ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.51674479
2	response to pheromone (GO:0019236)	4.90227928
3	protein complex biogenesis (GO:0070271)	4.11246149
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.08497166
5	NADH dehydrogenase complex assembly (GO:0010257)	4.08497166
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.08497166
7	L-fucose catabolic process (GO:0042355)	4.05499780
8	fucose catabolic process (GO:0019317)	4.05499780
9	L-fucose metabolic process (GO:0042354)	4.05499780
10	detection of light stimulus involved in sensory perception (GO:0050962)	3.88540451
11	detection of light stimulus involved in visual perception (GO:0050908)	3.88540451
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.83116233
13	regulation of cilium movement (GO:0003352)	3.78594860
14	platelet dense granule organization (GO:0060155)	3.54678112
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53538500
16	DNA deamination (GO:0045006)	3.47570955
17	kynurenine metabolic process (GO:0070189)	3.44756424
18	respiratory chain complex IV assembly (GO:0008535)	3.37433542
19	cytochrome complex assembly (GO:0017004)	3.32796616
20	pyrimidine nucleobase catabolic process (GO:0006208)	3.30426297
21	indole-containing compound catabolic process (GO:0042436)	3.29160897
22	indolalkylamine catabolic process (GO:0046218)	3.29160897
23	tryptophan catabolic process (GO:0006569)	3.29160897
24	neuronal action potential (GO:0019228)	3.28293494
25	ATP synthesis coupled proton transport (GO:0015986)	3.26491268
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.26491268
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.24680764
28	indolalkylamine metabolic process (GO:0006586)	3.23617962
29	protein polyglutamylation (GO:0018095)	3.20232373
30	axoneme assembly (GO:0035082)	3.17323088
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15378919
32	ubiquinone biosynthetic process (GO:0006744)	3.13654136
33	synaptic transmission, cholinergic (GO:0007271)	3.09751054
34	nonmotile primary cilium assembly (GO:0035058)	3.04123822
35	regulation of action potential (GO:0098900)	3.01312050
36	primary amino compound metabolic process (GO:1901160)	3.00298218
37	regulation of microtubule-based movement (GO:0060632)	2.97615535
38	ubiquinone metabolic process (GO:0006743)	2.96796551
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94208227
40	auditory behavior (GO:0031223)	2.94100781
41	cAMP catabolic process (GO:0006198)	2.91697934
42	mechanosensory behavior (GO:0007638)	2.90572056
43	protein neddylation (GO:0045116)	2.89666329
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88690780
45	indole-containing compound metabolic process (GO:0042430)	2.88253897
46	gamma-aminobutyric acid transport (GO:0015812)	2.86460744
47	membrane depolarization during action potential (GO:0086010)	2.86095540
48	tryptophan metabolic process (GO:0006568)	2.85322001
49	serotonin metabolic process (GO:0042428)	2.84963559
50	parturition (GO:0007567)	2.84688759
51	alanine transport (GO:0032328)	2.84443211
52	glycerophospholipid catabolic process (GO:0046475)	2.83325614
53	negative regulation of mast cell activation (GO:0033004)	2.82260986
54	epithelial cilium movement (GO:0003351)	2.81212386
55	nucleobase catabolic process (GO:0046113)	2.81080913
56	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.77862556
57	transmission of nerve impulse (GO:0019226)	2.75154255
58	protein-cofactor linkage (GO:0018065)	2.74385171
59	somite rostral/caudal axis specification (GO:0032525)	2.74157417
60	regulation of meiosis I (GO:0060631)	2.73199449
61	reflex (GO:0060004)	2.72095752
62	somite development (GO:0061053)	2.72017098
63	cyclic nucleotide catabolic process (GO:0009214)	2.71433324
64	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.71101340
65	behavioral response to ethanol (GO:0048149)	2.68713625
66	cell proliferation in forebrain (GO:0021846)	2.68449984
67	photoreceptor cell maintenance (GO:0045494)	2.64924226
68	piRNA metabolic process (GO:0034587)	2.59629545
69	reciprocal meiotic recombination (GO:0007131)	2.58416187
70	reciprocal DNA recombination (GO:0035825)	2.58416187
71	head development (GO:0060322)	2.57997414
72	negative regulation of macrophage differentiation (GO:0045650)	2.57644547
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.57155943
