RPSAP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of penile erection (GO:0060405)9.65587231
2short-term memory (GO:0007614)9.61023947
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.41652629
4specification of organ identity (GO:0010092)8.36376184
5regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)8.20556037
6regulation of dopamine uptake involved in synaptic transmission (GO:0051584)8.20556037
7behavioral response to ethanol (GO:0048149)7.93145385
8regulation of inhibitory postsynaptic membrane potential (GO:0060080)7.90205472
9oxygen transport (GO:0015671)7.83214896
10prenylation (GO:0097354)7.80912501
11protein prenylation (GO:0018342)7.80912501
12adaptation of signaling pathway (GO:0023058)7.27066268
13hindbrain development (GO:0030902)7.25337723
14response to histamine (GO:0034776)6.84559862
15positive regulation of sodium ion transmembrane transporter activity (GO:2000651)6.69556098
16chemosensory behavior (GO:0007635)6.57862083
17mitochondrion localization (GO:0051646)6.38846387
18gas transport (GO:0015669)6.11851456
19behavioral response to cocaine (GO:0048148)6.10468217
20regulation of neurotransmitter uptake (GO:0051580)6.07590111
21synaptic transmission, dopaminergic (GO:0001963)5.91068275
22arachidonic acid secretion (GO:0050482)5.87927534
23icosanoid secretion (GO:0032309)5.87927534
24regulation of voltage-gated calcium channel activity (GO:1901385)5.57130100
25positive regulation of sodium ion transmembrane transport (GO:1902307)5.28061546
26cellular response to zinc ion (GO:0071294)4.99680073
27regulation of proton transport (GO:0010155)4.98403609
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.96461572
29mitochondrion transport along microtubule (GO:0047497)4.96461572
30positive regulation of cell size (GO:0045793)4.89368840
31regulation of catecholamine metabolic process (GO:0042069)4.88958634
32regulation of dopamine metabolic process (GO:0042053)4.88958634
33positive regulation of RNA splicing (GO:0033120)4.76514988
34icosanoid transport (GO:0071715)4.65465206
35fatty acid derivative transport (GO:1901571)4.65465206
36RNA destabilization (GO:0050779)4.57940552
37establishment of mitochondrion localization (GO:0051654)4.52153940
38positive regulation of mRNA processing (GO:0050685)4.51119721
39retina development in camera-type eye (GO:0060041)4.35386666
40negative regulation of cation channel activity (GO:2001258)4.35103324
41negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.31250283
42negative regulation of calcium ion transmembrane transport (GO:1903170)4.31250283
43regulation of synaptic transmission, dopaminergic (GO:0032225)4.30935380
44cellular response to cadmium ion (GO:0071276)4.22752743
45positive regulation of neurotransmitter transport (GO:0051590)4.04993937
46positive regulation of amine transport (GO:0051954)3.99551148
47cell fate commitment involved in formation of primary germ layer (GO:0060795)3.96109135
48multicellular organism reproduction (GO:0032504)3.94100355
49base-excision repair, AP site formation (GO:0006285)3.94082163
50bicarbonate transport (GO:0015701)3.89321240
51pyrimidine nucleobase catabolic process (GO:0006208)3.84653812
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83493054
53positive regulation of protein deacetylation (GO:0090312)3.71427489
54positive regulation of microtubule polymerization (GO:0031116)3.67762725
55membrane hyperpolarization (GO:0060081)3.66635050
56regulation of systemic arterial blood pressure (GO:0003073)3.66273278
57positive regulation of mRNA metabolic process (GO:1903313)3.63631804
58regulation of rhodopsin mediated signaling pathway (GO:0022400)3.61776296
59negative regulation of adenylate cyclase activity (GO:0007194)3.58525306
60negative regulation of cAMP biosynthetic process (GO:0030818)3.55479022
61dopamine receptor signaling pathway (GO:0007212)3.52853686
62positive regulation of signal transduction by p53 class mediator (GO:1901798)3.51549493
63behavioral fear response (GO:0001662)3.50916856
64behavioral defense response (GO:0002209)3.50916856
65positive regulation of oligodendrocyte differentiation (GO:0048714)3.50319492
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47774927
