RPSAP45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)8.24449020
2water-soluble vitamin biosynthetic process (GO:0042364)7.04328801
3protein complex biogenesis (GO:0070271)6.16367160
4ribosomal small subunit assembly (GO:0000028)5.60428131
5mitochondrial respiratory chain complex assembly (GO:0033108)5.56746964
6base-excision repair, AP site formation (GO:0006285)5.41438234
7regulation of mitochondrial translation (GO:0070129)5.39528769
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.29365737
9chaperone-mediated protein transport (GO:0072321)5.21482999
10negative regulation of membrane potential (GO:0045837)4.89653862
11positive regulation of interleukin-17 production (GO:0032740)4.77372822
12cytochrome complex assembly (GO:0017004)4.68996095
13DNA deamination (GO:0045006)4.66128037
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.61412898
15NADH dehydrogenase complex assembly (GO:0010257)4.61412898
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61412898
17pseudouridine synthesis (GO:0001522)4.54421022
18pyrimidine nucleotide catabolic process (GO:0006244)4.39760837
19proteasome assembly (GO:0043248)4.23378011
20cytidine metabolic process (GO:0046087)4.07869954
21cytidine catabolic process (GO:0006216)4.07869954
22cytidine deamination (GO:0009972)4.07869954
23protein deneddylation (GO:0000338)4.03434896
24behavioral response to nicotine (GO:0035095)3.95269163
25protein neddylation (GO:0045116)3.82684941
26ncRNA 3-end processing (GO:0043628)3.77901137
27vitamin biosynthetic process (GO:0009110)3.74766018
28maturation of 5.8S rRNA (GO:0000460)3.70774214
29deoxyribonucleotide catabolic process (GO:0009264)3.69588901
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66838035
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65455175
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.63862996
33histone deubiquitination (GO:0016578)3.60903788
34rRNA modification (GO:0000154)3.55754919
35positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.55087913
36deoxyribose phosphate catabolic process (GO:0046386)3.51323231
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46361128
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46328554
39protein import into peroxisome matrix (GO:0016558)3.45758007
40regulation of isotype switching to IgG isotypes (GO:0048302)3.44855765
41pyrimidine ribonucleoside catabolic process (GO:0046133)3.39375122
42positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.26025153
43cellular component biogenesis (GO:0044085)3.23360812
44cobalamin metabolic process (GO:0009235)3.22125881
45termination of RNA polymerase III transcription (GO:0006386)3.18348077
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.18348077
47rRNA methylation (GO:0031167)3.16939133
48intracellular protein transmembrane import (GO:0044743)3.16581223
49transcription from mitochondrial promoter (GO:0006390)3.14991751
50adaptation of signaling pathway (GO:0023058)3.13150669
51platelet dense granule organization (GO:0060155)3.12656556
52regulation of regulatory T cell differentiation (GO:0045589)3.12471374
53autophagic vacuole fusion (GO:0000046)3.11674821
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08881246
55positive regulation of DNA recombination (GO:0045911)3.06214246
56protein K48-linked deubiquitination (GO:0071108)3.05998038
57regulation of cellular amino acid metabolic process (GO:0006521)3.03446381
58regulation of immunoglobulin secretion (GO:0051023)3.02049925
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02013964
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.98833939
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98609117
62cell wall macromolecule metabolic process (GO:0044036)2.98535966
63positive regulation of chemokine biosynthetic process (GO:0045080)2.98218626
64ribosomal large subunit biogenesis (GO:0042273)2.98196508
65response to nitric oxide (GO:0071731)2.96124602
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95616782
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89064186
68negative regulation of glycogen biosynthetic process (GO:0045719)2.88560351
69regulation of interleukin-17 production (GO:0032660)2.84448875
70positive regulation of endothelial cell differentiation (GO:0045603)2.83173928
71mitochondrial RNA metabolic process (GO:0000959)2.82995758
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82565676
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82565676
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82565676
75cytokine biosynthetic process (GO:0042089)2.80919227
76positive regulation of ligase activity (GO:0051351)2.80130095
77iron-sulfur cluster assembly (GO:0016226)2.80065731
78metallo-sulfur cluster assembly (GO:0031163)2.80065731
79T cell migration (GO:0072678)2.79763211
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79363474
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79363474
82cellular response to interleukin-15 (GO:0071350)2.79256968
83regulation of chemokine biosynthetic process (GO:0045073)2.79157483
84positive regulation of isotype switching (GO:0045830)2.78817076
85forebrain morphogenesis (GO:0048853)2.78557744
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.76984240
87misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.74109959
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72969737
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72646901
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69971792
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.69971792
92ATP synthesis coupled proton transport (GO:0015986)2.69735324
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69735324
94GTP biosynthetic process (GO:0006183)2.69066209
95rRNA processing (GO:0006364)2.69041201
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68627250
97negative regulation of ligase activity (GO:0051352)2.68627250
98viral transcription (GO:0019083)2.67779665
99protein localization to endoplasmic reticulum (GO:0070972)2.65588091
100regulation of podosome assembly (GO:0071801)2.64855704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.35759170
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02117328
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.91325182
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.89445567
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.74530777
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.71776986
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27032572
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22738625
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.16880156
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93655228
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.86001041
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.81239431
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77619160
14FOXP3_21729870_ChIP-Seq_TREG_Human2.55960040
15VDR_23849224_ChIP-Seq_CD4+_Human2.49085417
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.47017320
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45833471
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23220382
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.21428037
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19592643
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17859734
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12078076
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.09798350
24CIITA_25753668_ChIP-Seq_RAJI_Human2.08174509
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.96139719
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91066353
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86196704
28TTF2_22483619_ChIP-Seq_HELA_Human1.84279865
29GABP_19822575_ChIP-Seq_HepG2_Human1.83423912
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80384618
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.78711478
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66506997
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62301380
34DCP1A_22483619_ChIP-Seq_HELA_Human1.57675830
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55312501
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54328356
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52661390
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50913891
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50657518
