

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 7.13212009 |
| 2 | DNA deamination (GO:0045006) | 6.95953009 |
| 3 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.97286803 |
| 4 | cytidine catabolic process (GO:0006216) | 5.00490614 |
| 5 | cytidine deamination (GO:0009972) | 5.00490614 |
| 6 | cytidine metabolic process (GO:0046087) | 5.00490614 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 4.76613942 |
| 8 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.76613942 |
| 9 | chaperone-mediated protein transport (GO:0072321) | 4.75331369 |
| 10 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.73091134 |
| 11 | viral transcription (GO:0019083) | 4.57648996 |
| 12 | ribosomal small subunit biogenesis (GO:0042274) | 4.48627619 |
| 13 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.45118272 |
| 14 | translational termination (GO:0006415) | 4.44864840 |
| 15 | protein complex biogenesis (GO:0070271) | 4.30968124 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.25104421 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.25104421 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 4.25104421 |
| 19 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.22919860 |
| 20 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.18687481 |
| 21 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.18687481 |
| 22 | translational elongation (GO:0006414) | 4.13070905 |
| 23 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.02798079 |
| 24 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.00844558 |
| 25 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.99499974 |
| 26 | maturation of SSU-rRNA (GO:0030490) | 3.97616451 |
| 27 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.96767290 |
| 28 | cotranslational protein targeting to membrane (GO:0006613) | 3.92684525 |
| 29 | protein targeting to ER (GO:0045047) | 3.91830151 |
| 30 | proteasome assembly (GO:0043248) | 3.87151150 |
| 31 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.71481271 |
| 32 | respiratory electron transport chain (GO:0022904) | 3.70827089 |
| 33 | protein localization to endoplasmic reticulum (GO:0070972) | 3.68163676 |
| 34 | electron transport chain (GO:0022900) | 3.66783105 |
| 35 | protein neddylation (GO:0045116) | 3.63773863 |
| 36 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.63026476 |
| 37 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.57388986 |
| 38 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.51928427 |
| 39 | ncRNA 3-end processing (GO:0043628) | 3.48054139 |
| 40 | pseudouridine synthesis (GO:0001522) | 3.47244309 |
| 41 | GTP biosynthetic process (GO:0006183) | 3.44467144 |
| 42 | translation (GO:0006412) | 3.41673847 |
| 43 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.39792128 |
| 44 | translational initiation (GO:0006413) | 3.35410812 |
| 45 | viral life cycle (GO:0019058) | 3.34507268 |
| 46 | rRNA modification (GO:0000154) | 3.32890276 |
| 47 | cellular protein complex disassembly (GO:0043624) | 3.29310565 |
| 48 | deoxyribonucleotide catabolic process (GO:0009264) | 3.28622429 |
| 49 | respiratory chain complex IV assembly (GO:0008535) | 3.28266199 |
| 50 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.26933247 |
| 51 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.25726616 |
| 52 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.21071338 |
| 53 | cellular component biogenesis (GO:0044085) | 3.19654207 |
| 54 | response to pheromone (GO:0019236) | 3.18014605 |
| 55 | termination of RNA polymerase III transcription (GO:0006386) | 3.11956335 |
| 56 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.11956335 |
| 57 | deoxyribose phosphate catabolic process (GO:0046386) | 3.11613656 |
| 58 | base-excision repair, AP site formation (GO:0006285) | 3.09852195 |
| 59 | cytochrome complex assembly (GO:0017004) | 3.08723922 |
| 60 | behavioral response to nicotine (GO:0035095) | 3.03515331 |
| 61 | ubiquinone biosynthetic process (GO:0006744) | 3.03460603 |
| 62 | ribosomal large subunit biogenesis (GO:0042273) | 3.03218558 |
| 63 | rRNA processing (GO:0006364) | 3.00670170 |
| 64 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.99674498 |
| 65 | UTP biosynthetic process (GO:0006228) | 2.99207497 |
| 66 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.99115991 |
