RPSAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.65917761
2ribosomal small subunit biogenesis (GO:0042274)6.60700988
3viral transcription (GO:0019083)6.52517994
4translational termination (GO:0006415)6.27058296
5DNA deamination (GO:0045006)5.98798923
6maturation of SSU-rRNA (GO:0030490)5.90846743
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.70166663
8cotranslational protein targeting to membrane (GO:0006613)5.64236390
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.62583286
10protein targeting to ER (GO:0045047)5.59410484
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.54698521
12ATP synthesis coupled proton transport (GO:0015986)5.54698521
13translational elongation (GO:0006414)5.54105952
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.34949788
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.27048356
16protein localization to endoplasmic reticulum (GO:0070972)5.25084299
17establishment of protein localization to mitochondrial membrane (GO:0090151)5.16430175
18protein neddylation (GO:0045116)4.82277780
19cellular protein complex disassembly (GO:0043624)4.74498914
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.65515840
21viral life cycle (GO:0019058)4.65393453
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57074719
23translational initiation (GO:0006413)4.52624601
24chaperone-mediated protein transport (GO:0072321)4.44608671
25translation (GO:0006412)4.28861192
26respiratory electron transport chain (GO:0022904)4.15335097
27behavioral response to nicotine (GO:0035095)4.13834370
28protein complex biogenesis (GO:0070271)4.13463106
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.11204189
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.11204189
31electron transport chain (GO:0022900)4.10724831
32protein complex disassembly (GO:0043241)3.96120493
33ncRNA 3-end processing (GO:0043628)3.90928307
34ribosomal large subunit biogenesis (GO:0042273)3.90124160
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.81746774
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78257315
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78201267
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.78201267
39NADH dehydrogenase complex assembly (GO:0010257)3.78201267
40macromolecular complex disassembly (GO:0032984)3.75743784
41water-soluble vitamin biosynthetic process (GO:0042364)3.74704956
42mitochondrial respiratory chain complex assembly (GO:0033108)3.74300955
43protein targeting to membrane (GO:0006612)3.67492696
44ribonucleoprotein complex biogenesis (GO:0022613)3.65924009
45cytidine metabolic process (GO:0046087)3.64437931
46cytidine catabolic process (GO:0006216)3.64437931
47cytidine deamination (GO:0009972)3.64437931
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.59934216
49cellular component biogenesis (GO:0044085)3.58112178
50GTP biosynthetic process (GO:0006183)3.43471746
51respiratory chain complex IV assembly (GO:0008535)3.43183463
52mRNA catabolic process (GO:0006402)3.38588404
53cytochrome complex assembly (GO:0017004)3.29207536
54response to pheromone (GO:0019236)3.22539499
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21149685
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20219446
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.14747050
58termination of RNA polymerase III transcription (GO:0006386)3.14747050
59ATP biosynthetic process (GO:0006754)3.14100613
60RNA catabolic process (GO:0006401)3.13098458
61rRNA modification (GO:0000154)3.08232085
62pyrimidine ribonucleoside catabolic process (GO:0046133)3.05470874
63rRNA processing (GO:0006364)3.03898132
64pseudouridine synthesis (GO:0001522)3.01268264
65rRNA metabolic process (GO:0016072)2.99532051
66sequestering of actin monomers (GO:0042989)2.98526422
67protein-cofactor linkage (GO:0018065)2.97625541
68branched-chain amino acid catabolic process (GO:0009083)2.96389130
69UTP biosynthetic process (GO:0006228)2.93415282
70hydrogen ion transmembrane transport (GO:1902600)2.91167601
71proteasome assembly (GO:0043248)2.87932146
72chromatin remodeling at centromere (GO:0031055)2.86867282
73DNA damage response, detection of DNA damage (GO:0042769)2.84941045
