ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.54220566
2	viral transcription (GO:0019083)	7.41244824
3	translational termination (GO:0006415)	7.19271449
4	translational elongation (GO:0006414)	6.42417841
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.19228218
6	cotranslational protein targeting to membrane (GO:0006613)	6.09153648
7	protein targeting to ER (GO:0045047)	6.05967141
8	ribosomal small subunit biogenesis (GO:0042274)	5.97912128
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.79107865
10	protein localization to endoplasmic reticulum (GO:0070972)	5.66715335
11	maturation of SSU-rRNA (GO:0030490)	5.53563950
12	cellular protein complex disassembly (GO:0043624)	5.51488521
13	DNA deamination (GO:0045006)	5.33802172
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.21079178
15	ATP synthesis coupled proton transport (GO:0015986)	5.21079178
16	viral life cycle (GO:0019058)	5.20096270
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.17678718
18	CTP biosynthetic process (GO:0006241)	4.91823226
19	CTP metabolic process (GO:0046036)	4.91823226
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.90429407
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.90429407
22	translational initiation (GO:0006413)	4.87286790
23	protein complex disassembly (GO:0043241)	4.69807297
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.61682017
25	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.58491008
26	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.52550018
27	macromolecular complex disassembly (GO:0032984)	4.48717669
28	nucleotide salvage (GO:0043173)	4.46968857
29	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.43404800
30	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	4.39063277
31	chaperone-mediated protein transport (GO:0072321)	4.36112406
32	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.31855461
33	UMP biosynthetic process (GO:0006222)	4.31855461
34	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.31855461
35	UMP metabolic process (GO:0046049)	4.31855461
36	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.29129313
37	translation (GO:0006412)	4.25098929
38	GTP biosynthetic process (GO:0006183)	4.23126669
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.19813357
40	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.17555017
41	water-soluble vitamin biosynthetic process (GO:0042364)	4.12430725
42	protein targeting to membrane (GO:0006612)	3.97693503
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.97689986
44	protein complex biogenesis (GO:0070271)	3.93252629
45	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.87352469
46	behavioral response to nicotine (GO:0035095)	3.85067279
47	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.78791640
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.77910169
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.75709549
50	UTP biosynthetic process (GO:0006228)	3.74032732
51	respiratory electron transport chain (GO:0022904)	3.72719075
52	nucleoside salvage (GO:0043174)	3.72605456
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.71463988
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.71463988
55	NADH dehydrogenase complex assembly (GO:0010257)	3.71463988
56	electron transport chain (GO:0022900)	3.69666221
57	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.64747468
58	ribosomal large subunit biogenesis (GO:0042273)	3.62683604
59	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.59393042
60	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.56948224
61	mRNA catabolic process (GO:0006402)	3.53497353
62	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.53482820
63	protein neddylation (GO:0045116)	3.48475541
64	UTP metabolic process (GO:0046051)	3.47855867
65	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.47835892
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41152601
67	cytidine deamination (GO:0009972)	3.39705682
68	cytidine metabolic process (GO:0046087)	3.39705682
69	cytidine catabolic process (GO:0006216)	3.39705682
70	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.36207933
71	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.30870122
72	termination of RNA polymerase III transcription (GO:0006386)	3.28672019
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.28672019
74	RNA catabolic process (GO:0006401)	3.25408585
75	nucleoside triphosphate biosynthetic process (GO:0009142)	3.16443727
76	ATP biosynthetic process (GO:0006754)	3.15266054
77	pyrimidine nucleoside salvage (GO:0043097)	3.11219899
78	pyrimidine-containing compound salvage (GO:0008655)	3.11219899
79	cellular component biogenesis (GO:0044085)	3.09872950
80	hydrogen ion transmembrane transport (GO:1902600)	3.06999608
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04661826
82	purine nucleotide salvage (GO:0032261)	3.03550310
83	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.00073156
84	guanosine-containing compound biosynthetic process (GO:1901070)	2.99157519
85	pyrimidine nucleotide metabolic process (GO:0006220)	2.97341845