| 67 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.96671888 |
| 68 | rRNA metabolic process (GO:0016072) | 2.95151514 |
| 69 | peptidyl-histidine modification (GO:0018202) | 2.93080527 |
| 70 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.92994392 |
| 71 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.90483787 |
| 72 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.89410836 |
| 73 | protein targeting to mitochondrion (GO:0006626) | 2.86765349 |
| 74 | UTP metabolic process (GO:0046051) | 2.85228820 |
| 75 | mannosylation (GO:0097502) | 2.83667399 |
| 76 | negative regulation of telomere maintenance (GO:0032205) | 2.81001850 |
| 77 | platelet dense granule organization (GO:0060155) | 2.79423128 |
| 78 | regulation of mitochondrial translation (GO:0070129) | 2.76432128 |
| 79 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.75669412 |
| 80 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.73942737 |
| 81 | protein-cofactor linkage (GO:0018065) | 2.73812987 |
| 82 | ATP biosynthetic process (GO:0006754) | 2.73436411 |
| 83 | establishment of protein localization to mitochondrion (GO:0072655) | 2.73131235 |
| 84 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.69551863 |
| 85 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.69401905 |
| 86 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.69312579 |
| 87 | iron-sulfur cluster assembly (GO:0016226) | 2.67854323 |
| 88 | metallo-sulfur cluster assembly (GO:0031163) | 2.67854323 |
| 89 | piRNA metabolic process (GO:0034587) | 2.67537258 |
| 90 | negative regulation of ligase activity (GO:0051352) | 2.67514916 |
| 91 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.67514916 |
| 92 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.66440704 |
| 93 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.66440704 |
| 94 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.66440704 |
| 95 | protein complex disassembly (GO:0043241) | 2.65892937 |
| 96 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.65556978 |
| 97 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.62752476 |
| 98 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.62752476 |
| 99 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.62287618 |
| 100 | purine nucleotide salvage (GO:0032261) | 2.62047095 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.04946390 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.35027018 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.11505478 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.48372977 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.38835342 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.08055964 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.04891259 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.00644447 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.76870520 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.75275304 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.64608504 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.61160305 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.52035306 |
| 14 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.49997053 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.43834523 |
| 16 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.36778798 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33947283 |
| 18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.17168809 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.10775854 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.07825444 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.06130168 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.03639537 |
| 23 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.94927842 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.91305467 |
| 25 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.83139052 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.83065971 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.80273202 |
| 28 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.69041568 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.65034962 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.61864469 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.60740916 |
