RPSAP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle tissue regeneration (GO:0043403)9.78739263
2negative regulation of skeletal muscle tissue development (GO:0048642)9.39447697
3regulation of skeletal muscle contraction (GO:0014819)9.26553658
4response to muscle activity (GO:0014850)8.73801009
5actin-mediated cell contraction (GO:0070252)8.16049636
6cellular response to dexamethasone stimulus (GO:0071549)6.75427975
7response to activity (GO:0014823)6.25983729
8response to dexamethasone (GO:0071548)6.23866579
9striated muscle adaptation (GO:0014888)5.96854650
10actin filament-based movement (GO:0030048)5.90001970
11protein K6-linked ubiquitination (GO:0085020)5.53224385
12dosage compensation (GO:0007549)5.41522460
13negative regulation of organelle assembly (GO:1902116)5.18787241
14muscle adaptation (GO:0043500)4.82248894
15regulation of muscle hypertrophy (GO:0014743)4.82064724
16negative regulation of fatty acid biosynthetic process (GO:0045717)4.66053598
17regulation of DNA methylation (GO:0044030)4.57317830
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.38682916
19myotube cell development (GO:0014904)4.34589921
20skeletal muscle contraction (GO:0003009)4.31504668
21regulation of gene expression by genetic imprinting (GO:0006349)4.30672078
22protein trimerization (GO:0070206)4.28791708
23positive regulation of histone H3-K4 methylation (GO:0051571)4.28579429
24muscle organ development (GO:0007517)4.03810960
25response to electrical stimulus (GO:0051602)3.99752398
26muscle structure development (GO:0061061)3.98728313
27dendritic spine morphogenesis (GO:0060997)3.95446785
28regulation of relaxation of muscle (GO:1901077)3.91386873
29tissue regeneration (GO:0042246)3.79172167
30negative regulation of histone methylation (GO:0031061)3.77747993
31skeletal muscle fiber development (GO:0048741)3.72170514
32response to inactivity (GO:0014854)3.71356986
33cellular response to ketone (GO:1901655)3.64686071
34negative regulation of striated muscle tissue development (GO:0045843)3.50659641
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.48038762
36genetic imprinting (GO:0071514)3.45581692
37response to testosterone (GO:0033574)3.45037688
38negative regulation of muscle tissue development (GO:1901862)3.41671368
39protein polyglutamylation (GO:0018095)3.41050184
40heparin metabolic process (GO:0030202)3.39679689
41heparin biosynthetic process (GO:0030210)3.39679689
42ganglion development (GO:0061548)3.39063587
43growth hormone secretion (GO:0030252)3.38529640
44negative regulation of histone acetylation (GO:0035067)3.37090496
45cellular response to glucocorticoid stimulus (GO:0071385)3.34892467
46regulation of histone H3-K9 methylation (GO:0051570)3.32989829
47sarcoplasmic reticulum calcium ion transport (GO:0070296)3.32708374
48muscle system process (GO:0003012)3.32477626
49regulation of centriole replication (GO:0046599)3.31014355
50positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.29891330
51negative regulation of muscle organ development (GO:0048635)3.24743165
52auditory behavior (GO:0031223)3.21327944
53muscle contraction (GO:0006936)3.19184352
54negative regulation of peptidyl-lysine acetylation (GO:2000757)3.18210447
55DNA damage response, signal transduction resulting in transcription (GO:0042772)3.14987157
56cerebral cortex neuron differentiation (GO:0021895)3.10518650
57cellular response to corticosteroid stimulus (GO:0071384)3.09058169
58negative regulation of fatty acid metabolic process (GO:0045922)3.07695468
59regulation of timing of cell differentiation (GO:0048505)3.06429034
60lung secretory cell differentiation (GO:0061140)3.04484334
61regulation of synapse structural plasticity (GO:0051823)3.00274942
62response to folic acid (GO:0051593)2.79883621
63viral genome replication (GO:0019079)2.73288042
64synaptic vesicle maturation (GO:0016188)2.67944491
65positive regulation of growth hormone secretion (GO:0060124)2.66731723
66calcium ion import (GO:0070509)2.64772381
67neurotransmitter-gated ion channel clustering (GO:0072578)2.63861832
68negative regulation of protein acetylation (GO:1901984)2.57885459
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56873685