67regulation of monocyte differentiation (GO:0045655)3.47272584
68negative regulation of JUN kinase activity (GO:0043508)3.43337481
69negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.42239888
70negative regulation of cyclase activity (GO:0031280)3.40746199
71response to amphetamine (GO:0001975)3.36474035
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.36182487
73NADH dehydrogenase complex assembly (GO:0010257)3.36182487
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36182487
75negative regulation of lyase activity (GO:0051350)3.33348870
76negative regulation of cAMP metabolic process (GO:0030815)3.28283872
77nucleobase catabolic process (GO:0046113)3.27444992
78regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.25808326
79pyrimidine nucleotide catabolic process (GO:0006244)3.25249303
80rhodopsin mediated signaling pathway (GO:0016056)3.24460408
81negative regulation of nucleotide biosynthetic process (GO:0030809)3.19262542
82negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.19262542
83response to misfolded protein (GO:0051788)3.19191549
84negative regulation of response to food (GO:0032096)3.17602051
85negative regulation of appetite (GO:0032099)3.17602051
86negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.16956525
87regulation of protein deacetylation (GO:0090311)3.13430549
88misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.12682890
89translesion synthesis (GO:0019985)3.10273605
90histone H3-K4 trimethylation (GO:0080182)3.05769398
91positive regulation of histone H3-K4 methylation (GO:0051571)3.02668463
92negative regulation of digestive system process (GO:0060457)2.98813913
93protein K11-linked deubiquitination (GO:0035871)2.97163399
94fear response (GO:0042596)2.94583358
95protein targeting to Golgi (GO:0000042)2.93951381
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91892286
97regulation of calcium-mediated signaling (GO:0050848)2.91281854
98erythrocyte maturation (GO:0043249)2.90569889
99sperm capacitation (GO:0048240)2.90406558
100mitochondrion distribution (GO:0048311)10.1314780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.42468135
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.27930481
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44387120
4ZNF274_21170338_ChIP-Seq_K562_Hela2.38255528
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36496217
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25577039
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17838619
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.16056129
9IGF1R_20145208_ChIP-Seq_DFB_Human2.08380895
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04691261
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse11.9001791
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99025750
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97561981
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.96257944
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87691502
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.84863460
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.84858911
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81883024
19REST_21632747_ChIP-Seq_MESCs_Mouse1.81234377
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.73319004
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71255770
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67205302
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.65581370
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.64109641
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63557655
26IRF1_19129219_ChIP-ChIP_H3396_Human1.61527968
27DROSHA_22980978_ChIP-Seq_HELA_Human1.60267536
28KLF5_20875108_ChIP-Seq_MESCs_Mouse1.59113523
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.55532251
30P300_19829295_ChIP-Seq_ESCs_Human1.52143188
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51034020
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50127082
33GBX2_23144817_ChIP-Seq_PC3_Human1.49365516
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41813362
35RUNX2_22187159_ChIP-Seq_PCA_Human1.39850800