74regulation of mitochondrial translation (GO:0070129)2.84717522
75ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84333069
76mannosylation (GO:0097502)2.82393813
77ubiquinone biosynthetic process (GO:0006744)2.80267684
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78279672
79signal peptide processing (GO:0006465)2.71197799
80preassembly of GPI anchor in ER membrane (GO:0016254)2.70854066
81RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.70450804
82cell proliferation in forebrain (GO:0021846)2.68392746
83positive regulation of respiratory burst (GO:0060267)2.66405571
84UTP metabolic process (GO:0046051)2.64679068
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61567691
86ribosome biogenesis (GO:0042254)2.57977880
87tRNA processing (GO:0008033)2.57490032
88proton transport (GO:0015992)2.56786809
89negative regulation of ligase activity (GO:0051352)2.56050499
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56050499
91axoneme assembly (GO:0035082)2.54494816
92CENP-A containing nucleosome assembly (GO:0034080)2.54360453
93regulation of cellular amino acid metabolic process (GO:0006521)2.53857404
94protein targeting (GO:0006605)2.53602266
95protein targeting to mitochondrion (GO:0006626)2.53335435
96ubiquinone metabolic process (GO:0006743)2.52890198
97intracellular protein transmembrane import (GO:0044743)2.52721050
98CTP metabolic process (GO:0046036)2.52593581
99CTP biosynthetic process (GO:0006241)2.52593581
100platelet dense granule organization (GO:0060155)2.51210052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.87426339
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.47254868
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16271856
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44374660
5VDR_22108803_ChIP-Seq_LS180_Human3.26795518
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12077505
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.95853628
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93450530
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90533635
10ZNF274_21170338_ChIP-Seq_K562_Hela2.65887310
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48904649
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.45891813
13VDR_23849224_ChIP-Seq_CD4+_Human2.30072567
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29788059
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22566043
16FOXP3_21729870_ChIP-Seq_TREG_Human2.19148507
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16640964
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15177879
19EZH2_22144423_ChIP-Seq_EOC_Human2.14235965
20IGF1R_20145208_ChIP-Seq_DFB_Human2.10119326
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94600472
22MYC_18940864_ChIP-ChIP_HL60_Human1.92249346
23IRF1_19129219_ChIP-ChIP_H3396_Human1.86965048
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84459944
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82256926
26ELK1_19687146_ChIP-ChIP_HELA_Human1.80199544
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79475531
28TTF2_22483619_ChIP-Seq_HELA_Human1.71858892
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.67865449
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67295472
31EWS_26573619_Chip-Seq_HEK293_Human1.64881094
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.50433565
33GABP_19822575_ChIP-Seq_HepG2_Human1.49392329
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.49207445
35XRN2_22483619_ChIP-Seq_HELA_Human1.48071815
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47156529
37TP53_22573176_ChIP-Seq_HFKS_Human1.43164500
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43027679
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40741198
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.38647679
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37835962
42FUS_26573619_Chip-Seq_HEK293_Human1.35044484
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34510124
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33854469
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33050607
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31627586
