RPSAP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.84119354
2viral transcription (GO:0019083)5.75760704
3translational termination (GO:0006415)5.52133343
4ribosomal small subunit biogenesis (GO:0042274)5.48406124
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.35779781
6maturation of SSU-rRNA (GO:0030490)5.31768445
7behavioral response to nicotine (GO:0035095)5.27020493
8pyrimidine nucleobase catabolic process (GO:0006208)5.18465873
9head development (GO:0060322)4.58946436
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.55132140
11cotranslational protein targeting to membrane (GO:0006613)4.51060480
12ATP synthesis coupled proton transport (GO:0015986)4.50076267
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50076267
14translational elongation (GO:0006414)4.49349985
15protein targeting to ER (GO:0045047)4.48577128
16establishment of mitochondrion localization (GO:0051654)4.38153178
17cellular protein complex disassembly (GO:0043624)4.30950678
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26300869
19chaperone-mediated protein transport (GO:0072321)4.24295952
20protein localization to endoplasmic reticulum (GO:0070972)4.21898738
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.21724362
22mitochondrion transport along microtubule (GO:0047497)4.21724362
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.15626677
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05267612
25nucleobase catabolic process (GO:0046113)4.02122728
26viral life cycle (GO:0019058)4.01991520
27regulation of cilium movement (GO:0003352)3.85423248
28neuron recognition (GO:0008038)3.69827713
29body morphogenesis (GO:0010171)3.66117393
30protein complex disassembly (GO:0043241)3.64619826
31regulation of microtubule-based movement (GO:0060632)3.62327892
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.58017222
33somite development (GO:0061053)3.56374430
34protein neddylation (GO:0045116)3.55575522
35base-excision repair, AP site formation (GO:0006285)3.51655149
36transmission of nerve impulse (GO:0019226)3.50965626
37macromolecular complex disassembly (GO:0032984)3.43121727
38translational initiation (GO:0006413)3.42071674
39axonal fasciculation (GO:0007413)3.40786593
40neurotransmitter-gated ion channel clustering (GO:0072578)3.40665292
41synaptic transmission, cholinergic (GO:0007271)3.39679854
42spinal cord development (GO:0021510)3.38942897
43epithelial cilium movement (GO:0003351)3.36725088
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28882879
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26794024
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.26794024
47NADH dehydrogenase complex assembly (GO:0010257)3.26794024
48axoneme assembly (GO:0035082)3.22805536
49embryonic body morphogenesis (GO:0010172)3.21127621
50axonemal dynein complex assembly (GO:0070286)3.18306484
51peptidyl-threonine dephosphorylation (GO:0035970)3.12822838
52cell-cell junction maintenance (GO:0045217)3.12333017
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12236999
54protein polyglutamylation (GO:0018095)3.10043538
55dendritic spine morphogenesis (GO:0060997)3.08799282
56respiratory electron transport chain (GO:0022904)3.04426466
57protein complex biogenesis (GO:0070271)3.03765974
58retinal ganglion cell axon guidance (GO:0031290)3.03074132
59electron transport chain (GO:0022900)3.02772761
60negative regulation of axon guidance (GO:1902668)3.02650036
61positive regulation of meiosis (GO:0045836)2.99206454
62negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97329060
63cellular ketone body metabolic process (GO:0046950)2.94533247
64nuclear-transcribed mRNA catabolic process (GO:0000956)2.92280305
65cell junction maintenance (GO:0034331)2.92096422
66pyrimidine nucleotide catabolic process (GO:0006244)2.90923254
67protein targeting to membrane (GO:0006612)2.89647585
68response to pheromone (GO:0019236)2.87069006
69camera-type eye morphogenesis (GO:0048593)2.85575041
70axon extension (GO:0048675)2.85427463
71ovulation cycle (GO:0042698)2.84501480
72ncRNA 3-end processing (GO:0043628)2.83690375