36ELK1_19687146_ChIP-ChIP_HELA_Human1.39429488
37ERA_21632823_ChIP-Seq_H3396_Human1.38649247
38P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36204582
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.33019713
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32778902
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.31837309
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31707592
43TAF15_26573619_Chip-Seq_HEK293_Human1.30998643
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.29011239
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28514758
46BCAT_22108803_ChIP-Seq_LS180_Human1.24610102
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23358787
48RNF2_27304074_Chip-Seq_NSC_Mouse1.20691115
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20379915
50VDR_22108803_ChIP-Seq_LS180_Human1.18936869
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18134811
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17566313
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16382552
54ER_23166858_ChIP-Seq_MCF-7_Human1.16251443
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14667926
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13523206
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12947055
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11658367
59RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11134838
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10692883
61EZH2_22144423_ChIP-Seq_EOC_Human1.10136398
62JUN_21703547_ChIP-Seq_K562_Human1.09798397
63STAT1_17558387_ChIP-Seq_HELA_Human1.09630601
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08892029
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08859789
66AR_25329375_ChIP-Seq_VCAP_Human1.07107175
67MYC_19829295_ChIP-Seq_ESCs_Human1.02865918
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01989982
69OCT4_20526341_ChIP-Seq_ESCs_Human1.00637904
70ETV1_20927104_ChIP-Seq_GIST48_Human1.00017558
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98253938
72EWS_26573619_Chip-Seq_HEK293_Human0.97915683
73TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97048087
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97005547
75BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.96463606
76NCOR_22424771_ChIP-Seq_293T_Human0.96444472
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95902655
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93527840
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92868516
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91726040
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.91490130
82E2F1_18555785_Chip-Seq_ESCs_Mouse0.91087835
83SMAD4_21799915_ChIP-Seq_A2780_Human0.89400275
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88615315
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.86865796
86EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86685769
87RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86685769
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85965389
89STAT3_23295773_ChIP-Seq_U87_Human0.85365125
90TBL1_22424771_ChIP-Seq_293T_Human0.85326447
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84954472
92TCF4_22108803_ChIP-Seq_LS180_Human0.84650247
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82327718
94RBPJ_21746931_ChIP-Seq_IB4_Human0.81450925
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79414801
96AR_21572438_ChIP-Seq_LNCaP_Human0.78161044
97TP53_22573176_ChIP-Seq_HFKS_Human0.77537296
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.76844254
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.76786232
100AR_20517297_ChIP-Seq_VCAP_Human0.76241693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001293_anophthalmia3.92408531
2MP0004859_abnormal_synaptic_plasticity3.62407962
3MP0001348_abnormal_lacrimal_gland3.45632456
4MP0002638_abnormal_pupillary_reflex3.40338413
5MP0003878_abnormal_ear_physiology3.27201536
6MP0005377_hearing/vestibular/ear_phenot3.27201536
7MP0000462_abnormal_digestive_system3.21557440
8MP0001905_abnormal_dopamine_level3.05613358
9MP0005423_abnormal_somatic_nervous2.97661191
10MP0001529_abnormal_vocalization2.47673983
