RPSAP54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.13212009
2DNA deamination (GO:0045006)6.95953009
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.97286803
4cytidine catabolic process (GO:0006216)5.00490614
5cytidine deamination (GO:0009972)5.00490614
6cytidine metabolic process (GO:0046087)5.00490614
7ATP synthesis coupled proton transport (GO:0015986)4.76613942
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76613942
9chaperone-mediated protein transport (GO:0072321)4.75331369
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73091134
11viral transcription (GO:0019083)4.57648996
12ribosomal small subunit biogenesis (GO:0042274)4.48627619
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.45118272
14translational termination (GO:0006415)4.44864840
15protein complex biogenesis (GO:0070271)4.30968124
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25104421
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.25104421
18NADH dehydrogenase complex assembly (GO:0010257)4.25104421
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.22919860
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.18687481
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.18687481
22translational elongation (GO:0006414)4.13070905
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02798079
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.00844558
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99499974
26maturation of SSU-rRNA (GO:0030490)3.97616451
27mitochondrial respiratory chain complex assembly (GO:0033108)3.96767290
28cotranslational protein targeting to membrane (GO:0006613)3.92684525
29protein targeting to ER (GO:0045047)3.91830151
30proteasome assembly (GO:0043248)3.87151150
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71481271
32respiratory electron transport chain (GO:0022904)3.70827089
33protein localization to endoplasmic reticulum (GO:0070972)3.68163676
34electron transport chain (GO:0022900)3.66783105
35protein neddylation (GO:0045116)3.63773863
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63026476
37water-soluble vitamin biosynthetic process (GO:0042364)3.57388986
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51928427
39ncRNA 3-end processing (GO:0043628)3.48054139
40pseudouridine synthesis (GO:0001522)3.47244309
41GTP biosynthetic process (GO:0006183)3.44467144
42translation (GO:0006412)3.41673847
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39792128
44translational initiation (GO:0006413)3.35410812
45viral life cycle (GO:0019058)3.34507268
46rRNA modification (GO:0000154)3.32890276
47cellular protein complex disassembly (GO:0043624)3.29310565
48deoxyribonucleotide catabolic process (GO:0009264)3.28622429
49respiratory chain complex IV assembly (GO:0008535)3.28266199
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26933247
51pyrimidine nucleotide catabolic process (GO:0006244)3.25726616
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21071338
53cellular component biogenesis (GO:0044085)3.19654207
54response to pheromone (GO:0019236)3.18014605
55termination of RNA polymerase III transcription (GO:0006386)3.11956335
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.11956335
57deoxyribose phosphate catabolic process (GO:0046386)3.11613656
58base-excision repair, AP site formation (GO:0006285)3.09852195
59cytochrome complex assembly (GO:0017004)3.08723922
60behavioral response to nicotine (GO:0035095)3.03515331
61ubiquinone biosynthetic process (GO:0006744)3.03460603
62ribosomal large subunit biogenesis (GO:0042273)3.03218558
63rRNA processing (GO:0006364)3.00670170
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99674498
65UTP biosynthetic process (GO:0006228)2.99207497
66deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99115991
67ribonucleoprotein complex biogenesis (GO:0022613)2.96671888
68rRNA metabolic process (GO:0016072)2.95151514
69peptidyl-histidine modification (GO:0018202)2.93080527
70purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92994392
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90483787
72regulation of cellular amino acid metabolic process (GO:0006521)2.89410836
