RPSAP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)7.58203931
2maturation of SSU-rRNA (GO:0030490)6.98997065
3viral transcription (GO:0019083)6.98994908
4ribosomal small subunit biogenesis (GO:0042274)6.63223315
5translational termination (GO:0006415)6.44200991
6negative regulation of muscle hypertrophy (GO:0014741)6.34769710
7striated muscle atrophy (GO:0014891)6.12785470
8skeletal muscle adaptation (GO:0043501)5.96005257
9ribosomal small subunit assembly (GO:0000028)5.93619499
10translational elongation (GO:0006414)5.81483362
11muscle atrophy (GO:0014889)5.78375066
12regulation of skeletal muscle contraction (GO:0014819)5.76328350
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.32175104
14protein targeting to ER (GO:0045047)5.25171185
15cotranslational protein targeting to membrane (GO:0006613)5.23831752
16skeletal muscle tissue regeneration (GO:0043403)5.09001461
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.00809744
18response to muscle activity (GO:0014850)5.00143977
19cellular protein complex disassembly (GO:0043624)4.97806586
20viral life cycle (GO:0019058)4.94800930
21protein localization to endoplasmic reticulum (GO:0070972)4.94048934
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.90074871
23actin-myosin filament sliding (GO:0033275)4.84626295
24muscle filament sliding (GO:0030049)4.84626295
25protein complex disassembly (GO:0043241)4.47609796
26translational initiation (GO:0006413)4.45720475
27cell proliferation in forebrain (GO:0021846)4.37106474
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.32540232
29macromolecular complex disassembly (GO:0032984)4.17959388
30behavioral response to nicotine (GO:0035095)4.17886836
31chaperone-mediated protein transport (GO:0072321)4.13981662
32actin-mediated cell contraction (GO:0070252)3.86888922
33DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.81391857
34negative regulation of skeletal muscle tissue development (GO:0048642)3.80353144
35embryonic skeletal joint morphogenesis (GO:0060272)3.74786443
36protein K6-linked ubiquitination (GO:0085020)3.69869249
37ATP synthesis coupled proton transport (GO:0015986)3.64989941
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64989941
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.59631822
40NADH dehydrogenase complex assembly (GO:0010257)3.59631822
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59631822
42translation (GO:0006412)3.58962440
43DNA damage response, signal transduction resulting in transcription (GO:0042772)3.55595160
44cellular response to dexamethasone stimulus (GO:0071549)3.54820336
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52936835
46protein polyglutamylation (GO:0018095)3.52826154
47protein complex biogenesis (GO:0070271)3.51488712
48cullin deneddylation (GO:0010388)3.50774432
49substrate-independent telencephalic tangential migration (GO:0021826)3.48693866
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.48693866
51protein targeting to membrane (GO:0006612)3.48273084
52nuclear-transcribed mRNA catabolic process (GO:0000956)3.36659461
53pattern specification involved in kidney development (GO:0061004)3.30737935
54protein neddylation (GO:0045116)3.25386098
55response to dexamethasone (GO:0071548)3.20670317
56negative regulation of organelle assembly (GO:1902116)3.19570494
57mRNA catabolic process (GO:0006402)3.16908274
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.15789447
59response to electrical stimulus (GO:0051602)3.14396843
60response to activity (GO:0014823)3.12623868
61ribonucleoprotein complex biogenesis (GO:0022613)3.12592133
62mitochondrial respiratory chain complex assembly (GO:0033108)3.10225532
63regulation of DNA methylation (GO:0044030)3.09137473
64genetic imprinting (GO:0071514)3.05554154
65cellular component biogenesis (GO:0044085)3.02835450
66protein deneddylation (GO:0000338)2.99672212
67mesonephros development (GO:0001823)2.99334260
68ganglion development (GO:0061548)2.97815295
69organ induction (GO:0001759)2.94915664
70dendritic spine morphogenesis (GO:0060997)2.91747166
71RNA catabolic process (GO:0006401)2.87025294
72ovulation cycle (GO:0042698)2.87021468