74	maturation of SSU-rRNA (GO:0030490)	2.57025520
75	positive regulation of prostaglandin secretion (GO:0032308)	2.54346828
76	base-excision repair, AP site formation (GO:0006285)	2.52773081
77	male meiosis I (GO:0007141)	2.52667569
78	neuronal action potential propagation (GO:0019227)	2.51903632
79	dopamine transport (GO:0015872)	2.50858207
80	pseudouridine synthesis (GO:0001522)	2.49193556
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.48965110
82	neural tube formation (GO:0001841)	2.48739727
83	C4-dicarboxylate transport (GO:0015740)	2.48005560
84	positive regulation of fatty acid transport (GO:2000193)	2.46603738
85	electron transport chain (GO:0022900)	2.46583954
86	cilium morphogenesis (GO:0060271)	2.45210466
87	quinone biosynthetic process (GO:1901663)	2.41558590
88	positive regulation of action potential (GO:0045760)	2.40044509
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.39988147
90	negative regulation of response to food (GO:0032096)	2.39216902
91	negative regulation of appetite (GO:0032099)	2.39216902
92	proline transport (GO:0015824)	2.39142690
93	nephron epithelium morphogenesis (GO:0072088)	2.39077839
94	nephron tubule morphogenesis (GO:0072078)	2.39077839
95	cornea development in camera-type eye (GO:0061303)	2.38843023
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.38584010
97	cellular response to ATP (GO:0071318)	2.38502435
98	negative regulation of telomere maintenance (GO:0032205)	2.37996440
99	cellular biogenic amine catabolic process (GO:0042402)	2.37036095
100	amine catabolic process (GO:0009310)	2.37036095

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.26467897
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.11398321
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.58998815
4	VDR_22108803_ChIP-Seq_LS180_Human	2.85156405
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.76964827
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.63459386
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42774908
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.41493054
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34764224
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.28880135
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.28220480
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.26304393
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23680934
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04928579
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02782561
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.99114794
17	FUS_26573619_Chip-Seq_HEK293_Human	1.98702060
18	EWS_26573619_Chip-Seq_HEK293_Human	1.92402234
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89860555
20	P300_19829295_ChIP-Seq_ESCs_Human	1.89834409
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.87162794
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80561520
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73083651
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.71886307
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.69737972
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64659961
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63272101
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63077808
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61207454
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.56973637
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55405601
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.55003376
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54752449
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.52539829
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51244675
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.42707010
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39569060
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39350828
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38124833
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.36222505
41	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.35685092
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33533572
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33533572
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33177676