73protein targeting to mitochondrion (GO:0006626)2.86765349
74UTP metabolic process (GO:0046051)2.85228820
75mannosylation (GO:0097502)2.83667399
76negative regulation of telomere maintenance (GO:0032205)2.81001850
77platelet dense granule organization (GO:0060155)2.79423128
78regulation of mitochondrial translation (GO:0070129)2.76432128
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75669412
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73942737
81protein-cofactor linkage (GO:0018065)2.73812987
82ATP biosynthetic process (GO:0006754)2.73436411
83establishment of protein localization to mitochondrion (GO:0072655)2.73131235
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69551863
85pyrimidine ribonucleoside metabolic process (GO:0046131)2.69401905
86purine deoxyribonucleotide catabolic process (GO:0009155)2.69312579
87iron-sulfur cluster assembly (GO:0016226)2.67854323
88metallo-sulfur cluster assembly (GO:0031163)2.67854323
89piRNA metabolic process (GO:0034587)2.67537258
90negative regulation of ligase activity (GO:0051352)2.67514916
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67514916
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66440704
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66440704
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66440704
95protein complex disassembly (GO:0043241)2.65892937
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.65556978
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62752476
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62752476
99pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.62287618
100purine nucleotide salvage (GO:0032261)2.62047095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.04946390
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35027018
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.11505478
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.48372977
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38835342
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08055964
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.04891259
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00644447
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76870520
10VDR_22108803_ChIP-Seq_LS180_Human2.75275304
11VDR_23849224_ChIP-Seq_CD4+_Human2.64608504
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.61160305
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52035306
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.49997053
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43834523
16ZNF274_21170338_ChIP-Seq_K562_Hela2.36778798
17FOXP3_21729870_ChIP-Seq_TREG_Human2.33947283
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17168809
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10775854
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07825444
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06130168
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.03639537
23MYC_18940864_ChIP-ChIP_HL60_Human1.94927842
24ELK1_19687146_ChIP-ChIP_HELA_Human1.91305467
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83139052
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83065971
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.80273202
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69041568
29IGF1R_20145208_ChIP-Seq_DFB_Human1.65034962
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61864469
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.60740916
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58925070
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58288952
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57784659
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.54850040
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53236209
37GABP_19822575_ChIP-Seq_HepG2_Human1.51651365
38TP53_22573176_ChIP-Seq_HFKS_Human1.51381078
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49750874
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49736960
41TTF2_22483619_ChIP-Seq_HELA_Human1.48850776
42EWS_26573619_Chip-Seq_HEK293_Human1.46317384