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.48134130
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46497105
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43599842
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.43192424
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39525331
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37524126
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35944282
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35389530
48ELK1_19687146_ChIP-ChIP_HELA_Human1.33238116
49NCOR_22424771_ChIP-Seq_293T_Human1.31545256
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30176841
51TAF2_19829295_ChIP-Seq_ESCs_Human1.28347773
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27209224
53MYC_18940864_ChIP-ChIP_HL60_Human1.27128640
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.25342308
55GATA3_26560356_Chip-Seq_TH2_Human1.25147048
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24500732
57NANOG_20526341_ChIP-Seq_ESCs_Human1.22795229
58ZNF274_21170338_ChIP-Seq_K562_Hela1.22570263
59XRN2_22483619_ChIP-Seq_HELA_Human1.21995935
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21259925
61BCL6_27268052_Chip-Seq_Bcells_Human1.19884419
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15473609
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14466714
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13813178
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13477157
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11363099
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11170571
68MYB_26560356_Chip-Seq_TH2_Human1.10667972
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09313045
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.09313045
71P53_21459846_ChIP-Seq_SAOS-2_Human1.08335675
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07678942
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07017588
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.06704082
75TP53_22573176_ChIP-Seq_HFKS_Human1.06536217
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05023180
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03615473
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.01078046
79NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99324130
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99116212
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98633854
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97980069
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97488638
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97421444
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96415235
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95531189
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93697191
88SOX2_21211035_ChIP-Seq_LN229_Human0.93031907
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92855627
90ERA_21632823_ChIP-Seq_H3396_Human0.92184026
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89093835
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88338308
93MYC_19829295_ChIP-Seq_ESCs_Human0.87622551
94GATA3_27048872_Chip-Seq_THYMUS_Human0.87009595
95P68_20966046_ChIP-Seq_HELA_Human0.86583538
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86320264
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86064647
98VDR_22108803_ChIP-Seq_LS180_Human0.84515298
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84450645
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83970738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.24808604
2MP0002837_dystrophic_cardiac_calcinosis5.16336740
3MP0003122_maternal_imprinting3.29000993
4MP0002736_abnormal_nociception_after3.28672376
5MP0001835_abnormal_antigen_presentation3.18219364
6MP0005671_abnormal_response_to2.72105385
7MP0001853_heart_inflammation2.71211806
8MP0001873_stomach_inflammation2.58314799
9MP0003123_paternal_imprinting2.51748749
10MP0001968_abnormal_touch/_nociception2.39779300
11MP0009333_abnormal_splenocyte_physiolog2.12088529
12MP0004185_abnormal_adipocyte_glucose2.11705096
13MP0003121_genomic_imprinting2.03961889
14MP0001905_abnormal_dopamine_level1.96232582
15MP0005670_abnormal_white_adipose1.90336443
16MP0009785_altered_susceptibility_to1.86426199
17MP0004742_abnormal_vestibular_system1.85991818
18MP0002148_abnormal_hypersensitivity_rea1.78836784
19MP0005084_abnormal_gallbladder_morpholo1.75959352
20MP0002277_abnormal_respiratory_mucosa1.75566583
21MP0009379_abnormal_foot_pigmentation1.75446157
22MP0008775_abnormal_heart_ventricle1.72259263
23MP0002138_abnormal_hepatobiliary_system1.64718806
24MP0002166_altered_tumor_susceptibility1.63932664
25MP0008789_abnormal_olfactory_epithelium1.63141662
26MP0008872_abnormal_physiological_respon1.58683133
27MP0003567_abnormal_fetal_cardiomyocyte1.53301240
28MP0001188_hyperpigmentation1.52569383
29MP0002102_abnormal_ear_morphology1.52350593
30MP0004133_heterotaxia1.48234692
31MP0001529_abnormal_vocalization1.47234845
32MP0002876_abnormal_thyroid_physiology1.34812227
33MP0003786_premature_aging1.33365198
34MP0006292_abnormal_olfactory_placode1.31045902
35MP0004145_abnormal_muscle_electrophysio1.28975400
36MP0003011_delayed_dark_adaptation1.28891863
37MP0000681_abnormal_thyroid_gland1.26755645
38MP0003878_abnormal_ear_physiology1.24687832
39MP0005377_hearing/vestibular/ear_phenot1.24687832
40MP0000678_abnormal_parathyroid_gland1.24158849
41MP0010155_abnormal_intestine_physiology1.23004041
42MP0003890_abnormal_embryonic-extraembry1.22413817
43MP0001661_extended_life_span1.20946331
44MP0008875_abnormal_xenobiotic_pharmacok1.17743023
45MP0001984_abnormal_olfaction1.16743514
46MP0005000_abnormal_immune_tolerance1.16228142
47MP0003866_abnormal_defecation1.13208386
48MP0002006_tumorigenesis1.13025332
49MP0005387_immune_system_phenotype1.12024146
50MP0001790_abnormal_immune_system1.12024146
51MP0003763_abnormal_thymus_physiology1.09377040
52MP0002693_abnormal_pancreas_physiology1.06966907
53MP0001800_abnormal_humoral_immune1.06308110
54MP0002928_abnormal_bile_duct1.05922571
55MP0008058_abnormal_DNA_repair1.04714754
56MP0005332_abnormal_amino_acid1.03983198
57MP0009384_cardiac_valve_regurgitation1.01365972
58MP0000343_altered_response_to0.99553112
59MP0009764_decreased_sensitivity_to0.94494322
60MP0008877_abnormal_DNA_methylation0.92096365
61MP0005083_abnormal_biliary_tract0.91663140
62MP0005389_reproductive_system_phenotype0.91303503
63MP0000537_abnormal_urethra_morphology0.90488170
64MP0000538_abnormal_urinary_bladder0.90071502
65MP0005025_abnormal_response_to0.89257676
66MP0003806_abnormal_nucleotide_metabolis0.87757703
67MP0004782_abnormal_surfactant_physiolog0.87628232
68MP0001764_abnormal_homeostasis0.86899047
69MP0005666_abnormal_adipose_tissue0.86068456
70MP0005365_abnormal_bile_salt0.85925731
71MP0002938_white_spotting0.85119039
72MP0002132_abnormal_respiratory_system0.85043988
73MP0002160_abnormal_reproductive_system0.83963205
74MP0002735_abnormal_chemical_nociception0.82393808
75MP0006036_abnormal_mitochondrial_physio0.78832255
76MP0003252_abnormal_bile_duct0.78088008
77MP0004130_abnormal_muscle_cell0.76607804
78MP0006082_CNS_inflammation0.74978664
79MP0005645_abnormal_hypothalamus_physiol0.74497634
80MP0000230_abnormal_systemic_arterial0.73717656
81MP0000049_abnormal_middle_ear0.73712335
82MP0001919_abnormal_reproductive_system0.73697651
83MP0004147_increased_porphyrin_level0.73159120
84MP0005551_abnormal_eye_electrophysiolog0.72834668
85MP0002420_abnormal_adaptive_immunity0.72056584
86MP0004924_abnormal_behavior0.71987095
87MP0005386_behavior/neurological_phenoty0.71987095
88MP0001727_abnormal_embryo_implantation0.71911777
89MP0002723_abnormal_immune_serum0.70909693
90MP0005408_hypopigmentation0.70085688
91MP0001819_abnormal_immune_cell0.69754996
92MP0002933_joint_inflammation0.69424695
93MP0001270_distended_abdomen0.67140193
94MP0009765_abnormal_xenobiotic_induced0.64879432
95MP0003448_altered_tumor_morphology0.64843756
96MP0001666_abnormal_nutrient_absorption0.64672622
97MP0005166_decreased_susceptibility_to0.64331566
98MP0005360_urolithiasis0.64201186
99MP0001756_abnormal_urination0.64139436
100MP0010329_abnormal_lipoprotein_level0.64115880

Predicted human phenotypes

RankGene SetZ-score
1Meningioma (HP:0002858)5.84400487
2Methylmalonic aciduria (HP:0012120)5.19769744
3Hyperglycinemia (HP:0002154)4.98436032
4Methylmalonic acidemia (HP:0002912)4.68110619
5Aplastic anemia (HP:0001915)4.07073989
6Increased intramyocellular lipid droplets (HP:0012240)3.57848019
7Abnormality of dicarboxylic acid metabolism (HP:0010995)3.54657423
8Dicarboxylic aciduria (HP:0003215)3.54657423
9Progressive macrocephaly (HP:0004481)3.41809139
10Acute necrotizing encephalopathy (HP:0006965)3.35777346
11Melanoma (HP:0002861)3.34764366
12Mitochondrial inheritance (HP:0001427)3.33547315
13Abnormal mitochondria in muscle tissue (HP:0008316)3.29831464
14Elevated erythrocyte sedimentation rate (HP:0003565)3.20645862
15Pancytopenia (HP:0001876)3.18235514
16Abnormality of the vitamin B12 metabolism (HP:0004341)3.11240380
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10425813
18Increased muscle lipid content (HP:0009058)3.06995264
19Increased CSF lactate (HP:0002490)3.02469729
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01745118
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01745118
22Renal Fanconi syndrome (HP:0001994)2.99162808
23Neoplasm of the lung (HP:0100526)2.98169148
24Stomatitis (HP:0010280)2.96125035
25Increased hepatocellular lipid droplets (HP:0006565)2.95564083
26Abnormality of vitamin B metabolism (HP:0004340)2.92902280
27Acute encephalopathy (HP:0006846)2.88688639
28Abnormality of glycine metabolism (HP:0010895)2.86171664
29Abnormality of serine family amino acid metabolism (HP:0010894)2.86171664
30Neoplasm of the respiratory system (HP:0100606)2.83446161
31Hepatocellular necrosis (HP:0001404)2.73992844
32Increased IgM level (HP:0003496)2.73122949
33Lipid accumulation in hepatocytes (HP:0006561)2.68999177
34Confusion (HP:0001289)2.67462197
35Ketosis (HP:0001946)2.67269089
36Increased serum lactate (HP:0002151)2.64784589
37Benign neoplasm of the central nervous system (HP:0100835)2.63770304
38Hepatic necrosis (HP:0002605)2.63755191
39Hyperammonemia (HP:0001987)2.61985639
40Lethargy (HP:0001254)2.54632798
41Hypoplasia of the uterus (HP:0000013)2.49757937
42Lymphangioma (HP:0100764)2.48349699
43Lactic acidosis (HP:0003128)2.46449790
44Abnormality of serum amino acid levels (HP:0003112)2.44473903
45Type I transferrin isoform profile (HP:0003642)2.39952715
46Multiple enchondromatosis (HP:0005701)2.38088977
47Cerebral edema (HP:0002181)2.37805379
48Abnormality of urine glucose concentration (HP:0011016)2.35157879
49Glycosuria (HP:0003076)2.35157879
503-Methylglutaconic aciduria (HP:0003535)2.29505769
51Optic disc pallor (HP:0000543)2.25581147
52IgG deficiency (HP:0004315)2.25570884
53Reduced antithrombin III activity (HP:0001976)2.21039275
54Hypoproteinemia (HP:0003075)2.19539024
55Carpal bone hypoplasia (HP:0001498)2.18912528
56Metabolic acidosis (HP:0001942)2.18204053
57Generalized aminoaciduria (HP:0002909)2.15986703
58Abnormality of T cell number (HP:0011839)2.12676102
59T lymphocytopenia (HP:0005403)2.11991901
60Spastic paraparesis (HP:0002313)2.09668000
61Thyroiditis (HP:0100646)2.09406019
62Neoplasm of the adrenal gland (HP:0100631)2.09219432
63Respiratory distress (HP:0002098)2.09038953
64Abnormal rod and cone electroretinograms (HP:0008323)2.08717553
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07371031
66Conjunctival hamartoma (HP:0100780)2.06232302
67Agammaglobulinemia (HP:0004432)2.05270555
68Aplasia/hypoplasia of the uterus (HP:0008684)2.03309697
69Respiratory failure (HP:0002878)2.01830930
70Oral leukoplakia (HP:0002745)2.00955295
71Exertional dyspnea (HP:0002875)2.00025036
72Cutaneous melanoma (HP:0012056)12.1353014
73Abnormality of alanine metabolism (HP:0010916)1.99946127
74Hyperalaninemia (HP:0003348)1.99946127
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99946127
76Congenital, generalized hypertrichosis (HP:0004540)1.99466123
77Attenuation of retinal blood vessels (HP:0007843)1.98423056
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95267093
79Abnormality of vitamin metabolism (HP:0100508)1.93859889
80Exercise intolerance (HP:0003546)1.88522733
81Short femoral neck (HP:0100864)1.85647446
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84054871
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82407961
84Abnormal protein N-linked glycosylation (HP:0012347)1.82407961
85Abnormal protein glycosylation (HP:0012346)1.82407961
86Abnormal glycosylation (HP:0012345)1.82407961
87Congenital stationary night blindness (HP:0007642)1.81042402
88Brushfield spots (HP:0001088)1.78579987
89Rhabdomyolysis (HP:0003201)1.76398174
90Abnormality of T cells (HP:0002843)1.75291743
91Respiratory difficulties (HP:0002880)1.75095463
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74304261
93Severe global developmental delay (HP:0011344)1.72288099
94Ulnar deviation of the wrist (HP:0003049)1.71243689
95Enlarged penis (HP:0000040)1.68849349
96Abnormality of renal resorption (HP:0011038)1.68496043
97Abnormality of B cell number (HP:0010975)1.67651068
98Anxiety (HP:0000739)1.67376238
99Panhypogammaglobulinemia (HP:0003139)1.66292909
100Type 2 muscle fiber atrophy (HP:0003554)1.66057379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72644087
2BCKDK3.63528057
3MST43.40328029
4PBK3.25087636
5TAOK33.07775389
6VRK22.86911419
7MAP4K12.83304721
8STK162.64049601
9MAP3K132.63356750
10CDK192.61707405
11ZAK2.51804196
12KDR2.41061092
13TXK2.38951473
14NUAK12.20819176
15FGFR21.90833668
16TLK11.79440682
17MAP3K111.75165256
18VRK11.71495032
19MAPKAPK31.64861760
20WNK41.57675604
21ADRBK21.57086217
22EIF2AK31.53839866
23CDK31.40204887
24NLK1.39914737
25IKBKB1.38504885
26PRKCQ1.36898034
27NME11.28908172
28MAP3K141.28132502
29EIF2AK11.27551820
30NME21.17075448
31ITK1.15579010
32SCYL21.15100407
33PLK31.13962716
34CSNK1G11.13728331
35GRK11.12034092
36PINK11.09945788
37DYRK21.05044579
38MAPK70.97990791
39PASK0.95791118
40INSRR0.94109293
41PLK10.92397052
42TEC0.89713209
43EPHB20.83076668
44TSSK60.82584328
45AURKA0.78823725
46CDC70.75000854
47ABL20.74065098
48SYK0.72717615
49ACVR1B0.72420708
50DAPK10.68721603
51ADRBK10.68123272
52SGK20.66978244
53PIK3CG0.65887846
54RPS6KB20.65590407
55STK40.64149496
56BTK0.64016601
57PLK40.62213258
58PRKG20.62185495
59LCK0.60853781
60ILK0.60849901
61CSF1R0.59232263
62STK390.59230798
63FLT30.59065970
64ATR0.58750755
65CDK40.58020788
66TESK20.56507773
67IKBKE0.54475327
68CHUK0.54272274
69NEK20.53683814
70TIE10.53081505
71MAPKAPK50.52330355
72MAP3K50.51952945
73LYN0.50042241
74TAF10.48788572
75SGK2230.48080563
76SGK4940.48080563
77CSNK2A20.47540199
78KIT0.45540359
79TBK10.45035039
80MAP4K20.43843703
81MYLK0.43751908
82SGK10.42542813
83RPS6KA50.41854712
84MAP3K120.40355848
85CSK0.40302361
86OXSR10.40182467
87CSNK1A10.39624776
88CSNK2A10.39199197
89MAP2K60.38733287
90GRK60.36388624
91NEK10.33060720
92RPS6KA40.29677849
93CSNK1G30.29362579
94BMPR1B0.27952876
95DAPK30.27907976
96PRKCA0.26375574
97RPS6KB10.24961433
98OBSCN0.24941613
99PDK20.24683037
100MAPK150.24107885

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.54270119
2Ribosome_Homo sapiens_hsa030103.30019041
3Sulfur metabolism_Homo sapiens_hsa009203.26098407
4Oxidative phosphorylation_Homo sapiens_hsa001902.87310197
5Primary immunodeficiency_Homo sapiens_hsa053402.62469166
6Allograft rejection_Homo sapiens_hsa053302.56226081
7RNA polymerase_Homo sapiens_hsa030202.51876885
8Parkinsons disease_Homo sapiens_hsa050122.39845337
9Autoimmune thyroid disease_Homo sapiens_hsa053202.33977882
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.26687821
11Asthma_Homo sapiens_hsa053102.24890573
12Protein export_Homo sapiens_hsa030602.18611528
13Base excision repair_Homo sapiens_hsa034102.10546586
14DNA replication_Homo sapiens_hsa030302.06678227
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95264420
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.89993054
17Peroxisome_Homo sapiens_hsa041461.85791499
18Graft-versus-host disease_Homo sapiens_hsa053321.83899288
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83077349
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81917240
21Pyrimidine metabolism_Homo sapiens_hsa002401.75478559
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67871628
23RNA degradation_Homo sapiens_hsa030181.60838625
24Type I diabetes mellitus_Homo sapiens_hsa049401.52725129
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48399944
26Huntingtons disease_Homo sapiens_hsa050161.43416287
27Antigen processing and presentation_Homo sapiens_hsa046121.41548065
28Hematopoietic cell lineage_Homo sapiens_hsa046401.33594349
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32137371
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30822027
31Vitamin digestion and absorption_Homo sapiens_hsa049771.25012485
32T cell receptor signaling pathway_Homo sapiens_hsa046601.24554706
33Homologous recombination_Homo sapiens_hsa034401.24536396
34Alzheimers disease_Homo sapiens_hsa050101.23670676
35Glutathione metabolism_Homo sapiens_hsa004801.23086562
36Fanconi anemia pathway_Homo sapiens_hsa034601.22197209
37Rheumatoid arthritis_Homo sapiens_hsa053231.19187571
38Nucleotide excision repair_Homo sapiens_hsa034201.15320693
39Sulfur relay system_Homo sapiens_hsa041221.12424082
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09569172
41Mismatch repair_Homo sapiens_hsa034301.05618424
42Fat digestion and absorption_Homo sapiens_hsa049751.03542476
43Purine metabolism_Homo sapiens_hsa002301.01595973
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99639397
45One carbon pool by folate_Homo sapiens_hsa006700.98724226
46Linoleic acid metabolism_Homo sapiens_hsa005910.93207563
47Phototransduction_Homo sapiens_hsa047440.91925642
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90941433
49Collecting duct acid secretion_Homo sapiens_hsa049660.90088479
50Retinol metabolism_Homo sapiens_hsa008300.90041107
51Tryptophan metabolism_Homo sapiens_hsa003800.89996749
52Cardiac muscle contraction_Homo sapiens_hsa042600.89680078
53Basal transcription factors_Homo sapiens_hsa030220.87041178
54Spliceosome_Homo sapiens_hsa030400.85532865
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84372800
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79134880
57Caffeine metabolism_Homo sapiens_hsa002320.76739537
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75462841
59Propanoate metabolism_Homo sapiens_hsa006400.73160274
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.72261646
61Fatty acid elongation_Homo sapiens_hsa000620.72060511
62Renin-angiotensin system_Homo sapiens_hsa046140.71784028
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69349706
64Ether lipid metabolism_Homo sapiens_hsa005650.65636246
65Metabolic pathways_Homo sapiens_hsa011000.65051026
66Fatty acid biosynthesis_Homo sapiens_hsa000610.63147495
67Measles_Homo sapiens_hsa051620.62407396
68Chemical carcinogenesis_Homo sapiens_hsa052040.62084794
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60966817
70RNA transport_Homo sapiens_hsa030130.59400287
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59223310
72Arachidonic acid metabolism_Homo sapiens_hsa005900.57353413
73Glycerolipid metabolism_Homo sapiens_hsa005610.53635830
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53366757
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52491569
76Shigellosis_Homo sapiens_hsa051310.50143852
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50122763
78Nitrogen metabolism_Homo sapiens_hsa009100.48766063
79N-Glycan biosynthesis_Homo sapiens_hsa005100.46543353
80Regulation of autophagy_Homo sapiens_hsa041400.45564072
81Folate biosynthesis_Homo sapiens_hsa007900.43308806
82Systemic lupus erythematosus_Homo sapiens_hsa053220.42877869
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.41611150
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40959853
85Selenocompound metabolism_Homo sapiens_hsa004500.39736148
86p53 signaling pathway_Homo sapiens_hsa041150.38538550
87Fatty acid degradation_Homo sapiens_hsa000710.38320188
88Epstein-Barr virus infection_Homo sapiens_hsa051690.37222258
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36291415
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35012382
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30208234
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29776921
93Pyruvate metabolism_Homo sapiens_hsa006200.29636249
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28964108
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28431395
96Arginine and proline metabolism_Homo sapiens_hsa003300.27658938
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.25342630
98Insulin resistance_Homo sapiens_hsa049310.24322512
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.22907497
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22217489

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