| 32 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.58925070 |
| 33 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.58288952 |
| 34 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.57784659 |
| 35 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.54850040 |
| 36 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.53236209 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.51651365 |
| 38 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.51381078 |
| 39 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.49750874 |
| 40 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.49736960 |
| 41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.48850776 |
| 42 | EWS_26573619_Chip-Seq_HEK293_Human | 1.46317384 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41859872 |
| 44 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40885880 |
| 45 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.39095318 |
| 46 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.37491186 |
| 47 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.34995344 |
| 48 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.32682505 |
| 49 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32450318 |
| 50 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.31814945 |
| 51 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.31814945 |
| 52 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.29656775 |
| 53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.28583242 |
| 54 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.27813777 |
| 55 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.27327995 |
| 56 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.26801739 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25091673 |
| 58 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.25009897 |
| 59 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.24872923 |
| 60 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.23845103 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.22507745 |
| 62 | AR_20517297_ChIP-Seq_VCAP_Human | 1.21973702 |
| 63 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.21809701 |
| 64 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.17944902 |
| 65 | NCOR_22424771_ChIP-Seq_293T_Human | 1.16037157 |
| 66 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.15958284 |
| 67 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.15786905 |
| 68 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.14738536 |
| 69 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.13239812 |
| 70 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.11373948 |
| 71 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.08971887 |
| 72 | GATA3_26560356_Chip-Seq_TH2_Human | 1.07236445 |
| 73 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.07145926 |
| 74 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.05761222 |
| 75 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.05302956 |
| 76 | FUS_26573619_Chip-Seq_HEK293_Human | 1.04555095 |
| 77 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.02722921 |
| 78 | MYB_26560356_Chip-Seq_TH2_Human | 1.01304544 |
| 79 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.99865642 |
| 80 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.99865642 |
| 81 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.99304259 |
| 82 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98030797 |
| 83 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.97188729 |
| 84 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.96551613 |
| 85 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.95833097 |
| 86 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.94277726 |
| 87 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.93381729 |
| 88 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.92277388 |
| 89 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.91997857 |
| 90 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.90841162 |
| 91 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.89990366 |
| 92 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.88404706 |
| 93 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.88380560 |
| 94 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88082509 |
