RPSAP46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.38050213
2ATP synthesis coupled proton transport (GO:0015986)6.55191513
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.55191513
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99870820
5viral transcription (GO:0019083)5.65824308
6maturation of SSU-rRNA (GO:0030490)5.64061056
7translational termination (GO:0006415)5.39030425
8ribosomal small subunit biogenesis (GO:0042274)5.30698839
9translational elongation (GO:0006414)4.80011567
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79653866
11protein targeting to ER (GO:0045047)4.74104421
12cotranslational protein targeting to membrane (GO:0006613)4.71470549
13protein localization to endoplasmic reticulum (GO:0070972)4.51880398
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.48985352
15water-soluble vitamin biosynthetic process (GO:0042364)4.38593456
16electron transport chain (GO:0022900)4.30155505
17viral life cycle (GO:0019058)4.23977395
18respiratory electron transport chain (GO:0022904)4.23312128
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.21421120
20cellular protein complex disassembly (GO:0043624)4.07853526
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06945172
22response to pheromone (GO:0019236)4.06430301
23DNA deamination (GO:0045006)3.99689727
24translational initiation (GO:0006413)3.94430436
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.85917117
26chaperone-mediated protein transport (GO:0072321)3.74165792
27positive regulation of respiratory burst (GO:0060267)3.70373952
28protein complex biogenesis (GO:0070271)3.67964930
29behavioral response to nicotine (GO:0035095)3.67492017
30translation (GO:0006412)3.67190371
31ATP biosynthetic process (GO:0006754)3.63925241
32purine nucleoside triphosphate biosynthetic process (GO:0009145)3.60409756
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.59597611
34protein neddylation (GO:0045116)3.55770595
35regulation of cellular amino acid metabolic process (GO:0006521)3.52810738
36NADH dehydrogenase complex assembly (GO:0010257)3.49139348
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49139348
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.49139348
39ribosomal large subunit biogenesis (GO:0042273)3.47891358
40GTP biosynthetic process (GO:0006183)3.45893450
41hydrogen ion transmembrane transport (GO:1902600)3.40140378
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35882191
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35882191
44protein complex disassembly (GO:0043241)3.34174582
45regulation of guanylate cyclase activity (GO:0031282)3.33414116
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28590011
47mitochondrial respiratory chain complex assembly (GO:0033108)3.28568952
48respiratory chain complex IV assembly (GO:0008535)3.24337870
49cytidine metabolic process (GO:0046087)3.23008556
50cytidine catabolic process (GO:0006216)3.23008556
51cytidine deamination (GO:0009972)3.23008556
52GDP-mannose metabolic process (GO:0019673)3.17653398
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16069492
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16069492
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16069492
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.16016506
57proton transport (GO:0015992)3.15901295
58ribonucleoprotein complex biogenesis (GO:0022613)3.15830675
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15768128
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15768128
61macromolecular complex disassembly (GO:0032984)3.15129501
62signal peptide processing (GO:0006465)3.14295948
63regulation of immunoglobulin secretion (GO:0051023)3.13357851
64proteasome assembly (GO:0043248)3.12586583
65pseudouridine synthesis (GO:0001522)3.09502604
66cellular component biogenesis (GO:0044085)3.09154570
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08429518
68hydrogen transport (GO:0006818)3.06838140
69sulfation (GO:0051923)3.06607530
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.03333812
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03333812
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01141180