70secondary heart field specification (GO:0003139)2.56689969
71heart field specification (GO:0003128)2.56689969
72muscle fiber development (GO:0048747)2.54930894
73response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53195901
74myoblast fusion (GO:0007520)2.51154900
75striated muscle contraction (GO:0006941)2.51146212
76regulation of development, heterochronic (GO:0040034)2.50436809
77multicellular organismal movement (GO:0050879)2.49715609
78musculoskeletal movement (GO:0050881)2.49715609
79dendritic spine organization (GO:0097061)2.48380647
80regulation of transcription involved in cell fate commitment (GO:0060850)2.47312386
81protein localization to microtubule (GO:0035372)2.43810116
82negative regulation of cAMP-mediated signaling (GO:0043951)2.43381242
83negative regulation of developmental growth (GO:0048640)2.40376391
84postsynaptic membrane organization (GO:0001941)2.39014690
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33721620
86mechanosensory behavior (GO:0007638)2.33579058
87postreplication repair (GO:0006301)2.32962543
88negative regulation of oligodendrocyte differentiation (GO:0048715)2.32297825
89muscle cell cellular homeostasis (GO:0046716)2.29061489
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.28685151
91regulation of muscle system process (GO:0090257)2.28463228
92embryonic cranial skeleton morphogenesis (GO:0048701)2.27109448
93regulation of striated muscle contraction (GO:0006942)2.25711366
94response to gravity (GO:0009629)15.3541719
95skeletal muscle adaptation (GO:0043501)13.3325010
96striated muscle atrophy (GO:0014891)12.9468311
97negative regulation of muscle hypertrophy (GO:0014741)11.7698655
98muscle atrophy (GO:0014889)11.5458702
99muscle filament sliding (GO:0030049)10.0040176
100actin-myosin filament sliding (GO:0033275)10.0040176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human7.82757217
2EZH2_22144423_ChIP-Seq_EOC_Human5.98827014
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.74743419
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.64476378
5TAF15_26573619_Chip-Seq_HEK293_Human4.03306784
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68003207
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53874191
8AR_21572438_ChIP-Seq_LNCaP_Human3.39919402
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.13049962
10FUS_26573619_Chip-Seq_HEK293_Human2.73617035
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.68548856
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.50140211
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.49697348
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48186060
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31205809
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09876396
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04579475
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94848802
19GBX2_23144817_ChIP-Seq_PC3_Human1.85935404
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81817216
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.80512773
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.77601958
23REST_21632747_ChIP-Seq_MESCs_Mouse1.77241414
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74495124
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74443056
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72540688
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70235931
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70116211
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70116211
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.62560827
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62392571
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.60917115
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57765729
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52517894
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45950333
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45514389
37TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44247601
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43198151