86	ribonucleoprotein complex biogenesis (GO:0022613)	2.95339389
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.95131345
88	pseudouridine synthesis (GO:0001522)	2.92268388
89	response to pheromone (GO:0019236)	2.90591632
90	pyrimidine nucleotide catabolic process (GO:0006244)	2.89026132
91	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.85255477
92	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.83072377
93	respiratory chain complex IV assembly (GO:0008535)	2.74424096
94	base-excision repair, AP site formation (GO:0006285)	2.73626657
95	proton transport (GO:0015992)	2.73499684
96	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.72839329
97	pyrimidine nucleoside metabolic process (GO:0006213)	2.71268756
98	ncRNA 3-end processing (GO:0043628)	2.69435784
99	iron-sulfur cluster assembly (GO:0016226)	2.68839447
100	metallo-sulfur cluster assembly (GO:0031163)	2.68839447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.91276700
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.82622119
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.35443383
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19202400
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07350281
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.98893228
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.96091045
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88177069
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71288261
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.70316547
11	VDR_22108803_ChIP-Seq_LS180_Human	2.63879560
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50441814
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.44227477
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.32156197
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.17043734
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09162012
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.07861901
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04662159
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.01433767
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99565258
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97548011
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.94629497
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.91863743
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.90896116
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.87700039
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.86900738
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.83244946
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77784311
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.73027770
30	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.72761694
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.68286212
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.63529765
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.61029766
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59199970
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52360388
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48728476
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43246412
38	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.41971076
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41781740
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41491736
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37694800
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37159540
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.36844169
44	ERA_21632823_ChIP-Seq_H3396_Human	1.27475529
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.27349033
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26044679
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25940958
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.25626404
49	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.22408628
50	EWS_26573619_Chip-Seq_HEK293_Human	1.20619345
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.19338695
52	NCOR_22424771_ChIP-Seq_293T_Human	1.18801689
53	P53_21459846_ChIP-Seq_SAOS-2_Human	1.17524977
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16893612
55	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16789756
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.16764569
57	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.15155953
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14666816
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14008155
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.13276671
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11030153
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10717049
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10219061
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.10184976
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08033541
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06992767
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06935684
