ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of execution phase of apoptosis (GO:1900118)	9.20864386
2	ribonucleoprotein complex disassembly (GO:0032988)	7.59741816
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	7.14840673
4	organelle disassembly (GO:1903008)	6.98292549
5	glycerophospholipid catabolic process (GO:0046475)	6.78946221
6	cytolysis (GO:0019835)	6.33125766
7	GTP biosynthetic process (GO:0006183)	6.15053999
8	regulation of isotype switching to IgG isotypes (GO:0048302)	6.09787382
9	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.94429296
10	parturition (GO:0007567)	5.57292642
11	protein prenylation (GO:0018342)	5.57098666
12	prenylation (GO:0097354)	5.57098666
13	GDP-mannose metabolic process (GO:0019673)	5.45929737
14	UTP biosynthetic process (GO:0006228)	5.29447218
15	behavioral response to nicotine (GO:0035095)	5.11435401
16	L-fucose catabolic process (GO:0042355)	5.07685540
17	fucose catabolic process (GO:0019317)	5.07685540
18	L-fucose metabolic process (GO:0042354)	5.07685540
19	positive regulation of cAMP-mediated signaling (GO:0043950)	5.04010443
20	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.79209804
21	signal peptide processing (GO:0006465)	4.73765385
22	UTP metabolic process (GO:0046051)	4.70056780
23	T cell migration (GO:0072678)	4.68784427
24	platelet dense granule organization (GO:0060155)	4.66363474
25	DNA deamination (GO:0045006)	4.64609674
26	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.40246299
27	cytidine catabolic process (GO:0006216)	4.33098220
28	cytidine deamination (GO:0009972)	4.33098220
29	cytidine metabolic process (GO:0046087)	4.33098220
30	detection of light stimulus involved in sensory perception (GO:0050962)	4.31091018
31	detection of light stimulus involved in visual perception (GO:0050908)	4.31091018
32	positive regulation of isotype switching (GO:0045830)	4.27575887
33	ribosomal small subunit assembly (GO:0000028)	4.16443327
34	regulation of regulatory T cell differentiation (GO:0045589)	4.10208303
35	negative regulation of B cell apoptotic process (GO:0002903)	4.09381749
36	positive regulation of interleukin-17 production (GO:0032740)	4.05865126
37	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.01620670
38	nucleoside diphosphate phosphorylation (GO:0006165)	4.01158811
39	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.96117710
40	CTP metabolic process (GO:0046036)	3.93525145
41	CTP biosynthetic process (GO:0006241)	3.93525145
42	regulation of execution phase of apoptosis (GO:1900117)	3.90599708
43	guanosine-containing compound biosynthetic process (GO:1901070)	3.86857704
44	positive regulation of DNA recombination (GO:0045911)	3.68019509
45	synaptic transmission, cholinergic (GO:0007271)	3.66973991
46	facial nerve structural organization (GO:0021612)	3.62313693
47	protein refolding (GO:0042026)	3.50402405
48	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.44005185
49	coenzyme A biosynthetic process (GO:0015937)	3.42294933
50	tryptophan catabolic process (GO:0006569)	3.40641303
51	indole-containing compound catabolic process (GO:0042436)	3.40641303
52	indolalkylamine catabolic process (GO:0046218)	3.40641303
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.35472264
54	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.34535752
55	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.34501772
56	regulation of metalloenzyme activity (GO:0048552)	3.31427503
57	regulation of activation of Janus kinase activity (GO:0010533)	3.31169673
58	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.29335597
59	phospholipid catabolic process (GO:0009395)	3.27786759
60	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.25675748
61	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.21690342
62	lymphocyte chemotaxis (GO:0048247)	3.19870001
63	coenzyme A metabolic process (GO:0015936)	3.18982320
64	fucose metabolic process (GO:0006004)	3.14905790
65	nucleoside diphosphate catabolic process (GO:0009134)	3.12190330
66	regulation of immunoglobulin secretion (GO:0051023)	3.11993067
67	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.10003916
68	sleep (GO:0030431)	3.06952492
69	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.05640968
70	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.04079762
71	negative regulation of chemokine production (GO:0032682)	3.04027183