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83260026
74electron transport chain (GO:0022900)2.82949016
75respiratory electron transport chain (GO:0022904)2.81573509
76lung secretory cell differentiation (GO:0061140)2.80332549
77outer ear morphogenesis (GO:0042473)2.78415377
78regulation of gene expression by genetic imprinting (GO:0006349)2.71109271
79neurofilament cytoskeleton organization (GO:0060052)2.69240917
80transmission of nerve impulse (GO:0019226)2.68153908
81middle ear morphogenesis (GO:0042474)2.68118324
82cardiovascular system development (GO:0072358)2.65792330
83rRNA processing (GO:0006364)2.65496485
84ribosomal large subunit biogenesis (GO:0042273)2.63492373
85auditory behavior (GO:0031223)2.58220500
86positive regulation of T cell apoptotic process (GO:0070234)2.58162214
87glandular epithelial cell differentiation (GO:0002067)2.58110107
88GTP biosynthetic process (GO:0006183)2.57816296
89protein-cofactor linkage (GO:0018065)2.56871064
90rRNA metabolic process (GO:0016072)2.54481567
91response to testosterone (GO:0033574)2.53825789
92regulation of mitochondrial translation (GO:0070129)2.52314942
93developmental induction (GO:0031128)2.52154439
94thyroid gland development (GO:0030878)2.51034667
95positive regulation by host of viral transcription (GO:0043923)2.49304317
96negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.49061954
97protein trimerization (GO:0070206)2.48789718
98embryonic hindlimb morphogenesis (GO:0035116)2.48774634
99cell-cell signaling involved in cell fate commitment (GO:0045168)2.48487583
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.46318635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99304799
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36168857
3VDR_22108803_ChIP-Seq_LS180_Human3.98770650
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96701841
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.83045278
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.64844076
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.80233797
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.43030486
9TP53_20018659_ChIP-ChIP_R1E_Mouse2.16615430
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13737210
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.13056231
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.12249475
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.11625317
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11420392
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09677990
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03347189
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.02956900
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00841383
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99391503
20XRN2_22483619_ChIP-Seq_HELA_Human1.98351494
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91800477
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.91028495
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.88353258
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80555347
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77562905
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75465205
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71102577
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69888413
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69888413
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.64812711
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57086791
32KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55455747
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53534032
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51977176
35TTF2_22483619_ChIP-Seq_HELA_Human1.51669380
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.51484523
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50987476
38IRF1_19129219_ChIP-ChIP_H3396_Human1.49470525
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.48904574
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.46874886
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46031142
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43299071
