ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.65398977
2	viral transcription (GO:0019083)	5.44514704
3	translational termination (GO:0006415)	5.26101749
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.95433961
5	ATP synthesis coupled proton transport (GO:0015986)	4.93687056
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.93687056
7	ribosomal small subunit biogenesis (GO:0042274)	4.91478855
8	maturation of SSU-rRNA (GO:0030490)	4.84605386
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.66621265
10	translational elongation (GO:0006414)	4.65698629
11	DNA deamination (GO:0045006)	4.62817219
12	cotranslational protein targeting to membrane (GO:0006613)	4.60675437
13	protein targeting to ER (GO:0045047)	4.57816763
14	protein neddylation (GO:0045116)	4.52483382
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.41889392
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.40539854
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.35627115
18	protein localization to endoplasmic reticulum (GO:0070972)	4.35292693
19	behavioral response to nicotine (GO:0035095)	4.33482899
20	protein complex biogenesis (GO:0070271)	4.29049377
21	piRNA metabolic process (GO:0034587)	4.28608548
22	chaperone-mediated protein transport (GO:0072321)	4.26617926
23	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.24242644
24	ncRNA 3-end processing (GO:0043628)	4.06750486
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.06611943
26	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.06441297
27	viral life cycle (GO:0019058)	4.03316408
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.00037950
29	cellular protein complex disassembly (GO:0043624)	3.98040058
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97981116
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97981116
32	NADH dehydrogenase complex assembly (GO:0010257)	3.97981116
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.95895592
34	translational initiation (GO:0006413)	3.88742736
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.81055984
36	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.79641656
37	base-excision repair, AP site formation (GO:0006285)	3.79483140
38	GTP biosynthetic process (GO:0006183)	3.72745182
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.70986945
40	proteasome assembly (GO:0043248)	3.62888549
41	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.53199060
42	translation (GO:0006412)	3.50178263
43	ribosomal large subunit biogenesis (GO:0042273)	3.49660764
44	pyrimidine nucleotide catabolic process (GO:0006244)	3.41873620
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39196734
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39196734
47	protein polyglutamylation (GO:0018095)	3.30861802
48	electron transport chain (GO:0022900)	3.30757066
49	axoneme assembly (GO:0035082)	3.29970546
50	respiratory electron transport chain (GO:0022904)	3.29554771
51	protein complex disassembly (GO:0043241)	3.27013125
52	cellular component biogenesis (GO:0044085)	3.26795376
53	rRNA modification (GO:0000154)	3.21607654
54	UTP biosynthetic process (GO:0006228)	3.20407859
55	DNA methylation involved in gamete generation (GO:0043046)	3.19794883
56	cytidine metabolic process (GO:0046087)	3.19296040
57	cytidine catabolic process (GO:0006216)	3.19296040
58	cytidine deamination (GO:0009972)	3.19296040
59	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.18508824
60	macromolecular complex disassembly (GO:0032984)	3.14756975
61	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.09215473
62	termination of RNA polymerase III transcription (GO:0006386)	3.09215473
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.04495747
64	male meiosis I (GO:0007141)	3.04433199
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.03651064
66	UTP metabolic process (GO:0046051)	3.03089055
67	cytochrome complex assembly (GO:0017004)	3.00853409
68	resolution of meiotic recombination intermediates (GO:0000712)	3.00411891
69	mRNA catabolic process (GO:0006402)	3.00140071
70	pseudouridine synthesis (GO:0001522)	3.00137229
71	ribonucleoprotein complex biogenesis (GO:0022613)	2.99816257
72	peptidyl-histidine modification (GO:0018202)	2.98994645
73	protein-cofactor linkage (GO:0018065)	2.98943970
74	rRNA processing (GO:0006364)	2.98027550
