ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.39195731
2	behavioral response to nicotine (GO:0035095)	5.83674286
3	ATP synthesis coupled proton transport (GO:0015986)	5.56809635
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.56809635
5	viral transcription (GO:0019083)	5.56344787
6	ribosomal small subunit assembly (GO:0000028)	5.55739627
7	protein localization to cilium (GO:0061512)	5.44454281
8	translational termination (GO:0006415)	5.28169828
9	heart trabecula morphogenesis (GO:0061384)	4.95590330
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.57278988
11	translational elongation (GO:0006414)	4.56051174
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.39870108
13	cotranslational protein targeting to membrane (GO:0006613)	4.38273492
14	ribosomal small subunit biogenesis (GO:0042274)	4.37020052
15	protein targeting to ER (GO:0045047)	4.32071691
16	ventricular trabecula myocardium morphogenesis (GO:0003222)	4.25798880
17	sequestering of actin monomers (GO:0042989)	4.19687909
18	ribosomal large subunit biogenesis (GO:0042273)	4.13095987
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.12715837
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07910135
21	protein complex biogenesis (GO:0070271)	4.04627727
22	viral life cycle (GO:0019058)	4.02569732
23	cellular protein complex disassembly (GO:0043624)	3.98344180
24	protein localization to endoplasmic reticulum (GO:0070972)	3.94281381
25	neural tube formation (GO:0001841)	3.90746021
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.72288403
27	regulation of penile erection (GO:0060405)	3.69398335
28	cardiac right ventricle morphogenesis (GO:0003215)	3.62471642
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.61988849
30	kidney morphogenesis (GO:0060993)	3.51712286
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.50048819
32	NADH dehydrogenase complex assembly (GO:0010257)	3.50048819
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.50048819
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47897252
35	respiratory electron transport chain (GO:0022904)	3.47449552
36	electron transport chain (GO:0022900)	3.44418239
37	translational initiation (GO:0006413)	3.41712444
38	trabecula morphogenesis (GO:0061383)	3.38293347
39	limb bud formation (GO:0060174)	3.23146798
40	protein complex disassembly (GO:0043241)	3.22688813
41	negative regulation of appetite (GO:0032099)	3.21885715
42	negative regulation of response to food (GO:0032096)	3.21885715
43	chaperone-mediated protein transport (GO:0072321)	3.16081413
44	regulation of action potential (GO:0098900)	3.13859817
45	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.11132718
46	negative regulation of mast cell activation (GO:0033004)	3.07669805
47	tryptophan catabolic process (GO:0006569)	3.05009755
48	indole-containing compound catabolic process (GO:0042436)	3.05009755
49	indolalkylamine catabolic process (GO:0046218)	3.05009755
50	blood vessel maturation (GO:0001955)	3.02062135
51	serotonin receptor signaling pathway (GO:0007210)	3.01781726
52	macromolecular complex disassembly (GO:0032984)	3.00868794
53	sulfation (GO:0051923)	2.96289659
54	regulation of appetite (GO:0032098)	2.94838983
55	positive regulation of Notch signaling pathway (GO:0045747)	2.91716086
56	mannosylation (GO:0097502)	2.89398587
57	maturation of SSU-rRNA (GO:0030490)	2.89148759
58	DNA deamination (GO:0045006)	2.87015205
59	GPI anchor metabolic process (GO:0006505)	2.85967382
60	regulation of dopamine secretion (GO:0014059)	2.84830719
61	drinking behavior (GO:0042756)	2.83448457
62	ATP biosynthetic process (GO:0006754)	2.83447527
63	Notch signaling involved in heart development (GO:0061314)	2.81147191
64	cornea development in camera-type eye (GO:0061303)	2.78230179
65	transcytosis (GO:0045056)	2.76848623
66	indolalkylamine metabolic process (GO:0006586)	2.75911927
67	neuron fate specification (GO:0048665)	2.75130930
68	cellular ketone body metabolic process (GO:0046950)	2.68096830
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65521184
70	protein neddylation (GO:0045116)	2.64536569
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.63882511
72	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.61752055
73	hydrogen ion transmembrane transport (GO:1902600)	2.60659268