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42162821
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.38829475
45REST_21632747_ChIP-Seq_MESCs_Mouse1.38710116
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37367651
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33060318
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.32284521
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.31851213
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29418622
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26752546
52FOXP1_21924763_ChIP-Seq_HESCs_Human1.26401204
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22735483
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21566551
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20034772
56FUS_26573619_Chip-Seq_HEK293_Human1.18778135
57TP53_22573176_ChIP-Seq_HFKS_Human1.17753265
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.16182372
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15820493
60GABP_19822575_ChIP-Seq_HepG2_Human1.14764197
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12820540
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11877800
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11362675
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.10779810
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10423936
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09708493
67CTCF_27219007_Chip-Seq_Bcells_Human1.09493798
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07298582
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07006669
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06830066
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05786952
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.04939902
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04912752
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.03436487
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03259830
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02511602
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00929061
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00296669
79P68_20966046_ChIP-Seq_HELA_Human0.99577708
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98834028
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98834028
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98834028
83MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97267800
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97096390
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96860996
86TAF15_26573619_Chip-Seq_HEK293_Human0.95912032
87MYC_18940864_ChIP-ChIP_HL60_Human0.95448200
88ERA_21632823_ChIP-Seq_H3396_Human0.94590991
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94429357
90TAF2_19829295_ChIP-Seq_ESCs_Human0.91233272
91MYC_19829295_ChIP-Seq_ESCs_Human0.90852011
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90133263
93LXR_22292898_ChIP-Seq_THP-1_Human0.89978883
94TP53_22127205_ChIP-Seq_IMR90_Human0.89536122
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89014407
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88799144
97E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88777016
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88260632
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87656782
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87185297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.75863593
2MP0003123_paternal_imprinting3.46823119
3MP0004145_abnormal_muscle_electrophysio2.85159224
4MP0003646_muscle_fatigue2.73075277
5MP0003787_abnormal_imprinting2.62409107
6MP0006292_abnormal_olfactory_placode2.53795825
7MP0000747_muscle_weakness2.36989670
8MP0005646_abnormal_pituitary_gland2.28755944
9MP0002089_abnormal_postnatal_growth/wei2.28315503
10MP0002822_catalepsy2.21816796
11MP0000049_abnormal_middle_ear2.12032885
12MP0008789_abnormal_olfactory_epithelium2.10703434
13MP0001968_abnormal_touch/_nociception2.04130331
14MP0005083_abnormal_biliary_tract2.02893877
15MP0000678_abnormal_parathyroid_gland1.96550615
16MP0001485_abnormal_pinna_reflex1.89393240
17MP0004142_abnormal_muscle_tone1.80812524
