RPSAP47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.83369674
2viral transcription (GO:0019083)7.20468635
3translational termination (GO:0006415)7.03524128
4translational elongation (GO:0006414)6.17655217
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.85437520
6cotranslational protein targeting to membrane (GO:0006613)5.76407410
7protein targeting to ER (GO:0045047)5.73950444
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.52757714
9ribosomal small subunit biogenesis (GO:0042274)5.50821031
10protein localization to endoplasmic reticulum (GO:0070972)5.41173565
11cellular protein complex disassembly (GO:0043624)5.37805593
12maturation of SSU-rRNA (GO:0030490)5.36829718
13viral life cycle (GO:0019058)5.17579625
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.11512727
15ATP synthesis coupled proton transport (GO:0015986)4.88650832
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.88650832
17DNA deamination (GO:0045006)4.67077843
18protein complex disassembly (GO:0043241)4.58661957
19CTP metabolic process (GO:0046036)4.56565299
20CTP biosynthetic process (GO:0006241)4.56565299
21translational initiation (GO:0006413)4.51679016
22behavioral response to nicotine (GO:0035095)4.44284759
23protein neddylation (GO:0045116)4.42228387
24macromolecular complex disassembly (GO:0032984)4.38917567
25chaperone-mediated protein transport (GO:0072321)4.37015257
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33601093
27pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.15444267
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.08793752
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.08793752
30protein complex biogenesis (GO:0070271)4.02568987
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.01797281
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.99225807
33NADH dehydrogenase complex assembly (GO:0010257)3.99225807
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99225807
35pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.97778398
36translation (GO:0006412)3.97371583
37ribosomal large subunit biogenesis (GO:0042273)3.90897051
38protein targeting to membrane (GO:0006612)3.84509313
39mitochondrial respiratory chain complex assembly (GO:0033108)3.80390999
40pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.76942299
41water-soluble vitamin biosynthetic process (GO:0042364)3.71227170
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69754880
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62373782
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.59493117
45pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.58942510
46nucleotide salvage (GO:0043173)3.58650089
47pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.55062676
48UMP biosynthetic process (GO:0006222)3.55062676
49pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.55062676
50UMP metabolic process (GO:0046049)3.55062676
51ncRNA 3-end processing (GO:0043628)3.49532932
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41319627
53behavioral response to ethanol (GO:0048149)3.40505295
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37131364
55mRNA catabolic process (GO:0006402)3.36656250
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36563556
57pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.35007800
58pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.33227578
59ribonucleoside triphosphate biosynthetic process (GO:0009201)3.33153942
60pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.26355146
61GTP biosynthetic process (GO:0006183)3.20029891
62piRNA metabolic process (GO:0034587)3.17926928
63pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.15863517
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.14592574
65substrate-independent telencephalic tangential migration (GO:0021826)3.14592574
66cellular component biogenesis (GO:0044085)3.12593406
67opioid receptor signaling pathway (GO:0038003)3.12242830
68respiratory electron transport chain (GO:0022904)3.06316680
69preassembly of GPI anchor in ER membrane (GO:0016254)3.06208865
70RNA catabolic process (GO:0006401)3.04619749
71electron transport chain (GO:0022900)3.04413523