| 95 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87847059 |
| 96 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.87384481 |
| 97 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.86940497 |
| 98 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.86547175 |
| 99 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86190474 |
| 100 | ERA_21632823_ChIP-Seq_H3396_Human | 0.85930475 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.55957068 |
| 2 | MP0002138_abnormal_hepatobiliary_system | 3.28766208 |
| 3 | MP0009379_abnormal_foot_pigmentation | 3.11816392 |
| 4 | MP0005671_abnormal_response_to | 3.00765328 |
| 5 | MP0005646_abnormal_pituitary_gland | 2.59091605 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.50962378 |
| 7 | MP0005084_abnormal_gallbladder_morpholo | 2.35780162 |
| 8 | MP0004147_increased_porphyrin_level | 2.25064207 |
| 9 | MP0003786_premature_aging | 2.11758110 |
| 10 | MP0002837_dystrophic_cardiac_calcinosis | 2.10868072 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.08016193 |
| 12 | MP0002163_abnormal_gland_morphology | 2.02671865 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.02592939 |
| 14 | MP0008058_abnormal_DNA_repair | 1.91714337 |
| 15 | MP0006072_abnormal_retinal_apoptosis | 1.73498467 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 1.73022949 |
| 17 | MP0005645_abnormal_hypothalamus_physiol | 1.72299785 |
| 18 | MP0001835_abnormal_antigen_presentation | 1.71020422 |
| 19 | MP0008872_abnormal_physiological_respon | 1.67931043 |
| 20 | MP0005551_abnormal_eye_electrophysiolog | 1.67066860 |
| 21 | MP0002102_abnormal_ear_morphology | 1.65758934 |
| 22 | MP0002876_abnormal_thyroid_physiology | 1.64675598 |
| 23 | MP0001764_abnormal_homeostasis | 1.61456362 |
| 24 | MP0002653_abnormal_ependyma_morphology | 1.61085524 |
| 25 | MP0001968_abnormal_touch/_nociception | 1.58344531 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.57826367 |
| 27 | MP0005379_endocrine/exocrine_gland_phen | 1.53957747 |
| 28 | MP0002160_abnormal_reproductive_system | 1.51838058 |
| 29 | MP0005389_reproductive_system_phenotype | 1.45297168 |
| 30 | MP0003567_abnormal_fetal_cardiomyocyte | 1.44752000 |
| 31 | MP0001986_abnormal_taste_sensitivity | 1.44204718 |
| 32 | MP0009785_altered_susceptibility_to | 1.43789578 |
| 33 | MP0004885_abnormal_endolymph | 1.42591837 |
| 34 | MP0003646_muscle_fatigue | 1.41677389 |
| 35 | MP0008995_early_reproductive_senescence | 1.38129162 |
| 36 | MP0003787_abnormal_imprinting | 1.33841987 |
| 37 | MP0008875_abnormal_xenobiotic_pharmacok | 1.33587797 |
| 38 | MP0002132_abnormal_respiratory_system | 1.33112694 |
| 39 | MP0003123_paternal_imprinting | 1.29496299 |
| 40 | MP0001293_anophthalmia | 1.28359780 |
| 41 | MP0008789_abnormal_olfactory_epithelium | 1.27099901 |
| 42 | MP0004145_abnormal_muscle_electrophysio | 1.26952400 |
| 43 | MP0001485_abnormal_pinna_reflex | 1.26416564 |
| 44 | MP0001873_stomach_inflammation | 1.24574936 |
| 45 | MP0003186_abnormal_redox_activity | 1.24068207 |
| 46 | MP0003763_abnormal_thymus_physiology | 1.23844718 |
| 47 | MP0002736_abnormal_nociception_after | 1.22172610 |
| 48 | MP0002148_abnormal_hypersensitivity_rea | 1.21160570 |
| 49 | MP0006036_abnormal_mitochondrial_physio | 1.18272142 |
| 50 | MP0002277_abnormal_respiratory_mucosa | 1.18100666 |
| 51 | MP0001919_abnormal_reproductive_system | 1.17910515 |
| 52 | MP0003195_calcinosis | 1.16996780 |
| 53 | MP0001188_hyperpigmentation | 1.16012668 |
| 54 | MP0005377_hearing/vestibular/ear_phenot | 1.14015025 |
| 55 | MP0003878_abnormal_ear_physiology | 1.14015025 |
| 56 | MP0001800_abnormal_humoral_immune | 1.12703760 |
| 57 | MP0002938_white_spotting | 1.12048325 |
| 58 | MP0002095_abnormal_skin_pigmentation | 1.11439859 |
| 59 | MP0000678_abnormal_parathyroid_gland | 1.08624398 |
| 60 | MP0001661_extended_life_span | 1.05561076 |
| 61 | MP0002420_abnormal_adaptive_immunity | 1.04721245 |
| 62 | MP0005636_abnormal_mineral_homeostasis | 1.03698374 |
| 63 | MP0004957_abnormal_blastocyst_morpholog | 1.03533579 |
| 64 | MP0001790_abnormal_immune_system | 1.03409853 |
| 65 | MP0005387_immune_system_phenotype | 1.03409853 |
| 66 | MP0002210_abnormal_sex_determination | 1.03134743 |
| 67 | MP0002638_abnormal_pupillary_reflex | 1.01121695 |
| 68 | MP0001819_abnormal_immune_cell | 1.01016285 |
| 69 | MP0010094_abnormal_chromosome_stability | 0.98976801 |
| 70 | MP0004142_abnormal_muscle_tone | 0.98728129 |
| 71 | MP0000631_abnormal_neuroendocrine_gland | 0.97951161 |
| 72 | MP0003252_abnormal_bile_duct | 0.97670066 |
| 73 | MP0005000_abnormal_immune_tolerance | 0.96839125 |
| 74 | MP0002723_abnormal_immune_serum | 0.96749094 |
| 75 | MP0002398_abnormal_bone_marrow | 0.95761634 |
| 76 | MP0001529_abnormal_vocalization | 0.92993977 |
| 77 | MP0001905_abnormal_dopamine_level | 0.92271111 |
| 78 | MP0001929_abnormal_gametogenesis | 0.90577239 |
| 79 | MP0003136_yellow_coat_color | 0.89830699 |
| 80 | MP0006276_abnormal_autonomic_nervous | 0.89744950 |
| 81 | MP0000716_abnormal_immune_system | 0.88834256 |
| 82 | MP0002234_abnormal_pharynx_morphology | 0.88334712 |
| 83 | MP0000049_abnormal_middle_ear | 0.87451017 |
| 84 | MP0005253_abnormal_eye_physiology | 0.86984792 |
| 85 | MP0000653_abnormal_sex_gland | 0.86351027 |
| 86 | MP0002693_abnormal_pancreas_physiology | 0.86214130 |
| 87 | MP0008007_abnormal_cellular_replicative | 0.85391279 |
| 88 | MP0000689_abnormal_spleen_morphology | 0.85195248 |
| 89 | MP0001145_abnormal_male_reproductive | 0.84618519 |
| 90 | MP0003718_maternal_effect | 0.82537766 |
| 91 | MP0009697_abnormal_copulation | 0.82251469 |
| 92 | MP0005410_abnormal_fertilization | 0.81046402 |
| 93 | MP0001119_abnormal_female_reproductive | 0.80324352 |
| 94 | MP0000703_abnormal_thymus_morphology | 0.79995441 |
| 95 | MP0000613_abnormal_salivary_gland | 0.79056772 |
| 96 | MP0005025_abnormal_response_to | 0.77244652 |
| 97 | MP0002429_abnormal_blood_cell | 0.76997372 |
| 98 | MP0002006_tumorigenesis | 0.75676652 |
| 99 | MP0005083_abnormal_biliary_tract | 0.74168453 |
| 100 | MP0003880_abnormal_central_pattern | 0.73990492 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.31648707 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.21226582 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.97418686 |
| 4 | Increased CSF lactate (HP:0002490) | 3.91281969 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 3.81140438 |
| 6 | Acute encephalopathy (HP:0006846) | 3.71298125 |
| 7 | Aplastic anemia (HP:0001915) | 3.53559165 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.47433917 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 3.46999834 |
| 10 | Congenital stationary night blindness (HP:0007642) | 3.41969449 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.33865200 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.30788386 |
| 13 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.30027288 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 3.29195177 |
| 15 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.21129914 |
| 16 | Hepatic necrosis (HP:0002605) | 3.18290676 |
| 17 | Reticulocytopenia (HP:0001896) | 3.16173602 |
| 18 | Increased intramyocellular lipid droplets (HP:0012240) | 3.09382880 |
| 19 | Cerebral edema (HP:0002181) | 3.03836075 |
| 20 | Increased serum lactate (HP:0002151) | 3.03049933 |
| 21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.96732044 |
| 22 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.79649197 |
| 23 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.76585966 |
| 24 | Hyperglycinemia (HP:0002154) | 2.73751044 |
| 25 | Abolished electroretinogram (ERG) (HP:0000550) | 2.69631148 |
| 26 | Lactic acidosis (HP:0003128) | 2.68115376 |
| 27 | Pancreatic cysts (HP:0001737) | 2.67262291 |
| 28 | Constricted visual fields (HP:0001133) | 2.66861034 |
| 29 | Pancreatic fibrosis (HP:0100732) | 2.62154575 |
| 30 | Optic disc pallor (HP:0000543) | 2.61650916 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 2.58105812 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.54816006 |
| 33 | Severe combined immunodeficiency (HP:0004430) | 2.53801097 |
| 34 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.50803184 |
| 35 | Pancytopenia (HP:0001876) | 2.49026267 |
| 36 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.48299919 |
| 37 | Exertional dyspnea (HP:0002875) | 2.46327354 |
| 38 | Abnormality of midbrain morphology (HP:0002418) | 2.46207389 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.46207389 |
| 40 | Macrocytic anemia (HP:0001972) | 2.45689291 |
| 41 | IgG deficiency (HP:0004315) | 2.40627068 |
| 42 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.39830270 |
| 43 | True hermaphroditism (HP:0010459) | 2.39392963 |
| 44 | Attenuation of retinal blood vessels (HP:0007843) | 2.38821690 |
| 45 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.36668209 |
| 46 | Abnormality of alanine metabolism (HP:0010916) | 2.36668209 |
| 47 | Hyperalaninemia (HP:0003348) | 2.36668209 |
| 48 | Asplenia (HP:0001746) | 2.34309348 |
| 49 | Hypoproteinemia (HP:0003075) | 2.32844069 |
| 50 | Colon cancer (HP:0003003) | 2.32102344 |
| 51 | Abnormality of B cell number (HP:0010975) | 2.31289739 |
| 52 | Respiratory difficulties (HP:0002880) | 2.31066982 |
| 53 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.29203595 |
| 54 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.29203595 |
| 55 | Methylmalonic acidemia (HP:0002912) | 2.29088082 |
| 56 | Abnormality of urine glucose concentration (HP:0011016) | 2.27629853 |
| 57 | Glycosuria (HP:0003076) | 2.27629853 |
| 58 | Lethargy (HP:0001254) | 2.25967222 |
| 59 | Absent thumb (HP:0009777) | 2.24910809 |
| 60 | B lymphocytopenia (HP:0010976) | 2.19997705 |
| 61 | Medial flaring of the eyebrow (HP:0010747) | 2.18834633 |
| 62 | Exercise intolerance (HP:0003546) | 2.14636905 |
| 63 | Type II lissencephaly (HP:0007260) | 2.13210020 |
| 64 | Methylmalonic aciduria (HP:0012120) | 2.08665357 |
| 65 | Generalized aminoaciduria (HP:0002909) | 2.08630904 |
| 66 | Respiratory failure (HP:0002878) | 2.07778661 |
| 67 | Abnormality of renal resorption (HP:0011038) | 2.02051130 |
| 68 | Hypoplasia of the uterus (HP:0000013) | 1.99725833 |
| 69 | Type 2 muscle fiber atrophy (HP:0003554) | 1.95153413 |
| 70 | Reduced antithrombin III activity (HP:0001976) | 1.94866745 |
| 71 | Abnormality of the ileum (HP:0001549) | 1.94319904 |
| 72 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93945809 |
| 73 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.91670198 |
| 74 | Dicarboxylic aciduria (HP:0003215) | 1.91670198 |
| 75 | Pallor (HP:0000980) | 1.91607862 |
| 76 | Type I transferrin isoform profile (HP:0003642) | 1.90770789 |
| 77 | Combined immunodeficiency (HP:0005387) | 1.88391966 |
| 78 | Microretrognathia (HP:0000308) | 1.86902623 |
| 79 | Meckel diverticulum (HP:0002245) | 1.86833629 |
| 80 | Abnormal protein glycosylation (HP:0012346) | 1.85468191 |
| 81 | Abnormal glycosylation (HP:0012345) | 1.85468191 |
| 82 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.85468191 |
| 83 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.85468191 |
| 84 | Abnormality of the prostate (HP:0008775) | 1.85186824 |
| 85 | Pendular nystagmus (HP:0012043) | 1.84678045 |
| 86 | Hyperphosphaturia (HP:0003109) | 1.83051787 |
| 87 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.81298844 |
| 88 | T lymphocytopenia (HP:0005403) | 1.81083833 |
| 89 | Thyroiditis (HP:0100646) | 1.80859906 |
| 90 | Decreased central vision (HP:0007663) | 1.80681932 |
| 91 | Ketosis (HP:0001946) | 1.80297055 |
| 92 | Muscle fiber atrophy (HP:0100295) | 1.79490007 |
| 93 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.79322603 |
| 94 | Abnormality of serum amino acid levels (HP:0003112) | 1.78571896 |
| 95 | Sclerocornea (HP:0000647) | 1.76878137 |
| 96 | Nephronophthisis (HP:0000090) | 1.76044719 |
| 97 | Abnormality of T cell number (HP:0011839) | 1.74886279 |
| 98 | Triphalangeal thumb (HP:0001199) | 1.74546638 |
| 99 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.72661908 |
| 100 | Abnormality of the renal cortex (HP:0011035) | 1.71693948 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.94476112 |
| 2 | BCKDK | 3.60299630 |
| 3 | TESK2 | 3.44157143 |
| 4 | KDR | 3.29599058 |
| 5 | TXK | 2.90434365 |
| 6 | ZAK | 2.88671148 |
| 7 | ADRBK2 | 2.57121311 |
| 8 | NUAK1 | 2.53461202 |
| 9 | STK16 | 2.36686306 |
| 10 | GRK1 | 2.34799755 |
| 11 | MAP4K2 | 2.26247944 |
| 12 | VRK1 | 2.04546280 |
| 13 | MAP4K1 | 2.04304804 |
| 14 | CDK19 | 1.98849804 |
| 15 | BMPR1B | 1.97092358 |
| 16 | MST4 | 1.95756947 |
| 17 | CDC7 | 1.71330815 |
| 18 | TLK1 | 1.69069955 |
| 19 | BUB1 | 1.64705978 |
| 20 | TAOK3 | 1.61826951 |
| 21 | TAF1 | 1.56999426 |
| 22 | PBK | 1.44110712 |
| 23 | PINK1 | 1.36686248 |
| 24 | WNK4 | 1.33262267 |
| 25 | EIF2AK3 | 1.31922660 |
| 26 | DYRK2 | 1.30538284 |
| 27 | TEC | 1.30339153 |
| 28 | NME2 | 1.29177253 |
| 29 | KIT | 1.25177786 |
| 30 | FRK | 1.24106079 |
| 31 | ITK | 1.22590957 |
| 32 | TIE1 | 1.20092845 |
| 33 | MAP3K12 | 1.15309543 |
| 34 | WNK3 | 1.09690235 |
| 35 | PLK4 | 1.09567089 |
| 36 | TGFBR1 | 1.08530856 |
| 37 | PASK | 1.07601965 |
| 38 | PRKCQ | 1.03749038 |
| 39 | NEK2 | 1.00014860 |
| 40 | SYK | 0.95777603 |
| 41 | NEK1 | 0.95369885 |
| 42 | EIF2AK1 | 0.95311172 |
| 43 | ACVR1B | 0.89801572 |
| 44 | DAPK1 | 0.88763663 |
| 45 | INSRR | 0.88348240 |
| 46 | MUSK | 0.87845871 |
| 47 | TNK2 | 0.84091018 |
| 48 | LIMK1 | 0.83979665 |
| 49 | PLK3 | 0.83225757 |
| 50 | CCNB1 | 0.82366030 |
| 51 | RPS6KA4 | 0.79410355 |
| 52 | ADRBK1 | 0.75340348 |
| 53 | PLK1 | 0.75311421 |
| 54 | CDK8 | 0.72733559 |
| 55 | CSNK1G1 | 0.69057678 |
| 56 | ATR | 0.69023844 |
| 57 | IKBKB | 0.68963791 |
| 58 | RPS6KA5 | 0.68095726 |
| 59 | STK39 | 0.68093341 |
| 60 | LRRK2 | 0.67694059 |
| 61 | OXSR1 | 0.65385973 |
| 62 | AURKA | 0.64527853 |
| 63 | BTK | 0.58591218 |
| 64 | LCK | 0.56658071 |
| 65 | AURKB | 0.56252948 |
| 66 | GRK6 | 0.56071502 |
| 67 | CSNK2A2 | 0.54007441 |
| 68 | CSNK2A1 | 0.53475188 |
| 69 | CSNK1G3 | 0.52646843 |
| 70 | MAP3K11 | 0.50008986 |
| 71 | NME1 | 0.48689422 |
| 72 | ABL2 | 0.47785729 |
| 73 | LYN | 0.46414201 |
| 74 | TNIK | 0.43329856 |
| 75 | RPS6KB2 | 0.43278639 |
| 76 | CAMK1 | 0.42943360 |
| 77 | PLK2 | 0.42393883 |
| 78 | SCYL2 | 0.42119936 |
| 79 | PRKCH | 0.41877373 |
| 80 | MAP2K7 | 0.41589512 |
| 81 | FLT3 | 0.41149908 |
| 82 | DAPK3 | 0.40805314 |
| 83 | PRKCG | 0.40773200 |
| 84 | GRK5 | 0.40433071 |
| 85 | PRKCE | 0.40283376 |
| 86 | CHEK2 | 0.39803012 |
| 87 | MYLK | 0.39664356 |
| 88 | CSF1R | 0.39023566 |
| 89 | CAMKK2 | 0.38841082 |
| 90 | PIM2 | 0.38394923 |
| 91 | PIM1 | 0.37519387 |
| 92 | CSNK1G2 | 0.37231774 |
| 93 | CSNK1A1 | 0.36994230 |
| 94 | GRK7 | 0.36860218 |
| 95 | PRKCI | 0.35791952 |
| 96 | PRKACA | 0.35109655 |
| 97 | EIF2AK2 | 0.35069926 |
| 98 | PRKCA | 0.34895947 |
| 99 | MKNK1 | 0.32806753 |
| 100 | MAPKAPK3 | 0.32092405 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.52281252 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.87598496 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.71103240 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.16679091 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.83997649 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.70078508 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.12444763 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.05519938 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.04885346 |
| 10 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.98945866 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 1.96722285 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 1.94506079 |
| 13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.87673354 |
| 14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.83469919 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.81873856 |
| 16 | Phototransduction_Homo sapiens_hsa04744 | 1.78735596 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.70144948 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.65295178 |
| 19 | Base excision repair_Homo sapiens_hsa03410 | 1.64510774 |
| 20 | Mismatch repair_Homo sapiens_hsa03430 | 1.62608967 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.61114214 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.59963670 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57153592 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52562816 |
| 25 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.42779094 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.38192379 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.36291304 |
| 28 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.35107277 |
| 29 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.32553003 |
| 30 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.26676929 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.26090467 |
| 32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.25719338 |
| 33 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.25008916 |
| 34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.22719099 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.22449621 |
| 36 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.20624452 |
| 37 | Peroxisome_Homo sapiens_hsa04146 | 1.20291596 |
| 38 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.18937977 |
| 39 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.17778141 |
| 40 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.17523264 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.15025042 |
| 42 | Spliceosome_Homo sapiens_hsa03040 | 1.12081551 |
| 43 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.10901352 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.10284487 |
| 45 | RNA transport_Homo sapiens_hsa03013 | 1.08007888 |
| 46 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.07381332 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 1.05342245 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.03727547 |
| 49 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.98322448 |
| 50 | Asthma_Homo sapiens_hsa05310 | 0.98308133 |
| 51 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.94602327 |
| 52 | Olfactory transduction_Homo sapiens_hsa04740 | 0.88259847 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.87333334 |
| 54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.83673463 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.82611507 |
| 56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.81907430 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.81653356 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.79622239 |
| 59 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.76882308 |
| 60 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.76034947 |
| 61 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.70137904 |
| 62 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.69738058 |
| 63 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.68889204 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.66873300 |
| 65 | Retinol metabolism_Homo sapiens_hsa00830 | 0.65020226 |
| 66 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.63605373 |
| 67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.63486392 |
| 68 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.61975111 |
| 69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61032892 |
| 70 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.59325214 |
| 71 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.58492537 |
| 72 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58441119 |
| 73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.56296148 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.55807199 |
| 75 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.55206610 |
| 76 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.54495539 |
| 77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54237786 |
| 78 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.53926165 |
| 79 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.52347795 |
| 80 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.51326344 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.51195020 |
| 82 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.48424095 |
| 83 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47399212 |
| 84 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.46135673 |
| 85 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.45960409 |
| 86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.45056640 |
| 87 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32876717 |
| 88 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32104063 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.30054962 |
| 90 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.28392517 |
| 91 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.28053611 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.27647716 |
| 93 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.26176471 |
| 94 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.25036087 |
| 95 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.23997848 |
| 96 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.22178574 |
| 97 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.19933611 |
| 98 | Nicotine addiction_Homo sapiens_hsa05033 | 0.19046304 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.19017345 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.18186118 |