74	ketone body metabolic process (GO:1902224)	2.58229106
75	DNA damage response, detection of DNA damage (GO:0042769)	2.57673810
76	kynurenine metabolic process (GO:0070189)	2.55419908
77	neuron fate determination (GO:0048664)	2.54981586
78	mRNA catabolic process (GO:0006402)	2.54532057
79	protein targeting to membrane (GO:0006612)	2.54227871
80	regulation of feeding behavior (GO:0060259)	2.53356677
81	positive regulation of mRNA processing (GO:0050685)	2.51933510
82	positive regulation of meiosis (GO:0045836)	2.51407916
83	negative regulation of inclusion body assembly (GO:0090084)	2.50962495
84	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.50393429
85	short-term memory (GO:0007614)	2.49596047
86	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.48980401
87	translation (GO:0006412)	2.48068461
88	activated T cell proliferation (GO:0050798)	2.46951942
89	ncRNA 3-end processing (GO:0043628)	2.45400500
90	GPI anchor biosynthetic process (GO:0006506)	2.45158810
91	platelet dense granule organization (GO:0060155)	2.44493364
92	adult feeding behavior (GO:0008343)	2.42730602
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40010205
94	RNA destabilization (GO:0050779)	2.39305226
95	proton transport (GO:0015992)	2.37459787
96	tryptophan metabolic process (GO:0006568)	2.36809133
97	cellular component biogenesis (GO:0044085)	2.36399063
98	hydrogen transport (GO:0006818)	2.35980843
99	positive regulation of meiotic cell cycle (GO:0051446)	2.35743431
100	presynaptic membrane organization (GO:0097090)	2.34216379

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.88379327
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23336440
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.02085274
4	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.66045634
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56916539
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.41325645
7	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.39380592
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27399373
9	RNF2_27304074_Chip-Seq_NSC_Mouse	2.25901221
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24762473
11	FUS_26573619_Chip-Seq_HEK293_Human	2.19075355
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.11701439
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.11245848
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10679113
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.08341677
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03287876
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02685428
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.97534768
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96743682
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89823311
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.89297376
22	P300_19829295_ChIP-Seq_ESCs_Human	1.88312422
23	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.87877987
24	EWS_26573619_Chip-Seq_HEK293_Human	1.85991478
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82765986
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.82083531
27	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.75016383
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.74836214
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.74827772
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.72372635
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.72325865
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68761272
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.67726285
34	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.67542364
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61882899
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.60328233
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57644836
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55629172
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.55629172
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54555842
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.53562959
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53232988
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53232988
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49350170
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49350170