11MP0005551_abnormal_eye_electrophysiolog2.36908351
12MP0002572_abnormal_emotion/affect_behav2.34110398
13MP0002277_abnormal_respiratory_mucosa2.33274199
14MP0001485_abnormal_pinna_reflex2.27547451
15MP0002233_abnormal_nose_morphology2.24595407
16MP0004133_heterotaxia2.20155327
17MP0001984_abnormal_olfaction2.19180114
18MP0003567_abnormal_fetal_cardiomyocyte2.04471271
19MP0000566_synostosis2.02108439
20MP0002272_abnormal_nervous_system1.85674988
21MP0008877_abnormal_DNA_methylation1.73016430
22MP0002735_abnormal_chemical_nociception1.68927043
23MP0002733_abnormal_thermal_nociception1.67865642
24MP0008775_abnormal_heart_ventricle1.66542812
25MP0009745_abnormal_behavioral_response1.65179916
26MP0003252_abnormal_bile_duct1.64839966
27MP0001440_abnormal_grooming_behavior1.64799734
28MP0008875_abnormal_xenobiotic_pharmacok1.61317163
29MP0005645_abnormal_hypothalamus_physiol1.56570335
30MP0004885_abnormal_endolymph1.55977172
31MP0008995_early_reproductive_senescence1.50557216
32MP0008872_abnormal_physiological_respon1.49077720
33MP0005084_abnormal_gallbladder_morpholo1.41897822
34MP0002063_abnormal_learning/memory/cond1.41038234
35MP0009046_muscle_twitch1.38498015
36MP0003635_abnormal_synaptic_transmissio1.36642808
37MP0002092_abnormal_eye_morphology1.36007822
38MP0002102_abnormal_ear_morphology1.31705736
39MP0003195_calcinosis1.28796698
40MP0002928_abnormal_bile_duct1.28210896
41MP0001970_abnormal_pain_threshold1.26819950
42MP0008789_abnormal_olfactory_epithelium1.22644920
43MP0005391_vision/eye_phenotype1.20319750
44MP0001324_abnormal_eye_pigmentation1.19417209
45MP0003943_abnormal_hepatobiliary_system1.17007731
46MP0005671_abnormal_response_to1.15693755
47MP0000955_abnormal_spinal_cord1.14769368
48MP0001486_abnormal_startle_reflex1.14311329
49MP0009840_abnormal_foam_cell1.14149816
50MP0000778_abnormal_nervous_system1.12902387
51MP0003806_abnormal_nucleotide_metabolis1.11207524
52MP0005195_abnormal_posterior_eye1.10397364
53MP0005381_digestive/alimentary_phenotyp1.09766546
54MP0003329_amyloid_beta_deposits1.08016369
55MP0010030_abnormal_orbit_morphology1.06627782
56MP0006276_abnormal_autonomic_nervous1.06558601
57MP0002752_abnormal_somatic_nervous1.06250367
58MP0001879_abnormal_lymphatic_vessel1.06156869
59MP0002069_abnormal_eating/drinking_beha1.04325963
60MP0001299_abnormal_eye_distance/1.02352056
61MP0002067_abnormal_sensory_capabilities1.00792429
62MP0004145_abnormal_muscle_electrophysio0.98811258
63MP0004742_abnormal_vestibular_system0.98092044
64MP0009333_abnormal_splenocyte_physiolog0.94937135
65MP0002557_abnormal_social/conspecific_i0.94487039
66MP0002152_abnormal_brain_morphology0.92912610
67MP0004147_increased_porphyrin_level0.92408853
68MP0002229_neurodegeneration0.92126065
69MP0002882_abnormal_neuron_morphology0.91712124
70MP0000049_abnormal_middle_ear0.91103278
71MP0002064_seizures0.90932140
72MP0002822_catalepsy0.90082963
73MP0004142_abnormal_muscle_tone0.87831547
74MP0005253_abnormal_eye_physiology0.87021978
75MP0002734_abnormal_mechanical_nocicepti0.86662287
76MP0000750_abnormal_muscle_regeneration0.85075186
77MP0000569_abnormal_digit_pigmentation0.84989348
78MP0000427_abnormal_hair_cycle0.84234868
79MP0003283_abnormal_digestive_organ0.84160610
80MP0001963_abnormal_hearing_physiology0.83847400
81MP0000026_abnormal_inner_ear0.82912726
82MP0003879_abnormal_hair_cell0.81981319
83MP0001502_abnormal_circadian_rhythm0.81392176
84MP0002932_abnormal_joint_morphology0.78573733
85MP0000372_irregular_coat_pigmentation0.77128167
86MP0002332_abnormal_exercise_endurance0.76712919
87MP0003755_abnormal_palate_morphology0.74992693
88MP0009764_decreased_sensitivity_to0.74542118
89MP0003186_abnormal_redox_activity0.73323491
90MP0009765_abnormal_xenobiotic_induced0.73145832
91MP0006072_abnormal_retinal_apoptosis0.70955059
92MP0003123_paternal_imprinting0.69510483
93MP0000579_abnormal_nail_morphology0.66224281
94MP0003698_abnormal_male_reproductive0.65541349
95MP0004782_abnormal_surfactant_physiolog0.63355303
96MP0005394_taste/olfaction_phenotype0.62884966
97MP0005499_abnormal_olfactory_system0.62884966
98MP0003121_genomic_imprinting0.62444332
99MP0004043_abnormal_pH_regulation0.60971282