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31622406
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31273233
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28107328
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26496541
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26303851
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23288656
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23288656
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23204744
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22259433
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18750671
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17090778
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16345531
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15744748
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.14542599
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14198840
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12569091
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11740814
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11584378
65P300_19829295_ChIP-Seq_ESCs_Human1.11375383
66SOX2_19829295_ChIP-Seq_ESCs_Human1.06840826
67NANOG_19829295_ChIP-Seq_ESCs_Human1.06840826
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.06242978
69AR_20517297_ChIP-Seq_VCAP_Human1.06129747
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04357702
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03040174
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.02850712
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01491755
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00108499
75NANOG_20526341_ChIP-Seq_ESCs_Human0.99370686
76NCOR_22424771_ChIP-Seq_293T_Human0.99293901
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99275311
78TAF2_19829295_ChIP-Seq_ESCs_Human0.98851736
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97287504
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97285242
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96850970
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95819922
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95156610
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91207097
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91148220
86CBP_20019798_ChIP-Seq_JUKART_Human0.91148220
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90919433
88RNF2_27304074_Chip-Seq_NSC_Mouse0.90624708
89DCP1A_22483619_ChIP-Seq_HELA_Human0.89919786
90ERA_21632823_ChIP-Seq_H3396_Human0.89692748
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.88648768
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.88186636
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86930836
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85345765
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.85037084
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84401598
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81435575
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81213575
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.80955829
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80465744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.97326116
2MP0006292_abnormal_olfactory_placode5.53578158
3MP0008877_abnormal_DNA_methylation3.34757958
4MP0003646_muscle_fatigue2.60336846
5MP0002837_dystrophic_cardiac_calcinosis2.58323655
6MP0003136_yellow_coat_color2.29055206
7MP0008789_abnormal_olfactory_epithelium2.25514850
8MP0001293_anophthalmia2.12295153
9MP0002736_abnormal_nociception_after2.09138309
10MP0002653_abnormal_ependyma_morphology2.06193766
11MP0001348_abnormal_lacrimal_gland2.04597067
12MP0002163_abnormal_gland_morphology2.03398227
13MP0003787_abnormal_imprinting1.85894699
14MP0002138_abnormal_hepatobiliary_system1.84656919
15MP0005499_abnormal_olfactory_system1.82902362
16MP0005394_taste/olfaction_phenotype1.82902362
17MP0001485_abnormal_pinna_reflex1.82759797
18MP0008872_abnormal_physiological_respon1.80183949
19MP0002638_abnormal_pupillary_reflex1.80008252
20MP0004142_abnormal_muscle_tone1.76098981
