ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.08554504
2	viral transcription (GO:0019083)	7.29796994
3	ribosomal small subunit biogenesis (GO:0042274)	7.13674973
4	translational termination (GO:0006415)	7.00557652
5	translational elongation (GO:0006414)	6.25093735
6	maturation of SSU-rRNA (GO:0030490)	6.24540276
7	DNA deamination (GO:0045006)	6.16148614
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.13593171
9	cotranslational protein targeting to membrane (GO:0006613)	6.05814983
10	protein targeting to ER (GO:0045047)	6.01478929
11	ATP synthesis coupled proton transport (GO:0015986)	5.78037441
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.78037441
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.74819988
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.74663242
15	protein localization to endoplasmic reticulum (GO:0070972)	5.68095555
16	chaperone-mediated protein transport (GO:0072321)	5.51369559
17	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.50258503
18	cellular protein complex disassembly (GO:0043624)	5.30426106
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.18803748
20	viral life cycle (GO:0019058)	5.15990219
21	cytidine deamination (GO:0009972)	5.12847776
22	cytidine metabolic process (GO:0046087)	5.12847776
23	cytidine catabolic process (GO:0006216)	5.12847776
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.05189884
25	translational initiation (GO:0006413)	4.99728571
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.71165167
27	translation (GO:0006412)	4.42790788
28	respiratory electron transport chain (GO:0022904)	4.38107976
29	protein complex disassembly (GO:0043241)	4.36895841
30	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.35785391
31	electron transport chain (GO:0022900)	4.33257356
32	protein complex biogenesis (GO:0070271)	4.25736032
33	protein neddylation (GO:0045116)	4.15500661
34	macromolecular complex disassembly (GO:0032984)	4.13047675
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.11417051
36	NADH dehydrogenase complex assembly (GO:0010257)	4.11417051
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.11417051
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.98054908
39	ribosomal large subunit biogenesis (GO:0042273)	3.96519582
40	protein targeting to membrane (GO:0006612)	3.95498511
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.77451034
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.74612948
43	cellular component biogenesis (GO:0044085)	3.68274888
44	GTP biosynthetic process (GO:0006183)	3.63009224
45	mRNA catabolic process (GO:0006402)	3.51394572
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.48834682
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.45366575
48	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.41113100
49	ATP biosynthetic process (GO:0006754)	3.39795212
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.37983253
51	UTP biosynthetic process (GO:0006228)	3.35595826
52	pseudouridine synthesis (GO:0001522)	3.26053379
53	proteasome assembly (GO:0043248)	3.22161497
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.21245437
55	termination of RNA polymerase III transcription (GO:0006386)	3.21245437
56	RNA catabolic process (GO:0006401)	3.20887635
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.17077686
58	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.15413611
59	ncRNA 3-end processing (GO:0043628)	3.13659121
60	UTP metabolic process (GO:0046051)	3.09196444
61	respiratory chain complex IV assembly (GO:0008535)	3.04851160
62	rRNA processing (GO:0006364)	3.01352130
63	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.00603885
64	response to pheromone (GO:0019236)	2.99629707
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98907813
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97555573
67	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97555573
68	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.97477920
69	hydrogen ion transmembrane transport (GO:1902600)	2.97150160
70	iron-sulfur cluster assembly (GO:0016226)	2.96436528
71	metallo-sulfur cluster assembly (GO:0031163)	2.96436528
72	rRNA metabolic process (GO:0016072)	2.96186014
73	behavioral response to nicotine (GO:0035095)	2.95808573
74	guanosine-containing compound biosynthetic process (GO:1901070)	2.94944865
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.93071869
76	cytochrome complex assembly (GO:0017004)	2.91281051
77	positive regulation of T cell apoptotic process (GO:0070234)	2.90151316
78	CTP metabolic process (GO:0046036)	2.79077007
79	CTP biosynthetic process (GO:0006241)	2.79077007
80	protein targeting to mitochondrion (GO:0006626)	2.78025567
81	protein-cofactor linkage (GO:0018065)	2.77042060
82	positive regulation of prostaglandin secretion (GO:0032308)	2.76946370
83	pyrimidine nucleotide catabolic process (GO:0006244)	2.74569858
84	sequestering of actin monomers (GO:0042989)	2.73838952
85	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.73490529
86	nucleoside triphosphate biosynthetic process (GO:0009142)	2.72755533