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41345369
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40429014
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37304111
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.36533473
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.35346433
44MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.34810450
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33938546
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32663980
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32663980
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32663980
49RXR_22108803_ChIP-Seq_LS180_Human1.30777357
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25757860
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24063463
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20746998
53KDM2B_26808549_Chip-Seq_REH_Human1.18177043
54SOX9_26525672_Chip-Seq_HEART_Mouse1.15721708
55GATA1_22025678_ChIP-Seq_K562_Human1.15588423
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14821479
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12780598
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12726576
59SMAD4_21799915_ChIP-Seq_A2780_Human1.12714203
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.12513965
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12192942
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11912441
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09144003
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08836861
65TP53_22573176_ChIP-Seq_HFKS_Human1.07853615
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.03871908
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03265572
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03113012
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02764981
70ER_23166858_ChIP-Seq_MCF-7_Human1.02022043
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00665988
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00541701
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00321977
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99181594
75PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98338678
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97205455
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97205455
78STAT3_23295773_ChIP-Seq_U87_Human0.97132795
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94496953
80RING1B_27294783_Chip-Seq_ESCs_Mouse0.89678199
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87021031
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86346924
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85249571
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.83764939
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81638073
86MYC_27129775_Chip-Seq_CORNEA_Mouse0.81283511
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.80599853
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80139474
89TCF4_23295773_ChIP-Seq_U87_Human0.79892568
90FLI1_21867929_ChIP-Seq_TH2_Mouse0.79719637
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79017349
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78142766
93RNF2_27304074_Chip-Seq_NSC_Mouse0.78002234
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.77905824
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.77551686
96DROSHA_22980978_ChIP-Seq_HELA_Human0.77020338
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76913130
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76695558
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76620730
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74004235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.27960022
2MP0000747_muscle_weakness5.19483349
3MP0002089_abnormal_postnatal_growth/wei4.63575952
4MP0003705_abnormal_hypodermis_morpholog4.10666701
5MP0004036_abnormal_muscle_relaxation3.96848042
6MP0002269_muscular_atrophy3.53529609
7MP0000749_muscle_degeneration3.37428141
8MP0000759_abnormal_skeletal_muscle3.34326965
9MP0000566_synostosis3.18807208
10MP0004270_analgesia3.15686645
11MP0005083_abnormal_biliary_tract2.99581415
12MP0002108_abnormal_muscle_morphology2.78244736
13MP0002822_catalepsy2.73570663
14MP0004087_abnormal_muscle_fiber2.55778064
15MP0002106_abnormal_muscle_physiology2.49039257
16MP0005620_abnormal_muscle_contractility2.37384219
17MP0003959_abnormal_lean_body2.07481214
18MP0005369_muscle_phenotype1.96395770
19MP0000751_myopathy1.87589588
20MP0009780_abnormal_chondrocyte_physiolo1.83305937
21MP0003787_abnormal_imprinting1.72908061
22MP0008789_abnormal_olfactory_epithelium1.69294058
23MP0000750_abnormal_muscle_regeneration1.63913643
24MP0002638_abnormal_pupillary_reflex1.62183051
25MP0000427_abnormal_hair_cycle1.60057764
26MP0002095_abnormal_skin_pigmentation1.53709861
27MP0001968_abnormal_touch/_nociception1.50457497
28MP0002896_abnormal_bone_mineralization1.49323596
29MP0000733_abnormal_muscle_development1.47249190
30MP0000778_abnormal_nervous_system1.45722314
31MP0003646_muscle_fatigue1.43990997
32MP0006072_abnormal_retinal_apoptosis1.43073851
33MP0002734_abnormal_mechanical_nocicepti1.32766707
34MP0005423_abnormal_somatic_nervous1.32125606
35MP0000049_abnormal_middle_ear1.30623177
36MP0003045_fibrosis1.28647407
37MP0004130_abnormal_muscle_cell1.26659141
38MP0002736_abnormal_nociception_after1.25616441
39MP0000372_irregular_coat_pigmentation1.19920184
40MP0003937_abnormal_limbs/digits/tail_de1.16067597
41MP0004142_abnormal_muscle_tone1.15257199
42MP0000013_abnormal_adipose_tissue1.11095889
43MP0004484_altered_response_of1.04057848
44MP0003950_abnormal_plasma_membrane1.01929285
45MP0003880_abnormal_central_pattern1.01654203
46MP0005499_abnormal_olfactory_system1.00964913
47MP0005394_taste/olfaction_phenotype1.00964913
48MP0009745_abnormal_behavioral_response1.00302088
49MP0002733_abnormal_thermal_nociception0.99687247
50MP0001529_abnormal_vocalization0.97566053
51MP0005646_abnormal_pituitary_gland0.96447986
52MP0000631_abnormal_neuroendocrine_gland0.95010039
53MP0000470_abnormal_stomach_morphology0.93009556
54MP0009250_abnormal_appendicular_skeleto0.91440403
55MP0001905_abnormal_dopamine_level0.89058073
56MP0004885_abnormal_endolymph0.88888387
57MP0004084_abnormal_cardiac_muscle0.87934591
58MP0000955_abnormal_spinal_cord0.84861883
59MP0003635_abnormal_synaptic_transmissio0.82426987
60MP0002837_dystrophic_cardiac_calcinosis0.81762290
61MP0005386_behavior/neurological_phenoty0.80718077
62MP0004924_abnormal_behavior0.80718077
63MP0005167_abnormal_blood-brain_barrier0.79413795
64MP0001943_abnormal_respiration0.77717838
65MP0006276_abnormal_autonomic_nervous0.76998287
66MP0003755_abnormal_palate_morphology0.76443362
67MP0002184_abnormal_innervation0.76159106
68MP0003123_paternal_imprinting0.75666317
69MP0005645_abnormal_hypothalamus_physiol0.75207901
70MP0000467_abnormal_esophagus_morphology0.74389486
71MP0002114_abnormal_axial_skeleton0.74141661
72MP0003385_abnormal_body_wall0.72151262
73MP0004215_abnormal_myocardial_fiber0.71705819
74MP0003786_premature_aging0.68698651
75MP0000537_abnormal_urethra_morphology0.66844386
76MP0003938_abnormal_ear_development0.66706972
77MP0001502_abnormal_circadian_rhythm0.66533712
78MP0001661_extended_life_span0.65932691
79MP0002066_abnormal_motor_capabilities/c0.65676285
80MP0008770_decreased_survivor_rate0.65640085
81MP0004811_abnormal_neuron_physiology0.65338369
82MP0002067_abnormal_sensory_capabilities0.64617476
83MP0004043_abnormal_pH_regulation0.64603631
84MP0002557_abnormal_social/conspecific_i0.63287452
85MP0001486_abnormal_startle_reflex0.63283447
86MP0005452_abnormal_adipose_tissue0.62965933
87MP0001849_ear_inflammation0.61721859
88MP0002277_abnormal_respiratory_mucosa0.61530888
89MP0005334_abnormal_fat_pad0.61019795
90MP0000569_abnormal_digit_pigmentation0.60453995
91MP0002115_abnormal_skeleton_extremities0.59972164
92MP0002064_seizures0.59839911
93MP0002069_abnormal_eating/drinking_beha0.59687561
94MP0001243_abnormal_dermal_layer0.59047279
95MP0002272_abnormal_nervous_system0.58741196
96MP0001970_abnormal_pain_threshold0.58489418
97MP0008057_abnormal_DNA_replication0.58133387
98MP0002735_abnormal_chemical_nociception0.57501595
99MP0002063_abnormal_learning/memory/cond0.55659869
100MP0003861_abnormal_nervous_system0.54483577

Predicted human phenotypes

RankGene SetZ-score
1Mask-like facies (HP:0000298)7.41165028