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32897373
46	AR_25329375_ChIP-Seq_VCAP_Human	1.32263305
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30661320
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29063026
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27957875
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27758635
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26561386
52	STAT3_23295773_ChIP-Seq_U87_Human	1.24984729
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.24856961
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23700904
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23700904
56	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22628059
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22107978
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.22107978
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.20887688
60	TCF4_23295773_ChIP-Seq_U87_Human	1.19944560
61	NCOR_22424771_ChIP-Seq_293T_Human	1.16941062
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16838899
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15750896
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15439939
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14531062
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.13738985
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12755501
68	AR_20517297_ChIP-Seq_VCAP_Human	1.12592895
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12551771
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12337401
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12175337
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11740063
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10877196
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10806092
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10440345
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10440345
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10223059
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10122887
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10026242
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08740467
81	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07673527
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.07083781
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06108835
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05856852
85	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05740280
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05671023
87	ERA_21632823_ChIP-Seq_H3396_Human	1.04992127
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02705448
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01337338
90	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.00603615
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00172680
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.99245232
93	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.98229418
94	VDR_23849224_ChIP-Seq_CD4+_Human	0.98084791
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98063034
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96148706
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96031258
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94667583
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94093853
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93687299

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.57930253
2	MP0005645_abnormal_hypothalamus_physiol	2.57970407
3	MP0005551_abnormal_eye_electrophysiolog	2.41089690
4	MP0001986_abnormal_taste_sensitivity	2.37398295
5	MP0002102_abnormal_ear_morphology	2.26912226
6	MP0009379_abnormal_foot_pigmentation	2.26504078
7	MP0001485_abnormal_pinna_reflex	2.25306427
8	MP0001529_abnormal_vocalization	2.20890991
9	MP0001968_abnormal_touch/_nociception	2.20238788
10	MP0000569_abnormal_digit_pigmentation	2.07518625
11	MP0004133_heterotaxia	2.06906686
12	MP0006072_abnormal_retinal_apoptosis	2.05644731
13	MP0008877_abnormal_DNA_methylation	2.05034592
14	MP0005084_abnormal_gallbladder_morpholo	2.04969245
15	MP0003880_abnormal_central_pattern	2.02023090
16	MP0003195_calcinosis	1.97534601
17	MP0008872_abnormal_physiological_respon	1.97322437
18	MP0004885_abnormal_endolymph	1.92628355
19	MP0003646_muscle_fatigue	1.91484303
