RPSAP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of muscle hypertrophy (GO:0014741)9.69781205
2skeletal muscle tissue regeneration (GO:0043403)9.05616711
3locomotory exploration behavior (GO:0035641)8.78707954
4actin-myosin filament sliding (GO:0033275)8.68402175
5muscle filament sliding (GO:0030049)8.68402175
6regulation of transmission of nerve impulse (GO:0051969)8.50441861
7negative regulation of skeletal muscle tissue development (GO:0048642)8.09546655
8regulation of skeletal muscle contraction (GO:0014819)7.77239265
9response to muscle activity (GO:0014850)7.53553444
10actin-mediated cell contraction (GO:0070252)7.08552351
11neuron cell-cell adhesion (GO:0007158)7.07173385
12neurotransmitter-gated ion channel clustering (GO:0072578)6.13340409
13cellular response to dexamethasone stimulus (GO:0071549)6.02106132
14positive regulation of synaptic transmission, glutamatergic (GO:0051968)5.85038262
15striated muscle adaptation (GO:0014888)5.67281963
16response to dexamethasone (GO:0071548)5.57129621
17response to activity (GO:0014823)5.49140934
18positive regulation of neurological system process (GO:0031646)5.48367958
19response to inactivity (GO:0014854)5.26437350
20actin filament-based movement (GO:0030048)5.16681734
21auditory behavior (GO:0031223)5.05571131
22exploration behavior (GO:0035640)4.98099448
23regulation of muscle hypertrophy (GO:0014743)4.97292728
24postsynaptic membrane organization (GO:0001941)4.93610392
25regulation of synapse maturation (GO:0090128)4.59899838
26regulation of DNA methylation (GO:0044030)4.59260868
27mechanosensory behavior (GO:0007638)4.57616622
28muscle adaptation (GO:0043500)4.56126513
29response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.46964923
30presynaptic membrane assembly (GO:0097105)4.39578920
31motor neuron axon guidance (GO:0008045)4.13212756
32regulation of relaxation of muscle (GO:1901077)4.07768286
33myotube cell development (GO:0014904)4.07020274
34muscle organ development (GO:0007517)4.03605582
35negative regulation of fibroblast apoptotic process (GO:2000270)4.03129914
36muscle structure development (GO:0061061)4.02624054
37protein K6-linked ubiquitination (GO:0085020)4.01236771
38negative regulation of axon extension (GO:0030517)3.95803836
39skeletal muscle contraction (GO:0003009)3.93224082
40response to electrical stimulus (GO:0051602)3.80332790
41dosage compensation (GO:0007549)3.78827938
42negative regulation of developmental growth (GO:0048640)3.75652651
43negative regulation of fatty acid biosynthetic process (GO:0045717)3.66387073
44protein trimerization (GO:0070206)3.65109794
45presynaptic membrane organization (GO:0097090)3.57230764
46dendritic spine morphogenesis (GO:0060997)3.53411073
47inositol metabolic process (GO:0006020)3.50746697
48skeletal muscle fiber development (GO:0048741)3.48996022
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48479408
50negative regulation of translation, ncRNA-mediated (GO:0040033)3.48479408
51regulation of translation, ncRNA-mediated (GO:0045974)3.48479408
52tissue regeneration (GO:0042246)3.41442418
53lysine catabolic process (GO:0006554)3.40105180
54lysine metabolic process (GO:0006553)3.40105180
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.31766256
56response to testosterone (GO:0033574)3.30992509
57forebrain cell migration (GO:0021885)3.26457135
58regulation of centriole replication (GO:0046599)3.21826909
59telencephalon cell migration (GO:0022029)3.17875824
60positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.16650756
61protein localization to synapse (GO:0035418)3.16129367
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12391995
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.09251102
64muscle system process (GO:0003012)3.07909194
65negative regulation of organelle assembly (GO:1902116)3.06919752
66cerebral cortex radially oriented cell migration (GO:0021799)3.02090022
67positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.00897811
68heparin biosynthetic process (GO:0030210)3.00033845
69heparin metabolic process (GO:0030202)3.00033845
70cranial nerve structural organization (GO:0021604)3.00018788