2Distal arthrogryposis (HP:0005684)7.33714161
3Exercise-induced myalgia (HP:0003738)7.20787469
4Nemaline bodies (HP:0003798)7.06826275
5Round ear (HP:0100830)6.80704742
6Calcaneovalgus deformity (HP:0001848)6.34816283
7Ulnar deviation of the wrist (HP:0003049)6.26154759
8Hyperkalemia (HP:0002153)5.87839080
9Muscle fiber inclusion bodies (HP:0100299)5.75114473
10Absent phalangeal crease (HP:0006109)5.74321625
11Deformed tarsal bones (HP:0008119)5.69345946
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.68098951
13Abnormal finger flexion creases (HP:0006143)4.83623035
14Periorbital edema (HP:0100539)4.81203180
15Facial edema (HP:0000282)4.61458531
16Type 1 muscle fiber predominance (HP:0003803)4.60800796
17Myopathic facies (HP:0002058)4.43452905
18Myoglobinuria (HP:0002913)3.97055020
19Exercise-induced muscle cramps (HP:0003710)3.79806398
20Neoplasm of the heart (HP:0100544)3.39302659
21Abnormality of potassium homeostasis (HP:0011042)3.28775931
22Difficulty running (HP:0009046)3.26154920
23Abnormality of the calcaneus (HP:0008364)3.21545095
24Down-sloping shoulders (HP:0200021)3.14277245
25Myotonia (HP:0002486)3.12275612
26Decreased circulating renin level (HP:0003351)2.98696429
27Metatarsus adductus (HP:0001840)2.93135774
28Nonprogressive disorder (HP:0003680)2.92276438
29Rhabdomyolysis (HP:0003201)2.66041146
30Increased connective tissue (HP:0009025)2.64862770
31Macroorchidism (HP:0000053)2.48954225
32Abnormality of the peritoneum (HP:0002585)2.39955113
33Hyperphosphatemia (HP:0002905)2.39685177
34Fibular aplasia (HP:0002990)2.29205444
35Bell-shaped thorax (HP:0001591)2.28043936
36Hypoventilation (HP:0002791)2.22670618
37Abnormality of the parietal bone (HP:0002696)2.22602988
38Intellectual disability, moderate (HP:0002342)2.21404969
39Muscle stiffness (HP:0003552)2.19133584
40Abnormality of the columella (HP:0009929)2.18867767
413-Methylglutaconic aciduria (HP:0003535)2.14843148
42Obstructive sleep apnea (HP:0002870)2.13159280
43Broad metatarsal (HP:0001783)2.10404028
44Abnormality of chloride homeostasis (HP:0011422)2.08612889
45Action tremor (HP:0002345)2.07140485
46Muscle hypertrophy of the lower extremities (HP:0008968)2.04021337
47Palpebral edema (HP:0100540)10.2020341
48Hypoplastic ischia (HP:0003175)1.98082873
49Microglossia (HP:0000171)1.96837138
502-3 toe syndactyly (HP:0004691)1.95049976
51Hypokalemia (HP:0002900)1.93034669
52Increased variability in muscle fiber diameter (HP:0003557)1.90923385
53Supernumerary ribs (HP:0005815)1.82755590
54Oligomenorrhea (HP:0000876)1.81674682
55Malignant hyperthermia (HP:0002047)1.80349618
56Menstrual irregularities (HP:0000858)1.76703199
57Coronal craniosynostosis (HP:0004440)1.74724351
58Broad-based gait (HP:0002136)1.74151514
59Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70619624
60Tarsal synostosis (HP:0008368)1.69553308
61Synostosis involving bones of the lower limbs (HP:0009138)1.69050263
62Synostosis involving bones of the feet (HP:0009140)1.69050263
63Supernumerary bones of the axial skeleton (HP:0009144)1.66487693
64Reduced subcutaneous adipose tissue (HP:0003758)1.66316524
65Abnormality of skeletal muscle fiber size (HP:0012084)1.65809879
66Delayed CNS myelination (HP:0002188)1.65143953
67Abnormality of incisor morphology (HP:0011063)1.64515759
68Broad hallux (HP:0010055)1.64465946
69Wrist flexion contracture (HP:0001239)1.62154074
70Abnormality of the ischium (HP:0003174)1.60457195
71Generalized muscle weakness (HP:0003324)1.60112817
72Shallow orbits (HP:0000586)1.59149268
73Type 2 muscle fiber atrophy (HP:0003554)1.55814155
74Hypoplastic iliac wings (HP:0002866)1.55787169
75Enlarged penis (HP:0000040)1.54062842
76Narrow palate (HP:0000189)1.51460816
77Mesomelia (HP:0003027)1.51097033
78Increased purine levels (HP:0004368)1.50770966
79Hyperuricemia (HP:0002149)1.50770966
80Metabolic acidosis (HP:0001942)1.50571139
81Nasolacrimal duct obstruction (HP:0000579)1.49072254
82Symphalangism affecting the phalanges of the hand (HP:0009773)1.48943901
83Poor eye contact (HP:0000817)1.48018906
84Stenosis of the external auditory canal (HP:0000402)1.47366865
85Abnormal hair whorl (HP:0010721)1.45440106