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06841602
69	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06452974
70	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05643012
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05635618
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05281664
73	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.03577688
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01481760
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.00865613
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96743691
77	AR_20517297_ChIP-Seq_VCAP_Human	0.95899505
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.94416846
79	FUS_26573619_Chip-Seq_HEK293_Human	0.94346270
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94306190
81	DCP1A_22483619_ChIP-Seq_HELA_Human	0.92164817
82	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92082220
83	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91825170
84	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.91711146
85	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91701664
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91577046
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91577046
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90490673
89	E2F1_20622854_ChIP-Seq_HELA_Human	0.90442430
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89413424
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88887943
92	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.88170072
93	BCL6_27268052_Chip-Seq_Bcells_Human	0.87017564
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86174399
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86030351
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.85139209
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.84012174
98	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.83437030
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.83350651
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.82893683

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.17354093
2	MP0009379_abnormal_foot_pigmentation	4.83703369
3	MP0002163_abnormal_gland_morphology	3.03474718
4	MP0008875_abnormal_xenobiotic_pharmacok	2.83871561
5	MP0003646_muscle_fatigue	2.61489339
6	MP0002837_dystrophic_cardiac_calcinosis	2.48919031
7	MP0005671_abnormal_response_to	2.30344086
8	MP0006072_abnormal_retinal_apoptosis	2.16556180
9	MP0002102_abnormal_ear_morphology	2.15271946
10	MP0005645_abnormal_hypothalamus_physiol	2.12689482
11	MP0008872_abnormal_physiological_respon	2.12158871
12	MP0005377_hearing/vestibular/ear_phenot	2.06918410
13	MP0003878_abnormal_ear_physiology	2.06918410
14	MP0004142_abnormal_muscle_tone	1.90227631
15	MP0003787_abnormal_imprinting	1.85645257
16	MP0005646_abnormal_pituitary_gland	1.85415998
17	MP0008877_abnormal_DNA_methylation	1.75680925
18	MP0005379_endocrine/exocrine_gland_phen	1.72857290
19	MP0004885_abnormal_endolymph	1.72095272
20	MP0008789_abnormal_olfactory_epithelium	1.72081908
21	MP0001293_anophthalmia	1.71729376
22	MP0002653_abnormal_ependyma_morphology	1.69160585
23	MP0001968_abnormal_touch/_nociception	1.66312186
24	MP0001485_abnormal_pinna_reflex	1.66274348
25	MP0002138_abnormal_hepatobiliary_system	1.65369966
26	MP0005084_abnormal_gallbladder_morpholo	1.63682788
27	MP0005389_reproductive_system_phenotype	1.58931941
28	MP0001919_abnormal_reproductive_system	1.55933117
29	MP0005551_abnormal_eye_electrophysiolog	1.52948254
30	MP0002638_abnormal_pupillary_reflex	1.51810668
31	MP0002938_white_spotting	1.44500277
32	MP0006276_abnormal_autonomic_nervous	1.38824867
33	MP0000049_abnormal_middle_ear	1.35316592
34	MP0001873_stomach_inflammation	1.34084995
35	MP0002736_abnormal_nociception_after	1.33252554
36	MP0001835_abnormal_antigen_presentation	1.31430610
37	MP0005360_urolithiasis	1.27948809
38	MP0003195_calcinosis	1.26717658
39	MP0003567_abnormal_fetal_cardiomyocyte	1.26695199
40	MP0008058_abnormal_DNA_repair	1.24824067
41	MP0000631_abnormal_neuroendocrine_gland	1.24545065
42	MP0002160_abnormal_reproductive_system	1.23387099
43	MP0001905_abnormal_dopamine_level	1.22403093
44	MP0001529_abnormal_vocalization	1.21176365
45	MP0000372_irregular_coat_pigmentation	1.20834144
46	MP0004145_abnormal_muscle_electrophysio	1.20182515
47	MP0001984_abnormal_olfaction	1.19377688
48	MP0002234_abnormal_pharynx_morphology	1.19162449
49	MP0008995_early_reproductive_senescence	1.16836436
50	MP0001986_abnormal_taste_sensitivity	1.15847205
51	MP0002272_abnormal_nervous_system	1.15451764
52	MP0005394_taste/olfaction_phenotype	1.13215476
53	MP0005499_abnormal_olfactory_system	1.13215476
54	MP0003136_yellow_coat_color	1.12962492
55	MP0003123_paternal_imprinting	1.12295115
56	MP0003011_delayed_dark_adaptation	1.12179438
57	MP0003880_abnormal_central_pattern	1.11004817
58	MP0009745_abnormal_behavioral_response	1.09183343
59	MP0003786_premature_aging	1.07185980
60	MP0003122_maternal_imprinting	1.01090510
61	MP0004742_abnormal_vestibular_system	0.98512240
62	MP0001348_abnormal_lacrimal_gland	0.98009838
63	MP0003806_abnormal_nucleotide_metabolis	0.96042259
64	MP0002733_abnormal_thermal_nociception	0.92590531
65	MP0002095_abnormal_skin_pigmentation	0.92106370
66	MP0003186_abnormal_redox_activity	0.91172225
67	MP0003283_abnormal_digestive_organ	0.88555843
68	MP0002277_abnormal_respiratory_mucosa	0.88531538
69	MP0001970_abnormal_pain_threshold	0.85396679
70	MP0003252_abnormal_bile_duct	0.84253425
71	MP0000613_abnormal_salivary_gland	0.84123465
72	MP0005332_abnormal_amino_acid	0.81836320
73	MP0005253_abnormal_eye_physiology	0.81164542
74	MP0003121_genomic_imprinting	0.81043616
75	MP0009785_altered_susceptibility_to	0.80460119
76	MP0004133_heterotaxia	0.77953254
77	MP0005410_abnormal_fertilization	0.77625949
78	MP0003938_abnormal_ear_development	0.77519277
79	MP0003718_maternal_effect	0.77212195
80	MP0001800_abnormal_humoral_immune	0.76177894
81	MP0004147_increased_porphyrin_level	0.73816771
82	MP0005636_abnormal_mineral_homeostasis	0.71933956
83	MP0001486_abnormal_startle_reflex	0.71087176
84	MP0005195_abnormal_posterior_eye	0.70985027
85	MP0009643_abnormal_urine_homeostasis	0.70017353
86	MP0002876_abnormal_thyroid_physiology	0.69250355
87	MP0001119_abnormal_female_reproductive	0.69080456
88	MP0003119_abnormal_digestive_system	0.68932768
89	MP0003693_abnormal_embryo_hatching	0.68878168
90	MP0000026_abnormal_inner_ear	0.68609589
91	MP0001963_abnormal_hearing_physiology	0.68349713
92	MP0002557_abnormal_social/conspecific_i	0.68073181
93	MP0003937_abnormal_limbs/digits/tail_de	0.67831122
94	MP0006036_abnormal_mitochondrial_physio	0.66765422
95	MP0002752_abnormal_somatic_nervous	0.65744034
96	MP0000566_synostosis	0.64768755
97	MP0002148_abnormal_hypersensitivity_rea	0.62929017
98	MP0002210_abnormal_sex_determination	0.61367951
99	MP0008775_abnormal_heart_ventricle	0.60852187
100	MP0006035_abnormal_mitochondrial_morpho	0.60590085

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.75415612
2	Acute necrotizing encephalopathy (HP:0006965)	4.62607538
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.15149205
4	Mitochondrial inheritance (HP:0001427)	4.08979386
5	Acute encephalopathy (HP:0006846)	4.08024174
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.02096586
7	Increased hepatocellular lipid droplets (HP:0006565)	3.78525569
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.76398805
9	Progressive macrocephaly (HP:0004481)	3.73806205
10	Increased CSF lactate (HP:0002490)	3.58688744
11	Macrocytic anemia (HP:0001972)	3.48360363
12	Lipid accumulation in hepatocytes (HP:0006561)	3.45771856
13	Abnormal number of erythroid precursors (HP:0012131)	3.45089848
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.32096603
15	3-Methylglutaconic aciduria (HP:0003535)	3.30656488
16	Hepatocellular necrosis (HP:0001404)	3.15910206
17	Hyperglycinemia (HP:0002154)	3.13765377
18	Cerebral edema (HP:0002181)	3.04491075
19	Pancreatic fibrosis (HP:0100732)	2.99747841
20	Pancreatic cysts (HP:0001737)	2.96246984
21	Colon cancer (HP:0003003)	2.86093628
22	Hepatic necrosis (HP:0002605)	2.85975264
23	Renal Fanconi syndrome (HP:0001994)	2.84013454
24	Increased intramyocellular lipid droplets (HP:0012240)	2.82580548
25	Optic disc pallor (HP:0000543)	2.81998257
26	Congenital stationary night blindness (HP:0007642)	2.79656507
27	Septo-optic dysplasia (HP:0100842)	2.74560475
28	Pallor (HP:0000980)	2.71171298
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62859834
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.60286251
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.60286251
32	Asplenia (HP:0001746)	2.59969543
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.53520335
34	Hypoplasia of the pons (HP:0012110)	2.52191820
35	Increased serum lactate (HP:0002151)	2.52062424
36	Abolished electroretinogram (ERG) (HP:0000550)	2.51906906
37	Abnormality of the pons (HP:0007361)	2.51639996
38	Absent thumb (HP:0009777)	2.50136969
39	True hermaphroditism (HP:0010459)	2.48428272
40	Aplastic anemia (HP:0001915)	2.45814393
41	Lactic acidosis (HP:0003128)	2.43788128
42	Exertional dyspnea (HP:0002875)	2.41682083
43	Pancytopenia (HP:0001876)	2.36175100
44	Increased muscle lipid content (HP:0009058)	2.29094918
45	Abnormality of midbrain morphology (HP:0002418)	2.28311138
46	Molar tooth sign on MRI (HP:0002419)	2.28311138
47	Constricted visual fields (HP:0001133)	2.27682614
48	Rib fusion (HP:0000902)	2.25629551
49	IgG deficiency (HP:0004315)	2.24720257
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23426075
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.23426075
52	Pendular nystagmus (HP:0012043)	2.20388840
53	Attenuation of retinal blood vessels (HP:0007843)	2.19402548
54	Elevated erythrocyte sedimentation rate (HP:0003565)	2.18628805
55	Maternal diabetes (HP:0009800)	2.17524043
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13417875
57	Sclerocornea (HP:0000647)	2.11058713
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10615202
59	Absent/shortened dynein arms (HP:0200106)	2.10615202
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.09388844
61	Respiratory failure (HP:0002878)	2.08052518