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.00139243
74protein targeting to membrane (GO:0006612)2.99668878
75UTP biosynthetic process (GO:0006228)2.99465133
76regulation of isotype switching to IgG isotypes (GO:0048302)2.98290268
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.97209759
78NADH metabolic process (GO:0006734)2.94094554
79rRNA modification (GO:0000154)2.89153163
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.88266605
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87598362
82rRNA processing (GO:0006364)2.86590661
83UTP metabolic process (GO:0046051)2.84628399
84rRNA metabolic process (GO:0016072)2.83804979
85positive regulation of guanylate cyclase activity (GO:0031284)2.82947257
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.81188203
87mannosylation (GO:0097502)2.77571959
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74889928
89nucleoside triphosphate biosynthetic process (GO:0009142)2.74206890
90cytochrome complex assembly (GO:0017004)2.73979573
91disruption of cells of other organism (GO:0044364)2.72904304
92killing of cells of other organism (GO:0031640)2.72904304
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72308183
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68342502
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68231572
96negative regulation of ligase activity (GO:0051352)2.68231572
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.67012195
98phosphatidylserine acyl-chain remodeling (GO:0036150)2.65083521
99establishment of protein localization to mitochondrion (GO:0072655)2.64866252
100tRNA processing (GO:0008033)2.64639568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.43466271
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.69769326
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62221062
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.59618969
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40841983
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29448522
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.28624564
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09194858
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96837032
10VDR_22108803_ChIP-Seq_LS180_Human2.94315869
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.70392045
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52788350
13ZNF274_21170338_ChIP-Seq_K562_Hela2.37726396
14VDR_23849224_ChIP-Seq_CD4+_Human2.36590219
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32550426
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27159077
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24040093
18FOXP3_21729870_ChIP-Seq_TREG_Human2.08139431
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06390862
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02896220
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98991166
22MYC_18940864_ChIP-ChIP_HL60_Human1.97008446
23TTF2_22483619_ChIP-Seq_HELA_Human1.91732035
24XRN2_22483619_ChIP-Seq_HELA_Human1.82222249
25ELK1_19687146_ChIP-ChIP_HELA_Human1.79125738
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73095598
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.72059075
28IGF1R_20145208_ChIP-Seq_DFB_Human1.67543372
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64220006
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58554490
31DCP1A_22483619_ChIP-Seq_HELA_Human1.58291133
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.57958065
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57566216
34GABP_19822575_ChIP-Seq_HepG2_Human1.57186336
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.56934661
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56439590
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56356610
38EWS_26573619_Chip-Seq_HEK293_Human1.56090205
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47600579
40ERA_21632823_ChIP-Seq_H3396_Human1.46971918
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43955527
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.43955527
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43596032