71muscle contraction (GO:0006936)2.96424949
72sarcoplasmic reticulum calcium ion transport (GO:0070296)2.94832081
73negative regulation of striated muscle tissue development (GO:0045843)2.94799407
74vocalization behavior (GO:0071625)2.94288210
75placenta development (GO:0001890)2.91698441
76response to auditory stimulus (GO:0010996)2.91011806
77positive regulation of synapse maturation (GO:0090129)2.87499592
78negative regulation of muscle tissue development (GO:1901862)2.86714251
79cellular response to glucocorticoid stimulus (GO:0071385)2.83602663
80regulation of synaptic transmission, glutamatergic (GO:0051966)2.83416432
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82627377
82righting reflex (GO:0060013)2.80477437
83mitochondrial calcium ion homeostasis (GO:0051560)2.79360759
84cellular response to ketone (GO:1901655)2.78802865
85I-kappaB phosphorylation (GO:0007252)2.78315670
86negative regulation of muscle organ development (GO:0048635)2.76759532
87positive regulation of histone H3-K4 methylation (GO:0051571)2.72695622
88protein polyglutamylation (GO:0018095)2.72458082
89cellular response to corticosteroid stimulus (GO:0071384)2.66681282
90regulation of histone H3-K9 methylation (GO:0051570)2.62868908
91protein neddylation (GO:0045116)2.62742574
92negative regulation of fatty acid metabolic process (GO:0045922)2.62600585
93striated muscle contraction (GO:0006941)2.61511045
94negative regulation of histone acetylation (GO:0035067)2.58243453
95response to gravity (GO:0009629)13.0156914
96skeletal muscle adaptation (GO:0043501)11.8692438
97striated muscle atrophy (GO:0014891)11.4983146
98regulation of neuron projection regeneration (GO:0070570)10.6113996
99regulation of axon regeneration (GO:0048679)10.6113996
100muscle atrophy (GO:0014889)10.2987636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human6.34857149
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.43917838
3TAF15_26573619_Chip-Seq_HEK293_Human4.42194838
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.75971513
5AR_21572438_ChIP-Seq_LNCaP_Human3.68429395
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.40784394
7EZH2_22144423_ChIP-Seq_EOC_Human3.36350972
8FUS_26573619_Chip-Seq_HEK293_Human3.29089386
9ZFP57_27257070_Chip-Seq_ESCs_Mouse3.22795465
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21116970
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.89159961
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84423359
13GBX2_23144817_ChIP-Seq_PC3_Human2.58243512
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52823678
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.44469551
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.23233406
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.17275613
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12521156
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07883589
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97624066
21SMAD4_21799915_ChIP-Seq_A2780_Human1.94540998
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86787028
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85098544
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.84285490
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83658402
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.83276979
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.78699060
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77249339
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76258029
30ER_23166858_ChIP-Seq_MCF-7_Human1.72018828
31RXR_22108803_ChIP-Seq_LS180_Human1.61683273
32ZNF274_21170338_ChIP-Seq_K562_Hela1.60684260
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59166362
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56332028
35TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55826741
36KDM2B_26808549_Chip-Seq_REH_Human1.54660943
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54273986
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53411572
39TCF4_23295773_ChIP-Seq_U87_Human1.49478454
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48825349
41P300_19829295_ChIP-Seq_ESCs_Human1.48517139
