

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 7.32432076 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.80401861 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.55218662 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.55218662 |
| 5 | viral transcription (GO:0019083) | 5.17596992 |
| 6 | translational termination (GO:0006415) | 4.99625335 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.90556689 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.79557406 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.70901756 |
| 10 | cotranslational protein targeting to membrane (GO:0006613) | 4.70614297 |
| 11 | protein targeting to ER (GO:0045047) | 4.66245327 |
| 12 | DNA deamination (GO:0045006) | 4.64986535 |
| 13 | ribosomal large subunit biogenesis (GO:0042273) | 4.62057597 |
| 14 | translational elongation (GO:0006414) | 4.57417003 |
| 15 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.50016810 |
| 16 | proteasome assembly (GO:0043248) | 4.47918273 |
| 17 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.45028948 |
| 18 | protein localization to endoplasmic reticulum (GO:0070972) | 4.42305911 |
| 19 | chaperone-mediated protein transport (GO:0072321) | 4.33410322 |
| 20 | respiratory electron transport chain (GO:0022904) | 4.31567642 |
| 21 | electron transport chain (GO:0022900) | 4.22546328 |
| 22 | protein complex biogenesis (GO:0070271) | 4.22023211 |
| 23 | ribosomal small subunit biogenesis (GO:0042274) | 4.09749609 |
| 24 | regulation of mitochondrial translation (GO:0070129) | 4.05848420 |
| 25 | translational initiation (GO:0006413) | 4.02329941 |
| 26 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.00351058 |
| 27 | NADH dehydrogenase complex assembly (GO:0010257) | 3.99960363 |
| 28 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.99960363 |
| 29 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.99960363 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.96856367 |
| 31 | termination of RNA polymerase III transcription (GO:0006386) | 3.96856367 |
| 32 | translation (GO:0006412) | 3.96374795 |
| 33 | viral life cycle (GO:0019058) | 3.83861147 |
| 34 | protein neddylation (GO:0045116) | 3.75851432 |
| 35 | peptidyl-histidine modification (GO:0018202) | 3.74608440 |
| 36 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.67497071 |
| 37 | cellular protein complex disassembly (GO:0043624) | 3.67246777 |
| 38 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.62474552 |
| 39 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.62124062 |
| 40 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.62124062 |
| 41 | respiratory chain complex IV assembly (GO:0008535) | 3.62033793 |
| 42 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.57560787 |
| 43 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.56910203 |
| 44 | pseudouridine synthesis (GO:0001522) | 3.50100185 |
| 45 | cytochrome complex assembly (GO:0017004) | 3.37986441 |
| 46 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.37520692 |
| 47 | protein-cofactor linkage (GO:0018065) | 3.34786159 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.34042234 |
| 49 | negative regulation of ligase activity (GO:0051352) | 3.34042234 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.31962170 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.29874780 |
| 52 | cellular component biogenesis (GO:0044085) | 3.28621059 |
| 53 | CENP-A containing nucleosome assembly (GO:0034080) | 3.26203410 |
| 54 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.23881930 |
| 55 | chromatin remodeling at centromere (GO:0031055) | 3.22553920 |
| 56 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.21579785 |
| 57 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.21579785 |
| 58 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.21579785 |
| 59 | protein targeting to mitochondrion (GO:0006626) | 3.17329610 |
| 60 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.15073043 |
| 61 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.15073043 |
| 62 | rRNA processing (GO:0006364) | 3.13664055 |
| 63 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.10784651 |
| 64 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.10784651 |
| 65 | rRNA metabolic process (GO:0016072) | 3.06903776 |
| 66 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.06109594 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.05942844 |
| 68 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.04564118 |
| 69 | formation of translation preinitiation complex (GO:0001731) | 3.04262412 |
| 70 | protein targeting to membrane (GO:0006612) | 3.03954412 |
| 71 | rRNA modification (GO:0000154) | 3.03786089 |
| 72 | protein complex disassembly (GO:0043241) | 3.03745828 |
| 73 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.02895758 |
| 74 | protein deneddylation (GO:0000338) | 3.02871668 |
| 75 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.02398735 |
| 76 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01730408 |
| 77 | ATP biosynthetic process (GO:0006754) | 3.01667140 |
| 78 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.00896532 |
| 79 | platelet dense granule organization (GO:0060155) | 3.00854182 |
| 80 | GTP biosynthetic process (GO:0006183) | 2.98456275 |
| 81 | cullin deneddylation (GO:0010388) | 2.98253305 |
| 82 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.96469222 |
| 83 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.94468459 |
| 84 | response to interferon-beta (GO:0035456) | 2.93915873 |
| 85 | maturation of 5.8S rRNA (GO:0000460) | 2.93616696 |
| 86 | macromolecular complex disassembly (GO:0032984) | 2.90720831 |
| 87 | spliceosomal snRNP assembly (GO:0000387) | 2.90415776 |
| 88 | oxidative phosphorylation (GO:0006119) | 2.89108677 |
| 89 | protein localization to mitochondrion (GO:0070585) | 2.88042388 |
| 90 | mannosylation (GO:0097502) | 2.87792386 |
| 91 | GPI anchor biosynthetic process (GO:0006506) | 2.85357291 |
| 92 | viral mRNA export from host cell nucleus (GO:0046784) | 2.85061613 |
| 93 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.83845636 |
| 94 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.83640454 |
| 95 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.82233773 |
| 96 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.80878245 |
| 97 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.80034595 |
| 98 | hydrogen ion transmembrane transport (GO:1902600) | 2.79963993 |
| 99 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.79758828 |
| 100 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.78873210 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.99214822 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.76898470 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.25468111 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.58874682 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.55127571 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.55036895 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.37153313 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.36423788 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 3.10381200 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.08275862 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.01277940 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.99856118 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.97512738 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.95128971 |
| 15 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.76428566 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.74631551 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.58302976 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.47333207 |
| 19 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.41798219 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.38040890 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.35870657 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.26698383 |
| 23 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.23618459 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.18206207 |
| 25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.17858491 |
| 26 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.15331693 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.15178689 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.11875205 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.98568303 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.98190356 |
| 31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.88536218 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.84981914 |
| 33 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.83246418 |
| 34 | VDR_22108803_ChIP-Seq_LS180_Human | 1.78210372 |
| 35 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.75957418 |
| 36 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.73503059 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.68601407 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.67097952 |
| 39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.67090762 |
| 40 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.65336416 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64741030 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61611877 |
| 43 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.60681542 |
| 44 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.49067481 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.48135681 |
| 46 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.46655026 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.44658139 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44610132 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.43793247 |
| 50 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36870099 |
| 51 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.36679534 |
| 52 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.34977032 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.34753228 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.33782307 |
| 55 | EWS_26573619_Chip-Seq_HEK293_Human | 1.32505067 |
| 56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27762200 |
| 57 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.23370715 |
| 58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22545665 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.16084063 |
| 60 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.15072163 |
| 61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.14892697 |
| 62 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13823768 |
| 63 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.13621441 |
| 64 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.10975422 |
| 65 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.10728404 |
| 66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09457389 |
| 67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08980750 |
| 68 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.05139196 |
| 69 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04357768 |
| 70 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.04335834 |
| 71 | AR_20517297_ChIP-Seq_VCAP_Human | 1.01558136 |
| 72 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.00775568 |
| 73 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00455330 |
| 74 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00455330 |
| 75 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.00000806 |
| 76 | FUS_26573619_Chip-Seq_HEK293_Human | 0.99481467 |
| 77 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.99335868 |
| 78 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.98328145 |
| 79 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.96514502 |
| 80 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.96254304 |
| 81 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.95250802 |
| 82 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92149460 |
| 83 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.91990816 |
| 84 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91323935 |
| 85 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.90950660 |
| 86 | GATA3_26560356_Chip-Seq_TH2_Human | 0.89930238 |
| 87 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.88144140 |
| 88 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.87791815 |
| 89 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87759989 |
| 90 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.86630795 |
| 91 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.86126919 |
| 92 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.81104435 |
| 93 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.79708308 |
| 94 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.79708308 |
| 95 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.79413710 |
| 96 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.79350066 |
| 97 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.78973844 |
| 98 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.78850060 |
| 99 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.78459028 |
| 100 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.76756093 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 3.99298298 |
| 2 | MP0006292_abnormal_olfactory_placode | 3.26693231 |
| 3 | MP0002837_dystrophic_cardiac_calcinosis | 3.05655123 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 2.96188874 |
| 5 | MP0005084_abnormal_gallbladder_morpholo | 2.78148636 |
| 6 | MP0002102_abnormal_ear_morphology | 2.73544475 |
| 7 | MP0006072_abnormal_retinal_apoptosis | 2.66288343 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.50261730 |
| 9 | MP0008058_abnormal_DNA_repair | 2.36226449 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.29032398 |
| 11 | MP0005671_abnormal_response_to | 2.23544574 |
| 12 | MP0008057_abnormal_DNA_replication | 2.21896679 |
| 13 | MP0005075_abnormal_melanosome_morpholog | 2.20753006 |
| 14 | MP0008877_abnormal_DNA_methylation | 2.15617819 |
| 15 | MP0002138_abnormal_hepatobiliary_system | 2.13677026 |
| 16 | MP0004957_abnormal_blastocyst_morpholog | 2.08721907 |
| 17 | MP0002277_abnormal_respiratory_mucosa | 2.08695050 |
| 18 | MP0003786_premature_aging | 2.07513437 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 1.98137794 |
| 20 | MP0003283_abnormal_digestive_organ | 1.91420409 |
| 21 | MP0003186_abnormal_redox_activity | 1.89128791 |
| 22 | MP0000372_irregular_coat_pigmentation | 1.87450016 |
| 23 | MP0010094_abnormal_chromosome_stability | 1.85675403 |
| 24 | MP0003011_delayed_dark_adaptation | 1.77038899 |
| 25 | MP0008872_abnormal_physiological_respon | 1.73790047 |