18MP0002736_abnormal_nociception_after1.80015414
19MP0002277_abnormal_respiratory_mucosa1.76157638
20MP0010030_abnormal_orbit_morphology1.75822019
21MP0000749_muscle_degeneration1.68617570
22MP0009250_abnormal_appendicular_skeleto1.67353379
23MP0004036_abnormal_muscle_relaxation1.66413880
24MP0000566_synostosis1.61983965
25MP0000759_abnormal_skeletal_muscle1.59733608
26MP0002269_muscular_atrophy1.57312820
27MP0002837_dystrophic_cardiac_calcinosis1.54288123
28MP0006072_abnormal_retinal_apoptosis1.52534227
29MP0003937_abnormal_limbs/digits/tail_de1.51828154
30MP0003942_abnormal_urinary_system1.50836354
31MP0000778_abnormal_nervous_system1.48540771
32MP0002160_abnormal_reproductive_system1.47742104
33MP0003315_abnormal_perineum_morphology1.45038135
34MP0004133_heterotaxia1.43985301
35MP0005394_taste/olfaction_phenotype1.43150204
36MP0005499_abnormal_olfactory_system1.43150204
37MP0004885_abnormal_endolymph1.40791455
38MP0003938_abnormal_ear_development1.40395375
39MP0003121_genomic_imprinting1.38417667
40MP0002108_abnormal_muscle_morphology1.35955629
41MP0002653_abnormal_ependyma_morphology1.34505307
42MP0003878_abnormal_ear_physiology1.30957356
43MP0005377_hearing/vestibular/ear_phenot1.30957356
44MP0009745_abnormal_behavioral_response1.27357568
45MP0004270_analgesia1.27010484
46MP0001529_abnormal_vocalization1.26718689
47MP0001502_abnormal_circadian_rhythm1.26020518
48MP0001905_abnormal_dopamine_level1.25636584
49MP0003122_maternal_imprinting1.25196341
50MP0005423_abnormal_somatic_nervous1.24554986
51MP0002095_abnormal_skin_pigmentation1.24448500
52MP0003705_abnormal_hypodermis_morpholog1.23961521
53MP0000631_abnormal_neuroendocrine_gland1.22519822
54MP0002272_abnormal_nervous_system1.21887765
55MP0002184_abnormal_innervation1.21705424
56MP0009053_abnormal_anal_canal1.21195318
57MP0004043_abnormal_pH_regulation1.18269412
58MP0006276_abnormal_autonomic_nervous1.17735894
59MP0002138_abnormal_hepatobiliary_system1.17386352
60MP0000537_abnormal_urethra_morphology1.17139994
61MP0002638_abnormal_pupillary_reflex1.17099990
62MP0003959_abnormal_lean_body1.15351337
63MP0002106_abnormal_muscle_physiology1.09021067
64MP0005620_abnormal_muscle_contractility1.08591835
65MP0002249_abnormal_larynx_morphology1.08552239
66MP0000372_irregular_coat_pigmentation1.07749999
67MP0002876_abnormal_thyroid_physiology1.07432613
68MP0003880_abnormal_central_pattern1.06830379
69MP0001486_abnormal_startle_reflex1.06503788
70MP0005389_reproductive_system_phenotype1.05087409
71MP0002163_abnormal_gland_morphology1.05087392
72MP0001348_abnormal_lacrimal_gland1.05026867
73MP0003755_abnormal_palate_morphology1.02619882
74MP0004742_abnormal_vestibular_system1.01158240
75MP0002734_abnormal_mechanical_nocicepti0.98690220
76MP0000750_abnormal_muscle_regeneration0.97397228
77MP0000955_abnormal_spinal_cord0.97233065
78MP0002733_abnormal_thermal_nociception0.96993385
79MP0000026_abnormal_inner_ear0.96569393
80MP0001440_abnormal_grooming_behavior0.94841980
81MP0001293_anophthalmia0.93454587
82MP0002752_abnormal_somatic_nervous0.93380902
83MP0002557_abnormal_social/conspecific_i0.90769751
84MP0003879_abnormal_hair_cell0.88707055
85MP0005369_muscle_phenotype0.87750353
86MP0002177_abnormal_outer_ear0.87018454
87MP0004087_abnormal_muscle_fiber0.86748854
88MP0004130_abnormal_muscle_cell0.86587542
89MP0003635_abnormal_synaptic_transmissio0.84665846
90MP0000534_abnormal_ureter_morphology0.84032961
91MP0001970_abnormal_pain_threshold0.82382676
92MP0002067_abnormal_sensory_capabilities0.81996821
93MP0001963_abnormal_hearing_physiology0.81721745
94MP0002735_abnormal_chemical_nociception0.80597973
95MP0009780_abnormal_chondrocyte_physiolo0.79719155
96MP0003119_abnormal_digestive_system0.79612080
97MP0002938_white_spotting0.79544365
98MP0002210_abnormal_sex_determination0.79487858
99MP0008775_abnormal_heart_ventricle0.77373293
100MP0000613_abnormal_salivary_gland0.76584660

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)5.34842440
2Reticulocytopenia (HP:0001896)4.38657499
3Abnormality of cells of the erythroid lineage (HP:0012130)3.90419956
4Absent phalangeal crease (HP:0006109)3.65043704