72	nucleotide-sugar biosynthetic process (GO:0009226)	3.00244627
73	cobalamin metabolic process (GO:0009235)	2.99051214
74	negative regulation of phagocytosis (GO:0050765)	2.98079500
75	regulation of T cell receptor signaling pathway (GO:0050856)	2.97412207
76	protein deneddylation (GO:0000338)	2.95956449
77	regulation of cAMP-mediated signaling (GO:0043949)	2.94565203
78	positive regulation of action potential (GO:0045760)	2.94151115
79	cellular ketone body metabolic process (GO:0046950)	2.90611174
80	indolalkylamine metabolic process (GO:0006586)	2.89558855
81	phasic smooth muscle contraction (GO:0014821)	2.88833906
82	nucleoside diphosphate metabolic process (GO:0009132)	2.88220626
83	ketone body metabolic process (GO:1902224)	2.86980558
84	seminiferous tubule development (GO:0072520)	2.86669348
85	kynurenine metabolic process (GO:0070189)	2.83087300
86	positive regulation of protein targeting to membrane (GO:0090314)	2.81086645
87	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	2.81069006
88	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.80991924
89	tryptophan metabolic process (GO:0006568)	2.80957880
90	mannose metabolic process (GO:0006013)	2.79158455
91	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.78185719
92	chemokine-mediated signaling pathway (GO:0070098)	2.78166930
93	pyrimidine nucleoside catabolic process (GO:0046135)	2.76961930
94	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.74659977
95	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.74017725
96	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.71169594
97	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	2.70497543
98	synaptic transmission, dopaminergic (GO:0001963)	2.67347671
99	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.66207106
100	positive regulation of B cell mediated immunity (GO:0002714)	2.66207106

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.88016190
2	VDR_22108803_ChIP-Seq_LS180_Human	3.41979203
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18364642
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.18051136
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.98431993
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.97837535
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97787677
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.77651743
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52408648
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44948921
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26691791
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.19882882
13	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	2.16074525
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.10453939
15	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.03610472
16	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.02443154
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.02122743
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.98793398
19	P300_19829295_ChIP-Seq_ESCs_Human	1.92390357
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.92314206
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.81729016
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.80035867
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.71922024
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69469316
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.69036169
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67263083
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59820417
28	NCOR_22424771_ChIP-Seq_293T_Human	1.59388867
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58896983
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56992250
31	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.56293088
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52675426
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52402893
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51301749
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50771769
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48912532
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48898477
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.43717305
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39551594
40	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38401187
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33617784