73positive regulation of meiotic cell cycle (GO:0051446)2.82317017
74GTP biosynthetic process (GO:0006183)2.80467151
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.80325506
76neuron projection extension involved in neuron projection guidance (GO:1902284)2.77198758
77axon extension involved in axon guidance (GO:0048846)2.77198758
78cell proliferation in forebrain (GO:0021846)2.75852531
79thalamus development (GO:0021794)2.75189490
80microtubule bundle formation (GO:0001578)2.74986319
81translation (GO:0006412)2.74080447
82mRNA catabolic process (GO:0006402)2.73706540
83ketone body metabolic process (GO:1902224)2.73612546
84mechanoreceptor differentiation (GO:0042490)2.71741803
85intraciliary transport (GO:0042073)2.71629777
86dendrite development (GO:0016358)2.70273509
87protein localization to cilium (GO:0061512)2.70215045
88neuron fate determination (GO:0048664)2.70013561
89synaptic transmission, glutamatergic (GO:0035249)2.67831198
90regulation of timing of cell differentiation (GO:0048505)2.67589367
91olfactory bulb development (GO:0021772)2.65609983
92mitochondrial respiratory chain complex assembly (GO:0033108)2.64179468
93nonmotile primary cilium assembly (GO:0035058)2.62562488
94inner ear receptor cell differentiation (GO:0060113)2.61030882
95urogenital system development (GO:0001655)2.60061985
96positive regulation of male gonad development (GO:2000020)2.59904275
97cochlea development (GO:0090102)2.58426522
98cilium movement (GO:0003341)2.58279055
99calcium ion-dependent exocytosis (GO:0017156)2.57775107
100genetic imprinting (GO:0071514)2.57013043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96077913
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.06260894
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65917336
4ZNF274_21170338_ChIP-Seq_K562_Hela2.58323699
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.54679920
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54210018
7VDR_22108803_ChIP-Seq_LS180_Human2.36809562
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.33477023
9IGF1R_20145208_ChIP-Seq_DFB_Human2.28948942
10REST_21632747_ChIP-Seq_MESCs_Mouse2.23585449
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.09775368
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03720524
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03614601
14GBX2_23144817_ChIP-Seq_PC3_Human2.01472787
15EST1_17652178_ChIP-ChIP_JURKAT_Human1.98376224
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90131953
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86275957
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83947773
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.81756839
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81235701
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78345978
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.72170300
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62090698
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.61876554
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.56471390
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53394234
27EWS_26573619_Chip-Seq_HEK293_Human1.52783019
28P300_19829295_ChIP-Seq_ESCs_Human1.50159411
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49905502
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48398325
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47615224
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47449419
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43041901
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.42417382
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42302684
36RNF2_27304074_Chip-Seq_NSC_Mouse1.41896596
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38502948
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37443439
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36130017
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33677643
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30234613
42MYC_18940864_ChIP-ChIP_HL60_Human1.29263250
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27914165