75	aldehyde catabolic process (GO:0046185)	2.94756390
76	rRNA metabolic process (GO:0016072)	2.93746293
77	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.93073298
78	nonmotile primary cilium assembly (GO:0035058)	2.89772883
79	protein targeting to membrane (GO:0006612)	2.88954653
80	regulation of mitochondrial translation (GO:0070129)	2.87420818
81	ATP biosynthetic process (GO:0006754)	2.82943294
82	intracellular protein transmembrane import (GO:0044743)	2.82512730
83	CTP biosynthetic process (GO:0006241)	2.82479086
84	CTP metabolic process (GO:0046036)	2.82479086
85	respiratory chain complex IV assembly (GO:0008535)	2.76145586
86	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.76044458
87	RNA catabolic process (GO:0006401)	2.73592707
88	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72256243
89	hydrogen ion transmembrane transport (GO:1902600)	2.71908966
90	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.69899657
91	indolalkylamine metabolic process (GO:0006586)	2.66218980
92	platelet dense granule organization (GO:0060155)	2.63476255
93	replication fork processing (GO:0031297)	2.62968624
94	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.58884030
95	proton transport (GO:0015992)	2.56484944
96	inner mitochondrial membrane organization (GO:0007007)	2.56306238
97	tRNA processing (GO:0008033)	2.53246257
98	rRNA methylation (GO:0031167)	2.51838129
99	guanosine-containing compound biosynthetic process (GO:1901070)	2.51689883
100	regulation of cellular amino acid metabolic process (GO:0006521)	2.50805113

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.19225724
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.41330061
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.87898105
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65083915
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.64090828
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43682640
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12272297
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06990633
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.06890107
10	VDR_22108803_ChIP-Seq_LS180_Human	2.95417121
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.87378011
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.47801850
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.45425870
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.41565072
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25426326
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.23028039
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.12117640
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.10009670
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03805108
20	IRF1_19129219_ChIP-ChIP_H3396_Human	2.02329803
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91320757
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91091156
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89120198
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80077272
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79845057
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78196945
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77835305
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72779207
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.72260625
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70432976
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69406487
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.68687783
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.67618542
34	EWS_26573619_Chip-Seq_HEK293_Human	1.62795490
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60852067
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.60805446
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58042076
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57530455
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.53261400
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51816862
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.46260667
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37579261
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37134387
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30454283
45	NCOR_22424771_ChIP-Seq_293T_Human	1.25883356