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41859872
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40885880
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39095318
46EZH2_22144423_ChIP-Seq_EOC_Human1.37491186
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.34995344
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32682505
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32450318
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.31814945
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31814945
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29656775
53CIITA_25753668_ChIP-Seq_RAJI_Human1.28583242
54DCP1A_22483619_ChIP-Seq_HELA_Human1.27813777
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27327995
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26801739
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25091673
58NANOG_20526341_ChIP-Seq_ESCs_Human1.25009897
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24872923
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23845103
61XRN2_22483619_ChIP-Seq_HELA_Human1.22507745
62AR_20517297_ChIP-Seq_VCAP_Human1.21973702
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21809701
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17944902
65NCOR_22424771_ChIP-Seq_293T_Human1.16037157
66IRF1_19129219_ChIP-ChIP_H3396_Human1.15958284
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15786905
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14738536
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13239812
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.11373948
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.08971887
72GATA3_26560356_Chip-Seq_TH2_Human1.07236445
73TAF2_19829295_ChIP-Seq_ESCs_Human1.07145926
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05761222
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05302956
76FUS_26573619_Chip-Seq_HEK293_Human1.04555095
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02722921
78MYB_26560356_Chip-Seq_TH2_Human1.01304544
79NANOG_19829295_ChIP-Seq_ESCs_Human0.99865642
80SOX2_19829295_ChIP-Seq_ESCs_Human0.99865642
81E2F7_22180533_ChIP-Seq_HELA_Human0.99304259
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98030797
83HTT_18923047_ChIP-ChIP_STHdh_Human0.97188729
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96551613
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95833097
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94277726
87ERG_20517297_ChIP-Seq_VCAP_Human0.93381729
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92277388
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91997857
90MYC_19829295_ChIP-Seq_ESCs_Human0.90841162
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89990366
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88404706
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88380560
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88082509
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87847059
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87384481
97BCL6_27268052_Chip-Seq_Bcells_Human0.86940497
98P53_21459846_ChIP-Seq_SAOS-2_Human0.86547175
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86190474
100ERA_21632823_ChIP-Seq_H3396_Human0.85930475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.55957068
2MP0002138_abnormal_hepatobiliary_system3.28766208
3MP0009379_abnormal_foot_pigmentation3.11816392
4MP0005671_abnormal_response_to3.00765328
5MP0005646_abnormal_pituitary_gland2.59091605
6MP0008877_abnormal_DNA_methylation2.50962378
7MP0005084_abnormal_gallbladder_morpholo2.35780162
8MP0004147_increased_porphyrin_level2.25064207
9MP0003786_premature_aging2.11758110
10MP0002837_dystrophic_cardiac_calcinosis2.10868072
11MP0000372_irregular_coat_pigmentation2.08016193
12MP0002163_abnormal_gland_morphology2.02671865
13MP0009333_abnormal_splenocyte_physiolog2.02592939
14MP0008058_abnormal_DNA_repair1.91714337
15MP0006072_abnormal_retinal_apoptosis1.73498467
16MP0003806_abnormal_nucleotide_metabolis1.73022949
17MP0005645_abnormal_hypothalamus_physiol1.72299785
18MP0001835_abnormal_antigen_presentation1.71020422
19MP0008872_abnormal_physiological_respon1.67931043