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.27561433
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27492559
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27492559
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.25676243
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.21620051
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21289202
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21075459
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19015921
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19015921
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18009084
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15467227
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15048432
56FUS_26573619_Chip-Seq_HEK293_Human1.11795190
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11383788
58TP53_22573176_ChIP-Seq_HFKS_Human1.11163701
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10889907
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.10055096
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.09993859
62TAF15_26573619_Chip-Seq_HEK293_Human1.07349696
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06931014
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.05936775
65IRF1_19129219_ChIP-ChIP_H3396_Human1.05244062
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05084497
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04933586
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02245825
69TTF2_22483619_ChIP-Seq_HELA_Human1.01868746
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01790447
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01639755
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00261954
73CTCF_27219007_Chip-Seq_Bcells_Human0.99972293
74SALL1_21062744_ChIP-ChIP_HESCs_Human0.99893178
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99060799
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99029270
77AR_25329375_ChIP-Seq_VCAP_Human0.98556304
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98335099
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96851255
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95840615
81MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95067715
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.94796482
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94498632
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94302558
85NCOR_22424771_ChIP-Seq_293T_Human0.93445768
86TCF4_22108803_ChIP-Seq_LS180_Human0.93399693
87ERA_21632823_ChIP-Seq_H3396_Human0.92677094
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.91955146
89CBP_20019798_ChIP-Seq_JUKART_Human0.91921562
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91921562
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91660554
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90633243
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.89859935
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.88393306
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88220350
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88125642
97ER_23166858_ChIP-Seq_MCF-7_Human0.87925354
98WDR5_24793694_ChIP-Seq_LNCAP_Human0.87573112
99RUNX2_22187159_ChIP-Seq_PCA_Human0.86695288
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.86598001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.65293573
2MP0006292_abnormal_olfactory_placode3.55914678
3MP0003122_maternal_imprinting3.24365921
4MP0003787_abnormal_imprinting3.23076379
5MP0001529_abnormal_vocalization2.98316424
6MP0002822_catalepsy2.92047907
7MP0001485_abnormal_pinna_reflex2.62509518
8MP0008789_abnormal_olfactory_epithelium2.51395115
9MP0004742_abnormal_vestibular_system2.41618659
10MP0003123_paternal_imprinting2.37043136
11MP0008877_abnormal_DNA_methylation2.31936477
12MP0000778_abnormal_nervous_system2.26274668
13MP0003136_yellow_coat_color2.26130016
14MP0005499_abnormal_olfactory_system2.25099290
15MP0005394_taste/olfaction_phenotype2.25099290
16MP0003121_genomic_imprinting2.12406416
17MP0002653_abnormal_ependyma_morphology2.08979651
18MP0006276_abnormal_autonomic_nervous2.04412505