5Stenosis of the external auditory canal (HP:0000402)3.60966994
6Distal arthrogryposis (HP:0005684)3.39348122
7Ulnar deviation of the wrist (HP:0003049)3.35897937
8Calcaneovalgus deformity (HP:0001848)3.33612504
9Mask-like facies (HP:0000298)3.32804400
10Round ear (HP:0100830)3.32580855
11Abnormal number of erythroid precursors (HP:0012131)3.20094942
12Acute necrotizing encephalopathy (HP:0006965)3.18107655
13Down-sloping shoulders (HP:0200021)3.07003612
14Abnormal finger flexion creases (HP:0006143)3.00725715
153-Methylglutaconic aciduria (HP:0003535)2.97210518
16Exercise-induced myalgia (HP:0003738)2.90956976
17Nemaline bodies (HP:0003798)2.90436386
18Hyperkalemia (HP:0002153)2.86028642
19Deformed tarsal bones (HP:0008119)2.85104674
20Mitochondrial inheritance (HP:0001427)2.81334369
21Abnormal mitochondria in muscle tissue (HP:0008316)2.77380510
22Septo-optic dysplasia (HP:0100842)2.75504601
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73632402
24Acute encephalopathy (HP:0006846)2.57761762
25Macrocytic anemia (HP:0001972)2.57316849
26Decreased circulating renin level (HP:0003351)2.55954210
27Pendular nystagmus (HP:0012043)2.54479255
28Progressive macrocephaly (HP:0004481)2.48996803
29Hepatocellular necrosis (HP:0001404)2.48747229
30Adrenal hypoplasia (HP:0000835)2.45177189
31Periorbital edema (HP:0100539)2.44078092
32Increased CSF lactate (HP:0002490)2.42437022
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40236721
34Facial edema (HP:0000282)2.35668473
35Pallor (HP:0000980)2.28883836
36Abnormality of midbrain morphology (HP:0002418)2.28684345
37Molar tooth sign on MRI (HP:0002419)2.28684345
38Symphalangism affecting the phalanges of the hand (HP:0009773)2.27998885
39Severe visual impairment (HP:0001141)2.26856601
40Fibular aplasia (HP:0002990)2.26524033
41Anophthalmia (HP:0000528)2.26499180
42Muscle fiber inclusion bodies (HP:0100299)2.24639044
43Hypoplasia of the radius (HP:0002984)2.23996554
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.22255155
45Asplenia (HP:0001746)2.20543032
46Maternal diabetes (HP:0009800)2.18916215
47Nephronophthisis (HP:0000090)2.18308674
48Myotonia (HP:0002486)2.17666814
49Hepatic necrosis (HP:0002605)2.16937214
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16280084
51Abnormality of the renal collecting system (HP:0004742)2.10082039
52Absent thumb (HP:0009777)2.08465327
53Tubular atrophy (HP:0000092)2.05157666
54Abnormality of the 4th metacarpal (HP:0010012)2.04247946
55Abnormal rod and cone electroretinograms (HP:0008323)2.01975687
56Forearm undergrowth (HP:0009821)2.01961982
57Hyperphosphatemia (HP:0002905)1.99924480
58Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99851582
59Hypoplasia of the ulna (HP:0003022)1.96817563
60Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95925953
61Muscle fiber atrophy (HP:0100295)1.95902968
62Myopathic facies (HP:0002058)1.95847535
63Type 2 muscle fiber atrophy (HP:0003554)1.93514164
64Myokymia (HP:0002411)1.92791933
65Abnormality of DNA repair (HP:0003254)1.92608158
66Pancreatic cysts (HP:0001737)1.91152760
67Abnormality of the renal medulla (HP:0100957)1.90737635
68Nonprogressive disorder (HP:0003680)1.90402422
69Conjunctival hamartoma (HP:0100780)1.87671079
70Broad hallux (HP:0010055)1.86111881
71Patent foramen ovale (HP:0001655)1.85852698
72Bell-shaped thorax (HP:0001591)1.85445179
73Absent septum pellucidum (HP:0001331)1.85352062
74Partial duplication of the phalanx of hand (HP:0009999)1.82114315
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80868435
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80868435
77Microretrognathia (HP:0000308)1.78546234
78Pancreatic fibrosis (HP:0100732)1.78517503
79Short 4th metacarpal (HP:0010044)1.77278011
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77278011
81Enlarged penis (HP:0000040)1.75904422
82Type II lissencephaly (HP:0007260)1.75667368
83Oligodactyly (HP:0012165)1.75286868
84Abolished electroretinogram (ERG) (HP:0000550)1.74018513
85Rib fusion (HP:0000902)1.71975976
86Abnormality of the middle phalanges of the toes (HP:0010183)1.71686254
87Ectopic kidney (HP:0000086)1.70072894
88Abnormality of the phalanges of the 5th finger (HP:0004213)1.69658510
