RPSAP55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.02799111
2viral transcription (GO:0019083)7.39638589
3translational termination (GO:0006415)7.12239344
4ribosomal small subunit biogenesis (GO:0042274)6.56257787
5maturation of SSU-rRNA (GO:0030490)6.39958876
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.94459351
7cotranslational protein targeting to membrane (GO:0006613)5.93686966
8protein targeting to ER (GO:0045047)5.88827202
9translational elongation (GO:0006414)5.88327247
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.67174091
11protein localization to endoplasmic reticulum (GO:0070972)5.52125560
12cellular protein complex disassembly (GO:0043624)5.41955275
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.34614677
14viral life cycle (GO:0019058)5.27858348
15protein complex disassembly (GO:0043241)4.65596467
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.64063194
17ATP synthesis coupled proton transport (GO:0015986)4.58465603
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58465603
19translational initiation (GO:0006413)4.54478233
20macromolecular complex disassembly (GO:0032984)4.39366728
21protein neddylation (GO:0045116)4.34613452
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26183955
23behavioral response to nicotine (GO:0035095)4.21643950
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.20856034
25ribosomal large subunit biogenesis (GO:0042273)4.16824683
26chaperone-mediated protein transport (GO:0072321)4.09386445
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94344172
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.90269995
29substrate-independent telencephalic tangential migration (GO:0021826)3.90269995
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.88977922
31NADH dehydrogenase complex assembly (GO:0010257)3.88977922
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88977922
33protein targeting to membrane (GO:0006612)3.86456564
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.80001886
35translation (GO:0006412)3.75800247
36pyrimidine nucleotide catabolic process (GO:0006244)3.71229904
37mRNA catabolic process (GO:0006402)3.59049268
38protein complex biogenesis (GO:0070271)3.54045693
39hypothalamus development (GO:0021854)3.50574940
40regulation of cilium movement (GO:0003352)3.48998532
41GTP biosynthetic process (GO:0006183)3.48674941
42base-excision repair, AP site formation (GO:0006285)3.45229987
43positive regulation of protein homooligomerization (GO:0032464)3.43302933
44negative regulation of appetite (GO:0032099)3.42528141
45negative regulation of response to food (GO:0032096)3.42528141
46ribonucleoprotein complex biogenesis (GO:0022613)3.40168248
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32899853
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32371437
49cellular component biogenesis (GO:0044085)3.30035274
50nonmotile primary cilium assembly (GO:0035058)3.27162402
51RNA catabolic process (GO:0006401)3.26284180
52cell proliferation in forebrain (GO:0021846)3.26107171
53respiratory electron transport chain (GO:0022904)3.25987928
54electron transport chain (GO:0022900)3.24417577
55mitochondrial respiratory chain complex assembly (GO:0033108)3.22566408
56UTP biosynthetic process (GO:0006228)3.19062755
57axon ensheathment in central nervous system (GO:0032291)3.15888679
58central nervous system myelination (GO:0022010)3.15888679
59myoblast migration (GO:0051451)3.14174898
60neuron fate determination (GO:0048664)3.13637660
61CTP biosynthetic process (GO:0006241)3.07321743
62CTP metabolic process (GO:0046036)3.07321743
63regulation of cellular respiration (GO:0043457)3.06088668
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02685157
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02685157
66pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99655204
67positive regulation of growth hormone secretion (GO:0060124)2.96098253
68UTP metabolic process (GO:0046051)2.93167329
69heterochromatin organization (GO:0070828)2.90990613
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90245430
71brain morphogenesis (GO:0048854)2.89473468
72DNA deamination (GO:0045006)2.88998883
73pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88232564
74parturition (GO:0007567)2.85275026
75somite development (GO:0061053)2.83819990
76rRNA processing (GO:0006364)2.82614482
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82267127
78segment specification (GO:0007379)2.82051986
79pattern specification involved in kidney development (GO:0061004)2.79760209
80rRNA metabolic process (GO:0016072)2.79311770
81regulation of microtubule-based movement (GO:0060632)2.77282265
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72154325
83pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.70774366
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69354897
85ncRNA 3-end processing (GO:0043628)2.69097453
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66147431
87regulation of non-canonical Wnt signaling pathway (GO:2000050)2.65295832
88positive regulation of cellular response to oxidative stress (GO:1900409)2.61052857
89positive regulation of response to oxidative stress (GO:1902884)2.61052857
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60925056
91resolution of meiotic recombination intermediates (GO:0000712)2.60540578
92regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60061056
93telencephalon development (GO:0021537)2.57163354
94lactate metabolic process (GO:0006089)2.56397091
95forebrain morphogenesis (GO:0048853)2.56373743
96isoprenoid biosynthetic process (GO:0008299)2.56348899
97protein targeting (GO:0006605)2.56330642
98establishment of protein localization to membrane (GO:0090150)2.55249296
99negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52063779
100tongue development (GO:0043586)2.52043295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99437208
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62271845
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.53285963
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42965070
5IRF1_19129219_ChIP-ChIP_H3396_Human3.06537752
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99170113
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.86760654
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81411319
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.77606262
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.71973355
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49029213
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34158112
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18753001
14ZNF274_21170338_ChIP-Seq_K562_Hela2.06774500
15VDR_22108803_ChIP-Seq_LS180_Human2.04202846
16MYC_18940864_ChIP-ChIP_HL60_Human2.00772900
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98722955
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91566865
19TTF2_22483619_ChIP-Seq_HELA_Human1.89924500
20FOXP3_21729870_ChIP-Seq_TREG_Human1.85142704
21VDR_23849224_ChIP-Seq_CD4+_Human1.82285489
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79303396
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77465797
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65596374
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64993418
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62111803
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62069600
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60700524
29POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60179796
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58875806
31XRN2_22483619_ChIP-Seq_HELA_Human1.58612705
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.56880078
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50409161
34ELK1_19687146_ChIP-ChIP_HELA_Human1.49616213
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.48655477
36TP53_22573176_ChIP-Seq_HFKS_Human1.45261135
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.40975961
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39762699
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.39663451
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38083800
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.36962259
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31291097
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30742974