46	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.48458985
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46469230
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45709854
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45653791
50	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45396442
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43235760
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43188242
53	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.41616779
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.41583165
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.40903174
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.39745271
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.39222529
58	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.37434373
59	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.37434373
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35846467
61	AR_25329375_ChIP-Seq_VCAP_Human	1.34300080
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33763457
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33763457
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.27719398
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27487047
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25534577
67	HTT_18923047_ChIP-ChIP_STHdh_Human	1.24879201
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24479697
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23014303
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22685929
71	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.20311707
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19180418
73	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.17566943
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17191843
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16749470
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15761881
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13578212
78	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.12997899
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12026215
80	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10900810
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09417461
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09333999
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.07898809
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07874463
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07540033
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05765573
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.05522195
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04533866
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.04287167
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02588115
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02289815
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02136745
93	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01623601
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01605680
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00182773
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97581026
97	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97431498
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97202900
99	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95866827
100	NCOR_22424771_ChIP-Seq_293T_Human	0.95341457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.61811558
2	MP0003880_abnormal_central_pattern	3.88587214
3	MP0003136_yellow_coat_color	3.32907532
4	MP0002822_catalepsy	3.09017638
5	MP0005084_abnormal_gallbladder_morpholo	2.89887404
6	MP0002928_abnormal_bile_duct	2.27569284
7	MP0005551_abnormal_eye_electrophysiolog	2.16312921
8	MP0004885_abnormal_endolymph	2.13926634
9	MP0001968_abnormal_touch/_nociception	2.04972632
10	MP0002938_white_spotting	1.98281299
11	MP0000516_abnormal_urinary_system	1.93017050
12	MP0005367_renal/urinary_system_phenotyp	1.93017050
13	MP0001984_abnormal_olfaction	1.91255764
14	MP0005171_absent_coat_pigmentation	1.88261355
15	MP0005174_abnormal_tail_pigmentation	1.80288578
16	MP0001879_abnormal_lymphatic_vessel	1.78740715
17	MP0006276_abnormal_autonomic_nervous	1.77234650
18	MP0004145_abnormal_muscle_electrophysio	1.68462575
19	MP0005646_abnormal_pituitary_gland	1.65497683