21MP0005084_abnormal_gallbladder_morpholo1.73689864
22MP0005646_abnormal_pituitary_gland1.70292846
23MP0004147_increased_porphyrin_level1.69408162
24MP0001968_abnormal_touch/_nociception1.65464677
25MP0002102_abnormal_ear_morphology1.62748733
26MP0000049_abnormal_middle_ear1.62508412
27MP0003122_maternal_imprinting1.61697073
28MP0003878_abnormal_ear_physiology1.60004058
29MP0005377_hearing/vestibular/ear_phenot1.60004058
30MP0006072_abnormal_retinal_apoptosis1.58457103
31MP0002277_abnormal_respiratory_mucosa1.55400065
32MP0005551_abnormal_eye_electrophysiolog1.52084540
33MP0005379_endocrine/exocrine_gland_phen1.51975531
34MP0002938_white_spotting1.51110297
35MP0001188_hyperpigmentation1.51094794
36MP0000372_irregular_coat_pigmentation1.50781469
37MP0005671_abnormal_response_to1.49529558
38MP0004145_abnormal_muscle_electrophysio1.43602963
39MP0000631_abnormal_neuroendocrine_gland1.42834957
40MP0008058_abnormal_DNA_repair1.36434136
41MP0001529_abnormal_vocalization1.29206971
42MP0002272_abnormal_nervous_system1.27321589
43MP0004742_abnormal_vestibular_system1.25502285
44MP0003186_abnormal_redox_activity1.22787457
45MP0002095_abnormal_skin_pigmentation1.19172429
46MP0003567_abnormal_fetal_cardiomyocyte1.13247765
47MP0005389_reproductive_system_phenotype1.12256520
48MP0005645_abnormal_hypothalamus_physiol1.11625346
49MP0001984_abnormal_olfaction1.11119423
50MP0001905_abnormal_dopamine_level1.10889480
51MP0003880_abnormal_central_pattern1.10420451
52MP0003121_genomic_imprinting1.08860365
53MP0004885_abnormal_endolymph1.07553145
54MP0002160_abnormal_reproductive_system1.06869876
55MP0003786_premature_aging1.06606933
56MP0005174_abnormal_tail_pigmentation1.05959528
57MP0008875_abnormal_xenobiotic_pharmacok1.04934236
58MP0003123_paternal_imprinting1.03936858
59MP0003937_abnormal_limbs/digits/tail_de1.02408127
60MP0001919_abnormal_reproductive_system1.02402677
61MP0008995_early_reproductive_senescence1.01855855
62MP0004133_heterotaxia1.00034365
63MP0006276_abnormal_autonomic_nervous0.98993861
64MP0003693_abnormal_embryo_hatching0.93918047
65MP0009745_abnormal_behavioral_response0.92907709
66MP0002557_abnormal_social/conspecific_i0.92777162
67MP0005253_abnormal_eye_physiology0.92031645
68MP0002234_abnormal_pharynx_morphology0.90400278
69MP0002233_abnormal_nose_morphology0.89505652
70MP0001764_abnormal_homeostasis0.87386419
71MP0001986_abnormal_taste_sensitivity0.86834175
72MP0002876_abnormal_thyroid_physiology0.86651532
73MP0003718_maternal_effect0.86503863
74MP0005636_abnormal_mineral_homeostasis0.84718179
75MP0005195_abnormal_posterior_eye0.83804791
76MP0003195_calcinosis0.83350941
77MP0002210_abnormal_sex_determination0.83318353
78MP0006036_abnormal_mitochondrial_physio0.82256219
79MP0002752_abnormal_somatic_nervous0.81493313
80MP0003119_abnormal_digestive_system0.80526910
81MP0000026_abnormal_inner_ear0.80344579
82MP0005075_abnormal_melanosome_morpholog0.78956554
83MP0001440_abnormal_grooming_behavior0.76800136
84MP0001286_abnormal_eye_development0.76436440
85MP0003938_abnormal_ear_development0.75733375
86MP0001970_abnormal_pain_threshold0.74713665
87MP0004957_abnormal_blastocyst_morpholog0.74638390
88MP0002822_catalepsy0.73904554
89MP0001486_abnormal_startle_reflex0.72553939
90MP0001963_abnormal_hearing_physiology0.70784312
91MP0009046_muscle_twitch0.69445782
92MP0003011_delayed_dark_adaptation0.68797147
93MP0003806_abnormal_nucleotide_metabolis0.68173429
94MP0000653_abnormal_sex_gland0.67245505
95MP0001929_abnormal_gametogenesis0.67178817
96MP0003936_abnormal_reproductive_system0.65686869
97MP0009333_abnormal_splenocyte_physiolog0.64271935
98MP0001145_abnormal_male_reproductive0.64043355
99MP0002928_abnormal_bile_duct0.63751193
100MP0008775_abnormal_heart_ventricle0.63310871

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.82779034
2Reticulocytopenia (HP:0001896)4.52616224
3Acute encephalopathy (HP:0006846)4.30505986
4Abnormal mitochondria in muscle tissue (HP:0008316)4.25172994
5Mitochondrial inheritance (HP:0001427)4.13600275
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.99814271
7Progressive macrocephaly (HP:0004481)3.92103096
8Increased CSF lactate (HP:0002490)3.77771640