44TAF2_19829295_ChIP-Seq_ESCs_Human1.30272115
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29975846
46GABP_19822575_ChIP-Seq_HepG2_Human1.29620810
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29482025
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26387308
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25600656
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24541829
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24064578
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24035140
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23922133
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22562421
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.21168572
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20568820
57REST_21632747_ChIP-Seq_MESCs_Mouse1.19356027
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.18548786
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.18380155
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17519348
61EWS_26573619_Chip-Seq_HEK293_Human1.17486359
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16139554
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15965674
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.15308482
65NCOR_22424771_ChIP-Seq_293T_Human1.14476150
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12553129
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.11011076
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08908747
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08588116
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07068128
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06798756
72P300_19829295_ChIP-Seq_ESCs_Human1.06338301
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.06299655
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.04107947
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03556648
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.03556648
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03450883
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03283139
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01414857
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00266478
81CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99727905
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99690851
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99511901
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.97784755
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96836790
86ERA_21632823_ChIP-Seq_H3396_Human0.96326739
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95325695
88DCP1A_22483619_ChIP-Seq_HELA_Human0.95034446
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92926430
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92809847
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92299551
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87594487
93NANOG_20526341_ChIP-Seq_ESCs_Human0.87221753
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87080984
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.86748921
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.86269181
97RNF2_27304074_Chip-Seq_NSC_Mouse0.85335374
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85209444
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84678000
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.83795826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.48413118
2MP0009379_abnormal_foot_pigmentation4.81975594
3MP0008789_abnormal_olfactory_epithelium3.27057342
4MP0002163_abnormal_gland_morphology3.26987099
5MP0003787_abnormal_imprinting3.07282606
6MP0003123_paternal_imprinting2.74967527
7MP0005499_abnormal_olfactory_system2.62857003
8MP0005394_taste/olfaction_phenotype2.62857003
9MP0003122_maternal_imprinting2.61908842
10MP0002102_abnormal_ear_morphology2.49140336
11MP0001529_abnormal_vocalization2.45108989
12MP0002837_dystrophic_cardiac_calcinosis2.36059086
13MP0003646_muscle_fatigue2.22917369
14MP0001968_abnormal_touch/_nociception2.17461062
15MP0000372_irregular_coat_pigmentation2.15175943
16MP0002736_abnormal_nociception_after2.11014999
