RPSAP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.51868705
2ribosomal small subunit assembly (GO:0000028)5.37814016
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.03345241
4ATP synthesis coupled proton transport (GO:0015986)5.02090956
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.02090956
6ribosomal small subunit biogenesis (GO:0042274)4.69344589
7viral transcription (GO:0019083)4.66780159
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63148197
9behavioral response to nicotine (GO:0035095)4.62502241
10response to pheromone (GO:0019236)4.62003182
11translational termination (GO:0006415)4.56391535
12maturation of SSU-rRNA (GO:0030490)4.28971072
13protein neddylation (GO:0045116)4.28304151
14DNA deamination (GO:0045006)4.06283606
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05042184
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99642090
17cotranslational protein targeting to membrane (GO:0006613)3.95688557
18protein targeting to ER (GO:0045047)3.92884306
19translational elongation (GO:0006414)3.83891400
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.80076805
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78547086
22peptidyl-histidine modification (GO:0018202)3.74803288
23protein localization to endoplasmic reticulum (GO:0070972)3.68597209
24respiratory electron transport chain (GO:0022904)3.63345130
25electron transport chain (GO:0022900)3.61497461
26DNA double-strand break processing (GO:0000729)3.61001221
27respiratory chain complex IV assembly (GO:0008535)3.53506740
28cellular protein complex disassembly (GO:0043624)3.52482479
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51413557
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.51413557
31NADH dehydrogenase complex assembly (GO:0010257)3.51413557
32translational initiation (GO:0006413)3.50076628
33protein complex biogenesis (GO:0070271)3.44645663
34translation (GO:0006412)3.31722839
35replication fork processing (GO:0031297)3.31722712
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30703761
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30451523
38pseudouridine synthesis (GO:0001522)3.29674742
39viral life cycle (GO:0019058)3.28071782
40axonemal dynein complex assembly (GO:0070286)3.27757680
41mitochondrial respiratory chain complex assembly (GO:0033108)3.19979125
42pyrimidine nucleotide catabolic process (GO:0006244)3.11411128
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11309198
44base-excision repair, AP site formation (GO:0006285)3.06907378
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06058211
46protein complex disassembly (GO:0043241)3.05882153
47cytochrome complex assembly (GO:0017004)3.05356536
48macromolecular complex disassembly (GO:0032984)2.99980103
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96000733
50ATP biosynthetic process (GO:0006754)2.94513963
51intracellular protein transmembrane import (GO:0044743)2.93633507
52hydrogen ion transmembrane transport (GO:1902600)2.90470133
53inositol phosphate catabolic process (GO:0071545)2.89576934
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89077003
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89077003
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86593880
57ubiquinone biosynthetic process (GO:0006744)2.85707233
58water-soluble vitamin biosynthetic process (GO:0042364)2.83426722
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82913649
60transcription elongation from RNA polymerase III promoter (GO:0006385)2.82085483
61termination of RNA polymerase III transcription (GO:0006386)2.82085483
62proteasome assembly (GO:0043248)2.81452391
63protein-cofactor linkage (GO:0018065)2.80993616
64purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80652441
65inositol phosphate dephosphorylation (GO:0046855)2.76629871
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76629871
67epithelial cilium movement (GO:0003351)2.76472803
68cellular component biogenesis (GO:0044085)2.76085674
69L-serine metabolic process (GO:0006563)2.72046401
70chromatin remodeling at centromere (GO:0031055)2.71798575
71proton transport (GO:0015992)2.71536412
72cilium movement (GO:0003341)2.71282675
73ribosomal large subunit biogenesis (GO:0042273)2.70667492
74ncRNA catabolic process (GO:0034661)2.70316546
75regulation of collateral sprouting (GO:0048670)2.67060496
76hydrogen transport (GO:0006818)2.66504083
77organelle disassembly (GO:1903008)2.65743502
78protein targeting to membrane (GO:0006612)2.63185984
79resolution of meiotic recombination intermediates (GO:0000712)2.61553460
80pyrimidine nucleobase catabolic process (GO:0006208)2.61523337
81ribonucleoprotein complex biogenesis (GO:0022613)2.61170451
82protein polyglutamylation (GO:0018095)2.60104069
83myoblast migration (GO:0051451)2.59711501
84ubiquinone metabolic process (GO:0006743)2.58598687
85negative regulation of telomere maintenance (GO:0032205)2.58562523
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.54216681
87ribonucleoside triphosphate biosynthetic process (GO:0009201)2.53995848
88tongue development (GO:0043586)2.53814587
89regulation of cilium movement (GO:0003352)2.53813904
90cell proliferation in forebrain (GO:0021846)2.50781667
91pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50317871
92nonmotile primary cilium assembly (GO:0035058)2.48302935
93rRNA processing (GO:0006364)2.47776240
94RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.46984146
95tRNA processing (GO:0008033)2.46313331
96GTP biosynthetic process (GO:0006183)2.46179322
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45660027
98L-methionine salvage (GO:0071267)2.45634925
99L-methionine biosynthetic process (GO:0071265)2.45634925
100amino acid salvage (GO:0043102)2.45634925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.32425981
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68074777
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.53339548
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34591579
5ZNF274_21170338_ChIP-Seq_K562_Hela3.19997832
6VDR_22108803_ChIP-Seq_LS180_Human3.01264981
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89384724
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.72165317
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63216260
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62846354
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46353042
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.39116533
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32480474
14EWS_26573619_Chip-Seq_HEK293_Human2.22780380
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21556590
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15148260
17GBX2_23144817_ChIP-Seq_PC3_Human2.01457828
18MYC_18940864_ChIP-ChIP_HL60_Human1.96436974
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88498086
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86762130
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86747939
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84719034
23FUS_26573619_Chip-Seq_HEK293_Human1.80200470
24IRF1_19129219_ChIP-ChIP_H3396_Human1.75305104
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74045787
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.71454324
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59936559
28VDR_23849224_ChIP-Seq_CD4+_Human1.59841557
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57935997
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52026319
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50530675
32ELK1_19687146_ChIP-ChIP_HELA_Human1.49091004
33FOXP3_21729870_ChIP-Seq_TREG_Human1.46700742
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44354727
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43979217
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42049739
37P300_19829295_ChIP-Seq_ESCs_Human1.41998569
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41811169
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40866896
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40599205
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39523480
42TP53_22573176_ChIP-Seq_HFKS_Human1.35488558
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.33318258
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.33075772
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31545530
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.31211233
47GABP_19822575_ChIP-Seq_HepG2_Human1.29301077
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.26609154
49IGF1R_20145208_ChIP-Seq_DFB_Human1.25631105
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23383172
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23285103
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23144258
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.22717100
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21174473
55NCOR_22424771_ChIP-Seq_293T_Human1.19187576
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17809940
57REST_21632747_ChIP-Seq_MESCs_Mouse1.17423421
58TTF2_22483619_ChIP-Seq_HELA_Human1.16186512
59RNF2_27304074_Chip-Seq_NSC_Mouse1.14497320
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.13013100
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12233745
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10266874
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.08705556
64NANOG_20526341_ChIP-Seq_ESCs_Human1.05613477
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05372794
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04980370
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.04589114
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04084695
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03946410
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03591456
71NANOG_19829295_ChIP-Seq_ESCs_Human1.02663733
72SOX2_19829295_ChIP-Seq_ESCs_Human1.02663733
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02501660
74XRN2_22483619_ChIP-Seq_HELA_Human1.02032486
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01890296
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01718156
77CBP_20019798_ChIP-Seq_JUKART_Human1.01718156
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.00372336
79MYC_19829295_ChIP-Seq_ESCs_Human0.99825820
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99767717
81PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98569823
82ER_23166858_ChIP-Seq_MCF-7_Human0.97760430
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.96272944
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95962937
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95541669
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93562130
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92472300
88AR_20517297_ChIP-Seq_VCAP_Human0.89053356
89TAF2_19829295_ChIP-Seq_ESCs_Human0.88862891
90ERA_21632823_ChIP-Seq_H3396_Human0.88498667
91BCAT_22108803_ChIP-Seq_LS180_Human0.87123719
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86847312
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.85873492
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85873492
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85332650
96TCF4_22108803_ChIP-Seq_LS180_Human0.84614690
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84115690
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83570479
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.83397512
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.83315395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.82500356
2MP0008877_abnormal_DNA_methylation3.28065313
3MP0001984_abnormal_olfaction3.05556413
4MP0009379_abnormal_foot_pigmentation3.02269103
5MP0003787_abnormal_imprinting2.47645183
6MP0002102_abnormal_ear_morphology2.46253575
7MP0008789_abnormal_olfactory_epithelium2.43445106
8MP0003122_maternal_imprinting2.30110300
9MP0005499_abnormal_olfactory_system2.10399636
10MP0005394_taste/olfaction_phenotype2.10399636
11MP0001293_anophthalmia2.07004264
12MP0001968_abnormal_touch/_nociception1.98001067
13MP0002736_abnormal_nociception_after1.94773421
14MP0001485_abnormal_pinna_reflex1.91914317
15MP0008058_abnormal_DNA_repair1.88871466
16MP0003121_genomic_imprinting1.87836962
17MP0004142_abnormal_muscle_tone1.81735857
18MP0001529_abnormal_vocalization1.74582998
19MP0000778_abnormal_nervous_system1.74209812
20MP0002653_abnormal_ependyma_morphology1.72238787
21MP0005646_abnormal_pituitary_gland1.70049345
22MP0003136_yellow_coat_color1.69954667
23MP0002638_abnormal_pupillary_reflex1.68723913
24MP0006276_abnormal_autonomic_nervous1.64109365
25MP0002938_white_spotting1.62874203
26MP0006072_abnormal_retinal_apoptosis1.61211667
27MP0005551_abnormal_eye_electrophysiolog1.59782247
28MP0009745_abnormal_behavioral_response1.58730682
29MP0002272_abnormal_nervous_system1.58402831
30MP0003718_maternal_effect1.53619730
31MP0005084_abnormal_gallbladder_morpholo1.44218554
32MP0000049_abnormal_middle_ear1.44030608
33MP0003646_muscle_fatigue1.43719829
34MP0004885_abnormal_endolymph1.42872598
35MP0004133_heterotaxia1.42058047
36MP0008872_abnormal_physiological_respon1.41715362
37MP0003890_abnormal_embryonic-extraembry1.40281701
38MP0001188_hyperpigmentation1.38602170
39MP0002837_dystrophic_cardiac_calcinosis1.37159318
40MP0001905_abnormal_dopamine_level1.36902264
41MP0000631_abnormal_neuroendocrine_gland1.36830698
42MP0003567_abnormal_fetal_cardiomyocyte1.34665519
43MP0009046_muscle_twitch1.34128606
44MP0005377_hearing/vestibular/ear_phenot1.28660063
45MP0003878_abnormal_ear_physiology1.28660063
46MP0002160_abnormal_reproductive_system1.26738572
47MP0003123_paternal_imprinting1.21736312
48MP0003315_abnormal_perineum_morphology1.18413320
49MP0004145_abnormal_muscle_electrophysio1.17035907
50MP0008875_abnormal_xenobiotic_pharmacok1.16531044
51MP0002572_abnormal_emotion/affect_behav1.13863736
52MP0002557_abnormal_social/conspecific_i1.12924091
53MP0001486_abnormal_startle_reflex1.12605265
54MP0005410_abnormal_fertilization1.11809282
55MP0004742_abnormal_vestibular_system1.11602625
56MP0003937_abnormal_limbs/digits/tail_de1.10417438
57MP0003186_abnormal_redox_activity1.07921692
58MP0002277_abnormal_respiratory_mucosa1.07921657
59MP0005379_endocrine/exocrine_gland_phen1.07663149
60MP0003635_abnormal_synaptic_transmissio1.07530833
61MP0005187_abnormal_penis_morphology1.07292120
62MP0002752_abnormal_somatic_nervous1.06397243
63MP0002210_abnormal_sex_determination1.05022835
64MP0005195_abnormal_posterior_eye1.03128726
65MP0006035_abnormal_mitochondrial_morpho1.01857640
66MP0002063_abnormal_learning/memory/cond0.98946751
67MP0002733_abnormal_thermal_nociception0.98859443
68MP0002163_abnormal_gland_morphology0.98210154
69MP0001970_abnormal_pain_threshold0.98021619
70MP0005253_abnormal_eye_physiology0.98019795
71MP0003880_abnormal_central_pattern0.97675052
72MP0005389_reproductive_system_phenotype0.96290219
73MP0010030_abnormal_orbit_morphology0.95688609
74MP0002184_abnormal_innervation0.94356770
75MP0003693_abnormal_embryo_hatching0.94313798
76MP0002233_abnormal_nose_morphology0.93720616
77MP0000516_abnormal_urinary_system0.93417677
78MP0005367_renal/urinary_system_phenotyp0.93417677
79MP0001348_abnormal_lacrimal_gland0.93089468
80MP0000955_abnormal_spinal_cord0.90986835
81MP0003786_premature_aging0.90932987
82MP0002067_abnormal_sensory_capabilities0.89377412
83MP0009053_abnormal_anal_canal0.88041880
84MP0001986_abnormal_taste_sensitivity0.88008195
85MP0002064_seizures0.87898168
86MP0003698_abnormal_male_reproductive0.87768839
87MP0003938_abnormal_ear_development0.86921214
88MP0000566_synostosis0.86377250
89MP0000372_irregular_coat_pigmentation0.86331147
90MP0003011_delayed_dark_adaptation0.86296923
91MP0001929_abnormal_gametogenesis0.86259874
92MP0003119_abnormal_digestive_system0.86041215
93MP0002735_abnormal_chemical_nociception0.85324191
94MP0001177_atelectasis0.84804795
95MP0000026_abnormal_inner_ear0.84348817
96MP0004859_abnormal_synaptic_plasticity0.84161396
97MP0006036_abnormal_mitochondrial_physio0.82917388
98MP0004147_increased_porphyrin_level0.80657504
99MP0001440_abnormal_grooming_behavior0.80408452
100MP0004924_abnormal_behavior0.79374896

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.98640616
2Progressive macrocephaly (HP:0004481)3.67484437
3Acute encephalopathy (HP:0006846)3.59450840
4Abnormality of the labia minora (HP:0012880)3.49930992
5Abnormal mitochondria in muscle tissue (HP:0008316)3.46290740
6Molar tooth sign on MRI (HP:0002419)3.42806144
7Abnormality of midbrain morphology (HP:0002418)3.42806144
8Mitochondrial inheritance (HP:0001427)3.42530861
9Increased hepatocellular lipid droplets (HP:0006565)3.35335348
10Pancreatic fibrosis (HP:0100732)3.34414526
11Septo-optic dysplasia (HP:0100842)3.30391318
12Reticulocytopenia (HP:0001896)3.26755399
13Increased CSF lactate (HP:0002490)3.20263416
14Lipid accumulation in hepatocytes (HP:0006561)3.13592495
15Pancreatic cysts (HP:0001737)3.10182280
16Renal Fanconi syndrome (HP:0001994)3.04684803
17Supernumerary spleens (HP:0009799)2.88523017
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88147919
19True hermaphroditism (HP:0010459)2.82262880
20Abnormal rod and cone electroretinograms (HP:0008323)2.77138048
21Congenital stationary night blindness (HP:0007642)2.69161116
22Abnormal respiratory motile cilium physiology (HP:0012261)2.65788900
23Abnormal ciliary motility (HP:0012262)2.62447142
24Macrocytic anemia (HP:0001972)2.59846029
25Type 2 muscle fiber atrophy (HP:0003554)2.59463746
26Absent thumb (HP:0009777)2.58029733
27Cerebral edema (HP:0002181)2.55501573
28Abnormality of cells of the erythroid lineage (HP:0012130)2.50775985
29Absent/shortened dynein arms (HP:0200106)2.46324072
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.46324072
31Optic disc pallor (HP:0000543)2.44849167
32Absent septum pellucidum (HP:0001331)2.43918429
33Increased serum lactate (HP:0002151)2.43851813
34Abnormal respiratory epithelium morphology (HP:0012253)2.42731081
35Abnormal respiratory motile cilium morphology (HP:0005938)2.42731081
36Hepatocellular necrosis (HP:0001404)2.42497277
37Hyperglycinemia (HP:0002154)2.42460179
38Colon cancer (HP:0003003)2.42178857
39Chronic hepatic failure (HP:0100626)2.39355997
40Nephronophthisis (HP:0000090)2.38090753
41Sclerocornea (HP:0000647)2.38082772
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.36782643
43Increased intramyocellular lipid droplets (HP:0012240)2.31785019
44Muscle fiber atrophy (HP:0100295)2.30994289
45Medial flaring of the eyebrow (HP:0010747)2.30992571
46Abolished electroretinogram (ERG) (HP:0000550)2.30939309
473-Methylglutaconic aciduria (HP:0003535)2.27789721
48Abnormality of the septum pellucidum (HP:0007375)2.25776915
49Occipital encephalocele (HP:0002085)2.25707664
50Poor suck (HP:0002033)2.25624466
51Anencephaly (HP:0002323)2.18911314
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.17776604
53Lactic acidosis (HP:0003128)2.16476420
54Asplenia (HP:0001746)2.15951749
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15577214
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.12574692
57Exertional dyspnea (HP:0002875)2.12197044
58Stenosis of the external auditory canal (HP:0000402)2.09056413
59Retinal dysplasia (HP:0007973)2.05468203
60Optic nerve hypoplasia (HP:0000609)2.04536257
61Hepatic necrosis (HP:0002605)2.04214654
62Pendular nystagmus (HP:0012043)2.03157410
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00994067
64Abnormal drinking behavior (HP:0030082)1.98520664
65Polydipsia (HP:0001959)1.98520664
66Meckel diverticulum (HP:0002245)1.98034470
67Abnormal number of erythroid precursors (HP:0012131)1.97127658
68Pallor (HP:0000980)1.96932496
69Gait imbalance (HP:0002141)1.96921281
70Polyphagia (HP:0002591)1.95253833
71Abnormality of the ileum (HP:0001549)1.93533385
72Cystic liver disease (HP:0006706)1.90051649
73Abnormality of the renal medulla (HP:0100957)1.89012485
74Neoplasm of the adrenal cortex (HP:0100641)1.88162329
75Increased muscle lipid content (HP:0009058)1.88136982
76Abnormality of renal resorption (HP:0011038)1.87909611
77Hyperthyroidism (HP:0000836)1.87807871
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.87330308
79Lethargy (HP:0001254)1.86564948
80Rib fusion (HP:0000902)1.85875648
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84161928
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82746673
83Congenital primary aphakia (HP:0007707)1.82631688
84Hyperphosphaturia (HP:0003109)1.82532188
85Genital tract atresia (HP:0001827)1.81558296
86Respiratory failure (HP:0002878)1.81498193
87Abnormality of serum amino acid levels (HP:0003112)1.81338476
88Abnormal number of incisors (HP:0011064)1.80899056
89Narrow forehead (HP:0000341)1.79651154
90Triphalangeal thumb (HP:0001199)1.78313390
91Vaginal atresia (HP:0000148)1.76591339
92Pachygyria (HP:0001302)1.76079723
93Postaxial foot polydactyly (HP:0001830)1.74854149
94Abnormality of alanine metabolism (HP:0010916)1.74339768
95Hyperalaninemia (HP:0003348)1.74339768
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74339768
97Male pseudohermaphroditism (HP:0000037)1.74111950
98Optic nerve coloboma (HP:0000588)1.73600935
99Bile duct proliferation (HP:0001408)1.73152204
100Abnormal biliary tract physiology (HP:0012439)1.73152204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.95596438
2PINK13.27835562
3WNK43.14957138
4ZAK2.48276102
5DYRK22.47443716
6WNK32.44292663
7STK162.24819861
8BCKDK2.16891253
9BMPR1B2.09991546
10ADRBK22.01971532
11TNIK1.91132829
12STK391.90750696
13VRK21.88363150
14NUAK11.80680931
15SRPK11.74804274
16CDC71.71569522
17GRK11.70709819
18LIMK11.69328094
19MKNK21.68044941
20CAMKK21.65724113
21FGFR21.58559138
22PLK31.42435306
23TLK11.38572294
24BUB11.26165949
25MAP3K121.22616793
26PAK31.21128903
27ACVR1B1.21114528
28VRK11.14489113
29PIK3CA1.13671055
30MAPK131.11898399
31PLK21.11889871
32NEK11.11096920
33PRKCG1.11055399
34PLK41.09773892
35MARK11.09552544
36PLK11.09035447
37TXK1.05238156
38MAP3K111.03208351
39EIF2AK11.02689623
40CAMK1D1.02296591
41OXSR11.01062807
42CASK0.96777419
43EPHB20.93574388
44TIE10.93166883
45MKNK10.89545802
46MAP2K70.88929969
47CAMK10.82553177
48PDK20.82505865
49NME20.82198573
50RPS6KA50.81976558
51MINK10.80926007
52KDR0.79437629
53CSNK1G20.79297034
54MAP3K90.79127380
55PRKCQ0.78682568
56TSSK60.77615381
57INSRR0.76911376
58CSNK1G10.72855253
59AURKA0.71969150
60MST40.68968609
61MAP4K20.68067611
62NTRK20.67770913
63TGFBR10.67219068
64CDK190.66161123
65PRKCE0.65641651
66PRKCI0.65181502
67DYRK30.64454215
68PRKCZ0.62904741
69PBK0.62538765
70PASK0.62167747
71ADRBK10.61621912
72CAMK1G0.61442642
73SGK2230.61196297
74SGK4940.61196297
75ATR0.60787423
76NME10.59649951
77TRIM280.59275625
78CSNK1G30.58625400
79PHKG20.58014832
80PHKG10.58014832
81CSNK2A20.57234335
82WNK10.56192765
83CAMK2A0.54146980
84CSNK1E0.53763687
85AURKB0.52866587
86EIF2AK30.51587313
87CAMKK10.51542797
88PRKCH0.51322242
89TAF10.51213806
90OBSCN0.49604174
91LRRK20.49519313
92TAOK30.49458082
93ROCK10.48896005
94CDK30.48751216
95CSNK2A10.48233655
96PRKACA0.47850194
97MAP3K40.44823707
98DYRK1A0.43357073
99TTK0.43091310
100RPS6KA40.41868822

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.48806098
2Oxidative phosphorylation_Homo sapiens_hsa001903.95883876
3Parkinsons disease_Homo sapiens_hsa050123.42276866
4RNA polymerase_Homo sapiens_hsa030202.62127280
5Huntingtons disease_Homo sapiens_hsa050162.49853740
6Proteasome_Homo sapiens_hsa030502.49478215
7Homologous recombination_Homo sapiens_hsa034402.30939915
8Cardiac muscle contraction_Homo sapiens_hsa042602.21257167
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18514280
10Alzheimers disease_Homo sapiens_hsa050102.16436489
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11427944
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06932197
13Protein export_Homo sapiens_hsa030602.04543428
14Mismatch repair_Homo sapiens_hsa034302.00354656
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93076211
16Basal transcription factors_Homo sapiens_hsa030221.91259004
17Fanconi anemia pathway_Homo sapiens_hsa034601.89894587
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87398815
19Phototransduction_Homo sapiens_hsa047441.72368746
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71841539
21Propanoate metabolism_Homo sapiens_hsa006401.68671314
22Linoleic acid metabolism_Homo sapiens_hsa005911.68621242
23DNA replication_Homo sapiens_hsa030301.64185948
24RNA degradation_Homo sapiens_hsa030181.54923095
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54643646
26Pyrimidine metabolism_Homo sapiens_hsa002401.43483072
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.40321036
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38758847
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38643975
30One carbon pool by folate_Homo sapiens_hsa006701.38456030
31Steroid biosynthesis_Homo sapiens_hsa001001.35431447
32Nitrogen metabolism_Homo sapiens_hsa009101.34937761
33Nicotine addiction_Homo sapiens_hsa050331.30091876
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28360772
35Nucleotide excision repair_Homo sapiens_hsa034201.28315237
36Purine metabolism_Homo sapiens_hsa002301.25243746
37Selenocompound metabolism_Homo sapiens_hsa004501.25016535
38Pyruvate metabolism_Homo sapiens_hsa006201.20493919
39Sulfur relay system_Homo sapiens_hsa041221.19503035
40Butanoate metabolism_Homo sapiens_hsa006501.19332776
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13098768
42Spliceosome_Homo sapiens_hsa030401.12482717
43Peroxisome_Homo sapiens_hsa041461.07715391
44RNA transport_Homo sapiens_hsa030131.06966178
45Ether lipid metabolism_Homo sapiens_hsa005651.06418733
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04097203
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02377352
48Base excision repair_Homo sapiens_hsa034100.99004683
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96653987
50Tryptophan metabolism_Homo sapiens_hsa003800.93423464
51Olfactory transduction_Homo sapiens_hsa047400.90294368
52Fat digestion and absorption_Homo sapiens_hsa049750.87676117
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82207099
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81767905
55Metabolic pathways_Homo sapiens_hsa011000.81274329
56Collecting duct acid secretion_Homo sapiens_hsa049660.77493050
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75315357
58Non-homologous end-joining_Homo sapiens_hsa034500.73957709
59Caffeine metabolism_Homo sapiens_hsa002320.72841801
60Sulfur metabolism_Homo sapiens_hsa009200.67237650
61Hedgehog signaling pathway_Homo sapiens_hsa043400.62623166
62Basal cell carcinoma_Homo sapiens_hsa052170.59486406
63Taste transduction_Homo sapiens_hsa047420.59234357
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59166113
65Arachidonic acid metabolism_Homo sapiens_hsa005900.58143275
66beta-Alanine metabolism_Homo sapiens_hsa004100.57730176
67Morphine addiction_Homo sapiens_hsa050320.57542588
68Glutathione metabolism_Homo sapiens_hsa004800.55954194
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54827420
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53121282
71Fatty acid elongation_Homo sapiens_hsa000620.48495066
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.48232413
73Synaptic vesicle cycle_Homo sapiens_hsa047210.46603552
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46481047
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45676760
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.44787463
77Glutamatergic synapse_Homo sapiens_hsa047240.44216228
78Folate biosynthesis_Homo sapiens_hsa007900.43765533
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43337948
80GABAergic synapse_Homo sapiens_hsa047270.41778912
81Retinol metabolism_Homo sapiens_hsa008300.40899585
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40502023
83Chemical carcinogenesis_Homo sapiens_hsa052040.39960533
84Ovarian steroidogenesis_Homo sapiens_hsa049130.38702827
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36720940
86Insulin secretion_Homo sapiens_hsa049110.34678503
87Arginine and proline metabolism_Homo sapiens_hsa003300.32934787
88Fatty acid degradation_Homo sapiens_hsa000710.32307504
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30436388
90Tyrosine metabolism_Homo sapiens_hsa003500.29240279
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25341933
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23855590
93Dorso-ventral axis formation_Homo sapiens_hsa043200.23364931
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23099040
95Oxytocin signaling pathway_Homo sapiens_hsa049210.19594150
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.16355140
97Pancreatic secretion_Homo sapiens_hsa049720.15847786
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.14759468
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14384579
100Serotonergic synapse_Homo sapiens_hsa047260.13660568

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