RPSAP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)8.17743312
2ribosomal small subunit assembly (GO:0000028)6.93437619
3ribosomal small subunit biogenesis (GO:0042274)6.52970697
4viral transcription (GO:0019083)6.40176178
5negative regulation of muscle hypertrophy (GO:0014741)6.32245261
6translational termination (GO:0006415)6.07624967
7maturation of SSU-rRNA (GO:0030490)5.99577308
8skeletal muscle adaptation (GO:0043501)5.89684984
9striated muscle atrophy (GO:0014891)5.85654869
10translational elongation (GO:0006414)5.55915899
11muscle atrophy (GO:0014889)5.23772492
12skeletal muscle tissue regeneration (GO:0043403)5.23031128
13regulation of skeletal muscle contraction (GO:0014819)5.20862421
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.10790600
15protein targeting to ER (GO:0045047)5.08725391
16cotranslational protein targeting to membrane (GO:0006613)5.04219681
17chaperone-mediated protein transport (GO:0072321)4.99123923
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.95952004
19ATP synthesis coupled proton transport (GO:0015986)4.95952004
20actin-myosin filament sliding (GO:0033275)4.93589219
21muscle filament sliding (GO:0030049)4.93589219
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.85851256
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.81849754
24protein localization to endoplasmic reticulum (GO:0070972)4.79614211
25viral life cycle (GO:0019058)4.71660903
26cellular protein complex disassembly (GO:0043624)4.62478694
27response to muscle activity (GO:0014850)4.58931267
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.48715215
29protein neddylation (GO:0045116)4.30877072
30negative regulation of organelle assembly (GO:1902116)4.24797915
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22400069
32translational initiation (GO:0006413)4.17933799
33actin-mediated cell contraction (GO:0070252)3.96998407
34protein complex disassembly (GO:0043241)3.94514531
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.92855614
36macromolecular complex disassembly (GO:0032984)3.75876615
37translation (GO:0006412)3.71902009
38GTP biosynthetic process (GO:0006183)3.69826178
39protein complex biogenesis (GO:0070271)3.68745228
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.56271983
41NADH dehydrogenase complex assembly (GO:0010257)3.56271983
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56271983
43DNA deamination (GO:0045006)3.49713436
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47612981
45ribonucleoprotein complex biogenesis (GO:0022613)3.43974289
46cell proliferation in forebrain (GO:0021846)3.41109718
47cellular response to dexamethasone stimulus (GO:0071549)3.39647359
48protein targeting to membrane (GO:0006612)3.38930329
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.37318512
50cellular component biogenesis (GO:0044085)3.34337282
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.33188010
52mitochondrial respiratory chain complex assembly (GO:0033108)3.29644381
53ATP biosynthetic process (GO:0006754)3.27052933
54ribosomal large subunit biogenesis (GO:0042273)3.22947586
55electron transport chain (GO:0022900)3.21758241
56respiratory electron transport chain (GO:0022904)3.21674480
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.17324525
58UTP biosynthetic process (GO:0006228)3.17250062
59positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.14615560
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12229429
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12229429
62behavioral response to nicotine (GO:0035095)3.11710216
63response to activity (GO:0014823)3.11691386
64response to dexamethasone (GO:0071548)3.08048466
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07918951
66pattern specification involved in kidney development (GO:0061004)3.05816886
67negative regulation of skeletal muscle tissue development (GO:0048642)3.03202362
68mRNA catabolic process (GO:0006402)2.97825660
69nonmotile primary cilium assembly (GO:0035058)2.97743266
70protein K6-linked ubiquitination (GO:0085020)2.95010859
71somite development (GO:0061053)2.93553150
72ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91988441
73response to electrical stimulus (GO:0051602)2.88688131
74hypothalamus development (GO:0021854)2.87366158
75UTP metabolic process (GO:0046051)2.85080721
76DNA damage response, signal transduction resulting in transcription (GO:0042772)2.82369097
77rRNA processing (GO:0006364)2.79831603
78protein polyglutamylation (GO:0018095)2.77289774
79rRNA metabolic process (GO:0016072)2.71973840
80myoblast migration (GO:0051451)2.70687160
81genetic imprinting (GO:0071514)2.70158193
82dendritic spine morphogenesis (GO:0060997)2.68242080
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.68142761
84substrate-independent telencephalic tangential migration (GO:0021826)2.68142761
85mesonephros development (GO:0001823)2.61967599
86response to testosterone (GO:0033574)2.61113697
87guanosine-containing compound biosynthetic process (GO:1901070)2.60490636
88RNA catabolic process (GO:0006401)2.60199814
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56045834
90hydrogen ion transmembrane transport (GO:1902600)2.53807475
91water-soluble vitamin biosynthetic process (GO:0042364)2.53194914
92cytidine metabolic process (GO:0046087)2.52115162
93cytidine catabolic process (GO:0006216)2.52115162
94cytidine deamination (GO:0009972)2.52115162
95regulation of gene expression by genetic imprinting (GO:0006349)2.51402961
96negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51233284
97ribosome biogenesis (GO:0042254)2.49753325
98CTP metabolic process (GO:0046036)2.49235563
99CTP biosynthetic process (GO:0006241)2.49235563
100nucleoside triphosphate biosynthetic process (GO:0009142)2.43531957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46449427
2VDR_22108803_ChIP-Seq_LS180_Human4.88906069
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.70303120
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40454087
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.47162528
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78124693
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.62059836
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60193199
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56733943
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47869134
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42381372
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.41165210
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32176490
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.24159578
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10778688
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.03111672
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.96678986
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.90657018
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88372133
20YY1_21170310_ChIP-Seq_MESCs_Mouse1.73108120
21TTF2_22483619_ChIP-Seq_HELA_Human1.72249434
22XRN2_22483619_ChIP-Seq_HELA_Human1.68520277
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66938840
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66736394
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.66363266
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56731464
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.56461557
28VDR_23849224_ChIP-Seq_CD4+_Human1.50411919
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48986459
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.48465840
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46405442
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43928679
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43729089
34SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43600747
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42091293
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.40949812
37TP53_22573176_ChIP-Seq_HFKS_Human1.37609332
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37304616
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.35055981
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34634820
41REST_21632747_ChIP-Seq_MESCs_Mouse1.31176809
42GABP_19822575_ChIP-Seq_HepG2_Human1.28462255
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28073295
44FOXP1_21924763_ChIP-Seq_HESCs_Human1.27552239
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27363108
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27135777
47FOXP3_21729870_ChIP-Seq_TREG_Human1.25337939
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24286562
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.24137091
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23804899
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21971189
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.21040082
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19987991
54IRF1_19129219_ChIP-ChIP_H3396_Human1.19533040
55TAF15_26573619_Chip-Seq_HEK293_Human1.16577349
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16106530
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15444100
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13855801
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.12465070
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11752020
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11643625
62ERA_21632823_ChIP-Seq_H3396_Human1.10973317
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08892052
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08358870
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06016042
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05661030
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04724832
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04246427
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04246427
70MYC_18940864_ChIP-ChIP_HL60_Human1.04211849
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03126832
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02813046
73NANOG_20526341_ChIP-Seq_ESCs_Human1.00766401
74AR_21572438_ChIP-Seq_LNCaP_Human1.00130693
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00047566
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99546870
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98913916
78BP1_19119308_ChIP-ChIP_Hs578T_Human0.98618522
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.97621745
80SA1_27219007_Chip-Seq_Bcells_Human0.96760114
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96666124
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96513476
83MYC_19829295_ChIP-Seq_ESCs_Human0.95853381
84ZNF274_21170338_ChIP-Seq_K562_Hela0.94075045
85ELK1_19687146_ChIP-ChIP_HELA_Human0.93243088
86BCL6_27268052_Chip-Seq_Bcells_Human0.92990683
87NCOR_22424771_ChIP-Seq_293T_Human0.92961031
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.92116002
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92081204
90CTCF_27219007_Chip-Seq_Bcells_Human0.91833132
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91095610
92TAF2_19829295_ChIP-Seq_ESCs_Human0.90875354
93FUS_26573619_Chip-Seq_HEK293_Human0.90299401
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.90077120
95E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89005614
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88834896
97CTCF_20526341_ChIP-Seq_ESCs_Human0.87448582
98CIITA_25753668_ChIP-Seq_RAJI_Human0.86818150
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86596599
100P53_21459846_ChIP-Seq_SAOS-2_Human0.86103668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.07652198
2MP0004145_abnormal_muscle_electrophysio3.63368053
3MP0003123_paternal_imprinting3.03342330
4MP0003646_muscle_fatigue2.92808459
5MP0006292_abnormal_olfactory_placode2.77170897
6MP0002837_dystrophic_cardiac_calcinosis2.47622785
7MP0000747_muscle_weakness2.46846477
8MP0002089_abnormal_postnatal_growth/wei2.46842584
9MP0003787_abnormal_imprinting2.42605807
10MP0001348_abnormal_lacrimal_gland2.37016909
11MP0005646_abnormal_pituitary_gland2.36525859
12MP0010030_abnormal_orbit_morphology2.28480772
13MP0002638_abnormal_pupillary_reflex2.22336798
14MP0002653_abnormal_ependyma_morphology2.16820866
15MP0004142_abnormal_muscle_tone2.15980597
16MP0008789_abnormal_olfactory_epithelium2.10956871
17MP0001968_abnormal_touch/_nociception1.98967624
18MP0000049_abnormal_middle_ear1.96150364
19MP0002736_abnormal_nociception_after1.88905135
20MP0004885_abnormal_endolymph1.87867744
21MP0000749_muscle_degeneration1.86621420
22MP0002095_abnormal_skin_pigmentation1.83508424
23MP0001905_abnormal_dopamine_level1.76819677
24MP0004036_abnormal_muscle_relaxation1.65962588
25MP0003959_abnormal_lean_body1.60811673
26MP0000778_abnormal_nervous_system1.52661602
27MP0005083_abnormal_biliary_tract1.50598560
28MP0002876_abnormal_thyroid_physiology1.50075506
29MP0000631_abnormal_neuroendocrine_gland1.49045081
30MP0003121_genomic_imprinting1.46544619
31MP0002269_muscular_atrophy1.45722935
32MP0003122_maternal_imprinting1.43983487
33MP0000759_abnormal_skeletal_muscle1.42634510
34MP0001293_anophthalmia1.41897197
35MP0000372_irregular_coat_pigmentation1.41854569
36MP0003937_abnormal_limbs/digits/tail_de1.36179838
37MP0008877_abnormal_DNA_methylation1.33710617
38MP0001485_abnormal_pinna_reflex1.33536038
39MP0009745_abnormal_behavioral_response1.29934970
40MP0005499_abnormal_olfactory_system1.29144810
41MP0005394_taste/olfaction_phenotype1.29144810
42MP0002822_catalepsy1.28435799
43MP0002184_abnormal_innervation1.26120896
44MP0002733_abnormal_thermal_nociception1.24665392
45MP0005620_abnormal_muscle_contractility1.23729319
46MP0000750_abnormal_muscle_regeneration1.21567405
47MP0003878_abnormal_ear_physiology1.21081953
48MP0005377_hearing/vestibular/ear_phenot1.21081953
49MP0004270_analgesia1.17684856
50MP0003136_yellow_coat_color1.17031616
51MP0002106_abnormal_muscle_physiology1.15513999
52MP0002272_abnormal_nervous_system1.14734363
53MP0005084_abnormal_gallbladder_morpholo1.12691732
54MP0003938_abnormal_ear_development1.12493091
55MP0005423_abnormal_somatic_nervous1.11331211
56MP0008872_abnormal_physiological_respon1.10384159
57MP0001529_abnormal_vocalization1.09103779
58MP0002138_abnormal_hepatobiliary_system1.08265773
59MP0001970_abnormal_pain_threshold1.07712798
60MP0000566_synostosis1.06634263
61MP0002160_abnormal_reproductive_system1.05743670
62MP0006072_abnormal_retinal_apoptosis1.04568375
63MP0002557_abnormal_social/conspecific_i1.03741880
64MP0006276_abnormal_autonomic_nervous1.03024835
65MP0001440_abnormal_grooming_behavior1.03005762
66MP0001502_abnormal_circadian_rhythm1.02540862
67MP0008775_abnormal_heart_ventricle1.02138390
68MP0004133_heterotaxia1.01594473
69MP0000427_abnormal_hair_cycle1.00919802
70MP0004147_increased_porphyrin_level0.98778792
71MP0000026_abnormal_inner_ear0.98731106
72MP0002734_abnormal_mechanical_nocicepti0.97024813
73MP0002735_abnormal_chemical_nociception0.96296680
74MP0002108_abnormal_muscle_morphology0.93700395
75MP0002102_abnormal_ear_morphology0.93374372
76MP0000955_abnormal_spinal_cord0.89578563
77MP0004130_abnormal_muscle_cell0.88124514
78MP0002067_abnormal_sensory_capabilities0.87649099
79MP0009250_abnormal_appendicular_skeleto0.87354035
80MP0000230_abnormal_systemic_arterial0.87293680
81MP0005551_abnormal_eye_electrophysiolog0.86297529
82MP0004087_abnormal_muscle_fiber0.85334115
83MP0002938_white_spotting0.85148446
84MP0002752_abnormal_somatic_nervous0.83336657
85MP0005369_muscle_phenotype0.82973351
86MP0002277_abnormal_respiratory_mucosa0.82762964
87MP0008875_abnormal_xenobiotic_pharmacok0.82733605
88MP0003942_abnormal_urinary_system0.81944403
89MP0004742_abnormal_vestibular_system0.81268272
90MP0003879_abnormal_hair_cell0.81027259
91MP0003786_premature_aging0.80825920
92MP0002063_abnormal_learning/memory/cond0.79078691
93MP0003635_abnormal_synaptic_transmissio0.78989839
94MP0002572_abnormal_emotion/affect_behav0.77240478
95MP0005379_endocrine/exocrine_gland_phen0.76500696
96MP0001765_abnormal_ion_homeostasis0.76484004
97MP0003880_abnormal_central_pattern0.74438843
98MP0003936_abnormal_reproductive_system0.73981202
99MP0001963_abnormal_hearing_physiology0.73933320
100MP0002210_abnormal_sex_determination0.73629138

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)5.93138270
2Reticulocytopenia (HP:0001896)4.71885868
3Acute necrotizing encephalopathy (HP:0006965)4.12832180
4Absent phalangeal crease (HP:0006109)3.64564968
5Acute encephalopathy (HP:0006846)3.61361697
6Abnormal mitochondria in muscle tissue (HP:0008316)3.56798870
7Abnormality of cells of the erythroid lineage (HP:0012130)3.45072102
8Progressive macrocephaly (HP:0004481)3.44036345
9Mitochondrial inheritance (HP:0001427)3.29035872
10Distal arthrogryposis (HP:0005684)3.27937372
11Round ear (HP:0100830)3.20297547
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.15452327
13Abnormal finger flexion creases (HP:0006143)3.08913743
14Periorbital edema (HP:0100539)3.08313818
15Calcaneovalgus deformity (HP:0001848)3.07457053
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02141938
17Deformed tarsal bones (HP:0008119)3.01460826
18Facial edema (HP:0000282)2.96593340
19Stenosis of the external auditory canal (HP:0000402)2.92937322
20Abnormality of midbrain morphology (HP:0002418)2.91554377
21Molar tooth sign on MRI (HP:0002419)2.91554377
22Septo-optic dysplasia (HP:0100842)2.90791407
23Mask-like facies (HP:0000298)2.89582763
243-Methylglutaconic aciduria (HP:0003535)2.85888889
25Ulnar deviation of the wrist (HP:0003049)2.84494943
26Increased CSF lactate (HP:0002490)2.79013571
27Exercise-induced myalgia (HP:0003738)2.77139167
28Fibular aplasia (HP:0002990)2.75160908
29Pancreatic cysts (HP:0001737)2.72897999
30Pancreatic fibrosis (HP:0100732)2.71450207
31Asplenia (HP:0001746)2.67620647
32Nemaline bodies (HP:0003798)2.61598335
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.61150476
34Abnormal rod and cone electroretinograms (HP:0008323)2.60693975
35Hyperphosphatemia (HP:0002905)2.60618960
36True hermaphroditism (HP:0010459)2.59278924
37Macrocytic anemia (HP:0001972)2.54804449
38Nephronophthisis (HP:0000090)2.52038324
39Abnormal number of erythroid precursors (HP:0012131)2.41863042
40Hepatocellular necrosis (HP:0001404)2.40721542
41Optic disc pallor (HP:0000543)2.32380234
42Hyperthyroidism (HP:0000836)2.32367467
43Symphalangism affecting the phalanges of the hand (HP:0009773)2.27484728
44Cerebral edema (HP:0002181)2.25816309
45Pendular nystagmus (HP:0012043)2.25587869
46Hyperkalemia (HP:0002153)2.24532910
47Maternal diabetes (HP:0009800)2.24402889
48Agitation (HP:0000713)2.22856727
49Down-sloping shoulders (HP:0200021)2.16365387
50Congenital stationary night blindness (HP:0007642)2.15316306
51Decreased circulating renin level (HP:0003351)2.11906178
52Abnormality of the renal medulla (HP:0100957)2.11646418
53Abnormality of the proximal phalanges of the hand (HP:0009834)2.06672518
54Anencephaly (HP:0002323)2.04026821
55Hepatic necrosis (HP:0002605)2.03756574
56Muscle fiber inclusion bodies (HP:0100299)2.02859578
57Bile duct proliferation (HP:0001408)2.02569891
58Abnormal biliary tract physiology (HP:0012439)2.02569891
59Mesomelia (HP:0003027)2.02419917
60Pallor (HP:0000980)2.00567285
61Abnormality of DNA repair (HP:0003254)1.99833900
62Oligodactyly (hands) (HP:0001180)1.99216240
63Absent thumb (HP:0009777)1.97916760
64Hypoplasia of the ulna (HP:0003022)1.96521856
65Absent septum pellucidum (HP:0001331)1.96018547
66Hypoplastic pelvis (HP:0008839)1.95632099
67Oligomenorrhea (HP:0000876)1.94929424
68Abnormality of the phalanges of the 5th finger (HP:0004213)1.94757264
69Hypoplasia of the radius (HP:0002984)1.93663782
70Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93224494
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93157800
72Increased hepatocellular lipid droplets (HP:0006565)1.90671196
73Myotonia (HP:0002486)1.90217830
74Increased serum lactate (HP:0002151)1.88370809
75Medial flaring of the eyebrow (HP:0010747)1.87950375
76Synostosis of carpal bones (HP:0005048)1.87142827
77Lipid accumulation in hepatocytes (HP:0006561)1.86515453
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.86189480
79Sclerocornea (HP:0000647)1.85540908
80Abnormality of alanine metabolism (HP:0010916)1.83584179
81Hyperalaninemia (HP:0003348)1.83584179
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83584179
83Hypoproteinemia (HP:0003075)1.81839185
84Oligodactyly (HP:0012165)1.81199177
85Renal Fanconi syndrome (HP:0001994)1.79856615
86Myokymia (HP:0002411)1.79017519
87Abnormality of potassium homeostasis (HP:0011042)1.77987965
882-3 toe syndactyly (HP:0004691)1.75142481
89Rib fusion (HP:0000902)1.73896904
90Lactic acidosis (HP:0003128)1.72154758
91Optic nerve coloboma (HP:0000588)1.71327982
92Type II lissencephaly (HP:0007260)1.70536844
93Forearm undergrowth (HP:0009821)1.70487857
94Exercise intolerance (HP:0003546)1.70271020
95Myopathic facies (HP:0002058)1.69662838
96Adrenal hypoplasia (HP:0000835)1.67548089
97Enlarged penis (HP:0000040)1.67484761
98Aplasia/Hypoplasia of the ulna (HP:0006495)1.66559424
99Myoglobinuria (HP:0002913)1.66135215
100Abnormality of the renal collecting system (HP:0004742)1.65884960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.24894654
2PHKG23.70215054
3PHKG13.70215054
4STK163.47079289
5TIE13.13290464
6NME22.80086752
7CDK192.22446244
8DYRK22.21939059
9LIMK12.20520432
10OBSCN2.11710972
11MUSK2.03831608
12VRK22.03543276
13PINK12.00254964
14WNK11.94110322
15BCKDK1.92944158
16CAMK1D1.84167702
17MAP4K21.83769031
18TYRO31.83282308
19CASK1.79590029
20EPHB21.76698776
21ADRBK21.63616262
22PIK3CA1.60224308
23BMPR1B1.54658248
24NUAK11.53018952
25STK391.47899180
26CAMK1G1.37534733
27LRRK21.27923150
28MAPK131.17641634
29AURKA1.15789335
30SGK2231.13685132
31SGK4941.13685132
32FRK1.12393586
33CAMK11.07288880
34BRAF1.06684938
35TLK11.04302017
36TESK21.01300426
37CAMKK21.00961693
38MAP2K70.99395279
39TRIM280.99292117
40GRK10.98160389
41TXK0.97544064
42MAP3K120.95179102
43MAP3K110.94226063
44DYRK1B0.91784770
45PRKCG0.85356039
46MINK10.80541082
47IRAK10.77915307
48MAPKAPK30.77011628
49ZAK0.76672338
50PRKCI0.75910523
51CHEK20.74716214
52ABL20.74169451
53PDK20.72538241
54CAMK2G0.72430084
55ILK0.66988996
56CAMKK10.66442996
57CAMK40.65779219
58AKT30.65702177
59CSNK1G20.65325946
60RPS6KA60.62624583
61ARAF0.62411574
62DAPK30.62053404
63PAK60.61478598
64NTRK20.60102215
65TESK10.60088375
66OXSR10.59428524
67TAF10.58617909
68SGK20.56489292
69RPS6KL10.55376695
70RPS6KC10.55376695
71SGK10.55373032
72PRKACA0.54359665
73MARK10.53446530
74PIM20.53276689
75MAP3K40.53107307
76RPS6KA20.52352401
77SGK30.48985299
78CSNK1G10.48979605
79CCNB10.48650261
80PRKD30.48376513
81RPS6KA50.48145309
82INSRR0.46291038
83FGFR20.45905484
84PRKCH0.43874513
85GRK70.43579621
86LMTK20.43225121
87ATR0.42417588
88PRKCQ0.41269457
89STK110.40099594
90DAPK20.39709099
91VRK10.39661647
92DAPK10.39253976
93DMPK0.38582632
94CSNK2A20.38356038
95ADRBK10.38114252
96PIK3CG0.37276528
97CAMK2D0.37196342
98MOS0.36802519
99PRKG10.35415061
100CSNK1G30.35132551

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.56828117
2Oxidative phosphorylation_Homo sapiens_hsa001904.18270753
3Parkinsons disease_Homo sapiens_hsa050123.53735457
4Cardiac muscle contraction_Homo sapiens_hsa042603.00353087
5Alzheimers disease_Homo sapiens_hsa050102.68555000
6Huntingtons disease_Homo sapiens_hsa050162.60345447
7Proteasome_Homo sapiens_hsa030502.56245073
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24721567
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10787843
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95380789
11RNA polymerase_Homo sapiens_hsa030201.84528867
12Regulation of autophagy_Homo sapiens_hsa041401.69229851
13Tight junction_Homo sapiens_hsa045301.68297986
14Sulfur relay system_Homo sapiens_hsa041221.64097704
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63325846
16Folate biosynthesis_Homo sapiens_hsa007901.39932701
17Hedgehog signaling pathway_Homo sapiens_hsa043401.39916774
18Protein export_Homo sapiens_hsa030601.39067509
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38373975
20Basal transcription factors_Homo sapiens_hsa030221.37850373
21Basal cell carcinoma_Homo sapiens_hsa052171.34372280
22Insulin secretion_Homo sapiens_hsa049111.34238395
23RNA degradation_Homo sapiens_hsa030181.28312663
24Linoleic acid metabolism_Homo sapiens_hsa005911.27925938
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19594962
26Phototransduction_Homo sapiens_hsa047441.18544552
27Morphine addiction_Homo sapiens_hsa050321.13952158
28Nitrogen metabolism_Homo sapiens_hsa009101.12511813
29Fanconi anemia pathway_Homo sapiens_hsa034601.11798549
30Nucleotide excision repair_Homo sapiens_hsa034201.06427298
31Pyrimidine metabolism_Homo sapiens_hsa002401.03894302
32Homologous recombination_Homo sapiens_hsa034401.01913529
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01707048
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96885867
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.95665100
36Caffeine metabolism_Homo sapiens_hsa002320.90335693
37Salivary secretion_Homo sapiens_hsa049700.90005946
38Circadian entrainment_Homo sapiens_hsa047130.87539916
39Oxytocin signaling pathway_Homo sapiens_hsa049210.84368896
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82754126
41Dopaminergic synapse_Homo sapiens_hsa047280.81630257
42Purine metabolism_Homo sapiens_hsa002300.77827861
43Glutathione metabolism_Homo sapiens_hsa004800.76972347
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76187200
45Fat digestion and absorption_Homo sapiens_hsa049750.73722542
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73366646
47Peroxisome_Homo sapiens_hsa041460.73349006
48Spliceosome_Homo sapiens_hsa030400.72530994
49Nicotine addiction_Homo sapiens_hsa050330.71478551
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69312141
51Gastric acid secretion_Homo sapiens_hsa049710.68661809
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68135190
53RNA transport_Homo sapiens_hsa030130.68021114
54Wnt signaling pathway_Homo sapiens_hsa043100.67446429
55Chemical carcinogenesis_Homo sapiens_hsa052040.65768132
56Tryptophan metabolism_Homo sapiens_hsa003800.63696297
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62445737
58Calcium signaling pathway_Homo sapiens_hsa040200.62120580
59Ether lipid metabolism_Homo sapiens_hsa005650.61407149
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61355943
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60552924
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.59861718
63GABAergic synapse_Homo sapiens_hsa047270.59399689
64Mismatch repair_Homo sapiens_hsa034300.59358279
65Butanoate metabolism_Homo sapiens_hsa006500.58131746
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57827200
67One carbon pool by folate_Homo sapiens_hsa006700.57005709
68Metabolic pathways_Homo sapiens_hsa011000.56010045
69Collecting duct acid secretion_Homo sapiens_hsa049660.54346566
70Glucagon signaling pathway_Homo sapiens_hsa049220.54137493
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53989473
72Cholinergic synapse_Homo sapiens_hsa047250.52467589
73Synaptic vesicle cycle_Homo sapiens_hsa047210.52156951
74Renin secretion_Homo sapiens_hsa049240.51455686
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51438264
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.50898476
77Asthma_Homo sapiens_hsa053100.50243321
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49792383
79Olfactory transduction_Homo sapiens_hsa047400.49186081
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47718045
81Arachidonic acid metabolism_Homo sapiens_hsa005900.47192584
82Sulfur metabolism_Homo sapiens_hsa009200.47013825
83Serotonergic synapse_Homo sapiens_hsa047260.45116045
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43327803
85Steroid biosynthesis_Homo sapiens_hsa001000.43211972
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42593635
87Glutamatergic synapse_Homo sapiens_hsa047240.41690273
88Pancreatic secretion_Homo sapiens_hsa049720.38868590
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37697366
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37324530
91Hippo signaling pathway_Homo sapiens_hsa043900.36125253
92Long-term depression_Homo sapiens_hsa047300.35318411
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35012466
94Dilated cardiomyopathy_Homo sapiens_hsa054140.34872148
95DNA replication_Homo sapiens_hsa030300.34449381
96Axon guidance_Homo sapiens_hsa043600.33937916
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33542736
98Arginine biosynthesis_Homo sapiens_hsa002200.33237694
99Mineral absorption_Homo sapiens_hsa049780.31853782
100Arginine and proline metabolism_Homo sapiens_hsa003300.30974145

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