17MP0010030_abnormal_orbit_morphology2.10188846
18MP0001293_anophthalmia2.09599336
19MP0004142_abnormal_muscle_tone2.08987562
20MP0008877_abnormal_DNA_methylation2.07088402
21MP0003121_genomic_imprinting2.05977038
22MP0005379_endocrine/exocrine_gland_phen2.01088017
23MP0005377_hearing/vestibular/ear_phenot1.96590555
24MP0003878_abnormal_ear_physiology1.96590555
25MP0002938_white_spotting1.77320061
26MP0001348_abnormal_lacrimal_gland1.65602342
27MP0002653_abnormal_ependyma_morphology1.60353387
28MP0004885_abnormal_endolymph1.55329247
29MP0000049_abnormal_middle_ear1.54010347
30MP0001485_abnormal_pinna_reflex1.48825130
31MP0008872_abnormal_physiological_respon1.47276240
32MP0008775_abnormal_heart_ventricle1.41290213
33MP0008875_abnormal_xenobiotic_pharmacok1.38745315
34MP0001984_abnormal_olfaction1.33837263
35MP0001440_abnormal_grooming_behavior1.31516490
36MP0002233_abnormal_nose_morphology1.30879535
37MP0005646_abnormal_pituitary_gland1.29169544
38MP0000778_abnormal_nervous_system1.25388527
39MP0002095_abnormal_skin_pigmentation1.22107226
40MP0000631_abnormal_neuroendocrine_gland1.20454127
41MP0002234_abnormal_pharynx_morphology1.20078007
42MP0006276_abnormal_autonomic_nervous1.19011104
43MP0001905_abnormal_dopamine_level1.17921910
44MP0001502_abnormal_circadian_rhythm1.16091365
45MP0005551_abnormal_eye_electrophysiolog1.15743797
46MP0003186_abnormal_redox_activity1.15340250
47MP0002272_abnormal_nervous_system1.13108270
48MP0005408_hypopigmentation1.12295616
49MP0003567_abnormal_fetal_cardiomyocyte1.11815748
50MP0009745_abnormal_behavioral_response1.10663485
51MP0000566_synostosis1.07608361
52MP0002210_abnormal_sex_determination1.05572313
53MP0009250_abnormal_appendicular_skeleto1.03421677
54MP0005195_abnormal_posterior_eye1.03337253
55MP0002733_abnormal_thermal_nociception1.00298446
56MP0003936_abnormal_reproductive_system0.98091262
57MP0000026_abnormal_inner_ear0.96214166
58MP0009053_abnormal_anal_canal0.94894559
59MP0005389_reproductive_system_phenotype0.94663617
60MP0001286_abnormal_eye_development0.93877852
61MP0002557_abnormal_social/conspecific_i0.92924381
62MP0001970_abnormal_pain_threshold0.92546560
63MP0003693_abnormal_embryo_hatching0.91601832
64MP0003011_delayed_dark_adaptation0.90405647
65MP0003937_abnormal_limbs/digits/tail_de0.87019754
66MP0004145_abnormal_muscle_electrophysio0.86119042
67MP0002752_abnormal_somatic_nervous0.83653016
68MP0002572_abnormal_emotion/affect_behav0.83329189
69MP0003137_abnormal_impulse_conducting0.83186958
70MP0002138_abnormal_hepatobiliary_system0.82529516
71MP0002184_abnormal_innervation0.80360602
72MP0001986_abnormal_taste_sensitivity0.79445843
73MP0002277_abnormal_respiratory_mucosa0.77814923
74MP0003938_abnormal_ear_development0.77447356
75MP0005174_abnormal_tail_pigmentation0.77381530
76MP0002160_abnormal_reproductive_system0.77110631
77MP0000653_abnormal_sex_gland0.76814666
78MP0002734_abnormal_mechanical_nocicepti0.76543504
79MP0001145_abnormal_male_reproductive0.75973507
80MP0006072_abnormal_retinal_apoptosis0.75154073
81MP0000955_abnormal_spinal_cord0.74905498
82MP0002063_abnormal_learning/memory/cond0.73252472
83MP0000647_abnormal_sebaceous_gland0.72326722
84MP0001663_abnormal_digestive_system0.71397369
85MP0001919_abnormal_reproductive_system0.71353055
86MP0001929_abnormal_gametogenesis0.70941805
87MP0002876_abnormal_thyroid_physiology0.70860641
88MP0002282_abnormal_trachea_morphology0.70766562
89MP0003755_abnormal_palate_morphology0.70252615
90MP0001501_abnormal_sleep_pattern0.70185187
91MP0000230_abnormal_systemic_arterial0.69485245
92MP0005084_abnormal_gallbladder_morpholo0.68417523
93MP0001764_abnormal_homeostasis0.68305628
94MP0005423_abnormal_somatic_nervous0.68303475
95MP0002067_abnormal_sensory_capabilities0.66858021
96MP0005253_abnormal_eye_physiology0.65622390
97MP0005391_vision/eye_phenotype0.65198511
98MP0003698_abnormal_male_reproductive0.63581968
99MP0004043_abnormal_pH_regulation0.62416044
100MP0001324_abnormal_eye_pigmentation0.62279703

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.62950078
2Acute necrotizing encephalopathy (HP:0006965)4.61876900
3Abnormality of cells of the erythroid lineage (HP:0012130)4.04932322