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33617784
43	MYC_19829295_ChIP-Seq_ESCs_Human	1.33094336
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.33005373
45	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30441755
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.30378031
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29737120
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29737120
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29268046
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26140088
51	GATA3_26560356_Chip-Seq_TH2_Human	1.23305596
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22372000
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22372000
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.22116109
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21713769
56	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.21590136
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21317963
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21244788
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.19547783
60	MYB_26560356_Chip-Seq_TH1_Human	1.18971090
61	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16902075
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14446097
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13744942
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13190823
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.12766527
66	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.12524484
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12408913
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10776759
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09331539
70	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07679661
71	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07189374
72	ERG_20517297_ChIP-Seq_VCAP_Human	1.07126841
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06681342
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06104272
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05932358
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04879874
77	ERA_21632823_ChIP-Seq_H3396_Human	1.04641961
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04492171
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.03393349
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97245379
81	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96827985
82	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96254665
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95932115
84	BCL6_27268052_Chip-Seq_Bcells_Human	0.95626633
85	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.95413166
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95327237
87	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93576390
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.93282771
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93005541
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.92910524
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.91600192
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91600192
93	CEBPB_22108803_ChIP-Seq_LS180_Human	0.87213064
94	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.86363394
95	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.85769958
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84965140
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.84491166
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84482655
99	TAF15_26573619_Chip-Seq_HEK293_Human	0.83899098
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83471427

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	4.40905864
2	MP0004885_abnormal_endolymph	4.02673881
3	MP0005671_abnormal_response_to	3.98336572
4	MP0001986_abnormal_taste_sensitivity	3.49710405
5	MP0003045_fibrosis	3.44161200
6	MP0001853_heart_inflammation	3.16783403
7	MP0003300_gastrointestinal_ulcer	3.06620450
8	MP0005377_hearing/vestibular/ear_phenot	3.04096623
9	MP0003878_abnormal_ear_physiology	3.04096623
10	MP0003195_calcinosis	2.73948655
11	MP0003879_abnormal_hair_cell	2.70277538
12	MP0003136_yellow_coat_color	2.69645151
13	MP0010368_abnormal_lymphatic_system	2.56813969
14	MP0004510_myositis	2.51529792
15	MP0009785_altered_susceptibility_to	2.43942338
16	MP0001529_abnormal_vocalization	2.38512974
17	MP0000372_irregular_coat_pigmentation	2.33231325
18	MP0001485_abnormal_pinna_reflex	2.20732588