100MP0008569_lethality_at_weaning0.60572623

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)9.04450424
2Congenital stationary night blindness (HP:0007642)5.62648857
3Tongue fasciculations (HP:0001308)5.52091654
4Fetal akinesia sequence (HP:0001989)5.04087195
5Large earlobe (HP:0009748)5.02004256
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88008654
7Muscle fibrillation (HP:0010546)4.86149481
8Retinal atrophy (HP:0001105)4.75148046
9Chromsome breakage (HP:0040012)4.21095288
10Submucous cleft hard palate (HP:0000176)4.11545490
11Shawl scrotum (HP:0000049)4.10650944
12Esotropia (HP:0000565)4.05248410
13Myokymia (HP:0002411)3.63331265
14Meningioma (HP:0002858)3.61272773
15Reticulocytopenia (HP:0001896)3.55488679
16Rib fusion (HP:0000902)3.52680844
17Severe muscular hypotonia (HP:0006829)3.43678623
18Megalencephaly (HP:0001355)3.35990764
19Abnormal rod and cone electroretinograms (HP:0008323)3.25001084
20Tented upper lip vermilion (HP:0010804)3.19107928
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.16484258
22Poor eye contact (HP:0000817)2.82843990
23Limb dystonia (HP:0002451)2.73579761
24Abnormal number of incisors (HP:0011064)2.69122569
25Partial agenesis of the corpus callosum (HP:0001338)2.67793096
26Molar tooth sign on MRI (HP:0002419)2.62417656
27Abnormality of midbrain morphology (HP:0002418)2.62417656
28Mutism (HP:0002300)2.60973967
29Gait imbalance (HP:0002141)2.59904932
30Duplicated collecting system (HP:0000081)2.58253011
31Abnormality of the renal collecting system (HP:0004742)2.52847439
32Round face (HP:0000311)2.52701819
33Renal tubular acidosis (HP:0001947)2.51513125
34Stomach cancer (HP:0012126)2.49622676
35Pachygyria (HP:0001302)2.49370909
36Abnormality of DNA repair (HP:0003254)2.49365265
37Action tremor (HP:0002345)2.48212169
38Truncal obesity (HP:0001956)2.46046393
39Failure to thrive in infancy (HP:0001531)2.41875870
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36883600
41Lissencephaly (HP:0001339)2.33370947
42EEG with generalized epileptiform discharges (HP:0011198)2.33304307
43Stillbirth (HP:0003826)2.30491500
44Hypercortisolism (HP:0001578)2.26639855
45Chronic hepatic failure (HP:0100626)2.24996473
46Hypsarrhythmia (HP:0002521)2.23909901
47Epileptiform EEG discharges (HP:0011182)2.23609286
48Exertional dyspnea (HP:0002875)2.23529642
49Abnormality of the septum pellucidum (HP:0007375)2.23130822
50Increased CSF lactate (HP:0002490)2.23038052
51Polyphagia (HP:0002591)2.21348092
52Progressive visual loss (HP:0000529)2.20435788
53Self-mutilation (HP:0000742)2.17942086
54Abnormal social behavior (HP:0012433)2.15366358
55Impaired social interactions (HP:0000735)2.15366358
56Nephroblastoma (Wilms tumor) (HP:0002667)2.12231342
57Medial flaring of the eyebrow (HP:0010747)2.11048297
58Embryonal renal neoplasm (HP:0011794)2.03884476
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.03146051
60Myotonia (HP:0002486)2.02998956
61Abnormality of pyrimidine metabolism (HP:0004353)2.00845805
62Supernumerary bones of the axial skeleton (HP:0009144)1.98650780
63Nephrogenic diabetes insipidus (HP:0009806)1.97875740
64Hypoplasia of the brainstem (HP:0002365)1.97839520
65Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97839520
66Sleep apnea (HP:0010535)1.95987326
67Retinal dysplasia (HP:0007973)1.94800677
68Apathy (HP:0000741)1.92214764
69Drooling (HP:0002307)1.92036627
70Progressive macrocephaly (HP:0004481)1.91592493
71Increased serum lactate (HP:0002151)1.90257246
72Ectopic kidney (HP:0000086)1.88590885
73Bifid tongue (HP:0010297)1.88157276
74Pancreatic fibrosis (HP:0100732)1.86945571
75Renal dysplasia (HP:0000110)1.86684495
76Optic nerve coloboma (HP:0000588)1.84931777
77Toxemia of pregnancy (HP:0100603)1.84771150
78CNS hypomyelination (HP:0003429)1.83563459
79Anencephaly (HP:0002323)1.81910346
80Thoracic kyphosis (HP:0002942)1.81591076
81Biliary tract neoplasm (HP:0100574)1.80766248
82Pancreatic cysts (HP:0001737)1.79033302
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.78879025
84Meckel diverticulum (HP:0002245)1.76412974
85Polymicrogyria (HP:0002126)1.75613217
86Abnormality of the ileum (HP:0001549)1.75496352
87Nephronophthisis (HP:0000090)1.75318369