9Increased hepatocellular lipid droplets (HP:0006565)3.55502031
10Pancreatic cysts (HP:0001737)3.37327744
11Pancreatic fibrosis (HP:0100732)3.35809917
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.27173064
13Cerebral edema (HP:0002181)3.24856460
14Hepatocellular necrosis (HP:0001404)3.24254913
15Colon cancer (HP:0003003)3.22144591
16Lipid accumulation in hepatocytes (HP:0006561)3.19412190
173-Methylglutaconic aciduria (HP:0003535)3.15354096
18Macrocytic anemia (HP:0001972)3.14330725
19Septo-optic dysplasia (HP:0100842)3.08945837
20Abnormal rod and cone electroretinograms (HP:0008323)3.08729190
21True hermaphroditism (HP:0010459)3.02072515
22Abnormality of midbrain morphology (HP:0002418)2.98851597
23Molar tooth sign on MRI (HP:0002419)2.98851597
24Hepatic necrosis (HP:0002605)2.90772748
25Optic disc pallor (HP:0000543)2.90098435
26Abnormality of cells of the erythroid lineage (HP:0012130)2.88882046
27Renal Fanconi syndrome (HP:0001994)2.88642856
28Asplenia (HP:0001746)2.76108821
29Pendular nystagmus (HP:0012043)2.73131570
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.72066145
31Increased serum lactate (HP:0002151)2.61812723
32Hyperglycinemia (HP:0002154)2.59710924
33Sclerocornea (HP:0000647)2.57525113
34Aplastic anemia (HP:0001915)2.51407935
35Pallor (HP:0000980)2.51005768
36Nephronophthisis (HP:0000090)2.49656961
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48290894
38Increased intramyocellular lipid droplets (HP:0012240)2.46086047
39Lactic acidosis (HP:0003128)2.44169784
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43341312
41Abnormality of alanine metabolism (HP:0010916)2.43341312
42Hyperalaninemia (HP:0003348)2.43341312
43Abnormal biliary tract physiology (HP:0012439)2.35168231
44Bile duct proliferation (HP:0001408)2.35168231
45Abnormal number of erythroid precursors (HP:0012131)2.29372396
46Lethargy (HP:0001254)2.28825892
47Congenital stationary night blindness (HP:0007642)2.28254098
48Abnormality of the phalanges of the 5th finger (HP:0004213)2.26968594
49Attenuation of retinal blood vessels (HP:0007843)2.26112687
50Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25033105
51Anencephaly (HP:0002323)2.23201045
52Leukodystrophy (HP:0002415)2.23148565
53Abolished electroretinogram (ERG) (HP:0000550)2.22576118
54Abnormal ciliary motility (HP:0012262)2.19945324
55Medial flaring of the eyebrow (HP:0010747)2.15967082
56Absent thumb (HP:0009777)2.13628240
57Exertional dyspnea (HP:0002875)2.07215997
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05999916
59Respiratory failure (HP:0002878)2.02904523
60Methylmalonic aciduria (HP:0012120)2.02402242
61Respiratory difficulties (HP:0002880)2.01225662
62Exercise intolerance (HP:0003546)2.00871430
63Constricted visual fields (HP:0001133)2.00648711
64Rib fusion (HP:0000902)2.00577364
65Cystic liver disease (HP:0006706)1.98837748
66Abnormality of the renal medulla (HP:0100957)1.98690578
67Abnormality of urine glucose concentration (HP:0011016)1.97641362
68Glycosuria (HP:0003076)1.97641362
69Postaxial foot polydactyly (HP:0001830)1.97625124
70Abnormality of the labia minora (HP:0012880)1.95785316
71Decreased central vision (HP:0007663)1.95725430
72Methylmalonic acidemia (HP:0002912)1.95673354
73Optic nerve hypoplasia (HP:0000609)1.95456886
74Increased muscle lipid content (HP:0009058)1.95024149
75Aplasia/hypoplasia of the uterus (HP:0008684)1.93448650
76Hypoplasia of the uterus (HP:0000013)1.93137348
77Pancytopenia (HP:0001876)1.91997763
78Abnormal respiratory motile cilium physiology (HP:0012261)1.91480015
79Abnormality of serum amino acid levels (HP:0003112)1.90312575
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88318487
81Absent septum pellucidum (HP:0001331)1.88261055
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86984937
83Abnormality of renal resorption (HP:0011038)1.86854460
84Abnormality of the renal cortex (HP:0011035)1.85314328
85Stenosis of the external auditory canal (HP:0000402)1.84601437
86Hyperphosphaturia (HP:0003109)1.84368131
87Congenital, generalized hypertrichosis (HP:0004540)1.83814740
88Supernumerary spleens (HP:0009799)1.83300749
89Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83275964