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01049904
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00379653
74pyrimidine ribonucleoside metabolic process (GO:0046131)2.98270305
75pyrimidine nucleotide catabolic process (GO:0006244)2.98141137
76base-excision repair, AP site formation (GO:0006285)2.97768038
77epithelial cilium movement (GO:0003351)2.97193220
78purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95821149
79ATP biosynthetic process (GO:0006754)2.94174314
80ribonucleoprotein complex biogenesis (GO:0022613)2.91269618
81nucleoside salvage (GO:0043174)2.89807641
82pyrimidine ribonucleotide metabolic process (GO:0009218)2.88447291
83cell proliferation in forebrain (GO:0021846)2.82171575
84nucleoside triphosphate biosynthetic process (GO:0009142)2.81205467
85cytidine metabolic process (GO:0046087)2.77607031
86cytidine catabolic process (GO:0006216)2.77607031
87cytidine deamination (GO:0009972)2.77607031
88adult feeding behavior (GO:0008343)2.75742174
89glycerophospholipid catabolic process (GO:0046475)2.73925214
90UTP biosynthetic process (GO:0006228)2.73595803
91pyrimidine nucleotide biosynthetic process (GO:0006221)2.71161184
92kynurenine metabolic process (GO:0070189)2.70747398
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70417242
94positive regulation of cAMP-mediated signaling (GO:0043950)2.68246476
95hydrogen ion transmembrane transport (GO:1902600)2.62876108
96protein polyglutamylation (GO:0018095)2.62009488
97negative regulation of calcium ion transport into cytosol (GO:0010523)2.59976038
98UTP metabolic process (GO:0046051)2.59752727
99somite development (GO:0061053)2.59237677
100negative regulation of cAMP-mediated signaling (GO:0043951)2.56449584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50043309
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.43235598
3VDR_22108803_ChIP-Seq_LS180_Human3.19063990
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94787790
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63125967
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61977181
7ZNF274_21170338_ChIP-Seq_K562_Hela2.41281354
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.39163155
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37047460
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.23082435
11IRF1_19129219_ChIP-ChIP_H3396_Human2.13323647
12IGF1R_20145208_ChIP-Seq_DFB_Human2.10888224
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07020726
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04574582
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86527255
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79346564
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.77556717
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75566868
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73320167
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.65967345
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62056735
22VDR_23849224_ChIP-Seq_CD4+_Human1.60042941
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59120662
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.58588860
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57033297
26MYC_18940864_ChIP-ChIP_HL60_Human1.54334598
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.53697071
28TP53_22573176_ChIP-Seq_HFKS_Human1.51051216
29FOXP3_21729870_ChIP-Seq_TREG_Human1.49277607
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48326457
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47104531
32ERA_21632823_ChIP-Seq_H3396_Human1.45006923
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.43739554
34TTF2_22483619_ChIP-Seq_HELA_Human1.43094898
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41224224
36EWS_26573619_Chip-Seq_HEK293_Human1.39450041
37NANOG_20526341_ChIP-Seq_ESCs_Human1.39157677
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38285943
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37869762
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35974007
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.34507477
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33444602