20MP0005551_abnormal_eye_electrophysiolog1.67066860
21MP0002102_abnormal_ear_morphology1.65758934
22MP0002876_abnormal_thyroid_physiology1.64675598
23MP0001764_abnormal_homeostasis1.61456362
24MP0002653_abnormal_ependyma_morphology1.61085524
25MP0001968_abnormal_touch/_nociception1.58344531
26MP0005075_abnormal_melanosome_morpholog1.57826367
27MP0005379_endocrine/exocrine_gland_phen1.53957747
28MP0002160_abnormal_reproductive_system1.51838058
29MP0005389_reproductive_system_phenotype1.45297168
30MP0003567_abnormal_fetal_cardiomyocyte1.44752000
31MP0001986_abnormal_taste_sensitivity1.44204718
32MP0009785_altered_susceptibility_to1.43789578
33MP0004885_abnormal_endolymph1.42591837
34MP0003646_muscle_fatigue1.41677389
35MP0008995_early_reproductive_senescence1.38129162
36MP0003787_abnormal_imprinting1.33841987
37MP0008875_abnormal_xenobiotic_pharmacok1.33587797
38MP0002132_abnormal_respiratory_system1.33112694
39MP0003123_paternal_imprinting1.29496299
40MP0001293_anophthalmia1.28359780
41MP0008789_abnormal_olfactory_epithelium1.27099901
42MP0004145_abnormal_muscle_electrophysio1.26952400
43MP0001485_abnormal_pinna_reflex1.26416564
44MP0001873_stomach_inflammation1.24574936
45MP0003186_abnormal_redox_activity1.24068207
46MP0003763_abnormal_thymus_physiology1.23844718
47MP0002736_abnormal_nociception_after1.22172610
48MP0002148_abnormal_hypersensitivity_rea1.21160570
49MP0006036_abnormal_mitochondrial_physio1.18272142
50MP0002277_abnormal_respiratory_mucosa1.18100666
51MP0001919_abnormal_reproductive_system1.17910515
52MP0003195_calcinosis1.16996780
53MP0001188_hyperpigmentation1.16012668
54MP0005377_hearing/vestibular/ear_phenot1.14015025
55MP0003878_abnormal_ear_physiology1.14015025
56MP0001800_abnormal_humoral_immune1.12703760
57MP0002938_white_spotting1.12048325
58MP0002095_abnormal_skin_pigmentation1.11439859
59MP0000678_abnormal_parathyroid_gland1.08624398
60MP0001661_extended_life_span1.05561076
61MP0002420_abnormal_adaptive_immunity1.04721245
62MP0005636_abnormal_mineral_homeostasis1.03698374
63MP0004957_abnormal_blastocyst_morpholog1.03533579
64MP0001790_abnormal_immune_system1.03409853
65MP0005387_immune_system_phenotype1.03409853
66MP0002210_abnormal_sex_determination1.03134743
67MP0002638_abnormal_pupillary_reflex1.01121695
68MP0001819_abnormal_immune_cell1.01016285
69MP0010094_abnormal_chromosome_stability0.98976801
70MP0004142_abnormal_muscle_tone0.98728129
71MP0000631_abnormal_neuroendocrine_gland0.97951161
72MP0003252_abnormal_bile_duct0.97670066
73MP0005000_abnormal_immune_tolerance0.96839125
74MP0002723_abnormal_immune_serum0.96749094
75MP0002398_abnormal_bone_marrow0.95761634
76MP0001529_abnormal_vocalization0.92993977
77MP0001905_abnormal_dopamine_level0.92271111
78MP0001929_abnormal_gametogenesis0.90577239
79MP0003136_yellow_coat_color0.89830699
80MP0006276_abnormal_autonomic_nervous0.89744950
81MP0000716_abnormal_immune_system0.88834256
82MP0002234_abnormal_pharynx_morphology0.88334712
83MP0000049_abnormal_middle_ear0.87451017
84MP0005253_abnormal_eye_physiology0.86984792
85MP0000653_abnormal_sex_gland0.86351027
86MP0002693_abnormal_pancreas_physiology0.86214130
87MP0008007_abnormal_cellular_replicative0.85391279
88MP0000689_abnormal_spleen_morphology0.85195248
89MP0001145_abnormal_male_reproductive0.84618519
90MP0003718_maternal_effect0.82537766
91MP0009697_abnormal_copulation0.82251469
92MP0005410_abnormal_fertilization0.81046402
93MP0001119_abnormal_female_reproductive0.80324352
94MP0000703_abnormal_thymus_morphology0.79995441
95MP0000613_abnormal_salivary_gland0.79056772
96MP0005025_abnormal_response_to0.77244652
97MP0002429_abnormal_blood_cell0.76997372
98MP0002006_tumorigenesis0.75676652
99MP0005083_abnormal_biliary_tract0.74168453
100MP0003880_abnormal_central_pattern0.73990492

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.31648707
2Mitochondrial inheritance (HP:0001427)4.21226582
3Abnormal mitochondria in muscle tissue (HP:0008316)3.97418686
4Increased CSF lactate (HP:0002490)3.91281969
5Increased hepatocellular lipid droplets (HP:0006565)3.81140438
6Acute encephalopathy (HP:0006846)3.71298125
7Aplastic anemia (HP:0001915)3.53559165