89Increased serum lactate (HP:0002151)1.69424680
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68441160
91Renal dysplasia (HP:0000110)1.68240578
92Optic nerve hypoplasia (HP:0000609)1.68199264
93Mesomelia (HP:0003027)1.67968626
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67394883
95Abnormality of the aortic arch (HP:0012303)1.67378711
96Aplasia/hypoplasia of the uterus (HP:0008684)1.67256139
97Abnormality of magnesium homeostasis (HP:0004921)1.67060968
98Abnormality of potassium homeostasis (HP:0011042)1.64880138
99Aplasia/Hypoplasia of the patella (HP:0006498)1.64475709
100Type 1 muscle fiber predominance (HP:0003803)1.63159711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.78329499
2WNK43.81901697
3PHKG13.24621562
4PHKG23.24621562
5VRK22.99546942
6ARAF2.71534206
7TIE12.61246319
8LIMK12.40797584
9STK162.00451440
10OBSCN1.97952443
11CASK1.92629405
12DYRK21.87738832
13ICK1.83139909
14NUAK11.81830401
15TYRO31.81798540
16TESK21.81235062
17CAMKK11.78160373
18STK391.77096072
19TLK11.76264112
20WNK11.76151738
21CAMK1D1.74265032
22CAMKK21.64025049
23CAMK1G1.63883031
24EPHB21.60989744
25PRKD31.58654238
26BCKDK1.43434232
27PIK3CA1.38020570
28IRAK11.32250310
29MAP3K111.25611261
30AURKA1.17091202
31PIM21.16830832
32PDK21.16193435
33TAF11.16095752
34BRAF1.14193772
35TESK11.10720253
36LRRK21.06301991
37STK111.00373416
38MAP3K90.99844893
39CAMK10.96665521
40PASK0.96472336
41MAPK130.96157328
42MUSK0.92938651
43MOS0.90118056
44CAMK2G0.84916256
45MAP2K70.83549517
46BUB10.82983156
47CHEK20.79838192
48INSRR0.78308468
49ABL20.78096677
50CDK190.75649199
51ADRBK20.74387415
52SIK20.73745849
53LMTK20.72966173
54DYRK1B0.72946830
55CCNB10.71393823
56RPS6KA50.70541702
57MARK20.67323543
58NEK20.66096635
59CSNK1G20.65656648
60ILK0.65084113
61SRPK10.65062142
62MAP4K20.64881822
63GRK10.64770514
64PINK10.64022771
65PRKCG0.63894765
66RPS6KA20.63332263
67SGK4940.62689478
68SGK2230.62689478
69MINK10.62443217
70MAPKAPK30.62227920
71EPHA40.61856483
72RPS6KA60.61390787
73WNK30.60805437
74PTK60.55217351
75CAMK40.53624271
76NTRK20.51798850
77RPS6KC10.49055373
78RPS6KL10.49055373
79SIK10.48558710
80MAP3K120.46975832
81OXSR10.46582879
82SMG10.46410140
83PRKCI0.44866174
84CDC70.44818381
85PAK60.42641586
86PRKACA0.42415470
87VRK10.40533410
88DDR20.40331088
89TNIK0.39065566
90DMPK0.38080394
91CSNK2A10.36252549
92CSNK1G30.34625455
93FGFR20.34335800
94CSNK2A20.33759940
95DAPK30.32879352
96CSNK1E0.31799826
97MAPKAPK50.30670731
98CSNK1A1L0.29507812
99PRKG10.28437673
100AKT10.28345562

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.34443093
2Oxidative phosphorylation_Homo sapiens_hsa001903.66265428
3Parkinsons disease_Homo sapiens_hsa050123.02901765
4Cardiac muscle contraction_Homo sapiens_hsa042602.76863343
5Sulfur relay system_Homo sapiens_hsa041222.60378914
6Huntingtons disease_Homo sapiens_hsa050162.59423994
7Alzheimers disease_Homo sapiens_hsa050102.36445236
8RNA polymerase_Homo sapiens_hsa030202.18185424
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09208992
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04852781
11Tight junction_Homo sapiens_hsa045302.03204820
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84415379
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57936878
14Regulation of autophagy_Homo sapiens_hsa041401.50056514
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44254890
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43411637
17Nicotine addiction_Homo sapiens_hsa050331.40842266
18Spliceosome_Homo sapiens_hsa030401.36621141
19Proteasome_Homo sapiens_hsa030501.33825991
20Insulin secretion_Homo sapiens_hsa049111.21196650
21Hedgehog signaling pathway_Homo sapiens_hsa043401.20479495
22Basal cell carcinoma_Homo sapiens_hsa052171.20092496
23RNA degradation_Homo sapiens_hsa030181.15591383
24Nitrogen metabolism_Homo sapiens_hsa009101.13835991
25Morphine addiction_Homo sapiens_hsa050321.13683833
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13270568
27Folate biosynthesis_Homo sapiens_hsa007901.12967511
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12416066
29Pyrimidine metabolism_Homo sapiens_hsa002401.09126618