88Excessive salivation (HP:0003781)1.74963483
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74319161
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74319161
91Supernumerary ribs (HP:0005815)1.73724088
92Renal tubular dysfunction (HP:0000124)1.73601619
93Hypochromic microcytic anemia (HP:0004840)1.73242122
94Diplopia (HP:0000651)1.73067347
95Abnormality of binocular vision (HP:0011514)1.73067347
96Diminished motivation (HP:0000745)1.73065063
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.68662780
98Absent/shortened dynein arms (HP:0200106)1.68662780
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68260066
100Hamartoma of the eye (HP:0010568)1.67911187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK28.01454407
2CDK194.28942909
3OXSR12.47577560
4MARK12.08451568
5PRPF4B10.9237904
6PHKG11.84926555
7PHKG21.84926555
8EEF2K1.82980706
9GRK11.76559009
10MAPKAPK31.75986865
11BMPR1B1.66383908
12DYRK21.57196395
13ADRBK21.44078158
14MAPK131.42887502
15CASK1.37227608
16ABL21.27826926
17CDK81.25883260
18FRK1.15111090
19PKN11.04464697
20MAP3K41.03882255
21IRAK30.98059956
22TYRO30.97872520
23ZAK0.91965102
24RPS6KA50.86874713
25MAPK120.86628522
26PRKAA10.80388388
27ILK0.77312323
28TRPM70.76666870
29PRKD30.75714856
30PRKCG0.72667220
31CAMK1D0.69749578
32FES0.69666774
33WNK30.64460246
34MAPKAPK50.63318132
35NTRK30.62096375
36SGK4940.60685282
37SGK2230.60685282
38RPS6KB20.60183906
39STK38L0.59713540
40TIE10.58572716
41TGFBR10.56236773
42STK110.55534936
43MKNK20.54724020
44MAP3K120.53224492
45PBK0.51157968
46MAP2K60.49603769
47EPHA30.48117539
48DAPK20.47449525
49PNCK0.45068702
50PRKCI0.45008099
51STK240.44744496
52MINK10.43779881
53CHEK20.43250786
54TRIM280.38800063
55CSNK1E0.38064487
56MAP3K70.35311798
57PINK10.34807387
58CAMK1G0.34660207
59RPS6KA20.33420726
60ABL10.32765148
61MAP2K40.32551841
62MAP2K30.32143259
63TSSK60.31571422
64IKBKB0.29972145
65SGK10.29596280
66VRK20.29386954
67PRKG10.27170960
68TAOK10.26535167
69CDK30.25938355
70EIF2AK20.25915902
71DAPK10.25534626
72PRKAA20.24042241
73PLK10.23958688
74DYRK1A0.22836984
75CSNK1A10.22735337
76PRKCD0.22164140
77WEE10.21081720
78RPS6KA10.20972569
79IRAK10.20588297
80PAK30.19196197
81CSNK2A20.17727323
82PRKACB0.17147733
83MKNK10.16238571
84MAPK90.16206410
85EIF2AK10.15500617
86MYLK0.15423151
87CDC70.15061422
88STK390.14786385
89MARK20.13841141
90CLK10.13689829
91PRKCE0.13329344
92ITK0.13111436
93ATM0.12890918
94CSNK1G10.12315480
95LIMK10.12261428
96PRKDC0.11688391
97CHEK10.11685452
98ADRBK10.10849160
99CDK90.10169182
100VRK10.09833264

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.82130698
2Phototransduction_Homo sapiens_hsa047443.36114612
3Bile secretion_Homo sapiens_hsa049762.95834062
4ErbB signaling pathway_Homo sapiens_hsa040122.29661673
5Oxidative phosphorylation_Homo sapiens_hsa001902.21598313
6Mineral absorption_Homo sapiens_hsa049782.19600886
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15384865
8Fatty acid biosynthesis_Homo sapiens_hsa000612.13313946
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09533303
10Dorso-ventral axis formation_Homo sapiens_hsa043202.08954549
11Prion diseases_Homo sapiens_hsa050202.01308550
12Nicotine addiction_Homo sapiens_hsa050331.95759759
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85840272
14Asthma_Homo sapiens_hsa053101.82015590
15Collecting duct acid secretion_Homo sapiens_hsa049661.77859640
16Parkinsons disease_Homo sapiens_hsa050121.71508901
17Protein export_Homo sapiens_hsa030601.64557341
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61546025
19Endometrial cancer_Homo sapiens_hsa052131.52739686
20Chemical carcinogenesis_Homo sapiens_hsa052041.49368249
21Other glycan degradation_Homo sapiens_hsa005111.47226194
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42334764
23Steroid biosynthesis_Homo sapiens_hsa001001.41327298
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41172846
25Dopaminergic synapse_Homo sapiens_hsa047281.41104346
26Base excision repair_Homo sapiens_hsa034101.40739239
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33242389
28Linoleic acid metabolism_Homo sapiens_hsa005911.29351159
29Peroxisome_Homo sapiens_hsa041461.25486422