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46698083
43REST_21632747_ChIP-Seq_MESCs_Mouse1.46214841
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41660645
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.41492490
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41089434
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39870427
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.39076309
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38333249
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37425585
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37274432
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37120840
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.37020131
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36229113
55SOX9_26525672_Chip-Seq_HEART_Mouse1.32087887
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31503299
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30252263
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29065966
59STAT3_23295773_ChIP-Seq_U87_Human1.28300164
60EWS_26573619_Chip-Seq_HEK293_Human1.26122948
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25034048
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25034048
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24353035
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23774648
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.18838504
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18076227
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18076227
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16956684
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.15891767
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14353915
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14032983
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14032983
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.12909625
74RNF2_27304074_Chip-Seq_NSC_Mouse1.11168914
75CBP_20019798_ChIP-Seq_JUKART_Human1.09503516
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09503516
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.07846998
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.07489814
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.06087516
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05760114
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04024402
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03894333
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03398388
84AHR_22903824_ChIP-Seq_MCF-7_Human1.02291208
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02014077
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01105791
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00817747
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00092368
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.00041712
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99160245
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98886884
92GATA1_22025678_ChIP-Seq_K562_Human0.97281625
93TP53_22573176_ChIP-Seq_HFKS_Human0.97215600
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97208670
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96934986
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96675124
97TP53_18474530_ChIP-ChIP_U2OS_Human0.95927016
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93798325
99BCAT_22108803_ChIP-Seq_LS180_Human0.93631085
100P53_22387025_ChIP-Seq_ESCs_Mouse0.93320463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after5.64154448
2MP0000747_muscle_weakness5.06783357
3MP0004782_abnormal_surfactant_physiolog5.01048267
4MP0004145_abnormal_muscle_electrophysio4.98260092
5MP0001968_abnormal_touch/_nociception3.97120618
6MP0000749_muscle_degeneration3.88232599
7MP0002089_abnormal_postnatal_growth/wei3.82348697
8MP0004036_abnormal_muscle_relaxation3.41050799
9MP0003705_abnormal_hypodermis_morpholog3.22870205
10MP0004270_analgesia3.12705902
11MP0000759_abnormal_skeletal_muscle2.99353847
12MP0002269_muscular_atrophy2.96941710
13MP0000751_myopathy2.87318499
14MP0002108_abnormal_muscle_morphology2.49490733
15MP0003959_abnormal_lean_body2.44345716