19MP0002938_white_spotting1.99088368
20MP0005646_abnormal_pituitary_gland1.98747664
21MP0001293_anophthalmia1.97759651
22MP0002736_abnormal_nociception_after1.95934777
23MP0001188_hyperpigmentation1.92076830
24MP0003880_abnormal_central_pattern1.91320123
25MP0004142_abnormal_muscle_tone1.90263856
26MP0001968_abnormal_touch/_nociception1.89939280
27MP0000372_irregular_coat_pigmentation1.86835401
28MP0003315_abnormal_perineum_morphology1.82170132
29MP0009745_abnormal_behavioral_response1.70259348
30MP0002272_abnormal_nervous_system1.63817114
31MP0003635_abnormal_synaptic_transmissio1.61393811
32MP0001970_abnormal_pain_threshold1.58014367
33MP0003890_abnormal_embryonic-extraembry1.57306174
34MP0002733_abnormal_thermal_nociception1.49913822
35MP0002734_abnormal_mechanical_nocicepti1.49448614
36MP0009046_muscle_twitch1.46384821
37MP0004859_abnormal_synaptic_plasticity1.46000829
38MP0004885_abnormal_endolymph1.45460021
39MP0008875_abnormal_xenobiotic_pharmacok1.44783565
40MP0002735_abnormal_chemical_nociception1.43461560
41MP0000569_abnormal_digit_pigmentation1.43445214
42MP0005174_abnormal_tail_pigmentation1.41739630
43MP0002557_abnormal_social/conspecific_i1.39142590
44MP0005551_abnormal_eye_electrophysiolog1.36258242
45MP0000955_abnormal_spinal_cord1.33938673
46MP0002234_abnormal_pharynx_morphology1.29698567
47MP0004924_abnormal_behavior1.27487546
48MP0005386_behavior/neurological_phenoty1.27487546
49MP0002063_abnormal_learning/memory/cond1.26569445
50MP0002184_abnormal_innervation1.25360754
51MP0001486_abnormal_startle_reflex1.24725674
52MP0002102_abnormal_ear_morphology1.24290572
53MP0000049_abnormal_middle_ear1.23126606
54MP0002572_abnormal_emotion/affect_behav1.22218680
55MP0002095_abnormal_skin_pigmentation1.22173959
56MP0006072_abnormal_retinal_apoptosis1.20521374
57MP0002067_abnormal_sensory_capabilities1.19476886
58MP0003011_delayed_dark_adaptation1.17569040
59MP0000631_abnormal_neuroendocrine_gland1.17028362
60MP0009053_abnormal_anal_canal1.16754278
61MP0001986_abnormal_taste_sensitivity1.14458940
62MP0004145_abnormal_muscle_electrophysio1.10232159
63MP0003119_abnormal_digestive_system1.10177439
64MP0008872_abnormal_physiological_respon1.09796892
65MP0002882_abnormal_neuron_morphology1.09776472
66MP0010030_abnormal_orbit_morphology1.09241609
67MP0002064_seizures1.09174967
68MP0003646_muscle_fatigue1.08814260
69MP0000026_abnormal_inner_ear1.08329594
70MP0002752_abnormal_somatic_nervous1.07271765
71MP0003942_abnormal_urinary_system1.06655027
72MP0005645_abnormal_hypothalamus_physiol1.04257523
73MP0001905_abnormal_dopamine_level1.03622357
74MP0005187_abnormal_penis_morphology1.03503309
75MP0005195_abnormal_posterior_eye1.02510700
76MP0002638_abnormal_pupillary_reflex1.02429638
77MP0008569_lethality_at_weaning1.02125571
78MP0004270_analgesia1.02005680
79MP0004147_increased_porphyrin_level1.01022263
80MP0002163_abnormal_gland_morphology0.99365163
81MP0005423_abnormal_somatic_nervous0.97197071
82MP0000537_abnormal_urethra_morphology0.92998375
83MP0005084_abnormal_gallbladder_morpholo0.90711353
84MP0001440_abnormal_grooming_behavior0.90171793
85MP0002233_abnormal_nose_morphology0.89625552
86MP0005085_abnormal_gallbladder_physiolo0.88802055
87MP0003879_abnormal_hair_cell0.88541618
88MP0001963_abnormal_hearing_physiology0.87792632
89MP0001348_abnormal_lacrimal_gland0.87483143
90MP0004133_heterotaxia0.85877668
91MP0002152_abnormal_brain_morphology0.83824158
92MP0003861_abnormal_nervous_system0.83666109
93MP0005379_endocrine/exocrine_gland_phen0.81144392
94MP0001984_abnormal_olfaction0.79330313
95MP0002277_abnormal_respiratory_mucosa0.79165591
96MP0004811_abnormal_neuron_physiology0.79165380
97MP0002751_abnormal_autonomic_nervous0.75967539
98MP0001286_abnormal_eye_development0.75852336
99MP0003937_abnormal_limbs/digits/tail_de0.70589364
100MP0005377_hearing/vestibular/ear_phenot0.69727332

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.61561797
2Acute necrotizing encephalopathy (HP:0006965)3.98396977
3Pancreatic fibrosis (HP:0100732)3.70688406
4Agitation (HP:0000713)3.69470425
5Abnormality of the labia minora (HP:0012880)3.50116625
6Abnormal mitochondria in muscle tissue (HP:0008316)3.41060734
7Myokymia (HP:0002411)3.29843636
8Colon cancer (HP:0003003)3.27302353
9Septo-optic dysplasia (HP:0100842)3.23579350
10Acute encephalopathy (HP:0006846)3.22003129
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.16814060
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.16814060
13Progressive macrocephaly (HP:0004481)3.15974633
14True hermaphroditism (HP:0010459)3.07941324
15Abnormality of DNA repair (HP:0003254)2.98392218
16Type II lissencephaly (HP:0007260)2.97748126
17Pancreatic cysts (HP:0001737)2.90748026
18Molar tooth sign on MRI (HP:0002419)2.89044539
19Abnormality of midbrain morphology (HP:0002418)2.89044539
20Mitochondrial inheritance (HP:0001427)2.87787348
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85800385
22Abnormal respiratory motile cilium morphology (HP:0005938)2.78548470
23Abnormal respiratory epithelium morphology (HP:0012253)2.78548470
24Nephronophthisis (HP:0000090)2.78209622
25Abnormality of cells of the erythroid lineage (HP:0012130)2.68069827
26Optic nerve hypoplasia (HP:0000609)2.67729171
27Abnormality of the corticospinal tract (HP:0002492)2.66494920
28Retinal dysplasia (HP:0007973)2.65380953
29Optic disc pallor (HP:0000543)2.64769355
30Anophthalmia (HP:0000528)2.63570590
31Macrocytic anemia (HP:0001972)2.62471409
32Cystic liver disease (HP:0006706)2.60668613
33Chronic hepatic failure (HP:0100626)2.57785969
34Pendular nystagmus (HP:0012043)2.55732914
35Increased CSF lactate (HP:0002490)2.51747319
36Focal motor seizures (HP:0011153)2.44247634
37Sclerocornea (HP:0000647)2.43043811
38Bilateral microphthalmos (HP:0007633)2.41357231
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34552223
40Abnormality of the renal medulla (HP:0100957)2.32942261
41Hyperphosphatemia (HP:0002905)2.32617593
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31377304
43Pallor (HP:0000980)2.29525922
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27670528
45Lissencephaly (HP:0001339)2.23239547
46Adrenal hypoplasia (HP:0000835)2.21156387
47Anencephaly (HP:0002323)2.19942187
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.19803668
49Narrow forehead (HP:0000341)2.17156223
50Absent thumb (HP:0009777)2.15486501
51Restlessness (HP:0000711)2.14982540
52Cerebral edema (HP:0002181)2.14736370
53Fetal akinesia sequence (HP:0001989)2.13574303
54Urinary bladder sphincter dysfunction (HP:0002839)2.13435106
55Facial cleft (HP:0002006)2.10177346
56Hepatocellular necrosis (HP:0001404)2.08262191
57Asplenia (HP:0001746)2.07255902
58Congenital hepatic fibrosis (HP:0002612)2.06656325
59Medial flaring of the eyebrow (HP:0010747)2.05630364
60Postaxial foot polydactyly (HP:0001830)2.05146656
61Hypoplasia of the brainstem (HP:0002365)2.04492169
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04492169
63Male pseudohermaphroditism (HP:0000037)2.02193813
64Focal seizures (HP:0007359)1.98855755
65Progressive cerebellar ataxia (HP:0002073)1.98104433
66Broad alveolar ridges (HP:0000187)1.97920501
67Poor suck (HP:0002033)1.94827467
68Genetic anticipation (HP:0003743)1.94269908
69Pachygyria (HP:0001302)1.93920413
70Dynein arm defect of respiratory motile cilia (HP:0012255)1.91910923
71Absent/shortened dynein arms (HP:0200106)1.91910923
72Abnormality of the renal cortex (HP:0011035)1.91810898
73Holoprosencephaly (HP:0001360)1.91714906
74Hyperglycinemia (HP:0002154)1.89444692
75Optic nerve coloboma (HP:0000588)1.89274552
76Abnormal number of erythroid precursors (HP:0012131)1.87470462
77Stenosis of the external auditory canal (HP:0000402)1.87411214
78Abnormal respiratory motile cilium physiology (HP:0012261)1.85918189
79Abnormality of the renal collecting system (HP:0004742)1.85691501
80Leukodystrophy (HP:0002415)1.85291435
81Congenital stationary night blindness (HP:0007642)1.82607868
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.82346550
83Meningocele (HP:0002435)1.81849431
84Oligodactyly (hands) (HP:0001180)1.80791420
85Synostosis of carpal bones (HP:0005048)1.80271167
86Volvulus (HP:0002580)1.80229567
87Increased hepatocellular lipid droplets (HP:0006565)1.78211985
88Depressed nasal ridge (HP:0000457)1.77503088
89Papilledema (HP:0001085)1.76316772
90Amblyopia (HP:0000646)1.75322966
91Maternal diabetes (HP:0009800)1.73851225
92Abnormal rod and cone electroretinograms (HP:0008323)1.73838861
93Absent eyebrow (HP:0002223)1.70703094
94Bifid tongue (HP:0010297)1.70280553
95Renal cortical cysts (HP:0000803)1.69737884
96Gait imbalance (HP:0002141)1.68692156
97Growth hormone deficiency (HP:0000824)1.68546194
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66273453
99Small hand (HP:0200055)1.65769963
1003-Methylglutaconic aciduria (HP:0003535)1.65621286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.40230171
2CASK3.80619055
3EPHB23.58605514
4WNK33.44932254
5CDK193.36159160
6WNK43.33897854
7SIK22.88754921
8DYRK22.53406740
9MARK12.36127424
10PAK32.05576476
11ADRBK21.96515782
12NTRK21.89561991
13MINK11.83518555
14CAMKK21.73911518
15EPHA41.66679031
16TNIK1.66140601
17NUAK11.59726716
18VRK11.54243257
19PRKD31.53332227
20PNCK1.49654927
21FRK1.48472381
22MAP2K71.42569435
23PRKCG1.32192756
24NTRK31.31864469
25MAP3K111.30879188
26MAPK151.28855225
27STK391.24591863
28VRK21.24528372
29CAMK11.22715891
30TIE11.22385991
31PBK1.21709853
32KSR11.17581240
33MAPK131.16247422
34PINK11.12951737
35MATK1.11726135
36NEK21.09539991
37CSNK1G21.01901998
38TAOK31.01078267
39CAMK1D0.99495700
40GRK10.94675498
41CAMK1G0.90264608
42CAMKK10.90230536
43LRRK20.89291898
44MKNK20.86094215
45PIK3CA0.84001720
46PDK20.80137907
47WNK10.79917512
48CSNK1G30.74673879
49PTK60.74670935
50ERBB30.72684260
51STK110.72681646
52MAP3K40.71396416
53ZAK0.70198471
54PLK20.69758908
55ERBB20.67548936
56MAP4K20.65021229
57OXSR10.62457037
58PRKACA0.61538627
59STK40.60741138
60BMPR1B0.60690563
61TLK10.60013550
62PAK60.57552397
63CSNK1E0.57069681
64CSNK1G10.55438482
65CSNK1A1L0.53095864
66ADRBK10.52658847
67INSRR0.52363721
68PRKCH0.49812935
69CDK50.49253910
70BCR0.49044986
71PRKCI0.48767525
72SGK10.48675914
73PRKDC0.46639717
74LIMK10.46340880
75PRKCZ0.44747874
76BRAF0.44640470
77ICK0.44159224
78NME10.44094425
79PLK10.43581825
80PRKCQ0.41712725
81PRKCA0.41285728
82PLK30.40056240
83CSNK2A20.39940854
84KIT0.39496518
85TRIM280.39436361
86MAP3K90.39392327
87CSNK1A10.37857719
88RPS6KA30.37570905
89AURKA0.36090356
90TYRO30.35879569
91PKN10.35817813
92SGK4940.35366752
93SGK2230.35366752
94CDK11A0.33019832
95PAK10.32476967
96ATM0.31959231
97PRKCE0.30476521
98CAMK2A0.29807265
99PRKACG0.29775874
100MARK20.29672756

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.15150587
2Oxidative phosphorylation_Homo sapiens_hsa001903.98550183
3Parkinsons disease_Homo sapiens_hsa050123.41339912
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11886730
5Cardiac muscle contraction_Homo sapiens_hsa042602.58332089
6Huntingtons disease_Homo sapiens_hsa050162.56192844
7RNA polymerase_Homo sapiens_hsa030202.55268130
8Nicotine addiction_Homo sapiens_hsa050332.52082819
9Alzheimers disease_Homo sapiens_hsa050102.39137235
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35322264
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27581208
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14798834
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08896453
14Steroid biosynthesis_Homo sapiens_hsa001002.00043416
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82276123
16Phototransduction_Homo sapiens_hsa047441.78924393
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73564742
18Butanoate metabolism_Homo sapiens_hsa006501.42120331
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31803884
20Peroxisome_Homo sapiens_hsa041461.29822196
21Morphine addiction_Homo sapiens_hsa050321.29504387
22Protein export_Homo sapiens_hsa030601.28613050
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26771080
24Glutamatergic synapse_Homo sapiens_hsa047241.25250191
25GABAergic synapse_Homo sapiens_hsa047271.21009957
26Axon guidance_Homo sapiens_hsa043601.19489955
27Basal transcription factors_Homo sapiens_hsa030221.18177527
28Homologous recombination_Homo sapiens_hsa034401.13845169
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13706080