| 26 | MP0009333_abnormal_splenocyte_physiolog | 1.73151462 |
| 27 | MP0003111_abnormal_nucleus_morphology | 1.72260664 |
| 28 | MP0006035_abnormal_mitochondrial_morpho | 1.67547524 |
| 29 | MP0001764_abnormal_homeostasis | 1.67321345 |
| 30 | MP0002163_abnormal_gland_morphology | 1.66388107 |
| 31 | MP0001293_anophthalmia | 1.61635090 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.54346239 |
| 33 | MP0001529_abnormal_vocalization | 1.53968918 |
| 34 | MP0002736_abnormal_nociception_after | 1.51751763 |
| 35 | MP0001986_abnormal_taste_sensitivity | 1.46758244 |
| 36 | MP0002148_abnormal_hypersensitivity_rea | 1.37415300 |
| 37 | MP0003763_abnormal_thymus_physiology | 1.32873064 |
| 38 | MP0003077_abnormal_cell_cycle | 1.31689221 |
| 39 | MP0003195_calcinosis | 1.31621513 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.29584596 |
| 41 | MP0003787_abnormal_imprinting | 1.29162979 |
| 42 | MP0002006_tumorigenesis | 1.28055378 |
| 43 | MP0002166_altered_tumor_susceptibility | 1.27067391 |
| 44 | MP0005253_abnormal_eye_physiology | 1.26699856 |
| 45 | MP0001968_abnormal_touch/_nociception | 1.25012865 |
| 46 | MP0001919_abnormal_reproductive_system | 1.24871212 |
| 47 | MP0008007_abnormal_cellular_replicative | 1.17763252 |
| 48 | MP0000516_abnormal_urinary_system | 1.17744544 |
| 49 | MP0005367_renal/urinary_system_phenotyp | 1.17744544 |
| 50 | MP0005389_reproductive_system_phenotype | 1.17487162 |
| 51 | MP0001873_stomach_inflammation | 1.15451879 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 1.12965248 |
| 53 | MP0004142_abnormal_muscle_tone | 1.12749408 |
| 54 | MP0002693_abnormal_pancreas_physiology | 1.07814582 |
| 55 | MP0009785_altered_susceptibility_to | 1.06612919 |
| 56 | MP0002938_white_spotting | 1.03862840 |
| 57 | MP0008932_abnormal_embryonic_tissue | 1.03798681 |
| 58 | MP0003718_maternal_effect | 1.03574942 |
| 59 | MP0005379_endocrine/exocrine_gland_phen | 1.03396122 |
| 60 | MP0005332_abnormal_amino_acid | 0.99234854 |
| 61 | MP0005551_abnormal_eye_electrophysiolog | 0.97095698 |
| 62 | MP0005000_abnormal_immune_tolerance | 0.96267649 |
| 63 | MP0005220_abnormal_exocrine_pancreas | 0.94308849 |
| 64 | MP0001800_abnormal_humoral_immune | 0.92938799 |
| 65 | MP0000358_abnormal_cell_content/ | 0.92355598 |
| 66 | MP0000427_abnormal_hair_cycle | 0.92204280 |
| 67 | MP0004145_abnormal_muscle_electrophysio | 0.87981485 |
| 68 | MP0000013_abnormal_adipose_tissue | 0.86244645 |
| 69 | MP0001819_abnormal_immune_cell | 0.85147203 |
| 70 | MP0002160_abnormal_reproductive_system | 0.84447849 |
| 71 | MP0001929_abnormal_gametogenesis | 0.83236858 |
| 72 | MP0002420_abnormal_adaptive_immunity | 0.83169173 |
| 73 | MP0003252_abnormal_bile_duct | 0.83162880 |
| 74 | MP0002396_abnormal_hematopoietic_system | 0.82212083 |
| 75 | MP0005636_abnormal_mineral_homeostasis | 0.81984257 |
| 76 | MP0002723_abnormal_immune_serum | 0.81739421 |
| 77 | MP0002210_abnormal_sex_determination | 0.81461808 |
| 78 | MP0000689_abnormal_spleen_morphology | 0.79264644 |
| 79 | MP0001188_hyperpigmentation | 0.79162986 |
| 80 | MP0008995_early_reproductive_senescence | 0.78900108 |
| 81 | MP0009697_abnormal_copulation | 0.78108728 |
| 82 | MP0002398_abnormal_bone_marrow | 0.77590158 |
| 83 | MP0000490_abnormal_crypts_of | 0.77220920 |
| 84 | MP0003866_abnormal_defecation | 0.76265752 |
| 85 | MP0001944_abnormal_pancreas_morphology | 0.76011275 |
| 86 | MP0006082_CNS_inflammation | 0.75700575 |
| 87 | MP0000703_abnormal_thymus_morphology | 0.75612506 |
| 88 | MP0001485_abnormal_pinna_reflex | 0.75387453 |
| 89 | MP0002452_abnormal_antigen_presenting | 0.75262378 |
| 90 | MP0002876_abnormal_thyroid_physiology | 0.74884113 |
| 91 | MP0002090_abnormal_vision | 0.74788766 |
| 92 | MP0005085_abnormal_gallbladder_physiolo | 0.73610195 |
| 93 | MP0000653_abnormal_sex_gland | 0.73554477 |
| 94 | MP0002132_abnormal_respiratory_system | 0.73461664 |
| 95 | MP0001145_abnormal_male_reproductive | 0.73260957 |
| 96 | MP0003121_genomic_imprinting | 0.72799993 |
| 97 | MP0002019_abnormal_tumor_incidence | 0.71204832 |
| 98 | MP0000716_abnormal_immune_system | 0.71075853 |
| 99 | MP0003123_paternal_imprinting | 0.69697063 |
| 100 | MP0008873_increased_physiological_sensi | 0.66436929 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.04700559 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.76029625 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.50439668 |
| 4 | Increased CSF lactate (HP:0002490) | 4.36523186 |
| 5 | Hepatocellular necrosis (HP:0001404) | 4.35753170 |
| 6 | Acute encephalopathy (HP:0006846) | 4.27736303 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.27444690 |
| 8 | Hepatic necrosis (HP:0002605) | 4.17918215 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.01742695 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.70421894 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.58065477 |
| 12 | Cerebral edema (HP:0002181) | 3.46649238 |
| 13 | Congenital, generalized hypertrichosis (HP:0004540) | 3.43482937 |
| 14 | Abnormal number of erythroid precursors (HP:0012131) | 3.41512161 |
| 15 | Reticulocytopenia (HP:0001896) | 3.35883784 |
| 16 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.32206236 |
| 17 | Methylmalonic acidemia (HP:0002912) | 3.27149741 |
| 18 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.22644704 |
| 19 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.22644704 |
| 20 | Type I transferrin isoform profile (HP:0003642) | 3.21857704 |
| 21 | Aplastic anemia (HP:0001915) | 3.08704760 |
| 22 | Increased serum lactate (HP:0002151) | 3.06259692 |
| 23 | Lactic acidosis (HP:0003128) | 2.94450765 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 2.91738865 |
| 25 | Macrocytic anemia (HP:0001972) | 2.91014017 |
| 26 | Colon cancer (HP:0003003) | 2.87896296 |
| 27 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.80162419 |
| 28 | Optic disc pallor (HP:0000543) | 2.77873251 |
| 29 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.77637929 |
| 30 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.77637929 |
| 31 | Abnormal protein glycosylation (HP:0012346) | 2.77637929 |
| 32 | Abnormal glycosylation (HP:0012345) | 2.77637929 |
| 33 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.68706218 |
| 34 | Respiratory failure (HP:0002878) | 2.67975716 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.66118851 |
| 36 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.61970001 |
| 37 | Methylmalonic aciduria (HP:0012120) | 2.61883559 |
| 38 | Pancytopenia (HP:0001876) | 2.60905698 |
| 39 | Exertional dyspnea (HP:0002875) | 2.56877561 |
| 40 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.52537997 |
| 41 | Respiratory difficulties (HP:0002880) | 2.51588229 |
| 42 | IgG deficiency (HP:0004315) | 2.50273030 |
| 43 | Reduced antithrombin III activity (HP:0001976) | 2.40949561 |
| 44 | Lethargy (HP:0001254) | 2.39313661 |
| 45 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.31851764 |
| 46 | Leukodystrophy (HP:0002415) | 2.26599123 |
| 47 | Exercise intolerance (HP:0003546) | 2.25744515 |
| 48 | Abolished electroretinogram (ERG) (HP:0000550) | 2.24659770 |
| 49 | Pancreatic cysts (HP:0001737) | 2.22595111 |
| 50 | Oral leukoplakia (HP:0002745) | 2.21867814 |
| 51 | Hyperglycinemia (HP:0002154) | 2.20031474 |
| 52 | Hypoglycemic coma (HP:0001325) | 2.19624162 |
| 53 | Abnormality of alanine metabolism (HP:0010916) | 2.17819632 |
| 54 | Hyperalaninemia (HP:0003348) | 2.17819632 |
| 55 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.17819632 |
| 56 | Renal cortical cysts (HP:0000803) | 2.17452234 |
| 57 | B lymphocytopenia (HP:0010976) | 2.17338658 |
| 58 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.12487280 |
| 59 | Constricted visual fields (HP:0001133) | 2.12095062 |
| 60 | Microvesicular hepatic steatosis (HP:0001414) | 2.09856905 |
| 61 | Abnormality of vitamin B metabolism (HP:0004340) | 2.07893719 |
| 62 | Increased muscle lipid content (HP:0009058) | 2.07854486 |
| 63 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.06681679 |
| 64 | Dicarboxylic aciduria (HP:0003215) | 2.06681679 |
| 65 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.05864388 |
| 66 | Severe combined immunodeficiency (HP:0004430) | 2.04857285 |
| 67 | Abnormality of serum amino acid levels (HP:0003112) | 2.04521124 |
| 68 | Glycosuria (HP:0003076) | 2.02979366 |
| 69 | Abnormality of urine glucose concentration (HP:0011016) | 2.02979366 |
| 70 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.02671543 |
| 71 | CNS demyelination (HP:0007305) | 2.00546411 |
| 72 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.00204001 |
| 73 | Congenital stationary night blindness (HP:0007642) | 1.96740747 |
| 74 | Testicular atrophy (HP:0000029) | 1.95044299 |
| 75 | Septo-optic dysplasia (HP:0100842) | 1.94361370 |
| 76 | Rectal fistula (HP:0100590) | 1.93885427 |
| 77 | Rectovaginal fistula (HP:0000143) | 1.93885427 |
| 78 | Abnormality of B cell number (HP:0010975) | 1.93334839 |
| 79 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.91696056 |
| 80 | Generalized aminoaciduria (HP:0002909) | 1.89034338 |
| 81 | Pallor (HP:0000980) | 1.88101108 |
| 82 | Delayed CNS myelination (HP:0002188) | 1.87751249 |
| 83 | Stomatitis (HP:0010280) | 1.87386454 |
| 84 | Abnormality of the renal cortex (HP:0011035) | 1.86259736 |
| 85 | Hypoproteinemia (HP:0003075) | 1.80816181 |
| 86 | Ketosis (HP:0001946) | 1.80705045 |
| 87 | Hypoglycemic seizures (HP:0002173) | 1.80178050 |
| 88 | Molar tooth sign on MRI (HP:0002419) | 1.78451140 |
| 89 | Abnormality of midbrain morphology (HP:0002418) | 1.78451140 |
| 90 | Microretrognathia (HP:0000308) | 1.77603703 |
| 91 | IgM deficiency (HP:0002850) | 1.76243632 |
| 92 | Abnormality of renal resorption (HP:0011038) | 1.76179768 |
| 93 | Ketoacidosis (HP:0001993) | 1.74937628 |
| 94 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.74247080 |
| 95 | Maternal diabetes (HP:0009800) | 1.73578394 |
| 96 | Rough bone trabeculation (HP:0100670) | 1.73492544 |
| 97 | Large for gestational age (HP:0001520) | 1.73063557 |
| 98 | Abnormality of methionine metabolism (HP:0010901) | 1.72537201 |
| 99 | Triphalangeal thumb (HP:0001199) | 1.71195373 |
| 100 | Pancreatic fibrosis (HP:0100732) | 1.70526019 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.21137802 |
| 2 | ZAK | 3.63535822 |
| 3 | TLK1 | 3.23239960 |
| 4 | STK16 | 3.02452339 |
| 5 | MAP4K2 | 2.91145940 |
| 6 | NUAK1 | 2.86770791 |
| 7 | MAP3K12 | 2.56525156 |
| 8 | PASK | 2.51394422 |
| 9 | BUB1 | 2.46503381 |
| 10 | MST4 | 2.31611368 |
| 11 | NME2 | 2.29916029 |
| 12 | PBK | 2.24955605 |
| 13 | PLK4 | 2.21780996 |
| 14 | BCKDK | 2.19174247 |
| 15 | EIF2AK3 | 2.05157155 |
| 16 | CDK19 | 1.91038077 |
| 17 | KDR | 1.90540137 |
| 18 | TXK | 1.88575579 |
| 19 | VRK1 | 1.84921482 |
| 20 | SRPK1 | 1.84177141 |
| 21 | TAF1 | 1.82771065 |
| 22 | CDC7 | 1.64620667 |
| 23 | TESK2 | 1.58520562 |
| 24 | GRK1 | 1.54074592 |
| 25 | ADRBK2 | 1.45600006 |
| 26 | ILK | 1.40657586 |
| 27 | TSSK6 | 1.34895340 |
| 28 | FRK | 1.28267818 |
| 29 | MAP4K1 | 1.20511927 |
| 30 | EIF2AK1 | 1.19738478 |
| 31 | INSRR | 1.15476142 |
| 32 | PLK3 | 1.15472924 |
| 33 | MAP3K9 | 1.07121607 |
| 34 | LIMK1 | 1.06853791 |
| 35 | MYLK | 1.06314982 |
| 36 | OXSR1 | 1.06057889 |
| 37 | TAOK3 | 1.05847849 |
| 38 | TRIM28 | 1.03219171 |
| 39 | IKBKB | 0.99988667 |
| 40 | GRK6 | 0.99147225 |
| 41 | MUSK | 0.98834075 |
| 42 | TTK | 0.87965221 |
| 43 | DAPK1 | 0.87569430 |
| 44 | BMPR1B | 0.84707440 |
| 45 | BMPR2 | 0.82937080 |
| 46 | WNK3 | 0.80047229 |
| 47 | ARAF | 0.79619101 |
| 48 | PINK1 | 0.79497588 |
| 49 | SCYL2 | 0.77764678 |
| 50 | PHKG1 | 0.77403225 |
| 51 | PHKG2 | 0.77403225 |
| 52 | PLK1 | 0.76619265 |
| 53 | AURKB | 0.74610853 |
| 54 | TEC | 0.72123806 |
| 55 | ITK | 0.71121923 |
| 56 | EIF2AK2 | 0.69746473 |
| 57 | NEK1 | 0.68885832 |
| 58 | MKNK1 | 0.67964016 |
| 59 | ATR | 0.67937663 |
| 60 | RPS6KA4 | 0.66854763 |
| 61 | TESK1 | 0.66170462 |
| 62 | CSNK1G1 | 0.66154681 |
| 63 | CSNK1G3 | 0.63057855 |
| 64 | WNK4 | 0.61707472 |
| 65 | ERBB3 | 0.59438900 |
| 66 | PLK2 | 0.59378656 |
| 67 | CSNK2A2 | 0.59087205 |
| 68 | PRKCQ | 0.58591439 |
| 69 | RPS6KA5 | 0.58554973 |
| 70 | RPS6KB2 | 0.58317896 |
| 71 | CDK8 | 0.57096763 |
| 72 | KIT | 0.56180497 |
| 73 | FLT3 | 0.55190694 |
| 74 | CSNK2A1 | 0.54378025 |
| 75 | ADRBK1 | 0.54273165 |
| 76 | CHEK2 | 0.54107740 |
| 77 | STK39 | 0.52881916 |
| 78 | CSNK1G2 | 0.52875446 |
| 79 | AURKA | 0.52699156 |
| 80 | MKNK2 | 0.50576371 |
| 81 | CSF1R | 0.49113702 |
| 82 | BRAF | 0.46082324 |
| 83 | DAPK3 | 0.44172420 |
| 84 | TGFBR1 | 0.42499640 |
| 85 | ABL2 | 0.39936592 |
| 86 | STK4 | 0.39754518 |
| 87 | MAP2K2 | 0.39632838 |
| 88 | TNK2 | 0.38616715 |
| 89 | CDK7 | 0.37969312 |
| 90 | NEK2 | 0.37931131 |
| 91 | WEE1 | 0.36583835 |
| 92 | MAP2K6 | 0.34954156 |
| 93 | TRPM7 | 0.34637270 |
| 94 | ATM | 0.33501164 |
| 95 | MAP2K7 | 0.32974222 |
| 96 | IKBKE | 0.31404921 |
| 97 | PIK3CG | 0.30681268 |
| 98 | PRKCI | 0.30350539 |
| 99 | PRKCE | 0.30043754 |
| 100 | STK3 | 0.29870916 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.80758622 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.36308032 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.03202753 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.31423835 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.01907204 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.51896756 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.25736330 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.17059755 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.14040364 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.13503261 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 2.06808325 |
| 12 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.96440213 |
| 13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.95650710 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.94694804 |
| 15 | Asthma_Homo sapiens_hsa05310 | 1.90254122 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.80969744 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.78262124 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.76132587 |
| 19 | Allograft rejection_Homo sapiens_hsa05330 | 1.69654515 |
| 20 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.64761936 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.63809131 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.62819333 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.59632074 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57984842 |
| 25 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.57314414 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.54056431 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50858357 |
| 28 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.50592818 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.49392872 |
| 30 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.48012307 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.46721379 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.45060299 |
| 33 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.44784144 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.40417036 |
| 35 | Basal transcription factors_Homo sapiens_hsa03022 | 1.35382416 |
| 36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.32102275 |
| 37 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.16528517 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.14007759 |
| 39 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.10733467 |
| 40 | Peroxisome_Homo sapiens_hsa04146 | 1.06861075 |
| 41 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.01578602 |
| 42 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.99325911 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97004354 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 0.93029090 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.91673004 |
| 46 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.90402443 |
| 47 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.81840582 |
| 48 | Sulfur relay system_Homo sapiens_hsa04122 | 0.79435273 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.79156882 |
| 50 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.79114178 |
| 51 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.79055406 |
| 52 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.78176077 |
| 53 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.75660044 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74474081 |
| 55 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.74270203 |
| 56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.69101847 |
| 57 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.63575867 |
| 58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.59797811 |
| 59 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.59737103 |
| 60 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.59385821 |
| 61 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59105644 |
| 62 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.57417495 |
| 63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.56588938 |
| 64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.56279131 |
| 65 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.53929677 |
| 66 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53520439 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.52990278 |
| 68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.52205486 |
| 69 | Viral myocarditis_Homo sapiens_hsa05416 | 0.51927960 |
| 70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.51272145 |
| 71 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50817853 |
| 72 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.48651989 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47260804 |
| 74 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.46343819 |
| 75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.45554267 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43997360 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.42739238 |
| 78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42557448 |
| 79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.42515043 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41447712 |
| 81 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.39908309 |
| 82 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39488511 |
| 83 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.38971061 |
| 84 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.36460591 |
| 85 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.36451445 |
| 86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.36266837 |
| 87 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36054259 |
| 88 | Cell cycle_Homo sapiens_hsa04110 | 0.35138380 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.34412382 |
| 90 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.32097612 |
| 91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.30917697 |
| 92 | Carbon metabolism_Homo sapiens_hsa01200 | 0.29177840 |
| 93 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25320069 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.22637703 |
| 95 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.22635714 |
| 96 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.19758955 |
| 97 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.18197352 |
| 98 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.15438122 |
| 99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.15437781 |
| 100 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.15304627 |