30Linoleic acid metabolism_Homo sapiens_hsa005911.05296822
31Oxytocin signaling pathway_Homo sapiens_hsa049211.01823015
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00492755
33One carbon pool by folate_Homo sapiens_hsa006700.99615033
34Dopaminergic synapse_Homo sapiens_hsa047280.99272013
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97158448
36Fanconi anemia pathway_Homo sapiens_hsa034600.93580255
37Protein export_Homo sapiens_hsa030600.91772445
38Circadian entrainment_Homo sapiens_hsa047130.88131612
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87484956
40Wnt signaling pathway_Homo sapiens_hsa043100.86886399
41Basal transcription factors_Homo sapiens_hsa030220.84718155
42Phototransduction_Homo sapiens_hsa047440.83083855
43Synaptic vesicle cycle_Homo sapiens_hsa047210.82391449
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80541881
45Cholinergic synapse_Homo sapiens_hsa047250.79292563
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76541533
47Ether lipid metabolism_Homo sapiens_hsa005650.75354594
48Glutathione metabolism_Homo sapiens_hsa004800.74997062
49Purine metabolism_Homo sapiens_hsa002300.74911640
50Arginine biosynthesis_Homo sapiens_hsa002200.73679482
51Melanoma_Homo sapiens_hsa052180.73661707
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.72509899
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72436175
54Pancreatic secretion_Homo sapiens_hsa049720.71098433
55Homologous recombination_Homo sapiens_hsa034400.70639364
56Axon guidance_Homo sapiens_hsa043600.70606292
57Peroxisome_Homo sapiens_hsa041460.70301874
58Calcium signaling pathway_Homo sapiens_hsa040200.68575058
59RNA transport_Homo sapiens_hsa030130.68487587
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68234549
61Gastric acid secretion_Homo sapiens_hsa049710.66567520
62Glutamatergic synapse_Homo sapiens_hsa047240.65892411
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65179067
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64200736
65Nucleotide excision repair_Homo sapiens_hsa034200.63122441
66GABAergic synapse_Homo sapiens_hsa047270.62129204
67Long-term depression_Homo sapiens_hsa047300.61837554
68Chemical carcinogenesis_Homo sapiens_hsa052040.58303888
69Olfactory transduction_Homo sapiens_hsa047400.56741397
70Serotonergic synapse_Homo sapiens_hsa047260.55052094
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53503153
72Salivary secretion_Homo sapiens_hsa049700.52637530
73Glucagon signaling pathway_Homo sapiens_hsa049220.51470015
74Metabolic pathways_Homo sapiens_hsa011000.51172389
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48909967
76Notch signaling pathway_Homo sapiens_hsa043300.48527030
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.47476705
78Cocaine addiction_Homo sapiens_hsa050300.47314014
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46123648
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45941235
81Hippo signaling pathway_Homo sapiens_hsa043900.45876682
82MAPK signaling pathway_Homo sapiens_hsa040100.44587610
83Arginine and proline metabolism_Homo sapiens_hsa003300.44246992
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44100547
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42846070
86Dilated cardiomyopathy_Homo sapiens_hsa054140.42393743
87DNA replication_Homo sapiens_hsa030300.41324817
88Amphetamine addiction_Homo sapiens_hsa050310.39768615
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39515563
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.39004237
91Fat digestion and absorption_Homo sapiens_hsa049750.38304216
92Alcoholism_Homo sapiens_hsa050340.37639137
93Caffeine metabolism_Homo sapiens_hsa002320.37213159
94Taste transduction_Homo sapiens_hsa047420.36992888
95Arachidonic acid metabolism_Homo sapiens_hsa005900.35164101
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35078179
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.33028248
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32819696
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31468622
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30078530

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