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25225544
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.22774716
32Renal cell carcinoma_Homo sapiens_hsa052111.22399668
33Ovarian steroidogenesis_Homo sapiens_hsa049131.20324447
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14559766
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04989189
36Taste transduction_Homo sapiens_hsa047421.03084476
37Cardiac muscle contraction_Homo sapiens_hsa042601.02985975
38Allograft rejection_Homo sapiens_hsa053301.02118991
39Regulation of autophagy_Homo sapiens_hsa041401.00408996
40Ribosome_Homo sapiens_hsa030100.98418790
41Nitrogen metabolism_Homo sapiens_hsa009100.98290171
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98245776
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.92848986
44Leishmaniasis_Homo sapiens_hsa051400.92117604
45Homologous recombination_Homo sapiens_hsa034400.89061493
46Fatty acid metabolism_Homo sapiens_hsa012120.87769306
47Butanoate metabolism_Homo sapiens_hsa006500.85423070
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85366007
49Fatty acid degradation_Homo sapiens_hsa000710.85220434
50Autoimmune thyroid disease_Homo sapiens_hsa053200.84855507
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83525175
52Olfactory transduction_Homo sapiens_hsa047400.83218662
53Caffeine metabolism_Homo sapiens_hsa002320.83130790
54Morphine addiction_Homo sapiens_hsa050320.82426528
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81495314
56p53 signaling pathway_Homo sapiens_hsa041150.80248507
57Tryptophan metabolism_Homo sapiens_hsa003800.78506675
58Oxytocin signaling pathway_Homo sapiens_hsa049210.78151157
59RNA degradation_Homo sapiens_hsa030180.75909126
60Melanoma_Homo sapiens_hsa052180.74741600
61GABAergic synapse_Homo sapiens_hsa047270.74212316
62Alzheimers disease_Homo sapiens_hsa050100.71370080
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.65673004
64Retinol metabolism_Homo sapiens_hsa008300.60533196
65Ether lipid metabolism_Homo sapiens_hsa005650.59718243
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58830669
67Ras signaling pathway_Homo sapiens_hsa040140.56443921
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55728733
69Colorectal cancer_Homo sapiens_hsa052100.55396628
70Malaria_Homo sapiens_hsa051440.54730343
71Cholinergic synapse_Homo sapiens_hsa047250.54295174
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50738606
73Glutamatergic synapse_Homo sapiens_hsa047240.50637136
74mTOR signaling pathway_Homo sapiens_hsa041500.50306517
75Glycerolipid metabolism_Homo sapiens_hsa005610.46565767
76Sulfur relay system_Homo sapiens_hsa041220.45974042
77T cell receptor signaling pathway_Homo sapiens_hsa046600.45372084
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.45242272
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.43668547
80Serotonergic synapse_Homo sapiens_hsa047260.42902668
81Axon guidance_Homo sapiens_hsa043600.42897643
82Platelet activation_Homo sapiens_hsa046110.42211115
83Huntingtons disease_Homo sapiens_hsa050160.40957727
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.40330118
85Type I diabetes mellitus_Homo sapiens_hsa049400.40159439
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40125195
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39427505
88Fanconi anemia pathway_Homo sapiens_hsa034600.38922884
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38127589
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37033390
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36507998
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36392400
93Inositol phosphate metabolism_Homo sapiens_hsa005620.35006422
94MAPK signaling pathway_Homo sapiens_hsa040100.34858539
95Glutathione metabolism_Homo sapiens_hsa004800.34640845
96Fat digestion and absorption_Homo sapiens_hsa049750.34241842
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33594704
98cAMP signaling pathway_Homo sapiens_hsa040240.31641255
99Insulin secretion_Homo sapiens_hsa049110.31283011
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31036922

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