87	proton transport (GO:0015992)	2.69391497
88	establishment of protein localization to membrane (GO:0090150)	2.65197605
89	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.63941343
90	formation of translation preinitiation complex (GO:0001731)	2.63616902
91	intracellular protein transmembrane import (GO:0044743)	2.63066371
92	establishment of protein localization to mitochondrion (GO:0072655)	2.62541135
93	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.62489137
94	hydrogen transport (GO:0006818)	2.61918660
95	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.61605285
96	protein peptidyl-prolyl isomerization (GO:0000413)	2.60715956
97	protein targeting (GO:0006605)	2.60156244
98	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.57714635
99	ribosome biogenesis (GO:0042254)	2.57343536
100	rRNA modification (GO:0000154)	2.56746007

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23541419
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.00546869
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.99345726
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.53886524
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.29904318
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.22287175
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.21061738
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.20282964
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06687456
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.99193185
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.75563857
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.59600190
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55225295
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.54668528
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.40265151
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.34874385
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.32356708
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30750121
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.27543686
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.26652803
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24900634
22	VDR_22108803_ChIP-Seq_LS180_Human	2.11857779
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.11835747
24	MYC_18940864_ChIP-ChIP_HL60_Human	2.11135248
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.06235606
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.96778514
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.93955370
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.82057391
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74562023
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70275185
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70179911
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69468817
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.68590326
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.66948818
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64925831
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.63205530
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.59684466
38	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.57031146
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53435551
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.46146831
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.45734583
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44139492
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.41323527
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.37231094
45	EWS_26573619_Chip-Seq_HEK293_Human	1.35667713
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.29430480
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.28626818
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.27119742
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23013832
50	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20685068
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19656884
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19567444
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19365789
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19300539
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19281589
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16042310
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14239746
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12496309
59	AR_20517297_ChIP-Seq_VCAP_Human	1.08688619
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08555512
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.08379052
62	NCOR_22424771_ChIP-Seq_293T_Human	1.07559532
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07294203
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07131298
65	FUS_26573619_Chip-Seq_HEK293_Human	1.06950096
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05924239
67	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05814985
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05088028
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.04973778
70	E2F7_22180533_ChIP-Seq_HELA_Human	1.04546093
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03837221
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03837221
73	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02927104
74	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02692644
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02534337
76	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02443500
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02026041
78	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.00359768
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99726421
80	ERG_20517297_ChIP-Seq_VCAP_Human	0.98451683
81	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96385779
82	BCL6_27268052_Chip-Seq_Bcells_Human	0.96034510
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96003103
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95508744
85	ERA_21632823_ChIP-Seq_H3396_Human	0.95479796
86	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94413356
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93530412
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93505049
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89841686
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87385365
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87385365
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86307797
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.85850605
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85259575
95	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.83247801
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82327439
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82142814
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.81704341
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80940710
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80538039

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.29787542
2	MP0006292_abnormal_olfactory_placode	4.49825067
3	MP0003878_abnormal_ear_physiology	2.71604471
4	MP0005377_hearing/vestibular/ear_phenot	2.71604471
5	MP0005671_abnormal_response_to	2.61550031
6	MP0001348_abnormal_lacrimal_gland	2.59882272
7	MP0008877_abnormal_DNA_methylation	2.44450224
8	MP0002102_abnormal_ear_morphology	2.06498891
9	MP0005379_endocrine/exocrine_gland_phen	1.96640782
10	MP0002138_abnormal_hepatobiliary_system	1.89097355
11	MP0001485_abnormal_pinna_reflex	1.80077966
12	MP0002277_abnormal_respiratory_mucosa	1.76950429
13	MP0002837_dystrophic_cardiac_calcinosis	1.74556083
14	MP0001188_hyperpigmentation	1.74387511
15	MP0002163_abnormal_gland_morphology	1.73252381
16	MP0001293_anophthalmia	1.70011679
17	MP0008872_abnormal_physiological_respon	1.68363772
18	MP0002653_abnormal_ependyma_morphology	1.67527975
19	MP0001905_abnormal_dopamine_level	1.66653475
20	MP0003283_abnormal_digestive_organ	1.63805016
21	MP0005084_abnormal_gallbladder_morpholo	1.59585915
22	MP0004147_increased_porphyrin_level	1.57860954
23	MP0005551_abnormal_eye_electrophysiolog	1.56364395
24	MP0005174_abnormal_tail_pigmentation	1.53172664
25	MP0004885_abnormal_endolymph	1.50851185
26	MP0003786_premature_aging	1.48371043
27	MP0009333_abnormal_splenocyte_physiolog	1.43841658
28	MP0003123_paternal_imprinting	1.41083204
29	MP0000049_abnormal_middle_ear	1.40557672
30	MP0003646_muscle_fatigue	1.36790879
31	MP0004742_abnormal_vestibular_system	1.35280325
32	MP0002876_abnormal_thyroid_physiology	1.34809156
33	MP0008875_abnormal_xenobiotic_pharmacok	1.30412918
34	MP0008995_early_reproductive_senescence	1.30283406
35	MP0002095_abnormal_skin_pigmentation	1.29244680
36	MP0002234_abnormal_pharynx_morphology	1.27334487
37	MP0000566_synostosis	1.27188850
38	MP0005645_abnormal_hypothalamus_physiol	1.26390722
39	MP0005075_abnormal_melanosome_morpholog	1.24922894
40	MP0005389_reproductive_system_phenotype	1.23118597
41	MP0005646_abnormal_pituitary_gland	1.23087261
42	MP0001873_stomach_inflammation	1.21886747
43	MP0004142_abnormal_muscle_tone	1.21541931
44	MP0006276_abnormal_autonomic_nervous	1.19397933
45	MP0003567_abnormal_fetal_cardiomyocyte	1.16940941
46	MP0002638_abnormal_pupillary_reflex	1.14640262
47	MP0008789_abnormal_olfactory_epithelium	1.12324427
48	MP0002160_abnormal_reproductive_system	1.11817402
49	MP0001986_abnormal_taste_sensitivity	1.11607786
50	MP0001764_abnormal_homeostasis	1.10910631
51	MP0006036_abnormal_mitochondrial_physio	1.10503271
52	MP0009785_altered_susceptibility_to	1.10449625
53	MP0003122_maternal_imprinting	1.10408691
54	MP0003763_abnormal_thymus_physiology	1.09738093
55	MP0001529_abnormal_vocalization	1.09575465
56	MP0004145_abnormal_muscle_electrophysio	1.09402003
57	MP0001919_abnormal_reproductive_system	1.08621970
58	MP0002938_white_spotting	1.06053161
59	MP0000631_abnormal_neuroendocrine_gland	1.05834068
60	MP0000678_abnormal_parathyroid_gland	1.03809482
61	MP0008058_abnormal_DNA_repair	1.03691635
62	MP0000372_irregular_coat_pigmentation	1.02003618
63	MP0001968_abnormal_touch/_nociception	1.01237536
64	MP0002736_abnormal_nociception_after	1.00396703
65	MP0006072_abnormal_retinal_apoptosis	0.99834829
66	MP0003866_abnormal_defecation	0.98471580
67	MP0002272_abnormal_nervous_system	0.91156366
68	MP0001800_abnormal_humoral_immune	0.89242075
69	MP0000026_abnormal_inner_ear	0.88160577
70	MP0003186_abnormal_redox_activity	0.87885510
71	MP0000685_abnormal_immune_system	0.86678741
72	MP0003938_abnormal_ear_development	0.86311408
73	MP0002210_abnormal_sex_determination	0.85957405
74	MP0001790_abnormal_immune_system	0.82321842
75	MP0005387_immune_system_phenotype	0.82321842
76	MP0002148_abnormal_hypersensitivity_rea	0.80552223
77	MP0003693_abnormal_embryo_hatching	0.79480395
78	MP0001963_abnormal_hearing_physiology	0.78889196
79	MP0003195_calcinosis	0.78625805
80	MP0010030_abnormal_orbit_morphology	0.78234836
81	MP0005253_abnormal_eye_physiology	0.77452999
82	MP0003011_delayed_dark_adaptation	0.76986135
83	MP0002723_abnormal_immune_serum	0.76155332
84	MP0001984_abnormal_olfaction	0.75864358
85	MP0003936_abnormal_reproductive_system	0.74179297
86	MP0005195_abnormal_posterior_eye	0.73960877
87	MP0001835_abnormal_antigen_presentation	0.73831516
88	MP0003718_maternal_effect	0.73106953
89	MP0001727_abnormal_embryo_implantation	0.72433410
90	MP0005332_abnormal_amino_acid	0.72241225
91	MP0001661_extended_life_span	0.72209135
92	MP0001502_abnormal_circadian_rhythm	0.71818022
93	MP0002420_abnormal_adaptive_immunity	0.70366227
94	MP0002132_abnormal_respiratory_system	0.68736961
95	MP0001929_abnormal_gametogenesis	0.67967831
96	MP0009745_abnormal_behavioral_response	0.67793092
97	MP0002184_abnormal_innervation	0.67051961
98	MP0004133_heterotaxia	0.66872044
99	MP0002557_abnormal_social/conspecific_i	0.66515407
100	MP0002733_abnormal_thermal_nociception	0.65910761

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.19160242
2	Acute necrotizing encephalopathy (HP:0006965)	5.17539220
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.77393146
4	Mitochondrial inheritance (HP:0001427)	4.64180848
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.50002263
6	Progressive macrocephaly (HP:0004481)	4.21390769
7	Acute encephalopathy (HP:0006846)	4.20546087
8	Increased CSF lactate (HP:0002490)	4.10114011
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.79480322
10	Cerebral edema (HP:0002181)	3.77303042
11	Hepatocellular necrosis (HP:0001404)	3.65606410
12	Macrocytic anemia (HP:0001972)	3.64656348
13	Increased hepatocellular lipid droplets (HP:0006565)	3.61347359
14	Renal Fanconi syndrome (HP:0001994)	3.49723593
15	Hepatic necrosis (HP:0002605)	3.40671011
16	Abnormality of midbrain morphology (HP:0002418)	3.40468502
17	Molar tooth sign on MRI (HP:0002419)	3.40468502
18	Pancreatic fibrosis (HP:0100732)	3.25330085
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.24875253
20	Lipid accumulation in hepatocytes (HP:0006561)	3.24179625
21	Pancreatic cysts (HP:0001737)	3.21832287
22	3-Methylglutaconic aciduria (HP:0003535)	3.19287835
23	Abnormal number of erythroid precursors (HP:0012131)	3.17436393
24	Increased intramyocellular lipid droplets (HP:0012240)	3.15747347
25	Optic disc pallor (HP:0000543)	2.98538278
26	Aplastic anemia (HP:0001915)	2.92096578
27	Pallor (HP:0000980)	2.86944757
28	Increased serum lactate (HP:0002151)	2.85284391
29	Abolished electroretinogram (ERG) (HP:0000550)	2.83849122
30	Absent thumb (HP:0009777)	2.79496374
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.76692238
32	Absent/shortened dynein arms (HP:0200106)	2.76692238
33	True hermaphroditism (HP:0010459)	2.75484147
34	Congenital stationary night blindness (HP:0007642)	2.72057459
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.69802784
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.69802784
37	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.68486536
38	Septo-optic dysplasia (HP:0100842)	2.61082424
39	Pendular nystagmus (HP:0012043)	2.60826818
40	Colon cancer (HP:0003003)	2.60627457
41	Increased muscle lipid content (HP:0009058)	2.60379980
42	Lactic acidosis (HP:0003128)	2.52363059
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.47732888
44	Abnormality of DNA repair (HP:0003254)	2.45399428
45	Respiratory failure (HP:0002878)	2.43594590
46	Exertional dyspnea (HP:0002875)	2.40576527
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.39992932
48	Sclerocornea (HP:0000647)	2.38945200
49	Asplenia (HP:0001746)	2.36388295
50	Constricted visual fields (HP:0001133)	2.32845804
51	IgG deficiency (HP:0004315)	2.31656464
52	Attenuation of retinal blood vessels (HP:0007843)	2.30037365
53	Pancytopenia (HP:0001876)	2.28639092
54	Lethargy (HP:0001254)	2.26705281
55	Abnormality of urine glucose concentration (HP:0011016)	2.26371632
56	Glycosuria (HP:0003076)	2.26371632
57	Chronic hepatic failure (HP:0100626)	2.25312059
58	Nephronophthisis (HP:0000090)	2.22098479
59	Abnormal ciliary motility (HP:0012262)	2.20862344
60	Rib fusion (HP:0000902)	2.16296920
61	Exercise intolerance (HP:0003546)	2.15278091
62	Respiratory difficulties (HP:0002880)	2.14927109
63	Elevated erythrocyte sedimentation rate (HP:0003565)	2.14116928
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10445516
65	Stenosis of the external auditory canal (HP:0000402)	2.09911980
66	Increased IgM level (HP:0003496)	2.09643590
67	B lymphocytopenia (HP:0010976)	2.09508415
68	Abnormal respiratory motile cilium physiology (HP:0012261)	2.09124705
69	Abnormality of B cell number (HP:0010975)	2.08796189
70	Abnormality of renal resorption (HP:0011038)	2.05953252
71	Leukodystrophy (HP:0002415)	2.05648948
72	Bile duct proliferation (HP:0001408)	2.02004768
73	Abnormal biliary tract physiology (HP:0012439)	2.02004768
74	Polydipsia (HP:0001959)	1.98825244
75	Abnormal drinking behavior (HP:0030082)	1.98825244
76	Triphalangeal thumb (HP:0001199)	1.98166670
77	Decreased central vision (HP:0007663)	1.93273369
78	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91435681
79	Generalized aminoaciduria (HP:0002909)	1.89370048
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.88010496
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88010496
82	Ketosis (HP:0001946)	1.86927713
83	Cystic liver disease (HP:0006706)	1.86848826
84	Severe combined immunodeficiency (HP:0004430)	1.86019175
85	Hypoplasia of the uterus (HP:0000013)	1.85458433
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.82982502
87	Methylmalonic acidemia (HP:0002912)	1.82662794
88	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.81994423
89	Hyperglycinemia (HP:0002154)	1.81016470
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80915369
91	Hyperphosphaturia (HP:0003109)	1.77772472
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76473261
93	Partial duplication of thumb phalanx (HP:0009944)	1.76463126
94	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.75671389
95	Anencephaly (HP:0002323)	1.74852281
96	Depressed nasal ridge (HP:0000457)	1.74281441
97	Microvesicular hepatic steatosis (HP:0001414)	1.74276470
98	Optic nerve coloboma (HP:0000588)	1.71887418
99	Methylmalonic aciduria (HP:0012120)	1.71045994
100	CNS demyelination (HP:0007305)	1.67474595

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.76554524
2	VRK2	3.46492222
3	KDR	2.98738830
4	GRK1	2.52352072
5	TXK	2.39468538
6	MAP3K11	2.38069206
7	MAP4K2	2.36876494
8	ADRBK2	2.32190007
9	NUAK1	2.31547026
10	PASK	2.22337829
11	STK16	2.06278548
12	NME2	2.00238543
13	CDK19	2.00049546
14	WNK4	1.95294072
15	TESK2	1.89028098
16	MAP3K12	1.83837655
17	ZAK	1.83056079
18	BUB1	1.82721025
19	FRK	1.77312384
20	CDC7	1.77031441
21	MAP4K1	1.76490765
22	VRK1	1.75242877
23	DYRK2	1.67155005
24	ITK	1.58468873
25	TAOK3	1.53107663
26	BMPR1B	1.47412027
27	TAF1	1.45422280
28	PINK1	1.36988744
29	LIMK1	1.34257752
30	PIK3CA	1.32682942
31	NME1	1.31390731
32	PBK	1.30204029
33	MST4	1.29156055
34	WEE1	1.26330567
35	TEC	1.17370032
36	INSRR	1.15697079
37	TLK1	1.08041413
38	WNK3	1.08001534
39	TIE1	1.07163055
40	LRRK2	1.00179460
41	AURKA	0.99706619
42	BRSK2	0.95885094
43	PRKCQ	0.91286091
44	GRK6	0.86617380
45	MAP3K9	0.85838804
46	TNIK	0.83775148
47	DAPK3	0.75992021
48	BTK	0.75654238
49	IKBKB	0.72812282
50	ADRBK1	0.72767022
51	PLK1	0.72462959
52	CSNK2A2	0.70946068
53	RPS6KB2	0.69397088
54	NEK1	0.68406574
55	AURKB	0.68002065
56	ACVR1B	0.67194133
57	CSNK1G3	0.66534395
58	PIK3CG	0.65913185
59	OXSR1	0.65147282
60	TGFBR1	0.64782684
61	STK39	0.63856358
62	CAMK1	0.63037211
63	DAPK1	0.60988373
64	PRKCH	0.60320852
65	ABL2	0.60278391
66	LCK	0.59978541
67	GRK5	0.59825019
68	SYK	0.59786857
69	PLK3	0.58575981
70	CDK8	0.55702132
71	CSNK2A1	0.52845164
72	SRPK1	0.52804662
73	KIT	0.52370766
74	EIF2AK1	0.51999739
75	BRSK1	0.51509951
76	CSNK1G2	0.51449013
77	CHEK2	0.51445925
78	ATR	0.49058271
79	CSNK1G1	0.48922988
80	EIF2AK3	0.48578301
81	PRKACA	0.47800054
82	MAPKAPK5	0.47229741
83	PRKCA	0.44537138
84	PRKCG	0.44127724
85	RPS6KA5	0.42405789
86	BRAF	0.41973202
87	OBSCN	0.40947829
88	MAP2K6	0.40523264
89	PDK2	0.39695662
90	PIM1	0.38691727
91	MAP2K7	0.38689470
92	MUSK	0.38429737
93	RPS6KA6	0.38373297
94	DYRK3	0.34536943
95	PRKCD	0.33560646
96	FES	0.32996674
97	CAMK2A	0.32911281
98	MKNK2	0.32902454
99	MYLK	0.32460934
100	GRK7	0.29864864

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.28290518
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.31633781
3	Parkinsons disease_Homo sapiens_hsa05012	3.70305425
4	Proteasome_Homo sapiens_hsa03050	3.33418897
5	RNA polymerase_Homo sapiens_hsa03020	3.10090483
6	Huntingtons disease_Homo sapiens_hsa05016	2.67242061
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.64990195
8	Alzheimers disease_Homo sapiens_hsa05010	2.49306380
9	Protein export_Homo sapiens_hsa03060	2.33701782
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22317540
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.07461071
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.88681479
13	Homologous recombination_Homo sapiens_hsa03440	1.82010356
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80143827
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74775939
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67339373
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64483079
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63443051
19	DNA replication_Homo sapiens_hsa03030	1.60930599
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52594834
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48589364
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43933429
23	RNA degradation_Homo sapiens_hsa03018	1.41501846
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.39075603
25	Base excision repair_Homo sapiens_hsa03410	1.36159455
26	One carbon pool by folate_Homo sapiens_hsa00670	1.30815736
27	Phototransduction_Homo sapiens_hsa04744	1.30302951
28	Mismatch repair_Homo sapiens_hsa03430	1.26557120
29	Purine metabolism_Homo sapiens_hsa00230	1.23515193
30	Allograft rejection_Homo sapiens_hsa05330	1.08221945
31	Spliceosome_Homo sapiens_hsa03040	1.06810407
32	Sulfur relay system_Homo sapiens_hsa04122	1.05737406
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04827420
34	Propanoate metabolism_Homo sapiens_hsa00640	1.01797405
35	Basal transcription factors_Homo sapiens_hsa03022	1.01475114
36	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.01331911
37	RNA transport_Homo sapiens_hsa03013	1.01248245
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.91036766
39	Peroxisome_Homo sapiens_hsa04146	0.90476733
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89654207
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85193140
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83422898
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.83259741
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83065259
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82198182
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.81000559
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80756260
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.80525412
49	Butanoate metabolism_Homo sapiens_hsa00650	0.80459223
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.79626554
51	Olfactory transduction_Homo sapiens_hsa04740	0.79545497
52	Metabolic pathways_Homo sapiens_hsa01100	0.78114822
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74604432
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74488199
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74371181
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72376198
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.71939254
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69681948
59	Asthma_Homo sapiens_hsa05310	0.69647844
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69635644
61	Folate biosynthesis_Homo sapiens_hsa00790	0.69020611
62	Caffeine metabolism_Homo sapiens_hsa00232	0.65206174
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.64850030
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64531351
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.64474896
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64233210
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.62450940
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61429557
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61375429
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60053160
71	Retinol metabolism_Homo sapiens_hsa00830	0.54636182
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54303648
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52481833
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52093245
75	Glutathione metabolism_Homo sapiens_hsa00480	0.49957590
76	Sulfur metabolism_Homo sapiens_hsa00920	0.47732688
77	Regulation of autophagy_Homo sapiens_hsa04140	0.45166196
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44812549
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.44191433
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39032146
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37445201
82	Nicotine addiction_Homo sapiens_hsa05033	0.35988936
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35958084
84	Fatty acid degradation_Homo sapiens_hsa00071	0.34748146
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32480573
86	Taste transduction_Homo sapiens_hsa04742	0.28637113
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.26781262
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26177585
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24496078
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.24089942
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.21158619
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.18869590
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.18504122
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.18472223
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.18296429
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15459204
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.14622459
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.14612807
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.12373621
100	Morphine addiction_Homo sapiens_hsa05032	0.11593721

RPSAP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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