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.82688136
91Absent/shortened dynein arms (HP:0200106)1.82688136
92Abnormal drinking behavior (HP:0030082)1.82148032
93Polydipsia (HP:0001959)1.82148032
94Type II lissencephaly (HP:0007260)1.81406387
95Elevated erythrocyte sedimentation rate (HP:0003565)1.80970846
96Abnormal respiratory epithelium morphology (HP:0012253)1.80459376
97Abnormal respiratory motile cilium morphology (HP:0005938)1.80459376
98Maternal diabetes (HP:0009800)1.79124163
99Male pseudohermaphroditism (HP:0000037)1.78453564
100Ketosis (HP:0001946)1.77628345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.44141076
2STK163.00824942
3BCKDK2.97211215
4WNK42.67518135
5NUAK12.40546793
6WNK32.38434008
7MAP4K22.26899700
8VRK22.25260057
9ADRBK22.10269652
10KDR2.01000656
11TNIK1.95201635
12CDK191.94945937
13TLK11.91914638
14DYRK21.88273675
15BUB11.85712021
16TXK1.83348182
17FRK1.79334810
18GRK11.77353458
19BMPR1B1.70059347
20PBK1.60924013
21TRIM281.60691710
22VRK11.56933559
23CDC71.55191123
24LIMK11.48787712
25CASK1.43832322
26MKNK21.43247691
27TIE11.33468781
28INSRR1.29344566
29PINK11.25976566
30TESK21.25586928
31MAP3K121.24882314
32PASK1.23156695
33MAP4K11.23092952
34NME21.20538002
35PRKCQ1.17829627
36MKNK11.12014538
37PLK41.11917159
38STK391.10399211
39PLK31.01379368
40MAP3K40.98452460
41MAP2K70.98201816
42LRRK20.97618218
43SRPK10.92670817
44ITK0.91435600
45TAOK30.88476693
46PRKCG0.86314677
47PLK10.85999571
48MST40.85613884
49BRSK20.85008707
50NME10.82691749
51TGFBR10.81966204
52ACVR1B0.79546348
53PDK20.79512534
54ADRBK10.78719374
55PIK3CA0.78532555
56WEE10.77218454
57NEK10.76788775
58MAPK130.74497256
59CAMK10.73289481
60TEC0.73155957
61EIF2AK30.72061902
62RPS6KA50.71203293
63AURKA0.69209886
64OXSR10.67450505
65TAF10.67109247
66CSNK2A20.66953397
67MAP3K110.65549426
68BRSK10.63862890
69EIF2AK10.63818012
70PLK20.62647800
71MAP3K90.61741306
72PRKD30.61454645
73MINK10.60275657
74ATR0.58255068
75MAP2K60.57455764
76AURKB0.56467314
77ABL20.55740015
78PRKACA0.54373806
79CSNK2A10.52337737
80IKBKB0.50086325
81PRKCI0.49093523
82CAMKK20.48753700
83CHEK20.46983363
84TSSK60.46411684
85CSNK1E0.44329199
86PRKCA0.41838114
87MYLK0.41751595
88OBSCN0.41373341
89CSNK1G10.39147570
90ERBB40.37365939
91CAMK2A0.37337437
92PIK3CG0.36414816
93GRK70.36059031
94PIM20.35863178
95PRKCE0.34031618
96BTK0.33751083
97CSNK1A10.33119359
98DAPK30.32767739
99EPHA40.31713095
100CSNK1G20.30509786

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.63613556
2Oxidative phosphorylation_Homo sapiens_hsa001904.10161175
3Parkinsons disease_Homo sapiens_hsa050123.59063865
4Proteasome_Homo sapiens_hsa030503.43385002
5Protein export_Homo sapiens_hsa030603.08474635
6RNA polymerase_Homo sapiens_hsa030202.90963977
7Huntingtons disease_Homo sapiens_hsa050162.41563619
8Alzheimers disease_Homo sapiens_hsa050102.34780372
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26702613
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11683783
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10446871
12Cardiac muscle contraction_Homo sapiens_hsa042602.05394147
13RNA degradation_Homo sapiens_hsa030181.90945627
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82742879
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73196663
16Primary immunodeficiency_Homo sapiens_hsa053401.61744161
17Homologous recombination_Homo sapiens_hsa034401.57964657
18Mismatch repair_Homo sapiens_hsa034301.56173824
19Pyrimidine metabolism_Homo sapiens_hsa002401.55718465
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53449813
21DNA replication_Homo sapiens_hsa030301.41895413
22Propanoate metabolism_Homo sapiens_hsa006401.41183434
23Basal transcription factors_Homo sapiens_hsa030221.33492905
24Phototransduction_Homo sapiens_hsa047441.28621414
25Linoleic acid metabolism_Homo sapiens_hsa005911.27088214
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24956543
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23666295
28Peroxisome_Homo sapiens_hsa041461.21156097
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20397501
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16412036