8Progressive macrocephaly (HP:0004481)3.47433917
9Lipid accumulation in hepatocytes (HP:0006561)3.46999834
10Congenital stationary night blindness (HP:0007642)3.41969449
11Hepatocellular necrosis (HP:0001404)3.33865200
123-Methylglutaconic aciduria (HP:0003535)3.30788386
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.30027288
14Renal Fanconi syndrome (HP:0001994)3.29195177
15Abnormal rod and cone electroretinograms (HP:0008323)3.21129914
16Hepatic necrosis (HP:0002605)3.18290676
17Reticulocytopenia (HP:0001896)3.16173602
18Increased intramyocellular lipid droplets (HP:0012240)3.09382880
19Cerebral edema (HP:0002181)3.03836075
20Increased serum lactate (HP:0002151)3.03049933
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96732044
22Elevated erythrocyte sedimentation rate (HP:0003565)2.79649197
23Abnormality of cells of the erythroid lineage (HP:0012130)2.76585966
24Hyperglycinemia (HP:0002154)2.73751044
25Abolished electroretinogram (ERG) (HP:0000550)2.69631148
26Lactic acidosis (HP:0003128)2.68115376
27Pancreatic cysts (HP:0001737)2.67262291
28Constricted visual fields (HP:0001133)2.66861034
29Pancreatic fibrosis (HP:0100732)2.62154575
30Optic disc pallor (HP:0000543)2.61650916
31Abnormal number of erythroid precursors (HP:0012131)2.58105812
32Increased muscle lipid content (HP:0009058)2.54816006
33Severe combined immunodeficiency (HP:0004430)2.53801097
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50803184
35Pancytopenia (HP:0001876)2.49026267
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48299919
37Exertional dyspnea (HP:0002875)2.46327354
38Abnormality of midbrain morphology (HP:0002418)2.46207389
39Molar tooth sign on MRI (HP:0002419)2.46207389
40Macrocytic anemia (HP:0001972)2.45689291
41IgG deficiency (HP:0004315)2.40627068
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.39830270
43True hermaphroditism (HP:0010459)2.39392963
44Attenuation of retinal blood vessels (HP:0007843)2.38821690
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36668209
46Abnormality of alanine metabolism (HP:0010916)2.36668209
47Hyperalaninemia (HP:0003348)2.36668209
48Asplenia (HP:0001746)2.34309348
49Hypoproteinemia (HP:0003075)2.32844069
50Colon cancer (HP:0003003)2.32102344
51Abnormality of B cell number (HP:0010975)2.31289739
52Respiratory difficulties (HP:0002880)2.31066982
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29203595
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29203595
55Methylmalonic acidemia (HP:0002912)2.29088082
56Abnormality of urine glucose concentration (HP:0011016)2.27629853
57Glycosuria (HP:0003076)2.27629853
58Lethargy (HP:0001254)2.25967222
59Absent thumb (HP:0009777)2.24910809
60B lymphocytopenia (HP:0010976)2.19997705
61Medial flaring of the eyebrow (HP:0010747)2.18834633
62Exercise intolerance (HP:0003546)2.14636905
63Type II lissencephaly (HP:0007260)2.13210020
64Methylmalonic aciduria (HP:0012120)2.08665357
65Generalized aminoaciduria (HP:0002909)2.08630904
66Respiratory failure (HP:0002878)2.07778661
67Abnormality of renal resorption (HP:0011038)2.02051130
68Hypoplasia of the uterus (HP:0000013)1.99725833
69Type 2 muscle fiber atrophy (HP:0003554)1.95153413
70Reduced antithrombin III activity (HP:0001976)1.94866745
71Abnormality of the ileum (HP:0001549)1.94319904
72Aplasia/hypoplasia of the uterus (HP:0008684)1.93945809
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91670198
74Dicarboxylic aciduria (HP:0003215)1.91670198
75Pallor (HP:0000980)1.91607862
76Type I transferrin isoform profile (HP:0003642)1.90770789
77Combined immunodeficiency (HP:0005387)1.88391966
78Microretrognathia (HP:0000308)1.86902623
79Meckel diverticulum (HP:0002245)1.86833629
80Abnormal protein glycosylation (HP:0012346)1.85468191
81Abnormal glycosylation (HP:0012345)1.85468191
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85468191
83Abnormal protein N-linked glycosylation (HP:0012347)1.85468191
84Abnormality of the prostate (HP:0008775)1.85186824
85Pendular nystagmus (HP:0012043)1.84678045
86Hyperphosphaturia (HP:0003109)1.83051787
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81298844
88T lymphocytopenia (HP:0005403)1.81083833
89Thyroiditis (HP:0100646)1.80859906
90Decreased central vision (HP:0007663)1.80681932
91Ketosis (HP:0001946)1.80297055
92Muscle fiber atrophy (HP:0100295)1.79490007
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.79322603
94Abnormality of serum amino acid levels (HP:0003112)1.78571896
95Sclerocornea (HP:0000647)1.76878137
96Nephronophthisis (HP:0000090)1.76044719
97Abnormality of T cell number (HP:0011839)1.74886279
98Triphalangeal thumb (HP:0001199)1.74546638
99Abnormality of the phalanges of the 5th finger (HP:0004213)1.72661908
100Abnormality of the renal cortex (HP:0011035)1.71693948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.94476112
2BCKDK3.60299630
3TESK23.44157143
4KDR3.29599058
5TXK2.90434365
6ZAK2.88671148
7ADRBK22.57121311
8NUAK12.53461202
9STK162.36686306
10GRK12.34799755
11MAP4K22.26247944
12VRK12.04546280
13MAP4K12.04304804
14CDK191.98849804
15BMPR1B1.97092358
16MST41.95756947
17CDC71.71330815
18TLK11.69069955
19BUB11.64705978
20TAOK31.61826951
21TAF11.56999426
22PBK1.44110712
23PINK11.36686248
24WNK41.33262267
25EIF2AK31.31922660
26DYRK21.30538284
27TEC1.30339153
28NME21.29177253
29KIT1.25177786
30FRK1.24106079
31ITK1.22590957
32TIE11.20092845
33MAP3K121.15309543
34WNK31.09690235
35PLK41.09567089
36TGFBR11.08530856
37PASK1.07601965
38PRKCQ1.03749038
39NEK21.00014860
40SYK0.95777603
41NEK10.95369885
42EIF2AK10.95311172
43ACVR1B0.89801572
44DAPK10.88763663
45INSRR0.88348240
46MUSK0.87845871
47TNK20.84091018
48LIMK10.83979665
49PLK30.83225757
50CCNB10.82366030
51RPS6KA40.79410355
52ADRBK10.75340348
53PLK10.75311421
54CDK80.72733559
55CSNK1G10.69057678
56ATR0.69023844
57IKBKB0.68963791
58RPS6KA50.68095726
59STK390.68093341
60LRRK20.67694059
61OXSR10.65385973
62AURKA0.64527853
63BTK0.58591218
64LCK0.56658071
65AURKB0.56252948
66GRK60.56071502
67CSNK2A20.54007441
68CSNK2A10.53475188
69CSNK1G30.52646843
70MAP3K110.50008986
71NME10.48689422
72ABL20.47785729
73LYN0.46414201
74TNIK0.43329856
75RPS6KB20.43278639
76CAMK10.42943360
77PLK20.42393883
78SCYL20.42119936
79PRKCH0.41877373
80MAP2K70.41589512
81FLT30.41149908
82DAPK30.40805314
83PRKCG0.40773200
84GRK50.40433071
85PRKCE0.40283376
86CHEK20.39803012
87MYLK0.39664356
88CSF1R0.39023566
89CAMKK20.38841082
90PIM20.38394923
91PIM10.37519387
92CSNK1G20.37231774
93CSNK1A10.36994230
94GRK70.36860218
95PRKCI0.35791952
96PRKACA0.35109655
97EIF2AK20.35069926
98PRKCA0.34895947
99MKNK10.32806753
100MAPKAPK30.32092405

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.52281252
2Proteasome_Homo sapiens_hsa030503.87598496
3Oxidative phosphorylation_Homo sapiens_hsa001903.71103240
4Parkinsons disease_Homo sapiens_hsa050123.16679091
5RNA polymerase_Homo sapiens_hsa030202.83997649
6Primary immunodeficiency_Homo sapiens_hsa053402.70078508
7Huntingtons disease_Homo sapiens_hsa050162.12444763
8Homologous recombination_Homo sapiens_hsa034402.05519938
9Protein export_Homo sapiens_hsa030602.04885346
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98945866
11Alzheimers disease_Homo sapiens_hsa050101.96722285
12DNA replication_Homo sapiens_hsa030301.94506079
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87673354
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83469919
15Pyrimidine metabolism_Homo sapiens_hsa002401.81873856
16Phototransduction_Homo sapiens_hsa047441.78735596
17RNA degradation_Homo sapiens_hsa030181.70144948
18Fanconi anemia pathway_Homo sapiens_hsa034601.65295178
19Base excision repair_Homo sapiens_hsa034101.64510774
20Mismatch repair_Homo sapiens_hsa034301.62608967
21One carbon pool by folate_Homo sapiens_hsa006701.61114214
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59963670
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57153592
24Basal transcription factors_Homo sapiens_hsa030221.52562816
25Cardiac muscle contraction_Homo sapiens_hsa042601.42779094
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38192379
27Allograft rejection_Homo sapiens_hsa053301.36291304
28Linoleic acid metabolism_Homo sapiens_hsa005911.35107277
29Graft-versus-host disease_Homo sapiens_hsa053321.32553003
30Caffeine metabolism_Homo sapiens_hsa002321.26676929
31Purine metabolism_Homo sapiens_hsa002301.26090467
32Autoimmune thyroid disease_Homo sapiens_hsa053201.25719338
33Nitrogen metabolism_Homo sapiens_hsa009101.25008916
34Antigen processing and presentation_Homo sapiens_hsa046121.22719099
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22449621
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20624452
37Peroxisome_Homo sapiens_hsa041461.20291596
38Nucleotide excision repair_Homo sapiens_hsa034201.18937977
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.17778141
40Type I diabetes mellitus_Homo sapiens_hsa049401.17523264
41Propanoate metabolism_Homo sapiens_hsa006401.15025042
42Spliceosome_Homo sapiens_hsa030401.12081551
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10901352
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.10284487
45RNA transport_Homo sapiens_hsa030131.08007888
46Butanoate metabolism_Homo sapiens_hsa006501.07381332
47Sulfur relay system_Homo sapiens_hsa041221.05342245
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03727547
49Hematopoietic cell lineage_Homo sapiens_hsa046400.98322448
50Asthma_Homo sapiens_hsa053100.98308133
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94602327
52Olfactory transduction_Homo sapiens_hsa047400.88259847
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87333334
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83673463
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82611507
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81907430
57Metabolic pathways_Homo sapiens_hsa011000.81653356
58Tryptophan metabolism_Homo sapiens_hsa003800.79622239
59Folate biosynthesis_Homo sapiens_hsa007900.76882308
60Ether lipid metabolism_Homo sapiens_hsa005650.76034947
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.70137904
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69738058
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.68889204
64Arachidonic acid metabolism_Homo sapiens_hsa005900.66873300
65Retinol metabolism_Homo sapiens_hsa008300.65020226
66Sulfur metabolism_Homo sapiens_hsa009200.63605373
67Chemical carcinogenesis_Homo sapiens_hsa052040.63486392
68Non-homologous end-joining_Homo sapiens_hsa034500.61975111
69Glutathione metabolism_Homo sapiens_hsa004800.61032892
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59325214
71Fatty acid elongation_Homo sapiens_hsa000620.58492537
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58441119
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56296148
74Steroid biosynthesis_Homo sapiens_hsa001000.55807199
75Rheumatoid arthritis_Homo sapiens_hsa053230.55206610
76Selenocompound metabolism_Homo sapiens_hsa004500.54495539
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54237786
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53926165
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.52347795
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.51326344
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51195020
82T cell receptor signaling pathway_Homo sapiens_hsa046600.48424095
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47399212
84Pyruvate metabolism_Homo sapiens_hsa006200.46135673
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45960409
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45056640
87Regulation of autophagy_Homo sapiens_hsa041400.32876717
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32104063
89Fatty acid degradation_Homo sapiens_hsa000710.30054962
90Collecting duct acid secretion_Homo sapiens_hsa049660.28392517
91Fat digestion and absorption_Homo sapiens_hsa049750.28053611
92Taste transduction_Homo sapiens_hsa047420.27647716
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26176471
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25036087
95Ovarian steroidogenesis_Homo sapiens_hsa049130.23997848
96mRNA surveillance pathway_Homo sapiens_hsa030150.22178574
97Systemic lupus erythematosus_Homo sapiens_hsa053220.19933611
98Nicotine addiction_Homo sapiens_hsa050330.19046304
99Epstein-Barr virus infection_Homo sapiens_hsa051690.19017345
100beta-Alanine metabolism_Homo sapiens_hsa004100.18186118

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