20	MP0006292_abnormal_olfactory_placode	1.64383185
21	MP0005167_abnormal_blood-brain_barrier	1.64355132
22	MP0002272_abnormal_nervous_system	1.61112651
23	MP0003718_maternal_effect	1.57644740
24	MP0008875_abnormal_xenobiotic_pharmacok	1.57071035
25	MP0005423_abnormal_somatic_nervous	1.54171937
26	MP0004142_abnormal_muscle_tone	1.53523465
27	MP0002653_abnormal_ependyma_morphology	1.51460433
28	MP0002735_abnormal_chemical_nociception	1.50887943
29	MP0009745_abnormal_behavioral_response	1.50334198
30	MP0003283_abnormal_digestive_organ	1.49721103
31	MP0000631_abnormal_neuroendocrine_gland	1.48896662
32	MP0003011_delayed_dark_adaptation	1.48178813
33	MP0000372_irregular_coat_pigmentation	1.44259218
34	MP0001905_abnormal_dopamine_level	1.42994230
35	MP0002734_abnormal_mechanical_nocicepti	1.41392964
36	MP0002736_abnormal_nociception_after	1.39567666
37	MP0006072_abnormal_retinal_apoptosis	1.38631896
38	MP0002572_abnormal_emotion/affect_behav	1.36972396
39	MP0002064_seizures	1.35907281
40	MP0008872_abnormal_physiological_respon	1.35525468
41	MP0005253_abnormal_eye_physiology	1.35360528
42	MP0001529_abnormal_vocalization	1.35127496
43	MP0004742_abnormal_vestibular_system	1.34268565
44	MP0005187_abnormal_penis_morphology	1.32337191
45	MP0002837_dystrophic_cardiac_calcinosis	1.31921217
46	MP0002095_abnormal_skin_pigmentation	1.27214493
47	MP0002638_abnormal_pupillary_reflex	1.25518748
48	MP0001501_abnormal_sleep_pattern	1.22252099
49	MP0002751_abnormal_autonomic_nervous	1.21410646
50	MP0002282_abnormal_trachea_morphology	1.21345170
51	MP0001970_abnormal_pain_threshold	1.21120003
52	MP0002102_abnormal_ear_morphology	1.17426971
53	MP0000026_abnormal_inner_ear	1.17039470
54	MP0004133_heterotaxia	1.16922130
55	MP0003567_abnormal_fetal_cardiomyocyte	1.16545519
56	MP0003315_abnormal_perineum_morphology	1.15070395
57	MP0003638_abnormal_response/metabolism_	1.13566211
58	MP0009785_altered_susceptibility_to	1.13237794
59	MP0002557_abnormal_social/conspecific_i	1.11770892
60	MP0005645_abnormal_hypothalamus_physiol	1.11349285
61	MP0002138_abnormal_hepatobiliary_system	1.08478566
62	MP0000778_abnormal_nervous_system	1.06442995
63	MP0005360_urolithiasis	1.05996032
64	MP0003943_abnormal_hepatobiliary_system	1.04569147
65	MP0001324_abnormal_eye_pigmentation	1.03914560
66	MP0008877_abnormal_DNA_methylation	1.00513609
67	MP0001485_abnormal_pinna_reflex	0.99590330
68	MP0001440_abnormal_grooming_behavior	0.95000100
69	MP0001664_abnormal_digestion	0.94975389
70	MP0010386_abnormal_urinary_bladder	0.93653652
71	MP0005075_abnormal_melanosome_morpholog	0.92832266
72	MP0005083_abnormal_biliary_tract	0.92685446
73	MP0003635_abnormal_synaptic_transmissio	0.91989212
74	MP0002184_abnormal_innervation	0.91210838
75	MP0008995_early_reproductive_senescence	0.90900830
76	MP0002733_abnormal_thermal_nociception	0.89763113
77	MP0001873_stomach_inflammation	0.88306525
78	MP0002752_abnormal_somatic_nervous	0.86788522
79	MP0004147_increased_porphyrin_level	0.86534500
80	MP0001486_abnormal_startle_reflex	0.85554310
81	MP0000383_abnormal_hair_follicle	0.85032067
82	MP0001963_abnormal_hearing_physiology	0.83970590
83	MP0002067_abnormal_sensory_capabilities	0.83836065
84	MP0004510_myositis	0.83493440
85	MP0002277_abnormal_respiratory_mucosa	0.82768506
86	MP0005671_abnormal_response_to	0.80960604
87	MP0003195_calcinosis	0.80209693
88	MP0001188_hyperpigmentation	0.80058827
89	MP0005195_abnormal_posterior_eye	0.79915696
90	MP0002127_abnormal_cardiovascular_syste	0.75949748
91	MP0009764_decreased_sensitivity_to	0.74837298
92	MP0004043_abnormal_pH_regulation	0.74189937
93	MP0000647_abnormal_sebaceous_gland	0.71773767
94	MP0003186_abnormal_redox_activity	0.70351545
95	MP0004085_abnormal_heartbeat	0.70220400
96	MP0003252_abnormal_bile_duct	0.68886345
97	MP0002063_abnormal_learning/memory/cond	0.67158957
98	MP0000955_abnormal_spinal_cord	0.63226060
99	MP0005085_abnormal_gallbladder_physiolo	0.62962364
100	MP0005377_hearing/vestibular/ear_phenot	0.61504237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.62896629
2	Abnormal number of erythroid precursors (HP:0012131)	4.06344110
3	3-Methylglutaconic aciduria (HP:0003535)	3.74662518
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.71804338
5	Renal Fanconi syndrome (HP:0001994)	3.70435144
6	Focal motor seizures (HP:0011153)	3.47785667
7	Optic disc pallor (HP:0000543)	3.35420882
8	Abnormality of midbrain morphology (HP:0002418)	3.35332153
9	Molar tooth sign on MRI (HP:0002419)	3.35332153
10	Nephronophthisis (HP:0000090)	3.33897050
11	Congenital stationary night blindness (HP:0007642)	3.27455458
12	Acute necrotizing encephalopathy (HP:0006965)	3.26582025
13	Hemiparesis (HP:0001269)	3.25438909
14	Generalized aminoaciduria (HP:0002909)	3.24835709
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18787080
16	Mitochondrial inheritance (HP:0001427)	3.14210183
17	Confusion (HP:0001289)	3.02292801
18	Pancreatic cysts (HP:0001737)	2.97362236
19	Abnormal drinking behavior (HP:0030082)	2.94711182
20	Polydipsia (HP:0001959)	2.94711182
21	Concave nail (HP:0001598)	2.84185048
22	Attenuation of retinal blood vessels (HP:0007843)	2.82401499
23	Limb dystonia (HP:0002451)	2.80989826
24	Increased CSF lactate (HP:0002490)	2.76374225
25	Acute encephalopathy (HP:0006846)	2.70813778
26	Diplopia (HP:0000651)	2.70466683
27	Abnormality of binocular vision (HP:0011514)	2.70466683
28	Increased hepatocellular lipid droplets (HP:0006565)	2.69460913
29	Hepatocellular necrosis (HP:0001404)	2.66656643
30	Progressive macrocephaly (HP:0004481)	2.66276055
31	Abnormality of the renal medulla (HP:0100957)	2.62058389
32	Pancreatic fibrosis (HP:0100732)	2.54446156
33	True hermaphroditism (HP:0010459)	2.52855495
34	Constricted visual fields (HP:0001133)	2.48367231
35	Macrocytic anemia (HP:0001972)	2.47232365
36	Abnormality of the renal cortex (HP:0011035)	2.46810791
37	Hepatic necrosis (HP:0002605)	2.44427786
38	Abnormality of macular pigmentation (HP:0008002)	2.42974132
39	Abolished electroretinogram (ERG) (HP:0000550)	2.42437043
40	Lipid accumulation in hepatocytes (HP:0006561)	2.42393149
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.40020520
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.40020520
43	Reticulocytopenia (HP:0001896)	2.37397045
44	Aplastic anemia (HP:0001915)	2.36482947
45	Abnormality of renal resorption (HP:0011038)	2.31659246
46	Methylmalonic acidemia (HP:0002912)	2.24167745
47	Oligodactyly (hands) (HP:0001180)	2.24042324
48	Short tibia (HP:0005736)	2.23404151
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20944821
50	Medial flaring of the eyebrow (HP:0010747)	2.17710005
51	Renal cortical cysts (HP:0000803)	2.15434677
52	Increased intramyocellular lipid droplets (HP:0012240)	2.14971558
53	Focal seizures (HP:0007359)	2.14462305
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13182885
55	Tubular atrophy (HP:0000092)	2.12595548
56	Hyperglycinemia (HP:0002154)	2.10630467
57	Pallor (HP:0000980)	2.09503316
58	Abnormality of urine glucose concentration (HP:0011016)	2.09138349
59	Glycosuria (HP:0003076)	2.09138349
60	Hypothermia (HP:0002045)	2.08942791
61	Abnormality of the labia minora (HP:0012880)	2.08647465
62	B lymphocytopenia (HP:0010976)	2.05343656
63	Polyuria (HP:0000103)	2.04616906
64	Type II lissencephaly (HP:0007260)	2.03814360
65	Retinal dysplasia (HP:0007973)	2.02647988
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00305058
67	Volvulus (HP:0002580)	1.96947709
68	Abnormality of B cell number (HP:0010975)	1.95078287
69	Large for gestational age (HP:0001520)	1.94495814
70	Stenosis of the external auditory canal (HP:0000402)	1.91462716
71	Congenital hepatic fibrosis (HP:0002612)	1.90073480
72	Abnormal pupillary function (HP:0007686)	1.85275678
73	Inability to walk (HP:0002540)	1.85198696
74	Delayed CNS myelination (HP:0002188)	1.84660077
75	Increased serum lactate (HP:0002151)	1.83412748
76	Exertional dyspnea (HP:0002875)	1.82175721
77	Sclerocornea (HP:0000647)	1.80088830
78	Hyperventilation (HP:0002883)	1.79777239
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79091650
80	Prominent supraorbital ridges (HP:0000336)	1.78199629
81	Pendular nystagmus (HP:0012043)	1.77591995
82	Striae distensae (HP:0001065)	1.75476475
83	Abnormality of alanine metabolism (HP:0010916)	1.74775028
84	Hyperalaninemia (HP:0003348)	1.74775028
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74775028
86	Cerebral edema (HP:0002181)	1.72892559
87	Leukodystrophy (HP:0002415)	1.72536606
88	Dyskinesia (HP:0100660)	1.71267522
89	Male pseudohermaphroditism (HP:0000037)	1.71131478
90	Hyperphosphaturia (HP:0003109)	1.69771802
91	Abnormal urine output (HP:0012590)	1.69096797
92	Increased muscle lipid content (HP:0009058)	1.68859948
93	Failure to thrive in infancy (HP:0001531)	1.68000190
94	Decreased central vision (HP:0007663)	1.67217746
95	Lethargy (HP:0001254)	1.64676370
96	Esophageal atresia (HP:0002032)	1.63188930
97	Severe combined immunodeficiency (HP:0004430)	1.61940480
98	Panhypogammaglobulinemia (HP:0003139)	1.61206564
99	Partial agenesis of the corpus callosum (HP:0001338)	1.59941042
100	Woolly hair (HP:0002224)	1.58221480

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	3.71764669
2	FLT3	3.44437912
3	SIK2	3.42586090
4	MAPK15	3.32322673
5	TAOK3	3.32301805
6	KIT	2.90636755
7	EPHB2	2.53650916
8	PNCK	2.53043681
9	CDK19	2.34527902
10	PINK1	2.21265293
11	INSRR	2.07886870
12	TIE1	1.87185456
13	BCKDK	1.82459875
14	MAP4K2	1.78793109
15	TEC	1.77893037
16	ADRBK2	1.77338831
17	DYRK2	1.76834032
18	WNK3	1.72894987
19	GRK1	1.69864461
20	MAPK13	1.60261850
21	BMPR1B	1.55547874
22	WEE1	1.54725063
23	VRK1	1.49609020
24	ZAK	1.48604102
25	DYRK3	1.47377239
26	BUB1	1.47001729
27	TLK1	1.45355814
28	TXK	1.39628361
29	CDK3	1.34798465
30	FES	1.33304117
31	TGFBR1	1.23543680
32	EPHA4	1.17900067
33	OXSR1	1.11412407
34	VRK2	1.10865299
35	MAP3K12	1.08658285
36	PBK	1.03615536
37	MAP4K1	1.03404439
38	FRK	1.02298852
39	TAF1	0.95773881
40	PRKG2	0.93778559
41	PKN2	0.93484945
42	PRKCG	0.88910278
43	CDK8	0.88565355
44	ADRBK1	0.86657335
45	ACVR1B	0.81758806
46	NME1	0.75670193
47	RPS6KA5	0.74627254
48	SYK	0.74414607
49	MINK1	0.73488313
50	IRAK1	0.73334260
51	MARK1	0.73231575
52	PASK	0.70422028
53	WNK4	0.70385528
54	PRKCQ	0.69787855
55	IKBKE	0.67148055
56	OBSCN	0.65255851
57	IKBKB	0.64347224
58	NEK1	0.61015209
59	CASK	0.59776140
60	STK39	0.58969122
61	NEK2	0.58315033
62	CAMK2A	0.56299949
63	TNIK	0.55475769
64	MAP2K6	0.54283708
65	MATK	0.53837613
66	ITK	0.53114499
67	CSF1R	0.50647362
68	PRKACA	0.50608516
69	CAMK2D	0.49602047
70	DYRK1B	0.48679525
71	MAP3K4	0.47824269
72	DYRK1A	0.46998257
73	IRAK2	0.46480964
74	DAPK2	0.46052328
75	CAMK2B	0.45519793
76	PLK4	0.44227664
77	PRKG1	0.43920896
78	PKN1	0.43900129
79	NUAK1	0.43882242
80	ERBB3	0.42527245
81	MAPKAPK5	0.40590327
82	UHMK1	0.40419676
83	CAMKK2	0.38466431
84	PRKCE	0.37723555
85	CSNK2A2	0.37249078
86	CAMK1	0.37186633
87	PIK3CG	0.37011467
88	TYRO3	0.35557623
89	PRKCA	0.34986349
90	CSNK2A1	0.34618173
91	STK16	0.34582079
92	MAP2K7	0.34274398
93	PIK3CA	0.33403768
94	LYN	0.33145772
95	MAP3K11	0.30746172
96	PLK3	0.30271387
97	TNK2	0.29414055
98	RPS6KA6	0.28772661
99	EPHA3	0.26027877
100	LCK	0.25680826

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.76406511
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20992130
3	Parkinsons disease_Homo sapiens_hsa05012	3.50524456
4	Nicotine addiction_Homo sapiens_hsa05033	2.91520629
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76189963
6	Alzheimers disease_Homo sapiens_hsa05010	2.56127041
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30081666
8	Protein export_Homo sapiens_hsa03060	2.17855391
9	Huntingtons disease_Homo sapiens_hsa05016	2.14391566
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.11376016
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.04704416
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.98675985
13	Phototransduction_Homo sapiens_hsa04744	1.97259860
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.91270138
15	Asthma_Homo sapiens_hsa05310	1.89362024
16	Caffeine metabolism_Homo sapiens_hsa00232	1.72833273
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71561127
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68897169
19	Olfactory transduction_Homo sapiens_hsa04740	1.68702253
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.60323068
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.49469002
22	Cocaine addiction_Homo sapiens_hsa05030	1.44851883
23	Proteasome_Homo sapiens_hsa03050	1.37109887
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36779124
25	Butanoate metabolism_Homo sapiens_hsa00650	1.33110931
26	Taste transduction_Homo sapiens_hsa04742	1.30023581
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28469795
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.23777914
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.20761538
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20189140