86Progressive cerebellar ataxia (HP:0002073)1.40608126
87Shawl scrotum (HP:0000049)1.40514878
88Rectal prolapse (HP:0002035)1.40365346
89Sleep apnea (HP:0010535)1.37340810
90Abnormality of hair growth rate (HP:0011363)1.34281352
91Slow-growing hair (HP:0002217)1.34281352
92Adducted thumb (HP:0001181)1.33567205
93Absent speech (HP:0001344)1.33321143
94Gout (HP:0001997)1.32125828
95Agitation (HP:0000713)1.31630299
96Muscle fiber atrophy (HP:0100295)1.30973660
97Paralysis (HP:0003470)1.28952192
98Ulnar deviation of finger (HP:0009465)1.28685891
99Urinary bladder sphincter dysfunction (HP:0002839)1.28453601
100Subaortic stenosis (HP:0001682)1.28414369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG15.83148861
2PHKG25.83148861
3OBSCN3.95548839
4TIE13.86924431
5WNK43.03378231
6TNIK2.99905722
7TYRO32.94347038
8CASK2.66451052
9CAMK1D2.56112525
10MAPK132.17767497
11WNK12.13495095
12CAMK1G2.08909774
13MARK11.98667402
14CAMKK21.89053991
15IRAK11.84632262
16JAK31.74559186
17DYRK1B1.73245721
18PIK3CA1.66134854
19FGFR21.64064128
20EPHB21.63857670
21PIK3CG1.41789660
22DYRK21.27841307
23PAK61.27263988
24CHEK21.16516952
25MAP3K121.11434270
26CAMKK11.09303764
27CDK41.07930851
28CAMK2G1.07161537
29LIMK11.06814403
30MOS1.06793254
31AURKA0.98086699
32NTRK20.97367671
33DDR20.97029104
34PRKD30.95874098
35DMPK0.94760886
36MAPK120.89312088
37NLK0.89092670
38MAP2K20.84985251
39NUAK10.83841343
40CSNK1G20.83517229
41RPS6KA20.82169732
42PINK10.81699971
43MARK20.80878438
44FGFR30.80108269
45CAMK40.79857006
46MAPK70.77281191
47SGK2230.75191249
48SGK4940.75191249
49SGK10.73561472
50CAMK10.71040242
51SGK20.69688452
52SCYL20.69327538
53PRKG10.66747392
54LMTK20.65417185
55STK390.63850286
56TAOK30.62853115
57CCNB10.62578656
58FRK0.61762597
59DYRK1A0.60848836
60MARK30.58730034
61TRIB30.54616791
62CSNK1A1L0.53973219
63TRPM70.53091240
64NTRK10.52669549
65TXK0.52205453
66CSNK1G10.52187554
67DYRK30.51964173
68MUSK0.51680182
69STK110.49183495
70SGK30.48799341
71TRIM280.48144936
72ILK0.47182950
73FES0.46593812
74BRD40.45796556
75CDK50.45603110
76DAPK20.45540370
77RPS6KA30.45451367
78BMPR1B0.41046055
79PRKD20.39976421
80EIF2AK20.39360607
81TEC0.39134127
82PRKACB0.36870204
83CDK120.35712682
84PKN10.33557734
85CSNK1G30.33372449
86MAP2K40.33055458
87STK30.32262852
88OXSR10.28948272
89INSRR0.28787760
90MAP3K70.26637443
91SIK20.26115690
92TESK20.25242504
93PRKDC0.25048435
94PRKACA0.23590479
95MAPK80.23511835
96TESK10.23400658
97AKT10.23075991
98MINK10.22564067
99PRKCE0.21758203
100RPS6KA60.21071439

Predicted pathways (KEGG)

RankGene SetZ-score
1Tight junction_Homo sapiens_hsa045305.03071726
2Regulation of autophagy_Homo sapiens_hsa041403.30346003
3Oxytocin signaling pathway_Homo sapiens_hsa049212.53188367
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.36935485
5Circadian entrainment_Homo sapiens_hsa047131.99579952
6Dopaminergic synapse_Homo sapiens_hsa047281.95701876
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95601121
8Gastric acid secretion_Homo sapiens_hsa049711.94339039
9Renin secretion_Homo sapiens_hsa049241.93475994
10Calcium signaling pathway_Homo sapiens_hsa040201.91074090
11Ribosome_Homo sapiens_hsa030101.88677554
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.87492585
13Long-term depression_Homo sapiens_hsa047301.79981782
14Glucagon signaling pathway_Homo sapiens_hsa049221.78172328
15Wnt signaling pathway_Homo sapiens_hsa043101.76791158
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.74783235
17Insulin secretion_Homo sapiens_hsa049111.72395040
18Morphine addiction_Homo sapiens_hsa050321.70017747
19Hedgehog signaling pathway_Homo sapiens_hsa043401.69438771
20Long-term potentiation_Homo sapiens_hsa047201.69319039
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65097662
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59999111
23Cardiac muscle contraction_Homo sapiens_hsa042601.55897808
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45466918
25Cholinergic synapse_Homo sapiens_hsa047251.45100247
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.44982718
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44921676
28Dilated cardiomyopathy_Homo sapiens_hsa054141.44023205
