RPSAP50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)7.07280447
2chaperone-mediated protein transport (GO:0072321)7.04433610
3maturation of SSU-rRNA (GO:0030490)6.49736961
4ribosomal small subunit biogenesis (GO:0042274)5.93839487
5regulation of podosome assembly (GO:0071801)5.77602188
6regulation of immunoglobulin secretion (GO:0051023)5.12680517
7viral transcription (GO:0019083)4.95550030
8positive regulation of chemokine biosynthetic process (GO:0045080)4.86621059
9regulation of fever generation (GO:0031620)4.80061807
10positive regulation of heat generation (GO:0031652)4.77196645
11translational termination (GO:0006415)4.56736594
12neuromuscular process controlling posture (GO:0050884)4.55014321
13regulation of chemokine biosynthetic process (GO:0045073)4.22701437
14regulation of vitamin D biosynthetic process (GO:0060556)4.22278424
15negative regulation of nitric oxide biosynthetic process (GO:0045019)4.17563113
16regulation of isotype switching to IgG isotypes (GO:0048302)4.02164141
17positive regulation of isotype switching (GO:0045830)4.00153248
18muscle organ morphogenesis (GO:0048644)3.93785886
19positive regulation of DNA recombination (GO:0045911)3.93352682
20negative regulation of interleukin-12 production (GO:0032695)3.91654786
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90378456
22ribosomal small subunit assembly (GO:0000028)3.89359396
23protein targeting to ER (GO:0045047)3.88299156
24response to protozoan (GO:0001562)3.83809737
25translational elongation (GO:0006414)3.82599568
26cotranslational protein targeting to membrane (GO:0006613)3.81519020
27proteasome assembly (GO:0043248)3.78731456
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.76116712
29ribosomal large subunit biogenesis (GO:0042273)3.75665992
30positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.75539621
31defense response to protozoan (GO:0042832)3.75095322
32protein localization to endoplasmic reticulum (GO:0070972)3.71151086
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.68415010
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67270178
35viral life cycle (GO:0019058)3.66568897
36cytokine production involved in immune response (GO:0002367)3.50660601
37regulation of heat generation (GO:0031650)3.50020780
38regulation of T-helper 1 cell differentiation (GO:0045625)3.47513686
39prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.40829545
40positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.38563510
41cellular protein complex disassembly (GO:0043624)3.34369266
42hydrogen peroxide biosynthetic process (GO:0050665)3.30110477
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27404741
44regulation of vitamin metabolic process (GO:0030656)3.25468895
45response to peptidoglycan (GO:0032494)3.25329308
46negative regulation of mast cell activation (GO:0033004)3.24519545
47ear development (GO:0043583)3.19969396
48monocyte chemotaxis (GO:0002548)3.19276196
49regulation of inflammatory response to antigenic stimulus (GO:0002861)3.14317994
50regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.13909672
51positive regulation of B cell mediated immunity (GO:0002714)3.13048044
52positive regulation of immunoglobulin mediated immune response (GO:0002891)3.13048044
53regulation of membrane protein ectodomain proteolysis (GO:0051043)3.10214950
54regulation of cytokine secretion involved in immune response (GO:0002739)3.08826157
55regulation of isotype switching (GO:0045191)3.08396051
56termination of RNA polymerase III transcription (GO:0006386)3.07777751
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.07777751
58regulation of mononuclear cell migration (GO:0071675)3.04054956
59protein targeting to mitochondrion (GO:0006626)3.03916737
60translational initiation (GO:0006413)3.03152970
61purine nucleotide salvage (GO:0032261)3.02662329
62reactive oxygen species biosynthetic process (GO:1903409)2.92684996
63production of molecular mediator of immune response (GO:0002440)2.88124940
64positive regulation of immunoglobulin production (GO:0002639)2.88072627
65oligosaccharide catabolic process (GO:0009313)2.87423289
66regulation of MHC class II biosynthetic process (GO:0045346)2.82015845
67cellular response to nicotine (GO:0071316)2.81967414