31	One carbon pool by folate_Homo sapiens_hsa00670	1.19781808
32	Allograft rejection_Homo sapiens_hsa05330	1.19110767
33	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.13602545
34	RNA polymerase_Homo sapiens_hsa03020	1.07852494
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07193570
36	Basal transcription factors_Homo sapiens_hsa03022	1.05255138
37	Antigen processing and presentation_Homo sapiens_hsa04612	1.04337149
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04313394
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00660426
40	RNA degradation_Homo sapiens_hsa03018	0.92511732
41	Graft-versus-host disease_Homo sapiens_hsa05332	0.91718238
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.89924557
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89775172
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89770177
45	Type I diabetes mellitus_Homo sapiens_hsa04940	0.89327629
46	Amphetamine addiction_Homo sapiens_hsa05031	0.88470901
47	Serotonergic synapse_Homo sapiens_hsa04726	0.86334587
48	African trypanosomiasis_Homo sapiens_hsa05143	0.84659882
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84413720
50	Morphine addiction_Homo sapiens_hsa05032	0.82038607
51	Retinol metabolism_Homo sapiens_hsa00830	0.81894936
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81285537
53	Histidine metabolism_Homo sapiens_hsa00340	0.79976416
54	Circadian entrainment_Homo sapiens_hsa04713	0.78194683
55	GABAergic synapse_Homo sapiens_hsa04727	0.77672619
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76906768
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76297312
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73098190
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.69428665
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65734424
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65506084
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64810280
63	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63968073
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.63483341
65	Salivary secretion_Homo sapiens_hsa04970	0.62437401
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61940531
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60440450
68	Homologous recombination_Homo sapiens_hsa03440	0.58814150
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57911957
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56165476
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.55344742
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54440869
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.54369874
74	Metabolic pathways_Homo sapiens_hsa01100	0.54273418
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.51952181
76	Glutathione metabolism_Homo sapiens_hsa00480	0.51362412
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49884312
78	Insulin secretion_Homo sapiens_hsa04911	0.49264400
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48845355
80	Purine metabolism_Homo sapiens_hsa00230	0.45660193
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45008694
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.42402602
83	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41802639
84	Peroxisome_Homo sapiens_hsa04146	0.40482708
85	Renin secretion_Homo sapiens_hsa04924	0.39793919
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39155615
87	Propanoate metabolism_Homo sapiens_hsa00640	0.38778725
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34721262
89	Spliceosome_Homo sapiens_hsa03040	0.34160544
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33200909
91	Long-term depression_Homo sapiens_hsa04730	0.33079235
92	Legionellosis_Homo sapiens_hsa05134	0.32611406
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29512561
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26176315
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25952478
96	Mineral absorption_Homo sapiens_hsa04978	0.25661369
97	Sulfur relay system_Homo sapiens_hsa04122	0.25082852
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.25082133
99	Cholinergic synapse_Homo sapiens_hsa04725	0.24744284
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.23533348

RPSAP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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