44TP53_22573176_ChIP-Seq_HFKS_Human1.35418751
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29212606
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28962405
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28728670
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28596261
49TAF2_19829295_ChIP-Seq_ESCs_Human1.23493105
50NANOG_20526341_ChIP-Seq_ESCs_Human1.23183514
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.19520922
52EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18788878
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18576212
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17712839
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15460553
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14881220
57KDM5A_27292631_Chip-Seq_BREAST_Human1.14645569
58NCOR_22424771_ChIP-Seq_293T_Human1.14082520
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13033200
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11357376
61SOX2_19829295_ChIP-Seq_ESCs_Human1.10274470
62NANOG_19829295_ChIP-Seq_ESCs_Human1.10274470
63ERG_20517297_ChIP-Seq_VCAP_Human1.09384199
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09117645
65P53_21459846_ChIP-Seq_SAOS-2_Human1.07853092
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03958686
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03613666
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03376043
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02749419
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.02278357
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01721924
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00565906
73SA1_27219007_Chip-Seq_Bcells_Human1.00486552
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00336934
75BCL6_27268052_Chip-Seq_Bcells_Human1.00315601
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99534551
77MYC_19829295_ChIP-Seq_ESCs_Human0.99400781
78IRF1_19129219_ChIP-ChIP_H3396_Human0.98960808
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97615566
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96352514
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96225913
82AR_20517297_ChIP-Seq_VCAP_Human0.95880316
83P300_27268052_Chip-Seq_Bcells_Human0.95460307
84CTCF_20526341_ChIP-Seq_ESCs_Human0.95047996
85E2F1_20622854_ChIP-Seq_HELA_Human0.94986347
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.93748105
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.93558502
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93214614
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92900537
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92497167
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92367326
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91762815
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90883150
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90594368
95FUS_26573619_Chip-Seq_HEK293_Human0.89599385
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87611416
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86725318
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.85389460
99BCOR_27268052_Chip-Seq_Bcells_Human0.84913090
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83652370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.78858278
2MP0005360_urolithiasis3.21146838
3MP0008875_abnormal_xenobiotic_pharmacok2.96194850
4MP0005075_abnormal_melanosome_morpholog2.76378467
5MP0008872_abnormal_physiological_respon2.38799882
6MP0004147_increased_porphyrin_level2.32188410
7MP0002163_abnormal_gland_morphology2.28725730
8MP0005377_hearing/vestibular/ear_phenot2.15335291
9MP0003878_abnormal_ear_physiology2.15335291
10MP0002138_abnormal_hepatobiliary_system2.15243035
11MP0002102_abnormal_ear_morphology2.13708475
12MP0003718_maternal_effect2.09051258
13MP0003806_abnormal_nucleotide_metabolis2.07511972
14MP0001873_stomach_inflammation2.06733712
15MP0002938_white_spotting2.06116202
16MP0003646_muscle_fatigue2.01336020
17MP0005085_abnormal_gallbladder_physiolo2.00609138
18MP0003283_abnormal_digestive_organ1.96559660
19MP0002095_abnormal_skin_pigmentation1.93401859
20MP0001485_abnormal_pinna_reflex1.91956072
21MP0001666_abnormal_nutrient_absorption1.76081078
22MP0004019_abnormal_vitamin_homeostasis1.75846784
23MP0005084_abnormal_gallbladder_morpholo1.70510832
24MP0005671_abnormal_response_to1.68485621
25MP0005645_abnormal_hypothalamus_physiol1.67779970
26MP0005646_abnormal_pituitary_gland1.66529655
27MP0004742_abnormal_vestibular_system1.66177480
28MP0003186_abnormal_redox_activity1.64076952
29MP0005387_immune_system_phenotype1.61999941
30MP0001790_abnormal_immune_system1.61999941
31MP0006292_abnormal_olfactory_placode1.60055369
32MP0003693_abnormal_embryo_hatching1.56395948
33MP0001986_abnormal_taste_sensitivity1.50947422
34MP0000015_abnormal_ear_pigmentation1.50394868
35MP0004145_abnormal_muscle_electrophysio1.47040548
36MP0005171_absent_coat_pigmentation1.42664820
37MP0001835_abnormal_antigen_presentation1.42569355
38MP0002160_abnormal_reproductive_system1.41436942
39MP0003136_yellow_coat_color1.34955832
40MP0001663_abnormal_digestive_system1.34801263
41MP0004885_abnormal_endolymph1.34685343
42MP0002139_abnormal_hepatobiliary_system1.32645805
43MP0001529_abnormal_vocalization1.30473196
44MP0002148_abnormal_hypersensitivity_rea1.27658738
45MP0004142_abnormal_muscle_tone1.26764511
46MP0002638_abnormal_pupillary_reflex1.25838413
47MP0010155_abnormal_intestine_physiology1.22065110
48MP0003866_abnormal_defecation1.18753650
49MP0000372_irregular_coat_pigmentation1.17577952
50MP0005636_abnormal_mineral_homeostasis1.16037330
51MP0004957_abnormal_blastocyst_morpholog1.15785709
52MP0005551_abnormal_eye_electrophysiolog1.14637714
53MP0005332_abnormal_amino_acid1.13208309
54MP0003183_abnormal_peptide_metabolism1.11339304
55MP0001440_abnormal_grooming_behavior1.11278204
56MP0004043_abnormal_pH_regulation1.10785002
57MP0001968_abnormal_touch/_nociception1.09928154
58MP0001324_abnormal_eye_pigmentation1.09173074
59MP0002876_abnormal_thyroid_physiology1.09147985
60MP0005389_reproductive_system_phenotype1.08705423
61MP0003195_calcinosis1.07786885
62MP0001764_abnormal_homeostasis1.07560016
63MP0009333_abnormal_splenocyte_physiolog1.05330868
64MP0002277_abnormal_respiratory_mucosa1.04183335
65MP0001293_anophthalmia1.03699277
66MP0000538_abnormal_urinary_bladder1.01398865
67MP0006036_abnormal_mitochondrial_physio1.00259789
68MP0005379_endocrine/exocrine_gland_phen0.98522951
69MP0001800_abnormal_humoral_immune0.98235289
70MP0001188_hyperpigmentation0.98009254
71MP0002653_abnormal_ependyma_morphology0.97814516
72MP0008058_abnormal_DNA_repair0.97545427
73MP0009785_altered_susceptibility_to0.96046293
74MP0002735_abnormal_chemical_nociception0.95515475
75MP0003786_premature_aging0.95401614
76MP0001919_abnormal_reproductive_system0.94224061
77MP0002736_abnormal_nociception_after0.93538760
78MP0005381_digestive/alimentary_phenotyp0.92785394
79MP0000490_abnormal_crypts_of0.91966697
80MP0009643_abnormal_urine_homeostasis0.91084434
81MP0008775_abnormal_heart_ventricle0.90717201
82MP0001664_abnormal_digestion0.89733358
83MP0002822_catalepsy0.89129315
84MP0001765_abnormal_ion_homeostasis0.85152895
85MP0001905_abnormal_dopamine_level0.83273283
86MP0005174_abnormal_tail_pigmentation0.83070630
87MP0005365_abnormal_bile_salt0.82794840
88MP0002272_abnormal_nervous_system0.82191421
89MP0003938_abnormal_ear_development0.78752450
90MP0004133_heterotaxia0.78440736
91MP0001756_abnormal_urination0.77820181
92MP0003567_abnormal_fetal_cardiomyocyte0.77087782
93MP0000026_abnormal_inner_ear0.76888053
94MP0002733_abnormal_thermal_nociception0.75368309
95MP0001970_abnormal_pain_threshold0.71465904
96MP0000427_abnormal_hair_cycle0.70634602
97MP0006276_abnormal_autonomic_nervous0.70626534
98MP0003252_abnormal_bile_duct0.70444742
99MP0001348_abnormal_lacrimal_gland0.69835631
100MP0010386_abnormal_urinary_bladder0.68587009

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.49662639
2Lipid accumulation in hepatocytes (HP:0006561)5.19542354
3Reticulocytopenia (HP:0001896)4.84188063
4Acute necrotizing encephalopathy (HP:0006965)4.78887450
5Renal Fanconi syndrome (HP:0001994)4.65575227
6Mitochondrial inheritance (HP:0001427)4.62134250
7Acute encephalopathy (HP:0006846)4.46603215
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.43837931
9Increased CSF lactate (HP:0002490)4.35630557
10Abnormal mitochondria in muscle tissue (HP:0008316)4.15987986
11Increased intramyocellular lipid droplets (HP:0012240)4.01933160
12Hepatocellular necrosis (HP:0001404)4.01381551
13Progressive macrocephaly (HP:0004481)3.98988965
14Exertional dyspnea (HP:0002875)3.86986301
15Hepatic necrosis (HP:0002605)3.80991804
16Increased muscle lipid content (HP:0009058)3.58041303
17Hyperglycinemia (HP:0002154)3.50557129
18Abnormality of urine glucose concentration (HP:0011016)3.47331829
19Glycosuria (HP:0003076)3.47331829
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36871153
21Abnormality of cells of the erythroid lineage (HP:0012130)3.28839253
22Hyperphosphaturia (HP:0003109)3.26908193
23Respiratory difficulties (HP:0002880)3.18216071
24Cerebral edema (HP:0002181)3.14074298
25Hyperglycinuria (HP:0003108)3.12452946
26Macrocytic anemia (HP:0001972)3.11401820
27Abnormality of renal resorption (HP:0011038)3.04702861
28Increased serum lactate (HP:0002151)2.92816696
29Pallor (HP:0000980)2.86113499
30Lethargy (HP:0001254)2.84810222
31Methylmalonic aciduria (HP:0012120)2.84619073
32Abnormal number of erythroid precursors (HP:0012131)2.77659821
33Optic disc pallor (HP:0000543)2.76117864
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72986755
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72986755
36Abnormality of glycine metabolism (HP:0010895)2.71779666
37Abnormality of serine family amino acid metabolism (HP:0010894)2.71779666
38Abnormal hemoglobin (HP:0011902)2.67738348
39Pendular nystagmus (HP:0012043)2.66497824
40Congenital stationary night blindness (HP:0007642)2.64845166
41Absent thumb (HP:0009777)2.62999992
42Abnormal urine phosphate concentration (HP:0012599)2.57573532
43Lactic acidosis (HP:0003128)2.56392047
44Dicarboxylic aciduria (HP:0003215)2.50704880
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50704880
46Methylmalonic acidemia (HP:0002912)2.50072281
47Pancreatic cysts (HP:0001737)2.49168336
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.47256182
49Exercise intolerance (HP:0003546)2.45860383
50Pancytopenia (HP:0001876)2.43898181
51Cleft eyelid (HP:0000625)2.39361473
52Pancreatic fibrosis (HP:0100732)2.36749158
53Leukodystrophy (HP:0002415)2.36324404
54Respiratory failure (HP:0002878)2.30046847
55Abnormality of vitamin B metabolism (HP:0004340)2.29104274
56Abnormality of serum amino acid levels (HP:0003112)2.27337032
57True hermaphroditism (HP:0010459)2.24758824
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22011802
59Generalized aminoaciduria (HP:0002909)2.17531729
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.17113599
61Asplenia (HP:0001746)2.16636597
62Hypoplasia of the ulna (HP:0003022)2.06926591
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05999157
64Congenital sensorineural hearing impairment (HP:0008527)2.04766215
65Degeneration of anterior horn cells (HP:0002398)2.04099756
66Abnormality of the anterior horn cell (HP:0006802)2.04099756
67Molar tooth sign on MRI (HP:0002419)2.03623866
68Abnormality of midbrain morphology (HP:0002418)2.03623866
69Anencephaly (HP:0002323)1.99615069
70Confusion (HP:0001289)1.99263757
71Hypoplasia of the radius (HP:0002984)1.98392896
72IgG deficiency (HP:0004315)1.96160860
73Type I transferrin isoform profile (HP:0003642)1.90825387
743-Methylglutaconic aciduria (HP:0003535)1.89899888
75Renal tubular dysfunction (HP:0000124)1.88618106
76Abnormality of homocysteine metabolism (HP:0010919)1.88476337
77Homocystinuria (HP:0002156)1.88476337
78Abolished electroretinogram (ERG) (HP:0000550)1.86980939
79Nausea (HP:0002018)1.85095137
80Abnormality of the renal cortex (HP:0011035)1.81047637
81Aplasia/Hypoplasia of the ulna (HP:0006495)1.79991116
82Hypoplasia of the pons (HP:0012110)1.79417512
83Renal cortical cysts (HP:0000803)1.78677767
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76015708
85Meckel diverticulum (HP:0002245)1.75026675
86Proximal tubulopathy (HP:0000114)1.74099135
87Forearm undergrowth (HP:0009821)1.73996518
88Increased IgM level (HP:0003496)1.69405480
89Abnormality of the labia minora (HP:0012880)1.69249307
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.68832514
91Short thumb (HP:0009778)1.67424452
92Abnormality of the ileum (HP:0001549)1.67029839
93Congenital, generalized hypertrichosis (HP:0004540)1.66745729
94Hypoalbuminemia (HP:0003073)1.66665591
95Abnormal albumin level (HP:0012116)1.66665591
96Vomiting (HP:0002013)1.65343712
97Alkalosis (HP:0001948)1.65315303
98Abnormality of vitamin metabolism (HP:0100508)1.64092896
99Central scotoma (HP:0000603)1.61872707
100Oral leukoplakia (HP:0002745)1.59896558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.29019044
2ADRBK23.28608570
3MST42.77213559
4TXK2.75135562
5STK162.39070766
6MAP4K22.26632888
7NME12.25983578
8GRK12.18412963
9CDK192.12487294
10WNK42.11934734
11VRK11.92049942
12WNK31.91793565
13TLK11.89110508
14TAF11.88607041
15ACVR1B1.88389323
16PBK1.84338810
17FRK1.78499235
18PINK11.75462173
19TRIM281.74499313
20OXSR11.73255983
21TNIK1.72556145
22PASK1.70346798
23MAP2K61.65656755
24STK391.63894018
25NUAK11.58792064
26NEK11.58205694
27BCKDK1.56789502
28NEK21.55585799
29MAP4K11.53869710
30DYRK21.41830944
31BUB11.41095342
32EIF2AK11.37570425
33ZAK1.26326509
34LMTK21.21025746
35NME21.17789758
36MAP3K121.16166552
37PDK21.13542723
38ADRBK11.10385116
39WEE11.08412252
40PLK31.06815093
41TAOK31.06252986
42LRRK21.03738271
43SRPK11.02021544
44LIMK10.89705214
45TSSK60.89549274
46BMPR1B0.89161546
47MYLK0.88380965
48DAPK10.84792087
49KDR0.83050038
50ABL20.79733314
51IKBKB0.79702364
52ILK0.77064743
53TEC0.71882781
54STK40.71257460
55PLK10.70587973
56DAPK30.69890448
57PRKCG0.69825892
58ITK0.69802109
59SIK20.67582596
60INSRR0.66595162
61STK240.65144793
62GRK50.64506011
63CSNK2A20.61927176
64TGFBR10.61414292
65CSNK2A10.58216804
66PIK3CA0.57186396
67PRKCQ0.53044304
68PLK40.51843446
69AURKB0.51110604
70MAP2K70.50205144
71CCNB10.49130053
72PRKG20.48914681
73ATR0.48057336
74PRKCI0.47518854
75PRKACA0.47195221
76PHKG10.47018823
77PHKG20.47018823
78RPS6KA50.46729761
79GRK70.45157355
80TESK20.43012712
81PRKCH0.41701027
82EPHA20.41224178
83PRKCA0.41222510
84PLK20.41193841
85CDC70.41016668
86MAPKAPK50.39666535
87RPS6KB10.39073645
88PRKCD0.38395346
89SYK0.38239913
90TIE10.37943735
91MINK10.35928009
92CDK80.35121801
93RPS6KA60.34603370
94MKNK20.34582113
95PRKCE0.33732201
96EIF2AK30.33224061
97EIF2AK20.32296898
98MAPK130.31047688
99AURKA0.29887019
100MUSK0.29559692

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39914071
2Proteasome_Homo sapiens_hsa030503.84656261
3Oxidative phosphorylation_Homo sapiens_hsa001903.74101274
4Parkinsons disease_Homo sapiens_hsa050123.07787994
5Asthma_Homo sapiens_hsa053102.59563324
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.15264654
7Huntingtons disease_Homo sapiens_hsa050162.12891699
8Protein export_Homo sapiens_hsa030602.08204011
9Sulfur metabolism_Homo sapiens_hsa009202.05976760
10Fat digestion and absorption_Homo sapiens_hsa049751.99183017
11Alzheimers disease_Homo sapiens_hsa050101.94509269
12Allograft rejection_Homo sapiens_hsa053301.85208819
13Homologous recombination_Homo sapiens_hsa034401.77325397
14RNA polymerase_Homo sapiens_hsa030201.73463724
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71955217
16Autoimmune thyroid disease_Homo sapiens_hsa053201.67070660
17Vitamin digestion and absorption_Homo sapiens_hsa049771.65799727
18DNA replication_Homo sapiens_hsa030301.63276989
19Caffeine metabolism_Homo sapiens_hsa002321.62467860
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50073214
21Cardiac muscle contraction_Homo sapiens_hsa042601.49511821
22Linoleic acid metabolism_Homo sapiens_hsa005911.48645208
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47056441
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.44126740
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41088230
26Mismatch repair_Homo sapiens_hsa034301.38912421
27One carbon pool by folate_Homo sapiens_hsa006701.37593846
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37445343
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35670236
30Peroxisome_Homo sapiens_hsa041461.34404913
31Pyrimidine metabolism_Homo sapiens_hsa002401.33559131
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30809830
33Base excision repair_Homo sapiens_hsa034101.25812609
34Propanoate metabolism_Homo sapiens_hsa006401.22348036
35Chemical carcinogenesis_Homo sapiens_hsa052041.20746147
36Basal transcription factors_Homo sapiens_hsa030221.15253251
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15019851
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09013122
39Fanconi anemia pathway_Homo sapiens_hsa034601.06737373
40Nucleotide excision repair_Homo sapiens_hsa034201.05091898
41Vitamin B6 metabolism_Homo sapiens_hsa007501.03463072
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.02880393
43Purine metabolism_Homo sapiens_hsa002301.01216497
44Primary immunodeficiency_Homo sapiens_hsa053401.00091487
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.96912457
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95194703
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94806049
48Ether lipid metabolism_Homo sapiens_hsa005650.94721545
49Type I diabetes mellitus_Homo sapiens_hsa049400.94308699
50Mineral absorption_Homo sapiens_hsa049780.94001350
51Sulfur relay system_Homo sapiens_hsa041220.92986101
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92519928
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92169942
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91451338
55RNA degradation_Homo sapiens_hsa030180.91411121
56Graft-versus-host disease_Homo sapiens_hsa053320.90096851
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88435692
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.87932727
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85429469
60Glutathione metabolism_Homo sapiens_hsa004800.85226132
61Metabolic pathways_Homo sapiens_hsa011000.81557405
62Retinol metabolism_Homo sapiens_hsa008300.81400139
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80835917
64Arachidonic acid metabolism_Homo sapiens_hsa005900.80100833
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79777860
66Butanoate metabolism_Homo sapiens_hsa006500.79259840
67Phototransduction_Homo sapiens_hsa047440.75077014
68Nitrogen metabolism_Homo sapiens_hsa009100.74468748
69Collecting duct acid secretion_Homo sapiens_hsa049660.74436661
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.74251244
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.73519613
72Folate biosynthesis_Homo sapiens_hsa007900.70025232
73Starch and sucrose metabolism_Homo sapiens_hsa005000.69054198
74Arginine and proline metabolism_Homo sapiens_hsa003300.67574063
75Tryptophan metabolism_Homo sapiens_hsa003800.67189514
76Fatty acid degradation_Homo sapiens_hsa000710.67018769
77Fatty acid biosynthesis_Homo sapiens_hsa000610.66889339
78RNA transport_Homo sapiens_hsa030130.64360675
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57866030
80Fructose and mannose metabolism_Homo sapiens_hsa000510.56961852
81Pyruvate metabolism_Homo sapiens_hsa006200.55984136
82Non-homologous end-joining_Homo sapiens_hsa034500.55888232
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55480829
84Arginine biosynthesis_Homo sapiens_hsa002200.55478822
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54948079
86Renin-angiotensin system_Homo sapiens_hsa046140.53555830
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53298746
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50880431
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49615575
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49139343
91Antigen processing and presentation_Homo sapiens_hsa046120.48614757
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46935497
93Rheumatoid arthritis_Homo sapiens_hsa053230.46895036
94Hematopoietic cell lineage_Homo sapiens_hsa046400.46297325
95Spliceosome_Homo sapiens_hsa030400.44582470
96Fatty acid metabolism_Homo sapiens_hsa012120.42432280
97Selenocompound metabolism_Homo sapiens_hsa004500.41770332
98N-Glycan biosynthesis_Homo sapiens_hsa005100.40369524
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39001854
100Glycerolipid metabolism_Homo sapiens_hsa005610.37147772

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