20	MP0005646_abnormal_pituitary_gland	1.89213304
21	MP0004742_abnormal_vestibular_system	1.85728504
22	MP0002837_dystrophic_cardiac_calcinosis	1.80579128
23	MP0003011_delayed_dark_adaptation	1.80486731
24	MP0002736_abnormal_nociception_after	1.80022612
25	MP0002638_abnormal_pupillary_reflex	1.79390379
26	MP0008875_abnormal_xenobiotic_pharmacok	1.76724329
27	MP0003136_yellow_coat_color	1.74522565
28	MP0009046_muscle_twitch	1.74451815
29	MP0002876_abnormal_thyroid_physiology	1.72220398
30	MP0009745_abnormal_behavioral_response	1.70610410
31	MP0002938_white_spotting	1.70144485
32	MP0004142_abnormal_muscle_tone	1.67621938
33	MP0004145_abnormal_muscle_electrophysio	1.61658763
34	MP0002735_abnormal_chemical_nociception	1.61349220
35	MP0005253_abnormal_eye_physiology	1.58291639
36	MP0003283_abnormal_digestive_organ	1.55273805
37	MP0002272_abnormal_nervous_system	1.50976998
38	MP0008789_abnormal_olfactory_epithelium	1.50024866
39	MP0000631_abnormal_neuroendocrine_gland	1.49568819
40	MP0002160_abnormal_reproductive_system	1.47762790
41	MP0006276_abnormal_autonomic_nervous	1.46811140
42	MP0001486_abnormal_startle_reflex	1.44399020
43	MP0000566_synostosis	1.43852249
44	MP0002653_abnormal_ependyma_morphology	1.42558128
45	MP0005389_reproductive_system_phenotype	1.40174470
46	MP0002733_abnormal_thermal_nociception	1.39531064
47	MP0002064_seizures	1.36644472
48	MP0002067_abnormal_sensory_capabilities	1.34261082
49	MP0001905_abnormal_dopamine_level	1.30958417
50	MP0002572_abnormal_emotion/affect_behav	1.30395556
51	MP0001970_abnormal_pain_threshold	1.26412922
52	MP0002557_abnormal_social/conspecific_i	1.22723436
53	MP0004043_abnormal_pH_regulation	1.19680012
54	MP0002277_abnormal_respiratory_mucosa	1.19447393
55	MP0000372_irregular_coat_pigmentation	1.19337330
56	MP0000778_abnormal_nervous_system	1.18684675
57	MP0000026_abnormal_inner_ear	1.17931935
58	MP0005195_abnormal_posterior_eye	1.14974018
59	MP0002095_abnormal_skin_pigmentation	1.14314703
60	MP0003787_abnormal_imprinting	1.13124774
61	MP0002184_abnormal_innervation	1.12481071
62	MP0005174_abnormal_tail_pigmentation	1.11662365
63	MP0005386_behavior/neurological_phenoty	1.11569459
64	MP0004924_abnormal_behavior	1.11569459
65	MP0003635_abnormal_synaptic_transmissio	1.10622085
66	MP0001984_abnormal_olfaction	1.10545580
67	MP0002752_abnormal_somatic_nervous	1.10219091
68	MP0004147_increased_porphyrin_level	1.08842919
69	MP0002734_abnormal_mechanical_nocicepti	1.07651327
70	MP0001919_abnormal_reproductive_system	1.06364402
71	MP0001501_abnormal_sleep_pattern	1.05884766
72	MP0002751_abnormal_autonomic_nervous	1.02353563
73	MP0002063_abnormal_learning/memory/cond	1.02232762
74	MP0005410_abnormal_fertilization	1.01502269
75	MP0001963_abnormal_hearing_physiology	1.00287277
76	MP0000049_abnormal_middle_ear	0.97940438
77	MP0003122_maternal_imprinting	0.96728846
78	MP0000427_abnormal_hair_cycle	0.95863925
79	MP0003121_genomic_imprinting	0.95093614
80	MP0005365_abnormal_bile_salt	0.94379311
81	MP0008775_abnormal_heart_ventricle	0.93934899
82	MP0003567_abnormal_fetal_cardiomyocyte	0.93545645
83	MP0010386_abnormal_urinary_bladder	0.93235847
84	MP0005499_abnormal_olfactory_system	0.90915837
85	MP0005394_taste/olfaction_phenotype	0.90915837
86	MP0002210_abnormal_sex_determination	0.89384051
87	MP0009764_decreased_sensitivity_to	0.87638498
88	MP0003698_abnormal_male_reproductive	0.86521091
89	MP0001929_abnormal_gametogenesis	0.86098155
90	MP0003937_abnormal_limbs/digits/tail_de	0.85591302
91	MP0002138_abnormal_hepatobiliary_system	0.84898819
92	MP0005423_abnormal_somatic_nervous	0.84302031
93	MP0002234_abnormal_pharynx_morphology	0.83354107
94	MP0003938_abnormal_ear_development	0.83045948
95	MP0001293_anophthalmia	0.81705286
96	MP0003119_abnormal_digestive_system	0.80795949
97	MP0002882_abnormal_neuron_morphology	0.79870567
98	MP0008995_early_reproductive_senescence	0.78785786
99	MP0000955_abnormal_spinal_cord	0.77819329
100	MP0002928_abnormal_bile_duct	0.77808379

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.47185686
2	Type II lissencephaly (HP:0007260)	4.46016647
3	Molar tooth sign on MRI (HP:0002419)	3.81370045
4	Abnormality of midbrain morphology (HP:0002418)	3.81370045
5	Pancreatic fibrosis (HP:0100732)	3.76328962
6	Pancreatic cysts (HP:0001737)	3.74676916
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.63432149
8	True hermaphroditism (HP:0010459)	3.50176759
9	Cerebellar dysplasia (HP:0007033)	3.43822643
10	Nephronophthisis (HP:0000090)	3.39606514
11	Abnormality of alanine metabolism (HP:0010916)	3.22125558
12	Hyperalaninemia (HP:0003348)	3.22125558
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.22125558
14	Abnormality of the renal cortex (HP:0011035)	2.96005865
15	Abnormality of the renal medulla (HP:0100957)	2.92761651
16	Hypoplasia of the fovea (HP:0007750)	2.81058339
17	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.81058339
18	Pendular nystagmus (HP:0012043)	2.79517938
19	Acute necrotizing encephalopathy (HP:0006965)	2.78118894
20	Medial flaring of the eyebrow (HP:0010747)	2.77710387
21	Congenital, generalized hypertrichosis (HP:0004540)	2.77348466
22	Severe visual impairment (HP:0001141)	2.70614231
23	Renal cortical cysts (HP:0000803)	2.69480172
24	Hyperventilation (HP:0002883)	2.65333549
25	Mitochondrial inheritance (HP:0001427)	2.64845342
26	Abnormal drinking behavior (HP:0030082)	2.59677772
27	Polydipsia (HP:0001959)	2.59677772
28	Optic nerve hypoplasia (HP:0000609)	2.54042024
29	Broad-based gait (HP:0002136)	2.50958052
30	Hypoplasia of the pons (HP:0012110)	2.50937124
31	Progressive macrocephaly (HP:0004481)	2.48339651
32	Lissencephaly (HP:0001339)	2.44930435
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.43237840
34	Abnormality of the pons (HP:0007361)	2.40055947
35	Increased CSF lactate (HP:0002490)	2.39812066
36	Acute encephalopathy (HP:0006846)	2.37756759
37	Abnormality of macular pigmentation (HP:0008002)	2.35563881
38	Abnormality of the fovea (HP:0000493)	2.34207788
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.32796565
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31501989
41	Severe muscular hypotonia (HP:0006829)	2.29972183
42	3-Methylglutaconic aciduria (HP:0003535)	2.28078025
43	Attenuation of retinal blood vessels (HP:0007843)	2.26929688
44	Decreased central vision (HP:0007663)	2.26392235
45	Decreased circulating renin level (HP:0003351)	2.25922290
46	Tubular atrophy (HP:0000092)	2.23324122
47	Cystic liver disease (HP:0006706)	2.21747103
48	Inability to walk (HP:0002540)	2.20744572
49	Reticulocytopenia (HP:0001896)	2.17177431
50	Increased hepatocellular lipid droplets (HP:0006565)	2.16995641
51	Abolished electroretinogram (ERG) (HP:0000550)	2.16237118
52	Abnormal number of erythroid precursors (HP:0012131)	2.15586582
53	Congenital hepatic fibrosis (HP:0002612)	2.14979692
54	Stomach cancer (HP:0012126)	2.14890794
55	Lipid accumulation in hepatocytes (HP:0006561)	2.13665629
56	Gait imbalance (HP:0002141)	2.10712609
57	Optic disc pallor (HP:0000543)	2.10431726
58	Sclerocornea (HP:0000647)	2.08594993
59	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07022789
60	Hypomagnesemia (HP:0002917)	2.03003727
61	Rib fusion (HP:0000902)	2.02092441
62	Patellar aplasia (HP:0006443)	2.01363554
63	Hepatic necrosis (HP:0002605)	1.98855712
64	Congenital primary aphakia (HP:0007707)	1.98251488
65	Hepatocellular necrosis (HP:0001404)	1.98054180
66	Abnormality of cells of the erythroid lineage (HP:0012130)	1.97657356
67	Anencephaly (HP:0002323)	1.97418653
68	Bilateral microphthalmos (HP:0007633)	1.94704115
69	Aplasia/Hypoplasia of the patella (HP:0006498)	1.94298809
70	Retinal dysplasia (HP:0007973)	1.91985890
71	Polyuria (HP:0000103)	1.91333280
72	Chronic hepatic failure (HP:0100626)	1.91047986
73	Septo-optic dysplasia (HP:0100842)	1.87341846
74	Increased serum lactate (HP:0002151)	1.85859036
75	Amelogenesis imperfecta (HP:0000705)	1.85746242
76	Pachygyria (HP:0001302)	1.85440750
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84685197
78	Furrowed tongue (HP:0000221)	1.83762522
79	Postaxial foot polydactyly (HP:0001830)	1.83503351
80	Short tibia (HP:0005736)	1.82905364
81	Tachypnea (HP:0002789)	1.82686317
82	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.82595765
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80270571
84	Absent/shortened dynein arms (HP:0200106)	1.80270571
85	Progressive inability to walk (HP:0002505)	1.80208856
86	Nephrogenic diabetes insipidus (HP:0009806)	1.79327494
87	Hyperglycinemia (HP:0002154)	1.78427674
88	Drooling (HP:0002307)	1.77949050
89	Ketosis (HP:0001946)	1.77665905
