0.42946022
85STK390.41406760
86MARK10.41103401
87OXSR10.40604650
88STK30.38413030
89CSNK1E0.37596842
90AURKA0.36279715
91MAP3K90.35650072
92RPS6KA50.34533428
93DYRK1A0.33792384
94TEC0.33432083
95WNK10.33203802
96CSNK1A10.31690376
97CSNK1G10.31050809
98PLK20.30816873
99ATM0.29693402
100PRKG10.28076585

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.82129041
2Oxidative phosphorylation_Homo sapiens_hsa001904.94161259
3Parkinsons disease_Homo sapiens_hsa050124.30587181
4Proteasome_Homo sapiens_hsa030503.16895529
5Huntingtons disease_Homo sapiens_hsa050163.13894096
6Alzheimers disease_Homo sapiens_hsa050102.86815801
7Protein export_Homo sapiens_hsa030602.74284708
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.66057558
9Cardiac muscle contraction_Homo sapiens_hsa042602.52919813
10RNA polymerase_Homo sapiens_hsa030202.28036862
11Homologous recombination_Homo sapiens_hsa034401.96670589
12Mismatch repair_Homo sapiens_hsa034301.80951083
13RNA degradation_Homo sapiens_hsa030181.80338848
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76294700
15Basal transcription factors_Homo sapiens_hsa030221.61651109
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60858401
17DNA replication_Homo sapiens_hsa030301.59586597
18Spliceosome_Homo sapiens_hsa030401.49080529
19Nitrogen metabolism_Homo sapiens_hsa009101.41665180
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41388539
21One carbon pool by folate_Homo sapiens_hsa006701.35780222
22RNA transport_Homo sapiens_hsa030131.23351597
23Fanconi anemia pathway_Homo sapiens_hsa034601.15877015
24Pyrimidine metabolism_Homo sapiens_hsa002401.11844058
25Tyrosine metabolism_Homo sapiens_hsa003501.09813584
26Nucleotide excision repair_Homo sapiens_hsa034201.05661007
27Base excision repair_Homo sapiens_hsa034101.05634184
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04147167
29Phototransduction_Homo sapiens_hsa047441.03249576
30Linoleic acid metabolism_Homo sapiens_hsa005911.02642957
31Nicotine addiction_Homo sapiens_hsa050331.00556259
32Propanoate metabolism_Homo sapiens_hsa006400.96587759
33Sulfur relay system_Homo sapiens_hsa041220.94885049
34Purine metabolism_Homo sapiens_hsa002300.94466463
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90118967
36Basal cell carcinoma_Homo sapiens_hsa052170.89149305
37Pyruvate metabolism_Homo sapiens_hsa006200.86390872
38Tryptophan metabolism_Homo sapiens_hsa003800.86279281
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85112000
40Caffeine metabolism_Homo sapiens_hsa002320.82398008
41Butanoate metabolism_Homo sapiens_hsa006500.82201195
42Folate biosynthesis_Homo sapiens_hsa007900.81558743
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79160989
44TGF-beta signaling pathway_Homo sapiens_hsa043500.74717218
45Mineral absorption_Homo sapiens_hsa049780.73712530
46Olfactory transduction_Homo sapiens_hsa047400.73471521
47Metabolic pathways_Homo sapiens_hsa011000.73073790
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72996830
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.72762350
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72254864
51Peroxisome_Homo sapiens_hsa041460.71036370
52Glutathione metabolism_Homo sapiens_hsa004800.70187239
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69953685
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68767104
55Regulation of autophagy_Homo sapiens_hsa041400.67434675
56Steroid biosynthesis_Homo sapiens_hsa001000.66215025
57Hedgehog signaling pathway_Homo sapiens_hsa043400.65710789
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.65534850
59Chemical carcinogenesis_Homo sapiens_hsa052040.63659254
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61419172
61Fat digestion and absorption_Homo sapiens_hsa049750.59792448
62Vitamin digestion and absorption_Homo sapiens_hsa049770.59542528
63Selenocompound metabolism_Homo sapiens_hsa004500.59073776
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58464193
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57070365
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56913563
67Retinol metabolism_Homo sapiens_hsa008300.55758942
68Taste transduction_Homo sapiens_hsa047420.55592463
69Non-homologous end-joining_Homo sapiens_hsa034500.49184248
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46774955
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.45144637
72Collecting duct acid secretion_Homo sapiens_hsa049660.43986502
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42975259
74beta-Alanine metabolism_Homo sapiens_hsa004100.41907003
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41780173
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38891920
77Glycerolipid metabolism_Homo sapiens_hsa005610.37621830
78Morphine addiction_Homo sapiens_hsa050320.36658988
79Fatty acid degradation_Homo sapiens_hsa000710.35942806
80Serotonergic synapse_Homo sapiens_hsa047260.34560577
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32597335
82Arachidonic acid metabolism_Homo sapiens_hsa005900.31794620
83Cell cycle_Homo sapiens_hsa041100.30310823
84Ether lipid metabolism_Homo sapiens_hsa005650.29293261
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28627749
86Fatty acid elongation_Homo sapiens_hsa000620.25712015
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24233915
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23357421
89Sulfur metabolism_Homo sapiens_hsa009200.22950107
90Fatty acid metabolism_Homo sapiens_hsa012120.22069897
91Vitamin B6 metabolism_Homo sapiens_hsa007500.21877011
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.21131800
93Ovarian steroidogenesis_Homo sapiens_hsa049130.18921272
94Hippo signaling pathway_Homo sapiens_hsa043900.17284594
95Wnt signaling pathway_Homo sapiens_hsa043100.16453213
96p53 signaling pathway_Homo sapiens_hsa041150.16115163
97Arginine and proline metabolism_Homo sapiens_hsa003300.15478691
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14778299
99GABAergic synapse_Homo sapiens_hsa047270.14752549
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14175429

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