68negative regulation of monooxygenase activity (GO:0032769)2.80561408
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80206935
70regulation of immunoglobulin production (GO:0002637)2.79701380
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79455593
72negative regulation of T-helper cell differentiation (GO:0045623)2.79455593
73iron-sulfur cluster assembly (GO:0016226)2.78120728
74metallo-sulfur cluster assembly (GO:0031163)2.78120728
752-deoxyribonucleotide biosynthetic process (GO:0009265)2.76437873
76deoxyribose phosphate biosynthetic process (GO:0046385)2.76437873
77branching involved in labyrinthine layer morphogenesis (GO:0060670)2.75714002
78negative regulation of cytokine production involved in immune response (GO:0002719)2.75152080
79positive regulation of lymphocyte apoptotic process (GO:0070230)2.72469775
80protein deneddylation (GO:0000338)2.72346148
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.71525660
82NADH dehydrogenase complex assembly (GO:0010257)2.71525660
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71525660
84regulation of T-helper cell differentiation (GO:0045622)2.69265391
85negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)2.66777048
86positive regulation of prostaglandin secretion (GO:0032308)2.66657481
87macrophage chemotaxis (GO:0048246)2.64116864
88translation (GO:0006412)2.63897587
89establishment of protein localization to mitochondrion (GO:0072655)2.63509634
90NIK/NF-kappaB signaling (GO:0038061)2.61916857
91protein complex disassembly (GO:0043241)2.61273632
92protein localization to mitochondrion (GO:0070585)2.61220977
93paraxial mesoderm development (GO:0048339)2.59461829
94negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.58661970
95ribonucleoprotein complex biogenesis (GO:0022613)2.57830883
96protein targeting to membrane (GO:0006612)2.57795224
97polarized epithelial cell differentiation (GO:0030859)2.56362887
98cullin deneddylation (GO:0010388)2.55461403
99regulation of interferon-alpha production (GO:0032647)2.51789552
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51689600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.44911343
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.22787745
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.95682797
4SRY_22984422_ChIP-ChIP_TESTIS_Rat3.43091406
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92003341
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.81571464
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.69582205
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69337228
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42461620
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39908673
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39375222
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.32258652
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.32112255
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.30812889
15VDR_21846776_ChIP-Seq_THP-1_Human2.29218040
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.28135268
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23438290
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08752876
19ZNF263_19887448_ChIP-Seq_K562_Human2.00517033
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.98426466
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.96835768
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96428476
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93320182
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90540055
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.86712618
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86358120
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86334026
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83829961
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82127686
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74125912
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71046799
32DCP1A_22483619_ChIP-Seq_HELA_Human1.68086977
33ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63500949
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61618449
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58639880
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57833050
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53574889
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53353051
39VDR_24763502_ChIP-Seq_THP-1_Human1.51233784
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49291013
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46789781
42IRF1_19129219_ChIP-ChIP_H3396_Human1.44411357
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43557845
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42950886
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42016420
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41064518
47VDR_24787735_ChIP-Seq_THP-1_Human1.39961882
48STAT1_20625510_ChIP-Seq_HELA_Human1.39316223
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35984563
50XRN2_22483619_ChIP-Seq_HELA_Human1.33337919
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32846402
52SPI1_23547873_ChIP-Seq_NB4_Human1.31172768
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29872007
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27797323
55TTF2_22483619_ChIP-Seq_HELA_Human1.26148104
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24157485
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23387054
58IGF1R_20145208_ChIP-Seq_DFB_Human1.22107809
59VDR_23849224_ChIP-Seq_CD4+_Human1.19582522
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19336187
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17525998
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15414902
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13954802
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12333171
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11859909
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11851228
67BCOR_27268052_Chip-Seq_Bcells_Human1.11777638
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11720640
69FOXP3_21729870_ChIP-Seq_TREG_Human1.10522633
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.10401587
71SA1_27219007_Chip-Seq_Bcells_Human1.10141442
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08246601
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08246601
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08246601
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06286120
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05704376
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.04690741
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.04370398
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03370367
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03001553
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02998249
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98673473
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98502074
84BCL6_27268052_Chip-Seq_Bcells_Human0.97173949
85LXR_22292898_ChIP-Seq_THP-1_Human0.97115845
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95655934
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95644440
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95308372
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93974139
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91601104
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90830945
92EZH2_22144423_ChIP-Seq_EOC_Human0.90366797
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89965896
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88393379
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88329688
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87823787
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87185690
98LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87126658
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85653827
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.85079139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.86014563
2MP0003941_abnormal_skin_development4.20301673
3MP0006082_CNS_inflammation3.61574918
4MP0002148_abnormal_hypersensitivity_rea3.57859625
5MP0005671_abnormal_response_to3.22314673
6MP0009785_altered_susceptibility_to2.66847172
7MP0001835_abnormal_antigen_presentation2.55674827
8MP0003436_decreased_susceptibility_to2.53520618
9MP0003724_increased_susceptibility_to2.49264522
10MP0000343_altered_response_to2.41811876
11MP0005000_abnormal_immune_tolerance2.40430322
12MP0001790_abnormal_immune_system2.40330388
13MP0005387_immune_system_phenotype2.40330388
14MP0005058_abnormal_lysosome_morphology2.38004307
15MP0009840_abnormal_foam_cell2.32955729
16MP0009764_decreased_sensitivity_to2.14997041
17MP0004510_myositis2.07853687
18MP0002139_abnormal_hepatobiliary_system2.05447570
19MP0005310_abnormal_salivary_gland2.03839965
20MP0009333_abnormal_splenocyte_physiolog2.02209630
21MP0009278_abnormal_bone_marrow1.99598000
22MP0009053_abnormal_anal_canal1.99332744
23MP0005025_abnormal_response_to1.94433805
24MP0003172_abnormal_lysosome_physiology1.87797279
25MP0002452_abnormal_antigen_presenting1.87576526
26MP0005167_abnormal_blood-brain_barrier1.87368927
27MP0001873_stomach_inflammation1.87133210
28MP0002419_abnormal_innate_immunity1.85582830
29MP0001800_abnormal_humoral_immune1.82578582
30MP0002723_abnormal_immune_serum1.74859937
31MP0003186_abnormal_redox_activity1.72283172
32MP0003806_abnormal_nucleotide_metabolis1.67418103
33MP0009379_abnormal_foot_pigmentation1.56543265
34MP0003195_calcinosis1.56116913
35MP0008004_abnormal_stomach_pH1.53971639
36MP0009697_abnormal_copulation1.53514034
37MP0001663_abnormal_digestive_system1.49463037
38MP0001533_abnormal_skeleton_physiology1.48977470
39MP0001819_abnormal_immune_cell1.48208071
40MP0002420_abnormal_adaptive_immunity1.47690129
41MP0001853_heart_inflammation1.44639812
42MP0001845_abnormal_inflammatory_respons1.44536521
43MP0002277_abnormal_respiratory_mucosa1.40707332
44MP0002822_catalepsy1.39680381
45MP0008469_abnormal_protein_level1.35562903
46MP0003183_abnormal_peptide_metabolism1.32471179
47MP0009765_abnormal_xenobiotic_induced1.30195911
48MP0010155_abnormal_intestine_physiology1.27122186
49MP0002998_abnormal_bone_remodeling1.20168719
50MP0002837_dystrophic_cardiac_calcinosis1.16388979
51MP0005397_hematopoietic_system_phenotyp1.14692545
52MP0001545_abnormal_hematopoietic_system1.14692545
53MP0002332_abnormal_exercise_endurance1.13422577
54MP0000685_abnormal_immune_system1.11185016
55MP0002163_abnormal_gland_morphology1.10562866
56MP0003075_altered_response_to1.08775116
57MP0003300_gastrointestinal_ulcer1.05697382
58MP0010307_abnormal_tumor_latency1.05346967
59MP0004858_abnormal_nervous_system1.03244767
60MP0005381_digestive/alimentary_phenotyp1.02302320
61MP0002405_respiratory_system_inflammati1.01666947
62MP0005647_abnormal_sex_gland1.01574516
63MP0000716_abnormal_immune_system1.01246310
64MP0009763_increased_sensitivity_to1.00997225
65MP0005166_decreased_susceptibility_to1.00265526
66MP0003123_paternal_imprinting1.00010939
67MP0005464_abnormal_platelet_physiology0.98682671
68MP0005451_abnormal_body_composition0.98550050
69MP0008875_abnormal_xenobiotic_pharmacok0.98138999
70MP0001727_abnormal_embryo_implantation0.95755848
71MP0006054_spinal_hemorrhage0.94904493
72MP0002653_abnormal_ependyma_morphology0.90388096
73MP0003448_altered_tumor_morphology0.90349040
74MP0005084_abnormal_gallbladder_morpholo0.89938952
75MP0000681_abnormal_thyroid_gland0.87162824
76MP0000858_altered_metastatic_potential0.86836874
77MP0000604_amyloidosis0.86711202
78MP0005410_abnormal_fertilization0.84600278
79MP0004947_skin_inflammation0.82846366
80MP0003453_abnormal_keratinocyte_physiol0.80534265
81MP0002398_abnormal_bone_marrow0.79902413
82MP0002429_abnormal_blood_cell0.77682769
83MP0006292_abnormal_olfactory_placode0.76018675
84MP0005257_abnormal_intraocular_pressure0.72786155
85MP0005187_abnormal_penis_morphology0.72481668
86MP0001270_distended_abdomen0.72476880
87MP0001348_abnormal_lacrimal_gland0.71949336
88MP0006036_abnormal_mitochondrial_physio0.68495819
89MP0000733_abnormal_muscle_development0.68098956
90MP0000767_abnormal_smooth_muscle0.66689444
91MP0003283_abnormal_digestive_organ0.66340492
92MP0003111_abnormal_nucleus_morphology0.65297164
93MP0008872_abnormal_physiological_respon0.62060045
94MP0003633_abnormal_nervous_system0.61532824
95MP0008873_increased_physiological_sensi0.59365695
96MP0000689_abnormal_spleen_morphology0.58502776
97MP0004808_abnormal_hematopoietic_stem0.58491334
98MP0002735_abnormal_chemical_nociception0.57268134
99MP0002177_abnormal_outer_ear0.56675806
100MP0002933_joint_inflammation0.56662914

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the middle phalanges of the toes (HP:0010183)5.35049325
2Abnormality of the phalanges of the hallux (HP:0010057)5.19730528
3Abnormality of glycolipid metabolism (HP:0010969)5.02123404
4Abnormality of liposaccharide metabolism (HP:0010968)5.02123404
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.02123404
6Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.84840226
7Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.40266201
8Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.31377970
9Broad distal phalanx of finger (HP:0009836)4.08782360
10Short middle phalanx of the 5th finger (HP:0004220)4.06084543
11Abnormality of the phalanges of the 2nd finger (HP:0009541)3.99311178
12Abnormality of the phalanges of the 5th finger (HP:0004213)3.96990395
13Rectal prolapse (HP:0002035)3.75972264
14Symphalangism affecting the phalanges of the hand (HP:0009773)3.65891131
15Enlarged epiphyses (HP:0010580)3.30415331
16Hypoplasia of the radius (HP:0002984)3.24160188
17Abnormality of the proximal phalanges of the hand (HP:0009834)3.11102380
18Adactyly (HP:0009776)3.09610454
19Radial bowing (HP:0002986)3.02566160
20Abnormality of the fetal cardiovascular system (HP:0010948)3.00219617
21Abnormal umbilical cord blood vessels (HP:0011403)3.00219617
22Single umbilical artery (HP:0001195)3.00219617
23Vacuolated lymphocytes (HP:0001922)2.94266692
24Progressive microcephaly (HP:0000253)2.79855150
25Cleft eyelid (HP:0000625)2.79598432
263-Methylglutaconic aciduria (HP:0003535)2.78851968
27Neoplasm of head and neck (HP:0012288)2.77533752
28Esophageal neoplasm (HP:0100751)2.77533752
29Esophageal atresia (HP:0002032)2.77248820
30Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.76760694
31Short 1st metacarpal (HP:0010034)2.76760694
32Petechiae (HP:0000967)2.73164750
33Fibular aplasia (HP:0002990)2.72136261
34Increased cerebral lipofuscin (HP:0011813)2.66693031
35Hyperglycinemia (HP:0002154)2.64916067
36Stomatitis (HP:0010280)2.64214911
37Systemic lupus erythematosus (HP:0002725)2.61318885
38Abnormality of macrophages (HP:0004311)2.61256442
39Dysostosis multiplex (HP:0000943)2.57869071
40Acute necrotizing encephalopathy (HP:0006965)2.56378926
41Degeneration of anterior horn cells (HP:0002398)2.55715264
42Abnormality of the anterior horn cell (HP:0006802)2.55715264
43Abnormality of the 4th metacarpal (HP:0010012)2.55429261
44Type II lissencephaly (HP:0007260)2.53090204
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49363841
46Synostosis involving the elbow (HP:0003938)2.47576527
47Humeroradial synostosis (HP:0003041)2.47576527
48Abnormality of the distal phalanges of the toes (HP:0010182)2.47440104
49Nausea (HP:0002018)2.45053007
50Abnormality of the 1st metacarpal (HP:0010009)2.42969366
51Aplastic anemia (HP:0001915)2.41117802
52Partial duplication of the phalanx of hand (HP:0009999)2.37916489
53Hematochezia (HP:0002573)2.37825422
54Purpura (HP:0000979)2.37812664
55Carpal synostosis (HP:0009702)2.37517228
56Optic neuritis (HP:0100653)2.37388685
57Retrobulbar optic neuritis (HP:0100654)2.37388685
58Forearm undergrowth (HP:0009821)2.33035939
59Macrocytic anemia (HP:0001972)2.31118000
60Ureteral stenosis (HP:0000071)2.26869948
61Absent phalangeal crease (HP:0006109)2.25803265
62Abnormality of the 2nd finger (HP:0004100)2.19409120
63Hepatosplenomegaly (HP:0001433)2.19395057
64Abnormal mitochondria in muscle tissue (HP:0008316)2.18004872
65Orchitis (HP:0100796)2.17700123
66Short 5th finger (HP:0009237)2.17400725
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.15280604
68Myositis (HP:0100614)2.15096181
69Mediastinal lymphadenopathy (HP:0100721)2.12176569
70Poor head control (HP:0002421)2.12110399
71Short thumb (HP:0009778)2.10095953
72Parakeratosis (HP:0001036)2.08528714
73Mitochondrial inheritance (HP:0001427)2.07743353
74Recurrent bacterial skin infections (HP:0005406)2.07478181
75Acute encephalopathy (HP:0006846)2.06729076
76Loss of speech (HP:0002371)2.06674024
77Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.05910827
78Colon cancer (HP:0003003)2.05720137
79Synostosis involving bones of the hand (HP:0004278)2.04264674
80Bowing of the arm (HP:0006488)2.03977340
81Bowed forearm bones (HP:0003956)2.03977340
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02416967
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02416967
84Autoimmune thrombocytopenia (HP:0001973)2.00114655
85Progressive macrocephaly (HP:0004481)1.96943224
86Ureteral obstruction (HP:0006000)1.96533314
87Mutism (HP:0002300)1.94361167
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.93936117
89Disinhibition (HP:0000734)1.92250026
90Increased CSF lactate (HP:0002490)1.91301475
91Recurrent abscess formation (HP:0002722)1.88856051
92Transposition of the great arteries (HP:0001669)1.88552813
93Abnormal connection of the cardiac segments (HP:0011545)1.88552813
94Abnormal ventriculo-arterial connection (HP:0011563)1.88552813
95Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.86821988
96Abnormal finger flexion creases (HP:0006143)1.86235871
97Porencephaly (HP:0002132)1.82947006
98Autoimmune hemolytic anemia (HP:0001890)1.82835613
99Increased serum ferritin (HP:0003281)1.81878127
100Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81415845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.95749278
2IRAK35.36849041
3TLK13.12103149
4DDR23.10799898
5IRAK42.92065038
6BUB12.86808654
7ADRBK22.75894529
8MATK2.65589749
9TAOK22.62302943
10GRK72.60340264
11SIK22.55185868
12FGR2.47670844
13IRAK22.31222346
14PBK2.29046367
15SIK32.15722981
16PIM22.02617080
17NEK11.83545116
18MARK31.76321533
19BMPR21.71331383
20IKBKB1.66087404
21ABL21.61317926
22PDK21.42506080
23TXK1.38399049
24PLK41.35764866
25TBK11.31091932
26CCNB11.29630641
27CDK191.29328331
28BLK1.27903423
29TYRO31.26980587
30ACVR1B1.25670694
31PRPF4B1.24939487
32MAP3K141.07781139
33CDC71.05616299
34CSK1.04458767
35RIPK41.01406706
36PTK2B0.98929370
37IRAK10.97736366
38MAP3K30.95484775
39STK240.87111482
40MAP2K30.87041671
41LRRK20.83813585
42SRPK10.83003695
43IKBKE0.81595125
44MAP3K110.80667565
45PIM10.79778458
46TAOK10.78328640
47CDC42BPA0.77835394
48SIK10.74505857
49CAMK1G0.73598675
50TYK20.68445778
51NME10.66941220
52LYN0.65697205
53CASK0.65036128
54STK100.64910338
55RPS6KA50.64545388
56DAPK20.64183982
57MAP4K10.62456312
58CSNK1G30.59395969
59TAF10.57418966
60CAMK1D0.57417177
61DAPK30.57320504
62JAK30.57164578
63MAP3K50.54632367
64SYK0.49351753
65TGFBR10.48017512
66ALK0.48001774
67MAP2K60.47211184
68MOS0.46134099
69CLK10.45510189
70STK40.44499197
71PRKD30.44434782
72BRD40.42770852
73LCK0.40320402
74BCKDK0.39347816
75MKNK10.38917410
76WNK30.38221912
77TGFBR20.37951842
78GRK10.37189939
79CHUK0.35965036
80CSNK2A10.34060587
81TESK20.33903624
82DYRK30.33137931
83CSNK2A20.31429256
84CSF1R0.30256625
85PRKCZ0.30097866
86CSNK1G20.29718262
87CAMKK20.28770867
88PRKG20.28554929
89GSK3A0.28136153
90RPS6KA60.26704288
91EPHB20.25985759
92GRK50.25618175
93CAMK2G0.22902471
94CDK40.22622822
95RPS6KL10.22042800
96RPS6KC10.22042800
97MAP3K40.21291021
98MKNK20.20902306
99KIT0.20729219
100PASK0.20463990

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38871681
2Asthma_Homo sapiens_hsa053104.16621291
3Allograft rejection_Homo sapiens_hsa053303.66123653
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.07862094
5Autoimmune thyroid disease_Homo sapiens_hsa053202.94815854
6Oxidative phosphorylation_Homo sapiens_hsa001902.58321153
7Rheumatoid arthritis_Homo sapiens_hsa053232.57219995
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42856100
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37230053
10Leishmaniasis_Homo sapiens_hsa051402.24646567
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.14158136
12Parkinsons disease_Homo sapiens_hsa050122.07044978
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06126550
14Graft-versus-host disease_Homo sapiens_hsa053321.93247112
15Staphylococcus aureus infection_Homo sapiens_hsa051501.83296031
16Lysosome_Homo sapiens_hsa041421.80373555
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.72982325
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67902183
19Type I diabetes mellitus_Homo sapiens_hsa049401.67418067
20RNA polymerase_Homo sapiens_hsa030201.63348870
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62535964
22Malaria_Homo sapiens_hsa051441.61305412
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58600414
24Osteoclast differentiation_Homo sapiens_hsa043801.58315819
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54415551
26Other glycan degradation_Homo sapiens_hsa005111.52144907
27Legionellosis_Homo sapiens_hsa051341.47717318
28One carbon pool by folate_Homo sapiens_hsa006701.45506000
29Proteasome_Homo sapiens_hsa030501.44244536
30Collecting duct acid secretion_Homo sapiens_hsa049661.42327369
31Hematopoietic cell lineage_Homo sapiens_hsa046401.34707142
32TNF signaling pathway_Homo sapiens_hsa046681.33425633
33DNA replication_Homo sapiens_hsa030301.32005853
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28178267
35Pertussis_Homo sapiens_hsa051331.26605635
36African trypanosomiasis_Homo sapiens_hsa051431.26367163
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23720035
38Base excision repair_Homo sapiens_hsa034101.22768197
39Huntingtons disease_Homo sapiens_hsa050161.22030278
40Tuberculosis_Homo sapiens_hsa051521.21794467
41Alzheimers disease_Homo sapiens_hsa050101.21406013
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17442640
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11214291
44Pyrimidine metabolism_Homo sapiens_hsa002401.10205853
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04489179
46Protein export_Homo sapiens_hsa030600.99114218
47Primary immunodeficiency_Homo sapiens_hsa053400.96569596
48Influenza A_Homo sapiens_hsa051640.92630597
49Antigen processing and presentation_Homo sapiens_hsa046120.92555491
50Herpes simplex infection_Homo sapiens_hsa051680.91020944
51Toxoplasmosis_Homo sapiens_hsa051450.90510624
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88529908
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87559744
54Sulfur relay system_Homo sapiens_hsa041220.87331094
55Salmonella infection_Homo sapiens_hsa051320.87174828
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.85313498
57Epstein-Barr virus infection_Homo sapiens_hsa051690.82826029
58Viral myocarditis_Homo sapiens_hsa054160.81540073
59Phagosome_Homo sapiens_hsa041450.80938794
60Measles_Homo sapiens_hsa051620.77232093
61Tryptophan metabolism_Homo sapiens_hsa003800.76513520
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.74956437
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71449464
64Chemokine signaling pathway_Homo sapiens_hsa040620.59606719
65Sulfur metabolism_Homo sapiens_hsa009200.58941728
66beta-Alanine metabolism_Homo sapiens_hsa004100.55078442
67Steroid biosynthesis_Homo sapiens_hsa001000.53949019
68Prion diseases_Homo sapiens_hsa050200.52967535
69Systemic lupus erythematosus_Homo sapiens_hsa053220.52256272
70RNA degradation_Homo sapiens_hsa030180.50275162
71Spliceosome_Homo sapiens_hsa030400.49106794
72Hepatitis C_Homo sapiens_hsa051600.46826677
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45492532
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.45169685
75T cell receptor signaling pathway_Homo sapiens_hsa046600.45053051
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40151163
77Bladder cancer_Homo sapiens_hsa052190.39827657
78Sphingolipid metabolism_Homo sapiens_hsa006000.39356194
79TGF-beta signaling pathway_Homo sapiens_hsa043500.38508732
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37320386
81Mineral absorption_Homo sapiens_hsa049780.37289749
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37235847
83Fatty acid degradation_Homo sapiens_hsa000710.35535544
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34915207
85Complement and coagulation cascades_Homo sapiens_hsa046100.33971406
86Pyruvate metabolism_Homo sapiens_hsa006200.32956112
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32011718
88Tyrosine metabolism_Homo sapiens_hsa003500.30423347
89Folate biosynthesis_Homo sapiens_hsa007900.30396668
90HTLV-I infection_Homo sapiens_hsa051660.29429635
91Glutathione metabolism_Homo sapiens_hsa004800.28762816
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28396165
93RNA transport_Homo sapiens_hsa030130.28039857
94Apoptosis_Homo sapiens_hsa042100.27144421
95Purine metabolism_Homo sapiens_hsa002300.26842174
96Arginine and proline metabolism_Homo sapiens_hsa003300.25889678
97Shigellosis_Homo sapiens_hsa051310.24724615
98Vibrio cholerae infection_Homo sapiens_hsa051100.24695152
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.22950357
100Phenylalanine metabolism_Homo sapiens_hsa003600.18834121

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