19	MP0002102_abnormal_ear_morphology	1.99855934
20	MP0001835_abnormal_antigen_presentation	1.97925704
21	MP0005171_absent_coat_pigmentation	1.92022273
22	MP0005379_endocrine/exocrine_gland_phen	1.85879196
23	MP0003718_maternal_effect	1.85779892
24	MP0000604_amyloidosis	1.80951601
25	MP0002089_abnormal_postnatal_growth/wei	1.79870169
26	MP0000371_diluted_coat_color	1.75289821
27	MP0005165_increased_susceptibility_to	1.63122744
28	MP0004145_abnormal_muscle_electrophysio	1.57663594
29	MP0010386_abnormal_urinary_bladder	1.56856034
30	MP0002234_abnormal_pharynx_morphology	1.54098455
31	MP0005551_abnormal_eye_electrophysiolog	1.54052973
32	MP0005360_urolithiasis	1.50781719
33	MP0005395_other_phenotype	1.48979220
34	MP0002168_other_aberrant_phenotype	1.42546772
35	MP0003786_premature_aging	1.39628790
36	MP0002735_abnormal_chemical_nociception	1.36728865
37	MP0005025_abnormal_response_to	1.36316361
38	MP0002095_abnormal_skin_pigmentation	1.33312450
39	MP0005310_abnormal_salivary_gland	1.32468411
40	MP0000465_gastrointestinal_hemorrhage	1.29133159
41	MP0002163_abnormal_gland_morphology	1.27124031
42	MP0002733_abnormal_thermal_nociception	1.27123935
43	MP0008872_abnormal_physiological_respon	1.20798527
44	MP0006072_abnormal_retinal_apoptosis	1.12012298
45	MP0001486_abnormal_startle_reflex	1.11586963
46	MP0002751_abnormal_autonomic_nervous	1.09920881
47	MP0000538_abnormal_urinary_bladder	1.07925433
48	MP0005332_abnormal_amino_acid	1.06921144
49	MP0002075_abnormal_coat/hair_pigmentati	1.03872477
50	MP0005166_decreased_susceptibility_to	1.02536684
51	MP0002138_abnormal_hepatobiliary_system	0.99664860
52	MP0005075_abnormal_melanosome_morpholog	0.99241741
53	MP0005408_hypopigmentation	0.97464685
54	MP0001970_abnormal_pain_threshold	0.96785915
55	MP0000049_abnormal_middle_ear	0.96547464
56	MP0008875_abnormal_xenobiotic_pharmacok	0.96345519
57	MP0005645_abnormal_hypothalamus_physiol	0.95725587
58	MP0005174_abnormal_tail_pigmentation	0.93390389
59	MP0001186_pigmentation_phenotype	0.93104222
60	MP0006292_abnormal_olfactory_placode	0.89527541
61	MP0000026_abnormal_inner_ear	0.89125375
62	MP0004484_altered_response_of	0.88467764
63	MP0005595_abnormal_vascular_smooth	0.88379006
64	MP0001968_abnormal_touch/_nociception	0.85311288
65	MP0002693_abnormal_pancreas_physiology	0.83563479
66	MP0002837_dystrophic_cardiac_calcinosis	0.83043630
67	MP0002148_abnormal_hypersensitivity_rea	0.80410560
68	MP0003866_abnormal_defecation	0.78659318
69	MP0003646_muscle_fatigue	0.77520409
70	MP0009745_abnormal_behavioral_response	0.75745599
71	MP0002272_abnormal_nervous_system	0.75715643
72	MP0002876_abnormal_thyroid_physiology	0.75153714
73	MP0001664_abnormal_digestion	0.75114680
74	MP0000613_abnormal_salivary_gland	0.74976571
75	MP0001440_abnormal_grooming_behavior	0.72487767
76	MP0002938_white_spotting	0.71934031
77	MP0008469_abnormal_protein_level	0.71130796
78	MP0001765_abnormal_ion_homeostasis	0.70926507
79	MP0001963_abnormal_hearing_physiology	0.70034695
80	MP0004742_abnormal_vestibular_system	0.69491916
81	MP0004142_abnormal_muscle_tone	0.68302141
82	MP0003448_altered_tumor_morphology	0.67255707
83	MP0008961_abnormal_basal_metabolism	0.67159251
84	MP0001879_abnormal_lymphatic_vessel	0.66624218
85	MP0001958_emphysema	0.64446732
86	MP0002090_abnormal_vision	0.64006097
87	MP0002166_altered_tumor_susceptibility	0.63270708
88	MP0003186_abnormal_redox_activity	0.62713965
89	MP0000427_abnormal_hair_cycle	0.62027777
90	MP0005167_abnormal_blood-brain_barrier	0.60963024
91	MP0000428_abnormal_craniofacial_morphol	0.60945609
92	MP0005636_abnormal_mineral_homeostasis	0.60734543
93	MP0005253_abnormal_eye_physiology	0.60577048
94	MP0001501_abnormal_sleep_pattern	0.60203866
95	MP0003890_abnormal_embryonic-extraembry	0.59749832
96	MP0001293_anophthalmia	0.59309643
97	MP0004019_abnormal_vitamin_homeostasis	0.59229689
98	MP0001764_abnormal_homeostasis	0.58843720
99	MP0000015_abnormal_ear_pigmentation	0.58507606
100	MP0003137_abnormal_impulse_conducting	0.58484266

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	8.15448180
2	Homocystinuria (HP:0002156)	5.65003013
3	Abnormality of homocysteine metabolism (HP:0010919)	5.65003013
4	Elevated erythrocyte sedimentation rate (HP:0003565)	5.30567490
5	Aplasia/Hypoplasia of the macula (HP:0008059)	5.12497727
6	Aplasia/Hypoplasia affecting the retina (HP:0008061)	4.82611976