43RNF2_27304074_Chip-Seq_NSC_Mouse1.31264055
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31168284
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30821072
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28778708
47NCOR_22424771_ChIP-Seq_293T_Human1.27049201
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26149680
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.25546379
50REST_21632747_ChIP-Seq_MESCs_Mouse1.23414295
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23124932
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22880835
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21506171
54ELK1_19687146_ChIP-ChIP_HELA_Human1.19319255
55SOX2_19829295_ChIP-Seq_ESCs_Human1.18551695
56NANOG_19829295_ChIP-Seq_ESCs_Human1.18551695
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.18538597
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18418046
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18058859
60TAF2_19829295_ChIP-Seq_ESCs_Human1.17860335
61SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17818487
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16977981
63P53_21459846_ChIP-Seq_SAOS-2_Human1.16733093
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.15951294
65CBP_20019798_ChIP-Seq_JUKART_Human1.12985275
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12985275
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12589375
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12353027
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12080598
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11455032
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10955251
72GABP_19822575_ChIP-Seq_HepG2_Human1.09728202
73AR_20517297_ChIP-Seq_VCAP_Human1.06950145
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06814059
75GATA3_21867929_ChIP-Seq_TH1_Mouse1.06287795
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06154381
77FUS_26573619_Chip-Seq_HEK293_Human1.05669184
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.05659110
79TAF15_26573619_Chip-Seq_HEK293_Human1.04640051
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04375202
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.04375202
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04334037
83P300_19829295_ChIP-Seq_ESCs_Human1.03933458
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02907317
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.01932401
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00545909
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00191837
88MYC_19829295_ChIP-Seq_ESCs_Human0.99355211
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98274231
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97681586
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97618487
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.95897213
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95077434
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.94068494
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93986811
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93851055
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92857858
98HTT_18923047_ChIP-ChIP_STHdh_Human0.92306022
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92016274
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91783838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.39102661
2MP0006292_abnormal_olfactory_placode4.33369084
3MP0002163_abnormal_gland_morphology3.24235697
4MP0003787_abnormal_imprinting3.09479474
5MP0003646_muscle_fatigue2.82854452
6MP0008877_abnormal_DNA_methylation2.76977608
7MP0002876_abnormal_thyroid_physiology2.37884675
8MP0003122_maternal_imprinting2.30239884
9MP0008789_abnormal_olfactory_epithelium2.21707739
10MP0008875_abnormal_xenobiotic_pharmacok2.09698405
11MP0005645_abnormal_hypothalamus_physiol2.02842302
12MP0001968_abnormal_touch/_nociception1.96483644
13MP0001348_abnormal_lacrimal_gland1.90848519
14MP0005379_endocrine/exocrine_gland_phen1.88206230
15MP0005377_hearing/vestibular/ear_phenot1.85480309
16MP0003878_abnormal_ear_physiology1.85480309
17MP0005551_abnormal_eye_electrophysiolog1.80883546
18MP0002653_abnormal_ependyma_morphology1.80853011
19MP0002102_abnormal_ear_morphology1.76691376
20MP0003123_paternal_imprinting1.75099300
21MP0004142_abnormal_muscle_tone1.74932077
22MP0004885_abnormal_endolymph1.71262523
23MP0003880_abnormal_central_pattern1.70977634
24MP0005646_abnormal_pituitary_gland1.67847485
25MP0001485_abnormal_pinna_reflex1.64546711
26MP0006276_abnormal_autonomic_nervous1.64024616
27MP0000049_abnormal_middle_ear1.62527978
28MP0008872_abnormal_physiological_respon1.61674627
29MP0003121_genomic_imprinting1.59943839
30MP0005394_taste/olfaction_phenotype1.59806407
31MP0005499_abnormal_olfactory_system1.59806407
32MP0005360_urolithiasis1.55963998
33MP0006072_abnormal_retinal_apoptosis1.55633041
34MP0001529_abnormal_vocalization1.54102340
35MP0002837_dystrophic_cardiac_calcinosis1.50280315
36MP0002272_abnormal_nervous_system1.42478255
37MP0001293_anophthalmia1.32008260
38MP0001986_abnormal_taste_sensitivity1.29542262
39MP0005084_abnormal_gallbladder_morpholo1.29234746
40MP0002234_abnormal_pharynx_morphology1.25984172
41MP0005389_reproductive_system_phenotype1.25742167
42MP0003567_abnormal_fetal_cardiomyocyte1.25061120
43MP0004742_abnormal_vestibular_system1.24635122
44MP0001905_abnormal_dopamine_level1.24148674
45MP0004147_increased_porphyrin_level1.22038313
46MP0002095_abnormal_skin_pigmentation1.20621581
47MP0000678_abnormal_parathyroid_gland1.20211485
48MP0002733_abnormal_thermal_nociception1.17860591
49MP0001919_abnormal_reproductive_system1.16120025
50MP0009745_abnormal_behavioral_response1.14512109
51MP0009764_decreased_sensitivity_to1.12923678
52MP0004145_abnormal_muscle_electrophysio1.12157497
53MP0002138_abnormal_hepatobiliary_system1.08467452
54MP0002938_white_spotting1.07971290
55MP0002557_abnormal_social/conspecific_i1.07844408
56MP0008775_abnormal_heart_ventricle1.07493055
57MP0001970_abnormal_pain_threshold1.07183112
58MP0002160_abnormal_reproductive_system1.06746587
59MP0005195_abnormal_posterior_eye1.05000657
60MP0002736_abnormal_nociception_after1.02887969
61MP0003195_calcinosis1.00691870
62MP0003879_abnormal_hair_cell0.98806119
63MP0008058_abnormal_DNA_repair0.98177754
64MP0003183_abnormal_peptide_metabolism0.96587820
65MP0004133_heterotaxia0.94833295
66MP0001501_abnormal_sleep_pattern0.90075298
67MP0002752_abnormal_somatic_nervous0.90007260
68MP0000631_abnormal_neuroendocrine_gland0.89513144
69MP0000026_abnormal_inner_ear0.88485093
70MP0000778_abnormal_nervous_system0.88268645
71MP0005671_abnormal_response_to0.88053669
72MP0001440_abnormal_grooming_behavior0.84092484
73MP0002638_abnormal_pupillary_reflex0.82686090
74MP0005423_abnormal_somatic_nervous0.82332489
75MP0009046_muscle_twitch0.82103940
76MP0000230_abnormal_systemic_arterial0.80489681
77MP0001963_abnormal_hearing_physiology0.80482849
78MP0001664_abnormal_digestion0.79908084
79MP0003186_abnormal_redox_activity0.79501646
80MP0005253_abnormal_eye_physiology0.79396477
81MP0001764_abnormal_homeostasis0.79364340
82MP0002210_abnormal_sex_determination0.79101118
83MP0001486_abnormal_startle_reflex0.76365528
84MP0003937_abnormal_limbs/digits/tail_de0.75590021
85MP0003011_delayed_dark_adaptation0.75579765
86MP0002184_abnormal_innervation0.75560866
87MP0002572_abnormal_emotion/affect_behav0.75280872
88MP0003119_abnormal_digestive_system0.71783011
89MP0001984_abnormal_olfaction0.70110827
90MP0009278_abnormal_bone_marrow0.70098736
91MP0001663_abnormal_digestive_system0.69922943
92MP0001873_stomach_inflammation0.69662742
93MP0003635_abnormal_synaptic_transmissio0.69397867
94MP0006035_abnormal_mitochondrial_morpho0.69259119
95MP0002693_abnormal_pancreas_physiology0.68865935
96MP0000538_abnormal_urinary_bladder0.67754337
97MP0002735_abnormal_chemical_nociception0.67620591
98MP0009333_abnormal_splenocyte_physiolog0.67505632
99MP0004043_abnormal_pH_regulation0.66508568
100MP0005332_abnormal_amino_acid0.66486691

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.44230526
2Reticulocytopenia (HP:0001896)4.13683558
3Abnormality of cells of the erythroid lineage (HP:0012130)3.91736538
4Acute encephalopathy (HP:0006846)3.88123124
5Thyroid-stimulating hormone excess (HP:0002925)3.85806391
6Abnormal mitochondria in muscle tissue (HP:0008316)3.79064606
7Mitochondrial inheritance (HP:0001427)3.67879782
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.65879032
9Progressive macrocephaly (HP:0004481)3.52064647
10Pancreatic fibrosis (HP:0100732)3.46633823
11Increased CSF lactate (HP:0002490)3.40521439
12Macrocytic anemia (HP:0001972)3.34804855
13Abnormality of midbrain morphology (HP:0002418)3.32605557
14Molar tooth sign on MRI (HP:0002419)3.32605557
15Abnormal number of erythroid precursors (HP:0012131)3.28745430
16Increased hepatocellular lipid droplets (HP:0006565)3.03301896
17Hyperglycinemia (HP:0002154)2.98987199
18Pancreatic cysts (HP:0001737)2.96965598
19Aplasia/Hypoplasia of the spleen (HP:0010451)2.91002059
20Lipid accumulation in hepatocytes (HP:0006561)2.90696775
21Abnormal rod and cone electroretinograms (HP:0008323)2.90581780
22Cerebral edema (HP:0002181)2.87459856
23Asplenia (HP:0001746)2.85257953
24Pallor (HP:0000980)2.84978525
253-Methylglutaconic aciduria (HP:0003535)2.67196777
26True hermaphroditism (HP:0010459)2.65282294
27Hepatocellular necrosis (HP:0001404)2.63260543
28Elevated erythrocyte sedimentation rate (HP:0003565)2.61484628
29Absent/shortened dynein arms (HP:0200106)2.59381632
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.59381632
31Optic disc pallor (HP:0000543)2.57515292
32Intestinal atresia (HP:0011100)2.57074016
33Agitation (HP:0000713)2.53760737
34Medial flaring of the eyebrow (HP:0010747)2.51471764
35Pendular nystagmus (HP:0012043)2.50806093
36Rib fusion (HP:0000902)2.48020673
37Nephronophthisis (HP:0000090)2.46227518
38Colon cancer (HP:0003003)2.45529381
39Congenital stationary night blindness (HP:0007642)2.44630316
40Tubular atrophy (HP:0000092)2.44005871
41Supernumerary spleens (HP:0009799)2.41686741
42Renal Fanconi syndrome (HP:0001994)2.41106198
43Hepatic necrosis (HP:0002605)2.40526910
44Sclerocornea (HP:0000647)2.40524530
45Hip dysplasia (HP:0001385)2.39464553
46Abnormal respiratory motile cilium morphology (HP:0005938)2.29544117
47Abnormal respiratory epithelium morphology (HP:0012253)2.29544117
48Abnormality of DNA repair (HP:0003254)2.25126500
49Hyperthyroidism (HP:0000836)2.22739493
50Abnormal hemoglobin (HP:0011902)2.22185937
51Abnormal ciliary motility (HP:0012262)2.21970176
52Abolished electroretinogram (ERG) (HP:0000550)2.18870048
53Type II lissencephaly (HP:0007260)2.18284219
54Abnormality of the renal medulla (HP:0100957)2.14019181
55Absent thumb (HP:0009777)2.12962452
56Methylmalonic acidemia (HP:0002912)2.11184785
57Cystic liver disease (HP:0006706)2.11163730
58Abnormal respiratory motile cilium physiology (HP:0012261)2.10333745
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09586794
60Increased intramyocellular lipid droplets (HP:0012240)2.09084008
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08783416
62Increased serum lactate (HP:0002151)2.08595853
63Gait imbalance (HP:0002141)2.00203368
64Abnormality of the metopic suture (HP:0005556)2.00080845
65Polydipsia (HP:0001959)1.99095328
66Abnormal drinking behavior (HP:0030082)1.99095328
67Congenital primary aphakia (HP:0007707)1.97143743
68Abnormal biliary tract physiology (HP:0012439)1.96495201
69Bile duct proliferation (HP:0001408)1.96495201
70Prominent metopic ridge (HP:0005487)1.96206895
71Methylmalonic aciduria (HP:0012120)1.94061734
72Exertional dyspnea (HP:0002875)1.93882241
73Anencephaly (HP:0002323)1.92238831
74Polyuria (HP:0000103)1.89938271
75Metaphyseal dysplasia (HP:0100255)1.89697371
76Pancreatic islet-cell hyperplasia (HP:0004510)1.89668400
77Lactic acidosis (HP:0003128)1.87032907
78Optic nerve hypoplasia (HP:0000609)1.87029542
79Postaxial foot polydactyly (HP:0001830)1.86238630
80Abnormality of the renal cortex (HP:0011035)1.85075450
81Nephrogenic diabetes insipidus (HP:0009806)1.85022882
82Depressed nasal ridge (HP:0000457)1.84892075
83Abnormality of renal resorption (HP:0011038)1.84579924
84Type 2 muscle fiber atrophy (HP:0003554)1.84399067
85Broad alveolar ridges (HP:0000187)1.84332739
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83752567
87Lethargy (HP:0001254)1.83221192
88Abnormality of the aortic arch (HP:0012303)1.81460371
89Constricted visual fields (HP:0001133)1.81190557
90Septo-optic dysplasia (HP:0100842)1.79504343
91Increased muscle lipid content (HP:0009058)1.79418047
92Hypomagnesemia (HP:0002917)1.77059358
93Anophthalmia (HP:0000528)1.76292790
94Stenosis of the external auditory canal (HP:0000402)1.74947181
95Respiratory failure (HP:0002878)1.74830228
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.73862971
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73682228
98Increased corneal curvature (HP:0100692)1.73304795
99Keratoconus (HP:0000563)1.73304795
100Hypoplasia of the radius (HP:0002984)1.72452343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.71514518
2MAP4K24.70139102
3FRK2.65205721
4STK162.63914574
5GRK12.62027049
6BMPR1B2.50032306
7CDK192.35702731
8BCKDK2.33815785
9TIE12.17794804
10VRK22.15302139
11WNK42.09296444
12LIMK12.09261391
13DYRK22.07266263
14PINK11.97692290
15NUAK11.94604247
16TLK11.82131038
17ZAK1.81074293
18PRKCG1.57152623
19TXK1.53042741
20ADRBK11.44216588
21WNK31.37995275
22PASK1.22972931
23INSRR1.19486738
24TGFBR11.17661596
25MAP4K11.14589433
26PIK3CA1.10626558
27TAOK31.09150178
28VRK11.04684300
29EPHB20.95811868
30CAMK10.93367401
31ACVR1B0.92711723
32MAP3K110.92138124
33STK390.92006716
34MUSK0.91824430
35TAF10.91334512
36LRRK20.90840740
37KDR0.88564819
38TEC0.86775974
39PRKCQ0.85260733
40OXSR10.83797204
41AURKA0.82348625
42CSNK2A20.82199220
43MAP3K120.81790578
44CDC70.81398685
45CSNK1G10.80870447
46DYRK30.78089684
47MAP2K70.75327609
48ITK0.74552713
49DAPK30.74003155
50FLT30.68396465
51PLK20.68004030
52EPHA40.66324738
53CSNK1G30.66301033
54CAMKK20.65864509
55PRKACA0.65323664
56STK110.65095439
57PRKCE0.63723791
58PLK10.62084560
59PRKCI0.61998569
60NEK10.60510957
61PRKCH0.60073234
62AURKB0.59946149
63MINK10.59435335
64CSNK2A10.59117539
65CSNK1G20.58796509
66CSNK1A10.57499732
67BTK0.57274474
68PRKCA0.56751141
69TYRO30.56378148
70MAPK130.55844291
71MKNK20.55547061
72MKNK10.55367356
73RPS6KA50.55058219
74PRKD30.55033998
75PLK40.52520504
76OBSCN0.51832316
77CAMK2A0.50980931
78NME20.49571049
79TNIK0.49423714
80IKBKB0.49232355
81NTRK20.48809565
82NME10.47525483
83MAP3K40.46538955
84GRK50.45679844
85KIT0.44890046
86PDK20.44757718
87MYLK0.44622744
88CSF1R0.43541067
89CSNK1E0.43009254
90CSNK1A1L0.42362206
91PRKCD0.41102874
92CHEK20.39091184
93CAMK40.38941524
94LCK0.38472854
95RPS6KA60.37892969
96ATR0.36823687
97GRK70.36707265
98DYRK1A0.35804426
99ABL20.35285208
100PRKACG0.34442892

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.10197877
2Oxidative phosphorylation_Homo sapiens_hsa001903.61050159
3Parkinsons disease_Homo sapiens_hsa050122.97436369
4Sulfur relay system_Homo sapiens_hsa041222.77863798
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49255078
6RNA polymerase_Homo sapiens_hsa030202.30209656
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19408505
8Huntingtons disease_Homo sapiens_hsa050162.16083376
9Cardiac muscle contraction_Homo sapiens_hsa042602.09374941
10Linoleic acid metabolism_Homo sapiens_hsa005912.05264083
11Alzheimers disease_Homo sapiens_hsa050101.99762056
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91175132
13Phototransduction_Homo sapiens_hsa047441.86612186
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76201030
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75611555
16Proteasome_Homo sapiens_hsa030501.72915552
17Pyrimidine metabolism_Homo sapiens_hsa002401.70286340
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65759458
19Protein export_Homo sapiens_hsa030601.59364904
20Butanoate metabolism_Homo sapiens_hsa006501.43275688
21Homologous recombination_Homo sapiens_hsa034401.40039496
22RNA degradation_Homo sapiens_hsa030181.29104796
23Asthma_Homo sapiens_hsa053101.29090294
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28473181
25Fat digestion and absorption_Homo sapiens_hsa049751.27263328
26Propanoate metabolism_Homo sapiens_hsa006401.25214106
27Basal transcription factors_Homo sapiens_hsa030221.21620067
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.21137784
29Base excision repair_Homo sapiens_hsa034101.19481466
30Fanconi anemia pathway_Homo sapiens_hsa034601.13594175