4Abnormal mitochondria in muscle tissue (HP:0008316)4.01386197
5Acute encephalopathy (HP:0006846)3.82937062
6Progressive macrocephaly (HP:0004481)3.73991839
7Pancreatic fibrosis (HP:0100732)3.65421132
8Mitochondrial inheritance (HP:0001427)3.56445277
9Macrocytic anemia (HP:0001972)3.55854724
10Increased CSF lactate (HP:0002490)3.24714241
11True hermaphroditism (HP:0010459)3.21414253
12Abnormality of midbrain morphology (HP:0002418)3.20749847
13Molar tooth sign on MRI (HP:0002419)3.20749847
14Pancreatic cysts (HP:0001737)3.20287720
15Adrenal hypoplasia (HP:0000835)3.14231168
16Colon cancer (HP:0003003)3.02408057
17Cerebral edema (HP:0002181)2.97850018
18Absent thumb (HP:0009777)2.95841495
19Pallor (HP:0000980)2.92237016
20Sclerocornea (HP:0000647)2.91525167
21Medial flaring of the eyebrow (HP:0010747)2.88914557
22Abnormality of DNA repair (HP:0003254)2.81105804
23Increased hepatocellular lipid droplets (HP:0006565)2.75975876
24Rib fusion (HP:0000902)2.75849133
25Abnormal number of erythroid precursors (HP:0012131)2.70960812
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63993184
27Septo-optic dysplasia (HP:0100842)2.63341391
28Nephronophthisis (HP:0000090)2.55873566
29Abnormal biliary tract physiology (HP:0012439)2.54581889
30Bile duct proliferation (HP:0001408)2.54581889
31Hepatocellular necrosis (HP:0001404)2.53130371
32Abnormality of the renal medulla (HP:0100957)2.52228330
3311 pairs of ribs (HP:0000878)2.49495723
34Pendular nystagmus (HP:0012043)2.48172045
35Lipid accumulation in hepatocytes (HP:0006561)2.47319578
36Gait imbalance (HP:0002141)2.42615268
37Chronic hepatic failure (HP:0100626)2.41183636
38Congenital primary aphakia (HP:0007707)2.40330346
39Methylmalonic acidemia (HP:0002912)2.39743168
40Abnormality of the renal cortex (HP:0011035)2.38465356
41Stenosis of the external auditory canal (HP:0000402)2.37115299
42Postaxial foot polydactyly (HP:0001830)2.35862617
43Anophthalmia (HP:0000528)2.35188942
44Asplenia (HP:0001746)2.34833191
45Metabolic alkalosis (HP:0200114)2.33512205
46Abnormality of alanine metabolism (HP:0010916)2.30843912
47Hyperalaninemia (HP:0003348)2.30843912
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30843912
49Optic disc pallor (HP:0000543)2.30505659
50Nephrogenic diabetes insipidus (HP:0009806)2.28917490
51Poor coordination (HP:0002370)2.27719340
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.24761699
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.24469601
54Depressed nasal ridge (HP:0000457)2.22704732
55Hepatic necrosis (HP:0002605)2.20738037
56Abnormality of the labia minora (HP:0012880)2.17206675
57Type II lissencephaly (HP:0007260)2.15629663
583-Methylglutaconic aciduria (HP:0003535)2.07832915
59Polyuria (HP:0000103)2.07307799
60Methylmalonic aciduria (HP:0012120)2.07289507
61Cystic liver disease (HP:0006706)2.06741016
62Renal Fanconi syndrome (HP:0001994)2.05879167
63Hypoplasia of the pons (HP:0012110)2.05236620
64Congenital, generalized hypertrichosis (HP:0004540)2.03922758
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01303451
66Enlarged kidneys (HP:0000105)2.00220466
67Exercise intolerance (HP:0003546)2.00192683
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98631509
69Horseshoe kidney (HP:0000085)1.96657777
70Leukodystrophy (HP:0002415)1.95916518
71Increased serum lactate (HP:0002151)1.95007875
72Abnormal ciliary motility (HP:0012262)1.92884696
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.92645359
74Abnormal rod and cone electroretinograms (HP:0008323)1.92641221
75Congenital hepatic fibrosis (HP:0002612)1.92504228
76Tubular atrophy (HP:0000092)1.91579947
77Hypoplasia of the ulna (HP:0003022)1.88249968
78Occipital encephalocele (HP:0002085)1.86692467
79Abnormality of magnesium homeostasis (HP:0004921)1.84984505
80Congenital stationary night blindness (HP:0007642)1.84954900
81Abnormality of the pons (HP:0007361)1.84529919
82Increased intramyocellular lipid droplets (HP:0012240)1.84168770
83Lactic acidosis (HP:0003128)1.83197631
84Anencephaly (HP:0002323)1.82909971
85Hypoplasia of the radius (HP:0002984)1.81997463
86Male pseudohermaphroditism (HP:0000037)1.79922756
87Postaxial hand polydactyly (HP:0001162)1.77285514