7	Methylmalonic acidemia (HP:0002912)	4.80692031
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.69894866
9	Abnormal rod and cone electroretinograms (HP:0008323)	4.65680919
10	Abnormal auditory evoked potentials (HP:0006958)	4.08882767
11	Methylmalonic aciduria (HP:0012120)	3.69861556
12	Nonprogressive disorder (HP:0003680)	3.45675034
13	Congenital stationary night blindness (HP:0007642)	3.36990816
14	Premature ovarian failure (HP:0008209)	3.33774340
15	Abnormality of methionine metabolism (HP:0010901)	3.33123941
16	Sclerocornea (HP:0000647)	3.22184154
17	Abnormal number of erythroid precursors (HP:0012131)	3.11927290
18	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.11388488
19	Oral leukoplakia (HP:0002745)	3.04124004
20	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.02586663
21	Abnormality of vitamin B metabolism (HP:0004340)	3.02584253
22	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.92987475
23	Generalized aminoaciduria (HP:0002909)	2.80582067
24	Hypothermia (HP:0002045)	2.78637902
25	Prostate neoplasm (HP:0100787)	2.74195272
26	Pancytopenia (HP:0001876)	2.71667160
27	Degeneration of anterior horn cells (HP:0002398)	2.67237881
28	Abnormality of the anterior horn cell (HP:0006802)	2.67237881
29	Increased hepatocellular lipid droplets (HP:0006565)	2.66404325
30	Hypoplasia of the fovea (HP:0007750)	2.63487108
31	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.63487108
32	Palpitations (HP:0001962)	2.62558837
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.61279093
34	T lymphocytopenia (HP:0005403)	2.58018367
35	Acute necrotizing encephalopathy (HP:0006965)	2.50995532
36	Vascular calcification (HP:0004934)	2.49945348
37	Decreased central vision (HP:0007663)	2.43619713
38	Acute encephalopathy (HP:0006846)	2.42149757
39	Lipid accumulation in hepatocytes (HP:0006561)	2.40070888
40	Hepatic necrosis (HP:0002605)	2.39457651
41	Albinism (HP:0001022)	2.36620657
42	Abnormality of T cell number (HP:0011839)	2.34351635
43	Increased intramyocellular lipid droplets (HP:0012240)	2.30262676
44	Hepatocellular necrosis (HP:0001404)	2.30206352
45	Abnormality of T cells (HP:0002843)	2.29464180
46	Abnormality of the fovea (HP:0000493)	2.25885204
47	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.25727739
48	Dicarboxylic aciduria (HP:0003215)	2.25727739
49	Premature graying of hair (HP:0002216)	2.22899234
50	Mitochondrial inheritance (HP:0001427)	2.20404657
51	Pustule (HP:0200039)	2.20206947
52	Decreased lacrimation (HP:0000633)	2.17149788
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.16632340
54	Mitral stenosis (HP:0001718)	2.16094354
55	Generalized hypopigmentation (HP:0007513)	2.14790845
56	Abnormality of T cell physiology (HP:0011840)	2.13478579
57	Progressive macrocephaly (HP:0004481)	2.12620043
58	Large for gestational age (HP:0001520)	2.12406732
59	Cardiovascular calcification (HP:0011915)	2.11936483
60	3-Methylglutaconic aciduria (HP:0003535)	2.10939976
61	Cerebral hypomyelination (HP:0006808)	2.10895816
62	Congenital sensorineural hearing impairment (HP:0008527)	2.10081169
63	Protuberant abdomen (HP:0001538)	2.08652218
64	Abnormality of the parathyroid morphology (HP:0011766)	2.08222082
65	Constricted visual fields (HP:0001133)	2.06789447
66	Alacrima (HP:0000522)	2.06424201
67	Orthostatic hypotension (HP:0001278)	2.05260274
68	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.04806422
69	Abnormality of vitamin metabolism (HP:0100508)	2.03094576
70	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.98354771
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97851606
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97851606
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.97466097
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97466097
75	Microvesicular hepatic steatosis (HP:0001414)	1.94728766
76	Esotropia (HP:0000565)	1.93754662
77	Ventricular fibrillation (HP:0001663)	1.93636155
78	Abnormality of midbrain morphology (HP:0002418)	1.92643343
79	Molar tooth sign on MRI (HP:0002419)	1.92643343
80	Tachypnea (HP:0002789)	1.90230856
81	Increased CSF lactate (HP:0002490)	1.89720983
82	Abnormality of the prostate (HP:0008775)	1.89227226
83	Myokymia (HP:0002411)	1.87786089
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.85757801
85	Increased muscle lipid content (HP:0009058)	1.85573238
86	Prolonged QT interval (HP:0001657)	1.85008977
87	Dysautonomia (HP:0002459)	1.83251763
88	True hermaphroditism (HP:0010459)	1.78886964
89	Metaphyseal dysplasia (HP:0100255)	1.78699775
90	Macrocytic anemia (HP:0001972)	1.76557490
91	Menstrual irregularities (HP:0000858)	1.75292493
92	Wide intermamillary distance (HP:0006610)	1.74720780
93	Furrowed tongue (HP:0000221)	1.69725827
94	Microcytic anemia (HP:0001935)	1.69620412
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.68978019
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68804700
97	Lethargy (HP:0001254)	1.68498078
98	Hypoproteinemia (HP:0003075)	1.66684781
99	Severe combined immunodeficiency (HP:0004430)	1.66091326
100	Thyroiditis (HP:0100646)	1.66085771

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.09728848
2	ADRBK2	3.29139222
3	BCKDK	2.77401731
4	CLK1	2.75957325
5	NEK9	2.75315132
6	ITK	2.37055511
7	TLK1	2.19927387
8	STK24	2.02935563
9	STK16	11.6400905
10	FRK	1.95252664
11	GRK1	1.87664590
12	AKT3	1.73639282
13	NME1	1.73502929
14	DDR2	1.63107759
15	TXK	1.48133326
16	KDR	1.40197532
17	MAP4K2	1.32153112
18	STK3	1.28866266
19	MAPK7	1.14985958
20	EIF2AK1	1.14794791
21	CSK	1.08098786
22	TBK1	1.06790736
23	PAK3	1.03645244
24	TEC	1.01247259
25	PINK1	0.98960042
26	WNK3	0.98699651
27	CSNK1A1L	0.97039512
28	NEK1	0.95236758
29	CSNK1G3	0.92850309
30	GRK7	0.89473804
31	ZAK	0.83713568
32	STK38L	0.82494441
33	ACVR1B	0.75932928
34	NUAK1	0.72962630
35	PHKG2	0.72740311
36	PHKG1	0.72740311
37	BTK	0.70091254
38	CSNK1G2	0.69785472
39	TSSK6	0.69294738
40	MST4	0.67690995
41	CASK	0.67131051
42	ADRBK1	0.63432815
43	CSNK1G1	0.59776863
44	LIMK1	0.58954543
45	RPS6KB1	0.55677852
46	CAMK2D	0.54389301
47	VRK1	0.52789067
48	PIK3CA	0.50625407
49	BMPR1B	0.49773475
50	CAMK2A	0.49590025
51	IRAK1	0.49022962
52	PTK2B	0.46631784
53	PLK4	0.44453711
54	INSRR	0.44450888
55	OXSR1	0.43873642
56	DAPK3	0.42890185
57	BUB1	0.42107320
58	PLK1	0.42095899
59	STK39	0.41954325
60	MAP2K6	0.41921741
61	PRKCG	0.40937521
62	PRKCE	0.40382815
63	PLK3	0.39950726
64	OBSCN	0.39249410
65	EGFR	0.37489532
66	LCK	0.35637827
67	CSNK2A2	0.35450904
68	INSR	0.35093162
69	PRKG1	0.34871734
70	DYRK2	0.34688755
71	PLK2	0.33996688
72	SYK	0.33329824
73	CSNK1A1	0.33300281
74	PRKACA	0.30801792
75	EIF2AK3	0.29338479
76	PRKCB	0.29234032
77	PRKCA	0.28505312
78	ATR	0.27783347
79	ROCK1	0.27298910
80	MAPKAPK5	0.26441808
81	CDK7	0.26244564
82	STK4	0.25298296
83	ERBB3	0.25248292
84	CSNK2A1	0.23314616
85	LYN	0.22547033
86	RPS6KB2	0.21694739
87	PAK4	0.21465981
88	CDK11A	0.19760185
89	PRKCQ	0.19364607
90	TIE1	0.19330264
91	KIT	0.19238785
92	LATS1	0.19201287
93	MAPK15	0.19149925
94	TRIM28	0.17885332
95	ERBB2	0.17876360
96	CDK18	0.16985857
97	AURKA	0.16781948
98	PASK	0.15027356
99	CDK15	0.14946865
100	IGF1R	0.14918976

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.47607967
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.99749010
3	Protein export_Homo sapiens_hsa03060	2.97378395
4	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.58532571
5	Ribosome_Homo sapiens_hsa03010	2.53048862
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.45716543
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.22015558
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.17228839
9	Graft-versus-host disease_Homo sapiens_hsa05332	1.86782588
10	Allograft rejection_Homo sapiens_hsa05330	1.82953776
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.79427228
12	Parkinsons disease_Homo sapiens_hsa05012	1.75175009
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74702858
14	Histidine metabolism_Homo sapiens_hsa00340	1.71184578
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68060212
16	Proteasome_Homo sapiens_hsa03050	1.64746929
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62725163
18	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.60995900
19	Peroxisome_Homo sapiens_hsa04146	1.56377204
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54524260
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.53954183
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53042607
23	Basal transcription factors_Homo sapiens_hsa03022	1.49327634
24	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.46309227
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44115461
26	Serotonergic synapse_Homo sapiens_hsa04726	1.41654429
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39656359
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32068829
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.31793013
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.30054784
31	Caffeine metabolism_Homo sapiens_hsa00232	1.27679444
32	RNA polymerase_Homo sapiens_hsa03020	1.26485511
33	Propanoate metabolism_Homo sapiens_hsa00640	1.26329403
34	Purine metabolism_Homo sapiens_hsa00230	1.17870290
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.11805273
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.10415893
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10167914
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08251043
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.06886671
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06786054
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04496704
42	Nicotine addiction_Homo sapiens_hsa05033	1.03591692
43	Alzheimers disease_Homo sapiens_hsa05010	1.01874198
44	Huntingtons disease_Homo sapiens_hsa05016	1.00737616
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00339248
46	Asthma_Homo sapiens_hsa05310	0.96503507
47	Legionellosis_Homo sapiens_hsa05134	0.94903420
48	Olfactory transduction_Homo sapiens_hsa04740	0.94728873
49	Long-term depression_Homo sapiens_hsa04730	0.90226253
50	Phototransduction_Homo sapiens_hsa04744	0.88157695
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86815671
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.84473932
53	Mineral absorption_Homo sapiens_hsa04978	0.82532356
54	ABC transporters_Homo sapiens_hsa02010	0.80139351
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77117896
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77021551
57	Butanoate metabolism_Homo sapiens_hsa00650	0.72599850
58	Retinol metabolism_Homo sapiens_hsa00830	0.72453631
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.72419077
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72227595
61	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.71966343
62	Folate biosynthesis_Homo sapiens_hsa00790	0.71478065
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70540028
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.68061700
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66514859
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65026499
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62034610
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61775929
69	Spliceosome_Homo sapiens_hsa03040	0.60768429
70	MAPK signaling pathway_Homo sapiens_hsa04010	0.59279018
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.59237771
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58978615
73	Base excision repair_Homo sapiens_hsa03410	0.58645089
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58102602
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.56333724
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55976213
77	Measles_Homo sapiens_hsa05162	0.54485629
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54167712
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.51640349
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49443619
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48779627
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47732370
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47726025
84	Metabolic pathways_Homo sapiens_hsa01100	0.46861202
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46000583
86	Glutathione metabolism_Homo sapiens_hsa00480	0.45476024
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43072872
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.42339723
89	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41002153
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37976739
91	Fatty acid degradation_Homo sapiens_hsa00071	0.37850378
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37738011
93	One carbon pool by folate_Homo sapiens_hsa00670	0.36889483
94	Fatty acid elongation_Homo sapiens_hsa00062	0.35739563
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35335944
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.33750629
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33401010
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.33340363
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.31627212
100	RNA transport_Homo sapiens_hsa03013	0.29693000

RPSAP40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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