16MP0004087_abnormal_muscle_fiber2.35802222
17MP0002106_abnormal_muscle_physiology2.32653112
18MP0002735_abnormal_chemical_nociception2.27986598
19MP0005620_abnormal_muscle_contractility2.23169848
20MP0000631_abnormal_neuroendocrine_gland2.18195483
21MP0005369_muscle_phenotype1.95109479
22MP0000569_abnormal_digit_pigmentation1.92590972
23MP0004885_abnormal_endolymph1.90050129
24MP0004859_abnormal_synaptic_plasticity1.89968870
25MP0003880_abnormal_central_pattern1.85176379
26MP0000733_abnormal_muscle_development1.63140386
27MP0002638_abnormal_pupillary_reflex1.46052991
28MP0005083_abnormal_biliary_tract1.45455966
29MP0002272_abnormal_nervous_system1.41628585
30MP0005423_abnormal_somatic_nervous1.36480407
31MP0001986_abnormal_taste_sensitivity1.34570799
32MP0000372_irregular_coat_pigmentation1.28541081
33MP0000427_abnormal_hair_cycle1.25597195
34MP0001486_abnormal_startle_reflex1.25106320
35MP0003115_abnormal_respiratory_system1.22185086
36MP0000566_synostosis1.21700759
37MP0000750_abnormal_muscle_regeneration1.21553737
38MP0001879_abnormal_lymphatic_vessel1.19983379
39MP0001485_abnormal_pinna_reflex1.19501490
40MP0002734_abnormal_mechanical_nocicepti1.19256732
41MP0010307_abnormal_tumor_latency1.19039191
42MP0002067_abnormal_sensory_capabilities1.17440623
43MP0004484_altered_response_of1.08396778
44MP0003045_fibrosis1.06493207
45MP0005187_abnormal_penis_morphology1.05156935
46MP0002896_abnormal_bone_mineralization1.04941232
47MP0003632_abnormal_nervous_system1.02161857
48MP0008057_abnormal_DNA_replication1.01336413
49MP0003646_muscle_fatigue1.00889430
50MP0004215_abnormal_myocardial_fiber1.00758081
51MP0005408_hypopigmentation0.94000677
52MP0002733_abnormal_thermal_nociception0.92865269
53MP0004142_abnormal_muscle_tone0.92493154
54MP0005171_absent_coat_pigmentation0.91243482
55MP0004084_abnormal_cardiac_muscle0.89924351
56MP0001970_abnormal_pain_threshold0.88507311
57MP0000467_abnormal_esophagus_morphology0.88284834
58MP0002095_abnormal_skin_pigmentation0.85580904
59MP0009250_abnormal_appendicular_skeleto0.81246335
60MP0003937_abnormal_limbs/digits/tail_de0.79462144
61MP0009780_abnormal_chondrocyte_physiolo0.79146065
62MP0005386_behavior/neurological_phenoty0.78216576
63MP0004924_abnormal_behavior0.78216576
64MP0002115_abnormal_skeleton_extremities0.77405152
65MP0002332_abnormal_exercise_endurance0.76180246
66MP0002184_abnormal_innervation0.75964430
67MP0003786_premature_aging0.74414014
68MP0003950_abnormal_plasma_membrane0.73943288
69MP0000778_abnormal_nervous_system0.73691011
70MP0003635_abnormal_synaptic_transmissio0.71268651
71MP0001440_abnormal_grooming_behavior0.70817332
72MP0009745_abnormal_behavioral_response0.70123169
73MP0004133_heterotaxia0.69401051
74MP0002109_abnormal_limb_morphology0.67820638
75MP0002557_abnormal_social/conspecific_i0.67718726
76MP0002114_abnormal_axial_skeleton0.63696275
77MP0001943_abnormal_respiration0.62031408
78MP0003385_abnormal_body_wall0.58065309
79MP0002063_abnormal_learning/memory/cond0.57824857
80MP0003631_nervous_system_phenotype0.57297785
81MP0000920_abnormal_myelination0.56958171
82MP0000647_abnormal_sebaceous_gland0.56293457
83MP0003755_abnormal_palate_morphology0.54324402
84MP0002152_abnormal_brain_morphology0.54178321
85MP0004134_abnormal_chest_morphology0.53807925
86MP0000049_abnormal_middle_ear0.53369769
87MP0002064_seizures0.53103003
88MP0008438_abnormal_cutaneous_collagen0.53045426
89MP0009046_muscle_twitch0.52218425
90MP0002066_abnormal_motor_capabilities/c0.52100345
91MP0000955_abnormal_spinal_cord0.52014689
92MP0005551_abnormal_eye_electrophysiolog0.51043805
93MP0004742_abnormal_vestibular_system0.50533142
94MP0004130_abnormal_muscle_cell0.49490624
95MP0005248_abnormal_Harderian_gland0.47259515
96MP0001765_abnormal_ion_homeostasis0.46484022
97MP0004147_increased_porphyrin_level0.45603129
98MP0003948_abnormal_gas_homeostasis0.44870620
99MP0003806_abnormal_nucleotide_metabolis0.44401263
100MP0002138_abnormal_hepatobiliary_system0.44302047

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)8.33931888
2Distal arthrogryposis (HP:0005684)6.47607225
3Exercise-induced myalgia (HP:0003738)6.39004123