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08360123
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05869526
32Fanconi anemia pathway_Homo sapiens_hsa034601.05298161
33Linoleic acid metabolism_Homo sapiens_hsa005911.02589766
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01750889
35Nucleotide excision repair_Homo sapiens_hsa034201.00324228
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95541935
37Cholinergic synapse_Homo sapiens_hsa047250.94028544
38Synaptic vesicle cycle_Homo sapiens_hsa047210.93511135
39Serotonergic synapse_Homo sapiens_hsa047260.92378636
40Insulin secretion_Homo sapiens_hsa049110.92117952
41RNA degradation_Homo sapiens_hsa030180.87303804
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86144383
43Dopaminergic synapse_Homo sapiens_hsa047280.85880138
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84280270
45Taste transduction_Homo sapiens_hsa047420.84081437
46Circadian entrainment_Homo sapiens_hsa047130.82824146
47Basal cell carcinoma_Homo sapiens_hsa052170.82616683
48Propanoate metabolism_Homo sapiens_hsa006400.82368633
49Sulfur relay system_Homo sapiens_hsa041220.80938414
50Cocaine addiction_Homo sapiens_hsa050300.80057133
51Proteasome_Homo sapiens_hsa030500.79696377
52Nitrogen metabolism_Homo sapiens_hsa009100.78732501
53Collecting duct acid secretion_Homo sapiens_hsa049660.78177093
54beta-Alanine metabolism_Homo sapiens_hsa004100.77221541
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.77140964
56Glycerolipid metabolism_Homo sapiens_hsa005610.75888092
57Purine metabolism_Homo sapiens_hsa002300.75183165
58Chemical carcinogenesis_Homo sapiens_hsa052040.74528140
59Pyrimidine metabolism_Homo sapiens_hsa002400.74493012
60Arginine and proline metabolism_Homo sapiens_hsa003300.72210868
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71627749
62Retinol metabolism_Homo sapiens_hsa008300.70847451
63Metabolic pathways_Homo sapiens_hsa011000.70673574
64Olfactory transduction_Homo sapiens_hsa047400.70519666
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.68136174
66Fatty acid metabolism_Homo sapiens_hsa012120.68038653
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.66040269
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65896873
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65327628
70Pyruvate metabolism_Homo sapiens_hsa006200.64608260
71Non-homologous end-joining_Homo sapiens_hsa034500.63694627
72Caffeine metabolism_Homo sapiens_hsa002320.62415002
73Dorso-ventral axis formation_Homo sapiens_hsa043200.61761129
74Hedgehog signaling pathway_Homo sapiens_hsa043400.60549841
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59248138
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58351807
77Tryptophan metabolism_Homo sapiens_hsa003800.57544300
78Ovarian steroidogenesis_Homo sapiens_hsa049130.55249420
79Base excision repair_Homo sapiens_hsa034100.55230560
80Melanoma_Homo sapiens_hsa052180.53039351
81Spliceosome_Homo sapiens_hsa030400.48946518
82Alcoholism_Homo sapiens_hsa050340.48772158
83Fatty acid degradation_Homo sapiens_hsa000710.48368407
84Long-term depression_Homo sapiens_hsa047300.47466191
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47349436
86RNA transport_Homo sapiens_hsa030130.44459782
87Fat digestion and absorption_Homo sapiens_hsa049750.43350001
88Amphetamine addiction_Homo sapiens_hsa050310.41626580
89cAMP signaling pathway_Homo sapiens_hsa040240.36639571
90One carbon pool by folate_Homo sapiens_hsa006700.35976071
91Asthma_Homo sapiens_hsa053100.35966692
92Hippo signaling pathway_Homo sapiens_hsa043900.32849219
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31286261
94Ether lipid metabolism_Homo sapiens_hsa005650.30488270
95Starch and sucrose metabolism_Homo sapiens_hsa005000.29226850
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29083097
97Notch signaling pathway_Homo sapiens_hsa043300.28501326
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.27928175
99Ras signaling pathway_Homo sapiens_hsa040140.26087363
100Gap junction_Homo sapiens_hsa045400.25856597

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