31Primary immunodeficiency_Homo sapiens_hsa053401.13171270
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.12398138
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12031626
34Nicotine addiction_Homo sapiens_hsa050331.10385890
35One carbon pool by folate_Homo sapiens_hsa006701.07967395
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06874731
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.05099240
38Purine metabolism_Homo sapiens_hsa002301.04290876
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03723744
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.03363237
41Nucleotide excision repair_Homo sapiens_hsa034201.03099169
42Peroxisome_Homo sapiens_hsa041461.02369066
43Tryptophan metabolism_Homo sapiens_hsa003801.00854249
44Arachidonic acid metabolism_Homo sapiens_hsa005901.00468863
45Olfactory transduction_Homo sapiens_hsa047400.97411806
46Glycerolipid metabolism_Homo sapiens_hsa005610.91140947
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89566874
48DNA replication_Homo sapiens_hsa030300.89212396
49Metabolic pathways_Homo sapiens_hsa011000.88088211
50Allograft rejection_Homo sapiens_hsa053300.87934984
51Autoimmune thyroid disease_Homo sapiens_hsa053200.86508026
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86325253
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86200974
54Ether lipid metabolism_Homo sapiens_hsa005650.84984955
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.84167201
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81686985
57Nitrogen metabolism_Homo sapiens_hsa009100.81171637
58Steroid biosynthesis_Homo sapiens_hsa001000.79418996
59Morphine addiction_Homo sapiens_hsa050320.79306658
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77854788
61Caffeine metabolism_Homo sapiens_hsa002320.76898491
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76612369
63Sulfur metabolism_Homo sapiens_hsa009200.75732742
64Graft-versus-host disease_Homo sapiens_hsa053320.72687494
65Retinol metabolism_Homo sapiens_hsa008300.69780032
66Ovarian steroidogenesis_Homo sapiens_hsa049130.69074412
67Mismatch repair_Homo sapiens_hsa034300.66777318
68RNA transport_Homo sapiens_hsa030130.65999407
69Chemical carcinogenesis_Homo sapiens_hsa052040.65495081
70Type I diabetes mellitus_Homo sapiens_hsa049400.64975673
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64195934
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63300860
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60539338
74Hematopoietic cell lineage_Homo sapiens_hsa046400.59697924
75Non-homologous end-joining_Homo sapiens_hsa034500.58920140
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53710695
77Pentose phosphate pathway_Homo sapiens_hsa000300.53594521
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53428779
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.52641059
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52244011
81Basal cell carcinoma_Homo sapiens_hsa052170.51022471
82beta-Alanine metabolism_Homo sapiens_hsa004100.48588957
83Arginine and proline metabolism_Homo sapiens_hsa003300.45342655
84Collecting duct acid secretion_Homo sapiens_hsa049660.43897807
85Fatty acid degradation_Homo sapiens_hsa000710.43419567
86Serotonergic synapse_Homo sapiens_hsa047260.41377270
87Systemic lupus erythematosus_Homo sapiens_hsa053220.39993527
88Taste transduction_Homo sapiens_hsa047420.38859518
89Salivary secretion_Homo sapiens_hsa049700.38251976
90Starch and sucrose metabolism_Homo sapiens_hsa005000.37975469
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36250498
92Glutathione metabolism_Homo sapiens_hsa004800.35822562
93Insulin secretion_Homo sapiens_hsa049110.34984445
94Pyruvate metabolism_Homo sapiens_hsa006200.34026937
95Dorso-ventral axis formation_Homo sapiens_hsa043200.32401606
96Hedgehog signaling pathway_Homo sapiens_hsa043400.30983029
97Rheumatoid arthritis_Homo sapiens_hsa053230.29297839
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28376241
99Selenocompound metabolism_Homo sapiens_hsa004500.28154233
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28145397

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