90	Increased corneal curvature (HP:0100692)	1.75642625
91	Keratoconus (HP:0000563)	1.75642625
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.74366511
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74366511
94	Anophthalmia (HP:0000528)	1.73819266
95	Intestinal atresia (HP:0011100)	1.73338816
96	Male pseudohermaphroditism (HP:0000037)	1.72987331
97	Colon cancer (HP:0003003)	1.71111471
98	Genital tract atresia (HP:0001827)	1.71090058
99	Oligodactyly (hands) (HP:0001180)	1.70808603
100	Glycosuria (HP:0003076)	1.70597045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.11283906
2	FRK	3.77152705
3	GRK1	3.42453811
4	WNK3	3.40117111
5	TLK1	3.38966368
6	ADRBK2	3.08217268
7	ZAK	3.05288587
8	BMPR1B	2.83839001
9	PNCK	2.69655747
10	WNK4	2.65734206
11	MAP3K4	2.61921718
12	CASK	2.53460568
13	MAP2K7	2.40677242
14	MAP4K2	2.39738747
15	TAOK3	1.85988910
16	PINK1	1.75220065
17	DAPK2	1.75023357
18	MAPK13	1.73056800
19	SIK2	1.72343512
20	NUAK1	1.53972863
21	VRK1	1.45521877
22	MARK1	1.38717530
23	DYRK2	1.37461767
24	NEK2	1.27173419
25	CAMKK2	1.26846747
26	PAK3	1.25329461
27	ACVR1B	1.25042647
28	TNIK	1.14150237
29	NTRK2	1.09354288
30	MAPK15	1.08886792
31	NTRK3	1.07032873
32	MAP2K4	0.99782990
33	TIE1	0.98960687
34	BCKDK	0.97390937
35	ADRBK1	0.95008088
36	CSNK1G1	0.93962481
37	OXSR1	0.92145440
38	PRKCG	0.91557662
39	TXK	0.90384601
40	STK39	0.85601831
41	CSNK1G2	0.81123266
42	MKNK2	0.81115319
43	CSNK1G3	0.79630106
44	PIK3CA	0.77966508
45	PTK2B	0.77501487
46	TGFBR1	0.75760396
47	CDK19	0.75055303
48	PRKCE	0.75027395
49	RPS6KA5	0.73442545
50	PKN1	0.71876740
51	CSNK1A1L	0.69394056
52	CAMK1	0.58347575
53	BRSK2	0.57576668
54	CAMK1G	0.57053411
55	PRKACA	0.53671850
56	NME1	0.52991240
57	MET	0.52058715
58	CHUK	0.51890373
59	OBSCN	0.51696389
60	STK16	0.51435872
61	ABL2	0.48262978
62	WNK1	0.47618172
63	MAPKAPK5	0.47266032
64	PRKCQ	0.46626963
65	BLK	0.46059961
66	PHKG2	0.45929555
67	PHKG1	0.45929555
68	MUSK	0.45897899
69	CSNK1A1	0.44612202
70	BCR	0.42400936
71	CAMK2A	0.41467090
72	WEE1	0.40829016
73	MKNK1	0.40722496
74	IKBKB	0.39771660
75	VRK2	0.38938056
76	PRKD3	0.38299319
77	CDC7	0.38034106
78	PLK4	0.37417342
79	CAMKK1	0.36871774
80	PLK3	0.36287901
81	PRKCA	0.35384983
82	PLK1	0.34422761
83	STK11	0.33963718
84	DYRK1A	0.33327814
85	ATR	0.31596384
86	MAPKAPK3	0.31574194
87	TYRO3	0.31194872
88	STK4	0.30773886
89	PLK2	0.29231507
90	CSNK1D	0.28047610
91	EPHA4	0.27968749
92	BRAF	0.27463498
93	KDR	0.27440940
94	CSNK1E	0.27068314
95	EPHB2	0.26022123
96	SGK223	0.25613401
97	SGK494	0.25613401
98	SGK2	0.25360893
99	PRKCI	0.24802787
100	MAP2K6	0.23583431

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06070312
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.90053338
3	Phototransduction_Homo sapiens_hsa04744	2.85470762
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.67014052
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.64453983
6	Parkinsons disease_Homo sapiens_hsa05012	2.48669768
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46015280
8	Ribosome_Homo sapiens_hsa03010	2.45478321
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.33238728
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06041172
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.04423298
12	Homologous recombination_Homo sapiens_hsa03440	1.95747474
13	RNA polymerase_Homo sapiens_hsa03020	1.92975754
14	Nicotine addiction_Homo sapiens_hsa05033	1.90100784
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88629753
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80877946
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.78550690
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75001003
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73987270
20	Butanoate metabolism_Homo sapiens_hsa00650	1.71264968
21	Huntingtons disease_Homo sapiens_hsa05016	1.68115628
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.67755847
23	Alzheimers disease_Homo sapiens_hsa05010	1.66275557
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59587149
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57875798
26	Protein export_Homo sapiens_hsa03060	1.57184748
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48885769
28	Regulation of autophagy_Homo sapiens_hsa04140	1.44263634
29	Proteasome_Homo sapiens_hsa03050	1.41664919
30	Caffeine metabolism_Homo sapiens_hsa00232	1.39685694
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.37080960
32	Morphine addiction_Homo sapiens_hsa05032	1.34647563
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.22111328
34	Olfactory transduction_Homo sapiens_hsa04740	1.18869118
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17880998
36	Basal transcription factors_Homo sapiens_hsa03022	1.17230955
37	Peroxisome_Homo sapiens_hsa04146	1.16049369
38	Insulin secretion_Homo sapiens_hsa04911	1.13579404
39	Taste transduction_Homo sapiens_hsa04742	1.12328639
40	RNA degradation_Homo sapiens_hsa03018	1.10295427
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07309592
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05064012
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00999652
44	GABAergic synapse_Homo sapiens_hsa04727	0.96431049
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91920365
46	Serotonergic synapse_Homo sapiens_hsa04726	0.90862241
47	Asthma_Homo sapiens_hsa05310	0.89741210
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89258423
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89166666
50	Propanoate metabolism_Homo sapiens_hsa00640	0.86281206
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83482936
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82405012
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.81639451
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81367317
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.81259405
56	Purine metabolism_Homo sapiens_hsa00230	0.80936499
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80470890
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79876121
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78948124
60	Circadian entrainment_Homo sapiens_hsa04713	0.77634071
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76705511
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.76330656
63	Retinol metabolism_Homo sapiens_hsa00830	0.73485265
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72601547
65	ABC transporters_Homo sapiens_hsa02010	0.64510239
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.63225209
67	One carbon pool by folate_Homo sapiens_hsa00670	0.61977325
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61351426
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60722216
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60040700
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.59243165
72	Metabolic pathways_Homo sapiens_hsa01100	0.59226023
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56798559
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56305519
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55914449
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54399029
77	Sulfur relay system_Homo sapiens_hsa04122	0.53822573
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52337480
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51942419
80	Salivary secretion_Homo sapiens_hsa04970	0.50643206
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50327604
82	Cholinergic synapse_Homo sapiens_hsa04725	0.49736694
83	Base excision repair_Homo sapiens_hsa03410	0.47265938
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46865107
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46472131
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46451230
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45786312
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.44688565
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43612540
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42488021
91	Long-term depression_Homo sapiens_hsa04730	0.40801603
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40404648
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39172647
94	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38588049
95	Cocaine addiction_Homo sapiens_hsa05030	0.37657087
96	Alcoholism_Homo sapiens_hsa05034	0.36996468
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36245883
98	Amphetamine addiction_Homo sapiens_hsa05031	0.35063464
99	Axon guidance_Homo sapiens_hsa04360	0.34961223
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.34714097

RPSAP36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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