62	Congenital, generalized hypertrichosis (HP:0004540)	2.07089695
63	Decreased central vision (HP:0007663)	2.06424900
64	Lethargy (HP:0001254)	2.00010587
65	Exercise intolerance (HP:0003546)	1.99442364
66	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.99358146
67	Nephronophthisis (HP:0000090)	1.98467100
68	Hip dysplasia (HP:0001385)	1.97767876
69	Supernumerary spleens (HP:0009799)	1.93095588
70	Type II lissencephaly (HP:0007260)	1.92146597
71	Glycosuria (HP:0003076)	1.90417309
72	Abnormality of urine glucose concentration (HP:0011016)	1.90417309
73	Hypoplasia of the radius (HP:0002984)	1.89574615
74	Hypoplasia of the ulna (HP:0003022)	1.87855510
75	Abnormality of the renal collecting system (HP:0004742)	1.87330886
76	Triphalangeal thumb (HP:0001199)	1.87165363
77	Leukodystrophy (HP:0002415)	1.86399607
78	Postaxial foot polydactyly (HP:0001830)	1.82827942
79	Abnormality of renal resorption (HP:0011038)	1.82068896
80	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.79237058
81	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78888416
82	Forearm undergrowth (HP:0009821)	1.78745002
83	Cystic liver disease (HP:0006706)	1.77521821
84	Abnormality of the renal cortex (HP:0011035)	1.76943799
85	Abnormality of the labia minora (HP:0012880)	1.76840520
86	Respiratory difficulties (HP:0002880)	1.76795535
87	Abnormality of the renal medulla (HP:0100957)	1.76105786
88	Abnormal ciliary motility (HP:0012262)	1.74452814
89	Hyperphosphaturia (HP:0003109)	1.73513848
90	Absent septum pellucidum (HP:0001331)	1.72103690
91	Optic nerve hypoplasia (HP:0000609)	1.70520407
92	Stenosis of the external auditory canal (HP:0000402)	1.70445040
93	Opisthotonus (HP:0002179)	1.69216543
94	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.68500072
95	Abnormality of serum amino acid levels (HP:0003112)	1.68044611
96	Abnormal drinking behavior (HP:0030082)	1.67175317
97	Polydipsia (HP:0001959)	1.67175317
98	Abnormality of glycine metabolism (HP:0010895)	1.66714046
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.66714046
100	Anencephaly (HP:0002323)	1.66256370

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.64178206
2	ZAK	3.63576161
3	TXK	3.14823959
4	MAP4K2	3.05851354
5	LIMK1	2.79858552
6	BCKDK	2.71939102
7	ADRBK2	2.58620424
8	WNK4	2.49398230
9	VRK2	2.36907130
10	MAP4K1	2.25443441
11	STK16	2.14093026
12	KDR	2.12077272
13	PLK4	1.85466999
14	NUAK1	1.82214678
15	TAF1	1.82137798
16	GRK1	1.73777886
17	VRK1	1.71422690
18	DYRK2	1.60415589
19	BMPR1B	1.59577442
20	NME2	1.57836800
21	WNK3	1.43543458
22	STK39	1.39881644
23	PASK	1.33396001
24	ITK	1.31116634
25	CDC7	1.26965038
26	TIE1	1.25582244
27	PINK1	1.22279884
28	CDK8	1.21145023
29	MST4	1.18445924
30	FRK	1.14787300
31	MAP3K11	1.10001106
32	AURKA	1.09979702
33	PRKCQ	1.09418849
34	LRRK2	1.05838141
35	TESK2	1.05770859
36	CDK19	1.02004695
37	TNIK	0.95959870
38	ADRBK1	0.95902931
39	PLK2	0.95863618
40	CSNK1G1	0.95242480
41	PRKCG	0.95180021
42	RPS6KA5	0.90835671
43	TEC	0.88495157
44	EPHA4	0.85901071
45	PLK1	0.84983202
46	MAP3K12	0.84461443
47	INSRR	0.80445363
48	NME1	0.80355332
49	CSNK2A2	0.79653703
50	CSNK1G3	0.75485354
51	DAPK3	0.74348850
52	OXSR1	0.73936083
53	MAP2K7	0.70890802
54	PIK3CG	0.69039621
55	BTK	0.68382184
56	TESK1	0.68309303
57	CSNK1G2	0.68086490
58	CSNK2A1	0.66197247
59	TAOK3	0.65137774
60	NLK	0.63648303
61	CSF1R	0.63375870
62	GRK7	0.63072191
63	PBK	0.62539288
64	DAPK2	0.62470765
65	CAMK1	0.62440748
66	SYK	0.62302682
67	ATR	0.58947619
68	TYRO3	0.58350244
69	LCK	0.57184697
70	RPS6KA4	0.57163396
71	OBSCN	0.55023125
72	AURKB	0.54046095
73	CAMKK2	0.53152343
74	MUSK	0.52262213
75	MAP3K4	0.51703967
76	LYN	0.51464360
77	CSNK1A1L	0.51403772
78	PKN1	0.51267864
79	TNK2	0.50154022
80	PRKACA	0.49289898
81	PRKCA	0.48113326
82	TGFBR1	0.47950601
83	KIT	0.47929719
84	IKBKE	0.47804120
85	PLK3	0.47800180
86	CSNK1A1	0.44461302
87	IKBKB	0.42189816
88	PIM2	0.42166364
89	MAP2K2	0.40300095
90	CHEK2	0.39050222
91	NTRK2	0.38186101
92	BUB1	0.37974454
93	PIM1	0.37089868
94	ABL2	0.36707297
95	PAK1	0.34828600
96	PRKCD	0.34464926
97	PIK3CA	0.32226496
98	RPS6KB2	0.32147083
99	RPS6KA6	0.31852406
100	GRK5	0.30840961

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.08753091
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.86878716
3	Parkinsons disease_Homo sapiens_hsa05012	3.27590110
4	Proteasome_Homo sapiens_hsa03050	2.60414108
5	RNA polymerase_Homo sapiens_hsa03020	2.60233303
6	Sulfur relay system_Homo sapiens_hsa04122	2.47038808
7	Huntingtons disease_Homo sapiens_hsa05016	2.21384822
8	Alzheimers disease_Homo sapiens_hsa05010	2.20492788
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.05144103
10	DNA replication_Homo sapiens_hsa03030	2.01084211
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00131924
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.97990263
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.94930283
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.92224091
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87448790
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72704889
17	Protein export_Homo sapiens_hsa03060	1.71042265
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69394286
19	Mismatch repair_Homo sapiens_hsa03430	1.63959897
20	Homologous recombination_Homo sapiens_hsa03440	1.55719211
21	Phototransduction_Homo sapiens_hsa04744	1.52369635
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50710638
23	Sulfur metabolism_Homo sapiens_hsa00920	1.49949311
24	RNA degradation_Homo sapiens_hsa03018	1.45315657
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.33198575
26	Allograft rejection_Homo sapiens_hsa05330	1.33138520
27	One carbon pool by folate_Homo sapiens_hsa00670	1.31224834
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28998271
29	Asthma_Homo sapiens_hsa05310	1.27360883
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24741458
31	Base excision repair_Homo sapiens_hsa03410	1.23043113
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21990910
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.19909610
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.15530775
35	Purine metabolism_Homo sapiens_hsa00230	1.12093995
36	Basal transcription factors_Homo sapiens_hsa03022	1.10290740
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.09302093
38	Caffeine metabolism_Homo sapiens_hsa00232	1.08519158
39	Graft-versus-host disease_Homo sapiens_hsa05332	1.03729411
40	Peroxisome_Homo sapiens_hsa04146	1.02786098
41	Butanoate metabolism_Homo sapiens_hsa00650	1.02729882
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.00245723
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99580980
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.98897050
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98740442
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97827836
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94372258
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.94056551
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92356164
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.91339361
51	Propanoate metabolism_Homo sapiens_hsa00640	0.87066920
52	Nicotine addiction_Homo sapiens_hsa05033	0.86976546
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86833666
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85635335
55	Metabolic pathways_Homo sapiens_hsa01100	0.80655517
56	Spliceosome_Homo sapiens_hsa03040	0.79167351
57	Olfactory transduction_Homo sapiens_hsa04740	0.73736750
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.73683305
59	Retinol metabolism_Homo sapiens_hsa00830	0.72365555
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.71100175
61	RNA transport_Homo sapiens_hsa03013	0.70675666
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70347963
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.69238867
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65670604
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62558471
66	Fatty acid elongation_Homo sapiens_hsa00062	0.60921560
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59638889
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58205942
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57018858
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56840242
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56387576
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56156950
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55583362
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54858826
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52973523
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52347618
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50332261
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49190597
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48633619
80	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48303878
81	Morphine addiction_Homo sapiens_hsa05032	0.46376697
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.45004900
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41658099
84	Folate biosynthesis_Homo sapiens_hsa00790	0.41129250
85	Taste transduction_Homo sapiens_hsa04742	0.38953883
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37609623
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.36957539
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35888655
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.33808567
90	Glutathione metabolism_Homo sapiens_hsa00480	0.32747394
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32657968
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31936420
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31440742
94	Pentose phosphate pathway_Homo sapiens_hsa00030	0.30824194
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.28669598
96	Serotonergic synapse_Homo sapiens_hsa04726	0.27382280
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25313819
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.24288500
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.22724473
100	Salivary secretion_Homo sapiens_hsa04970	0.22320250

RPSAP29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »