ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.52526805
2	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.72730877
3	CENP-A containing nucleosome assembly (GO:0034080)	4.67380704
4	chromatin remodeling at centromere (GO:0031055)	4.66847024
5	coenzyme catabolic process (GO:0009109)	4.54846640
6	regulation of autophagic vacuole assembly (GO:2000785)	4.52290211
7	positive regulation of catecholamine secretion (GO:0033605)	4.36326773
8	histone exchange (GO:0043486)	4.35984209
9	regulation of oxidative stress-induced neuron death (GO:1903203)	4.18496549
10	melanin biosynthetic process (GO:0042438)	4.13667108
11	tongue development (GO:0043586)	4.12623888
12	DNA integration (GO:0015074)	4.04574691
13	melanin metabolic process (GO:0006582)	3.90238549
14	regulation of vacuole organization (GO:0044088)	3.82670123
15	activation of protein kinase B activity (GO:0032148)	3.80413026
16	mRNA cleavage (GO:0006379)	3.79454807
17	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.66020872
18	oligosaccharide biosynthetic process (GO:0009312)	3.62865288
19	secondary metabolite biosynthetic process (GO:0044550)	3.57887109
20	DNA replication-independent nucleosome organization (GO:0034724)	3.54775260
21	DNA replication-independent nucleosome assembly (GO:0006336)	3.54775260
22	kinetochore assembly (GO:0051382)	3.53625700
23	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.50577329
24	developmental pigmentation (GO:0048066)	3.47097589
25	protein polyglutamylation (GO:0018095)	3.45209501
26	negative regulation of telomere maintenance (GO:0032205)	3.33995359
27	DNA damage response, detection of DNA damage (GO:0042769)	3.29626098
28	resolution of meiotic recombination intermediates (GO:0000712)	3.23440734
29	regulation of sister chromatid cohesion (GO:0007063)	3.22341708
30	negative regulation of DNA binding (GO:0043392)	3.21063795
31	presynaptic membrane assembly (GO:0097105)	3.20096676
32	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.18970056
33	kinetochore organization (GO:0051383)	3.18468263
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.16268714
35	intraciliary transport (GO:0042073)	3.14940296
36	retinal rod cell development (GO:0046548)	3.11058994
37	histone H3-K36 demethylation (GO:0070544)	3.09211006
38	valine metabolic process (GO:0006573)	3.02608287
39	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.01877309
40	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.01653364
41	acrosome reaction (GO:0007340)	3.01292506
42	regulation of telomere maintenance (GO:0032204)	2.99277698
43	telomere maintenance via semi-conservative replication (GO:0032201)	2.98583375
44	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.96972992
45	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.92514675
46	rRNA catabolic process (GO:0016075)	2.89844418
47	limb bud formation (GO:0060174)	2.86466827
48	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.86430789
49	DNA catabolic process, exonucleolytic (GO:0000738)	2.83972269
50	RNA phosphodiester bond hydrolysis (GO:0090501)	2.83684400
51	regulation of helicase activity (GO:0051095)	2.82198948
52	pyrimidine nucleobase catabolic process (GO:0006208)	2.81230574
53	response to muscle activity (GO:0014850)	2.79691930
54	regulation of oxidative phosphorylation (GO:0002082)	2.77422935
55	short-term memory (GO:0007614)	2.77332054
56	protein localization to chromosome (GO:0034502)	2.71382277
57	mesenchymal-epithelial cell signaling (GO:0060638)	2.70271875
58	negative regulation of organelle assembly (GO:1902116)	2.68794432
59	microtubule severing (GO:0051013)	2.68017961
60	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.66839175
61	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.66565022
62	positive regulation of protein homodimerization activity (GO:0090073)	2.66152682
63	regulation of hippo signaling (GO:0035330)	2.65200154
64	replication fork processing (GO:0031297)	2.64362953
65	mitotic chromosome condensation (GO:0007076)	2.64172051
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58611651
67	neuron cell-cell adhesion (GO:0007158)	2.57926227
68	ATP-dependent chromatin remodeling (GO:0043044)	2.57691596
69	cell proliferation in forebrain (GO:0021846)	2.56628705
70	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.56504593
71	regulation of cellular respiration (GO:0043457)	2.56074525
72	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.54444968
73	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.54444968
74	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.54444968
75	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.54045806
76	DNA replication-dependent nucleosome assembly (GO:0006335)	2.53131279
77	DNA replication-dependent nucleosome organization (GO:0034723)	2.53131279
78	cornea development in camera-type eye (GO:0061303)	2.53126442
79	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.53060141
80	inositol phosphate catabolic process (GO:0071545)	2.49306683
81	regulation of coenzyme metabolic process (GO:0051196)	2.49170707
82	regulation of cofactor metabolic process (GO:0051193)	2.49170707
83	protein localization to cell surface (GO:0034394)	2.48608313
84	L-methionine biosynthetic process (GO:0071265)	2.48522459
85	amino acid salvage (GO:0043102)	2.48522459
86	L-methionine salvage (GO:0071267)	2.48522459
87	positive regulation of amine transport (GO:0051954)	2.47637700
88	glycosphingolipid biosynthetic process (GO:0006688)	2.47482272
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.47479066
90	protein-DNA complex assembly (GO:0065004)	2.47107778
91	histone H2A acetylation (GO:0043968)	2.46979310
92	regulation of dopamine secretion (GO:0014059)	2.45555171
93	radial glial cell differentiation (GO:0060019)	2.43677491
94	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.43562466
95	presynaptic membrane organization (GO:0097090)	2.42939521
96	telomere maintenance via recombination (GO:0000722)	2.42552671
97	regulation of exit from mitosis (GO:0007096)	2.42070965
98	DNA-dependent DNA replication (GO:0006261)	2.41968814
99	metallo-sulfur cluster assembly (GO:0031163)	2.40686451
100	iron-sulfur cluster assembly (GO:0016226)	2.40686451

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.50520612
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.05079289
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.24696824
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.96984447
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.46121337
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.44097317
7	GBX2_23144817_ChIP-Seq_PC3_Human	3.16112857
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03021907
9	EZH2_22144423_ChIP-Seq_EOC_Human	3.02020459
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.78934814
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.78785309
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.69595714
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.49373410
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.31936510
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12986710
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.10791110
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.09549054
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07698426
19	AR_21572438_ChIP-Seq_LNCaP_Human	2.02904209
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.99923581
21	EWS_26573619_Chip-Seq_HEK293_Human	1.98380385
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92469294
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92134629
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.90501322
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90127906
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89376901
27	FUS_26573619_Chip-Seq_HEK293_Human	1.88236606
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.88111724
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.86590813
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.77840389
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72756330
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.68323687
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.65351059
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.65277048
35	VDR_22108803_ChIP-Seq_LS180_Human	1.56339727
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51818951
37	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.50986041
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50638624
39	CIITA_25753668_ChIP-Seq_RAJI_Human	1.49832674
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45227640
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45144831
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.44979564
43	P300_19829295_ChIP-Seq_ESCs_Human	1.37976319
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37380939
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34743110
46	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.33519350
47	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.32586446
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32387956
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31975578
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31266878
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.31266878
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.30830983
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.28896444
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26762159
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25545471
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22682702
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16322731
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15904901
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15904901
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13495316
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11325203
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10914418
63	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10434084
64	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.09288471
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08593996
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08351980
67	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04958334
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00699364
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00060397
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99531849
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99164917
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99021619
73	AR_25329375_ChIP-Seq_VCAP_Human	0.98659391
74	STAT3_23295773_ChIP-Seq_U87_Human	0.97534481
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96808046
76	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.95599229
77	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94335360
78	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.94200120
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.93396081
80	SOX9_26525672_Chip-Seq_HEART_Mouse	0.93328337
81	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.90459780
82	KDM5A_27292631_Chip-Seq_BREAST_Human	0.89687631
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88874694
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.88653821
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.88523126
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.87815600
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87603431
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87121835
89	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86802777
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.86245358
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85834772
92	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84843656
93	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.83710014
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.83450968
95	TBL1_22424771_ChIP-Seq_293T_Human	0.82454494
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.82401610
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.81457639
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.81402131
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81286603
100	TCF4_23295773_ChIP-Seq_U87_Human	0.80484778

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.39123696
2	MP0004381_abnormal_hair_follicle	2.87440034
3	MP0001188_hyperpigmentation	2.66015136
4	MP0003315_abnormal_perineum_morphology	2.54263199
5	MP0006072_abnormal_retinal_apoptosis	2.45897655
6	MP0005075_abnormal_melanosome_morpholog	2.41198881
7	MP0003136_yellow_coat_color	2.34051606
8	MP0000749_muscle_degeneration	2.21337589
9	MP0000372_irregular_coat_pigmentation	2.20103942
10	MP0000015_abnormal_ear_pigmentation	2.18583352
11	MP0001984_abnormal_olfaction	2.04200617
12	MP0002735_abnormal_chemical_nociception	2.03248883
13	MP0006292_abnormal_olfactory_placode	2.02893773
14	MP0010094_abnormal_chromosome_stability	2.00691166
15	MP0008789_abnormal_olfactory_epithelium	1.83792156
16	MP0008058_abnormal_DNA_repair	1.81113961
17	MP0002822_catalepsy	1.79073242
18	MP0005499_abnormal_olfactory_system	1.77022594
19	MP0005394_taste/olfaction_phenotype	1.77022594
20	MP0001529_abnormal_vocalization	1.75384574
21	MP0002132_abnormal_respiratory_system	1.70052177
22	MP0001968_abnormal_touch/_nociception	1.69392287
23	MP0002736_abnormal_nociception_after	1.68839858
24	MP0001299_abnormal_eye_distance/	1.66351560
25	MP0001849_ear_inflammation	1.65998251
26	MP0002233_abnormal_nose_morphology	1.60553907
27	MP0002249_abnormal_larynx_morphology	1.59660724
28	MP0005171_absent_coat_pigmentation	1.56960194
29	MP0000049_abnormal_middle_ear	1.56561376
30	MP0009046_muscle_twitch	1.55626487
31	MP0003077_abnormal_cell_cycle	1.51543399
32	MP0003880_abnormal_central_pattern	1.51323350
33	MP0001905_abnormal_dopamine_level	1.49868154
34	MP0005174_abnormal_tail_pigmentation	1.49355445
35	MP0008877_abnormal_DNA_methylation	1.49137266
36	MP0006035_abnormal_mitochondrial_morpho	1.45227183
37	MP0004084_abnormal_cardiac_muscle	1.43179392
38	MP0003787_abnormal_imprinting	1.39042579
39	MP0005248_abnormal_Harderian_gland	1.38333407
40	MP0003693_abnormal_embryo_hatching	1.36472864
41	MP0003111_abnormal_nucleus_morphology	1.35462350
42	MP0000537_abnormal_urethra_morphology	1.34573666
43	MP0005253_abnormal_eye_physiology	1.31793957
44	MP0009697_abnormal_copulation	1.28304869
45	MP0002009_preneoplasia	1.28231895
46	MP0002095_abnormal_skin_pigmentation	1.27175774
47	MP0006036_abnormal_mitochondrial_physio	1.22191413
48	MP0008007_abnormal_cellular_replicative	1.20502484
49	MP0008004_abnormal_stomach_pH	1.20245889
50	MP0002160_abnormal_reproductive_system	1.19946275
51	MP0001485_abnormal_pinna_reflex	1.18336475
52	MP0003755_abnormal_palate_morphology	1.14618927
53	MP0002282_abnormal_trachea_morphology	1.13676308
54	MP0005187_abnormal_penis_morphology	1.11253370
55	MP0003938_abnormal_ear_development	1.09852432
56	MP0005410_abnormal_fertilization	1.09366263
57	MP0004742_abnormal_vestibular_system	1.09054383
58	MP0001486_abnormal_startle_reflex	1.08390025
59	MP0003635_abnormal_synaptic_transmissio	1.07996154
60	MP0004924_abnormal_behavior	1.07416983
61	MP0005386_behavior/neurological_phenoty	1.07416983
62	MP0005646_abnormal_pituitary_gland	1.07149608
63	MP0000778_abnormal_nervous_system	1.06964554
64	MP0002837_dystrophic_cardiac_calcinosis	1.06706557
65	MP0009250_abnormal_appendicular_skeleto	1.04098599
66	MP0004859_abnormal_synaptic_plasticity	1.03993910
67	MP0002184_abnormal_innervation	1.03330713
68	MP0003806_abnormal_nucleotide_metabolis	1.01257973
69	MP0002272_abnormal_nervous_system	1.00916928
70	MP0001270_distended_abdomen	1.00300253
71	MP0009384_cardiac_valve_regurgitation	0.99487343
72	MP0003718_maternal_effect	0.98553710
73	MP0004811_abnormal_neuron_physiology	0.97736352
74	MP0003567_abnormal_fetal_cardiomyocyte	0.96013292
75	MP0005391_vision/eye_phenotype	0.95773098
76	MP0010386_abnormal_urinary_bladder	0.94882529
77	MP0001986_abnormal_taste_sensitivity	0.94240957
78	MP0003385_abnormal_body_wall	0.93717374
79	MP0009745_abnormal_behavioral_response	0.92941823
80	MP0002752_abnormal_somatic_nervous	0.92008934
81	MP0003698_abnormal_male_reproductive	0.91672856
82	MP0002177_abnormal_outer_ear	0.88273456
83	MP0002234_abnormal_pharynx_morphology	0.88266005
84	MP0003935_abnormal_craniofacial_develop	0.87522402
85	MP0008770_decreased_survivor_rate	0.85463414
86	MP0008932_abnormal_embryonic_tissue	0.85382059
87	MP0002751_abnormal_autonomic_nervous	0.85379640
88	MP0010368_abnormal_lymphatic_system	0.85158801
89	MP0000467_abnormal_esophagus_morphology	0.85030206
90	MP0001502_abnormal_circadian_rhythm	0.84989293
91	MP0001324_abnormal_eye_pigmentation	0.81406911
92	MP0005551_abnormal_eye_electrophysiolog	0.80873920
93	MP0001340_abnormal_eyelid_morphology	0.79022770
94	MP0000631_abnormal_neuroendocrine_gland	0.78497634
95	MP0001661_extended_life_span	0.78019697
96	MP0010030_abnormal_orbit_morphology	0.77661218
97	MP0000026_abnormal_inner_ear	0.77252850
98	MP0004885_abnormal_endolymph	0.77121775
99	MP0001929_abnormal_gametogenesis	0.76412749
100	MP0000747_muscle_weakness	0.76395533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the columella (HP:0009929)	4.43007105
2	High anterior hairline (HP:0009890)	3.91652577
3	Reduced antithrombin III activity (HP:0001976)	3.52327747
4	Broad-based gait (HP:0002136)	3.35343995
5	Inability to walk (HP:0002540)	3.34418207
6	Absent speech (HP:0001344)	3.00387052
7	Focal motor seizures (HP:0011153)	2.96244012
8	Type II lissencephaly (HP:0007260)	2.89081645
9	Clumsiness (HP:0002312)	2.85125955
10	Retinal dysplasia (HP:0007973)	2.84050757
11	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.80832747
12	Median cleft lip (HP:0000161)	2.61398013
13	Conical tooth (HP:0000698)	2.60309900
14	Broad face (HP:0000283)	2.59243753
15	Hyperventilation (HP:0002883)	2.58904199
16	Urinary urgency (HP:0000012)	2.58097126
17	Cerebral hypomyelination (HP:0006808)	2.53892027
18	Progressive inability to walk (HP:0002505)	2.51745768
19	B lymphocytopenia (HP:0010976)	2.44530308
20	Hypoplastic pelvis (HP:0008839)	2.42813737
21	Intestinal atresia (HP:0011100)	2.42612624
22	Cerebellar dysplasia (HP:0007033)	2.39948176
23	Volvulus (HP:0002580)	2.39135503
24	Agammaglobulinemia (HP:0004432)	2.34699397
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.28595820
26	Absent/shortened dynein arms (HP:0200106)	2.28595820
27	Oligodactyly (hands) (HP:0001180)	2.28350395
28	Hip dysplasia (HP:0001385)	2.26008218
29	Lissencephaly (HP:0001339)	2.25143995
30	Self-mutilation (HP:0000742)	2.23947038
31	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.22521368
32	Renal cortical cysts (HP:0000803)	2.21147665
33	Drooling (HP:0002307)	2.20347284
34	Atonic seizures (HP:0010819)	2.18913085
35	Facial hemangioma (HP:0000329)	2.18641881
36	Aplasia/hypoplasia of the uterus (HP:0008684)	2.17996084
37	Abnormality of lateral ventricle (HP:0030047)	2.16781331
38	Acute lymphatic leukemia (HP:0006721)	2.08249218
39	Amblyopia (HP:0000646)	2.07200652
40	Hypoplastic nipples (HP:0002557)	2.06870977
41	Molar tooth sign on MRI (HP:0002419)	2.04615737
42	Abnormality of midbrain morphology (HP:0002418)	2.04615737
43	Chronic sinusitis (HP:0011109)	2.04612173
44	Abnormality of the shoulder girdle musculature (HP:0001435)	2.03664680
45	Abnormality of B cell number (HP:0010975)	2.02533241
46	Aplastic anemia (HP:0001915)	2.01812279
47	Excessive salivation (HP:0003781)	2.01522345
48	Broad distal phalanx of finger (HP:0009836)	2.00118774
49	Poor head control (HP:0002421)	1.97926548
50	Abnormality of the frontal sinuses (HP:0002687)	1.97232658
51	Sensory axonal neuropathy (HP:0003390)	1.97193541
52	Unsteady gait (HP:0002317)	1.96687468
53	Eosinophilia (HP:0001880)	1.96346796
54	Poor eye contact (HP:0000817)	1.93907692
55	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.93550363
56	Protruding tongue (HP:0010808)	1.93070852
57	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.85625825
58	Hypoplasia of the brainstem (HP:0002365)	1.85625825
59	Thickened helices (HP:0000391)	1.85222820
60	Cupped ear (HP:0000378)	1.83295777
61	Focal seizures (HP:0007359)	1.81118689
62	True hermaphroditism (HP:0010459)	1.80415914
63	Small hand (HP:0200055)	1.80401836
64	Panhypogammaglobulinemia (HP:0003139)	1.79685818
65	Fibular aplasia (HP:0002990)	1.79382350
66	Spinal rigidity (HP:0003306)	1.78538236
67	Benign neoplasm of the central nervous system (HP:0100835)	1.76756364
68	Tubulointerstitial nephritis (HP:0001970)	1.76282115
69	Hypoplasia of the uterus (HP:0000013)	1.75933056
70	Narrow forehead (HP:0000341)	1.74537916
71	Nephronophthisis (HP:0000090)	1.73690452
72	Progressive macrocephaly (HP:0004481)	1.72171408
73	Submucous cleft hard palate (HP:0000176)	1.70214717
74	Widely spaced teeth (HP:0000687)	1.69897305
75	Gastrointestinal atresia (HP:0002589)	1.69554854
76	Optic nerve hypoplasia (HP:0000609)	1.69479558
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.69208195
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.69208195
79	Abnormal protein glycosylation (HP:0012346)	1.69208195
80	Abnormal glycosylation (HP:0012345)	1.69208195
81	Aortic aneurysm (HP:0004942)	1.69127749
82	Aplasia cutis congenita (HP:0001057)	1.67783513
83	Anophthalmia (HP:0000528)	1.65455385
84	Rimmed vacuoles (HP:0003805)	1.64521178
85	Acute necrotizing encephalopathy (HP:0006965)	1.64215914
86	Postaxial hand polydactyly (HP:0001162)	1.64100227
87	Abnormality of the calf musculature (HP:0001430)	1.62709855
88	Bifid tongue (HP:0010297)	1.62371992
89	Opisthotonus (HP:0002179)	1.62102050
90	Meningioma (HP:0002858)	1.61826512
91	Oligodactyly (HP:0012165)	1.61695218
92	Calf muscle hypertrophy (HP:0008981)	1.59352983
93	Carpal bone hypoplasia (HP:0001498)	1.57823912
94	Proximal amyotrophy (HP:0007126)	1.57637898
95	Epileptic encephalopathy (HP:0200134)	1.56818293
96	Iris hypopigmentation (HP:0007730)	1.56719320
97	Pancreatic cysts (HP:0001737)	1.56477075
98	Absence seizures (HP:0002121)	1.56425680
99	Ocular albinism (HP:0001107)	1.56121771
100	Exercise-induced muscle cramps (HP:0003710)	1.55826912

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.81599256
2	NEK2	4.10729925
3	LATS1	3.43914837
4	MAP2K7	3.43842081
5	MARK3	3.07033443
6	CSNK1A1L	2.60685394
7	TLK1	2.56191991
8	CSNK1G3	2.47587943
9	EIF2AK3	2.38638435
10	FRK	2.27556305
11	CSNK1G2	2.23613225
12	EPHA3	2.05090641
13	CSNK1G1	1.94209897
14	CDK3	1.88279520
15	SIK2	1.79157189
16	CDC7	1.74790356
17	CASK	1.66685125
18	STK38L	1.58350035
19	OBSCN	1.56113932
20	DYRK2	1.54932583
21	BMPR1B	1.53577012
22	MAP3K4	1.53199116
23	DYRK3	1.48194288
24	WEE1	1.41406705
25	ZAK	1.41385612
26	SRPK1	1.37880168
27	TRIM28	1.34173533
28	ERBB3	1.30870245
29	BCR	1.27093984
30	MAPK13	1.26933535
31	MARK1	1.22968003
32	WNK3	1.22297978
33	CCNB1	1.21475346
34	RPS6KA4	1.15054617
35	ARAF	1.09111766
36	VRK1	1.08706857
37	PLK1	1.07401025
38	SIK3	1.02956526
39	STK3	1.01893414
40	MYLK	1.01435359
41	STK38	0.98294715
42	TAOK1	0.97947316
43	AURKB	0.96279508
44	BRD4	0.94278772
45	PKN1	0.91879370
46	PLK4	0.87580665
47	CDK8	0.86183736
48	TGFBR1	0.82557927
49	NME2	0.82242812
50	PLK3	0.77070958
51	GRK6	0.76170123
52	CDK14	0.69692359
53	PRKCE	0.69472872
54	SGK494	0.66583457
55	SGK223	0.66583457
56	UHMK1	0.63583360
57	EIF2AK1	0.60318531
58	STK4	0.58886485
59	AKT3	0.56638359
60	RPS6KA5	0.56551494
61	MINK1	0.56450792
62	ATR	0.54811615
63	TGFBR2	0.54675702
64	PBK	0.54405063
65	ATM	0.54363253
66	RAF1	0.54077685
67	PAK1	0.52291196
68	PRKCQ	0.51563871
69	CDK5	0.51132154
70	LATS2	0.50112076
71	BRAF	0.49132064
72	CHEK2	0.48610811
73	CSNK1D	0.48214444
74	GRK5	0.47934977
75	MKNK1	0.47304399
76	MAP3K5	0.46496077
77	MAP2K4	0.46199766
78	ILK	0.44913632
79	RPS6KB1	0.44180338
80	PAK3	0.43120537
81	NME1	0.42070199
82	KSR1	0.41610101
83	CAMK2B	0.39919142
84	NEK1	0.39661328
85	MAP3K8	0.37106536
86	PLK2	0.35848840
87	CDK1	0.35266557
88	CSNK1A1	0.35048515
89	MAPK12	0.34912280
90	GRK1	0.33300628
91	FGR	0.33120644
92	CAMK4	0.31466940
93	BTK	0.31071936
94	PRKCG	0.30561840
95	BCKDK	0.29778946
96	DAPK3	0.29616654
97	PTK2B	0.27625868
98	SGK2	0.27475658
99	MAP4K2	0.27178258
100	CAMK2D	0.26656070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.14031715
2	Olfactory transduction_Homo sapiens_hsa04740	2.90527734
3	DNA replication_Homo sapiens_hsa03030	2.86520645
4	Base excision repair_Homo sapiens_hsa03410	2.54345243
5	Proteasome_Homo sapiens_hsa03050	2.49658856
6	Phototransduction_Homo sapiens_hsa04744	2.41402319
7	Mismatch repair_Homo sapiens_hsa03430	2.14893580
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.10185340
9	Basal transcription factors_Homo sapiens_hsa03022	2.09438963
10	RNA degradation_Homo sapiens_hsa03018	2.00129492
11	Pyrimidine metabolism_Homo sapiens_hsa00240	1.98738548
12	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.96136291
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.95873306
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92093994
15	Homologous recombination_Homo sapiens_hsa03440	1.85326035
16	Oocyte meiosis_Homo sapiens_hsa04114	1.84637971
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.82993727
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80327116
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.73165880
20	RNA polymerase_Homo sapiens_hsa03020	1.65832779
21	Circadian entrainment_Homo sapiens_hsa04713	1.60318887
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.50216928
23	Sulfur relay system_Homo sapiens_hsa04122	1.48613657
24	RNA transport_Homo sapiens_hsa03013	1.43990679
25	Butanoate metabolism_Homo sapiens_hsa00650	1.33165648
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28243641
27	Propanoate metabolism_Homo sapiens_hsa00640	1.26297230
28	Alcoholism_Homo sapiens_hsa05034	1.25854977
29	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.25026940
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.24998933
31	Purine metabolism_Homo sapiens_hsa00230	1.22712676
32	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.22614247
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20619855
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.19671353
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.18085992
36	Melanogenesis_Homo sapiens_hsa04916	1.17766652
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.16516936
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.13605115
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.04992796
40	Melanoma_Homo sapiens_hsa05218	1.03968739
41	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.02935185
42	Cell cycle_Homo sapiens_hsa04110	1.02402689
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00519252
44	Protein export_Homo sapiens_hsa03060	0.99714874
45	Wnt signaling pathway_Homo sapiens_hsa04310	0.99674130
46	Gap junction_Homo sapiens_hsa04540	0.98712525
47	Spliceosome_Homo sapiens_hsa03040	0.97818276
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.93681745
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90735291
50	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.90178686
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.87838701
52	Hippo signaling pathway_Homo sapiens_hsa04390	0.86488308
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83719076
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.82927645
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.81751595
56	Nicotine addiction_Homo sapiens_hsa05033	0.79569294
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77667702
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.76909465
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.76783570
60	Circadian rhythm_Homo sapiens_hsa04710	0.74688243
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74684145
62	Amphetamine addiction_Homo sapiens_hsa05031	0.73468777
63	Prostate cancer_Homo sapiens_hsa05215	0.72010179
64	Glioma_Homo sapiens_hsa05214	0.71138068
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.69864314
66	Renin secretion_Homo sapiens_hsa04924	0.68837165
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68209101
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.68018533
69	GABAergic synapse_Homo sapiens_hsa04727	0.66001527
70	Salivary secretion_Homo sapiens_hsa04970	0.63197403
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.62828960
72	Long-term depression_Homo sapiens_hsa04730	0.62282627
73	Taste transduction_Homo sapiens_hsa04742	0.59829701
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56027234
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54876557
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54852014
77	Folate biosynthesis_Homo sapiens_hsa00790	0.52907120
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52232441
79	Hepatitis B_Homo sapiens_hsa05161	0.50203225
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.49827442
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49363095
82	Endometrial cancer_Homo sapiens_hsa05213	0.47527794
83	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.46979453
84	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.45615410
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44997632
86	Long-term potentiation_Homo sapiens_hsa04720	0.44705139
87	Axon guidance_Homo sapiens_hsa04360	0.44602907
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.42922435
89	Parkinsons disease_Homo sapiens_hsa05012	0.38908989
90	Metabolic pathways_Homo sapiens_hsa01100	0.38469370
91	Cholinergic synapse_Homo sapiens_hsa04725	0.37193852
92	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35304341
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34686269
94	Small cell lung cancer_Homo sapiens_hsa05222	0.34646860
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34472074
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32980304
97	Gastric acid secretion_Homo sapiens_hsa04971	0.32618652
98	Non-small cell lung cancer_Homo sapiens_hsa05223	0.32215557
99	Morphine addiction_Homo sapiens_hsa05032	0.32067246
100	Adherens junction_Homo sapiens_hsa04520	0.31677272

RPSAP41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »