RPSAP49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.44559751
2DNA deamination (GO:0045006)6.55100413
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22244942
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.81676498
5ATP synthesis coupled proton transport (GO:0015986)5.81676498
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.32771946
7cytidine metabolic process (GO:0046087)5.27460161
8cytidine catabolic process (GO:0006216)5.27460161
9cytidine deamination (GO:0009972)5.27460161
10viral transcription (GO:0019083)4.99876441
11translational termination (GO:0006415)4.82778167
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.78143160
13pyrimidine ribonucleoside catabolic process (GO:0046133)4.58013698
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57076216
15translational elongation (GO:0006414)4.37812923
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.36710212
17respiratory electron transport chain (GO:0022904)4.33045789
18electron transport chain (GO:0022900)4.30107246
19cotranslational protein targeting to membrane (GO:0006613)4.28365153
20protein targeting to ER (GO:0045047)4.27502294
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06746945
22protein localization to endoplasmic reticulum (GO:0070972)4.06527274
23chaperone-mediated protein transport (GO:0072321)3.87936898
24water-soluble vitamin biosynthetic process (GO:0042364)3.83348212
25ribosomal small subunit biogenesis (GO:0042274)3.82088164
26protein complex biogenesis (GO:0070271)3.81762124
27protein neddylation (GO:0045116)3.80579733
28translational initiation (GO:0006413)3.66934127
29pseudouridine synthesis (GO:0001522)3.66725276
30proteasome assembly (GO:0043248)3.63820500
31viral life cycle (GO:0019058)3.61270143
32cellular protein complex disassembly (GO:0043624)3.60679820
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.58074893
34NADH dehydrogenase complex assembly (GO:0010257)3.58074893
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58074893
36translation (GO:0006412)3.53866774
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52666652
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51884150
39ribosomal large subunit biogenesis (GO:0042273)3.51677767
40rRNA modification (GO:0000154)3.51430032
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50408786
42mitochondrial respiratory chain complex assembly (GO:0033108)3.46951791
43maturation of SSU-rRNA (GO:0030490)3.46255849
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37302145
45ATP biosynthetic process (GO:0006754)3.36164250
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36040685
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30312920
48regulation of cellular amino acid metabolic process (GO:0006521)3.30138253
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26284899
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26284899
51respiratory chain complex IV assembly (GO:0008535)3.23680771
52hydrogen ion transmembrane transport (GO:1902600)3.17332129
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17235290
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.14558770
55platelet dense granule organization (GO:0060155)3.13316918
56behavioral response to nicotine (GO:0035095)3.06907343
57termination of RNA polymerase III transcription (GO:0006386)3.03325095
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.03325095
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03111463
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01893779
61actin nucleation (GO:0045010)3.01730270
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00885076
63negative regulation of ligase activity (GO:0051352)3.00885076
64cytochrome complex assembly (GO:0017004)2.96813069
65pyrimidine nucleotide catabolic process (GO:0006244)2.94925416
66iron-sulfur cluster assembly (GO:0016226)2.92373715
67metallo-sulfur cluster assembly (GO:0031163)2.92373715
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91561624
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91561624
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91561624
71cellular component biogenesis (GO:0044085)2.91043357
72protein complex disassembly (GO:0043241)2.90460614
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89699157
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89699157
75mannosylation (GO:0097502)2.89278075
76response to interferon-beta (GO:0035456)2.87013148
77proton transport (GO:0015992)2.86975043
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84442326
79hydrogen transport (GO:0006818)2.82595743
80base-excision repair, AP site formation (GO:0006285)2.80462702
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.79938506
82deoxyribonucleotide catabolic process (GO:0009264)2.79782123
83deoxyribose phosphate catabolic process (GO:0046386)2.79296251
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79209096
85rRNA processing (GO:0006364)2.77991479
86macromolecular complex disassembly (GO:0032984)2.77164350
87rRNA methylation (GO:0031167)2.75228712
88rRNA metabolic process (GO:0016072)2.74018837
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.73897897
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73897897
91protein targeting to membrane (GO:0006612)2.72813388
92ribonucleoprotein complex biogenesis (GO:0022613)2.71193755
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.69037475
94negative regulation of calcium ion transport into cytosol (GO:0010523)2.68509052
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66340261
96GPI anchor biosynthetic process (GO:0006506)2.63503532
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.62674761
98mRNA catabolic process (GO:0006402)2.62130676
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61453982
100sequestering of actin monomers (GO:0042989)2.60353451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.24318322
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14702588
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.96375326
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.55734722
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52236964
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37739510
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33388644
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94748577
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84549179
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82510031
11VDR_22108803_ChIP-Seq_LS180_Human2.73190174
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.71844400
13VDR_23849224_ChIP-Seq_CD4+_Human2.66168230
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51897888
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.50079312
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.28798618
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18661498
18FOXP3_21729870_ChIP-Seq_TREG_Human2.13841653
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10994622
20IGF1R_20145208_ChIP-Seq_DFB_Human2.07077427
21ELK1_19687146_ChIP-ChIP_HELA_Human2.06328417
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05980193
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96326905
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94679351
25EZH2_22144423_ChIP-Seq_EOC_Human1.91880951
26ZNF274_21170338_ChIP-Seq_K562_Hela1.88333186
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86141769
28MYC_18940864_ChIP-ChIP_HL60_Human1.82991402
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.74336187
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73017107
31EWS_26573619_Chip-Seq_HEK293_Human1.69687484
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.59038851
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.53521378
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.48572344
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46611555
36IRF1_19129219_ChIP-ChIP_H3396_Human1.46199520
37TP53_22573176_ChIP-Seq_HFKS_Human1.45638611
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43084450
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.40711969
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40711969
41FUS_26573619_Chip-Seq_HEK293_Human1.40138303
42TTF2_22483619_ChIP-Seq_HELA_Human1.39474295
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34742298
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34232221
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.32083799
46MYB_26560356_Chip-Seq_TH2_Human1.31614752
47AR_20517297_ChIP-Seq_VCAP_Human1.30898114
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30644157
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29611166
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29176033
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28350477
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27496809
53GATA3_26560356_Chip-Seq_TH2_Human1.27219330
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23195443
55NCOR_22424771_ChIP-Seq_293T_Human1.21651699
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21255221
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19513114
58SOX2_19829295_ChIP-Seq_ESCs_Human1.18979899
59NANOG_19829295_ChIP-Seq_ESCs_Human1.18979899
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18142285
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16931376
62NANOG_20526341_ChIP-Seq_ESCs_Human1.16560742
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15232213
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14844846
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14175855
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11526413
67CIITA_25753668_ChIP-Seq_RAJI_Human1.10257983
68ERG_20517297_ChIP-Seq_VCAP_Human1.08017082
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07496632
70TAF2_19829295_ChIP-Seq_ESCs_Human1.04916462
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03944194
72DCP1A_22483619_ChIP-Seq_HELA_Human1.03784390
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03342147
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02821657
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02283778
76GABP_19822575_ChIP-Seq_HepG2_Human1.02267769
77P300_19829295_ChIP-Seq_ESCs_Human1.02057394
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.01202492
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01135550
80HTT_18923047_ChIP-ChIP_STHdh_Human1.00294228
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99800023
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99609448
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99131382
84ER_23166858_ChIP-Seq_MCF-7_Human0.99091056
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.99066122
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97426922
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96059201
88E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95414997
89MYC_19829295_ChIP-Seq_ESCs_Human0.94966402
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94136370
91CBP_20019798_ChIP-Seq_JUKART_Human0.94126201
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94126201
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93861876
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92443454
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92057085
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91524064
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.90675500
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90212008
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88835045
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88097151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.16945041
2MP0005671_abnormal_response_to3.65436945
3MP0001835_abnormal_antigen_presentation3.05035384
4MP0006292_abnormal_olfactory_placode2.91100934
5MP0009333_abnormal_splenocyte_physiolog2.59097817
6MP0002102_abnormal_ear_morphology2.54274809
7MP0002138_abnormal_hepatobiliary_system2.36575275
8MP0009785_altered_susceptibility_to2.33658090
9MP0001873_stomach_inflammation2.25194163
10MP0005084_abnormal_gallbladder_morpholo2.24888517
11MP0000372_irregular_coat_pigmentation2.19528923
12MP0006072_abnormal_retinal_apoptosis2.12024036
13MP0002837_dystrophic_cardiac_calcinosis1.87406728
14MP0004147_increased_porphyrin_level1.86259076
15MP0008877_abnormal_DNA_methylation1.82487238
16MP0002148_abnormal_hypersensitivity_rea1.81457503
17MP0002166_altered_tumor_susceptibility1.79361772
18MP0003763_abnormal_thymus_physiology1.74225800
19MP0001800_abnormal_humoral_immune1.72173463
20MP0000685_abnormal_immune_system1.65782965
21MP0008872_abnormal_physiological_respon1.60271372
22MP0003786_premature_aging1.59541110
23MP0005646_abnormal_pituitary_gland1.57511846
24MP0005551_abnormal_eye_electrophysiolog1.57057774
25MP0005645_abnormal_hypothalamus_physiol1.51741378
26MP0005075_abnormal_melanosome_morpholog1.51321451
27MP0008875_abnormal_xenobiotic_pharmacok1.50807865
28MP0002006_tumorigenesis1.49601919
29MP0001905_abnormal_dopamine_level1.48477312
30MP0005387_immune_system_phenotype1.46549207
31MP0001790_abnormal_immune_system1.46549207
32MP0003646_muscle_fatigue1.44839799
33MP0005000_abnormal_immune_tolerance1.43462592
34MP0008995_early_reproductive_senescence1.42318040
35MP0004142_abnormal_muscle_tone1.40784892
36MP0001764_abnormal_homeostasis1.39867826
37MP0002163_abnormal_gland_morphology1.39573194
38MP0002638_abnormal_pupillary_reflex1.39459232
39MP0003787_abnormal_imprinting1.38452138
40MP0002723_abnormal_immune_serum1.37900008
41MP0005379_endocrine/exocrine_gland_phen1.37083503
42MP0003567_abnormal_fetal_cardiomyocyte1.36858744
43MP0002420_abnormal_adaptive_immunity1.33431498
44MP0001819_abnormal_immune_cell1.30229857
45MP0005253_abnormal_eye_physiology1.27012754
46MP0001188_hyperpigmentation1.26689395
47MP0001986_abnormal_taste_sensitivity1.26427888
48MP0005389_reproductive_system_phenotype1.24725740
49MP0002277_abnormal_respiratory_mucosa1.23992391
50MP0008058_abnormal_DNA_repair1.23428529
51MP0002132_abnormal_respiratory_system1.22683666
52MP0003186_abnormal_redox_activity1.21502161
53MP0005025_abnormal_response_to1.18214255
54MP0002452_abnormal_antigen_presenting1.17480547
55MP0002398_abnormal_bone_marrow1.17188585
56MP0003195_calcinosis1.15969893
57MP0000716_abnormal_immune_system1.14605397
58MP0001293_anophthalmia1.14121529
59MP0004145_abnormal_muscle_electrophysio1.10925419
60MP0001968_abnormal_touch/_nociception1.09766387
61MP0002095_abnormal_skin_pigmentation1.07349946
62MP0003878_abnormal_ear_physiology1.07066849
63MP0005377_hearing/vestibular/ear_phenot1.07066849
64MP0000689_abnormal_spleen_morphology1.06171838
65MP0006036_abnormal_mitochondrial_physio1.05429000
66MP0002160_abnormal_reproductive_system1.03397051
67MP0003806_abnormal_nucleotide_metabolis1.02737397
68MP0006276_abnormal_autonomic_nervous1.02691256
69MP0004885_abnormal_endolymph1.01880276
70MP0001919_abnormal_reproductive_system1.01514184
71MP0005410_abnormal_fertilization1.01338566
72MP0002876_abnormal_thyroid_physiology1.00159039
73MP0002736_abnormal_nociception_after0.99106011
74MP0003866_abnormal_defecation0.96173850
75MP0006082_CNS_inflammation0.95228449
76MP0001485_abnormal_pinna_reflex0.94965248
77MP0000703_abnormal_thymus_morphology0.93838578
78MP0002653_abnormal_ependyma_morphology0.93561435
79MP0002722_abnormal_immune_system0.93150609
80MP0002693_abnormal_pancreas_physiology0.93043901
81MP0010155_abnormal_intestine_physiology0.92719318
82MP0003718_maternal_effect0.91866109
83MP0002429_abnormal_blood_cell0.90476913
84MP0005636_abnormal_mineral_homeostasis0.89459040
85MP0002405_respiratory_system_inflammati0.88293625
86MP0001845_abnormal_inflammatory_respons0.83977547
87MP0009764_decreased_sensitivity_to0.81849374
88MP0002234_abnormal_pharynx_morphology0.80742896
89MP0004742_abnormal_vestibular_system0.74727788
90MP0000678_abnormal_parathyroid_gland0.74696871
91MP0003011_delayed_dark_adaptation0.74322722
92MP0008007_abnormal_cellular_replicative0.74011644
93MP0008469_abnormal_protein_level0.73563132
94MP0000631_abnormal_neuroendocrine_gland0.71528263
95MP0001661_extended_life_span0.69894797
96MP0002272_abnormal_nervous_system0.68785483
97MP0005464_abnormal_platelet_physiology0.68692247
98MP0001529_abnormal_vocalization0.68673170
99MP0002938_white_spotting0.68079660
100MP0002019_abnormal_tumor_incidence0.66512776

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.67476941
2Acute necrotizing encephalopathy (HP:0006965)4.66441952
3Increased hepatocellular lipid droplets (HP:0006565)4.61061556
4Lipid accumulation in hepatocytes (HP:0006561)4.16650310
5Increased CSF lactate (HP:0002490)4.14869726
6Abnormal mitochondria in muscle tissue (HP:0008316)4.05711127
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05080855
8Progressive macrocephaly (HP:0004481)3.95841654
9Aplastic anemia (HP:0001915)3.89776135
10Acute encephalopathy (HP:0006846)3.86668532
11Renal Fanconi syndrome (HP:0001994)3.84967684
12Hepatocellular necrosis (HP:0001404)3.74292828
13Hepatic necrosis (HP:0002605)3.44930783
14Increased intramyocellular lipid droplets (HP:0012240)3.43938994
15Abnormal rod and cone electroretinograms (HP:0008323)3.40744314
16Elevated erythrocyte sedimentation rate (HP:0003565)3.35800088
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.33810470
18Cerebral edema (HP:0002181)3.32568097
19Congenital stationary night blindness (HP:0007642)3.32304083
20Exertional dyspnea (HP:0002875)3.28063347
21Pancreatic cysts (HP:0001737)3.11702414
223-Methylglutaconic aciduria (HP:0003535)3.09920117
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97236238
24Abnormality of cells of the erythroid lineage (HP:0012130)2.94170428
25Pancreatic fibrosis (HP:0100732)2.88373091
26Increased serum lactate (HP:0002151)2.88142598
27Abolished electroretinogram (ERG) (HP:0000550)2.85275755
28Increased muscle lipid content (HP:0009058)2.84572162
29IgG deficiency (HP:0004315)2.78781398
30True hermaphroditism (HP:0010459)2.77438114
31Optic disc pallor (HP:0000543)2.74280689
32Reticulocytopenia (HP:0001896)2.62415705
33Lactic acidosis (HP:0003128)2.59973456
34Decreased central vision (HP:0007663)2.58867124
35Reduced antithrombin III activity (HP:0001976)2.56266179
36T lymphocytopenia (HP:0005403)2.53459414
37Abnormality of midbrain morphology (HP:0002418)2.52230506
38Molar tooth sign on MRI (HP:0002419)2.52230506
39Abnormal number of erythroid precursors (HP:0012131)2.52113789
40Macrocytic anemia (HP:0001972)2.51234825
41Methylmalonic acidemia (HP:0002912)2.51036099
42Abnormality of urine glucose concentration (HP:0011016)2.48325836
43Glycosuria (HP:0003076)2.48325836
44Hypoproteinemia (HP:0003075)2.44988678
45Respiratory difficulties (HP:0002880)2.43408280
46Attenuation of retinal blood vessels (HP:0007843)2.42740626
47Abnormality of renal resorption (HP:0011038)2.41641306
48Abnormality of B cell number (HP:0010975)2.40905255
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39737910
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39737910
51B lymphocytopenia (HP:0010976)2.39022837
52Severe combined immunodeficiency (HP:0004430)2.35325461
53Abnormality of T cell number (HP:0011839)2.33538921
54Congenital, generalized hypertrichosis (HP:0004540)2.30202443
55Constricted visual fields (HP:0001133)2.28575538
56Exercise intolerance (HP:0003546)2.28487268
57Respiratory failure (HP:0002878)2.22500001
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21856788
59Hyperglycinemia (HP:0002154)2.21358495
60Lethargy (HP:0001254)2.20193745
61Type 2 muscle fiber atrophy (HP:0003554)2.18281350
62Hyperphosphaturia (HP:0003109)2.14224516
63Type II lissencephaly (HP:0007260)2.09720925
64Asplenia (HP:0001746)2.08085601
65Thyroiditis (HP:0100646)2.07912335
66Pancytopenia (HP:0001876)2.07680759
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.06492008
68Pallor (HP:0000980)2.04580428
69Increased IgM level (HP:0003496)2.04516147
70Pendular nystagmus (HP:0012043)2.02777384
71Nephronophthisis (HP:0000090)2.02615079
72Absent/shortened dynein arms (HP:0200106)2.01797684
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.01797684
74Methylmalonic aciduria (HP:0012120)2.00938639
75Leukodystrophy (HP:0002415)2.00874374
76Stomatitis (HP:0010280)2.00352192
77Muscle fiber atrophy (HP:0100295)1.94572037
78Type I transferrin isoform profile (HP:0003642)1.93829158
79Abnormal protein glycosylation (HP:0012346)1.93010856
80Abnormal glycosylation (HP:0012345)1.93010856
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93010856
82Abnormal protein N-linked glycosylation (HP:0012347)1.93010856
83Ketosis (HP:0001946)1.92438612
84Abnormality of the prostate (HP:0008775)1.91313936
85Generalized aminoaciduria (HP:0002909)1.89284661
86Hypoplasia of the uterus (HP:0000013)1.82421550
87Abnormality of T cells (HP:0002843)1.82072883