46	XRN2_22483619_ChIP-Seq_HELA_Human	1.24818844
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23495915
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23358085
49	FUS_26573619_Chip-Seq_HEK293_Human	1.17438252
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16373488
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15968843
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.15714522
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15082590
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15082590
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14488158
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.13129502
57	AR_20517297_ChIP-Seq_VCAP_Human	1.10194751
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09872335
59	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05670437
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05356440
61	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.05149606
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04488998
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03756930
64	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03485370
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03241618
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02359488
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01971987
68	ERA_21632823_ChIP-Seq_H3396_Human	1.01964944
69	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01168039
70	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99707934
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99320694
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99080587
73	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98940155
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98443040
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97413569
76	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96938925
77	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.95548413
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94638475
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.93697773
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93198845
81	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92881549
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91488431
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91488431
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90340029
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88476878
86	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87307796
87	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87184919
88	MYC_19829295_ChIP-Seq_ESCs_Human	0.87177133
89	ER_23166858_ChIP-Seq_MCF-7_Human	0.86599963
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86428555
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85530031
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.85261485
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.85198743
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.85074961
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83628851
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.83611146
97	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.82742083
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82402499
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.81400436
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81201390

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.80177448
2	MP0002837_dystrophic_cardiac_calcinosis	3.45319211
3	MP0009379_abnormal_foot_pigmentation	3.38766983
4	MP0003646_muscle_fatigue	3.23574007
5	MP0008877_abnormal_DNA_methylation	3.02345786
6	MP0003122_maternal_imprinting	2.65586248
7	MP0002138_abnormal_hepatobiliary_system	2.60892084
8	MP0003787_abnormal_imprinting	2.31801443
9	MP0001968_abnormal_touch/_nociception	2.26516753
10	MP0004147_increased_porphyrin_level	2.12782195
11	MP0001529_abnormal_vocalization	1.98245550
12	MP0004142_abnormal_muscle_tone	1.96422417
13	MP0008789_abnormal_olfactory_epithelium	1.88902292
14	MP0002163_abnormal_gland_morphology	1.84060802
15	MP0003121_genomic_imprinting	1.83389752
16	MP0002102_abnormal_ear_morphology	1.82556653
17	MP0002653_abnormal_ependyma_morphology	1.81635751
18	MP0004145_abnormal_muscle_electrophysio	1.80795240
19	MP0005645_abnormal_hypothalamus_physiol	1.75306448
20	MP0005671_abnormal_response_to	1.73796754
21	MP0001905_abnormal_dopamine_level	1.69738204
22	MP0008058_abnormal_DNA_repair	1.68387979
23	MP0005084_abnormal_gallbladder_morpholo	1.67189407
24	MP0008875_abnormal_xenobiotic_pharmacok	1.65702334
25	MP0006072_abnormal_retinal_apoptosis	1.63289778
26	MP0002876_abnormal_thyroid_physiology	1.62508555
27	MP0002938_white_spotting	1.60800101
28	MP0002736_abnormal_nociception_after	1.58082229
29	MP0008872_abnormal_physiological_respon	1.57467067
30	MP0003718_maternal_effect	1.56028929
31	MP0004885_abnormal_endolymph	1.55976389
32	MP0006276_abnormal_autonomic_nervous	1.52601509
33	MP0005551_abnormal_eye_electrophysiolog	1.52473260
34	MP0005379_endocrine/exocrine_gland_phen	1.50147074
35	MP0002160_abnormal_reproductive_system	1.49390077
36	MP0002277_abnormal_respiratory_mucosa	1.48329651
37	MP0002638_abnormal_pupillary_reflex	1.48085960
38	MP0001873_stomach_inflammation	1.46478950
39	MP0003123_paternal_imprinting	1.45067361
40	MP0004742_abnormal_vestibular_system	1.39322618
41	MP0005646_abnormal_pituitary_gland	1.37556301
42	MP0002733_abnormal_thermal_nociception	1.35119339
43	MP0000372_irregular_coat_pigmentation	1.34605694
44	MP0001984_abnormal_olfaction	1.34595921
45	MP0005389_reproductive_system_phenotype	1.32739047
46	MP0001986_abnormal_taste_sensitivity	1.31503379
47	MP0005394_taste/olfaction_phenotype	1.28265038
48	MP0005499_abnormal_olfactory_system	1.28265038
49	MP0001293_anophthalmia	1.27488259
50	MP0003880_abnormal_central_pattern	1.26878691
51	MP0009333_abnormal_splenocyte_physiolog	1.26832412
52	MP0002234_abnormal_pharynx_morphology	1.26478137
53	MP0001188_hyperpigmentation	1.25483028
54	MP0002095_abnormal_skin_pigmentation	1.24034644
55	MP0005360_urolithiasis	1.23962342
56	MP0001485_abnormal_pinna_reflex	1.23236723
57	MP0003878_abnormal_ear_physiology	1.22861490
58	MP0005377_hearing/vestibular/ear_phenot	1.22861490
59	MP0005075_abnormal_melanosome_morpholog	1.21829684
60	MP0003567_abnormal_fetal_cardiomyocyte	1.16810421
61	MP0002272_abnormal_nervous_system	1.13718715
62	MP0003186_abnormal_redox_activity	1.05322116
63	MP0001970_abnormal_pain_threshold	1.05115270
64	MP0002210_abnormal_sex_determination	1.04933040
65	MP0004043_abnormal_pH_regulation	1.03861305
66	MP0003195_calcinosis	1.01445820
67	MP0002557_abnormal_social/conspecific_i	1.00882411
68	MP0010386_abnormal_urinary_bladder	0.99586582
69	MP0003693_abnormal_embryo_hatching	0.98773020
70	MP0000631_abnormal_neuroendocrine_gland	0.96641869
71	MP0005253_abnormal_eye_physiology	0.89215896
72	MP0009745_abnormal_behavioral_response	0.86008249
73	MP0001919_abnormal_reproductive_system	0.85284940
74	MP0008775_abnormal_heart_ventricle	0.85125176
75	MP0004133_heterotaxia	0.84824454
76	MP0002067_abnormal_sensory_capabilities	0.84813223
77	MP0005174_abnormal_tail_pigmentation	0.81276093
78	MP0001929_abnormal_gametogenesis	0.80366642
79	MP0005332_abnormal_amino_acid	0.80120054
80	MP0000569_abnormal_digit_pigmentation	0.80109305
81	MP0002928_abnormal_bile_duct	0.79716089
82	MP0003283_abnormal_digestive_organ	0.79710589
83	MP0005195_abnormal_posterior_eye	0.78986093
84	MP0001486_abnormal_startle_reflex	0.77736201
85	MP0000049_abnormal_middle_ear	0.76638775
86	MP0002572_abnormal_emotion/affect_behav	0.75962344
87	MP0000778_abnormal_nervous_system	0.75581503
88	MP0000653_abnormal_sex_gland	0.75117502
89	MP0005386_behavior/neurological_phenoty	0.74519322
90	MP0004924_abnormal_behavior	0.74519322
91	MP0005085_abnormal_gallbladder_physiolo	0.73886674
92	MP0002693_abnormal_pancreas_physiology	0.73246792
93	MP0001764_abnormal_homeostasis	0.73049313
94	MP0003786_premature_aging	0.72742621
95	MP0001348_abnormal_lacrimal_gland	0.72504341
96	MP0001145_abnormal_male_reproductive	0.72375469
97	MP0003011_delayed_dark_adaptation	0.72302108
98	MP0003806_abnormal_nucleotide_metabolis	0.71218013
99	MP0000538_abnormal_urinary_bladder	0.70019633
100	MP0001324_abnormal_eye_pigmentation	0.69902391

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.74919792
2	Reticulocytopenia (HP:0001896)	4.35185173
3	Molar tooth sign on MRI (HP:0002419)	4.14987927
4	Abnormality of midbrain morphology (HP:0002418)	4.14987927
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.13276969
6	Progressive macrocephaly (HP:0004481)	4.07358322
7	Mitochondrial inheritance (HP:0001427)	4.02982120
8	Acute encephalopathy (HP:0006846)	3.99143751
9	Increased CSF lactate (HP:0002490)	3.71979519
10	Medial flaring of the eyebrow (HP:0010747)	3.38131322
11	Increased hepatocellular lipid droplets (HP:0006565)	3.16481919
12	Pancreatic fibrosis (HP:0100732)	3.14093475
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.09343513
14	Hepatocellular necrosis (HP:0001404)	3.08664298
15	Lipid accumulation in hepatocytes (HP:0006561)	3.07708292
16	Pancreatic cysts (HP:0001737)	3.04647413
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.03683424
18	Cerebral edema (HP:0002181)	2.98989500
19	Abolished electroretinogram (ERG) (HP:0000550)	2.89279560
20	Hepatic necrosis (HP:0002605)	2.89007874
21	Nephronophthisis (HP:0000090)	2.83543165
22	Abnormality of cells of the erythroid lineage (HP:0012130)	2.77435677
23	Congenital stationary night blindness (HP:0007642)	2.75341044
24	Colon cancer (HP:0003003)	2.72653076
25	Optic disc pallor (HP:0000543)	2.69688534
26	Hyperglycinemia (HP:0002154)	2.61333054
27	True hermaphroditism (HP:0010459)	2.60532937
28	Macrocytic anemia (HP:0001972)	2.55569891
29	3-Methylglutaconic aciduria (HP:0003535)	2.53914143
30	Congenital primary aphakia (HP:0007707)	2.53182662
31	Gait imbalance (HP:0002141)	2.50844959
32	Type II lissencephaly (HP:0007260)	2.49771981
33	Abnormality of macular pigmentation (HP:0008002)	2.49374020
34	Increased intramyocellular lipid droplets (HP:0012240)	2.46730156
35	Cutaneous melanoma (HP:0012056)	2.46637349
36	Increased serum lactate (HP:0002151)	2.46380508
37	Pendular nystagmus (HP:0012043)	2.45800664
38	Nephrogenic diabetes insipidus (HP:0009806)	2.40931398
39	Abnormality of the renal medulla (HP:0100957)	2.40604450
40	Methylmalonic aciduria (HP:0012120)	2.39597001
41	Absent thumb (HP:0009777)	2.34559695
42	Exertional dyspnea (HP:0002875)	2.33030160
43	Renal Fanconi syndrome (HP:0001994)	2.32813900
44	Abnormal hemoglobin (HP:0011902)	2.32542622
45	Lethargy (HP:0001254)	2.30051833
46	Pallor (HP:0000980)	2.29439872
47	Lactic acidosis (HP:0003128)	2.26785130
48	Constricted visual fields (HP:0001133)	2.25873088
49	Cerebellar dysplasia (HP:0007033)	2.24082925
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23088967
51	Abnormality of the labia minora (HP:0012880)	2.22288236
52	Abnormality of the renal cortex (HP:0011035)	2.21137723
53	Abnormal number of erythroid precursors (HP:0012131)	2.19560366
54	Respiratory failure (HP:0002878)	2.13168591
55	Dyschromatopsia (HP:0007641)	2.12366745
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11121800
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11121800
58	Central scotoma (HP:0000603)	2.09549360
59	Abnormality of DNA repair (HP:0003254)	2.09232949
60	Increased muscle lipid content (HP:0009058)	2.07666191
61	Increased IgM level (HP:0003496)	2.07116261
62	IgG deficiency (HP:0004315)	2.04428611
63	Decreased central vision (HP:0007663)	2.02295125
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01902964
65	Leukodystrophy (HP:0002415)	2.01404724
66	Abnormality of alanine metabolism (HP:0010916)	1.98751235
67	Hyperalaninemia (HP:0003348)	1.98751235
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98751235
69	Methylmalonic acidemia (HP:0002912)	1.96911742
70	Stenosis of the external auditory canal (HP:0000402)	1.96245206
71	Exercise intolerance (HP:0003546)	1.96098536
72	Microretrognathia (HP:0000308)	1.93939834
73	Asplenia (HP:0001746)	1.86409693
74	Cystic liver disease (HP:0006706)	1.85160922
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84376531
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81598779
77	Dicarboxylic aciduria (HP:0003215)	1.79679585
78	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.79679585
79	Glycosuria (HP:0003076)	1.77911143
80	Abnormality of urine glucose concentration (HP:0011016)	1.77911143
81	Attenuation of retinal blood vessels (HP:0007843)	1.77884290
82	Anencephaly (HP:0002323)	1.77130281
83	Abnormality of glycine metabolism (HP:0010895)	1.76307448
84	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76307448
85	Respiratory difficulties (HP:0002880)	1.76232301
86	Concave nail (HP:0001598)	1.74543244
87	Chronic hepatic failure (HP:0100626)	1.74191524
88	Vaginal atresia (HP:0000148)	1.72576433
89	Hypoplasia of the ulna (HP:0003022)	1.72038491
90	Genital tract atresia (HP:0001827)	1.71876905
91	Abnormality of renal resorption (HP:0011038)	1.71863313
92	Congenital hepatic fibrosis (HP:0002612)	1.70905681
93	Postaxial hand polydactyly (HP:0001162)	1.68849432
94	Renal cortical cysts (HP:0000803)	1.67791984
95	Stomatitis (HP:0010280)	1.67089660
96	Horseshoe kidney (HP:0000085)	1.66686060
97	Hypoplasia of the uterus (HP:0000013)	1.66578162
98	Abnormal drinking behavior (HP:0030082)	1.66442363
99	Polydipsia (HP:0001959)	1.66442363
100	Hypoproteinemia (HP:0003075)	1.65850379

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	3.81060122
2	STK16	3.56198586
3	FRK	3.15574013
4	VRK2	3.11230167
5	TXK	3.00146308
6	WNK4	2.71414314
7	NUAK1	2.56542412
8	ADRBK2	2.52257395
9	TAF1	2.50515924
10	ZAK	2.42353842
11	BCKDK	2.32041439
12	TGFBR1	2.07129188
13	WNK3	2.05742265
14	GRK1	2.04731859
15	TIE1	2.00360127
16	PINK1	1.82248310
17	CDK8	1.81532232
18	VRK1	1.79382596
19	PBK	1.78689846
20	MAP4K2	1.71605885
21	TRIM28	1.59541069
22	DYRK2	1.59170683
23	TLK1	1.58955168
24	TNIK	1.51969925
25	MAP4K1	1.51037407
26	CDK19	1.45920322
27	MAP3K4	1.29482386
28	PASK	1.11988244
29	EIF2AK1	1.11708853
30	SRPK1	1.01860738
31	MKNK1	1.01435884
32	KDR	1.01176051
33	NME1	1.00433112
34	NEK2	0.94667561
35	MKNK2	0.94378601
36	DAPK2	0.91745318
37	STK39	0.91677168
38	TAOK3	0.90690980
39	ACVR1B	0.89817567
40	PLK3	0.88280740
41	MUSK	0.88274183
42	FLT3	0.82138022
43	MAP2K7	0.81916057
44	KIT	0.77339708
45	PRKCQ	0.75870715
46	PAK3	0.72635915
47	WNK1	0.71671015
48	EIF2AK3	0.70933051
49	PRKG2	0.70100164
50	PLK1	0.69190407
51	MST4	0.67789011
52	CSNK1G3	0.66208898
53	PRKCG	0.64640710
54	EPHB2	0.64397829
55	NLK	0.63362688
56	CSNK1G2	0.62578562
57	CSNK1G1	0.61510130
58	IKBKB	0.60777417
59	RPS6KA6	0.59778212
60	LIMK1	0.59335179
61	CSNK2A2	0.58213679
62	EPHA4	0.57894290
63	INSRR	0.57398214
64	DYRK3	0.57274926
65	MAP3K11	0.55978001
66	ADRBK1	0.55349525
67	OXSR1	0.54212114
68	MAPK13	0.53659763
69	ITK	0.53609801
70	DAPK3	0.52578342
71	TEC	0.51722317
72	ATR	0.50868144
73	STK11	0.49841371
74	PLK4	0.49607705
75	CAMKK2	0.49519496
76	CSNK1A1	0.49137912
77	BCR	0.46928039
78	CDC7	0.45274808
79	CSNK2A1	0.45239662
80	MAPKAPK5	0.45076883
81	DAPK1	0.45002814
82	RPS6KC1	0.44787245
83	RPS6KL1	0.44787245
84	AURKA	0.44415331
85	RPS6KA5	0.43280125
86	PRKCH	0.42560241
87	PRKACA	0.42511145
88	RPS6KA4	0.42042414
89	PRKCE	0.40857341
90	TSSK6	0.40297699
91	PDK2	0.40142786
92	PRKCI	0.39042784
93	FES	0.36920922
94	TESK2	0.36347703
95	BUB1	0.36342396
96	CDK9	0.35322833
97	AURKB	0.34645586
98	ATM	0.32832863
99	MAP2K6	0.32497140
100	STK38L	0.32223601

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.04465233
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87357668
3	Proteasome_Homo sapiens_hsa03050	3.44555054
4	Parkinsons disease_Homo sapiens_hsa05012	3.20476355
5	RNA polymerase_Homo sapiens_hsa03020	2.68715760
6	Protein export_Homo sapiens_hsa03060	2.47486879
7	Huntingtons disease_Homo sapiens_hsa05016	2.23515206
8	Basal transcription factors_Homo sapiens_hsa03022	2.12363022
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05915717
10	Sulfur metabolism_Homo sapiens_hsa00920	1.96073032
11	Alzheimers disease_Homo sapiens_hsa05010	1.94550921
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84667537
13	RNA degradation_Homo sapiens_hsa03018	1.83772399
14	Mismatch repair_Homo sapiens_hsa03430	1.61374033
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.59832614
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58852090
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.58736195
18	Homologous recombination_Homo sapiens_hsa03440	1.56434474
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54060675
20	Base excision repair_Homo sapiens_hsa03410	1.53763299
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53665985
22	DNA replication_Homo sapiens_hsa03030	1.53113585
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.51868931
24	Phototransduction_Homo sapiens_hsa04744	1.49702387
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45464060
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45259739
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.43938176
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37344632
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.33301115
30	Sulfur relay system_Homo sapiens_hsa04122	1.26900281
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.25131014
32	Regulation of autophagy_Homo sapiens_hsa04140	1.23527240
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21992980
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.20046597
35	Allograft rejection_Homo sapiens_hsa05330	1.19531311
36	Folate biosynthesis_Homo sapiens_hsa00790	1.15496713
37	RNA transport_Homo sapiens_hsa03013	1.15132058
38	Purine metabolism_Homo sapiens_hsa00230	1.10625286
39	Asthma_Homo sapiens_hsa05310	1.08156717
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07889308
41	Propanoate metabolism_Homo sapiens_hsa00640	1.06963282
42	One carbon pool by folate_Homo sapiens_hsa00670	1.06961392
43	Peroxisome_Homo sapiens_hsa04146	1.06266024
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.06028468
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02163435
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01555445
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98371257
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97226782
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.96702821
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96372068
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.94752111
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92801384
53	Fatty acid elongation_Homo sapiens_hsa00062	0.90514874
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89329278
55	Spliceosome_Homo sapiens_hsa03040	0.86419177
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83574482
57	Nicotine addiction_Homo sapiens_hsa05033	0.81934601
58	Metabolic pathways_Homo sapiens_hsa01100	0.80840339
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78684842
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78572740
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77596991
62	Butanoate metabolism_Homo sapiens_hsa00650	0.75632893
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.70302026
64	Caffeine metabolism_Homo sapiens_hsa00232	0.68087642
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66763690
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.65635204
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65053085
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64259310
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.63382178
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.61389176
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57479106
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56885301
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55969098
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53525513
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53466236
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50618013
77	Fatty acid degradation_Homo sapiens_hsa00071	0.50169642
78	Olfactory transduction_Homo sapiens_hsa04740	0.49419438
79	Antigen processing and presentation_Homo sapiens_hsa04612	0.49216647
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49070904
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49019006
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47773764
83	Retinol metabolism_Homo sapiens_hsa00830	0.46968568
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45639149
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44689856
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.41715966
87	Taste transduction_Homo sapiens_hsa04742	0.40210855
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38964538
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38127786
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.37267738
91	Morphine addiction_Homo sapiens_hsa05032	0.35725775
92	Mineral absorption_Homo sapiens_hsa04978	0.34589399
93	Glutathione metabolism_Homo sapiens_hsa00480	0.33857691
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32872422
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32191237
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30733173
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30263549
98	Insulin secretion_Homo sapiens_hsa04911	0.29537183
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26733423
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26448366

RPSAP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »