RPSAP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.83357269
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.17546599
3ATP synthesis coupled proton transport (GO:0015986)6.17546599
4ribosomal small subunit assembly (GO:0000028)5.77009481
5maturation of SSU-rRNA (GO:0030490)5.57666623
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.52620393
7viral transcription (GO:0019083)5.30876943
8protein neddylation (GO:0045116)5.18967981
9translational termination (GO:0006415)5.16192760
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.08770496
11cullin deneddylation (GO:0010388)5.06012047
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.95700961
13cotranslational protein targeting to membrane (GO:0006613)4.90683389
14protein complex biogenesis (GO:0070271)4.89669009
15protein targeting to ER (GO:0045047)4.82258513
16protein deneddylation (GO:0000338)4.80601255
17respiratory electron transport chain (GO:0022904)4.79853724
18chaperone-mediated protein transport (GO:0072321)4.78251729
19ribosomal small subunit biogenesis (GO:0042274)4.74155565
20electron transport chain (GO:0022900)4.70725721
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.60197002
22mitochondrial respiratory chain complex assembly (GO:0033108)4.59638793
23translational elongation (GO:0006414)4.57685947
24protein localization to endoplasmic reticulum (GO:0070972)4.48079830
25positive regulation of mitochondrial fission (GO:0090141)4.40540865
26DNA damage response, detection of DNA damage (GO:0042769)4.40437708
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34832122
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.34832122
29NADH dehydrogenase complex assembly (GO:0010257)4.34832122
30cellular protein complex disassembly (GO:0043624)4.12946932
31hydrogen ion transmembrane transport (GO:1902600)3.98262528
32regulation of mitochondrial translation (GO:0070129)3.96178196
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92625395
34viral life cycle (GO:0019058)3.92189035
35establishment of protein localization to mitochondrion (GO:0072655)3.91535155
36protein targeting to mitochondrion (GO:0006626)3.90818967
37water-soluble vitamin biosynthetic process (GO:0042364)3.89214884
38respiratory chain complex IV assembly (GO:0008535)3.88680914
39translational initiation (GO:0006413)3.85408465
40protein localization to mitochondrion (GO:0070585)3.80893728
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.78762664
42termination of RNA polymerase III transcription (GO:0006386)3.78762664
43translation (GO:0006412)3.73918632
44ATP biosynthetic process (GO:0006754)3.66425752
45negative regulation of response to food (GO:0032096)3.62658944
46negative regulation of appetite (GO:0032099)3.62658944
47proteasome assembly (GO:0043248)3.57462883
48proton transport (GO:0015992)3.55398204
49hydrogen transport (GO:0006818)3.50354484
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49377806
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49377806
52ribosomal large subunit biogenesis (GO:0042273)3.48305772
53oxidative phosphorylation (GO:0006119)3.44359230
54protein complex disassembly (GO:0043241)3.42461144
55pyrimidine nucleobase catabolic process (GO:0006208)3.41372110
56inner mitochondrial membrane organization (GO:0007007)3.37208192
57macromolecular complex disassembly (GO:0032984)3.35837151
58regulation of mitochondrial fission (GO:0090140)3.35309266
59protein targeting to membrane (GO:0006612)3.33860388
60pseudouridine synthesis (GO:0001522)3.28505225
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28341202
62cytochrome complex assembly (GO:0017004)3.28325094
63aerobic respiration (GO:0009060)3.26926526
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20469939
65intracellular protein transmembrane import (GO:0044743)3.15275051
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12408595
67somite development (GO:0061053)3.11803617
68mitochondrial transport (GO:0006839)3.10892875
69platelet dense granule organization (GO:0060155)3.09753610
70nonmotile primary cilium assembly (GO:0035058)3.08386643
71cellular component biogenesis (GO:0044085)3.05859398
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.04412028
73protein-cofactor linkage (GO:0018065)3.03011916
74regulation of cellular amino acid metabolic process (GO:0006521)3.01360284
75spliceosomal snRNP assembly (GO:0000387)2.98475617
76organelle disassembly (GO:1903008)2.97972304
77sequestering of actin monomers (GO:0042989)2.96433556
787-methylguanosine mRNA capping (GO:0006370)2.92774022
79peptidyl-histidine modification (GO:0018202)2.90485354
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90458374
81RNA capping (GO:0036260)2.87999690
827-methylguanosine RNA capping (GO:0009452)2.87999690
83spliceosomal complex assembly (GO:0000245)2.85939647
84mRNA catabolic process (GO:0006402)2.85915684
85lateral sprouting from an epithelium (GO:0060601)2.85726867
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83215986
87ribonucleoside triphosphate biosynthetic process (GO:0009201)2.83033887
88nucleotide transmembrane transport (GO:1901679)2.82218533
89energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81586557
90ATP hydrolysis coupled proton transport (GO:0015991)2.81586557
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72506553
92tRNA metabolic process (GO:0006399)2.72029546
93histone mRNA metabolic process (GO:0008334)2.69897504
94gamma-aminobutyric acid transport (GO:0015812)2.69423545
95nucleobase catabolic process (GO:0046113)2.67053916
96tRNA processing (GO:0008033)2.66448167
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66341995
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66341995
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66341995
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63087700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.04045213
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86965909
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.20112403
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.91959451
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26486774
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19880873
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16823530
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07368542
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91869846
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90798852
11ELK1_19687146_ChIP-ChIP_HELA_Human2.90688447
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.83835159
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.79481439
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44276418
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43272050
16VDR_22108803_ChIP-Seq_LS180_Human2.40147125
17VDR_23849224_ChIP-Seq_CD4+_Human2.33212637
18IGF1R_20145208_ChIP-Seq_DFB_Human2.29628525
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13782881
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13532286
21MYC_18940864_ChIP-ChIP_HL60_Human2.03358219
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90858377
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88184747
24DCP1A_22483619_ChIP-Seq_HELA_Human1.85029273
25EWS_26573619_Chip-Seq_HEK293_Human1.84291302
26FUS_26573619_Chip-Seq_HEK293_Human1.83636228
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83232649
28FOXP3_21729870_ChIP-Seq_TREG_Human1.83228675
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81154073
30XRN2_22483619_ChIP-Seq_HELA_Human1.78855067
31ZNF274_21170338_ChIP-Seq_K562_Hela1.75446186
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.73687029
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71562145
34TTF2_22483619_ChIP-Seq_HELA_Human1.70780355
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60012719
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58773919
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54711978
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53446066
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51479159
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50709303
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50110493
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49522604
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46649789
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44592208
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.42958120
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40674933
47TP53_22573176_ChIP-Seq_HFKS_Human1.40526179
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.33485499
49TAF15_26573619_Chip-Seq_HEK293_Human1.32887240
50P300_19829295_ChIP-Seq_ESCs_Human1.32313038
51GABP_19822575_ChIP-Seq_HepG2_Human1.31253653
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28117509
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26159298
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25584644
55GBX2_23144817_ChIP-Seq_PC3_Human1.25116466
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24503745
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21907481
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20477914
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14844446
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14548712
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14044198
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13329330
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08505242
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.07805670
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05525936
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.03905287
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02977185
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00151477
69EZH2_22144423_ChIP-Seq_EOC_Human0.99687537
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96231424
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95676002
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92661412
73RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91597750
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90806264
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.90481242
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.89445040
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88404660
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88261441
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87791756
80RNF2_27304074_Chip-Seq_NSC_Mouse0.87299179
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85916663
82ERG_20517297_ChIP-Seq_VCAP_Human0.84426344
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83617714
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82909370
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82694886
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.82306760
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82093453
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79042754
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78512685
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75352544
91AR_20517297_ChIP-Seq_VCAP_Human0.72642488
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70644238
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70373866
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.70373866
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70194937
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.67847857
97AR_25329375_ChIP-Seq_VCAP_Human0.67317696
98HTT_18923047_ChIP-ChIP_STHdh_Human0.67219235
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.66761345
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66588595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.77548577
2MP0001986_abnormal_taste_sensitivity3.30603616
3MP0001529_abnormal_vocalization3.15727500
4MP0009379_abnormal_foot_pigmentation3.00463367
5MP0002102_abnormal_ear_morphology2.96775390
6MP0002277_abnormal_respiratory_mucosa2.87056214
7MP0006292_abnormal_olfactory_placode2.72889457
8MP0003122_maternal_imprinting2.58406028
9MP0002837_dystrophic_cardiac_calcinosis2.53684530
10MP0003136_yellow_coat_color2.51263944
11MP0003880_abnormal_central_pattern2.46106972
12MP0003315_abnormal_perineum_morphology2.32442924
13MP0005423_abnormal_somatic_nervous2.26346952
14MP0005187_abnormal_penis_morphology2.21484078
15MP0008877_abnormal_DNA_methylation2.10995142
16MP0004142_abnormal_muscle_tone1.98206122
17MP0001293_anophthalmia1.96169541
18MP0002938_white_spotting1.91232136
19MP0002653_abnormal_ependyma_morphology1.89080711
20MP0003121_genomic_imprinting1.84126747
21MP0001485_abnormal_pinna_reflex1.82650887
22MP0003787_abnormal_imprinting1.79352758
23MP0000372_irregular_coat_pigmentation1.76875769
24MP0003646_muscle_fatigue1.76000761
25MP0004145_abnormal_muscle_electrophysio1.73097692
26MP0001984_abnormal_olfaction1.70451550
27MP0005377_hearing/vestibular/ear_phenot1.69547837
28MP0003878_abnormal_ear_physiology1.69547837
29MP0010030_abnormal_orbit_morphology1.68636902
30MP0003186_abnormal_redox_activity1.67664620
31MP0006072_abnormal_retinal_apoptosis1.62538566
32MP0003718_maternal_effect1.60236535
33MP0005084_abnormal_gallbladder_morpholo1.48929657
34MP0000049_abnormal_middle_ear1.46735602
35MP0006035_abnormal_mitochondrial_morpho1.46675446
36MP0005171_absent_coat_pigmentation1.45975946
37MP0002272_abnormal_nervous_system1.44179986
38MP0005248_abnormal_Harderian_gland1.43526111
39MP0006276_abnormal_autonomic_nervous1.42424460
40MP0000631_abnormal_neuroendocrine_gland1.41570952
41MP0003119_abnormal_digestive_system1.41275198
42MP0003011_delayed_dark_adaptation1.39968129
43MP0001502_abnormal_circadian_rhythm1.39378443
44MP0008789_abnormal_olfactory_epithelium1.36112610
45MP0002736_abnormal_nociception_after1.35905838
46MP0008995_early_reproductive_senescence1.35312946
47MP0009745_abnormal_behavioral_response1.32293402
48MP0000647_abnormal_sebaceous_gland1.28348114
49MP0005503_abnormal_tendon_morphology1.23069356
50MP0005253_abnormal_eye_physiology1.20873072
51MP0001486_abnormal_startle_reflex1.19743908
52MP0004859_abnormal_synaptic_plasticity1.17878355
53MP0004742_abnormal_vestibular_system1.17585861
54MP0004885_abnormal_endolymph1.13946329
55MP0001905_abnormal_dopamine_level1.11651296
56MP0005499_abnormal_olfactory_system1.10054505
57MP0005394_taste/olfaction_phenotype1.10054505
58MP0001346_abnormal_lacrimal_gland1.08021509
59MP0005645_abnormal_hypothalamus_physiol1.07437760
60MP0006036_abnormal_mitochondrial_physio1.04852007
61MP0001968_abnormal_touch/_nociception1.04397399
62MP0001299_abnormal_eye_distance/1.03661937
63MP0009046_muscle_twitch1.02794292
64MP0000026_abnormal_inner_ear1.02590997
65MP0000955_abnormal_spinal_cord1.01301734
66MP0001188_hyperpigmentation0.97042148
67MP0001286_abnormal_eye_development0.94866175
68MP0008875_abnormal_xenobiotic_pharmacok0.91354060
69MP0003567_abnormal_fetal_cardiomyocyte0.89662006
70MP0004957_abnormal_blastocyst_morpholog0.87290961
71MP0008058_abnormal_DNA_repair0.85893365
72MP0003635_abnormal_synaptic_transmissio0.84913433
73MP0002160_abnormal_reproductive_system0.81982508
74MP0005636_abnormal_mineral_homeostasis0.81869853
75MP0003938_abnormal_ear_development0.81389537
76MP0003937_abnormal_limbs/digits/tail_de0.81350716
77MP0000566_synostosis0.80188301
78MP0000778_abnormal_nervous_system0.77595173
79MP0004270_analgesia0.74854877
80MP0002067_abnormal_sensory_capabilities0.74640218
81MP0002064_seizures0.74526158
82MP0008872_abnormal_physiological_respon0.74078781
83MP0005391_vision/eye_phenotype0.73973902
84MP0001963_abnormal_hearing_physiology0.73738869
85MP0001440_abnormal_grooming_behavior0.73070357
86MP0003786_premature_aging0.72954321
87MP0002184_abnormal_innervation0.72655833
88MP0005386_behavior/neurological_phenoty0.72605881
89MP0004924_abnormal_behavior0.72605881
90MP0002572_abnormal_emotion/affect_behav0.71007733
91MP0003755_abnormal_palate_morphology0.69255900
92MP0005551_abnormal_eye_electrophysiolog0.68107647
93MP0002734_abnormal_mechanical_nocicepti0.67750550
94MP0002557_abnormal_social/conspecific_i0.67426884
95MP0005410_abnormal_fertilization0.67140038
96MP0002822_catalepsy0.66337389
97MP0002282_abnormal_trachea_morphology0.66202192
98MP0002234_abnormal_pharynx_morphology0.65970920
99MP0002095_abnormal_skin_pigmentation0.65655055
100MP0003936_abnormal_reproductive_system0.65379421

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.43085408
2Lipid accumulation in hepatocytes (HP:0006561)4.66530805
3Acute necrotizing encephalopathy (HP:0006965)4.58515499
4Mitochondrial inheritance (HP:0001427)4.30949696
5Abnormal mitochondria in muscle tissue (HP:0008316)4.18070624
6Renal Fanconi syndrome (HP:0001994)4.00524362
7Acute encephalopathy (HP:0006846)4.00006310
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.92273774
9Increased CSF lactate (HP:0002490)3.88361560
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.87116394
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.87116394
12Increased intramyocellular lipid droplets (HP:0012240)3.76211942
13Progressive macrocephaly (HP:0004481)3.63040047
14Exertional dyspnea (HP:0002875)3.49303462
15Reticulocytopenia (HP:0001896)3.49284102
16Intestinal atresia (HP:0011100)3.26235406
17Hepatocellular necrosis (HP:0001404)3.15926828
18Abnormality of the corticospinal tract (HP:0002492)3.10668895
19Medial flaring of the eyebrow (HP:0010747)3.08661327
20Respiratory difficulties (HP:0002880)3.02139390
21Septo-optic dysplasia (HP:0100842)2.99898108
22Gait imbalance (HP:0002141)2.97671518
23Increased muscle lipid content (HP:0009058)2.91629859
24Hepatic necrosis (HP:0002605)2.88168359
25Cerebral edema (HP:0002181)2.87226540
26Congenital primary aphakia (HP:0007707)2.78452489
27Nephrogenic diabetes insipidus (HP:0009806)2.70631804
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70145184
29Increased serum lactate (HP:0002151)2.67985616
30Pancreatic cysts (HP:0001737)2.63904673
31Exercise intolerance (HP:0003546)2.59404810
32Esophageal atresia (HP:0002032)2.56342369
33Optic nerve coloboma (HP:0000588)2.56001972
34True hermaphroditism (HP:0010459)2.55838255
35Colon cancer (HP:0003003)2.53302480
36Lactic acidosis (HP:0003128)2.51042970
37Hyperglycinemia (HP:0002154)2.44817912
38Nephronophthisis (HP:0000090)2.44198157
39Anophthalmia (HP:0000528)2.43207370
40Bilateral microphthalmos (HP:0007633)2.41172262
41Molar tooth sign on MRI (HP:0002419)2.40893127
42Abnormality of midbrain morphology (HP:0002418)2.40893127
43Hypothermia (HP:0002045)2.39115719
44Abnormality of cells of the erythroid lineage (HP:0012130)2.38179974
45Methylmalonic acidemia (HP:0002912)2.37714196
46Oligodactyly (hands) (HP:0001180)2.37410131
47Macrocytic anemia (HP:0001972)2.35692622
48Large for gestational age (HP:0001520)2.35393531
49Aplastic anemia (HP:0001915)2.33615464
50Urinary urgency (HP:0000012)2.32978603
51Optic nerve hypoplasia (HP:0000609)2.32137141
52Absent septum pellucidum (HP:0001331)2.30867057
53Abnormal number of erythroid precursors (HP:0012131)2.30112388
54Vaginal atresia (HP:0000148)2.29823134
55Pancreatic fibrosis (HP:0100732)2.28348772
56Optic disc pallor (HP:0000543)2.27685167
57Occipital encephalocele (HP:0002085)2.25246646
58Abnormality of renal resorption (HP:0011038)2.25002102
59Hyperphosphaturia (HP:0003109)2.23941017
60Rimmed vacuoles (HP:0003805)2.19499756
61Shoulder girdle muscle weakness (HP:0003547)2.18823777
62Abnormality of the pons (HP:0007361)2.18772174
63Genital tract atresia (HP:0001827)2.14693545
64Abnormality of alanine metabolism (HP:0010916)2.13736003
65Hyperalaninemia (HP:0003348)2.13736003
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13736003
67Abnormality of urine glucose concentration (HP:0011016)2.12805159
68Glycosuria (HP:0003076)2.12805159
69Hemivertebrae (HP:0002937)2.12029651
70Type II lissencephaly (HP:0007260)2.07559319
71Gastrointestinal atresia (HP:0002589)2.06529702
72Focal motor seizures (HP:0011153)2.04392046
73Microvesicular hepatic steatosis (HP:0001414)2.04003893
74Respiratory failure (HP:0002878)2.03985427
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03667157
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03667157
77Abnormality of the renal medulla (HP:0100957)2.01700066
78Sclerocornea (HP:0000647)2.00725922
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99323501
80Rib fusion (HP:0000902)1.98131462
81Leukodystrophy (HP:0002415)1.95020192
82Cupped ear (HP:0000378)1.93472944
83Hypoplasia of the pons (HP:0012110)1.92997965
84Methylmalonic aciduria (HP:0012120)1.92372457
85Increased serum pyruvate (HP:0003542)1.90937573
86Double outlet right ventricle (HP:0001719)1.90504210
87Congenital malformation of the right heart (HP:0011723)1.90504210
88Poor coordination (HP:0002370)1.89711961
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.89681057
90Bile duct proliferation (HP:0001408)1.88472333
91Abnormal biliary tract physiology (HP:0012439)1.88472333
92Pelvic girdle muscle weakness (HP:0003749)1.87913048
93Lethargy (HP:0001254)1.84651351
94Unsteady gait (HP:0002317)1.84612578
95Poor suck (HP:0002033)1.84124522
96Anencephaly (HP:0002323)1.84123641
97Morphological abnormality of the pyramidal tract (HP:0002062)1.83586376
98Abnormality of the musculature of the pelvis (HP:0001469)1.83154745
99Abnormality of the hip-girdle musculature (HP:0001445)1.83154745
100Abnormality of the septum pellucidum (HP:0007375)1.82992582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.68490874
2VRK23.76986214
3BCR3.44051270
4TNIK2.92440939
5TLK12.82630689
6ZAK2.75227546
7SIK32.68411894
8MAP4K22.48288160
9TSSK62.31104938
10WNK32.27947781
11MUSK2.22236894
12EPHA32.19047784
13VRK12.16180112
14MAP3K42.16113548
15TAF12.07038176
16MAP2K72.04278696
17DYRK21.89509163
18BUB11.85463415
19SRPK11.84937553
20PBK1.70900631
21MARK11.62260935
22CASK1.60473669
23MST41.53956222
24ERBB31.46530666
25EIF2AK11.42193601
26CDK81.40389565
27BCKDK1.31965802
28CSNK1G21.31692286
29OBSCN1.30032286
30WNK41.29929163
31RPS6KA41.25527124
32PINK11.18034317
33STK38L1.14131584
34GRK71.12658836
35CSNK1G31.11140140
36PASK1.09267265
37STK161.08548077
38ADRBK21.04509478
39PNCK0.98145877
40PHKG10.97871936
41PHKG20.97871936
42CSNK1G10.96401601
43CSNK1A1L0.92912021
44NME10.91931001
45NME20.91780376
46PLK30.91638177
47TXK0.91447631
48MKNK10.85408502
49LIMK10.84266370
50MAPK130.83197424
51NUAK10.81902301
52PIK3CG0.77107455
53PRKCG0.76893116
54CDC70.75358656
55BMPR1B0.75264708
56PLK20.73103224
57GRK10.70632737
58MKNK20.70404424
59DYRK30.67652739
60ACVR1B0.65719391
61PLK40.65719025
62MAP2K40.60626265
63EIF2AK30.57114541
64NTRK20.56908765
65ADRBK10.52693203
66PRKCE0.50955299
67CSNK2A20.50549392
68RPS6KA50.50108399
69MAPKAPK50.47768937
70PLK10.47428020
71ABL20.46995747
72TNK20.44426264
73MINK10.44132559
74CDK190.42112292
75CSNK2A10.41899270
76TGFBR10.41603228
77EPHB20.41548970
78INSRR0.41475606
79STK390.41402987
80CDK30.41252814
81ALK0.41238133
82TAOK30.40720361
83CSNK1A10.38832515
84CAMK2A0.38786946
85PAK30.38092378
86AURKA0.36386297
87FGFR10.35570966
88IKBKB0.34580815
89NEK10.34515335
90CHEK20.30974859
91PRKACA0.30356527
92AKT20.30257979
93DAPK30.30036352
94GRK50.26159788
95PRKACB0.25765854
96TESK10.24562388
97CSNK1E0.24087926
98LATS10.23201144
99PRKG10.22590948
100PAK60.20621074

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.91044735
2Ribosome_Homo sapiens_hsa030104.88723712
3Parkinsons disease_Homo sapiens_hsa050124.10136358
4Proteasome_Homo sapiens_hsa030503.77119196
5Protein export_Homo sapiens_hsa030603.29914250
6RNA polymerase_Homo sapiens_hsa030203.06460170
7Huntingtons disease_Homo sapiens_hsa050162.86687427
8Alzheimers disease_Homo sapiens_hsa050102.77130226
9Cardiac muscle contraction_Homo sapiens_hsa042602.58124777
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32874291
11Nicotine addiction_Homo sapiens_hsa050332.31405855
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04285559
13Basal transcription factors_Homo sapiens_hsa030221.99016887
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98530041
15Mismatch repair_Homo sapiens_hsa034301.98454249
16Spliceosome_Homo sapiens_hsa030401.80750027
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78582118
18Collecting duct acid secretion_Homo sapiens_hsa049661.52053634
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44055903
20One carbon pool by folate_Homo sapiens_hsa006701.39569157
21RNA transport_Homo sapiens_hsa030131.38582332
22RNA degradation_Homo sapiens_hsa030181.33653026
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33373944
24Phototransduction_Homo sapiens_hsa047441.32536895
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29277701
26Nitrogen metabolism_Homo sapiens_hsa009101.19346915
27Homologous recombination_Homo sapiens_hsa034401.19104063
28GABAergic synapse_Homo sapiens_hsa047271.18103176
29Nucleotide excision repair_Homo sapiens_hsa034201.10437237
30Basal cell carcinoma_Homo sapiens_hsa052171.07287097
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06322708
32Sulfur relay system_Homo sapiens_hsa041221.02716196
33Propanoate metabolism_Homo sapiens_hsa006401.01721132
34Pyrimidine metabolism_Homo sapiens_hsa002400.97182103
35Steroid biosynthesis_Homo sapiens_hsa001000.95225644
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94071971
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93133782
38Vibrio cholerae infection_Homo sapiens_hsa051100.92904406
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89337962
40Regulation of autophagy_Homo sapiens_hsa041400.88359066
41Fanconi anemia pathway_Homo sapiens_hsa034600.86798644
42DNA replication_Homo sapiens_hsa030300.85623757
43Taste transduction_Homo sapiens_hsa047420.83514009
44Butanoate metabolism_Homo sapiens_hsa006500.79410986
45Purine metabolism_Homo sapiens_hsa002300.79219917
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77989797
47Peroxisome_Homo sapiens_hsa041460.76967499
48Metabolic pathways_Homo sapiens_hsa011000.73683160
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72792960
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72660634
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71879215
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69059805
53Pyruvate metabolism_Homo sapiens_hsa006200.68938718
54Morphine addiction_Homo sapiens_hsa050320.68136633
55Synaptic vesicle cycle_Homo sapiens_hsa047210.66584982
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.65664362
57Fatty acid elongation_Homo sapiens_hsa000620.63183876
58Hedgehog signaling pathway_Homo sapiens_hsa043400.58823472
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58131350
60Selenocompound metabolism_Homo sapiens_hsa004500.53919284
61Arginine biosynthesis_Homo sapiens_hsa002200.52957915
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52026279
63Sulfur metabolism_Homo sapiens_hsa009200.50548081
64Base excision repair_Homo sapiens_hsa034100.50007283
65Linoleic acid metabolism_Homo sapiens_hsa005910.48075546
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46653019
67Mineral absorption_Homo sapiens_hsa049780.45701905
68beta-Alanine metabolism_Homo sapiens_hsa004100.45596078
69Vitamin B6 metabolism_Homo sapiens_hsa007500.44743251
70mRNA surveillance pathway_Homo sapiens_hsa030150.41872525
71Tyrosine metabolism_Homo sapiens_hsa003500.40676732
72Wnt signaling pathway_Homo sapiens_hsa043100.39333748
73Asthma_Homo sapiens_hsa053100.37214992
74Biosynthesis of amino acids_Homo sapiens_hsa012300.36606744
75Rheumatoid arthritis_Homo sapiens_hsa053230.34767053
76Olfactory transduction_Homo sapiens_hsa047400.34540176
77Carbon metabolism_Homo sapiens_hsa012000.32014067
78Folate biosynthesis_Homo sapiens_hsa007900.31584971
79Insulin secretion_Homo sapiens_hsa049110.31574796
80Phenylalanine metabolism_Homo sapiens_hsa003600.31364643
81Glutathione metabolism_Homo sapiens_hsa004800.30847521
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29806656
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.29783631
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27862361
85Non-homologous end-joining_Homo sapiens_hsa034500.27789159
86Serotonergic synapse_Homo sapiens_hsa047260.25304719
87Glutamatergic synapse_Homo sapiens_hsa047240.25125873
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21874532
89Circadian rhythm_Homo sapiens_hsa047100.21643956
90Tryptophan metabolism_Homo sapiens_hsa003800.21274592
91Circadian entrainment_Homo sapiens_hsa047130.20973878
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19674423
93Dopaminergic synapse_Homo sapiens_hsa047280.19195410
94Ether lipid metabolism_Homo sapiens_hsa005650.18928479
95Autoimmune thyroid disease_Homo sapiens_hsa053200.17347458
96Arginine and proline metabolism_Homo sapiens_hsa003300.16947640
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16329910
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15946470
99Epstein-Barr virus infection_Homo sapiens_hsa051690.15618533
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15011594

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