88Medial flaring of the eyebrow (HP:0010747)1.81496399
89Aplasia/hypoplasia of the uterus (HP:0008684)1.81330495
90Colon cancer (HP:0003003)1.81279893
91Stenosis of the external auditory canal (HP:0000402)1.79245442
92Sclerocornea (HP:0000647)1.78766833
93Agammaglobulinemia (HP:0004432)1.77385850
94Oral leukoplakia (HP:0002745)1.77380617
95Male pseudohermaphroditism (HP:0000037)1.75710293
96Cystic liver disease (HP:0006706)1.73115314
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72097000
98Dicarboxylic aciduria (HP:0003215)1.72097000
99Renal cortical cysts (HP:0000803)1.71242185
100Abnormal biliary tract physiology (HP:0012439)1.70715986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.65376847
2VRK23.55403961
3TXK3.19474755
4KDR3.02429325
5TESK22.98820210
6BCKDK2.93714221
7ZAK2.84481842
8TAOK32.54926976
9TLK12.51806938
10GRK12.50557683
11ADRBK22.27690440
12NUAK12.19578606
13MAP3K122.18814675
14VRK12.10665025
15MAP4K12.08380574
16MAP4K22.04318403
17STK161.98834208
18SCYL21.95951281
19MST41.80743688
20PBK1.79358937
21FRK1.64541193
22ITK1.46764812
23EIF2AK31.44605594
24TNIK1.42932205
25NLK1.40185897
26BMPR21.31547363
27BUB11.31238935
28PASK1.24176107
29CDC71.23094415
30WNK41.16349496
31GRK61.16272373
32DYRK21.16202103
33NME11.14605280
34TEC1.14207304
35DAPK11.11497136
36TAF11.10923669
37PRKCQ1.02333522
38SYK1.01082334
39BTK1.00489326
40PINK10.94817992
41BMPR1B0.93228071
42MYLK0.87612053
43WNK30.87476512
44CSNK1G10.85618470
45IKBKB0.85405189
46MUSK0.84561357
47LIMK10.84515791
48KIT0.83892175
49PIK3CG0.80468437
50RPS6KA40.78582651
51DAPK30.76744974
52INSRR0.76317227
53OXSR10.72680652
54LCK0.69837974
55TIE10.69613452
56PLK40.67254138
57RPS6KA50.66327741
58LYN0.63727102
59IKBKE0.63463312
60PLK30.61491137
61TNK20.59645472
62MAP3K110.58531599
63DAPK20.58183713
64FES0.58145458
65NME20.57165197
66CSNK2A20.56059359
67EIF2AK10.55551846
68ADRBK10.55352821
69FLT30.54152567
70CSF1R0.53087447
71OBSCN0.52647987
72PRKG20.52419810
73CSNK1G30.51726731
74MAP2K60.50604900
75TRIM280.48219927
76CDK30.46479165
77CSNK2A10.45091566
78MAP2K70.44619902
79AURKB0.42358225
80TESK10.42149899
81PIM10.41461860
82ATR0.41376191
83PLK10.40223695
84MAPKAPK30.37457346
85GRK70.37282473
86CSNK1G20.36923385
87STK390.36866501
88CLK10.36860258
89MKNK10.36237360
90PRKACA0.36087251
91MATK0.35952060
92MAP3K40.35575673
93PRKCA0.33687147
94SRPK10.32819126
95MAP3K50.32457197
96RPS6KB20.31326507
97MAPKAPK50.31156230
98HCK0.30131396
99PRKCG0.30025907
100ERBB30.28383150

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.52168686
2Proteasome_Homo sapiens_hsa030504.22584272
3Oxidative phosphorylation_Homo sapiens_hsa001903.92626329
4Parkinsons disease_Homo sapiens_hsa050123.29350923
5Primary immunodeficiency_Homo sapiens_hsa053402.73682549
6RNA polymerase_Homo sapiens_hsa030202.63095610
7Asthma_Homo sapiens_hsa053102.58972920
8Allograft rejection_Homo sapiens_hsa053302.54997078
9Autoimmune thyroid disease_Homo sapiens_hsa053202.44497390
10Graft-versus-host disease_Homo sapiens_hsa053322.33329536
11Type I diabetes mellitus_Homo sapiens_hsa049402.17991148
12Huntingtons disease_Homo sapiens_hsa050162.17882074
13Alzheimers disease_Homo sapiens_hsa050102.13035782
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.06052024
15Protein export_Homo sapiens_hsa030601.90563984
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87521522
17Antigen processing and presentation_Homo sapiens_hsa046121.85353377
18Cardiac muscle contraction_Homo sapiens_hsa042601.80063549
19Homologous recombination_Homo sapiens_hsa034401.79611760
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75762461
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69827752
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65676690
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63140686
24Phototransduction_Homo sapiens_hsa047441.58520093
25RNA degradation_Homo sapiens_hsa030181.55599748
26Linoleic acid metabolism_Homo sapiens_hsa005911.47738453
27Pyrimidine metabolism_Homo sapiens_hsa002401.39614024
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39204934
29Mismatch repair_Homo sapiens_hsa034301.34310077
30DNA replication_Homo sapiens_hsa030301.28997175
31Hematopoietic cell lineage_Homo sapiens_hsa046401.26450378
32One carbon pool by folate_Homo sapiens_hsa006701.24794049
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24418659
34Rheumatoid arthritis_Homo sapiens_hsa053231.14864698
35Fanconi anemia pathway_Homo sapiens_hsa034601.11450534
36Nucleotide excision repair_Homo sapiens_hsa034201.07538055
37Purine metabolism_Homo sapiens_hsa002301.02970942
38Spliceosome_Homo sapiens_hsa030401.01831000
39Basal transcription factors_Homo sapiens_hsa030221.00740511
40Peroxisome_Homo sapiens_hsa041460.98122139
41RNA transport_Homo sapiens_hsa030130.98047373
42Base excision repair_Homo sapiens_hsa034100.94703056
43Propanoate metabolism_Homo sapiens_hsa006400.94238616
44Butanoate metabolism_Homo sapiens_hsa006500.93396912
45Nitrogen metabolism_Homo sapiens_hsa009100.92374764
46Caffeine metabolism_Homo sapiens_hsa002320.87414796
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.84700581
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83068650
49Arachidonic acid metabolism_Homo sapiens_hsa005900.81563192
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81253435
51Olfactory transduction_Homo sapiens_hsa047400.80781232
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79437010
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76075284
54Viral myocarditis_Homo sapiens_hsa054160.72308736
55Ether lipid metabolism_Homo sapiens_hsa005650.69783613
56Chemical carcinogenesis_Homo sapiens_hsa052040.67381512
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67336810
58T cell receptor signaling pathway_Homo sapiens_hsa046600.63209290
59Sulfur metabolism_Homo sapiens_hsa009200.62878459
60Retinol metabolism_Homo sapiens_hsa008300.62520200
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.62290536
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61647394
63Metabolic pathways_Homo sapiens_hsa011000.60776171
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60191813
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59184851
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.58524567
67Systemic lupus erythematosus_Homo sapiens_hsa053220.57403682
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57357098
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55887198
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54205281
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53847798
72Fat digestion and absorption_Homo sapiens_hsa049750.49891527
73Collecting duct acid secretion_Homo sapiens_hsa049660.46910584
74Staphylococcus aureus infection_Homo sapiens_hsa051500.46058655
75Glutathione metabolism_Homo sapiens_hsa004800.45142399
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.43417567
77Taste transduction_Homo sapiens_hsa047420.42828406
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42551132
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42426215
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41637346
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.41602028
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40947179
83Epstein-Barr virus infection_Homo sapiens_hsa051690.36717522
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.36263702
85Fatty acid elongation_Homo sapiens_hsa000620.35762943
86Tryptophan metabolism_Homo sapiens_hsa003800.35530999
87Regulation of autophagy_Homo sapiens_hsa041400.35105052
88Herpes simplex infection_Homo sapiens_hsa051680.34792950
89Non-homologous end-joining_Homo sapiens_hsa034500.34410597
90Folate biosynthesis_Homo sapiens_hsa007900.33962626
91Measles_Homo sapiens_hsa051620.30913529
92Leishmaniasis_Homo sapiens_hsa051400.25880145
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23443312
94Nicotine addiction_Homo sapiens_hsa050330.23153102
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23118374
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20406644
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17298642
98Ovarian steroidogenesis_Homo sapiens_hsa049130.14884493
99Salivary secretion_Homo sapiens_hsa049700.14548400
100Selenocompound metabolism_Homo sapiens_hsa004500.13776869

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