4Round ear (HP:0100830)6.19339349
5Mask-like facies (HP:0000298)6.08794219
6Nemaline bodies (HP:0003798)5.69925494
7Abnormality of the sella turcica (HP:0002679)5.36598356
8Abnormality of the septum pellucidum (HP:0007375)5.31140119
9Absent phalangeal crease (HP:0006109)5.23509879
10Optic nerve hypoplasia (HP:0000609)5.21380359
11Ulnar deviation of the wrist (HP:0003049)5.09611032
12Absent septum pellucidum (HP:0001331)4.80915065
13Abnormal finger flexion creases (HP:0006143)4.64080104
14Muscle fiber inclusion bodies (HP:0100299)4.61748326
15Calcaneovalgus deformity (HP:0001848)4.60436782
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.51996318
17Hyperkalemia (HP:0002153)4.48547775
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)4.44960644
19Deformed tarsal bones (HP:0008119)4.24924001
20Type 1 muscle fiber predominance (HP:0003803)3.98320787
21Periorbital edema (HP:0100539)3.53646452
22Facial edema (HP:0000282)3.39946577
23Exercise-induced muscle cramps (HP:0003710)3.32463651
24Growth hormone deficiency (HP:0000824)3.32112002
25Myopathic facies (HP:0002058)3.31322492
26Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.09341938
27Broad-based gait (HP:0002136)3.08930641
28Stomach cancer (HP:0012126)3.04708208
29Focal motor seizures (HP:0011153)2.80592699
30Conjunctival hamartoma (HP:0100780)2.79315157
31Hyperventilation (HP:0002883)2.75857838
32Metatarsus adductus (HP:0001840)2.71073737
33Asplenia (HP:0001746)2.65043384
34Overgrowth (HP:0001548)2.61252752
35Myoglobinuria (HP:0002913)2.57835111
36Abnormality of potassium homeostasis (HP:0011042)2.55781610
37Neoplasm of the heart (HP:0100544)2.45222257
38Increased connective tissue (HP:0009025)2.45059043
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.44229443
40Abnormal biliary tract physiology (HP:0012439)2.42347363
41Bile duct proliferation (HP:0001408)2.42347363
42Subacute progressive viral hepatitis (HP:0006572)2.40331516
43Decreased circulating renin level (HP:0003351)2.39871411
44Primary amenorrhea (HP:0000786)2.33183011
45Epileptic encephalopathy (HP:0200134)2.33177238
46Myotonia (HP:0002486)2.30963923
47Megalencephaly (HP:0001355)2.28860712
48Abnormality of the calcaneus (HP:0008364)2.25355920
49Pancreatic fibrosis (HP:0100732)2.24479207
50Large earlobe (HP:0009748)2.21146055
51Difficulty running (HP:0009046)2.18951309
52True hermaphroditism (HP:0010459)2.16180390
53Protruding tongue (HP:0010808)2.10920815
54Furrowed tongue (HP:0000221)2.08994158
55Occipital encephalocele (HP:0002085)2.06346703
56Nonprogressive disorder (HP:0003680)2.04133018
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.00319947
58Septo-optic dysplasia (HP:0100842)10.0672551
59Supernumerary spleens (HP:0009799)1.99386989
60Alveolar cell carcinoma (HP:0006519)1.96527843
61Hamartoma of the eye (HP:0010568)1.92692073
62Pancreatic cysts (HP:0001737)1.87119379
63Congenital sensorineural hearing impairment (HP:0008527)1.85486037
64Abnormal umbilical cord blood vessels (HP:0011403)1.81500133
65Single umbilical artery (HP:0001195)1.81500133
66Abnormality of the fetal cardiovascular system (HP:0010948)1.81500133
67Down-sloping shoulders (HP:0200021)1.80555680
68Atrioventricular block (HP:0001678)1.80033362
69Muscle hypertrophy of the lower extremities (HP:0008968)1.78580566
70Neoplasm of the tracheobronchial system (HP:0100552)1.75202451
71Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.72623658
72Primary adrenal insufficiency (HP:0008207)1.71128564
73Wrist flexion contracture (HP:0001239)1.70514070
74Malignant hyperthermia (HP:0002047)1.69362007
75Hypoplastic ischia (HP:0003175)1.63520876
76Hypokalemia (HP:0002900)1.60255847
77Rhabdomyolysis (HP:0003201)1.60137418
78Chorioretinal atrophy (HP:0000533)1.60044825
79Fibular aplasia (HP:0002990)1.59924503
802-3 toe syndactyly (HP:0004691)1.58281368
81Natal tooth (HP:0000695)1.58045867
82Breech presentation (HP:0001623)1.57168476
83Cerebellar dysplasia (HP:0007033)1.56621315
84Heart block (HP:0012722)1.56608654
85Absent speech (HP:0001344)1.56107806
86Increased variability in muscle fiber diameter (HP:0003557)1.52802084
87Bone cyst (HP:0012062)1.52696072
88Smooth philtrum (HP:0000319)1.52417276
89Hyperuricemia (HP:0002149)1.52198357
90Increased purine levels (HP:0004368)1.52198357
91Hamartoma (HP:0010566)1.50924470
92Germ cell neoplasia (HP:0100728)1.50674421
93Intellectual disability, moderate (HP:0002342)1.50614369
94Bell-shaped thorax (HP:0001591)1.49968141
95Microglossia (HP:0000171)1.49016437
96Nephroblastoma (Wilms tumor) (HP:0002667)1.48702239
97Oligomenorrhea (HP:0000876)1.48154065
98Neonatal hypoglycemia (HP:0001998)1.47042074
99Abnormality of chloride homeostasis (HP:0011422)1.46049612
100Embryonal renal neoplasm (HP:0011794)1.44152789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.77586863
2PBK3.57387522
3ERBB43.47130373
4PHKG23.46367557
5PHKG13.46367557
6OBSCN3.27064446
7TIE12.98694897
8MARK12.62298613
9WNK42.61079221
10CAMK1D2.54560475
11CAMK1G2.33576168
12TYRO31.98543558
13WNK11.95501193
14MAPK131.67958724
15MKNK21.66874473
16TNIK1.59282807
17STK391.50858377
18AKT31.50213756
19NUAK11.41622418
20PIK3CG1.34315154
21FRK1.33224998
22DMPK1.25767691
23CAMKK21.17903447
24PIK3CA1.14208512
25PINK11.13936963
26CAMK2G1.07645957
27STK161.01410193
28IRAK11.01118334
29PDK21.00414142
30JAK30.98468427
31CHEK20.90251318
32SGK20.88073880
33MAPK70.84803968
34DYRK20.84338358
35NME10.72594123
36DYRK1B0.71035390
37CSNK1A1L0.70624991
38MAP4K20.70602978
39CDK40.69349690
40NTRK30.68883791
41AKT20.65052007
42CSNK1G10.65013502
43MKNK10.64468026
44SGK10.62018390
45CAMK40.60801499
46LATS10.60291139
47PLK20.59768980
48SGK2230.58180522
49SGK4940.58180522
50MUSK0.57431370
51CCNB10.55821960
52CAMK10.55201198
53FER0.53018966
54MAP3K70.52405156
55CSNK1G20.51032379
56TAOK30.50914008
57DYRK30.49973306
58MAPK120.49543502
59ILK0.48310053
60DAPK20.48188521
61DDR20.45674514
62PRKG10.45438973
63CSNK1G30.44917290
64SRPK10.44680713
65SGK30.44203515
66YES10.44079635
67AURKA0.43029925
68MAP3K30.39756060
69MAP3K40.37266675
70ADRBK20.34416555
71CAMKK10.34299755
72STK38L0.34068717
73STK380.33120302
74PRKD20.30312386
75SCYL20.27225111
76PDGFRB0.26515022
77TEC0.26493180
78OXSR10.26228805
79GSK3A0.25871611
80CAMK2B0.25556366
81MAP2K70.24314918
82PRKCA0.23113651
83EPHA40.23035158
84PRKCE0.22966146
85ERBB20.21360457
86CAMK2D0.21359472
87PRKACA0.21089497
88PNCK0.20818299
89ATM0.19208111
90RPS6KA30.18000222
91PDGFRA0.17813429
92IGF1R0.16704565
93PKN10.16513728
94GSK3B0.16081129
95NEK60.15079472
96PRKACB0.14451520
97BRD40.14381031
98MAP3K120.13633048
99PRKD30.13335729
100RPS6KB10.12562245

Predicted pathways (KEGG)

RankGene SetZ-score
1Tight junction_Homo sapiens_hsa045304.38118702
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.72258707
3Nicotine addiction_Homo sapiens_hsa050332.66007157
4Regulation of autophagy_Homo sapiens_hsa041402.64575230
5Nitrogen metabolism_Homo sapiens_hsa009102.56705840
6Long-term depression_Homo sapiens_hsa047302.45928137
7Circadian entrainment_Homo sapiens_hsa047132.34747695
8Long-term potentiation_Homo sapiens_hsa047202.28041315
9Oxytocin signaling pathway_Homo sapiens_hsa049212.25992580
10Circadian rhythm_Homo sapiens_hsa047102.08486965
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.97112005
12Calcium signaling pathway_Homo sapiens_hsa040201.95442899
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.87449053
14cGMP-PKG signaling pathway_Homo sapiens_hsa040221.83614562
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78519103
16Dopaminergic synapse_Homo sapiens_hsa047281.76525912
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75803827
18Amphetamine addiction_Homo sapiens_hsa050311.75019509
19Pancreatic secretion_Homo sapiens_hsa049721.73901733
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61576212
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58210243
22Renin secretion_Homo sapiens_hsa049241.53640200
23Glutamatergic synapse_Homo sapiens_hsa047241.52601662
24Cholinergic synapse_Homo sapiens_hsa047251.48764192
25Glucagon signaling pathway_Homo sapiens_hsa049221.36255430
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35421509
27Gastric acid secretion_Homo sapiens_hsa049711.35361339
28Axon guidance_Homo sapiens_hsa043601.33493720
29Olfactory transduction_Homo sapiens_hsa047401.29973838
30Cocaine addiction_Homo sapiens_hsa050301.28959377
31Morphine addiction_Homo sapiens_hsa050321.28701969
32ErbB signaling pathway_Homo sapiens_hsa040121.27081880
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24482177
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.23556732
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20964622
36cAMP signaling pathway_Homo sapiens_hsa040241.13782830
37Wnt signaling pathway_Homo sapiens_hsa043101.13599066
38MicroRNAs in cancer_Homo sapiens_hsa052061.10326211
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09457085
40GABAergic synapse_Homo sapiens_hsa047271.07063342
41Lysine degradation_Homo sapiens_hsa003101.05913288
42Dilated cardiomyopathy_Homo sapiens_hsa054141.01476402
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01379035
44Inositol phosphate metabolism_Homo sapiens_hsa005620.96769715
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94499967
46AMPK signaling pathway_Homo sapiens_hsa041520.94008521
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93882129
48Insulin secretion_Homo sapiens_hsa049110.92540981
49Caffeine metabolism_Homo sapiens_hsa002320.90099213
50Focal adhesion_Homo sapiens_hsa045100.89385022
51Estrogen signaling pathway_Homo sapiens_hsa049150.88119339
52Serotonergic synapse_Homo sapiens_hsa047260.87332400
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83770810
54Platelet activation_Homo sapiens_hsa046110.83529016
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83074048
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83027922
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81561369
58Glioma_Homo sapiens_hsa052140.76897238
59mTOR signaling pathway_Homo sapiens_hsa041500.74752405
60Ether lipid metabolism_Homo sapiens_hsa005650.74351677
61Taste transduction_Homo sapiens_hsa047420.73905780
62Adherens junction_Homo sapiens_hsa045200.71385034
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69717285
64Tryptophan metabolism_Homo sapiens_hsa003800.67877247
65Salivary secretion_Homo sapiens_hsa049700.67134829
66GnRH signaling pathway_Homo sapiens_hsa049120.63638384
67Melanoma_Homo sapiens_hsa052180.63179686
68Hedgehog signaling pathway_Homo sapiens_hsa043400.62952780
69Fructose and mannose metabolism_Homo sapiens_hsa000510.62377738
70Starch and sucrose metabolism_Homo sapiens_hsa005000.62142738
71Arginine biosynthesis_Homo sapiens_hsa002200.60738529
72Insulin resistance_Homo sapiens_hsa049310.60502310
73ECM-receptor interaction_Homo sapiens_hsa045120.59833557
74RNA degradation_Homo sapiens_hsa030180.58679387
75Protein digestion and absorption_Homo sapiens_hsa049740.57783118
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57218674
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56504200
78mRNA surveillance pathway_Homo sapiens_hsa030150.56238128
79Type II diabetes mellitus_Homo sapiens_hsa049300.52195718
80Oocyte meiosis_Homo sapiens_hsa041140.51358137
81Phototransduction_Homo sapiens_hsa047440.50490252
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49018827
83Dorso-ventral axis formation_Homo sapiens_hsa043200.48463340
84Cardiac muscle contraction_Homo sapiens_hsa042600.47333223
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44827436
86Basal cell carcinoma_Homo sapiens_hsa052170.41735965
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41035512
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37991158
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37887112
90TGF-beta signaling pathway_Homo sapiens_hsa043500.37817053
91HIF-1 signaling pathway_Homo sapiens_hsa040660.37518999
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37433959
93Colorectal cancer_Homo sapiens_hsa052100.37376370
94Insulin signaling pathway_Homo sapiens_hsa049100.36283524
95MAPK signaling pathway_Homo sapiens_hsa040100.35937514
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35752227
97Endometrial cancer_Homo sapiens_hsa052130.35361121
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33413227
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.33267566
100Butanoate metabolism_Homo sapiens_hsa006500.33180277

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