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41427660
30Nitrogen metabolism_Homo sapiens_hsa009101.35439772
31Adherens junction_Homo sapiens_hsa045201.34418828
32Arginine biosynthesis_Homo sapiens_hsa002201.32537501
33GABAergic synapse_Homo sapiens_hsa047271.31910490
34mRNA surveillance pathway_Homo sapiens_hsa030151.31678155
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31471022
36Amphetamine addiction_Homo sapiens_hsa050311.27199994
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24919237
38MAPK signaling pathway_Homo sapiens_hsa040101.12680661
39Oocyte meiosis_Homo sapiens_hsa041141.12056996
40Basal cell carcinoma_Homo sapiens_hsa052171.11286478
41Circadian rhythm_Homo sapiens_hsa047101.11139574
42Phototransduction_Homo sapiens_hsa047441.11029160
43Estrogen signaling pathway_Homo sapiens_hsa049151.10749968
44Axon guidance_Homo sapiens_hsa043601.09293428
45Nicotine addiction_Homo sapiens_hsa050331.08400124
46ErbB signaling pathway_Homo sapiens_hsa040121.00364451
47cAMP signaling pathway_Homo sapiens_hsa040240.93863827
48Melanogenesis_Homo sapiens_hsa049160.93849386
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92912472
50Serotonergic synapse_Homo sapiens_hsa047260.92436867
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88693165
52AMPK signaling pathway_Homo sapiens_hsa041520.86342205
53Olfactory transduction_Homo sapiens_hsa047400.86183223
54GnRH signaling pathway_Homo sapiens_hsa049120.84635136
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84049359
56Glutamatergic synapse_Homo sapiens_hsa047240.83749520
57Platelet activation_Homo sapiens_hsa046110.81327063
58Salivary secretion_Homo sapiens_hsa049700.76945669
59Synaptic vesicle cycle_Homo sapiens_hsa047210.74944552
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71703703
61Pancreatic secretion_Homo sapiens_hsa049720.69263057
62Glioma_Homo sapiens_hsa052140.68779457
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66715502
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64275575
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63119852
66Spliceosome_Homo sapiens_hsa030400.61586350
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.60651433
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59806521
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58845043
70Gap junction_Homo sapiens_hsa045400.58500150
71Glutathione metabolism_Homo sapiens_hsa004800.58423305
72Endocytosis_Homo sapiens_hsa041440.58422986
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.57270802
74Alzheimers disease_Homo sapiens_hsa050100.56735693
75T cell receptor signaling pathway_Homo sapiens_hsa046600.56646441
76Insulin signaling pathway_Homo sapiens_hsa049100.55136239
77Endometrial cancer_Homo sapiens_hsa052130.54206143
78RNA degradation_Homo sapiens_hsa030180.52532968
79Cocaine addiction_Homo sapiens_hsa050300.52512644
80Dorso-ventral axis formation_Homo sapiens_hsa043200.52440850
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51366975
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50104347
83Colorectal cancer_Homo sapiens_hsa052100.47564896
84Taste transduction_Homo sapiens_hsa047420.47511444
85Chemical carcinogenesis_Homo sapiens_hsa052040.45768559
86Melanoma_Homo sapiens_hsa052180.43201513
87Hippo signaling pathway_Homo sapiens_hsa043900.42790869
88Ras signaling pathway_Homo sapiens_hsa040140.42000400
89mTOR signaling pathway_Homo sapiens_hsa041500.40505191
90Alcoholism_Homo sapiens_hsa050340.39054242
91Notch signaling pathway_Homo sapiens_hsa043300.38736158
92ABC transporters_Homo sapiens_hsa020100.38371147
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38204271
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36838629
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35012823
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34095510
97Systemic lupus erythematosus_Homo sapiens_hsa053220.34073759
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.32887281
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32267196
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32156029

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