88Retinal dysplasia (HP:0007973)1.77053093
89Abnormality of renal resorption (HP:0011038)1.75196163
90Ectopic kidney (HP:0000086)1.74701364
91Symphalangism affecting the phalanges of the hand (HP:0009773)1.74538931
92Forearm undergrowth (HP:0009821)1.73317022
93Triphalangeal thumb (HP:0001199)1.73135198
94Missing ribs (HP:0000921)1.72538365
95Exertional dyspnea (HP:0002875)1.71880355
96Abnormality of the metopic suture (HP:0005556)1.71338923
97Type 2 muscle fiber atrophy (HP:0003554)1.70759352
98Rectovaginal fistula (HP:0000143)1.70393228
99Rectal fistula (HP:0100590)1.70393228
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69183875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.78625270
2WNK43.64926467
3TIE13.30365314
4BCKDK3.02596687
5ADRBK22.82789394
6PIK3CA2.75422772
7GRK12.19181256
8DYRK22.10024271
9WNK32.02140967
10MAP3K41.90056647
11ZAK1.88565312
12CDK191.85016937
13PLK41.74773986
14STK391.74155896
15LIMK11.73813237
16CDK81.70838867
17MAP3K111.64653389
18TAF11.54133642
19FRK1.52650930
20VRK21.47437450
21MAP2K71.41737836
22NEK21.40205391
23VRK11.37039588
24SRPK11.32839229
25EPHA41.32608173
26STK161.30422598
27TLK11.29075384
28LRRK21.26037145
29PRKCG1.23357966
30MAP3K121.19484834
31BMPR1B1.13218995
32NUAK11.13160833
33PLK31.11572838
34PINK11.09163018
35CAMK1D1.07588495
36BRAF1.05803013
37MAP3K91.05605630
38PASK1.04374446
39STK241.00244272
40MAP2K40.98523129
41WEE10.96720358
42OXSR10.96068751
43EPHB20.94779136
44TXK0.94195833
45DYRK30.92816666
46PLK10.91727270
47CAMK10.91144777
48AURKB0.89407468
49NTRK20.89232787
50CHEK20.88026095
51CAMKK20.86847081
52TRIM280.86315139
53NME10.81412003
54PDK20.80884186
55MKNK20.80437072
56MINK10.74087350
57CSNK2A20.72528615
58CDC70.70833137
59MAP2K60.70787498
60CAMKK10.69985606
61PRKCQ0.69188418
62IKBKB0.67311547
63ATR0.66908520
64CAMK1G0.66783429
65TGFBR10.65382291
66RPS6KA60.64703712
67INSRR0.61922898
68ADRBK10.61236435
69MAPK150.60746799
70PRKCH0.60549195
71GRK50.57785682
72PRKACA0.56291209
73CAMK2D0.54910236
74MARK20.54211920
75DYRK1A0.50896887
76BTK0.49717545
77PRKCE0.49548174
78DAPK30.49543504
79SGK4940.49487121
80SGK2230.49487121
81RPS6KL10.49011909
82RPS6KC10.49011909
83PHKG10.48518699
84PHKG20.48518699
85PRKCD0.47869342
86CSNK1A10.47022573
87CAMK40.46672893
88STK110.46316251
89CAMK2A0.44552611
90BRSK10.44398040
91PAK30.43844276
92TNK20.42486131
93PRKD30.41954145
94WNK10.41877995
95CSNK2A10.41383538
96PLK20.40914957
97PRKCA0.40881285
98STK30.40449764
99NTRK30.38215389
100MAPK130.37414419

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.60454673
2Oxidative phosphorylation_Homo sapiens_hsa001903.82496787
3Parkinsons disease_Homo sapiens_hsa050123.18295651
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58003598
5Sulfur relay system_Homo sapiens_hsa041222.43378322
6Huntingtons disease_Homo sapiens_hsa050162.35833789
7Alzheimers disease_Homo sapiens_hsa050102.18411778
8Proteasome_Homo sapiens_hsa030502.17997276
9Protein export_Homo sapiens_hsa030602.09980435
10Base excision repair_Homo sapiens_hsa034102.01220514
11Cardiac muscle contraction_Homo sapiens_hsa042602.00000662
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93750241
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89254881
14Nucleotide excision repair_Homo sapiens_hsa034201.88332908
15RNA degradation_Homo sapiens_hsa030181.84498831
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83674099
17Homologous recombination_Homo sapiens_hsa034401.79280687
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78135962
19Caffeine metabolism_Homo sapiens_hsa002321.72023340
20RNA polymerase_Homo sapiens_hsa030201.70666815
21Fanconi anemia pathway_Homo sapiens_hsa034601.68508846
22Mismatch repair_Homo sapiens_hsa034301.68463944
23Linoleic acid metabolism_Homo sapiens_hsa005911.67439460
24One carbon pool by folate_Homo sapiens_hsa006701.58431037
25Basal transcription factors_Homo sapiens_hsa030221.51529500
26Pyrimidine metabolism_Homo sapiens_hsa002401.50079493
27DNA replication_Homo sapiens_hsa030301.49975447
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43749445
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25962431
30Selenocompound metabolism_Homo sapiens_hsa004501.25384522
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21593144
32Propanoate metabolism_Homo sapiens_hsa006401.19391759
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16364036
34Spliceosome_Homo sapiens_hsa030401.14519826
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07448768
36Pyruvate metabolism_Homo sapiens_hsa006201.07209207
37Steroid biosynthesis_Homo sapiens_hsa001001.06105690
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04015113
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02089543
40Nitrogen metabolism_Homo sapiens_hsa009101.01556721
41Ether lipid metabolism_Homo sapiens_hsa005651.01075548
42Nicotine addiction_Homo sapiens_hsa050330.99935355
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94727335
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93399005
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92611486
46Phototransduction_Homo sapiens_hsa047440.89705750
47Purine metabolism_Homo sapiens_hsa002300.89430884
48Asthma_Homo sapiens_hsa053100.88634170
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88204186
50RNA transport_Homo sapiens_hsa030130.86421980
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82842146
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.81494028
53Tryptophan metabolism_Homo sapiens_hsa003800.79208252
54Fatty acid biosynthesis_Homo sapiens_hsa000610.78151859
55Peroxisome_Homo sapiens_hsa041460.77903947
56beta-Alanine metabolism_Homo sapiens_hsa004100.76317863
57Arachidonic acid metabolism_Homo sapiens_hsa005900.76045723
58Metabolic pathways_Homo sapiens_hsa011000.75782490
59Basal cell carcinoma_Homo sapiens_hsa052170.75702409
60Folate biosynthesis_Homo sapiens_hsa007900.74913996
61Regulation of autophagy_Homo sapiens_hsa041400.74006632
62Arginine and proline metabolism_Homo sapiens_hsa003300.68647428
63Hedgehog signaling pathway_Homo sapiens_hsa043400.68646821
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68510395
65Collecting duct acid secretion_Homo sapiens_hsa049660.66031373
66Fat digestion and absorption_Homo sapiens_hsa049750.65203085
67Glycerolipid metabolism_Homo sapiens_hsa005610.59674069
68Sulfur metabolism_Homo sapiens_hsa009200.56080302
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.53367652
70Butanoate metabolism_Homo sapiens_hsa006500.50774329
71Notch signaling pathway_Homo sapiens_hsa043300.49091643
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.47701728
73Fatty acid degradation_Homo sapiens_hsa000710.43338289
74Olfactory transduction_Homo sapiens_hsa047400.43172070
75Ovarian steroidogenesis_Homo sapiens_hsa049130.39770843
76mRNA surveillance pathway_Homo sapiens_hsa030150.39475613
77Hippo signaling pathway_Homo sapiens_hsa043900.38700181
78Chemical carcinogenesis_Homo sapiens_hsa052040.38179893
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.35909945
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33244270
81Tyrosine metabolism_Homo sapiens_hsa003500.31740485
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30757055
83Glutathione metabolism_Homo sapiens_hsa004800.30640585
84Wnt signaling pathway_Homo sapiens_hsa043100.28955410
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28713091
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26421152
87Vitamin digestion and absorption_Homo sapiens_hsa049770.25395764
88Retinol metabolism_Homo sapiens_hsa008300.25276776
89Morphine addiction_Homo sapiens_hsa050320.25127476
90Histidine metabolism_Homo sapiens_hsa003400.24108281
91p53 signaling pathway_Homo sapiens_hsa041150.24052683
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24021223
93Fatty acid elongation_Homo sapiens_hsa000620.23582605
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22358658
95Insulin secretion_Homo sapiens_hsa049110.20728397
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20352221
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19862391
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18886669
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18726645
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18217254

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