31One carbon pool by folate_Homo sapiens_hsa006701.15058066
32Fanconi anemia pathway_Homo sapiens_hsa034601.14782730
33Butanoate metabolism_Homo sapiens_hsa006501.13428089
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.11861036
35RNA transport_Homo sapiens_hsa030131.11284661
36Nucleotide excision repair_Homo sapiens_hsa034201.10866260
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10392809
38Base excision repair_Homo sapiens_hsa034101.08070600
39Spliceosome_Homo sapiens_hsa030401.06837092
40Purine metabolism_Homo sapiens_hsa002301.06422694
41Sulfur relay system_Homo sapiens_hsa041221.03503228
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02636192
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01858670
44Allograft rejection_Homo sapiens_hsa053301.01291479
45Nitrogen metabolism_Homo sapiens_hsa009100.98719675
46Autoimmune thyroid disease_Homo sapiens_hsa053200.97421793
47Asthma_Homo sapiens_hsa053100.92898634
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.91837892
49Steroid biosynthesis_Homo sapiens_hsa001000.87671966
50Graft-versus-host disease_Homo sapiens_hsa053320.83858784
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82528521
52Tryptophan metabolism_Homo sapiens_hsa003800.82421377
53Nicotine addiction_Homo sapiens_hsa050330.81860083
54Metabolic pathways_Homo sapiens_hsa011000.79990681
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78061461
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76440919
57Caffeine metabolism_Homo sapiens_hsa002320.75401895
58Type I diabetes mellitus_Homo sapiens_hsa049400.75174052
59Retinol metabolism_Homo sapiens_hsa008300.73279668
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72594646
61Sulfur metabolism_Homo sapiens_hsa009200.65858950
62Olfactory transduction_Homo sapiens_hsa047400.64279947
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62196135
64Chemical carcinogenesis_Homo sapiens_hsa052040.61321246
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.60758391
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57414267
67Antigen processing and presentation_Homo sapiens_hsa046120.55314713
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53420453
69Fatty acid degradation_Homo sapiens_hsa000710.52034633
70Ether lipid metabolism_Homo sapiens_hsa005650.49534553
71Non-homologous end-joining_Homo sapiens_hsa034500.49204982
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.48671796
73beta-Alanine metabolism_Homo sapiens_hsa004100.48335873
74Fat digestion and absorption_Homo sapiens_hsa049750.47814048
75Fatty acid elongation_Homo sapiens_hsa000620.44637090
76Folate biosynthesis_Homo sapiens_hsa007900.43356296
77Arachidonic acid metabolism_Homo sapiens_hsa005900.42961828
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39605392
79Hematopoietic cell lineage_Homo sapiens_hsa046400.39140626
80Vitamin digestion and absorption_Homo sapiens_hsa049770.37087029
81Glutathione metabolism_Homo sapiens_hsa004800.36515903
82Selenocompound metabolism_Homo sapiens_hsa004500.35074126
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34580032
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34436801
85Pyruvate metabolism_Homo sapiens_hsa006200.33217441
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.32543766
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30924065
88Arginine and proline metabolism_Homo sapiens_hsa003300.30298593
89Hedgehog signaling pathway_Homo sapiens_hsa043400.29070422
90Morphine addiction_Homo sapiens_hsa050320.28644569
91T cell receptor signaling pathway_Homo sapiens_hsa046600.28454458
92Basal cell carcinoma_Homo sapiens_hsa052170.28432080
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28161790
94Serotonergic synapse_Homo sapiens_hsa047260.26538188
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.25909687
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25164013
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24309549
98Insulin secretion_Homo sapiens_hsa049110.23415312
99Collecting duct acid secretion_Homo sapiens_hsa049660.21956312
100Taste transduction_Homo sapiens_hsa047420.21187028

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